Ajankohtaista

Doctoral student, the Faculty of Biochemistry and Molecular Medicine

16.6.2021 | Avoimet työpaikat

https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=1&id=000011601&lang=fi

We are now looking for a motivated Doctoral student in a project addressing the roles and molecular interactions of collagen XIII (ColXIII) in the neuromuscular junction (NMJ).

Description

Applications are invited for a full-time Doctoral student (max. 4 years) position, starting at the earliest on 1.10.2021 in a research project headed by Professor Taina Pihlajaniemi in the Extracellular matrix & Hypoxia Research Unit, operating at the Faculty of Biochemistry and Molecular Medicine. Molecular and environmental basis for lifelong health is one of the strategic focus areas of the University.  The doctoral student is enrolled in the Health and Bioscience Doctoral Programme of the University of Oulu Graduate school, which provides support in theoretical and practical training.

We are now looking for a motivated Doctoral student in a project addressing the roles and molecular interactions of collagen XIII (ColXIII) in the neuromuscular junction (NMJ). Using murine models we have shown that ColXIII is an essential NMJ component and others have recently shown that mutations in the human gene cause congenital myasthenic syndrome type 19 (CMS19). Using mouse and cell culture models we will identify the network of molecules and the events whereby ColXIII operates in the normal NMJ and the developmental events that lead to CMS19. We will also determine the occurrence of anti-ColXIII autoimmune antibodies in patients with acquired generalized and ocular myasthenia gravis and assess their effects on the NMJ. The studies provide unique opportunities to enhance the understanding of critical motor synapse molecules and facilitate personalized therapies in genetic and acquired myasthenia. The position is fixed-term for 4 years in an Academy of Finland-funded project and it targets to completion of a Doctoral thesis and multiple publications in high-ranked international journals. Besides research, the position includes some teaching duties in an international Master’s Programme in Biochemistry.

Qualification requirements

The successful candidate for the Doctoral student position must possess a M.Sc. degree in the field of biochemistry, molecular or cell biology, medical science or related fields. We also invite applications from pre-graduate students from these fields of university studies. In this case, to be eligible for application, the candidate must demonstrate that he/she will graduate at home University not later than 31.12.2021 and also provide 1) an official statement from the home University attesting that all the courses, exams and other qualifications needed for graduation have already been obtained, 2) an official statement from the home University attesting that thesis has been submitted for evaluation and, 3) a letter of support from the candidate’s Supervisor (the minimum acceptable level for supervision is docent / assistant professor).

Prior experience in molecular biology and cell culture-based experiments is required, and proficiency in microscopy is expected. Prior experience in generating or working with experimental mouse models, and knowledge of the research field in question is considered an advantage. Good communication and teamwork skills are appreciated. Fluency in both written and spoken English is required. Most importantly, we expect the candidate to have a high motivation to conduct high-level biomedical research.

What we offer

We offer a research environment with excellent technological facilities and a motivating and supporting international community at the Faculty of Biochemistry and Molecular Medicine, University of Oulu. We can also offer access to state-of-the-art facilities and special expertise through visits to collaborative laboratories outside Oulu when needed. You will have a place in a highly talented research group, working to solve globally significant research problems. University´s wide variety of support services are at disposal, allowing to focus on studies and research work. The position is fixed-term for 4 years as of 1.10.2021 or as soon as possible thereafter. A trial period of 6 months is applied in the position.

Salary

The initial salary for the new Doctoral student will be based on the demand level 2 of the national salary scale for teaching and research personnel of Finnish universities.  In addition, a salary component based on personal work performance will be paid (maximum of 50 % of the job-specific component) and upgraded based on qualification in research work and progress in PhD studies. In practice, the salary of a new doctoral student will be roughly 2300-2500 € / month before taxes. The salary will be evaluated yearly.

How to apply

Applications, together with all relevant enclosures, must be submitted using the electronic application form by August 15, 2021, at 23:59 (Finnish local time, EEST), with the following attachments as three separate pdf files:

1. Complete CV containing contact information of at least two referees (Max. size limit of the attachment: 5 Mbytes)

2. Motivation letter summarizing professional experience and expertise, reasoning interest in this position and describing career plans (1-2 pages; max. size limit of the attachment: 2 Mbytes).

