29.9.2017 | Ajankohtaista
Taimen laboratory, at the Institute of Biomedicine, University of Turku, is looking for a highly motivated graduate student with a background in medicine, biology or biochemistry to join the research group on short notice. The deadline for this application is October 12, 2017 or until the position is filled.
Taimen Lab focuses on nuclear intermediate filaments called lamins and in particular, lamin mutations which cause inherited cardiac diseases such as dilated cardiomyopathy (DCM). So far, we have characterized the pathological effects of mutant lamin using molecular and cellular models. We now move into studying the disease in vivo. We have already generated a Drosophila strain expressing the mutant lamin and preliminary validated the phenotype on fruit fly. Additionally, we are in the process of acquiring a knock-in mouse strain carrying the lamin mutation. These models will allow us to study the molecular mechanisms of DCM in more detail and provide opportunities to test small molecular drugs to inhibit the effects of mutant lamin in vivo.
The recruited doctoral candidate will be characterizing the existing Drosophila model and the underlying molecular mechanisms. Furthermore, the candidate will participate in investigating the phenotype of the mouse model in the future. The work will include cell culture, molecular biology, histology, high resolution imaging and fruit fly and mouse handling. Any previous experience on aforementioned techniques is beneficial but not mandatory for the applicant.
The project is supported by the grant from the Academy of Finland (project funding 2017-2021), Sigrid Juselius Foundation (2017-2019) and Turku University hospital ERVA-funding.
Applications containing a motivation letter (max. 1 page), CV with list of publications (max. 2 pages) and contact information of max. 3 references should be sent as a single pdf to: pekka.taimen@utu.fi
Please further information please contact:
Pekka Taimen, MD, PhD, Adjunct professor in pathology Department of Pathology, University of Turku Kiinamyllynkatu 8-10, 20520 Turku
tel. 02-3131693
Related publications:
West G, Gullmets J, Virtanen L, Li SP, Keinänen A, Shimi T, Mauermann M, Heliö T, Kaartinen M, Ollila L, Kuusisto J, Eriksson JE, Goldman RD, Herrmann H, Taimen P (2016). Deleterious assembly of the lamin A/C mutant p.S143P causes ER stress in familial dilated cardiomyopathy. Journal of Cell Science 129:2732-43.
Alastalo TP, West G, Li SP, Keinänen A, Helenius M, Tyni T, Lapatto R, Turanlahti M, Heikkilä P, Kääriäinen H, Laakso M, Mauermann M, Herrmann H, Pihkala J, Taimen P (2015). LMNA Mutation c.917T>G (p.L306R) Leads to Deleterious Hyper-Assembly of Lamin A/C and Associates with Severe Right Ventricular Cardiomyopathy and Premature Aging. Human Mutation 36:694–703.
Taimen, P., Pfleghaar, K., Shimi, T., Möller, D., Ben-Harush, K., Erdos, M.R., Adam, S.A., Herrmann, H., Medalia, O., Collins, F.S., Goldman, A. and Goldman, R.D. (2009). A Progeria Mutation Reveals Functions for Lamin A in Nuclear Assembly, Architecture and Chromosome Organization. Proceedings of the National Academy of Sciences of the United States of America 106, 20788-20793.
Pekka Taimen, M.D., Ph.D.
Consulting Pathologist
Department of Pathology
University of Turku and Turku University Hospital Kiinamyllynkatu 10
20520 Turku
Finland
tel.(+358)-2-313 1693
mobile. (+358)-50-381 3468
19.9.2017 | Ajankohtaista
https://recruit.ap.uci.edu/apply/JPF04036
RECRUITMENT PERIOD
Open July 1st, 2017 through June 30th, 2018
DESCRIPTION
University of California, Irvine
School of Medicine
Department of Microbiology and Molecular Genetics
Postdoctoral Positions – Microbial Pathogenesis
Post-doctoral scholar positions (Ph.D.) funded by NIH are available immediately to study Chlamydia, the most commonly reported cause of infectious disease in the U.S. Ongoing projects are focused on 1) Developmental regulation: how this bacterium controls its temporal gene expression and conversion between two developmental forms; 2) Host-pathogen interactions (collaboration with Dr. Christine Sütterlin, Dept of Developmental and Cell Biology, UC Irvine): how this intracellular pathogen alters the centrosome, cilia and cell cycle of its infected host cell. Experience in transcriptional regulation, protein purification, cellular microbiology, cell biology or microscopy would be advantageous.
