Ajankohtaista

Postdoctoral Research Fellow, (Functional RNAomics), 2 positions

14.12.2021 | Avoimet työpaikat

https://tuni.rekrytointi.com/paikat/?o=A_RJ&jgid=1&jid=1210

The Functional RNAomics laboratory at the Faculty of Medicine and Health Technology, Tampere University studies gene regulation via RNA processing. By determining how RNA regulation is orchestrated in different cell types, we aim to crack the cellular RNA code and gain critical insights into how aberrations in the RNA machinery result in genetic disorders and cancer. RNA is emerging as a powerful and easily adaptable therapeutic molecule as exemplified by the rapid development of effective mRNA vaccines but a detailed knowledge of RNA regulation in cells is a prerequisite to realise the full potential of RNA-based therapeutic and diagnostic development. We integrate cell biology approaches with mechanistic studies, global mapping of RNA repertoires, RNA binding protein interactions and proteomics profiles to reveal the functional role of RNA-protein complexes in different cell lineages and in disease.

Job description

We are looking for two post-doctoral researchers on full- or part-time basis:

  1. The postdoctoral researcher in cell and molecular biology will conduct experimental research involving advanced molecular biology techniques including sample preparation for short-read and long-read RNA sequencing, cell and organoid cultures, and various biochemistry methods. The work involves experimental planning, detailed recording of data, data analysis and reporting of results.
  2. The post-doctoral research in bioinformatics will analyse a range of large-scale datasets including short-read RNA sequencing, long-read direct RNA sequencing and proteomics data. The work includes the application of existing data analysis pipelines as well as the development of new computational methods. It also involves experimental planning, detailed recording of data and reporting of results.

Requirements

The positions are mostly intended for recently graduated researchers, so that they may gain further experience and advance their careers. You should have a PhD degree in biochemistry, genetics, molecular biology, bioinformatics/computational biology or a related subject area. We expect a competence to pursue independent scientific work. You should be fluent in spoken and written English and have a solid experience either in (1) cell and molecular biology or (2) computational biology/bioinformatics. Skills in both wet and dry lab research are considered an advantage. 

You should be able to communicate with experimental and computational biologists as a member of a multidisciplinary team. We appreciate experience of studying or working abroad and contacts to international research community. We are looking for versatile and independent researchers with experience in the closely related area of the positions. It is expected that you will be able to contribute to the supervision of M.Sc. and Ph.D. students. Please be prepared to provide a proof of your merits when requested.

Tampere University is a unique, multidisciplinary and boldly forward-looking, evolving community. Our values are equity, openness, diversity, responsibility, courage, critical thinking, erudition bildung, and learner-centredness. We hope that you can embrace these values and promote them in your work.

We offer

The position will be filled for a fixed-term period of 2 years in the first instance. The starting date is 1st February 2022 or as mutually agreed. A trial period of six months applies to all our new employees.

The salary will be based on both the job requirements and the employee’s personal performance in accordance with the Finnish University Salary System. The position of a Postdoctoral Researcher is placed on the job demands levels 5-6 (teaching and research staff). 

We offer a wide range of staff benefits, such as occupational health care, flexible working hours, excellent sports facilities on campus and several restaurants and cafés on campus with staff discounts. Please read more about working at Tampere University.

We offer a world-class research environment in an internationally recognized research group. We have strong collaborative networks and offer great opportunities for researchers to develop their careers in an international setting.

How to apply

Please submit your application through our online recruitment system. The closing date for applications is 10th December 2021 (at 23.59 EET /UTC+2). Please write your application and all accompanying documents in English and attach them in PDF format.

The closing date for applications has been extended until 20 December, 2021.

Applications should include the following documents:

  • Curriculum Vitae according to TENK guidelines
  • List of publications according to Academy of Finland guidelines
  •  References from two people
  •  Motivation letter (1-2 pages) 
  • Description of your research focus, qualifications, previous research fields and main research achievements (1-2 pages)

For more information, please contact:

Professor, Group Leader Minni Änkö, minna-liisa.anko (at) tuni.fi

***

Tampereen yliopisto ja Tampereen ammattikorkeakoulu muodostavat yhdessä Suomen toiseksi suurimman monitieteisen, innostavan ja vaikuttavan tutkimus- ja oppimisyhteisön. Korkeakouluyhteisömme osaamiskärjet ovat tekniikka, terveys ja yhteiskunta. Lue lisää: www.tuni.fi 

