Ajankohtaista

Research Director / Senior Researcher, Integrated multiomics

24.1.2022 | Avoimet työpaikat

https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=16&id=000012384&lang=fi

The A. I. Virtanen Institute for Molecular Sciences and the Institute of Biomedicine are institutes housing an international staff of 350 full-time scientists. They are part of the Faculty of Health Sciences at the University of Eastern Finland (UEF) and focus on biomedical research, including neurosciences (see A.I. Virtanen Institute for Molecular Sciences | University of Eastern Finland (uef.fi)  Institute of Biomedicine | University of Eastern Finland (uef.fi))

We are now inviting applications for

Research Director / Senior Researcher, Integrated multiomics

The research is to be done in close collaboration with scientists from different research groups within UEF’s Neuroscience Research Community (NEURO-RC, see https://www.uef.fi/en/research-community/neuroscience-neuro ). The international UEFRAE2019 evaluation panel assessed NEURO-RC to be of outstanding quality in international comparison (score 6/6). The goal of the NEURO-RC is to understand the disease-specific and common molecular mechanisms underlying neurodegenerative diseases and epilepsy, and to identify biomarkers and novel therapeutic approaches for their prevention and cure by merging biological and computational neurosciences. To carry our research beyond state-of-the-art, the NEURO-RC combines unique preclinical and clinical datasets of molecular omics to the mechanistic and biomarker studies conducted in humanized disease models, and multilevel analyses performed using neuro-informatics-based approaches. Moreover, studies related to lifestyle and environmental factors will be integrated to these activities.

The currently open position will strengthen the activities of the university’s strategic research areas. Please see https://www.uef.fi/en/strategy-2030

The Research Director/Senior Researcher will work both as an expert in bioinformatics within the NEURO-RC, and as an independent group leader. The responsibilities also include supervision of doctoral theses, possibly teaching, and acquisition of external funding. We seek applications from highly committed researchers with international experience and an outstanding scientific track record in bioinformatics focused on omics data. An ideal candidate will have a strong background in state-of-the art bioinformatics focused on different kind of omics data (e.g., bulk/scRNA-seq, proteomics, metabolomics, spatial transcriptomics) combined with disease-related genetics. We expect that the candidate can analyze omics data in the multilevel fashion. Furthermore, to gain better insight on genotype-phenotype associations, interrogation of relevant disease models or tissue samples in a single cell level is strongly encouraged. Candidates are welcome to propose a highly innovative research project thematically linked to the scientific mission of the NEURO-RC being complementary to the existing research carried out in the community. The successful candidate is expected to actively collaborate within our interdisciplinary research community and take advantage of the infrastructures and networks available at the UEF. Experience in leading a research team, a strong track record in publishing and gaining research funding and collaborating with other research teams are considered an advantage.

The Research Director/Senior Researcher will be affiliated with Institute of Biomedicine (https://www.uef.fi/en/unit/institute-of-biomedicine) and will have access to the existing research infrastructure. We provide an opportunity to pursue an independent research project for five years. The position includes a yearly budget of 30 000 €/year for personnel and direct project costs for four years.

A person to be appointed as a Research Director/Senior Researcher shall hold a suitable doctoral degree and have good teaching skills. 

The position will be filled for a five-year term starting on 1 March 2022 or as agreed. The position is a fixed-term position due to it pertaining to a specific project. A probationary period will be applied to new members of the university staff. 

The salary of the position is determined in accordance with the salary system of Finnish universities and is based on level 6-7 of the job requirement level chart for teaching and research staff (3,498.98 – 4,033.80), In addition to the job requirement component, the salary includes a personal performance component, which may be a minimum of 6 % and a maximum of 50% of the job requirement component. Depending on the personal performance component, the salary will be approximately 3,708.92 – 4,921.24 €/month at the beginning of the employment relationship. 

For further information on the position, please contact: Mikko Hiltunen, Professor (mikko.hiltunen@uef.fi)

For further information on the application procedure, please contact: Saima-asiatTT@uef.fi

The electronic application should contain the following appendices:

The application needs to be submitted no later than 31.1.2022 (by 24.00 hours Finnish time) by using the electronic application form.

Yliopisto-opettaja, biolääketiede

16.1.2022 | Avoimet työpaikat

https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=16&id=000012282&lang=fi

Haemme lääketieteen laitokselle yliopisto-opettajaa. Työ sijoittuu Kuopion kampukselle ja alkaa 01.06.2022. Lue lisää alta, ja hae viimeistään 31.01.2022. (Hakuajan jatkaminen)

Tehtävä ja palkkaus 

Biolääketieteen yliopisto-opettajan tehtävässä työskentelet lääketieteen laitoksen biolääketieteen yksikössä, Kuopion kampuksella. Laitos kuuluu terveystieteiden tiedekuntaan. Lisätietoja yksikkömme toiminnasta löydät verkkosivuiltamme  https://www.uef.fi/fi/yksikko/biolaaketieteen-yksikko

Yliopisto-opettajan (biolääketiede) tehtäviin kuuluu

  • opetustehtävät biolääketieteen kandidaatti- ja maisterivaiheen koulutuksessa sekä ihmisen biologian opintojaksoilla (kampuksella ja verkkoympäristössä), 
  • biolääketieteen yksikön oppimisympäristön kehittäminen ja toteuttaminen yhteistyössä opettajayhteisön kanssa,
  • tutkinto-opiskelijoiden opinto-ohjaus,
  • opinnäytetöiden ohjaaminen ja tarkastaminen,
  • tutkimustyö biolääketieteen yksikössä sekä
  • hallinnolliset tehtävät yksikkö- ja laitostasolla

Tehtävä täytetään määräajalle 01.06.2022 – 31.05.2026. Määräaikaisuuden perusteena on 2021 toteutunut määräaikainen koulutuslaajennus sekä opetustyön uudelleen organisointi yksikössä. Uuden työntekijän tullessa tehtävään käytetään koeaikaa. 