Application procedure – https://recruit.ap.uci.edu/apply/JPF04036
Please include your CV and a cover letter that includes a synopsis of previous research experience, specific interests in the ongoing work and contact information for three references.
The University of California, Irvine is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy.
JOB LOCATION
Irvine, CA
REQUIREMENTS
DOCUMENTS
- Curriculum Vitae – Your most recently updated C.V.
- Cover Letter
- Statement of Research (Optional)
- Statement of Teaching (Optional)
- Statement of Contributions to Diversity – Statement addressing how past and/or potential contributions to diversity will advance UCI’s Commitment to Inclusive Excellence. (Optional)
- Misc / Additional (Optional)
REFERENCES
3-5 references required (contact information only)
HOW TO APPLY
- Create an ApplicantID
- Provide required information and documents
- If any, provide required reference information
18.9.2017 | Ajankohtaista
Nine postdoctoral researcher positions at the University of Eastern Finland – 9 tutkijatohtorin tehtävää
Nine Postdoctoral Researcher positions
The University of Eastern Finland (UEF) is a multidisciplinary university, which seeks to find solutions to global challenges through interdisciplinary research. The UEF has 9 open positions for postdoctoral researchers to carry out their research under the global challenges recognized in the strategy of the UEF:
- Ageing, lifestyles and health
- Learning in a digitised society
- The Cultural encounters, mobilities and borders
- Environmental change and sufficiency of natural resources
In the area of Ageing, lifestyles and health research focuses on Cardiovascular and metabolic diseases, neurosciences, translational cancer research, musculoskeletal disorders, bioinformatics in health sciences and drug targeting technologies (especially on ocular treatments). Research is carried out in multidisciplinary groups under the themes of prediction, prevention, diagnostics, therapy and care, as well as effectiveness and cost effectiveness.
In the area of Learning in a digitised society research focuses on the challenges of learning in the rapidly changing digitalised world, where people should be provided with the abilities of collaborative problem solving, critical and creative thinking, learning skills and information literacy. The research focus is on 1) intelligent and adaptive educational technology (modern teaching technologies and learning environments) and 2) learning of utilization of technologies in teaching and learning processes and 3) active learning in communities under the global transformations.
The Cultural encounters, mobilities and borders area focuses on 1) European borders and Russia, 2) mobilities and migration and 3) cultural and linguistic encounters. In this framework, scientific emphasis is on bordering (the multilevel process of creating political, social and cultural borders) as well as on related socio-cultural transformations and cultural encounters. Interdisciplinary profile combines the methodologies of the humanities and social sciences in order to enhance the formation of shared critical frameworks required to address the new and complex phenomena generated by increased globalisation.
The Environmental change and sufficiency of natural resources area focuses on 1) aerosols and climate change, 2) forests and the bioeconomy and 3) sustainable governance of natural resources. The research will provide novel means, solutions and tools for improving sufficiency and sustainable use of natural resources for the growing needs of the bioeconomy and the society as a whole under the changing operative environment (e.g. climate change).
The University of Eastern Finland invites applications for postdoctoral researcher positions in the research areas mentioned above. The most distinguished and well-suited candidates will be selected. Once selected, the main task of the postdoctoral researcher is to complete the research presented in the research proposal. The postdoctoral researcher will also participate in the supervision of academic theses in their post-doctoral researcher’s field of research, and give teaching in the field in question.
Successful applicants to the postdoctoral researcher positions will hold a doctoral degree, which may not have been completed more than five years before the application deadline (doctoral degree certificate must have been conferred between 20 Oct 2012 and 20 Oct 2017). Applicants who have completed their doctoral degree more than five years ago can be considered only for special reasons (maternity, paternity, parental or childcare leave, military service or non-military service). If the applicant pleads to the above mentioned reasons, he or she needs to explain them in the application. Successful applicants are expected to have experience on research mobility (working in a research environment other than where their doctoral degree has been completed). The applicant should indicate mobility already completed or planned to be completed during the UEF post doctoral period in their application.
