Suomen Solubiologit ry

Yhdistys edistää solubiologian tutkimusta, koulutusta, tiedotusta ja työpaikkojen perustamista solubiologeille harjoittaen koulutus- ja tiedotustoimintaa.

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Ajankohtaista

Post-Doctoral Positions in Drug Abuse/Pain Research at the University of Michigan

14.6.2019 | Avoimet työpaikat

We are currently seeking Post-Doctoral Fellows with experience in preclinical and cellular models of drug abuse and/or pain. Ongoing projects are related to the understanding of substance abuse, the development of medications the management of opiate and/or cocaine abuse and pain. The selected candidates may be eligible to join  our NIH  training grant on the Biology of Drug Abuse (seehttps://sites.google.com/umich.edu/bda/home).

Candidates should have strong communication skills and technical expertise, with a focus on either in vitro (e.g., cell signaling, immunohistochemistry, electrophysiology) or in vivo (e.g., self-administration or pain models, circuitry analysis) methods. An ability to integrate in vivo and in vitro findings will be an advantage. Applicants should have completed (or be about to complete) an MD or Ph.D. or equivalent degree in a relevant discipline (e.g., biochemistry, pharmacology, neuroscience, biological psychology, physiology etc.) and must be US citizens or permanent residents of the USA.

Positions are available starting late summer/early fall. For more information contact John Traynor (jtraynor@umich.edu) or Emily Jutkiewicz (ejutkiew@umich.edu) or speak to Emily or John at the INRC meeting.

To apply, e-mail an up-to-date CV with the names of 3 referees to jtraynor@umich.edu.

2 postdoctoral positions and 2 graduate student positions at the University of Oulu

14.6.2019 | Avoimet työpaikat

Two postdoctoral positions (application and more information in the link):

https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=1&id=00007562&lang=en

Two open postdoctoral researcher positions are available in the field of molecular cancer cell biology, systems genetics and functional genomics in the research groups led by Drs Aki Manninen (www.oulu.fi/biocenter/groups/manninen) and Gonghong Wei (www.oulu.fi/biocenter/groups/wei) at the Faculty of Biochemistry and Molecular Medicine (FBMM), Biocenter Oulu, University of Oulu, Oulu, Finland. We are looking for ambitious, highly motivated candidates who have enthusiasm and ability to work hard both independently and as a team member to tackle challenging problems to achieve common goals. The positions are funded for 3 years.

This project aims at characterizing integrin-associated molecular machineries driving cancer-promoting effects in prostate cancer cells focusing on the crosstalk between hemidesmosomes and focal adhesions. Transcriptional regulatory mechanisms of integrins, as well as crosstalk between integrin signaling, androgen receptor pathway and other relevant prostate cancer associated pathways will be investigated. Genomic analysis will focus on systems identification of causal genetic variants, causative genes and relevant pathways as well as their functional and biological effects on prostate cancer susceptibility, initiation and progression.

The project utilizes 3D cell culture models where, in addition to established prostate cancer cell lines, we develop novel study systems based on prostate cancer patient-derived prostate organoids. The candidates will also employ advanced microscopy techniques, virus-based genomic engineering, CRISPR-Cas9-mediated genome editing and state-of-art cancer genetics and functional genomics approaches. Further reading: Myllymäki et al., (2019), MCP, doi: 10.1074/mcp.RA118.001095.; Gao et al., (2018), Cell, 174:576-589.; Huang et al., (2014), Nat Genet. 46:126-135.; Zhang, K. et al. (2017) Oncogene, doi: 10.1038/onc.2017.177. 

Two PhD-student positions (application and more information in the link):

https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=1&id=00007583&lang=en

Applications are invited for two full-time doctoral student positions for a maximum of four years, starting at the earliest on 01.01.2020 in a Biocenter Oulu research project headed by Professors Gonghong Wei and Aki Manninen in the cancer genomics research unit, Faculty of Biochemistry and Molecular Medicine.

Our work aims to discover the roles of novel transcription factors and epigenetic regulators in cancer predisposition and progression, and to explore how these proteins misregulate genome-wide gene expression in particular during prostate cancer development. We also focus on the identification of causal genetic variants, genes and relevant pathways as well as their functional and biological effects on prostate cancer susceptibility, initiation and progression.

The positions will be supervised by Professors Gonghong Wei and Aki Manninen and are focused on mapping genome-wide binding sites (cistrome) for novel transcriptional regulators in prostate cancer cells and tissues. We will further investigate the cistrome-enriched prostate cancer risk-associated variants and thus integrate the eQTL, epigenome and three-dimensional (3D) genome data to unravel the biological roles of causal variants and genes. Functional validation of selected genetic variants, target genes and other relevant risk factors will be performed using genetically engineered prostate cancer models. The projects utilize 3D cell culture models, potential patient-derived prostate organoids/xenografts, mouse models, advanced microscopy techniques, viral gene transfer-based genomic engineering, and CRISPR-Cas9-mediated genome editing as well as other molecular cell biology methods and functional genetics/genomics approaches.