Tehtävän palkkaus määräytyy yliopistojen opetus- ja tutkimushenkilöstön palkkausjärjestelmän mukaisesti. Palkka koostuu tehtäväkohtaisesta palkanosasta ja henkilökohtaiseen suoriutumiseen perustuvasta palkanosasta. Tässä tehtävässä tehtäväkohtainen palkanosa on vaativuustasoluokittelussa tasoilla 4 – 5 (2591,28 – 3000,49 €). Lisäksi maksetaan henkilökohtaiseen suoriutumiseen perustuvaa palkanosaa, joka on 6 – 50 % tehtäväkohtaisesta palkanosasta. Henkilökohtaisesta palkanosasta riippuen palkka työsuhteen alkaessa on noin 2850,40 – 3660,60 €/kk.  

Mitä edellytämme ja toivomme sinulta? 

Edellytämme sinulta 

  • työtehtävään soveltuvaa ylempää korkeakoulututkintoa sekä hyvää opetustaitoa,
  • hyvää suomen- ja englanninkielen suullista ja kirjallista taitoa,
  • kokemusta alan yliopisto-opetuksesta,
  • hyviä yhteistyö- ja kommunikointitaitoja,
  • kiinnostusta akateemista uraa kohtaan

Katsomme eduksi 

  • pedagogisen koulutuksen,
  • tutkimusansiot,
  • kiinnostuksen osallistua tutkimustyöhön biolääketieteen yksikössä toimivassa tutkimusryhmässä

Tarjoamme sinulle 

  • mielenkiintoisen ja monipuolisen työtehtävän osana kansainvälistä, luovaa, osallistuvaa ja osallistavaa yliopistoyhteisöä, 
  • mahdollisuuden joustavaan monipaikkatyöhön sekä
  • Itä-Suomen yliopiston henkilöstöedut, joihin kuuluvat muun muassa kattava työterveyshuolto, laaja henkilöstökoulutustarjonta, edulliset kampusravintolalounaat ja Sykettä-liikuntapalvelut  

Hae näin 

Jätä hakemus viimeistään 31.01.2022 sähköisellä hakulomakkeella. 

Huomioi, että hakemukseen tulee liittää mukaan: 

Kysymyksiä? 

Lisätietoja tehtävästä antavat biolääketieteen yksikön johtaja Anitta Mahonen, p. +358 29 445 4243, anitta.mahonen@uef.fi 

Lisätietoja hakemisesta ja hakuprosessista antaa HR-sihteeri Minna Leskinen, p. +358 29 445 4278, minna.k.leskinen@uef.fi. 

Postdoctoral Researcher / Project Researcher / Early Stage Researcher (Biomedical Informatics)

14.12.2021 | Avoimet työpaikat

https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=16&id=000012134&lang=fi

The University of Eastern Finland is inviting applications for a Postdoctoral Researcher / Project Researcher / Early Stage Researcher (Biomedical Informatics) position in Kuopio. The position will be filled for a two-year term from 1 January 2021 (or as agreed). Please find more information below and submit your application no later than 28 December 2021. (Extended application period)

Role and salary

As our new Postdoctoral, Project or Early Stage Researcher in Biomedical Informatics, you will be working in the research group led by Associate Professor and Academy Research Fellow Vittorio Fortino in the Institute of Biomedicine, School of Medicine, Faculty of Health Sciences, Kuopio Campus.

Our group studies and implements data mining algorithms (including machine learning algorithms) to tackle biomedical questions, such as biomarker and drug discovery. Applicants with profound knowledge of (1) bioinformatics tools to analyse genomics and transcriptomics data; and (2) machine learning algorithms are encouraged to apply.

More details on the research group and research interests can be found at 

The successful candidate will work on a project funded by Jane and Aatos Erkko Foundation. 

https://www.uef.fi/en/article/precision-cancer-medicine-with-machine-learning-and-ai

The position is part of a project aiming to develop machine learning approaches

1)      to identify clinically relevant cancer subtypes from multi-omics datasets (TCGA);

2)      to learn how to match cancer cell lines with cancer subtypes via omics data (TCGA, CCLE, GDSC, and GTEx); and

3)      to discover synergistic (and safer) drug combinations from available pharmacogenomics data (e.g. LINCS 1000).

The position will be filled for a two-year term from 1 January 2021 (or as agreed) due to it pertaining to a specific project.  A probationary period is applied to all new members of the staff.

The salary of the position is determined in accordance with the salary system of the Finnish universities. The salary comprises two components: a job requirement component and a personal performance component. For a Postdoctoral Researcher / Project Researcher, the job requirement component is 3,000.49 €/month, based on level 5 of the job requirement chart for teaching and research staff. For an Early-stage Researcher, the job requirement component is 2,078.27 – 2,591.28 €/month, based on levels 2-4 of the job requirement chart for teaching and research staff. The personal performance component can be between 6-50 % of the above-mentioned sums.

At the beginning, the salary will be 3,180.52 – 3,660.60 € /month, as Postdoctoral / Project Researcher or 2,202.97-2,746.76 € /month as Early-Stage Researcher.

Our requirements and expectations

The appointed researcher will have a central role in implementing and applying machine learning methods for the analysis of large-scale omics data. They will have an inquisitive mindset, a proactive attitude, and the desire to further develop their skills for data science and machine learning.

The successful candidate will:

  • Have a PhD in Bioinformatics, Computational Science or a related discipline for the Postdoctoral/Project Researcher position. If the doctoral degree has been awarded less than five years ago, the post will be one of a Postdoctoral Researcher. If the doctoral degree has been awarded more than five years ago, the post will be one of a Project Researcher. In this context, the 5 years refer to a net period time, which does not include parental leaves, or military service.
  • Have an MSc in Bioinformatics, Biosciences or a related discipline for the Early Stage Researcher position; have completed a suitable higher university degree or an equivalent education abroad which in the country in question would qualify the person for similar academic studies. The candidate shall also be qualified to pursue postgraduate studies at the University of Eastern Finland by enrolling in one of the doctoral programmes of the Faculty of Health Sciences.

