16.12.2022 | Avoimet työpaikat
Apply here!
The University of Helsinki is one of the world’s leading universities for multidisciplinary research. HiLIFE Helsinki Institute of Life Science is a research institute that supports high quality life science research across the University campuses and faculties. The research activities at the Institute of Biotechnology consist of several research teams focusing on a specific area of molecular biology, cell biology or biotechnology. For more information, please visit https://www.helsinki.fi/en/hilife-institute-of-biotechnology.
TEMPADAPT (Single-molecule visualization of temperature adaptation in sub-cellular dynamics and organization across bacteria) is a 5-year ERC-funded project in the laboratory of Jarno Mäkelä at the Institute of Biotechnology, from 2023 onwards. The project will aim at understanding temperature adaptation at the single molecule level in live bacteria. We will study bacteria thriving at 0°C (psychrophiles), moderate temperatures (mesophiles), and high temperatures up to 100°C (thermophiles). In addition to state-of-the-art super-resolution microscopy, the project will apply single-cell perturbations, machine learning and modelling to analyze, integrate, and make sense of single-cell and molecule level data.
The HiLIFE – Institute of Biotechnology, Mäkelä laboratory of Temperature Adaptation in Bacteria, invites applications for a position of
A Doctoral Researcher in Super-Resolution Microscopy and Microbiology
starting from January 2023, or as agreed. The PhD researcher will be offered up to 4-year fully funded contract.
Position description
We are looking for an enthusiastic and motivated doctoral researcher, who is interested in super-resolution microscopy and single-particle tracking, to join our research group for an ERC-funded project. The project involves planning and executing experimental work including state-of-the-art microscopy, genetic engineering, RNA-sequencing, data analysis, machine learning, and modelling to unravel how bacteria adapt to different temperatures. Our team will work on multiple topics at the interface of physics, chemistry, and biology: intracellular spatial organization, macromolecular crowding, liquid-liquid phase separation, heat- and cold shock protein dynamics, and gene regulation.
The appointee is expected to work full time on the Ph.D. thesis and to complete the thesis and the associated studies in four years. The successful applicant will apply to be a Ph.D. student in the appropriate Faculty. The Ph.D. degree consists of the student’s research project resulting in peer-reviewed publications, studies specific to the research field, as well as transferable skills training.
Selection criteria
A successful candidate will have a MSc or equivalent in biology, biophysics, computational biology, or other relevant fields, and has demonstrated a keen interest in quantitative approaches. Previous experience in ‘wet’ lab work, genetic engineering, microbiology, fluorescence microscopy, Python/R/Matlab coding, bioinformatics, or data analysis is considered an advantage. Excellent communication and writing skills in English and ability to work both independently and collaboratively as part of a multidisciplinary international team are expected. The candidate should have outstanding organization and time management skills.
Salary and benefits
The starting salary of the doctoral researcher will be 2400-2600 euros/month, depending on the appointees’ qualifications and experience. A trial period of 6 months will be applied. The University of Helsinki offers comprehensive services to its employees, including occupational health care, support in access to high quality sports facilities, and vast opportunities for professional development.
How to apply
Please submit your application as a single pdf file, which includes the following documents in English:
• A motivation letter including a description of your research interests (max 1 page)
• CV (max 2 pages) including a list of publications
Include also contact information of two persons who are willing to provide a reference letter by separate request. Please submit your application, together with the required attachment, through the University of Helsinki electronic recruitment system by clicking on the ‘Apply for job’ button. Internal applicants (i.e., current employees of the University of Helsinki) submit their applications through the SAP Fiori portal.
The deadline for the applications is 22nd of December, but the position will be filled once a suitable candidate has been identified.
For more information, please contact the Principal Investigator Jarno Mäkelä (jarno.p.makela(at)helsinki.fi) or visit our lab website.
Why work with us?
Finland is a member of the EU, has high quality free schooling (also in English), generous family benefits and healthcare, and was recently ranked as the best country in the world for expat families and in the world’s top ten most livable cities. Finland and the Helsinki region possess top expertise in sciences in terms of a vibrant talent pool, leading research, strong support services and functioning collaboration networks. For more information about working at the University of Helsinki and living in Finland, please see helsinki.fi/en/university/working-at-the-university
Helsinki Institute of Life Science
Helsinki Institute of Life Science (HiLIFE) is a new institute established in 2017 that supports high quality life science research across the University campuses and faculties. HiLIFE builds on existing strengths and new recruits and partnerships to create an attractive international environment for researchers to solve grand challenges in health, food, and environment. HiLIFE coordinates research infrastructures in life sciences and provides research-based interdisciplinary training.
