Ajankohtaista

Post­doc­to­ral Re­searc­her in Pro­tein Bioc­he­mi­stry and Struc­tu­ral Bio­lo­gy

9.8.2021 | Avoimet työpaikat

https://www2.helsinki.fi/fi/avoimet-tyopaikat/postdoctoral-researcher-in-protein-biochemistry-and-structural-biology

The laboratory of Dr. Tommi Kajander at the Institute of Biotechnology, HiLIFE, University of Helsinki, Finland, is inviting applications for post-doctoral researcher in the area of protein biochemistry and structural biology in a joint project with Prof. Mart Saarma’s laboratory. We are seeking for dedicated and enthusiastic scientist to work on the structure and function of novel endoplasmic reticulum effector protein-receptor interactions in ER stress response regulation. Main targets are CDNF and MANF proteins and their interaction complexes in the ER.

The Institute of Biotechnology is a research institute at University of Helsinki, located in the Viikki science park. The institute harbors ~35 research groups and 250 researchers, and it operates at the highest international level. For more information on the Institute, please visit https://www.helsinki.fi/en/hilife-institute-of-biotechnology.
The institute has excellent infrastructure for structural biology (X-ray, CryoEM, NMR) including the crystallography core facility run by the PI.

The post-doctoral applicants should hold PhD in biochemistry or a related field. Strong experience in protein biochemistry including cloning and mutagenesis and protein expression and purification, from various hosts and good communication skills in English are required. Knowledge and experience in structural biology and molecular biophysics techiques and cell culture is beneficial. This is an opportunity to work on high impact targets and obtain in depth technical skills in the research area. The position will provide excellent opportunities for collaborations, as this is a joint project in close collaboration with Prof. Mart Saarma’s group, with also potential international and national collaborations and visits to e.g. synchrotron sources in Europe (ESRF, DLS, MAXIV). An attitude to carry out ambitious research projects, good problem solving skills, goal-oriented mind-set and willingness to learn and apply new methodologies is highly appreciated. The working language of the laboratory is English; knowledge of Finnish is not a requirement.

The postdoctoral position is initially limited to 1 year, with a possibility of extension to three years. The salaries will be based on the University salary scheme (level 5) for teaching and research personnel composed of both task specific and personal performance component The position is available immediately or as agreed.

Application should include the following documents as a single pdf file (max 5 pages): CV (max 2 pages), list of publications, motivation letter (max 1 page) including a description of your research interests, and the names and contact details of at least two referees. Please submit your application, together with the required pdf attachment, through the University of Helsinki electronic recruitment system by clicking on the ‘Apply for job’ button. Internal applicants (i.e., current employees of the University of Helsinki) should submit their applications through the SAP HR portal. For technical support regarding the recruitment system, please contact ‘rekrytointi@helsinki.fi’.

The deadline for the applications is 31st of August, 2021, or until suitable candidate have been found.

For informal inquiries, contact ‘tommi.kajander(at)helsinki.fi’
See also:
https://www2.helsinki.fi/en/researchgroups/structural-biology-of-protein…
https://www2.helsinki.fi/en/researchgroups/neurotrophic-factors-and-rege…

For technical support regarding the recruitment system, please contact rekrytointi@helsinki.fi.

Selected recent references related to project and the laboratory:
Kovaleva V, Yu LY, Ivanova L, Nam J, Eesmaa A, Kumpula EP, Huiskonen J, Lindholm P, Voutilainen M, Karelson M, Saarma M. MANF regulates unfolded protein response and neuronal survival through its ER-located receptor IRE1α bioRxiv 2020.09.22.307744

Eesmaa A, Yu LY, Göös H, Nõges K, Kovaleva V, Hellman M, Zimmermann R, Jung M, Permi P, Varjosalo M, Lindholm P, Saarma M. The cytoprotective protein MANF promotes neuronal survival independently from its role as a GRP78 cofactor. J Biol Chem. 2021 Jan 15;296:100295.

Lindahl M, Saarma M, Lindholm P. Unconventional neurotrophic factors CDNF and MANF: Structure, physiological functions and therapeutic potential. Neurobiol Dis. 2017 Jan;97(Pt B):90-102.

Post-doc­to­ral re­searc­hers and/​or PhD-stu­dents in cell bio­lo­gy and stem cell bio­lo­gy

14.6.2021 | Avoimet työpaikat

https://www2.helsinki.fi/fi/avoimet-tyopaikat/post-doctoral-researchers-andor-phd-students-in-cell-biology-and-stem-cell-biology

The HiLIFE – Institute of Biotechnology (BI), located in the Viikki science park, is a research institute at University of Helsinki. The institute harbors ~35 research groups and 250 researchers, and it operates at the highest international level. For more information on the Institute, please visit https://www.helsinki.fi/en/hilife-institute-of-biotechnology.

The laboratory of Dr. Jette Lengefeld is inviting applications for post-doctoral researchers and/or PhD-students in cell biology and stem cell biology.

The failure to regenerate tissue with age is a major health issue. A contributor to this decline is the loss of stem cell function. Despite the essential role of stem cells, it is still unclear how they fail to maintain their functions during ageing and disease. We discovered a new aspect of stem cell ageing in vivo: cellular enlargement. With age and damage, stem cells increase in size causing their functional decline. However, we are only beginning to understand how size impacts stem cell fitness and the physiological importance of this process remains unsolved.