Desired knowledge, skills, and abilities that are essential for this position:

  • A solid computational (informatics/computer science/coding) background is required..
  • Solid knowledge of, and practical experience in, bioinformatics is required.
  • Experience of analysis of at least two different types of omics data (e.g. gene expression data, genomic data – GWAS, DNA methylation data, etc.) is required.
  • Programming experience in a relevant programming language (e.g., R and Python) is required.
  • Practical experience of working with machine learning methods is required.
  • Practical experience of working with network analysis is an advantage.
  • Applicants must be able to work independently and in a team.
  • Applicants must have good skills in oral and written English.
  • Previous research experience and ambitions will also count during the evaluation process.

Your benefits

You will have access to the university’s staff benefits, including

  • extensive occupational health care
  • staff discount on lunch in our campus restaurants, as well as on a range of other
    services
  • affordable sports services.

Please read more in the Work at UEF section on our website. https://www.uef.fi/en/university#paragraph-4467

How to apply? 

Submit your application by using our electronic application form no later than 28.12.2021 (by24.00 hours Finnish time).

 Please note that you must include the following appendices in your application:

Questions?

For further information on the position, please contact: Associate Professor Vittorio Fortino, +358 29 445 4197,  vittorio.fortino@uef.fi.

For further information on the application procedure, please contact  Saima-asiatTT@uef.fi

Early Stage Researcher

12.11.2021 | Avoimet työpaikat

https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=16&id=000012100&lang=fi

The University of Eastern Finland is inviting applications for an Early Stage Researcher position in Kuopio. The position will be filled for a fixed term of three years starting in January 2022, or as agreed. Please find more information below and submit your application no later than 15.11.2021.

Role and salary

As our new Early Stage Researcher, you will be working in the School of Pharmacy, at the Faculty of Health Sciences. The position is mainly located in Kuopio, Finland. The position includes a research visit abroad.

We are applying for a highly motivated professional to work in the Leinonen Retina Laboratory. The applicant will be working in a project that aims to solve basic mechanisms of homeostatic plasticity in the nervous system. The applicant will evaluate homeostatic plasticity and functional adaptation of the retina in response to damage to the sensory photoreceptors and subsequently the cellular mechanisms explaining the phenomenon. The research tasks include eye imaging and measurement of visual function in animal models, electrophysiological techniques, basic molecular biology assays as well as state-of-the-art bioinformatics methods such as single-cell RNA-sequencing. The project will be performed in close collaboration with the University of Utah (UofU, Salt Lake City, Utah, USA) and part of the data collection will be conducted during a research visit to UofU.

The research tasks will include:

  • Bioinformatics from proteomics and single-cell RNA-sequencing data
  • Basic molecular biology methods such as immunohistochemistry, western blotting, quantitative RT-PCR, RNA-sequencing
  • Vision assessment in laboratory animals: electroretinography, cortical visual evoked potentials, behavioural vision tests
  • Electrophysiology in isolated retinas
  • Drug trials in animal models

More information about the principal investigator: https://uefconnect.uef.fi/en/person/henri.leinonen/

The position is initially filled for a fixed term of three years starting in January 2022, or as agreed. The position is full-time, enabling full-time work on the doctoral dissertation. Early Stage Researcher positions are always filled for a fixed term. A probationary period is applied to all new members of the staff.

The salary of the position is determined in accordance with the salary system of the Finnish universities. The salary comprises two components: a job requirement component and a personal performance component. The Early Stage Researcher position is based on level 2 – 4 of the job requirement level chart for teaching and research staff (2,078.27 – 2,591.28 €/month). The personal performance component can be a minimum of 6 % and a maximum of 50 % of the above-mentioned sum. The estimated salary in the beginning of the employment will be 2,300 – 2,800 €/month. The salary of the Early Stage Researcher depends on the phase of the doctoral dissertation and postgraduate studies as well as personal performance.

Requirements and expectations

  • relevant Master’s degree with a firm training in neuroscience, pharmacology, molecular biology, biomedicine or equivalent field. Experience in in vivo work will be the greatest advantage for the position.
  • fluent English language skills
  • adaptability to work both independently and as a team member
  • preparedness for an international research exchange (to USA) 

Additional strengths (non-mandatory) of the applicant include knowledge of statistical methods and software and project management skills.

What we can offer you 

You will have an opportunity to work in an interesting role as part of our international, creative, participatory and inclusive academic community. In addition, you will have access to the University’s staff benefits, including:

  • extensive occupational health care 
  • staff discount on lunch in our campus restaurants, as well as on a range of other services 
  • affordable sports services  

Please read more in the Work at UEF section on our website

How to apply

The application needs to be submitted no later than 15.11.2021 (by 24.00 hours Finnish time) by using the electronic application form.

Please note that you must include the following appendicesin your application:

In addition, attaching at least two reference letters is highly encouraged.

Questions?

For further information on the position, please contact Academy Research Fellow Henri Leinonen, henri.leinonen@uef.fi, +358 29 445 4218

For further information on the application procedure, please contact HR Secretary, Sari Palviainen, sari.palviainen@uef.fi, +358 29 445 4324

Early Stage Researcher

12.11.2021 | Avoimet työpaikat

https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=16&id=000012095&lang=fi

The University of Eastern Finland is inviting applications for an Early Stage Researcher position on the Kuopio Campus. The position will be filled for a four-year term from 1 December 2021 (or as agreed) to 30 November 2025. Please find more information below and submit your application no later than 16 November 2021.

Role and salary

As our new Early Stage Researcher  you will be working at the A.I. Virtanen Insitutute for Molecular Sciences, Faculty of Health Sciences. The position is located in Kuopio, Finland.  

Untangling the wiring diagram of the human brain offers exciting new opportunities to better understand how our brains work and what kind of changes occur during various brain disorders, including mental and neurodegenerative diseases. Owing to recent advances in neuroimaging technology, particularly in diffusion magnetic resonance imaging (MRI), it is now possible to study the structural connectivity network of the brain. To that end, our group develops novel computational algorithms to process neuroimaging data and to analyse brain networks using signal processing and machine learning techniques. Coding plays a vital role in our research to enable clinical and widespread use of our tools. Software developed by our group have won several awards in previous international competitions. 

