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Blueprint Genetics is looking for a Geneticist (Clinical Interpretation, Helsinki)

9.4.2019 | Avoimet työpaikat

Introduction
Blueprint Genetics is on a mission to bring world-class genetic knowledge to mainstream healthcare. To meet the challenges imposed by our rapid growth, we are looking for new Geneticists to join our Clinical Interpretation Team. We are a team of experienced professionals with diverse backgrounds who share the passion for helping patients and families suffering from inherited disorders. Our constantly evolving diagnostic portfolio currently includes over 200 tests that cover a wide variety of clinical specialties and diagnostic approaches, including Whole Exome Sequencing. We work with hundreds of clinics around the globe and the quality of our interpretation has been praised by many of the world’s best medical centers. If you have the ambition to be among the pioneers of the molecular era of medicine, you might be the person we are looking for.

Job description
The position involves interpretation and reporting of findings from our clinical molecular genetic tests, including panel-based tests, Whole Exome Sequencing and targeted variant tests. Our Geneticists also participate in the development and validation of products and applications in a project team environment. Those interested get to collaborate with our Software Engineers and Data Scientists with the development of our proprietary software tools that enable us to interpret identified variants efficiently by utilizing artificial intelligence and machine learning.

The ideal candidate has:

  • Clinical Laboratory Geneticist degree or Board certification in Clinical Molecular Genetics / Laboratory Genetics and Genomics or Ph.D. in Genetics.
  • Experience in interpreting and reporting genetic test results in a clinical setting utilizing NGS, Sanger sequencing and other methods is an asset, but similar research experience is valued as well.
  • Knowledge of current genomic information and variant databases is essential
  • Fluent skills in oral and written English are a necessity
  • Great attention to detail
  • Critical thinking when reviewing scientific literature
  • Effective planning and organization skills
  • Excellent follow-through abilities
  • Experience in working under certified and accredited quality management systems is an asset.
  • Fitting the immediate, low-hierarchy and positive Blueprint culture

What we offer
At Blueprint Genetics, you get to be a valued part of our global and multidisciplinary team of people who want to make a difference. You will be working daily to bring your expertise from base pairs to bedside for improved patient outcomes. We offer you a rapidly evolving working environment where you can learn and grow together with a unique company and great colleagues. You get to use everything you have learned in an environment that is unlike anything you have experienced before.

The position is permanent full-time position.

More information and application at https://careers.blueprintgenetics.com/jobs/212558-geneticist

Research programs unit at the University of Helsnki has an open position for a BIOINFORMATICIAN in an exciting collaboration discovering pathways and targets for neurodegenerative diseases

9.4.2019 | Avoimet työpaikat

The Faculty of Medicine promotes scientific research of a high standard and is responsible for providing research-based undergraduate and postgraduate education in medicine, dentistry, psychology and logopedics, as well as for the English-language Master’s Programme in Translational Medicine. In addition to its teaching and research activities, the Faculty serves as a significant expert organisation in the healthcare sector and contributes to the discourse on ethics in the field. In terms of research, the Faculty aims for a place among the best medical faculties in the world, while consolidating and strengthening its status as a top-level institution of medical education.

Together with the Helsinki University Hospital (HUS) and the Helsinki Institute of Life Sciences (HiLIFE), the Faculty of Medicine, University of Helsinki, constitutes the Academic Medical Center Helsinki (AMCH). This medical center has been very successful in international comparisons, ranking among the top 10 medical campuses in Europe and among the top 50 globally.

Research Programs Unit of the Faculty of Medicine is a top-quality research environment. Unit’s nine research programs comprises groups that integrate clinical, translational and biomedical research.

Research programs unit has an open position for a BIOINFORMATICIAN  in an exciting collaboration discovering pathways and targets for neurodegenerative diseases. We search for an experienced bioinformatician highly motivated to participate in an early-discovery NeurOmics project, belonging to a novel pharma-academia “New Modalities Ecosystem”.