3. Certificates/Diplomas: Scanned electronic copies of diplomas and transcripts of the records of relevant previous degrees. For the candidates who do not yet hold the M.Sc. degree, please provide: 1) an official statement from the home University attesting that the coming graduation date of the candidate is 31.12.2021 at the latest; 2) an official statement from the home University attesting that all the courses, exams and other qualifications needed for graduation have already been obtained; 3) an official statement from the home University attesting that thesis has been submitted for evaluation and, 4) a letter of support from the candidate’s Supervisor (the minimum acceptable level for supervision is docent / assistant professor). (Max. size limit of the attachment: 2 Mbytes)

Only applications containing all relevant appendices and submitted through the online recruitment system will be considered. Top candidates will be invited to an on-site or remote interview. Applications sent by email will not be considered. The eligible applicants fitting best in the research profile expected for the position may be invited to an on-site or remote interview. All applicants will be notified when the selection process is completed.

Further information

For further information, please contact Prof. Taina Pihlajaniemi, e-mail: taina.pihlajaniemi (at) oulu.fi or Dr. Anne Heikkinen; e-mail: anne.heikkinen (at) oulu.fi

Uuden puheenjohtajan terveiset

14.6.2021 | Ajankohtaista

Artikkeli on julkaistu myös Solubiologi-lehden numerossa 1/2021.

Hyvä Suomen Solubiologit ry:n jäsen/seuraaja!

Suomen Solubiologit ry sai helmikuussa uuden hallituksen, ja tällä kertaa myös uuden puheenjohtajan. Elina Siljamäki on luotsannut hallitusta ja koko yhdistystä erittäin ansiokkaasti vuodesta 2013 lähtien, jolloin olin jo itsekin mukana hallituksessa. Tähän saakka olen hoitanut tiedotussihteerin tehtäviä ja seurannut, kuinka hienosti Elina on kehittänyt yhdistyksemme toimintaa. Kuluneisiin vuosiin on mahtunut lukemattomia seminaareja, tapahtumia, kokouksia ja yhdistykselle muitakin tärkeitä merkkipaaluja. Elinan aikana on muun muassa päivitetty yhdistyksen nettisivut, rakennettu jäsenintra ja järjestetty tieteellinen yhteisseminaari Suomen Sidekudostutkijat ry:n kanssa helmikuussa 2020. Toimintaamme seuranneet voivat varmasti olla samaa mieltä siitä, että Elina on tehnyt erittäin hyvää työtä, minkä ansiosta yhdistyksemme on tullut monelle tutuksi. Kiitos siis, Elina, kuluneista vuosista sekä siitä, että saamme pitää sinut hallituksessa mukana!

Olette varmastikin huomanneet, että Suomen Solubiologit on viime vuosina lisännyt näkyvyyttään sosiaalisessa mediassa – meidät löytää nykyään nettisivujen lisäksi myös Facebookista, Instagramista ja Twitteristä. Näin pyrimme tulemaan tutuiksi alan opiskelijoille, työntekijöille, yliopistoille ja erilaisille organisaatioille koko Suomen alueella. Sen perusteella, mitä olen organisaatioviestinnästä oppinut, tärkeää on viestiä juuri siellä, missä tärkeät kohderyhmät viettävät aikaansa. Sen perusteella, että nykyinen hallituslaisemme Terhi Heino löysi meidät alun perin juuri Instagramin kautta, voidaan työn nähdä jo kantavan hedelmää. Toivon, että pystymme kehittämään viestintäämme niin, että voimme tarjota teille jatkossa yhä mielenkiintoisempaa sisältöä, ja että meidät löytänyt henkilö päätyisi tutustumaan toimintaamme tarkemminkin. Suuri yhdistyksen ylpeyden aihe on myös Solubiologi-lehti, jota päätoimittaja Jenny Joutsen on uudistanut viime vuosina toimituskunnan kanssa. Solubiologi on tyylikäs, ajankohtaisia aiheita käsittelevä julkaisu, ja tiettävästi myös ainoa suomen kielellä artikkeleita julkaiseva alan lehti. Tällä tavoin teemme omalta osaltamme työtä tieteen popularisoinnin hyväksi.   

Yksi tärkeä tehtävämme on toimia yhdyssiteenä alan opiskelijoiden ja työelämän välillä. Tämän toteuttamiseksi olemme jo vuosia tiedottaneet alan avoimista työpaikoista nettisivuillamme ja sosiaalisen median kanavissamme. Se on selkeästi ollut tehokasta: hallituslaiset ovat useaan otteeseen kuulleet, että moni on saanut tiedon avoimesta työpaikasta ensin nimenomaan meidän kauttamme. Hienoa on myös se, että rekrytoivat tutkimusryhmät ja yritykset ottavat meihin suoraan yhteyttä ja pyytävät mainostamaan avoinna olevaa työ-, opiskelu- tai harjoittelupaikkaa. Kunniajäsenemme Jari Rantamäen sanoin: Silloin kun yhdistykseen otetaan yhteyttä jonkin asian tiimoilta, niin silloin on tehty jotakin oikein. Tämä on mielestäni konkreettinen osoitus siitä, että todella toimimme molemminpuolisena yhdyssiteenä opiskelijoiden ja jäsentemme sekä työelämän välillä. Yksi tavoitteistani on, että yhdistyksemme keksii tulevaisuudessa muitakin tapoja toteuttaa tätä tehtävää, jolloin voimme omalta osaltamme tukea alan opiskelijoiden ja jäsentemme työllistymistä.