We are looking for an Early Stage Researcher to work at the intersection of neuroscience and machine learning. The specific research topic is highly novel and it involves processing of MRI data and network analysis. The novel techniques that will be developed by the Early Stage Researcher will contribute to our software development effort as well. With that, we foresee a large number of clinical applications, Alzheimer’s disease being the potential primary target for investigation.

A person to be appointed as an Early Stage Researcher shall be qualified to pursue postgraduate studies, i.e. he or she is required to have completed a suitable higher university degree or an equivalent education abroad which in the country in question would qualify the person for similar academic studies. 

The position is filled for a four-year term from 1 December 2021 (or as agreed) to 30 November 2025. Positions of Early Stage Researchers shall always be filled for a fixed term.The position is filled for a fixed term because in the University of Eastern Finland, the objective is to complete the doctoral degree in a maximum of four years. A probationary period is applied to all new members of the staff. The salary of the position is determined in accordance with the salary system of Finnish universities and is based on 2 – 4 of the job requirement level chart for teaching and research staff (2,078.27 – 2,591.28 €/month). In addition to the job requirement component, the salary includes a personal performance component, which can be a minimum of 6 % and a maximum of 50 % of the job requirement component. Depending on the job requirement component and the personal performance component, the salary will be approximately 2,203.00 – 2,535.00 €/month at the beginning of the employment relationship.

Your benefits  

You will have access to the university’s staff benefits, including  

  • extensive occupational health care  
  • staff discount on lunch in our campus restaurants, as well as on a range of other services  
  • affordable sports services.  

Please read more in the Work at UEF section on our website.  

You will have an opportunity to work in an interesting role as part of our international, creative, participatory and inclusive academic community.    

How to apply?  

Submit your application by using our electronic application form no later than 16 November 2021 (by 24.00 hours Finnish time).     

Please note that you must include the following appendices in your application  

Questions?   

For further information on the position, please contact: Dr Dogu Baran Aydogan,  +358 45 8826216,  baran.aydogan@uef.fi.

For further information on the application procedure,
please contact Tarja Salmi, +358 29 4458220, tarja.salmi@uef.fi.

Early Stage Researcher, Non-coding RNAs in the brain

28.7.2021 | Avoimet työpaikat

https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=16&id=000011461&lang=fi

We are now inviting applications for an Early Stage Researcher (Doctoral Student) position in the EU-funded Marie Skłodowska-Curie Cofund DP project Neuro-Innovation: Research and innovation for brain health throughout life. The position in the A. I. Virtanen Institute for Molecular Sciences will start in early 2022. Read more below and submit your application no later than 15 August 2021. 

This position is one of the 7 PhD positions available for highly motivated Early Stage Researchers (ESRs) in the Neuro-Innovation project in the Kuopio campus of the university. In the Faculty of Health Sciences, a total of four Early Stage Researcher positions will be filled in this first call. One of these positions will be filled by a person selected for the Doctoral Programme of Molecular Medicine (DPMM). The number of ESRs selected in the Faculty of Health Sciences, will be determined during the selection process and may change from what has initially been announced based on the eligibility of the applicants and the scoring of the applications.

The A.I. Virtanen Institute for Molecular Sciences is a research institute that responds to the global health challenges created by the aging of the population and changes in lifestyle by focusing on the research of cardiovascular and brain diseases. The Doctoral Programme in Molecular Medicine (DPMM) is an interdisciplinary doctoral training program with the purpose of training researchers as international experts in modern biomedicine.

Role and salary

The selected ESR will work in a young enthusiastic research team focusing on RNA biology. Our research goal is to understand the molecular mechnisms of non-coding RNAs and unveil their role in normal brain and diseases. We are especially interested on epileptogenesis and drug-refractory epilepsy. Most of the research is done in experimental laboratory models. However, we also examine tissue from patients as we work in collaboration with the Kuopio University Hospital and Veterinary Teaching Hospital (Helsinki). In our studies we apply together with our collaborators various methods that range from classical immunohistochemistry and in situ hybridization, molecular profile analysis (next generation sequencing, proteomics), RNA techniques (PCR, RNA manipulation) to bioinformatics, behavioural analysis and magnetic resonance imaging. 

The position in the Doctoral Programme of Molecular Medicine (DPMM) is offered for the research topic of Non-coding RNAs: Mechanisms and therapeutic strategies for epilepsy. You may modify this research topic or suggest your own topic in the motivation letter (for details, see the Neuro-Innovation website). The main duty of the ESR is to complete a doctoral dissertation in accordance with the research proposal written in the beginning of the employment period. In the University of Eastern Finland, the objective is to complete the doctoral degree in a maximum of four years of full-time study. The position will be filled for a fixed term of four years starting from early 2022 or as agreed upon with the PhD candidate. Early Stage Researcher positions are always filled for a fixed term. A probationary period is applied at the University of Eastern Finland to all new members of the staff.  

The salary of the position is based on the salary system for the teaching and research staff at universities. The salary consists of the job-related salary element and the personal performance salary element. For this position, the job requirement level used to determine the job-related salary element is 2–4, and the personal performance salary element is 6–50% of the job-related salary element. The estimated monthly salary in the beginning of the employment will be 2,288.17 – 3,163.95 €/per month. The salary of an ESR depends on the phase of the doctoral dissertation and postgraduate studies as well as personal performance.

What we expect and wish from you 

We are looking for an ESR with passion for excellence in research, innovation, and societal impact. We are looking for a motivated candidate to work on a unique project that identifies and characterizes novel molecular mechanisms of non-coding RNAs and investigates their role during epileptogenesis. The candidate will have possibility to unveil fundamental aspects non-coding RNA and discover new treatment strategies to prevent or halt epileptogenesis and drug-refractoriness. There is also a possibility to assess biomarkers at different stages of the disease. The academic profile of the candidate should be in the molecular biology area, with the idea of complementing this background throughout PhD studies. The candidate must be motivated to combine complementary areas of knowledge in neurosciences, data sciences and business to success in the thesis project. 