More information and application at https://www.helsinki.fi/en/open-positions/bioinformatician

A post-doctoral fellow in Thyroid Research at the Institute of Biomedicine, University of Turku, Turku, Finland

8.4.2019 | Avoimet työpaikat

Post-doctoral job is available at the Research Centre for Integrative Physiology and Pharmacology, In Docent Jukka Kero´s Thyroid group at the Institute of Biomedicine, University of Turku, Finland. The Department is well equipped with facilities for modern molecular and cell biology research. The close connection with Turku Center for Disease Modeling (TCDM) offers excellent facilities and infrastructure to perform experiments with genetically modified disease models.

We are looking for a highly motivated senior researcher or a postdoc with strong experience in molecular biology, genetics and experimental disease models. The group focuses on molecular mechanisms of thyroid disorders. We are studying thyroid genetics in patients with congenital or hereditary thyroid diseases using in silico, in vitro methods, or genetically modified disease models.

The research project focuses on novel gene mutations and testing their pathogenicity in vitro and in vivo. The work involves analyzing the next-generation sequencing data and generation and phenotyping of new disease models. The researcher will work closely with technicians and PhD-students in the group.

There is a trial period of four (4) months. The position is for 2-4 years and could start in May 2019 or as negotiated.

For more information, please contact Jukka.Kero@utu.fi .

Post-doctoral position in the group of Inari Kursula at the Faculty of Biochemistry and Molecular Medicine & Biocenter Oulu, University of Oulu, Finland

5.4.2019 | Avoimet työpaikat

We have an opening for an enthusiastic post-doctoral fellow to study the molecular mechanisms governing actin polymerization, ATP hydrolysis, phosphate release, and filament stability in malaria parasite actins. The successful candidate has a keen interest to understand cytoskeletal proteins and cell motility in depth. A strong background in protein biochemistry and X-ray crystallography is required. Expertise in cryo-EM sample preparation and structure determination will be highly valued. In addition, a high level of own initiative and the ability to work in a team and supervise younger scientists are necessary.

The Faculty of Biochemistry and Molecular Medicine (FBMM; https://www.oulu.fi/fbmm/) is a dynamic and international working place, where the working language is English. Protein science is one of the focal areas of the Faculty. FBMM provides cutting-edge research facilities for molecular biology, protein biochemistry, X-ray crystallography, and light and electron microscopy. In addition, we have generous access to several large-scale facilities for structural biology (MX/SAXS/cryo-EM).

Funding is initially available for 2.5 years, but there may be possibilities for an extension. The starting date should be as soon as possible.

Applications and informal enquiries should be sent by e-mail to inari.kursula@oulu.fi.

Applications should contain

(i)                  a cover letter detailing your specific interest in this project and your key skills and expertise,

(ii)                a CV including a list of publications, and

(iii)             contact information (e-mail) for 3 referees.


Applications should preferably be sent by 30.4.2019, but screening of candidates will continue until a suitable one has been identified.

For more information on our work, please visit our website: http://cc.oulu.fi/~inkursul/lab

Some recent publications directly relevant for the topic:

Kumpula EP, Lopez AJ, Tajedin L, Han H & Kursula I (2018) Atomic view into Plasmodium actin polymerization, ATP hydrolysis, and phosphate release. bioRxiv: 467423, https://doi.org/10.1101/467423.

Kumpula EP, Pires IP, Lasiwa D, Piirainen H, Bergmann U, Vahokoski J & Kursula I (2017) Apicomplexan actin polymerization depends on nucleation. Sci Rep 7: 12137.

Pospich S, Kumpula EP, von der Ecken J, Vahokoski J, Kursula I & Raunser S (2017) Near-atomic structure of jasplakinolide-stabilized malaria parasite F-actin reveals the structural basis of filament instability. Proc Natl Acad Sci 114: 10636-10641.

