Orion’s Immuno-Oncology (IO) research team is looking to recruit an enthusiastic and motivated in-vivo Research Scientist/Senior Scientist to join the IO team on permanent basis in Turku, Finland.
Description of position
In this role you will contribute to the in-vivo studies and unit’s technical excellence. You will be responsible for supporting IO drug discovery projects and ensuring the highest standard of testing environment. In this role you will have an unique opportunity to work with a range of treatment modalities ranging from small molecules to biologics such as bispecific antibodies and CAR-T cells. In addition, you will also participate in supporting other in-vivo studies performed within the Oncology Research department.
- Complying with the local Animals (Scientific Procedures) Act and the associated Codes of Practice for the Housing and Care of the Animals used in Scientific Procedures.
- Design, setup and implement IO tumor models in conjunction with internal project teams and in line with the regulations.
- Establish and run in-vivo efficacy, PK/PD and mechanism of action studies to test novel IO and other oncology drugs in tumor and non-tumor bearing rodents.
- Establish and validate human and mouse ex vivo primary immune cells assays to study the mechanism of action of IO drugs.
- Provide immunology expertise for the project teams and act as an in-vivo project lead within the IO team.
- Co-ordinate with the line-manager and project team to ensure timely delivery of data and provide reports and presentations as required.
- Provide expert knowledge of tumor immunology, cancer Immunotherapy and tumor biology to the project team.
- Maintaining high quality and accurate records in accordance with the appropriate regulatory standards.
- Working in close collaboration with in-vitro scientists, in-vivo technicians and animal welfare unit.
- Supporting in-vivo needs across the Oncology research organization where necessary
Description of Unit
Immuno-Oncology (IO) is one of four Research teams in Orion’s Oncology R&D. IO team is accountable for novel drug discovery projects, identification and validation of potential IO drug targets within state-of-the-art laboratories and technologies.
We offer you the opportunity to show your talent in one of the most innovative companies in Finland. You get a chance to work in a challenging field of work with excellent colleagues. You will also have the chance to do meaningful work and build the future of Orion. We are striving for excellence in everything we do. We succeed, learn together and appreciate each other. You’ll be empowered to deliver value. Read more about our values!
To be a successful in-vivo Research Scientist/Senior Scientist ideally you should have the following educational and professional work experiences:
- PhD degree in Immunology, cancer biology or Immuno-Oncology with 3+ years of Industry or academic experience.
- Strong understanding of Immuno-Oncology, cancer immunotherapy, immune cell signalling as evidenced by high impact journal publications or poster presentation at IO conferences.
- Previous experience with bispecific antibodies and CAR-T cells is a plus.
- Strong in-vivo research experience especially using mouse syngeneic, humanised mouse tumor models and xenograft tumor models
- Demonstrate ability to independently design, conduct and interpret the data from in-vivo mouse tumor studies.
- Proven experience using standard immunology techniques to support in-vivo and ex-vivo analysis.
- Demonstrate proficiency in performing tissues harvest and processing samples for multi-colour flow cytometry, multiplex ELISA, IHC, single cell RNA sequencing and gene expression analysis.
- Sound technical competence that includes rodent handling, injections (IV, IP, SC, and PO), palpation, bleeding, and tissue harvest and ex-vivo analysis methods.
- Competency in using GraphPad Prism, flowjo, nSolver software and other standard office software.
- Excellent attention to details with strong communication skills.
- Flexibility and willingness to learn new techniques and take additional responsibilities as a member of the research team.
Please send your application with a latest CV, cover letter and salary request in English by 31st August 2022 at the latest. We may start interviewing candidates before application period closes.
For further information, please contact Dr Anil Thotakura, Head of Immuno-oncology, +358 50 966 7229, during the following times: July 29th from 3.00 to 5.00 pm, August 4th, 19th & 26th from 3.00 to 5.00 pm.