The person appointed as an ESR must hold an appropriate higher university degree or an equivalent degree that would qualify the person for doctoral studies. 

Requirements for doctoral candidates:

  • hold a Master’s Degree (or equivalent) and a research thesis (or equivalent) in molecular biology, or another related relevant field
  • should not hold a doctorate or PhD
  • should have less than 4 years of research experience after the graduation (Master’s Degree or equivalent based on which you are applying for this position) by August 15th, 2021. In this context, the 4 years refer to a net period of time, which does not include maternity leaves, parental leaves or military service.
  • excellent command of the English language is required

Mobility requirements for doctoral candidates: 

  • fulfil the mobility requirement of the MSCA actions, i.e. ESRs must not have resided or carried out their main activity (work, studies) in Finland for more than 12 months in the 3 years immediately before August 15th, 2021. Compulsory national service and/or short stays such as holidays are not considered.

What we can offer you   

  • An interesting position in an international, creative, participatory and engaging university community 
  • The possibility of flexible multi-location work 
  • Staff benefits of the University of Eastern Finland, including comprehensive occupational health care, versatile staff training opportunities, affordable campus restaurant lunches and Sykettä sports services 

How to apply  

The application shall be submitted no later than 15 August 2021 by 24:00 hours Finnish time (11:00 pm CEST) by using the electronic application form. 

The objective is to offer the position to the most merited applicant by January-February 2022. 

Please note that the application is required to include the following appendices: 

  • certified copies of BSc and MSc degree diplomas/certificates and copies of these relating to applicant’s language proficiency (if not indicated in the academic degree), transcripts of these records in English. if the proof of English language skills has not been demonstrated in an academic degree and the applicant has not taken the English language test, the English language skills will be assessed in the interview for the position.
  • curriculum vitae (CV) (https://tenk.fi/en/advice-and-materials/template-researchers-curriculum-vitae)
  • Master’s thesis (in any language), electronic copy (in zip file)
  • two-page summary of the Master’s thesis in English (in pdf file)
  • motivation letter (max three pages) describes the applicant’s motivation to pursue PhD studies in the chosen research area and topic. When suggesting your own research topic or modifications to the given topic, the research idea needs to be described as part of the motivation letter and research ethics and infrastructure forms provided on the programme website must be attached to the application (for more specific instructions on the motivation letter, see www.uef.fi/neuro-innovation

Questions?  

For further information on the position and the research topic for which it is offered, please visit www.uef.fi/neuro-innovation

For further information on the application procedure, see the FAQ section on the Neuro-Innovation website or send email to neuroinno@uef.fi.

Early Stage Researcher, Neuroinflammation research

28.7.2021 | Avoimet työpaikat

https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=16&id=000011456&lang=fi

We are now inviting applications for an Early Stage Researcher (Doctoral Student) position in the EU-funded Marie Skłodowska-Curie Cofund DP project Neuro-Innovation: Research and innovation for brain health throughout life. The position in the A. I. Virtanen Institute for Molecular Sciences will start in early 2022. Read more below and submit your application no later than 15 August 2021.

This position is one of the 7 PhD positions available for highly motivated Early Stage Researchers (ESRs) in the Neuro-Innovation project in the Kuopio campus of the university. In the Faculty of Health Sciences, a total of four Early Stage Researcher positions will be filled in this first call. One of these positions will be filled by a person selected for the Doctoral Programme of Molecular Medicine (DPMM). The number of ESRs selected in the Faculty of Health Sciences, will be determined during the selection process and may change from what has initially been announced based on the eligibility of the applicants and the scoring of the applications. 

The A.I. Virtanen Institute for Molecular Sciences is a research institute that responds to the global health challenges created by the aging of the population and changes in lifestyle by focusing on the research of cardiovascular and brain diseases. The Doctoral Programme in Molecular Medicine (DPMM) is an interdisciplinary doctoral training program with the purpose of training researchers as international experts in modern biomedicine.

Role and salary

The selected ESR will work in the Neuroinflammation research group the goal of which is to understand inflammatory cell functions, especially those of microglia and astrocytes and mechanisms and mediators of inflammatory reactions in neurodegenerative diseases, such as Alzheimer’s disease. We use interdisciplinary approaches to find novel targets for modulation of neuroinflammation for disease benefit. We aim to form a functional fingerprint of microglia-neuron crosstalk in health and disease. We use novel, human-based models and develop new human iPSC-based models including microglia and immunocompetent organoids and use living human brain biopsies. We investigate cellular responses using various omics approaches, electrophysiology and microscopy techniques. (for more details, see https://uefconnect.uef.fi/en/group/neuroinflammation-research-group/)

The position in the Doctoral Programme of Molecular Medicine (DPMM) is offered for the research topic of Mechanisms and biomarkers of Early Alzheimer’s disease –use of human data ethically sustainable manner. You may modify this research topic or suggest your own topic in the field of neuro-innovation in your motivation letter. The main duty of the ESR is to complete their doctoral dissertation in accordance with their research proposal written in the beginning of the employment period. In the University of Eastern Finland, the objective is to complete the doctoral degree in a maximum of four years of full-time study. The position will be filled for a fixed term of four years starting from early 2022 or as agreed upon with the candidate. ESR positions are always filled for a fixed term. A probationary period is applied to all new members of the staff.

The salary of the position is based on the salary system for the teaching and research staff at universities. The salary consists of the job-related salary element and the personal performance salary element. For this position, the job requirement level used to determine the job-related salary element is 2–4, and the personal performance salary element is 6–50% of the job-related salary element. The estimated monthly salary in the beginning of the employment will be 2,288.17 – 3,163.95 €/per month.  The salary of an ESR depends on the phase of the doctoral dissertation and postgraduate studies as well as personal performance.