Green JL, Wall RJ, Vahokoski J, Yusuf NA, Ridzuan MAM, Stanway RR, Stock J, Knuepfer E, Brady D, Martin SR, Howell SA, Pires IP, Moon RW, Molloy JE, Kursula I, Tewari R & Holder AA (2017) Compositional and expression analyses of the glideosome during the Plasmodium life cycle reveal an additional myosin light chain required for maximum motility. J Biol Chem 292: 17857-17875.

For a full list of publications from our group, see: http://cc.oulu.fi/~inkursul/lab/Molecular_mechanisms_of_actin-based_motility/publications.html 

Post-doc position at the University of Pennsylvania / development & regeneration

3.4.2019 | Avoimet työpaikat

Postdoctoral position in skin appendage development and regeneration – Departments of Genetics and Dermatology, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA USA

The Kamberov lab is seeking a candidate to fill a post-doctoral position in skin appendage development and regeneration. The relevant project will focus on investigating the signaling networks that control mammary and sweat gland development, functionality and evolutionary variation. A major goal of this project is to regenerate these organs in vitro. Experimental approaches to be used include generation, analysis and validation of large-scale transcriptomic data from the skin, functional testing and modeling in mice and in vitro organoid culture. The position provides an exciting opportunity to work at the interface of basic and translational research in a highly collaborative environment and gain experience in approaches at the cutting edge of developmental and regenerative biology.

Interested applicants should send a CV, contact information of three references and a letter detailing your interest in the position and lab to Yana Kamberov (yana2@pennmedicine.upenn.edu). Applicants should hold a Ph.D. in biology or related field. Applicants with a strong background in molecular biology, mouse genetics, developmental biology and/or bioinformatics are encouraged to apply.

https://www.kamberovlab.com/

Postdoctoral Researcher (Bioinformatics / Neurosciences), University of Eastern Finland

3.4.2019 | Avoimet työpaikat

The University of Eastern Finland, Faculty of Health Sciences, A.I. Virtanen Institute of Molecular Sciences, invites applications for a Postdoctoral Researcher (Bioinformatics / Neurosciences).

The Kanninen research group is seeking a motivated and experienced postdoctoral researcher to join a highly dynamic group of neuroscientists working on Alzheimer’s disease. The group utilizes in vitro cultures of brain cells to investigate molecular and cellular mechanisms of neurodegeneration. More details on research interests can be found at https://www.uef.fi/en/web/aivi/katja-kanninen-group
 

In this position the candidate should have a PhD in computer science, bioinformatics, biostatistics, neuroscience or related discipline. Experience with various statistical methods is required and the successful candidate should be proficient in using the R programming language. The candidate should be committed and motivated, display independent thinking skills, and possess the ability to work independently while supervising students. Good knowledge of written and spoken English are essential.


The application deadline is 16/04/2019 and the position is filled for a fixed term from 1st of May in 2019 (or as agreed) to 30th of April in 2020. The position is filled for a fixed term due to the duration of the project.  More details at https://www.uef.fi/en/web/guest/uef/en-open-positions

For further information on the position, please contact: Group Leader, PhD, Associate Professor (tenure track), Academy Researcher Katja Kanninen, +358 29 4454202,katja.kanninen@uef.fi

For further information on the application procedure, please contact HR Secretary Asta Suhonen, tel. +358 29 4454125, asta.suhonen@uef.fi.

Cancer Cell Biology group at the University of Helsinki is seeking outstanding candidates for postdoctoral researcher

2.4.2019 | Avoimet työpaikat

The Faculty of Medicine promotes scientific research of a high standard and is responsible for providing research-based undergraduate and postgraduate education in medicine, dentistry, psychology and logopedics, as well as for the English-language Master’s Programme in Translational Medicine. In addition to its teaching and research activities, the Faculty serves as a significant expert organisation in the healthcare sector and contributes to the discourse on ethics in the field. In terms of research, the Faculty aims for a place among the best medical faculties in the world, while consolidating and strengthening its status as a top-level institution of medical education.

