Ajankohtaista

Molecular Modelling Mage – Orion

15.7.2021 | Avoimet työpaikat

https://www.orion.fi/en/careers/open-vacancies?rmpage=job&rmjob=1138&rmlang=UK

Orion Corporation operates in more than 20 countries, where we Orionees, 3200 in total, work in all kinds of positions. Among us there are Research Scientists, Laboratory Technicians, Engineers and IT Specialists as well as people working in Production, just to mention some examples. We offer diverse and responsible jobs to our personnel in a truly multi-disciplinary work environment. We encourage people to develop their competences and offer opportunities to affect the job description and creating their own career path at Orion. We are searching for top talents who are ready to share our passion for the work that we do.

Orion is seeking a Molecular Modelling Mage (an experienced Senior Scientist) to further develop  our capabilities and push the boundaries of theoretical drug discovery research carried out in Computational Medicine Design (CMD) unit.

Description of position

The Molecular Modelling Mage will work in the drug discovery projects linking and interfacing with biology and chemistry with both ab initio and data-driven perspectives. For this, it is critical to constantly rediscover the best suitable strategy for each project and define how to increase the target understanding and how to navigate the path of multiparameter optimization in modality design. For example, approaches can be both ligand- and structure-based virtual screening and design, protein modelling, physics-based simulations, structure-activity data analysis, machine learning and utilization of variety of in-house and public data sources. The Molecular Modelling Mage will collaborate closely with a broad range of scientists including other modellers in the CMD unit, medicinal chemists, pharmacologists and biologists.

The position is full-time and you will be based in Espoo or Turku, Finland.

Description of unit

Orion is a globally operating Finnish company listed on the Helsinki Stock Exchange. Orion develops, manufactures and markets human and veterinary pharmaceuticals, active pharmaceutical ingredients and diagnostic tests for global markets. Orion’s pharmaceutical innovations are created within its R&D organization, including e.g. non-clinical research, clinical development, formulation development and medical affairs. The organization employs top professionals in the field of drug molecule development and optimization.

Medicine Design contributes to the drug discovery process of Orion R&D from target validation all the way to the candidate nomination. We are responsible for translating new drug targets to therapeutical modalities together with other line functions. Our scientists in biology, chemistry and computer-aided medicine design are key players in the multiple research programs driven by Orion’s therapy areas of Neurological Disorders and Oncology. We also support our colleagues around R&D with our core competences.

Requirements

To be a successful Molecular Modelling Mage, you should have the following educational and professional work experiences:

  • Ph.D. from a suitable field, e.g. computational chemistry, bioorganic chemistry, biophysics, computer science or biochemistry
  • Concrete post-doctoral or industrial experience (above five years)
  • Broad experience in computational drug design, mastery of state-of-the-art ligand- and structure-based methods and their applications for medicine design
  • Solid understanding of fields relevant in the discovery process (e.g. medicinal chemistry, pharmacology, biochemistry, cell biology, structural biology, biophysics)

In addition, in depth experience in at least one of the following aspects:

  • Application of large-scale modern data science, machine learning and cheminformatics for drug discovery
  • Large-scale molecular dynamics simulations (e.g., relative and absolute free energy methods) for protein-ligand complexes
  • Track record of progressing modalities from hit identification through lead to clinical candidate

Experience with commercial molecular modelling software platforms, data pipelining tools (e.g. Knime) and programming/scripting/data analysis/data visualization (e.g. Python) is desirable.

We expect from all scientists the ability to work both independently and in multidisciplinary teams consisting of in-house scientists and external collaborators. A demonstrated record of research productivity and excellent oral and written communication skills in English are expected.

We offer

We offer you great, highly professional & experienced colleagues and the opportunity to show your talent and challenge yourself with interesting tasks in a modern multidisciplinary environment. Computational methods play a key role in Orion drug discovery so this is an opportunity to contribute to helping patients in need. Generous health and welfare benefits are available, as well as support for international relocation. Read more about R&D’s pipeline from here. 

Additional information

Is this the position you have been waiting for? Please send your cover letter and CV by 8th August 2021 and let us know what inspires you! Our application period is extended due to holiday period in Finland.

For additional information on the position, please contact Heikki Käsnänen, Head of Computational Medicine Design, +358104265279, during the following times: July 8th and 9th: 11 AM to 2 PM (EEST).

#LI-ORION

Approved medical examination which also includes drug testing is required prior to the employment. We will also carry out a security clearance prior to the employment for the selected person.

Research and Senior Scientists, Protein Production (Fixed-term)

1.6.2021 | Avoimet työpaikat

https://tyopaikat.loimu.fi/tyopaikat/?kategoria0=Kemia%20ja%20life%20science&sivu=1

Do you want to join us to develop new biotechnology and microbial systems for protein production?

We are looking for ambitious and customer-oriented Research Scientist and Senior Scientist (two positions) with a background inprotein production systems and fungal biology.

As a researcher at our Protein Production Team, you will have a key role and an opportunity to work on topics of great importance to society such as production of sustainable, animal free food proteins, production of vaccines to reduce antibiotics use in animals, enzyme mixtures for biofuel production, and therapeutic proteins for human medicine. You have the opportunity to work together with different customers ranging from big companies to start-ups and to support them in solving challenges with the help of science and technology.

Read more about our work in the following articles:

Eggs without chickens, milk without cows?