What we expect and wish from you   

We are looking for an ESR with passion for excellence in research, innovation, and societal impact. We welcome highly motivated candidate to characterize the impact of Aβ and/or Tau pathology on cellular functions. You will be working with human-based in vitro models, state-of-the-art technologies to measure neuronal functionality, clinical data and/or transcriptomic and single cell sequencing data analysis. The entire study is carried out using human samples and data. You will join a very active and well-equipped group of neuroscientists studying various aspects of neuronal function and neuroinflammation in the context of different neurological diseases. The project aims to tackle issues related to GDPR and ethics, and in addition, data sharing are taking into account throughout the project. The ESR must be willing to combine some complementary areas of knowledge in business studies, data science, social science, applied physics and/or law to complete the thesis project.  

The person appointed as an ESR must hold an appropriate higher university degree or an equivalent degree that would qualify the person for doctoral studies.

Requirements for doctoral candidates: 

  • hold a Master’s Degree (or equivalent) and a research thesis (or equivalent) in neurobiology or biomedicine, or another related relevant field
  • should not hold a doctorate or PhD
  • should have less than 4 years of research experience after the graduation (Master’s Degree or equivalent based on which you are applying for this position) by August 15th, 2021. In this context, the 4 years refer to a net period of time, which does not include maternity leaves, parental leaves or military service.
  • excellent command of the English language is required

 Mobility requirements for doctoral candidates:

  • fulfil the mobility requirement of the MSCA actions, i.e. ESRs must not have resided or carried out their main activity (work, studies) in Finland for more than 12 months in the 3 years immediately before August 15th, 2021. Compulsory national service and/or short stays such as holidays are not considered.

What we can offer you   

  • An interesting position in an international, creative, participatory and engaging university community 
  • The possibility of flexible multi-location work 
  • Staff benefits of the University of Eastern Finland, including comprehensive occupational health care, versatile staff training opportunities, affordable campus restaurant lunches and Sykettä sports services 

How to apply  

The application shall be submitted no later than 15 August 2021 by 24:00 hours Finnish time (11:00 pm CEST) by using the electronic application form. 

The objective is to offer the position to the most merited applicant by January-February 2022.

 Please note that the application is required to include the following appendices: 

  • certified copies of BSc and MSc degree diplomas/certificates and copies of these relating to applicant’s language proficiency (if not indicated in the academic degree), transcripts of these records in English. if the proof of English language skills has not been demonstrated in an academic degree and the applicant has not taken the English language test, the English language skills will be assessed in the interview for the position.
  • curriculum vitae (CV) (Template for researcher’s curriculum vitae | Finnish National Board on Research Integrity TENK
  •  Master’s thesis (in any language), electronic copy (in zip file)
  •  two-page summary of the Master’s thesis in English (in pdf file)
  •  motivation letter (max three pages) describes the applicant’s motivation to pursue PhD studies in the chosen research area and topic. When suggesting your own research topic or modifications to the given topic, the research idea needs to be described as part of the motivation letter and research ethics and infrastructure forms provided on the programme website must be attached to the application (for more specific instructions on the motivation letter, see www.uef.fi/neuro-innovation

Questions?  

For further information on the position and the research topic for which it is offered, please visit www.uef.fi/neuro-innovation

For further information on the application procedure, see the FAQ section on the Neuro-Innovation website or send email to neuroinno@uef.fi

Early Stage Researcher, Neurobiology of Disease – University of Eastern Finland

15.7.2021 | Avoimet työpaikat

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 101034307.

PROPOSED TOPIC FOR PHD
New biomarkers for mental health

DOCTORAL PROGRAMME
Doctoral Programme of Molecular Medicine (DPMM)

THE PRIMARY SUPERVISOR AND CO-SUPERVISORS
Katja Kanninen, primary supervisor
Izaque de Sousa Maciel, postdoc in the Kanninen research group
Päivi Eriksson
Noora Puhakka

HOST RESEARCH UNIT AND HOST RESEARCH TEAM AT THE UNIVERSITY OF EASTERN FINLAND (UEF)

A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences

The goal of the ‘Neurobiology of Disease’ research group is to provide in-depth understanding of the cellular and molecular events that occur in brain disorders. By using human biosamples we aim to discover biomarkers for mental health dysfunction in order to provide novel solutions for patient benefit. Biomarker discovery is facilitated by using highly sophisticated, integrative omics approaches. Validation and detailed testing is carried out in human cells, and animal disease models. We are increasingly interested in deciphering how environmental factors shape the brain and affect mental health.

EXPECTED PROFILE OF THE PHD CANDIDATE
This research project needs the participation of people with passion for excellence in research, innovation, and societal impact. We are looking for candidates who seek to contribute to brain health innovation research with a keen eye on the application of research knowledge to the problems and challenges of society and industry. Ideal candidates want to open their minds to intersecting and complementary fields of science, seeking a multi/interdisciplinary approach in research. The candidates should have a desire to approach the brain health industry and other organizations that will benefit from science when developing services, products, and processes.

The academic profile of the candidate should be in the neuroscience or biomedicine, with the idea of complementing this background throughout PhD studies. Overall, the candidate must be willing to combine complementary areas of knowledge in innovation management, data sciences, social sciences, applied physics and/or law to complete the thesis project. Moreover, the candidate is required to have good methodological skills, especially in longitudinal analyses. As far as soft skills are concerned, we welcome candidates with a proactive, collaborative attitude, and who are enthusiastic about building, creating, and working in teams. Excellent candidates desire to participate in activities concerning multi- and interdisciplinary ageing research, and are willing to spend some time abroad with our international partners and outside the university in our partner institutions.

We are looking for a motivated candidate to work on a highly novel project that identifies, validates and characterizes new omic biomarkers for childhood and adolescence mental illness using human-based biosamples and animal models of neuropsychiatric disorders. You will be working with biosamples and omics data from children and adolescents that are at high risk of a mental health disorder, or that already have a diagnosis. If you wish, you may also join our animal studies on neuropsychiatric disease. You will join a very active and multidisciplinary, European-wide team of scientists (funded by Horizon 2020, project Equal-Life) studying various aspects of the exposome in relation to mental health. The project aims to tackle issues related to commercialization of novel biomarkers throughout the project. We expect you to have an inquisitive attitude and the ability to work in a highly dynamic, interdisciplinary team. A suitable background in neuroscience, omics approaches, bioinformatics or related fields are highly appreciated.