University of Helsinki
The University of Helsinki (UH), founded in 1640, is a vibrant scientific community of 40,000 students and researchers. It is one of the leading multidisciplinary research universities and ranks among the top 100 international universities in the world. It is currently investing heavily in life sciences research. UH offers comprehensive services to its employees, including occupational health care and health insurance, sports facilities, and opportunities for professional development.
1.4.2022 | Koulutukset / seminaarit
SSB:n järjestämiä seminaareja odotellessa voi virittäytyä tunnelmaan seuraavilla luennoilla ja tapahtumilla. Tässä muutamia poimintoja takataskuun laitettavaksi.
Nuoret tutkijat / UTU
Milloin: 4. – 8.4.2022
Missä: PharmaCity & BioCity, Turun yliopisto
Mitä: Turun yliopiston bioteknologian laitoksen opiskelijaseminaari, jossa maisteri- ja diplomi-insinööriopiskelijat esittelevät lopputöidensä tuloksia suullisin esitelmin ja posterein.
https://www.utu.fi/en/news/events/nuoret-tutkijat
HiLIFE webinaarit
Milloin: Maanantaisin 30.5.2022 asti
Missä: Zoomissa (linkki joka webinaariin löytyy alla olevasta osoitteesta)
Mitä: Tutkijoiden pitämiä luentoja tutkimusaiheistaan.
https://www2.helsinki.fi/en/conferences/hilife-life-science-seminars/hilife-webinars
Frontiers of Science / UTU
Milloin: Torstaisin 12.5.2022 asti sekä jatkuen syksyllä 6.10.2022 lähtien.
Missä: Zoomissa / BioCity, Turun yliopisto
Mitä: Huippututkijoiden pitämiä seminaariesityksiä tutkimusaiheistaan.
https://biocityturku.fi/biocityevents/frontiers-of-science-seminars/
ChemBio 2022
Milloin: 8.-9.6.2022
Missä: Helsingin Messukeskuksessa
Mitä: Laboratoriodiagnostiikkaa, biopankkitutkimusta, tulevaisuuden lääkkeet, yritysesittelyjä…
https://chembio.messukeskus.com/
9.8.2021 | Avoimet työpaikat
https://www2.helsinki.fi/fi/avoimet-tyopaikat/postdoctoral-researcher-in-protein-biochemistry-and-structural-biology
The laboratory of Dr. Tommi Kajander at the Institute of Biotechnology, HiLIFE, University of Helsinki, Finland, is inviting applications for post-doctoral researcher in the area of protein biochemistry and structural biology in a joint project with Prof. Mart Saarma’s laboratory. We are seeking for dedicated and enthusiastic scientist to work on the structure and function of novel endoplasmic reticulum effector protein-receptor interactions in ER stress response regulation. Main targets are CDNF and MANF proteins and their interaction complexes in the ER.
The Institute of Biotechnology is a research institute at University of Helsinki, located in the Viikki science park. The institute harbors ~35 research groups and 250 researchers, and it operates at the highest international level. For more information on the Institute, please visit https://www.helsinki.fi/en/hilife-institute-of-biotechnology.
The institute has excellent infrastructure for structural biology (X-ray, CryoEM, NMR) including the crystallography core facility run by the PI.
The post-doctoral applicants should hold PhD in biochemistry or a related field. Strong experience in protein biochemistry including cloning and mutagenesis and protein expression and purification, from various hosts and good communication skills in English are required. Knowledge and experience in structural biology and molecular biophysics techiques and cell culture is beneficial. This is an opportunity to work on high impact targets and obtain in depth technical skills in the research area. The position will provide excellent opportunities for collaborations, as this is a joint project in close collaboration with Prof. Mart Saarma’s group, with also potential international and national collaborations and visits to e.g. synchrotron sources in Europe (ESRF, DLS, MAXIV). An attitude to carry out ambitious research projects, good problem solving skills, goal-oriented mind-set and willingness to learn and apply new methodologies is highly appreciated. The working language of the laboratory is English; knowledge of Finnish is not a requirement.
The postdoctoral position is initially limited to 1 year, with a possibility of extension to three years. The salaries will be based on the University salary scheme (level 5) for teaching and research personnel composed of both task specific and personal performance component The position is available immediately or as agreed.
