5.11.2025 | Avoimet työpaikat
Apply latest by 9.11.
https://duunitori.fi/tyopaikat/tyo/senior-scientist-target-discovery-adc-sosri-19709899?utm_source=loimu&utm_medium=site
Job description
About the Role
Orion Pharma is making strategic investments in challenging R&D areas where our expertise can drive breakthroughs-particularly in cancer therapies. As part of this commitment, we are enhancing our oncology research capabilities by establishing dedicated Target Discovery teams within each of our oncology research units: Immuno-Oncology, Antibody Drug Conjugates (ADC), and Cancer Genomics.
We are looking for a motivated and skilled Senior Scientist to join Antibody-Drug Conjugates (ADC) Target Discovery Team. The ideal candidate has strong experience in preclinical cancer research and a solid background in cell and molecular cancer biology, with exposure to bioinformatics.
Key Responsibilities
- Design and execute strategies for identifying novel ADC targets using data-driven and lab-based approaches.
- Run ADC targets validation
- Conduct and/or coordinate experiments to assess ADC potency and safety.
- Provide expert guidance in cancer biology to project teams.
- Collaborate with internal teams (bioinformatics, chemistry, biology, pharmacology, clinical) to solve scientific challenges.
- Propose and manage research activities with strategic partners, CROs, and academic collaborators.
- Maintain detailed lab records and documentation.
- Analyse experimental data and present findings in meetings.
You will work closely with a multidisciplinary team to discover and validate novel cancer targets and help develop first- or best-in-class ADCs from concept to clinical candidate. This is a unique opportunity to contribute to cutting-edge cancer therapies that can make a real difference for patients.
You will be located in Turku, Finland, and will report to the ADC Target Discovery Lead. This is a full-time, permanent and on-site position. Orion Pharma will support relocation to Finland.
What We Offer
- A chance to work with experienced scientists across Orion’s R&D.
- A dynamic and supportive work environment with opportunities for growth.
- The opportunity to contribute to innovative therapies that improve patients’ lives.
At Orion Pharma, your work creates true impact and well-being for our customers, patients and society at large. Our culture of friendliness, respect, mutual appreciation and diversity creates a safe working environment where you can strive for excellence. We offer a wealth of career paths and development opportunities that support the development of innovative solutions and improving the quality of life.
Please visit our website to find further information about our values and Orion as an employer https://www.orion.fi/en/careers/orion-as-an-employer/ .
Our expectations
Essential competences, education and way of working :
- MS, or PhD in Biological Sciences, Biochemistry or closely related field with typically 10+ (MS) or 4+ (PhD) years of postdoc or industry related experience.
- Strong understanding and experience of cancer biology, cell and molecular biology, and biochemistry.
- Practical experience with bioinformatics and omics data (transcriptomics, proteomics, spatial data) and analysis (e.g. online tools, R or Python).
- Hands-on experience with lab techniques: cell surface proteins labelling and analysis, flow cytometry, microscopy, cytotoxicity assays, qPCR, western blotting, and ELISA.
- Experience with 2D and 3D cell culture models.
- Demonstrated ability to work independently and lead research activities.
- Strong interest in adopting new technologies and methods.
- Excellent problem-solving, communication, and organizational skills.
How to apply and additional information
Please send your application with the latest CV, cover letter, and salary request in English by 9th of November 2025. Please note that we will start reviewing applications during the application period.
For additional details, do not hesitate to contact Antti Arjonen, ADC Target Discovery Lead, +358 40 721 9109 on any of the following times (Finnish Time): 5th Nov between 9am-4pm and 6th Nov between 9am-1pm (EET).
#LI-ORION
Approved medical examination which also includes drug testing is required prior to the employment. We will also carry out a security clearance prior to the employment for the selected person.