SCIENTIFIC RESEARCH AREAS RELATED TO THE TOPIC
Neuroscience, biomarkers, mental health, innovation, bioinformatics

DESCRIPTION OF THE NEURO-INNOVATION RESEARCH TOPIC
Adolescence is a crucial period for developing and maintaining social and emotional habits important for mental well-being. Some adolescents are at greater risk of mental health conditions due to their living conditions, lifestyle, genetic factors, and the environment they are exposed to. The goal of this research is to demonstrate proof of concept in being able to utilize newly discovered biomarkers for the early detection and risk stratification of mental dysfunction, especially targeting adolescents. This project will determine the utility and validity of novel biomarkers discovered by multiomic approaches for early identification of at-risk individuals and possible preventative measures. Additional functional data on the biomarkers will be generated with human biosamples and highly translational research models. The project also combines the biomarkers data on the living conditions of the adolescents. A key aspect of this project is to determine if the biomarkers have utility for risk prediction and commercialization potential. This project strives to meet the challenging outstanding medical need of early identification of mental health dysfunction in adolescence.

The candidate can also suggest their own topic or modify this topic in their motivation letter.

EXCELLENCE OF THE HOST RESEARCH TEAM

Publications related to the PhD topic

  • Lampinen R, Feroze M, Avesani S, Örd T, Penttilä E, Lehtola J-M, Saari T, Hannonen S, Saveleva L, Kaartinen E, Fernandes Acosta F, Cruz-Haces M, Löppönen H, Mackay-Sim A, Malm T, Kaikkonen-Määttä M, Koivisto AM, White AR, Giugno R, Chew S, Kanninen KM. Disease specific alterations in the olfactory mucosa of patients with Alzheimer’s disease. doi: https://doi.org/10.1101/2020.11.24.395947.
  • Kanninen KM, Lampinen R, Rantanen LM, Odendaal L, Jalava P, Chew S, White AR. Olfactory cell cultures to investigate health effects of air pollution exposure: Implications for neurodegeneration. Neurochem Int. 2020 Jun;136:104729. doi: 10.1016/j.neuint.2020.104729. Epub 2020 Mar 19. PMID: 32201281.
  • Chew S, Lampinen R, Saveleva L, Korhonen P, Mikhailov N, Grubman A, Polo JM, Wilson T, Komppula M, Rönkkö T, Gu C, Mackay-Sim A, Malm T, White AR, Jalava P, Kanninen KM. Urban air particulate matter induces mitochondrial dysfunction in human olfactory mucosal cells. Part Fibre Toxicol. 2020 Jun 1;17(1):18. doi: 10.1186/s12989-020-00352-4. PMID: 32487172; PMCID: PMC7268298.
  • Das Gupta S, Ciszek R, Heiskanen M, Lapinlampi N, Kukkonen J, Leinonen V, Puhakka N, Pitkänen A. Plasma miR-9-3p and miR-136-3p as Potential Novel Diagnostic Biomarkers for Experimental and Human Mild Traumatic Brain Injury. Int J Mol Sci. 2021 Feb 4;22(4):1563. doi: 10.3390/ijms22041563. PMID: 33557217; PMCID: PMC7913923.
  • Lehtimäki, H., Helén, I., Snell, K., Eriksson, P., & Montonen, T. (2019). Sustainable Value Creation in the Commercialization of Innovation: The Case of Auria Biobank. International Journal of Entrepreneurship and Innovation Management¸23(5), 451-465.

Research projects related to the PhD topic

MULTI/INTERDISCIPLINARY COLLABORATION
This PhD research topic covers the following complementary areas of knowledge: basic neuroscience, mental health, biomarker discovery, neuroinnovation, bioinformatics

The PhD project will be co-supervised by a team of 3 scientists with expertise in basic neuroscience, biomarker discovery, neuroinnovation and bioinformatics.

To advance multi/interdisciplinary collaboration, three Summer Schools will be organised jointly by the Neuro-Innovation supervisors and non-academic partners. In these, multi-/interdisciplinarity and intersectoral exchange will be implemented via hands-on interaction between PhD students, supervisors, partners and other stakeholders.

  • Neuro-ethics and patient rights, 3 ECTS credits. Research ethics, patient rights, data security.
  • Neuro-data Hackathon, 3 ECST credits. Open and big data.
  • Neuro-Innovation Living Lab, 3 ECST credits. Entrepreneurial processes and commercialisation paths.

Virtual Platform for multi/interdisciplinary interaction will connect all PhD students in this programme.

INTERNATIONAL COLLABORATION
The academic partner organizations (see the Neuro-Innovation webpage) will collaborate closely with us in PhD training and students are strongly encouraged to include a secondment and visits with these partners in their studies. During shorter visits (1-4 weeks), you will learn more about research and methods and build international networks. During secondments, you will work on their research project under the supervision of the co-supervisor from the hosting organisation and utilise their infrastructure. You can also attend courses, seminars, and other events in the host organisations.

The PhD candidate has the opportunity to visit one or two project partners for secondments, for example the University of Verona and BioTalentum Ltd, for a period that will be jointly agreed. This will enable the candidate to become familiar with the state-of-the-art methodologies in human biosampling and bioinformatics and gain knowledge in working in industrial settings.

INTERSECTORAL COLLABORATION

The Societal Impact Board of this PhD programme with 14 intersectoral partners will collaborate closely with us in PhD training, for instance on the following activities:

  • Neuro-Innovation Talent Hub: monthly gathering with special guests (e.g., researchers, professionals, business experts, stakeholders) and discussions about research topics and career prospects.
  • Neuro-Innovation Boot Camp: yearly competition concerning the utilisation of research results.

There is a particularly close collaborative relationship planned with BioTalentum Ltd as well as University of Verona in the proposed topic.

Close collaboration with clinicians, psychologists, bioinformaticians and innovation experts during the doctoral studies is highly recommended.