Functional RNAomics -tutkimusryhmä Tampereen yliopiston Lääketieteen ja terveysteknologian tiedekunnassa tutkii RNA-välitteistä geenien säätelyä. Tutkimuksemme tavoitteena on selvittää, miten RNA-tason säätely toimii eri solutyypeissä. Tarkoituksenamme on ‘murtaa solujen RNA-koodi’ ja siten ymmärtää, mikä RNA-säätelyn rooli on geneetisien sairauksien ja syövän synnyssä. RNA on osoittautunut monimuotoiseksi molekyyliksi, jota voidaan soveltaa erilaisten sairauksien hoidossa tai ehkäisyssä, esimerkkinä hiljattain kehitetyt RNA-rokotteet. Jotta RNA:ta voidaan turvallisesti hyödyntää diagnostiikassa ja hoitomuotona, meidän täytyy kuitenkin ensin selvittää, kuinka RNA-säätely toimii solutasolla. Yhdistämme tutkimuksessamme erilaisia solu- ja molekyylibiologian menetelmiä sekä RNA- ja proteomitason profilointia.

Tehtävänkuvaus

  1. Tutkijatohtori/solu- ja molekyylibiologia: molekyyli- ja solubiologian tutkimuksen suunnitteleminen, laboratoriatehtävät mukaan lukien soluviljely, sekvenointikirjastojen valmistaminen erilaisiin RNA-sekvenointisovelluksiin sekä erilaiset biokemian menetelmät, tulosten analysointi ja raportointi.
  2. Tutkijatohtori/bioinformatiikka: RNA-sekvenointi- ja proteomidatan analysointi käyttäen olemassaolevia menetelmiä, uusien analyysimenetelmien kehittäminen, tulosten reportointi.

Tutkimusryhmän työkieli on englanti, joten sujuva englanninkielen taito on välttämätön. Tutkijatohtorin tehtäviin kuuluu nuorempien tutkijoiden ja opiskelijoiden ohjaus. 

Hakuohjeet

Lue tarkemmat tiedot tehtävästä ja hakuohjeet yllä olevasta englanninkielisestä ilmoituksesta.

Jätäthän hakemuksesi yliopiston sähköisellä hakulomakkeella (linkki löytyy tämän ilmoituksen alta).

Hakuaika tehtävään päättyy 10.12.2021 klo 23.59.

Hakuaikaa jatkettu 20.12.2021 klo 23.59 asti.

Postdoctoral Research Fellow, (Functional RNAomics) – 2 positions

12.11.2021 | Avoimet työpaikat

https://tuni.rekrytointi.com/paikat/?o=A_RJ&jgid=1&jid=1210

The Functional RNAomics laboratory at the Faculty of Medicine and Health Technology, Tampere University studies gene regulation via RNA processing. By determining how RNA regulation is orchestrated in different cell types, we aim to crack the cellular RNA code and gain critical insights into how aberrations in the RNA machinery result in genetic disorders and cancer. RNA is emerging as a powerful and easily adaptable therapeutic molecule as exemplified by the rapid development of effective mRNA vaccines but a detailed knowledge of RNA regulation in cells is a prerequisite to realise the full potential of RNA-based therapeutic and diagnostic development. We integrate cell biology approaches with mechanistic studies, global mapping of RNA repertoires, RNA binding protein interactions and proteomics profiles to reveal the functional role of RNA-protein complexes in different cell lineages and in disease.

Job description

We are looking for two post-doctoral researchers on full- or part-time basis:

  1. The postdoctoral researcher in cell and molecular biology will conduct experimental research involving advanced molecular biology techniques including sample preparation for short-read and long-read RNA sequencing, cell and organoid cultures, and various biochemistry methods. The work involves experimental planning, detailed recording of data, data analysis and reporting of results.
  2. The post-doctoral research in bioinformatics will analyse a range of large-scale datasets including short-read RNA sequencing, long-read direct RNA sequencing and proteomics data. The work includes the application of existing data analysis pipelines as well as the development of new computational methods. It also involves experimental planning, detailed recording of data and reporting of results.

Requirements

The positions are mostly intended for recently graduated researchers, so that they may gain further experience and advance their careers. You should have a PhD degree in biochemistry, genetics, molecular biology, bioinformatics/computational biology or a related subject area. We expect a competence to pursue independent scientific work. You should be fluent in spoken and written English and have a solid experience either in (1) cell and molecular biology or (2) computational biology/bioinformatics. Skills in both wet and dry lab research are considered an advantage. 