The Lengefeld research group uses blood (hematopoietic) stem cells from mice and human bone marrow donations to address these fascinating questions:

  • What pathways cause stem cell dysfunction during their enlargement?
    We use blood (hematopoietic) stem cells of mouse models to identify the molecular mechanisms impairing fitness of large stem cells from a metabolic perspective.
  • Can we rejuvenate stem cells after aging and damage?
    We explore approaches to rejuvenate stem cells and investigate the effects on cellular ageing and organismal health.
  • Does deregulation of size lead to cancer?
    We utilize blood stem cells from mice and humans to identify factors that facilitate leukaemia in vivo and to investigate the underlying mechanisms.

The post-doctoral applicants should hold PhD in cell biology, stem cell biology, cell size regulation or a related field. Strong expertise in stem cell biology and experience working with mice is highly beneficial. The PhD-student applicants should obtain MSc or related degree in the biology field latest by August 2022, and have a strong interest to carry out cutting-edge research. The positions will provide multiple opportunities for collaborations with potential lab visits abroad. An attitude to drive own research and work in an intra and inter team fashion is highly appreciated. In return, the candidates are offered an access to a wide variety of methodologies and advanced techniques. The working language of the laboratory, the BI and HiLIFE is English and good communication skills in English are required.

The postdoctoral researcher and PhD-student positions are initially limited to 2 and 4 years, respectively, with a possibility of extension. A trial period of 6 months will be applied, and the salaries will be based on the University salary scheme for teaching and research personnel composed of both task specific and personal performance components.

Application should include the following documents as a single pdf file: CV, list of publications, motivation letter including a description of your research interests, and the names and telephone numbers of at least two referees.

Please submit your application, together with the required attachments, through the University of Helsinki electronic recruitment system by clicking the “Apply for the position” – link below. Applicants employed by the University of Helsinki must submit their application through the SAP HR portal.

The deadline for the applications is 8th of July 2021, but the positions will be filled immediately once suitable candidates have been identified.

For informal inquiries, contact ‘jette.lengefeld(at)helsinki.fi’, and for more information about our research, please visit https://www2.helsinki.fi/en/hilife-institute-of-biotechnology/research/c…

For technical support regarding the recruitment system, please contact rekrytointi@helsinki.fi.

Tut­ki­mus­tek­nik­ko / La­bo­ra­to­rio­koor­di­naat­to­ri /La­bo­ra­to­rioin­si­nöö­ri

27.3.2021 | Avoimet työpaikat

https://www2.helsinki.fi/fi/avoimet-tyopaikat/tutkimusteknikko-laboratoriokoordinaattori-laboratorioinsinoori

Biotekniikan instituutti (BI) on Helsingin yliopiston biotieteiden instituutin HiLIFE: n operatiivinen yksikkö. BI:n tehtävänä on edistää biotieteiden perustutkimusta ihmisten ja ympäristön hyödyksi. Huippututkimuksen lisäksi BI ylläpitää korkealaatuisia tutkimusinfrastruktuureja.

Helsingin yliopiston Biotekniikan Instituutin Proteomiikka yksikkö (Proteomics Unit) (https://www2.helsinki.fi/en/infrastructures/protein-proteome-network-hel…) hakee TUTKIMUSTEKNIKKOA / LABORATORIOKOORDINAATTORIA / LABORATORIOINSINÖÖRIÄ määräaikaiseen työsuhteeseen 1.5.2021 – 31.12.2023 (aloituspäivämäärä neuvoteltavissa).

Tutkimusryhmä hakee tutkimusteknikkoa/laboratoriokoordinaattoria/laboratorioinsinööriä avustamaan eri molekyylibiologian, biokemian ja proteomiikan tehtävissä sekä osallistumaan massaspektrometrian laitteistojen ylläpitoon, käyttöön ja menetelmien kehittämiseen. Lisäksi työtehtäviin kuuluu yleisiä laboratorion ylläpitotehtäviä. Työ on monipuolista ja tarjoaa oman osaamisen kehittämistä.

Tehtävään valittavalta henkilöltä toivomme kokemusta joissakin yllä mainituista osa-alueista. Lisäksi hänen tulee olla innostunut oppimaan uutta. Hakijalla tulee olla kykyä oma-aloitteiseen ja itsenäiseen työskentelyyn sekä hyvät organisointi- ja tiimityöskentelytaidot. Työ vaatii vuorovaikutustaitoja mm. ohjaus- ja opastustilanteissa, sekä hintaneuvotteluissa yritysten edustajien kanssa. Yksikön toiminta on kansainvälistä, joten edellytämme hyvää englannin kielen taitoa.

Soveltuvia tutkintoja tehtävän täyttöön ovat esimerkiksi laboratorioalan perustutkinto, insinöörin- tai maisterintutkinto. Tehtävän palkkaus perustuu yliopistojen palkkausjärjestelmän muun henkilöstön vaativuustasokartan tasoihin 6-9, riippuen henkilön koulutuksesta ja työkokemuksesta. Lisäksi maksetaan henkilökohtaiseen suoriutumiseen perustuva palkanosa. Tehtävässä on kuuden kuukauden koeaika.
Hakijoita pyydetään toimittamaan hakemuksensa yhtenä pdf-tiedostona, joka sisältää seuraavat liitteet:
– CV (sisältäen ainakin kahden suosittelijan yhteistiedot),
– motivaatiokirje (max. 1 sivu).

Hakemus liitteineen jätetään Helsingin yliopiston sähköiseen rekrytointijärjestelmään Hae työpaikkaa -linkistä. Helsingin yliopistoon työsuhteessa olevat sisäiset hakijat jättävät hakemuksensa SAP HR -portaalin kautta. Hakuaika päättyy 9.4.2021.

Lisätietoja antaa tutkimusjohtaja Markku Varjosalo, markku.varjosalo(at)helsinki.fi.