Ajankohtaista

Molecular Modelling Mage – Orion

15.7.2021 | Avoimet työpaikat

https://www.orion.fi/en/careers/open-vacancies?rmpage=job&rmjob=1138&rmlang=UK

Orion Corporation operates in more than 20 countries, where we Orionees, 3200 in total, work in all kinds of positions. Among us there are Research Scientists, Laboratory Technicians, Engineers and IT Specialists as well as people working in Production, just to mention some examples. We offer diverse and responsible jobs to our personnel in a truly multi-disciplinary work environment. We encourage people to develop their competences and offer opportunities to affect the job description and creating their own career path at Orion. We are searching for top talents who are ready to share our passion for the work that we do.

Orion is seeking a Molecular Modelling Mage (an experienced Senior Scientist) to further develop  our capabilities and push the boundaries of theoretical drug discovery research carried out in Computational Medicine Design (CMD) unit.

Description of position

The Molecular Modelling Mage will work in the drug discovery projects linking and interfacing with biology and chemistry with both ab initio and data-driven perspectives. For this, it is critical to constantly rediscover the best suitable strategy for each project and define how to increase the target understanding and how to navigate the path of multiparameter optimization in modality design. For example, approaches can be both ligand- and structure-based virtual screening and design, protein modelling, physics-based simulations, structure-activity data analysis, machine learning and utilization of variety of in-house and public data sources. The Molecular Modelling Mage will collaborate closely with a broad range of scientists including other modellers in the CMD unit, medicinal chemists, pharmacologists and biologists.

The position is full-time and you will be based in Espoo or Turku, Finland.

Description of unit

Orion is a globally operating Finnish company listed on the Helsinki Stock Exchange. Orion develops, manufactures and markets human and veterinary pharmaceuticals, active pharmaceutical ingredients and diagnostic tests for global markets. Orion’s pharmaceutical innovations are created within its R&D organization, including e.g. non-clinical research, clinical development, formulation development and medical affairs. The organization employs top professionals in the field of drug molecule development and optimization.

Medicine Design contributes to the drug discovery process of Orion R&D from target validation all the way to the candidate nomination. We are responsible for translating new drug targets to therapeutical modalities together with other line functions. Our scientists in biology, chemistry and computer-aided medicine design are key players in the multiple research programs driven by Orion’s therapy areas of Neurological Disorders and Oncology. We also support our colleagues around R&D with our core competences.

Requirements

To be a successful Molecular Modelling Mage, you should have the following educational and professional work experiences:

  • Ph.D. from a suitable field, e.g. computational chemistry, bioorganic chemistry, biophysics, computer science or biochemistry
  • Concrete post-doctoral or industrial experience (above five years)
  • Broad experience in computational drug design, mastery of state-of-the-art ligand- and structure-based methods and their applications for medicine design
  • Solid understanding of fields relevant in the discovery process (e.g. medicinal chemistry, pharmacology, biochemistry, cell biology, structural biology, biophysics)

In addition, in depth experience in at least one of the following aspects:

  • Application of large-scale modern data science, machine learning and cheminformatics for drug discovery
  • Large-scale molecular dynamics simulations (e.g., relative and absolute free energy methods) for protein-ligand complexes
  • Track record of progressing modalities from hit identification through lead to clinical candidate

Experience with commercial molecular modelling software platforms, data pipelining tools (e.g. Knime) and programming/scripting/data analysis/data visualization (e.g. Python) is desirable.

We expect from all scientists the ability to work both independently and in multidisciplinary teams consisting of in-house scientists and external collaborators. A demonstrated record of research productivity and excellent oral and written communication skills in English are expected.

We offer

We offer you great, highly professional & experienced colleagues and the opportunity to show your talent and challenge yourself with interesting tasks in a modern multidisciplinary environment. Computational methods play a key role in Orion drug discovery so this is an opportunity to contribute to helping patients in need. Generous health and welfare benefits are available, as well as support for international relocation. Read more about R&D’s pipeline from here. 

Additional information

Is this the position you have been waiting for? Please send your cover letter and CV by 8th August 2021 and let us know what inspires you! Our application period is extended due to holiday period in Finland.

For additional information on the position, please contact Heikki Käsnänen, Head of Computational Medicine Design, +358104265279, during the following times: July 8th and 9th: 11 AM to 2 PM (EEST).

#LI-ORION

Approved medical examination which also includes drug testing is required prior to the employment. We will also carry out a security clearance prior to the employment for the selected person.