Haluan vielä kerran kiittää kunniasta toimia tämän hienon yhdistyksen puheenjohtajana – lupaan kehittää Suomen Solubiologien toimintaa parhaani mukaan, yhdistyksen arvokkaita perinteitä kuitenkaan unohtamatta!

Kevätterveisin Johanna Matilainen

Postdoctoral Researcher, Population Genomics

14.6.2021 | Avoimet työpaikat

https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=1&id=000011533&lang=fi

A three-year Postdoctoral Researcher position in Population Genomics is available in the Ant Genomics and Immunity group (https://lumiviljakainen.wordpress.com/).

In this project, funded by the Academy of Finland, we will study genetic underpinnings of convergent evolution of multi-queen colonies (polygyny) in ants. We will investigate genomic architecture and selection across the genomes of monogynous and polygynous ant species using whole-genome sequencing. In addition, immune gene evolution will be studied in these ant societies to decipher whether polygynous lineages have followed similar evolutionary trajectories after convergent evolution.

Open position

  • the main duties of the successful candidate are bioinformatics and population genomic analysis of whole-genome sequence data of several ant species and dissemination of research findings
  • other tasks include supervision of Ph.D. and M.Sc. students

Qualification requirements:

  • Ph.D. in biology, obtained less than 10 years ago
  • Experience in population genetics, high-throughput sequence data and bioinformatics
  • Ability to work both independently and in a team, and supervise graduate and undergraduate students
  • Fluency in both written and spoken English

 What we offer

  • We offer you a place in an ambitious research group with excellent international collaborators
  • University´s wide variety of support services are at your disposal, allowing you to focus on your research
  • In addition to modern research facilities, we offer you personnel benefits such as free occupational healthcare, affordable sport services and endless opportunities to develop your skills and competences
  • Regular salary is paid 12 months per year, including paid leave and an additional holiday bonus in the summer
  • The successful candidate will also receive benefits provided by the Finnish government to residents, for example possibility to obtain access to the national healthcare system, tax benefits for employees with children and high-quality, affordable childcare services.

Salary

A salary in accordance with the Finnish universities salary system (for teaching and research personnel): level 5. In addition, a salary component based on personal work performance will be paid (maximum of 50% of the job-specific component). Starting gross salary will be approx. 3500€ per month. A trial period of six months is applied in the position.


How to apply

Applications, together with all relevant enclosures, should be submitted using the electronic application form by 30th of June 2021. The application should be written in English and include the following:

1)     A motivation letter (max. 2 pages) summarizing applicant’s professional experience and expertise and describing why applicant is interested in this position. Also, information on personal research interests, experience and career plan may be provided here

2)     Curriculum vitae (max. 4 pages)

3)     List of publications based on the guidelines of the Academy of Finland: https://www.aka.fi/en/research-funding/apply-for-funding/how-to-apply-for-funding/az-index-of-application-guidelines2/list-of-publications/

4)     Certificates/Diplomas: Scanned copy of the original doctoral degree certificate and transcript of records and, when necessary, official translations to Finnish or English

5)     Contact information of two senior/experienced researchers who may be asked to give a statement on the candidate

Only applications containing all relevant appendices and submitted through the online recruitment system will be considered. Top candidates will be invited to an on-site or remote interview.

Further information

The position is for 3 years starting in September 2021 or as soon as possible thereafter. A trial period of 6 months is applied in the position.

Please contact Dr. Lumi Viljakainen (lumi.viljakainen@oulu.fi) with any questions.

Quality Control (QC) Lab Technician

14.6.2021 | Avoimet työpaikat

https://www.recright.com/careers/en/nanoform-finland-oyj/quality-control-qc-lab-technician-60c3483736c0fe5b898dee96

About Nanoform   

Nanoform is an innovative drug particle engineering and nanotechnology company listed on the Premier-segment of Nasdaq First North Growth Market in Helsinki and Stockholm. Nanoform works together with pharma and biotech partners globally to reduce attrition in clinical trials and enhance their molecules’ formulation performance through its nanoforming services. Leveraging our in-house developed AI engine Starmap® we can also predict which customer molecules show most promise for our technology. Nanoform’s capabilities include GMP manufacturing, and its services span the small to large molecule development space with a focus on solving key issues in drug solubility and bioavailability and on enabling novel drug delivery applications.     

