Ajankohtaista

Molecular Modelling Mage – Orion

15.7.2021 | Avoimet työpaikat

https://www.orion.fi/en/careers/open-vacancies?rmpage=job&rmjob=1138&rmlang=UK

Orion Corporation operates in more than 20 countries, where we Orionees, 3200 in total, work in all kinds of positions. Among us there are Research Scientists, Laboratory Technicians, Engineers and IT Specialists as well as people working in Production, just to mention some examples. We offer diverse and responsible jobs to our personnel in a truly multi-disciplinary work environment. We encourage people to develop their competences and offer opportunities to affect the job description and creating their own career path at Orion. We are searching for top talents who are ready to share our passion for the work that we do.

Orion is seeking a Molecular Modelling Mage (an experienced Senior Scientist) to further develop  our capabilities and push the boundaries of theoretical drug discovery research carried out in Computational Medicine Design (CMD) unit.

Description of position

The Molecular Modelling Mage will work in the drug discovery projects linking and interfacing with biology and chemistry with both ab initio and data-driven perspectives. For this, it is critical to constantly rediscover the best suitable strategy for each project and define how to increase the target understanding and how to navigate the path of multiparameter optimization in modality design. For example, approaches can be both ligand- and structure-based virtual screening and design, protein modelling, physics-based simulations, structure-activity data analysis, machine learning and utilization of variety of in-house and public data sources. The Molecular Modelling Mage will collaborate closely with a broad range of scientists including other modellers in the CMD unit, medicinal chemists, pharmacologists and biologists.

The position is full-time and you will be based in Espoo or Turku, Finland.

Description of unit

Orion is a globally operating Finnish company listed on the Helsinki Stock Exchange. Orion develops, manufactures and markets human and veterinary pharmaceuticals, active pharmaceutical ingredients and diagnostic tests for global markets. Orion’s pharmaceutical innovations are created within its R&D organization, including e.g. non-clinical research, clinical development, formulation development and medical affairs. The organization employs top professionals in the field of drug molecule development and optimization.

Medicine Design contributes to the drug discovery process of Orion R&D from target validation all the way to the candidate nomination. We are responsible for translating new drug targets to therapeutical modalities together with other line functions. Our scientists in biology, chemistry and computer-aided medicine design are key players in the multiple research programs driven by Orion’s therapy areas of Neurological Disorders and Oncology. We also support our colleagues around R&D with our core competences.

Requirements

To be a successful Molecular Modelling Mage, you should have the following educational and professional work experiences:

  • Ph.D. from a suitable field, e.g. computational chemistry, bioorganic chemistry, biophysics, computer science or biochemistry
  • Concrete post-doctoral or industrial experience (above five years)
  • Broad experience in computational drug design, mastery of state-of-the-art ligand- and structure-based methods and their applications for medicine design
  • Solid understanding of fields relevant in the discovery process (e.g. medicinal chemistry, pharmacology, biochemistry, cell biology, structural biology, biophysics)

In addition, in depth experience in at least one of the following aspects:

  • Application of large-scale modern data science, machine learning and cheminformatics for drug discovery
  • Large-scale molecular dynamics simulations (e.g., relative and absolute free energy methods) for protein-ligand complexes
  • Track record of progressing modalities from hit identification through lead to clinical candidate

Experience with commercial molecular modelling software platforms, data pipelining tools (e.g. Knime) and programming/scripting/data analysis/data visualization (e.g. Python) is desirable.

We expect from all scientists the ability to work both independently and in multidisciplinary teams consisting of in-house scientists and external collaborators. A demonstrated record of research productivity and excellent oral and written communication skills in English are expected.

We offer

We offer you great, highly professional & experienced colleagues and the opportunity to show your talent and challenge yourself with interesting tasks in a modern multidisciplinary environment. Computational methods play a key role in Orion drug discovery so this is an opportunity to contribute to helping patients in need. Generous health and welfare benefits are available, as well as support for international relocation. Read more about R&D’s pipeline from here. 

Additional information

Is this the position you have been waiting for? Please send your cover letter and CV by 8th August 2021 and let us know what inspires you! Our application period is extended due to holiday period in Finland.