Application should include the following documents as a single pdf file (max 5 pages): CV (max 2 pages), list of publications, motivation letter (max 1 page) including a description of your research interests, and the names and contact details of at least two referees. Please submit your application, together with the required pdf attachment, through the University of Helsinki electronic recruitment system by clicking on the ‘Apply for job’ button. Internal applicants (i.e., current employees of the University of Helsinki) should submit their applications through the SAP HR portal. For technical support regarding the recruitment system, please contact ‘rekrytointi@helsinki.fi’.
The deadline for the applications is 31st of August, 2021, or until suitable candidate have been found.
For informal inquiries, contact ‘tommi.kajander(at)helsinki.fi’
See also:
https://www2.helsinki.fi/en/researchgroups/structural-biology-of-protein…
https://www2.helsinki.fi/en/researchgroups/neurotrophic-factors-and-rege…
For technical support regarding the recruitment system, please contact rekrytointi@helsinki.fi.
Selected recent references related to project and the laboratory:
Kovaleva V, Yu LY, Ivanova L, Nam J, Eesmaa A, Kumpula EP, Huiskonen J, Lindholm P, Voutilainen M, Karelson M, Saarma M. MANF regulates unfolded protein response and neuronal survival through its ER-located receptor IRE1α bioRxiv 2020.09.22.307744
Eesmaa A, Yu LY, Göös H, Nõges K, Kovaleva V, Hellman M, Zimmermann R, Jung M, Permi P, Varjosalo M, Lindholm P, Saarma M. The cytoprotective protein MANF promotes neuronal survival independently from its role as a GRP78 cofactor. J Biol Chem. 2021 Jan 15;296:100295.
Lindahl M, Saarma M, Lindholm P. Unconventional neurotrophic factors CDNF and MANF: Structure, physiological functions and therapeutic potential. Neurobiol Dis. 2017 Jan;97(Pt B):90-102.
14.6.2021 | Avoimet työpaikat
https://www2.helsinki.fi/fi/avoimet-tyopaikat/post-doctoral-researchers-andor-phd-students-in-cell-biology-and-stem-cell-biology
The HiLIFE – Institute of Biotechnology (BI), located in the Viikki science park, is a research institute at University of Helsinki. The institute harbors ~35 research groups and 250 researchers, and it operates at the highest international level. For more information on the Institute, please visit https://www.helsinki.fi/en/hilife-institute-of-biotechnology.
The laboratory of Dr. Jette Lengefeld is inviting applications for post-doctoral researchers and/or PhD-students in cell biology and stem cell biology.
The failure to regenerate tissue with age is a major health issue. A contributor to this decline is the loss of stem cell function. Despite the essential role of stem cells, it is still unclear how they fail to maintain their functions during ageing and disease. We discovered a new aspect of stem cell ageing in vivo: cellular enlargement. With age and damage, stem cells increase in size causing their functional decline. However, we are only beginning to understand how size impacts stem cell fitness and the physiological importance of this process remains unsolved.
The Lengefeld research group uses blood (hematopoietic) stem cells from mice and human bone marrow donations to address these fascinating questions:
- What pathways cause stem cell dysfunction during their enlargement?
We use blood (hematopoietic) stem cells of mouse models to identify the molecular mechanisms impairing fitness of large stem cells from a metabolic perspective. - Can we rejuvenate stem cells after aging and damage?
We explore approaches to rejuvenate stem cells and investigate the effects on cellular ageing and organismal health. - Does deregulation of size lead to cancer?
We utilize blood stem cells from mice and humans to identify factors that facilitate leukaemia in vivo and to investigate the underlying mechanisms.
The post-doctoral applicants should hold PhD in cell biology, stem cell biology, cell size regulation or a related field. Strong expertise in stem cell biology and experience working with mice is highly beneficial. The PhD-student applicants should obtain MSc or related degree in the biology field latest by August 2022, and have a strong interest to carry out cutting-edge research. The positions will provide multiple opportunities for collaborations with potential lab visits abroad. An attitude to drive own research and work in an intra and inter team fashion is highly appreciated. In return, the candidates are offered an access to a wide variety of methodologies and advanced techniques. The working language of the laboratory, the BI and HiLIFE is English and good communication skills in English are required.