Quality Control (QC) Lab Technician  

With the view of developing our organization further, we are now seeking Quality Control Lab Technician to support our quality control team. The position requires availability to integrate shift work regime. The job is located at our facilities in Helsinki, Finland.   

You will be responsible for    

  • Ensure that all QC analysis are carried out in an effective and accurate manner according to company standard procedures (SOPs). 
  • Implement and develop new methods.
  • Maintain and calibrate laboratory equipment.
  • Manage reagent, material, and standards stock levels to ensure lab work continuity.
  • Ensure that records are done in an accurate manner as per company standards and procedures.
  • Support the GMP laboratory activities as per company standard procedures and Quality system. 
  • Support current R&D projects by running appropriate analysis and sampling.
  • Maintain QC Databases and others relevant for QC operations
  • Communicate efficiently with the production and technical teams to discuss QC outcomes and improvements

Ideal experience     

  • You have a Bsc or Msc degree in pharmacy, chemistry, microbiology, biotechnology or in an equivalent field. 
  • You have been working with biomolecules (especially with proteins).
  • Experience from some of the analytical techniques: SDS-PAGE, HPLC-(SEC), immunoassays, DLS.
  • Working knowledge of SOPs, Pharmacopeias and GXP Regulations.
  • Good technical knowledge and understanding of laboratory procedures, methodology and standards.
  • Capacity to work independently in a laboratory environment 
  • Capacity to produce clear records and data reports.
  • Experience in working in GXP environments. 
  • Preferred experience in using electronic Quality systems (LIMS, QMS, CDS, CAPA, others).  
  • You are used to work with MS Office programs.

Personal qualities we are looking for 

  • You are a doer and have an accurate working style 
  • You are flexible in working in a team as well as independently 
  • You have an ability to work in a high-performance environment 
  • Good English level, both written and spoken   

What we offer to you  

  • A great team to join with skilled and highly motivated colleagues
  • Encouraging and forward-looking team spirit
  • You will be part of a team that invents world-class solutions for the pharmaceutical industry
  • We provide extensive learning opportunities. You are able to utilize your skills and competencies widely as we continuously create something new
  • We like challenges and want everyone to enjoy solving them together
  • Competitive compensation package with broad employee benefits selection

You will get to be part of a unique start-up in the pharma industry.   

Interested?   

To apply for this position, please supply a covering letter and CV by 21st of June, 2021. Please note that we may already start the interviewing process during application period.   

Quality Control Lab Technician

14.6.2021 | Avoimet työpaikat

https://www.recright.com/careers/en/nanoform-finland-oyj/quality-control-lab-technician-60c35a7336c0fea0d68df604

About Nanoform 

Nanoform is an innovative drug particle engineering and nanotechnology company listed on the Premier-segment of Nasdaq First North Growth Market in Helsinki and Stockholm. Nanoform works together with pharma and biotech partners globally to reduce attrition in clinical trials and enhance their molecules’ formulation performance through its nanoforming services. Leveraging our in-house developed AI engine Starmap® we can also predict which customer molecules show most promise for our technology. Nanoform’s capabilities include GMP manufacturing, and its services span the small to large molecule development space with a focus on solving key issues in drug solubility and bioavailability and on enabling novel drug delivery applications.   

Quality Control (QC) Lab Technician  

With the view of developing our organization further, we are now seeking Quality Control Lab Technician to support our quality control team. The position requires availability to integrate shift work regime. The job is located at our facilities in Helsinki, Finland.   

 You will be responsible for    

  • Ensure that all QC analysis are carried out in an effective and accurate manner according to company standard procedures (SOPs). 
  • Implement and develop new methods.
  • Maintain and calibrate laboratory equipment.
  • Manage reagent, material, and standards stock levels to ensure lab work  continuity.
  • Ensure that records are done in an accurate manner as per company standards and procedures.
  • Support the GMP laboratory activities as per company standard procedures and Quality system. 
  • Support current R&D projects by running appropriate analysis and sampling.
  • Maintain QC Databases and others relevant for QC operations
  • Communicate efficiently with the production and technical teams to discuss QC outcomes and improvements 

Ideal experience     

  • You have a Bsc or Msc degree in pharmacy, chemistry, microbiology, biotechnology or in an equivalent field. 
  • Working knowledge of SOPs, Pharmacopeias and GXP Regulations.
  • Good technical knowledge and understanding of laboratory procedures, methodology and standards.
  • Experience in all or some of the following analytical techniques: HPLC, UPLC, DSC, XRPD, Laser Diffraction, DLS, Karl Fisher, FTIR, SEM, AFM.
  • Capacity to work independently in a laboratory environment 
  • Capacity to produce clear records and data reports.
  • Experience in working in GXP environments. 
  • Preferred experience in using electronic Quality systems (LIMS, QMS, CDS, CAPA, others).  
  • You are used to work with MS Office programs.