Apply the position

IMPACT
High quality research and publications of excellence are a way to solve scientific and societal problems and challenges. This vision is shared by the collaborating partners in this doctoral program, and involvement with various stakeholders will allow the pursuit of a goal with potential for brain health innovation. The University of Eastern Finland pursues societal impact that goes beyond academia focusing on the transformation of society, leading to fairer and more diverse societies, where inclusive social development and welfare are enhanced.

The objective of the proposed research is to advance our understanding of mechanisms of mental health dysfunction and discover and validate biomarkers to serve both diagnostic and potential therapeutic purposes. In the long run, the data from this study can be used to categorize individuals to risk groups, aid in early detection of potential mental health problems, leading to lowering of the disease burden.

INCLUSIVENESS AND EQUAL OPPORTUNITIES
The UEF policy on gender equality and equal opportunities is based on Finnish legislation and the values of the university. The goal of gender equality and equal opportunities at the university is to identify and prevent expressions, structures and functions that maintain or increase inequality and to promote gender equality and equal opportunities at all levels. The university has a Gender Equality and Equal Opportunities Programme, which describes the measures intended to implement and promote gender equality and equal opportunities among staff and students. The university takes an active approach to promoting equal opportunities and acting against discrimination.

UNIVERSITY OF EASTERN FINLAND IN BRIEF
The University of Eastern Finland is the most multidisciplinary university in Finland. We are home to 15,500 students and 2,700 staff members. Our research is ranked among the best in the world in several fields (inc. forest sciences). We generate research-based knowledge and make it openly accessible for the benefit of all. UEF stands for action with impact that is relevant today and tomorrow. To learn more about our university please visit our website at www.uef.fi/en.

Postdoctoral Researcher/Project Researcher, Biomedical NMR – A.I. Virtanen Institute, University of Eastern Finland

27.3.2021 | Ajankohtaista

https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=16&id=000010912&lang=fi#.YFyPbVLuess.link

The University of Eastern Finland is inviting applications for a Postdoctoral Researcher / Project Researcher (Biomedical NMR) position in Kuopio. The position will be filled for a two-year term from 1 May 2021 (or as agreed). Please find more information below and submit your application no later than April 14, 2021.

Role and salary

As our new Postdoctoral or Project Researcher in Biomedical NMR, you will be working in the A.I. Virtanen Institute at the Faculty of Health Sciences, Kuopio Campus.

The Metabolic MRI group at the University of Eastern Finland is aiming to develop hyperpolarisation-based methods for metabolic magnetic resonance imaging. The applicant will be working in a neuroimaging project, aimed to image stroke and other neurological models at high (3T) and low (0.6T) magnetic fields. The project will improve the understanding of the metabolism of hyperpolarised marker molecules (e.g. pyruvate) during stroke and help establish the experimental basis for further development of hyperpolarized low-field MRI. The researcher will join a group currently including 2 PhD students and the Research Director. In addition to collaborations within Finland, the project involves collaborations with research groups in Denmark and Italy.

The successful candidate will hold a suitable doctoral degree. If you have been awarded your doctoral degree less than five years ago, the post will be one of a Postdoctoral Researcher. If the doctoral degree has been awarded more than five years ago, the post will be one of a Project Researcher. In this context, the 5 years refer to a net period time, which does not include maternity leaves, parental leaves, or military service.

The position will be filled for a two-year term from 1 May 2021 (or as agreed). The position will be filled for a fixed term due to it pertaining to a specific project. A probationary period is applied to all new members of the staff.

The salary of the position is determined in accordance with the salary system of the Finnish universities. The salary comprises two components: a job requirement component and a personal performance component. In this position, the job requirement component is 2,967.84 euros/month, based on level 5 of the job requirement chart for teaching and research staff. The personal performance component can be a minimum of 6 % and a maximum of 50 % of the above-mentioned sum.At the beginning the salary will be 3 267,59 – 3 626,70 e.

Our requirements and expectations

– The successful candidate will hold a suitable doctoral degree.
– Good level of fluency in English (both written and spoken) is essential.
– Previous experience in preclinical work with small animal, especially neurosurgery or similar, or MR research is highly preferred, but not essential.

Your benefits

You will have access to the university’s staff benefits, including
– extensive occupational health care
– staff discount on lunch in our campus restaurants, as well as on a range of other services
– affordable sports services.

You will have an opportunity to work in an interesting role as part of our international, creative, participatory and inclusive academic community.

How to apply?

Submit your application by using our electronic application form no later than 14.4.2021 (by 24.00 hours Finnish time).

Please note that you must include the following appendices in your application:

– CV (http://www.tenk.fi/en/template-researchers-curriculum-vitae)
– list of publications (https://www.aka.fi/en/research-funding/apply-for-funding/how-to-apply-for-funding/az-index-of-application-guidelines2/list-of-publications/)
– motivation letter
– copies of your academic degree certificates / diplomas, and copies of certificates / diplomas relating to your language proficiency, if not indicated in the academic degree certificates/diplomas

Questions?

For further information on the position, please contact Research Director Mikko Kettunen, +358 29 4454067, mikko.kettunen@uef.fi

For further information on the application procedure, please contact Human Resources Secretary Sari Zitting, +358 29 4454125, sari.zitting@uef.fi


University of Eastern Finland and the Faculty of Health Sciences in brief

The University of Eastern Finland is the most multidisciplinary university in Finland. We are home to 15,500 students and 2,700 staff members. Our research is ranked among the best in the world in several fields. We generate research-based knowledge and make it openly accessible for the benefit of all. UEF stands for action with impact that is relevant today and tomorrow. To learn more about our university please visit our website at http://www.uef.fi/en     

The Faculty of Health Sciences operates at the Kuopio Campus of the University of Eastern Finland. The Faculty offers education in medicine, dentistry, nutrition and pharmacy, as well as in some other central fields of the health care sector. The Faculty is research-intensive, and its internationally recognised research activities are closely linked to the strategic research areas of the University. There are approximately 3 100 degree students and about 580 PhD students in the Faculty. The faculty has 795 staff members. http://www.uef.fi/en/ttdk/etusivu