Cell culture laboratory assistant

1.7.2021 | Ajankohtaista

https://www.orion.fi/en/careers/open-vacancies/

Orion Corporation operates in more than 20 countries, where we Orionees, 3200 in total, work in all kinds of positions. Among us there are Research Scientists, Laboratory Technicians, Engineers and IT Specialists as well as people working in Production, just to mention some examples. We offer diverse and responsible jobs to our personnel in a truly multi-disciplinary work environment. We encourage people to develop their competences and offer opportunities to affect the job description and creating their own career path at Orion. We are searching for top talents who are ready to share our passion for the work that we do.

We are seeking a laboratory research assistant to join the Protein & Antibody Engineering unit.

Description of position

As research assistant you will play an important role in the unit. You will be supporting our projects and working closely together with scientists and assistants both within our own unit and cross-functionally. Your tasks will span activities from protein production to characterization, but your main focus will be on cell culture work, developing and maintaining cell lines, and producing proteins. You will have good opportunities to learn new skills and develop your competences.

Key responsibilities:

  • Working closely together with the team and support projects with experimental work
  • Maintain cell cultures
  • Support protein production with transient transfection of mammalian and bacterial cells
  • Support the team and projects with experimental work withing protein purification and characterization
  • Contribute to our technology development projects
  • Developing and maintaining laboratory protocols

Desciption of Unit

Protein & Antibody Engineering is a newly established unit and an integrated part of the Medicine Design department, which is responsible for converting new drug targets into large and small biomolecule therapeutics. The unit is tasked with the discovery and antibody engineering incl. novel formats for the treatment of diseases in Orion’s focus areas Oncology and Neurological disorders. We are involved in the projects form the early ideas until delivery of the clinical candidate. The laboratory has a fully equipped protein production facility and a wide range of characterization technologies. Expanding our capabilities and building technologies is essential for us and we are constantly exploring new ideas and implementing new methods, platforms, and technologies. The unit is currently composed of 9 scientists, 1 assistant as well as a handful of students and post doc researchers working with various aspects of protein production and characterization.

We offer

The position offers an exciting and challenging opportunity for being part of a small team with a big responsibility in one of Finlands most innovative companies. You will be working with highly motivated people in pharmaceutical industry on versatile projects and be part of building our protein and antibody capabilities for the future of Orion. Constant development and appreciation of personnel are part of our core values and we can offer attractive career development opportunities. The culture of Orion R&D is informal and we enjoy working together.

We strive for excellence in everything we do. We succeed, learn together, and appreciate each other. You’ll be empowered to deliver value.  Please follow this link for Orion’s values.

Requirements

To succeed in this role you need to:

  • Have good hands-on experience working with cell cultures
  • Have experience working in a clean cell culture laboratory
  • Have hands-on experience working with protein samples
  • Be a motivated team player
  • Be motivated to learn and take on new challenges
  • Have a positive can-do attitude
  • Thrive well in an constantly changing environment

Additional information

Are you the person we are looking for? Please send your CV and application to us by July 5th at the latest.

For more information please contact Rune Salbo, Head of Protein & Antibody Engineering by phone +358 50 966 7718 via email rune.salbo@orionpharma.com.

Join us – together we build well-being and do work that we are proud of!

#LI-ORION

Approved medical examination which also includes drug testing is required prior to the employment.

Research Assistant/Associate (permanent position) Cancer Genomics, Oncology Research

13.5.2021 | Avoimet työpaikat

https://duunitori.fi/tyopaikat/tyo/orion-research-assistantassociate-permanent-position-cancer-genomics-oncology-research-turku-sdsuu-13198208?utm_source=loimu&utm_medium=site

Description of position

We are looking for an experienced Research Assistant/Associate to be based in the R&D laboratories in Turku. This is a hands-on position for an experienced Assistant/Associate who enjoys working in the lab. You will be part of the Cancer Genomics team, but work in close collaboration with the other research organisations of Orion. You will have an opportunity to be part of a highly motivated and international team and work in modern laboratory facilities equipped with state-of-art laboratory instrumentation. This is a permanent position and location is Turku, Finland.

Main responsibilities:

  • Provide research support for in vitro cell based assays, biochemical assays and molecular biology assays (such as qPCR, WB and/or cell imaging)
  • Independently maintain and perform studies with mammalian cell cultures
  • Determine the potency and mechanism of action of small molecule compounds
  • Be responsible for the accurate documentation of research and screening results
  • Maintain high standards of housekeeping and take responsibility of routine laboratory and cell culture maintenance tasks

Description of unit

Oncology Research is accountable for the discovery of novel targets and research projects in the therapy area of oncology at Orion. Cancer Genomics team is one of the four research teams in Oncology Research, and our teams build the R&D Oncology portfolio and Oncology strategy in close collaboration with business and all R&D global functions.

We Offer

We are offering an excellent opportunity to work in a dynamic team in modern laboratory facilities equipped with state-of-art laboratory instrument in Oncology Research at Orion. Join us – together we build well-being and do work that we are proud of!