Personal qualities we are looking for 

  • You are a doer and have an accurate working style 
  • You are flexible in working in a team as well as independently 
  • You have an ability to work in a high-performance environment 
  • Good English level, both written and spoken   

What we offer to you  

  • A great team to join with skilled and highly motivated colleagues
  • Encouraging and forward-looking team spirit
  • You will be part of a team that invents world-class solutions for the pharmaceutical industry
  • We provide extensive learning opportunities. You are able to utilize your skills and competencies widely as we continuously create something new
  • We like challenges and want everyone to enjoy solving them together
  • Competitive compensation package with broad employee benefits selection

You will get to be part of a unique start-up in the pharma industry.     

We are looking forward to hear from you!

To apply for this position, please supply a covering letter by 21st of June,2021.

Please note that we may already start the interviewing process during application period.   

Early Stage Researcher, Molecular Biology

14.6.2021 | Avoimet työpaikat

https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=16&id=000011543&lang=fi

The University of Eastern Finland is inviting applications for an Early Stage Researcher in Molecular Biology – position in Joensuu campus. The position will be filled for a period of four year starting from September 1, 2021. Please find more information below and submit your application no later than 3 August 2021. 

Role and salary

The research project, funded by the Academy of Finland, aims to understand the processing of stalled mitochondrial DNA (mtDNA) replication forks, their relation to mtDNA integrity and cellular signalling responses. The PhD student will investigate the role of two proteins in the cleavage of stalled mitochondrial replication forks, the fate of broken mtDNA in cells and the signalling pathways that react to mtDNA damage or interact with extramitochondrial mtDNA.

Positions of Early Stage Researchers shall always be filled for a fixed term (UEF University Regulations, Section 31). The position will be filled for a period of four year starting from September 1, 2021. A probationary period is applied to all new members of the staff.

The salary of the position is based on the salary system for the teaching and research staff at universities. The salary consists of the job-related salary element and the personal performance salary element. For this position, the job requirement level used to determine the job-related salary element is 2–4, and the personal performance salary element is 6–50% of the job-related salary element. The estimated monthly salary in the beginning of the employment will be 2,288.17- 3,163.95 €/per month. The salary of an early stage researcher depends on the phase of the doctoral dissertation and postgraduate studies as well as personal performance.

As Early Stage researcher your main responsibilities will include:

  • Manipulation of enzymes involved in mtDNA maintenance using siRNA knockdown, CRISPR/Cas9-knockout and induced overexpression in cultured cells
  • Analysis of mtDNA replication intermediates and stalled replication forks using agarose electrophoresis and transmission electron microscopy
  • Investigation of the signalling pathways affected by mtDNA damage or mtDNA escape from mitochondria by Western blots, inhibitors and knockdown of key components
  • Research visits to collaboration laboratories
  • Presenting of research results in international conferences and publishing results
  • Writing of a Ph.D. thesis

Our requirements and expectations

A person to be appointed as an Early Stage Researcher shall be qualified to pursue postgraduate studies, i.e. he or she is required to have completed a suitable higher university degree or an equivalent education abroad, which in the country in question would qualify the person for similar academic studies. A master’s degree or equivalent in molecular biology, cell biology, biochemistry or a related field is required for the position. Persons graduating in the near future are also encouraged to apply. However, they are expected to hold a relevant M.Sc. degree (or equivalent) by the starting date of the Early Stage Researcher position.

Potential candidate should have good command of the English language. We expect the student to have good prior knowledge of molecular biology methods and cell culture. Previous experience with mitochondria or mitochondrial DNA metabolism is a plus.

Your benefits
You will have access to the university’s staff benefits, including

  • extensive occupational health care
  • staff discount on lunch in our campus restaurants, as well as on a range of other services
  • affordable sports services. 

Please read more in the Work at UEF section on our website.

You will have an opportunity to work in an interesting role as part of our international, creative, participatory and inclusive academic community.

How to apply?