Together with the Helsinki University Hospital (HUS) and the Helsinki Institute of Life Sciences (HiLIFE), the Faculty of Medicine, University of Helsinki, constitutes the Academic Medical Center Helsinki (AMCH). This medical center has been very successful in international comparisons, ranking among the top 10 medical campuses in Europe and among the top 50 globally.

Research Programs Unit of the Faculty of Medicine is a top-quality research environment. Unit’s nine research programs comprises groups that integrate clinical, translational and biomedical research.

Cancer Cell Biology group led by Professor Päivi Ojala (https://www.helsinki.fi/en/researchgroups/cancer-cell-biology) at the Translational Cancer Medicine Research Program (CAN-PRO), Faculty of Medicine, University of Helsinki, is seeking outstanding candidates for 

POSTDOCTORAL RESEARCHER

The open positions are in the fields of cancer cell biology and/or virus-host interactions in a project funded by Academy of Finland.

Our research is focused to study the role of lymphatic endothelium in the tumor microenvironment and cancer metastasis. We are interested in the changes in the tumorigenic properties of the cancer cells upon contact with the lymphatic endothelium, (Pekkonen et al, eLife 2018; PMID:29712618) and also in the changes induced in the lymphatics by the tumor cells. In the virus-host interaction studies we are using Kaposi sarcoma herpesvirus (KSHV), an oncogenic human gamma-2 herpesvirus, as a model system to study cancer development and progression (Gramolelli et al, Sci Rep 2018; PMID:29934628). Ultimately, our studies aim to provide mechanistic insights into both improving existing clinical regimens and in identifying novels targets for therapeutic intervention.

We are looking for highly motivated post-doctoral fellows who have successfully completed a PhD in a field relevant to the molecular and cellular biology of cancer and/or virology and published at least one peer-reviewed article in a Pubmed-indexed journal. Experience in mammalian cell culture, cell and molecular biology, as well as microscopy techniques are required. Candidates with demonstrated skills and prior experience in the analysis of NGS datasets and/or mouse tumor models as well as proven track record in terms of publications will be given preference.

Initial contract of employment will be done until the end of 2020 and starting as soon as possible. The contract of employment includes a probationary period of 6 months. Salary will be based on the Universities salary scheme for teaching and research personnel composed of both task specific and personal performance components. 

The application should be in form of a single-pdf containing a one-page cover letter describing your areas of expertise and motivation for the position, recent CV with a publication list, and names and contact information of two to three references.

The application, together with the required attachments, must be submitted through the University of Helsinki electronic recruitment system by clicking on Apply for job. Internal applicants (i.e., current employees of the University of Helsinki) must submit their applications through the SAP HR portal.

Application at https://www.helsinki.fi/fi/avoimet-tyopaikat/postdoctoral-researcher . Apply at latest 10.04.2019.

Further information is available from Professor Päivi Ojala: paivi.ojala(at)helsinki.fi.

Postdoctoral Researcher in Vascular/Cancer Biology at the University of Helsinki

2.4.2019 | Avoimet työpaikat

The University of Helsinki is an international scientific community of 40,000 students and researchers, and ranks among the top 100 international universities in the world.

Research Programs Unit (RPU) of the Faculty of Medicine, University of Helsinki (https://www.helsinki.fi/en/faculty-of-medicine/research-programs-unit) consolidates demonstrated research excellence, with nine focused research programs combining clinical, translational and biomedical research. 

The group of Associate Professor Pipsa Saharinen works on the molecular and cellular mechanisms that regulate blood vessel functions during inflammation and in cancer (www.helsinki.fi/saharinenlab). A special focus is on the dynamic regulation of vascular permeability by angiopoietin growth factor, cytokine and integrin adhesion receptor signalling. The group is funded by the European Research Council (ERC) and belongs to the Academy of Finland Centre of Excellence in Translational Cancer Biology. 