PhD within molecular developmental biology – Nord University, Bodø, Norway

13.6.2019 | Avoimet työpaikat

https://www.researchgate.net/job/931235_PhD_within_molecular_developmental_biology

PhD fellowship is available at the Faculty of Biosciences and Aquaculture, Nord University (Bodø, Norway) on the project: Biogenesis and functions of small regulatory RNAs in embryonic development of zebrafish.

The position is for 3 years and will be available from August 1st. 2019.

The PhD is in molecular developmental biology, and zebrafish is the primary model. Regulation of early embryonic development is a multifaceted process involving many classes of regulatory elements. Ambiguity of developmental origin of these elements is a major difficulty in studying their functional roles This study combines functional genomics and high-throughput sequencing approaches in order to identify biogenesis, expression features, and roles of chosen elements. The focus is on two classes of small regulatory RNAs: miRNA and piRNA, which are both present in the early embryo yet their roles are poorly determined.

We offer

The annual salary for doctoral researchers is set from wage level 51 ( 449.400) in the Norwegian State Salary Scale.

  • Advantages within the Government Pension Fund for borrowing, insurance and pension
  • Creative and collegial working environment
  • A workplace with steady progressive development
  • Flexible working hours
  • Active university sports team

General information

The person who is appointed must abide by the applicable laws, agreements, and directives. The responsibilities and duties associated with the position may change with future reorganization at Nord University.

The public sector workforce is expected to reflect the diversity of the population in general. Nord University therefore encourages qualified candidates with disabilities, gaps in their CV, immigrant backgrounds or different life experience to apply. Nord University practices moderate allocation according to gender quotas in accordance with the Basic Agreement for State Employees.

If applicants indicate they have disabilities or gaps in their CV, their details may be used anonymously for the purposes of recording whether this target is achieved or not.

Contact information

Further information about the position can be obtained by contacting :

Professor Igor S. Babiak, e-mail: igor.s.babiak@nord.no, telephone: +47 75 51 79 22
Office Manager Irene Stork, e-mail: irene.stork@nord.no

Application

Applications must be submitted electronically by June 20th 2019.

The application should include:

  • Cover letter outlining the candidate’s suitability for this position (one page), and a project outline based on the project (maximum2 pages)
  • must be submitted.
  • Curriculum vitae, including a list of publications (maximum 3 pages)
  • Certified copies of academic degree transcripts and any other relevant qualifications
  • Contact details for 2 – 3 references
  • All documents must be uploaded as attachments to the electronic application form.
  • Signed consent form PhD (if relevant)

All documents must be uploaded as attachments to the electronic application form.

It is the applicant’s responsibility to submit the complete documentation within the deadline.

After the application deadline, an applicant list will be announced publicly. Applicants asking for confidentiality must specifically explain the reasons for this in their application. Even so, the information can be published if the reasons for confidentiality are not found relevant. In such the case, an applicant will be given notice prior to the announcement, and he/she will have opportunity to withdraw the application

Refnr. 30085016
Applicationdeadline: 20.06.2019

The candidate should have an MSc degree (or equivalent) in natural sciences, preferably in one of the following fields: Developmental Biology; Molecular Cell Biology; Genomics; Bioinformatics.Education and experience in one or more of the following areas is required: molecular developmental biology, RNA biology, transcriptomics, or genomics.Hands-on experience in RNA-seq, RNA bioinformatics, epigenomics, non-coding RNAs, or zebrafish development are advantageous for the position.Proficiency in oral and written English is essential and must be documented either by the Norwegian Higher Education Entrance Qualification or internationally recognised certificates, such as TOEFL, IELTS, APIEL or similar. Skills in Scandinavian language is an advantage for the position.The selected candidate will join the PhD programme in Aquatic Biosciences at Nord University and is expected to complete a doctorate within the three-year project period. The candidate should fulfill the admission requirements of this PhD programme at the Faculty of Biosciences and Aquaculture and participate in the training components stipulated in regulations of the PhD program. Application for admission to the programme must be submitted within three months after taking up the position. For admission requirements and regulations, see our see our web page.

Nord University

Global challenges demand new insight, innovative solutions and local legitimacy. Nord University is a young university with strong regional ties and a global perspective. We are committed to delivering relevant educational programmes and research, with a focus on blue and green growth, innovation and entrepreneurship, and welfare, health and education. Nord University has 12,000 students and 1,400 employees at nine study locations in central and northern Norway.The Faculty of Biosciences and Aquaculture (FBA) educates people who promote sustainable and innovative development to meet global challenges in food production, climate and environment. The Faculty is an international arena for education, research and knowledge dissemination, with employees and students from 25 different countries. The Faculty offers a PhD in Aquatic Biosciences. The Faculty of Biosciences and Aquaculture has 900 students and 150 employees in Bodø and Steinkjer. The professional community is organised into the following divisions: Aquaculture, Ecology, Genomics and Animal Science, Production and Welfare.Read more: www.nord.no/en/fba

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