Submit your application by using our electronic application form no later than 3 August 2021 (by 24.00 hours Finnish time)

Please note that you must include the following appendices in your application:

  • CV (max 2 pages http://www.tenk.fi/en/template-researchers-curriculum-vitae including possible publications)
  • a motivational letter and the contact details for one or two references
  • copies of your academic degree certificates / diplomas, and copies of certificates / diplomas relating to your language proficiency, if not indicated in the academic degree certificates/diplomas 

Questions?

For further information on the position, please contact Senior Researcher Jaakko Pohjoismäki, Ph.D., tel. +358 29 445 3052, jaakko.pohjoismaki@uef.fi.

For further information on the application procedure, please contact Executive Assistant Satu Turunen, tel. +358 29 445 3031, satu.turunen@uef.fi (on vacation July 3- July 30). 

Post-doc­to­ral re­searc­hers and/​or PhD-stu­dents in cell bio­lo­gy and stem cell bio­lo­gy

14.6.2021 | Avoimet työpaikat

https://www2.helsinki.fi/fi/avoimet-tyopaikat/post-doctoral-researchers-andor-phd-students-in-cell-biology-and-stem-cell-biology

The HiLIFE – Institute of Biotechnology (BI), located in the Viikki science park, is a research institute at University of Helsinki. The institute harbors ~35 research groups and 250 researchers, and it operates at the highest international level. For more information on the Institute, please visit https://www.helsinki.fi/en/hilife-institute-of-biotechnology.

The laboratory of Dr. Jette Lengefeld is inviting applications for post-doctoral researchers and/or PhD-students in cell biology and stem cell biology.

The failure to regenerate tissue with age is a major health issue. A contributor to this decline is the loss of stem cell function. Despite the essential role of stem cells, it is still unclear how they fail to maintain their functions during ageing and disease. We discovered a new aspect of stem cell ageing in vivo: cellular enlargement. With age and damage, stem cells increase in size causing their functional decline. However, we are only beginning to understand how size impacts stem cell fitness and the physiological importance of this process remains unsolved.

The Lengefeld research group uses blood (hematopoietic) stem cells from mice and human bone marrow donations to address these fascinating questions:

  • What pathways cause stem cell dysfunction during their enlargement?
    We use blood (hematopoietic) stem cells of mouse models to identify the molecular mechanisms impairing fitness of large stem cells from a metabolic perspective.
  • Can we rejuvenate stem cells after aging and damage?
    We explore approaches to rejuvenate stem cells and investigate the effects on cellular ageing and organismal health.
  • Does deregulation of size lead to cancer?
    We utilize blood stem cells from mice and humans to identify factors that facilitate leukaemia in vivo and to investigate the underlying mechanisms.

The post-doctoral applicants should hold PhD in cell biology, stem cell biology, cell size regulation or a related field. Strong expertise in stem cell biology and experience working with mice is highly beneficial. The PhD-student applicants should obtain MSc or related degree in the biology field latest by August 2022, and have a strong interest to carry out cutting-edge research. The positions will provide multiple opportunities for collaborations with potential lab visits abroad. An attitude to drive own research and work in an intra and inter team fashion is highly appreciated. In return, the candidates are offered an access to a wide variety of methodologies and advanced techniques. The working language of the laboratory, the BI and HiLIFE is English and good communication skills in English are required.

The postdoctoral researcher and PhD-student positions are initially limited to 2 and 4 years, respectively, with a possibility of extension. A trial period of 6 months will be applied, and the salaries will be based on the University salary scheme for teaching and research personnel composed of both task specific and personal performance components.

Application should include the following documents as a single pdf file: CV, list of publications, motivation letter including a description of your research interests, and the names and telephone numbers of at least two referees.

Please submit your application, together with the required attachments, through the University of Helsinki electronic recruitment system by clicking the “Apply for the position” – link below. Applicants employed by the University of Helsinki must submit their application through the SAP HR portal.

The deadline for the applications is 8th of July 2021, but the positions will be filled immediately once suitable candidates have been identified.

For informal inquiries, contact ‘jette.lengefeld(at)helsinki.fi’, and for more information about our research, please visit https://www2.helsinki.fi/en/hilife-institute-of-biotechnology/research/c…

For technical support regarding the recruitment system, please contact rekrytointi@helsinki.fi.

Research and Senior Scientists, Protein Production (Fixed-term)

1.6.2021 | Avoimet työpaikat

https://tyopaikat.loimu.fi/tyopaikat/?kategoria0=Kemia%20ja%20life%20science&sivu=1

Do you want to join us to develop new biotechnology and microbial systems for protein production?