The Saharinen group is currently seeking for a

POSTDOCTORAL RESEARCHER  

for a fixed-term starting as soon as possible, upon mutual agreement.

Highly motivated individuals with a commitment to excellence and with the capability to work independently and as a part of a dynamic and collaborative research group are encouraged to apply. A PhD degree in Life or Biomedical sciences, or an MD PhD degree, as well as excellent communication skills in spoken and written English, are required. Strong background in vascular/cancer biology, imaging, mouse genetics, or cell/molecular biology is an advantage.

We offer an international, inspiring and supportive research environment, excellent research facilities with access to state-of-the art technologies and a competitive salary, which is comprised of two separate parts; the job requirement component (here, level 5) and the personal performance component based on previous qualifications, experience and personal work performance, as per defined in the General Collective Agreement for Finnish Universities. A six-month trial period will be applied.

The application should include the following documents as a single pdf-file: a cover letter describing previous achievements and motivation for the position (1 page), CV, track record of peer-reviewed publications, and names and contact details of two to three referees. To apply, please, go to

https://www.helsinki.fi/en/open-positions/postdoctoral-researcher-position

Apply by 15.4.2019. The position will be filled once a suitable candidate has been identified. Further information is available from Pipsa.Saharinen(a)Helsinki.fi, tel. +358-50-4486361.

Recent publications:

Hakanpaa et al., Targeting beta1-integrin inhibits vascular leakage in endotoxemia. Proc Natl Acad Sci USA. 115:E6467-E6476, 2018. 

Korhonen E, Lampinen A et al. Tie1 controls angiopoietin function in vascular remodeling and inflammation. J Clin Invest. 126: 3495-3510, 2016.

Hakanpaa et al. Endothelial destabilization by angiopoietin-2 via integrin β1 activation. Nature Commun 6: 5962, 2015.

Saharinen et al., Therapeutic targeting of the angiopoietin–TIE pathway. Nat. Rev. Drug. Disc. 16:635-661, 2017.

Eklund L, Kangas J, Saharinen P. Angiopoietin-Tie signaling in the cardiovascular and lymphatic systems. Clin. Science. 1:87-103, 2017. 

Suomen Solubiologit ry:n vuosikokous Jyväskylän yliopistolla, Bio- ja ympäristötieteiden laitoksella 15.3.2019

30.3.2019 | Ajankohtaista

Suomen Solubiologit ry sai vuosikokouksessaan uuden hallituksen vuodelle 2019:

Elina Siljamäki (Puheenjohtaja)
Jan Koski (Varapuheenjohtaja)
Anne-Mari Koivisto (Sihteeri)
Johanna Matilainen (Tiedotussihteeri)
Linda Kauppinen (Rahastonhoitaja)
Eveliina Korhonen (Hallituksen jäsen)
Jenni Tuominen (Hallituksen jäsen)
Emilia Kettunen (Hallituksen jäsen)
Niko Kangasniemi (Hallituksen jäsen)


Haluamme vielä kerran kiittää Kari Salokasta kuluneista hallitusvuosista sekä toivottaa tervetulleeksi uuden hallituksemme jäsenen, Niko Kangasniemen!



”Hei vaan hei! Olen juuri valmistumaisillani filosofian maisteriksi solu- ja molekyylibiologian opintosuunnasta Jyväskylän yliopistosta. Erityisiin mielenkiinnon kohteisiini biologian alalla kuuluvat mikroskopia ja neurotieteen sovellukset! Toivonkin valmistumisen jälkeen voivani siirtyä väitöskirjahommiin näiden aiheiden parissa.” – Niko Kangasniemi, Suomen Solubiologit ry:n hallituksen uusi jäsen


Kokouksessa suunniteltiin muun muassa syksyllä järjestettävää työelämäseminaaria. Luvassa on myös jotain täysin uutta niin Solubiologi-lehden kuin tapahtumienkin osalta, joten pysykäähän kuulolla!