Unit description
Orion Pharma’s pharmaceutical innovations are created within its R&D organization. We employ around 400 top professionals in the field of drug discovery and development. We work globally: in Espoo and Turku in Finland, in Cambridge and Nottingham in England and in New York, NY, USA. Orion R&D and the Innovative Medicines business division are dedicated to making a transformation to become a global player in the pain and oncology therapy areas.
Target Discovery Team is part of the Antibody-Drug Conjugates (ADC) Research Group, one of three scientific units within Oncology Research, a division of Orion’s R&D Organization. Our team is dedicated to the discovery and validation of therapeutic ADC targets, leveraging omics technologies alongside a broad array of biophysical, biochemical, molecular, cellular, and in vivo methods. We strive to develop cutting-edge ADC therapies with the potential to transform the lives of cancer patients.
About Us
Orion Pharma is a globally operating Nordic pharmaceutical company – a builder of well-being for over a hundred years.
We’re home to more than 4,000 Orionees around the world, and we’re proud to be known as a responsible employer and a great place to work. At Orion Pharma, people are truly valued and trusted, encouraged to grow, and supported by a culture where every voice is heard. We appreciate each other, strive for excellence, and build the future.
Together we develop, manufacture, and market human and veterinary pharmaceuticals and active pharmaceutical ingredients. Our extensive portfolio includes proprietary and generic medicines as well as consumer health products. The core therapy areas of our pharmaceutical R&D are oncology and pain. Proprietary products developed by Orion Pharma are used to treat cancer, neurological diseases, respiratory diseases, and more.
We offer careers with a clear purpose: empowering people to live their lives to the fullest.
31.10.2024 | Avoimet työpaikat
https://duunitori.fi/tyopaikat/tyo/postdoctoral-research-fellow-translational-leukemia-research-tutkijatohtori-translationaalinen-stsam-18681352?utm_source=loimu&utm_medium=site
Apply latest by 4.11.
Tampere University and Tampere University of Applied Sciences create a unique environment for multidisciplinary, inspirational and high-impact research and education. Our university community has its competitive edges in technology, health and society. www.tuni.fi/en .
The Hemato-oncology Research Group (HemoRES) at Faculty of Medicine and Health Technologyis looking for a Postdoctoral Research Fellow specializing in translational leukemia research. The research group works under the Tampere Center for Child, Adolescent and Maternal Health Research (TamCAM). The position is full-time and will be filled for a fixed-term period of three years.
The Hemato-oncology research group studies the molecular mechanisms underlying childhood acute lymphoblastic leukemia (ALL), aiming to develop novel, mechanism-based targeted therapies. Our approach combines a variety of genomic and molecular analyses, drug screening, patient samples, and disease modeling using both cellular and animal systems, including zebrafish.
The Faculty of Medicine and Health Technology (MET) is committed to high quality research and education in the fields of biomedical engineering, biotechnology, medicine, and health technology. We conduct basic, applied, clinical, and translational research in collaboration with Tampere University Hospital (TAYS). Our existing research areas in health research include biomedical engineering fields from biomaterials and microtechnologies to health data science, cell and molecular biology, with applications in areas such as cancer, cardiovascular and celiac diseases, immunology, and ophthalmology.
Job description
We are looking for a talented and motivated postdoctoral researcher to join a project led by Prof. Olli Lohi. The project, funded by the Jane & Aatos Erkko Foundation, focuses on developing targeted therapies for T-cell acute lymphoblastic leukemia (T-ALL). Our research aims to identify novel and effective combination treatments for T-ALL, enhance immunotherapies, and investigate the mechanisms of drug resistance. The work involves the use of cell lines, patient samples, zebrafish models, and a variety of cellular, molecular, and genome-wide assays.
Requirements
We are seeking a versatile and independent researcher with experience and a proven track record-such as published work or a thesis-in a wide range of cellular and molecular biology techniques, including cell culture, drug testing, CRISPR/Cas9 gene editing, and data analysis (e.g., NGS data, R software). Prior experience with leukemia research or zebrafish experimentation would be appreciated.