We are looking for ambitious and customer-oriented Research Scientist and Senior Scientist (two positions) with a background inprotein production systems and fungal biology.

As a researcher at our Protein Production Team, you will have a key role and an opportunity to work on topics of great importance to society such as production of sustainable, animal free food proteins, production of vaccines to reduce antibiotics use in animals, enzyme mixtures for biofuel production, and therapeutic proteins for human medicine. You have the opportunity to work together with different customers ranging from big companies to start-ups and to support them in solving challenges with the help of science and technology.

Read more about our work in the following articles:

Eggs without chickens, milk without cows?

New fungal production platform C1 for vaccines and therapeutic proteins

With us you will be responsible for

  • Scientific project work in the fields of protein production systems and fungal biology
  • Writing scientific reports and presenting research data
  • Working with customers to help them solve challenges 

We expect you to have

  • Completed MSc or PhD in relevant field
  • Excellent laboratory skills and experience in molecular biology techniques
  • Experience working with yeast or filamentous fungi
  • Strong spoken and written English skills

As you person you are

  • Motivated and willing to take initiative in getting projects accomplished
  • You have strong communication skills
  • Able to work both independently and as a member of a team
  • Curious towards various scientific and technological challenges
  • Willing to travel to customer and scientific meetings 

We offer

At VTT, we believe that our impact is built on scientific and technological excellence in all our work. Our personnel are at the core of VTT, where wellbeing and competence development are key priorities. You will be a part of a creative and international working environment. The tasks are versatile, independent and challenging, with support and coaching where needed.

We offer this excellent opportunity to work with an experienced research team to better understand and develop fungal protein production hosts used for production of proteins and enzymes used in food, feed, biofuels, animal care, textiles, and human medicine.

Further information

For more information about the position, you can contact Chris Landowski, Research Team Leader, Protein Production, christopher.landowski@vtt.fi

These are two years fixed-term positions.

You can find more information about the team and the projects:

VTT Finland-Protein Production Team

VTT develops piglet vaccination to reduce antibiotics use

We are looking forward to hearing from you, so please send your CV and application as soon as possible, or June 16th at the latest!

Postdoctoral Researcher, MindGAP, Faculty of Biochemistry and Molecular Medicine

1.6.2021 | Avoimet työpaikat

https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=1&id=000011427&lang=fi

We are now looking for a Postdoctoral Researcher to join our multidisciplinary FET OPEN EU consortium project “MindGAP”

Research description

The MindGAP project centers around the hypothesis that brain-derived extracellular vesicles (EVs) present in blood can have a positive effect on disease outcomes (https://mindgap-fet-open.eu/home).

MindGAP WP3 is aiming to identify and characterize CNS EV markers targeting them to blood and to identify biomarkers of successful mindfulness in cancer survivors for the development of microfluidic testing device.

The MindGAP project work involves such tasks as EV isolation from biofluids and primary human neural cell cultures, characterization of EV surface proteome, RNA cargo analysis, mindfulness biomarker identification and validation. These studies are performed in collaboration with the rest of the FET OPEN consortia in Sweden, Portugal, and Finland (VTT).

Open position

We are looking for a candidate with expertise in biochemistry, biomarker identification and validation, strong molecular biology background, and experience with liquid biopsy/biofluids or EV research.

The selected applicant will perform hands-on experiments in the laboratory, participate in relevant seminars and lectures, write research documentation and reports, and perform teaching duties at the Oulu University Faculty of Biochemistry and Molecular Medicine.

The position is a fixed term contract for one year. The selected applicant is expected to apply for personal funding to advance their research career.

Required qualifications

  • The applicant must have a PhD degree in life sciences, at the commencement of the position, that was awarded a maximum of four years ago.
  • Applicants should have a degree in molecular biology, biochemistry, or a related field.
  • Doctoral students whose PhD thesis will be submitted by the application deadline are eligible to apply.
  • An ability to pursue independent research, work productively in a team, and supervise younger scientists are necessary.
  • The candidate should have good written and verbal English skills.
  • The successful candidate is expected to have strong expertise in membrane protein isolation and analysis (mass spec sample preparation and analysis), protein chemistry, molecular biology. Experience in medium-throughput protein and nucleic acid biomarker assays, along with liquid biopsy, EV analysis, bioinformatics, and preparation of primary neural cell cultures from human biopsies will be advantageous.