For additional information on the position, please contact Heikki Käsnänen, Head of Computational Medicine Design, +358104265279, during the following times: July 8th and 9th: 11 AM to 2 PM (EEST).

#LI-ORION

Approved medical examination which also includes drug testing is required prior to the employment. We will also carry out a security clearance prior to the employment for the selected person.

QC Manager – FinVector Oy

15.7.2021 | Avoimet työpaikat

https://www.sympahr.net/public/pq.aspx?816287c9&lang=en-US

We are looking for a QC Manager to lead and reinforce our Quality Control team.

Suitable candidate has previous experience in managing people and analytical lab work. Understanding of quality systems and pharmaceutical industry are seen as a plus.

Your main responsibilities include managing the overall work of the QC department and overseeing QC activities. As QC Manager you are establishing priorities, monitoring the progress of all assigned tasks, allocating resources and ensuring that the tasks meet milestones and deadlines.  

You could be the person if…

You are able to set direction, define suitable course of action, and delegate responsibilities in a practical manner. Moreover, you are proficient at planning, efficient in time management and good at organizing needed resources.

You are able to make clear decisions and take responsibility over tasks and people

You are resourceful and able to apply your expertise in QC activities. You share your knowledge to the team and organization.

You are able to work in a systematic and strategic manner to achieve objectives. You are able to see future prospects and have overall vision of your own responsibility area.

You are good at building relations within the organization and you find it easy to communicate at all levels of the organization. You understand different functions in the organization and the links between them.

Most importantly, as QC Manager you need to inspire, support and develop your team!

In order to succeed, you would need a degree in the field of laboratory, bioanalytics, cell biology, biochemistry or any other related field of study. You also need to communicate fluently both in written and spoken English.

The position is permanent and we hope that you are able to join our team in September. This role is new in our organization due to our ongoing growth.

We offer you an active and lively work community with diverse staff. We provide you occupational health-care and we support your well-being by ePassi-account. Furthermore, we will support your personal development.

Please apply by 1.8.2021!

For more information, please contact Anna-Kaisa Lehtivarjo, tel. 050-3407250. You’ll reach Anna-Kaisa from 19.7. on during office hours.


Analytical Development Scientist – FinVector Oy

15.7.2021 | Avoimet työpaikat

https://www.sympahr.net/public/pq.aspx?c5795d9c&lang=en-US

We are looking for Analytical Development Scientist to our growing MSAT team.

MSAT stands for Manufacturing, Science and Technology. At MSAT we have three core functions that oversee Analytical development, Manufacturing process development and Chemistry, Manufacturing and Controls (CMC) management.

The Analytical Development team is in charge of development, optimization and validation of new analytical procedures and/or optimization of the current established ones. MSAT also supports regulatory filings to enable robust clinical and commercial supply, health authority communication, due diligence and business development opportunities. 

Your primary responsibility as an Analytical Development Scientist is to be a Subject Matter Expert (SME) for assigned assays. You will focus on assay development by using analytical models to support root cause investigations and evaluating process improvements.

It is an advantage if you already have some experience of GMP-work and/or you are familiar with quality systems. Moreover, experience in cell culture assays will help you to get into the work more easily.

You could be the person if…

You produce clear, easily understandable and accurate documentation in English.

You have good skills in analyzing data, both verbal and numeric. You are also seeking new information to solve challenges and make decisions based on the data.

You are able to innovate new ideas, approaches and views. You also enjoy developing yourself.

Your work approach is precise and you achieve objectives set to you in a timely manner.

In order to succeed, you would need a degree in the fields of biosciences, cell biology, chemistry, biochemistry, biotechnology or any other related field of study.

As a person, we would like you to be open-minded towards new challenges and spread good team spirit. You also need to communicate fluently both in written and spoken English.

We hope you to start in September 2021.

We offer you active and lively work community with highly skilled and experienced personnel in gene therapy manufacturing. Working with us, you are entitled to good employment benefits, such as extensive occupational health-care and ePassi- account. We provide you a wide induction training and a warm welcome.

Apply by 1.8.2021!

For more information, please contact Minna Hassinen, tel. 050-4336447. You’ll reach Minna 8.-16.7.2021 during office hours.