- Applicable doctoral degree in the field, e.g. Molecular and Cellular Biology, Immunology, Cancer Biology, or Genomics
- High motivation and a strong research orientation
- The ability to work independently, and stay current with relevant literature
- Strong interpersonal and networking skills, along with a willingness to mentor junior researchers
- Fluency in spoken and written English.
Tampere University is a unique, multidisciplinary, and boldly forward-looking community. Our values are openness, diversity, responsibility, courage, critical thinking, and learner-centredness. We hope that you can embrace these values and promote them in your work.
We offer
The position will be filled for a fixed-term period of three years, starting on 1 January 2025 or as mutually agreed. A trial period of six months applies to all our new employees.
The salary will be based on both the job requirements and the employee’s personal performance in accordance with the Finnish University Salary System. The position of a Postdoctoral Researcher is placed on the job demands levels 5-6 (teaching and research staff). A typical starting salary of Postdoctoral Researcher is around 3500-3800 EUR/month.
We offer a world-class research environment in internationally recognized research groups. We have strong collaborative networks and offer great opportunities for researchers to develop their careers in an international setting. We offer you the opportunity to join our dynamic and innovative international community.
As a member of staff at Tampere University, you will enjoy a range of competitive benefits, such as occupational health care services, flexible work schedule, versatile research infrastructure, modern teaching facilities and a safe and inviting campus area as well as a personal fund to spend on sports and cultural activities in your free time. Please read more about working at Tampere University. You can also find more information about us and working and living Tampere by watching our video: Tampere Higher Education Community – our academic playground.
Finland is among the most stable, free and safe countries in the world, based on prominent ratings by various agencies. Tampere is the largest inland city of Finland, and the city is counted among the major academic hubs in the Nordic countries. Tampere region is the most rapidly growing urban area in Finland and home to a vibrant knowledge-intensive entrepreneurial community. The city is an industrial powerhouse that enjoys a rich cultural scene and a reputation as a centre of Finland’s information society. Tampere is also surrounded by vivid nature with forests and lakes, providing countless opportunities for easy-to-access outdoor adventures and refreshment throughout the year.
Read more about Finland and Tampere:
How to apply
Please submit your application through our online recruitment system. The closing date for applications is 4 November 2024 (23:59 EET / UTC +2). Please write your application and all accompanying documents in English and attach them in PDF format.
Applications should include the following documents:
For more information, please contact:
Professor Olli Lohi, olli.lohi@tuni.fi
With questions related to the recruitment process, please contact: HR Specialist Lilli Sarasvirta, lilli.sarasvirta@tuni.fi
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Tampereen yliopisto ja Tampereen ammattikorkeakoulu muodostavat yhdessä Suomen toiseksi suurimman monitieteisen, innostavan ja vaikuttavan tutkimus- ja oppimisyhteisön. Korkeakouluyhteisömme osaamiskärjet ovat tekniikka, terveys ja yhteiskunta. Lue lisää: www.tuni.fi
Tampereen yliopiston lääketieteen ja terveysteknologian tiedekunnan alla toimivassa hemato-onkologisessa (HemoRes) -tutkimusryhmässä on haettavana tutkijatohtorin määräaikainen tehtävä translationaalisen leukemiatutkimuksen alalta.
Lääketieteen ja terveysteknologian tiedekuntamme on monialainen biolääketieteen tekniikan, bioteknologian, lääketieteen ja terveysteknologian tutkimuksen ja opetuksen korkeatasoinen yksikkö. Teemme kansainvälisesti merkittävää perus- ja soveltavaa tutkimusta.
Lue tarkemmat tiedot tehtävästä ja hakuohjeet yllä olevasta englanninkielisestä ilmoituksesta. Jätäthän hakemuksesi yliopiston sähköisellä hakulomakkeella (linkki löytyy tämän ilmoituksen alta). Hakuaika tehtävään päättyy 4.11.2024 klo 23.59.