What we offer

  • We offer you a place in a highly talented research group, working to solve globally significant research problems.
  • In addition to modern research facilities, we offer you personnel benefits such as free occupational healthcare, affordable sport services and endless opportunities to develop your skills and competences.
  • Regular salary is paid 12 months per year, including paid leave and an additional holiday bonus in the summer.
  • The successful candidate will receive also benefits provided by the Finnish government to residents, for example possibility to obtain access to the national healthcare system, tax benefits for employees with children and high-quality, affordable childcare services.

Salary

A salary in accordance with the Finnish universities salary system (for teaching and research personnel): level 5. In addition, a salary component based on personal work performance will be paid (maximum of 50% of the job-specific component). Starting gross salary will be approx. €3100 € per month.

How to apply

Applications, together with all relevant enclosures, should be submitted using the electronic application form by 04.06.2021. The application should be written in English and include the following:

1)        A motivation letter describing prior knowledge on the subject matter and personal research interests with career plans (max. 2 pages)
2)        Complete CV containing contact information of at least two references
3)        List of publications 
4)        Certificates/Diplomas: Scanned copies of relevant degree certificates must be included. If the original documents are not in English, Finnish or Swedish, each document must be accompanied by an official certified translation into English or Finnish

Only applications submitted through the online recruitment system with the required attachments will be considered. Top candidates will be invited to an online interview.

Further information

The position is fixed term for maximum of one year as of August 1, 2021 or as soon as possible thereafter. A trial period of 6 months is applied to the position.

For additional information, please contact

Project leader Dr. Genevieve Bart, Adj. Professor, e-mail: genevieve.bart(at)oulu.fi 
Principal Investigator Dr. Seppo Vainio, Professor, e-mail: seppo.vainio(at)oulu.fi 

Senior Scientist In Vivo, neuropsychiatry

1.6.2021 | Avoimet työpaikat

https://jobs.criver.com/job/Kuopio-Senior-Scientist-In-Vivo%2C-neuropsychiatry-70210/747497900/

For over 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

IMPORTANT:   In order to be considered for this position, a resume/CV must be uploaded and submitted during the application process.  Please make sure work history and education are added correctly.

Job Summary

We are looking for an organized, proactive and self-driven individual to join our Discovery Neuroscience Scientific Team at Charles River Laboratories in Kuopio, Finland. 

Responsibilities

The person in this role will be expected to operate in a highly collaborative environment, partnering with peers, operational teams at the site and at other locations and work closely with Clients. 
The position requires proven track of experience in preclinical in vivo models for neuropsychiatry and/or addiction and expertise in in vivo pharmacological studies. 
The candidate will be part of a multi-disciplinary preclinical research team and will report to Principal Scientist In Vivo.
In this position you will be leading Client projects in CNS drug discovery field ensuring the scientific excellence of study design, execution, data analysis and reporting. 
The candidate will help to set program/study strategies and provide steps forward based on the outcomes.
In addition to Client studies, you will be involved in R&D activities including validations of new assays, models, and techniques to support capabilities portfolio of the Company and specific Client’s needs.

Job Qualifications

Education 

  • MSc with 7+ year of relevant experience or PhD degree (Neuroscience/Pharmacology) with 2+ years of relevant experience with a focus on preclinical in vivo psychiatry/mood disorder assay and models is required

Experience Required

  • Experience in pharmaceutical industry and/or preclinical contract research organization and /or post-doctoral experience in academia will be an asset
  • Proven expertise and hands-on experience in developing, and validating animal models and assays in psychiatry area utilizing an array of in vivo endpoints such us behavioral testing platforms, etc. is required
  • Understanding translational aspect of rodent models of major depressive disorder, autism, schizophrenia, psychosis, anxiety etc is required
  • Previous experience in utilizing in vivo models of neurological diseases in pharmacological studies is required 
  • Proven expertise and hands-on experience in in vivo models of drug abuse and addiction is an asset
  • Solid understanding of preclinical stages of drug discovery process 
  • Proven ability to work in a team in collaboration-based environment
  • Strong track record of independent scientific leadership and strategic impact, as evidenced by delivery of numerous project milestones, publications etc. 
  • A dynamic, can-do attitude and a flexible approach to problem solving. Sound scientific judgement which has impacted on the direction and delivery of projects or departmental initiatives
  • Ability to lead, coordinate and prioritize and get things done
  • Excellent analytical, organizational and communication skills
  • Ability to work flexibly across projects and adapt to new priorities in fast-paced environment
  • Fluent spoken and written English, scientific writing skills 

About Discovery
Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 320 patents and 74 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.

About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.

With over 18,000 employees within 100 facilities in 24 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2019, revenue increased to $2.62 billion.

At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of 85% of the drugs approved by the FDA in 2019.
 

For more information, please visit www.criver.com.