PhD Position (drug disposition and kinetics, NanoSIMS imaging) – AstraZeneca, Gothenburg, Västra Götaland County, Sweden

30.3.2019 | Avoimet työpaikat

https://job-search.astrazeneca.com/job/gothenburg/phd-position-drug-disposition-and-kinetics-nanosims-imaging/7684/11340707

Location: Gothenburg, Västra Götaland County, Sweden Job reference: R-047805
Posted date: Mar. 27, 201

Are you interested in imaging the inner structure of single cells to understand how drug molecules reach their subcellular targets? Would you like to contribute to the establishment of new technologies to study drug disposition/kinetics in cells and tissues by doing your PhD at AstraZeneca, a company that is following the science and turning ideas into life changing medicines? Then you might be the one we are looking for!

AstraZeneca is now recruiting an Industrial PhD student to join theDrug Metabolism Pharmacokinetics (DMPK) New Modalities function within the Cardiovascular, Renal and Metabolism (CVRM) therapy area. CVRM is intensely pursing new drug modalities (e.g peptides, proteolysis targeting chimera “PROTACs”, RNA based therapeutics). Building an understanding about subcellular trafficking presents a real opportunity for the development of biopharmaceuticals where we will design molecules that effectively navigate these pathways to reach their targets.  This PhD project will be done as part of the University of Gothenburg Chemical Imaging Infrastructure (CII)under the direction of Andrew G. Ewing. The successful candidate will be employed by AstraZeneca, and work collaboratively within the CII located at the AZ BioVentureHub, Gothenburg, Sweden.

The PhD project

In the pursuit of applying new drug modalities we are finding that intracellular target engagement is of critical importance. Thus, information concerning intracellular drug concentrations is greatly needed. However, this information is difficult to obtain, and it has been suggested that this space is one of the most neglected areas of drug discovery. AstraZeneca, in association with the CII, has now begun to integrate Nanoscale secondary ion mass spectrometry (NanoSIMS) imaging into the suite of technologies to study drug disposition/kinetics in cells and tissues.

This project is a Stiftelsen för Strategisk Forskning (SSF) funded industrial PhD position with the aim of developing a single cell analytical nano-imaging technique to provide subcellular drug distribution imaging with high sensitivity. It aims to combine advanced analytical technologies to solve fundamental biological questions of intracellular drug trafficking, to study and quantify endosomal escape and concentration of drug at disease targets inside the cell. You will develop the ability to bridge the physical aspects of ion/matter interactions and the biological process under investigation. In addition to course work and basic training for the PhD, you will develop scientific concepts and communicate the results of your research verbally and in writing. The position includes teaching (laboratory or tutorial) at the undergraduate level or performing other duties corresponding up to 20 per cent of working hours. Your major responsibilities will be to pursue your own doctoral studies.

About the CII

The Chemical Imaging Infrastructure (CII) is a world-unique research infrastructure with a primary focus on high lateral resolution imaging mass spectrometry. Internationally CII has a world leading equipment base backed up by internationally recognized experts in the development and application of SIMS. CII is hosted by the Department of Chemistry and Chemical Engineering at Chalmers and by the Department of Chemistry and Molecular Biology at the University of Gothenburg.

Requirements

  • To qualify as a PhD student, you must hold a Master’s level degree in BioScience, Biochemical Engineering, Biotechnology, Biochemistry, Chemistry or a similar area.
  • A strong interest in biology is required and experience with cell culture an advantage. Experience with mass spectrometry and image analysis is preferred but not required.
  • Excellent English in writing and speaking and strong communication skills are required.
  • Due to the multi-disciplinary nature of this PhD project, you should preferably be curious, goal oriented, cooperation minded, and keen on transferring theoretic and applied academic work into practice.

If you are interested, apply now!

For more information please contact recruiting manager Michael Kurczy michael.kurczy@astrazeneca.com or academic supervisor Andrew Ewing andrew.ewing@gu.se

Welcome with your application no later than April 21, 2019.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.