Ajankohtaista

Molecular Modelling Mage – Orion

15.7.2021 | Avoimet työpaikat

https://www.orion.fi/en/careers/open-vacancies?rmpage=job&rmjob=1138&rmlang=UK

Orion Corporation operates in more than 20 countries, where we Orionees, 3200 in total, work in all kinds of positions. Among us there are Research Scientists, Laboratory Technicians, Engineers and IT Specialists as well as people working in Production, just to mention some examples. We offer diverse and responsible jobs to our personnel in a truly multi-disciplinary work environment. We encourage people to develop their competences and offer opportunities to affect the job description and creating their own career path at Orion. We are searching for top talents who are ready to share our passion for the work that we do.

Orion is seeking a Molecular Modelling Mage (an experienced Senior Scientist) to further develop  our capabilities and push the boundaries of theoretical drug discovery research carried out in Computational Medicine Design (CMD) unit.

Description of position

The Molecular Modelling Mage will work in the drug discovery projects linking and interfacing with biology and chemistry with both ab initio and data-driven perspectives. For this, it is critical to constantly rediscover the best suitable strategy for each project and define how to increase the target understanding and how to navigate the path of multiparameter optimization in modality design. For example, approaches can be both ligand- and structure-based virtual screening and design, protein modelling, physics-based simulations, structure-activity data analysis, machine learning and utilization of variety of in-house and public data sources. The Molecular Modelling Mage will collaborate closely with a broad range of scientists including other modellers in the CMD unit, medicinal chemists, pharmacologists and biologists.

The position is full-time and you will be based in Espoo or Turku, Finland.

Description of unit

Orion is a globally operating Finnish company listed on the Helsinki Stock Exchange. Orion develops, manufactures and markets human and veterinary pharmaceuticals, active pharmaceutical ingredients and diagnostic tests for global markets. Orion’s pharmaceutical innovations are created within its R&D organization, including e.g. non-clinical research, clinical development, formulation development and medical affairs. The organization employs top professionals in the field of drug molecule development and optimization.

Medicine Design contributes to the drug discovery process of Orion R&D from target validation all the way to the candidate nomination. We are responsible for translating new drug targets to therapeutical modalities together with other line functions. Our scientists in biology, chemistry and computer-aided medicine design are key players in the multiple research programs driven by Orion’s therapy areas of Neurological Disorders and Oncology. We also support our colleagues around R&D with our core competences.

Requirements

To be a successful Molecular Modelling Mage, you should have the following educational and professional work experiences:

  • Ph.D. from a suitable field, e.g. computational chemistry, bioorganic chemistry, biophysics, computer science or biochemistry
  • Concrete post-doctoral or industrial experience (above five years)
  • Broad experience in computational drug design, mastery of state-of-the-art ligand- and structure-based methods and their applications for medicine design
  • Solid understanding of fields relevant in the discovery process (e.g. medicinal chemistry, pharmacology, biochemistry, cell biology, structural biology, biophysics)

In addition, in depth experience in at least one of the following aspects:

  • Application of large-scale modern data science, machine learning and cheminformatics for drug discovery
  • Large-scale molecular dynamics simulations (e.g., relative and absolute free energy methods) for protein-ligand complexes
  • Track record of progressing modalities from hit identification through lead to clinical candidate

Experience with commercial molecular modelling software platforms, data pipelining tools (e.g. Knime) and programming/scripting/data analysis/data visualization (e.g. Python) is desirable.

We expect from all scientists the ability to work both independently and in multidisciplinary teams consisting of in-house scientists and external collaborators. A demonstrated record of research productivity and excellent oral and written communication skills in English are expected.

We offer

We offer you great, highly professional & experienced colleagues and the opportunity to show your talent and challenge yourself with interesting tasks in a modern multidisciplinary environment. Computational methods play a key role in Orion drug discovery so this is an opportunity to contribute to helping patients in need. Generous health and welfare benefits are available, as well as support for international relocation. Read more about R&D’s pipeline from here. 

Additional information

Is this the position you have been waiting for? Please send your cover letter and CV by 8th August 2021 and let us know what inspires you! Our application period is extended due to holiday period in Finland.

For additional information on the position, please contact Heikki Käsnänen, Head of Computational Medicine Design, +358104265279, during the following times: July 8th and 9th: 11 AM to 2 PM (EEST).

#LI-ORION

Approved medical examination which also includes drug testing is required prior to the employment. We will also carry out a security clearance prior to the employment for the selected person.