The postdoctoral researcher positions will be filled for a three-year term beginning on 1 January 2018. Post-doctoral researcher positions are always filled for a fixed term (UEF University Regulations, Section 31). The salary is based on level 5 of the job requirement level chart of the teaching and research staff in the salary system for Finnish universities (€ 2 865.30/month). In addition to the job requirement component, the salary includes a personal performance component, which may be a maximum of 46.3 % of the job requirement component.
A person can be appointed to a UEF postdoctoral position supported by UEF strategic funding only once.
The application should include:
– A curriculum vitae (e.g. according to: http://www.tenk.fi/en/content/template-researchers-curriculum-vitae)
– A list of publications (e.g. according to: http://www.aka.fi/en/funding/how-to-apply/appendices-required/guidelines-for-list-of-publications/)
– A copy of the PhD diploma/certificate, and
– A research proposal (maximum of 10 pages)
– Possible documents related to research mobility during the UEF post doctoral period
Curriculum vitae, list of publications and research proposal are recommended to be submitted in English.
The applicant should indicate in his or her application the unit in which the work will be completed and his/her contact person/supervisor at the University of Eastern Finland.
Further information:
To find out units, research groups and contact persons:
Ageing, lifestyles and health: maria.pikkarainen@uef.fi, emilia.kansanen@uef.fi
Learning in a digitised society: milena.fayt@uef.fi, riitta.tegelberg@uef.fi
Cultural encounters, mobilities and borders: saija.miina@uef.fi, milena.fayt@uef.fi
Environmental change and sufficiency of natural resources: riitta.tegelberg@uef.fi, ulla.karhunen@uef.fi, saija.miina@uef.fi
Other questions related to the application procedure: anu.liikanen@uef.fi
Evaluation form of the applications used by the University of Eastern Finland: http://www.uef.fi/en/tutkimus/uef-tutkijatohtorit
A probationary period will be applied to new members of the university staff (general regulations on the employment relationship at the University of Eastern Finland, 30 Nov. 2009)
The application needs to be submitted no later than 20 October 2017 (by 24.00 hours Finnish time) by using the electronic application form.
14.9.2017 | Ajankohtaista
Postdoctoral position in Pain Research/Pharmacology
Department of Anesthesiology
Charité – Campus Benjamin Franklin
Berlin, Germany
We are seeking candidates with enthusiasm and interest in pain mechanisms and behavioral and electrophysiological techniques. Our group is interested in translational research on mechanisms of inflammatory, neuropathic and osteoarthritic pain and their control by opioids and neuro-immune interactions.
For selected publications see: Nature Med 2003;8:1003-8; J Neurosci 2006;26:4350-8; J Clin Invest 2008;118:1065-73; J Clin Invest 2009;119:278-86; Pharmacol Rev 2011;63:860-81; Mol Pain 2012, 8:81; J Neurophysiol 2012, 108:2827-36; Brain Behav Immun 2016, 57:227-42; Science 2017, 355:966-9.
The postdoctoral position is part of a collaborative project investigating novel opioid formulations for the control of pain in rodent models and veterinary practice. Experience in behavioral pain testing (e.g., paw pressure, von Frey, Hargreaves tests), side-effect analysis (e.g., conditional place preference) in rodents (rats, mice), and/or electrophysiological techniques (e.g., skin-nerve preparation) is preferable. Laboratory animal science certificate (FELASA or equivalent) is required.
Applicants should hold a PhD or equivalent degree in pharmacology, biology, neuroscience or related fields. Strong research motivation, productivity, the ability to work both independently and as a team member, and proficiency in English are critical. The position is available for 2 years (with possibility of prolongation). Salary is according to E13. Please send a statement of your research interests, CV, and names of two references to:
Prof. Dr. Halina Machelska
Department of Anesthesiology
Charité – Campus Benjamin Franklin
Hindenburgdamm 30
D-12200 Berlin, Germany