You should be able to communicate with experimental and computational biologists as a member of a multidisciplinary team. We appreciate experience of studying or working abroad and contacts to international research community. We are looking for versatile and independent researchers with experience in the closely related area of the positions. It is expected that you will be able to contribute to the supervision of M.Sc. and Ph.D. students. Please be prepared to provide a proof of your merits when requested.

Tampere University is a unique, multidisciplinary and boldly forward-looking, evolving community. Our values are equity, openness, diversity, responsibility, courage, critical thinking, erudition bildung, and learner-centredness. We hope that you can embrace these values and promote them in your work.

We offer

The position will be filled for a fixed-term period of 2 years in the first instance. The starting date is 1st February 2022 or as mutually agreed. A trial period of six months applies to all our new employees.

The salary will be based on both the job requirements and the employee’s personal performance in accordance with the Finnish University Salary System. The position of a Postdoctoral Researcher is placed on the job demands levels 5-6 (teaching and research staff). 

We offer a wide range of staff benefits, such as occupational health care, flexible working hours, excellent sports facilities on campus and several restaurants and cafés on campus with staff discounts. Please read more about working at Tampere University.

We offer a world-class research environment in an internationally recognized research group. We have strong collaborative networks and offer great opportunities for researchers to develop their careers in an international setting.

How to apply

Please submit your application through our online recruitment system. The closing date for applications is 10th December 2021 (at 23.59 EET /UTC+2). Please write your application and all accompanying documents in English and attach them in PDF format.

Applications should include the following documents:

  • Curriculum Vitae according to TENK guidelines
  • List of publications according to Academy of Finland guidelines
  •  References from two people
  •  Motivation letter (1-2 pages) 
  • Description of your research focus, qualifications, previous research fields and main research achievements (1-2 pages)

For more information, please contact:

Professor, Group Leader Minni Änkö, minna-liisa.anko (at) tuni.fi

***

Tampereen yliopisto ja Tampereen ammattikorkeakoulu muodostavat yhdessä Suomen toiseksi suurimman monitieteisen, innostavan ja vaikuttavan tutkimus- ja oppimisyhteisön. Korkeakouluyhteisömme osaamiskärjet ovat tekniikka, terveys ja yhteiskunta. Lue lisää: www.tuni.fi 

Functional RNAomics -tutkimusryhmä Tampereen yliopiston Lääketieteen ja terveysteknologian tiedekunnassa tutkii RNA-välitteistä geenien säätelyä. Tutkimuksemme tavoitteena on selvittää, miten RNA-tason säätely toimii eri solutyypeissä. Tarkoituksenamme on ‘murtaa solujen RNA-koodi’ ja siten ymmärtää, mikä RNA-säätelyn rooli on geneetisien sairauksien ja syövän synnyssä. RNA on osoittautunut monimuotoiseksi molekyyliksi, jota voidaan soveltaa erilaisten sairauksien hoidossa tai ehkäisyssä, esimerkkinä hiljattain kehitetyt RNA-rokotteet. Jotta RNA:ta voidaan turvallisesti hyödyntää diagnostiikassa ja hoitomuotona, meidän täytyy kuitenkin ensin selvittää, kuinka RNA-säätely toimii solutasolla. Yhdistämme tutkimuksessamme erilaisia solu- ja molekyylibiologian menetelmiä sekä RNA- ja proteomitason profilointia.

Tehtävänkuvaus

  1. Tutkijatohtori/solu- ja molekyylibiologia: molekyyli- ja solubiologian tutkimuksen suunnitteleminen, laboratoriatehtävät mukaan lukien soluviljely, sekvenointikirjastojen valmistaminen erilaisiin RNA-sekvenointisovelluksiin sekä erilaiset biokemian menetelmät, tulosten analysointi ja raportointi.
  2. Tutkijatohtori/bioinformatiikka: RNA-sekvenointi- ja proteomidatan analysointi käyttäen olemassaolevia menetelmiä, uusien analyysimenetelmien kehittäminen, tulosten reportointi.

Tutkimusryhmän työkieli on englanti, joten sujuva englanninkielen taito on välttämätön. Tutkijatohtorin tehtäviin kuuluu nuorempien tutkijoiden ja opiskelijoiden ohjaus. 

Hakuohjeet

Lue tarkemmat tiedot tehtävästä ja hakuohjeet yllä olevasta englanninkielisestä ilmoituksesta.

Jätäthän hakemuksesi yliopiston sähköisellä hakulomakkeella (linkki löytyy tämän ilmoituksen alta).

Hakuaika tehtävään päättyy 10.12.2021 klo 23.59.