New fungal production platform C1 for vaccines and therapeutic proteins

With us you will be responsible for

  • Scientific project work in the fields of protein production systems and fungal biology
  • Writing scientific reports and presenting research data
  • Working with customers to help them solve challenges 

We expect you to have

  • Completed MSc or PhD in relevant field
  • Excellent laboratory skills and experience in molecular biology techniques
  • Experience working with yeast or filamentous fungi
  • Strong spoken and written English skills

As you person you are

  • Motivated and willing to take initiative in getting projects accomplished
  • You have strong communication skills
  • Able to work both independently and as a member of a team
  • Curious towards various scientific and technological challenges
  • Willing to travel to customer and scientific meetings 

We offer

At VTT, we believe that our impact is built on scientific and technological excellence in all our work. Our personnel are at the core of VTT, where wellbeing and competence development are key priorities. You will be a part of a creative and international working environment. The tasks are versatile, independent and challenging, with support and coaching where needed.

We offer this excellent opportunity to work with an experienced research team to better understand and develop fungal protein production hosts used for production of proteins and enzymes used in food, feed, biofuels, animal care, textiles, and human medicine.

Further information

For more information about the position, you can contact Chris Landowski, Research Team Leader, Protein Production, christopher.landowski@vtt.fi

These are two years fixed-term positions.

You can find more information about the team and the projects:

VTT Finland-Protein Production Team

VTT develops piglet vaccination to reduce antibiotics use

We are looking forward to hearing from you, so please send your CV and application as soon as possible, or June 16th at the latest!

Senior Bioinformatics Scientist

24.5.2021 | Avoimet työpaikat

https://careers.blueprintgenetics.com/jobs/1180935-senior-bioinformatics-scientist

Blueprint Genetics is a leading clinical genetic testing company aspiring to bring world-class genetic knowledge to mainstream healthcare. We are growing rapidly and strengthening the core of our diagnostics where we utilise Next-Generation Sequencing (NGS) technologies, which produce large quantities of data, requiring highly efficient computing infrastructure and data analysis pipelines. To support our rapid growth and constant strive for state-of-the-art analytic solutions, we are looking for a Senior Bioinformatics Scientist to join our Bioinformatics R&D team in Espoo, Finland.

Job Description

In this position you will be part of the Bioinformatics R&D team, and will also work closely with our Clinical Bioinformatics, Software Development, Data Science and IT Operations teams. You work as part of a team of domain experts combining independent tasks and teamwork. You are fully comfortable with modern software development process and share the common practices and responsibilities with the rest of the team.

Your main tasks will include:

  • Combining your NGS data-analysis and programming skills to further develop and maintain our state-of-the-art analysis pipelines and tools, leveraging the power of workflow management frameworks in the cloud
  • Facilitating the adoption of cutting-edge bioinformatics methods and data sources into NGS analyses in a clinical diagnostics setting
  • The evaluation and development of NGS methods
  • Participating in our scientific projects and helping to ensure that our clinical bioinformatics production efficiently utilises state-of-the-art methods and technologies

What we expect from you

We are hoping to find an open and collaborative team member who is eager to learn from others and comfortable acting as an opinion leader in their areas of strength. You possess both a strong practical skillset for NGS data analysis and a broad theoretical background either from academia or industry. You strive for high quality and appreciate the amount of care working with clinical data requires. We hope you are looking for meaningful work and share our passion for making an impact in people’s lives. We aspire to find a colleague who fits our easy-going team of skilled and knowledgeable professionals. Our ideal candidate has:

  • An MSc degree in Bioinformatics, Computational Science or related field
  • A minimum of 4 years of working experience in bioinformatics research, developing data-analysis pipelines and/or software solutions in the field of NGS/Bioinformatics
  • Deep understanding of bioinformatics as a field and its different applications
  • Excellent communication skills in both written and spoken English
  • Strong teamwork skills and the motivation to learn from others

What differentiates you

  • A PhD degree in bioinformatics, computer science, human genetics or related field
  • Academic background with track-record of published scientific papers, methods, databases and tools within the field of bioinformatics and genetics
  • Knowledge of bioinformatic workflow languages
  • Thorough experience working with Whole Genome Sequencing (WGS) and Whole Exome Sequencing (WES)
  • Experience with statistical analysis, data engineering and machine learning
  • Cloud computing experience
  • Background in clinical diagnostics

What we offer

At Blueprint Genetics, you’ll be a valued part of our global team of creative and solution-oriented people. You will get to work at the forefront of health and life sciences. We offer you rewarding work in a rapidly evolving environment, where you can learn and grow together with the company. Through your work you will help us in our mission to provide world-class, scalable solutions that will take genetic testing from niche to mainstream healthcare – to the benefit of patients worldwide.

How to apply

Does this sound like your next career move? All you need to do is submit your CV or share your LinkedIn profile with us through our online form at the latest on June 20. The first round of discussions will be carried out virtually. We hope to hear from you soon!

If you have any further questions about the position, you can contact our Bioinformatics R&D Manager Ville Kytölä, ville.kytola@blueprintgenetics.com

Who we are

We are a specialty genetics and bioinformatics company focused on providing genetic testing for inherited diseases. We are based in Keilaniemi (Espoo), Finland, and Seattle, WA, with a customer base spanning over 70 countries. www.blueprintgenetics.com

Blueprint Genetics is a Quest Diagnostics company. Quest Diagnostics is the world’s leading provider of diagnostic information services. www.questdiagnostics.com