In Orion, we have a highly interesting R&D pipeline and enthusiastic working environment. We offer an exciting opportunity to create an impact on the future therapies for patients. As an expert of your own field, you will be a member of multi-disciplinary team jointly innovating and developing new treatments for the patients. Appreciation of colleagues and continuous development are part of our core values. The culture of Orion R&D is informal and we enjoy working together.

Requirements

A successful applicant has several years of experience in hands-on laboratory work and techniques related to cellular and biochemical assays, for example in running high throughput screens as well as common molecular biology techniques (RNA/DNA/protein isolations and analysis, and/or immunoassays). Previous strong knowledge and experience working with mammalian cell cultures and related functional studies (for example transfections, reporter assays) is required.

Additionally, we expect that you have a suitable degree in the field of health sciences, for example from University of Applied Sciences. You are highly motivated, possess interpersonal and organizational skills that allow you to interact in a collaborative work environment. You also have basic computational skills, ideally experience in documentation using electronic lab notebook, and are able to communicate in verbal and written English. Industry experience is an advantage, but not a requirement.

Additional information

Please send your application latest by 26 May 2021.

For further information, please contact Dr Julia Lindqvist, Senior Scientist in Cancer Genomics and Metabolism, +358 50 966 7975, during the following hours: Wednesday May 19 at 15.00-16.00 or Friday May 21 at 9.00-10.00.

#LI-ORION

Approved medical examination which also includes drug testing is required prior to the employment. We will also carry out a security clearance prior to the employment for the selected person.

Research scientist, analytical development

11.5.2021 | Avoimet työpaikat

https://duunitori.fi/tyopaikat/tyo/orion-research-scientist-analytical-development-turku-sdsuu-13185967?utm_source=loimu&utm_medium=site

Orion Corporation operates in more than 20 countries, where we Orionees, 3200 in total, work in all kinds of positions. Among us there are Research Scientists, Laboratory Technicians, Engineers and IT Specialists as well as people working in Production, just to mention some examples. We offer diverse and responsible jobs to our personnel in a truly multi-disciplinary work environment. We encourage people to develop their competences and offer opportunities to affect the job description and creating their own career path at Orion. We are searching for top talents who are ready to share our passion for the work that we do.

Description of position

We offer a permanent analytical scientist position in our analytical laboratory in Turku, Finland. We are looking for a research-driven scientist with interest in connecting analytical data with drug substance and product properties. We operate within several therapy areas, i.e. oncology, neurodegeration, pain and animal health.

Your main responsibility is to design and perform chemical analytics and dissolution studies for oral suspensions, liquids and solid dosage forms. You plan and run studies exploring method feasibility and confirming its appropriateness for the intended use. You will review results, summarize and make conclusions of the studies, and document the work for registration purposes according to GMP principles.

You will learn forward-looking biopharmaceutical strategies that enable the development of a high-quality drug substances and drug products through research phase and clinical trials. As well, you will learn the skills of preparing and testing small scale liquid and suspension formulations intended for non-clinical in-vivo testing.

Daily work involves intensive collaboration with internal and external stakeholders working closely together in multi-disciplinary teams. You will follow the international development in this field of science, develop the activities and practices within pharmaceutical research and development, and share your knowledge and experience with your colleagues.

Description of unit

Biopharmaceutics unit consists of analytical, physical-analytical and formulation scientists. We work in research projects for which we develop biopharmaceutical tools and understanding of in-vivo absorption of drug substances. We support drug product development for clinical trials. Biopharmaceutics unit is a part of the Pharmaceutical Research and Development organisation in Orion R&D.

We offer

We offer you the opportunity to join one of the most innovative companies in Finland to use and further develop your expertise in drug and drug product development. We also offer you great colleagues who are driven by the engaging mission of the company and are fun to work with. We foster entrepreneurship, have an open and idea-rich atmosphere with plenty of ways to make a difference. Appreciation of colleagues and continuous development are part of our core values.

Requirements

  • M.Sc. degree in Chemistry, Biochemistry, Pharmaceutical sciences or a related field.
  • Experience of analytical method development with research or pharmaceutical industry.
  • Hands-on experience of performing chemical analytics in laboratory settings.
  • Knowledge of materials sciences and applications in pharmaceutical development preferred.
  • Ability to collaborate well in cross-functional teams internally and in external networks with academia, CROs and partners.

  Fluent communication skills in English are essential.

Additional information

If you interested, please apply at the latest on Thursday 27.5.2021! Inquiries can be done by telephone: Bert van Veen, +358 50 966 4625 (on 17.5. at 14-15 or 24.5. at 14-15).
#LI-ORION

Approved medical examination which also includes drug testing is required prior to the employment.