The postdoctoral researcher and PhD-student positions are initially limited to 2 and 4 years, respectively, with a possibility of extension. A trial period of 6 months will be applied, and the salaries will be based on the University salary scheme for teaching and research personnel composed of both task specific and personal performance components.
Application should include the following documents as a single pdf file: CV, list of publications, motivation letter including a description of your research interests, and the names and telephone numbers of at least two referees.
Please submit your application, together with the required attachments, through the University of Helsinki electronic recruitment system by clicking the “Apply for the position” – link below. Applicants employed by the University of Helsinki must submit their application through the SAP HR portal.
The deadline for the applications is 8th of July 2021, but the positions will be filled immediately once suitable candidates have been identified.
For informal inquiries, contact ‘jette.lengefeld(at)helsinki.fi’, and for more information about our research, please visit https://www2.helsinki.fi/en/hilife-institute-of-biotechnology/research/c…
For technical support regarding the recruitment system, please contact rekrytointi@helsinki.fi.
27.3.2021 | Avoimet työpaikat
https://www2.helsinki.fi/fi/avoimet-tyopaikat/tutkimusteknikko-laboratoriokoordinaattori-laboratorioinsinoori
Biotekniikan instituutti (BI) on Helsingin yliopiston biotieteiden instituutin HiLIFE: n operatiivinen yksikkö. BI:n tehtävänä on edistää biotieteiden perustutkimusta ihmisten ja ympäristön hyödyksi. Huippututkimuksen lisäksi BI ylläpitää korkealaatuisia tutkimusinfrastruktuureja.
Helsingin yliopiston Biotekniikan Instituutin Proteomiikka yksikkö (Proteomics Unit) (https://www2.helsinki.fi/en/infrastructures/protein-proteome-network-hel…) hakee TUTKIMUSTEKNIKKOA / LABORATORIOKOORDINAATTORIA / LABORATORIOINSINÖÖRIÄ määräaikaiseen työsuhteeseen 1.5.2021 – 31.12.2023 (aloituspäivämäärä neuvoteltavissa).
Tutkimusryhmä hakee tutkimusteknikkoa/laboratoriokoordinaattoria/laboratorioinsinööriä avustamaan eri molekyylibiologian, biokemian ja proteomiikan tehtävissä sekä osallistumaan massaspektrometrian laitteistojen ylläpitoon, käyttöön ja menetelmien kehittämiseen. Lisäksi työtehtäviin kuuluu yleisiä laboratorion ylläpitotehtäviä. Työ on monipuolista ja tarjoaa oman osaamisen kehittämistä.
Tehtävään valittavalta henkilöltä toivomme kokemusta joissakin yllä mainituista osa-alueista. Lisäksi hänen tulee olla innostunut oppimaan uutta. Hakijalla tulee olla kykyä oma-aloitteiseen ja itsenäiseen työskentelyyn sekä hyvät organisointi- ja tiimityöskentelytaidot. Työ vaatii vuorovaikutustaitoja mm. ohjaus- ja opastustilanteissa, sekä hintaneuvotteluissa yritysten edustajien kanssa. Yksikön toiminta on kansainvälistä, joten edellytämme hyvää englannin kielen taitoa.
Soveltuvia tutkintoja tehtävän täyttöön ovat esimerkiksi laboratorioalan perustutkinto, insinöörin- tai maisterintutkinto. Tehtävän palkkaus perustuu yliopistojen palkkausjärjestelmän muun henkilöstön vaativuustasokartan tasoihin 6-9, riippuen henkilön koulutuksesta ja työkokemuksesta. Lisäksi maksetaan henkilökohtaiseen suoriutumiseen perustuva palkanosa. Tehtävässä on kuuden kuukauden koeaika.
Hakijoita pyydetään toimittamaan hakemuksensa yhtenä pdf-tiedostona, joka sisältää seuraavat liitteet:
– CV (sisältäen ainakin kahden suosittelijan yhteistiedot),
– motivaatiokirje (max. 1 sivu).
Hakemus liitteineen jätetään Helsingin yliopiston sähköiseen rekrytointijärjestelmään Hae työpaikkaa -linkistä. Helsingin yliopistoon työsuhteessa olevat sisäiset hakijat jättävät hakemuksensa SAP HR -portaalin kautta. Hakuaika päättyy 9.4.2021.
Lisätietoja antaa tutkimusjohtaja Markku Varjosalo, markku.varjosalo(at)helsinki.fi.