12.11.2018 | Avoimet työpaikat
https://www.exosome-rna.com/post-doc-position-available-medicine/?utm_campaign=shareaholic&utm_medium=twitter&utm_source=socialnetwork
Environment and Background
The Lawrence J. Ellison Institute for Transformative Medicine of USC is a multidisciplinary research institute developing innovative approaches in the prevention and treatment of cancer in order to significantly impact patients’ health and quality of life. We focus on understanding complex tumor-microenvironmental interactions and discovering optimal approaches for personalizing patient care. Our vision is to use a patient’s own metrics (genetic information, molecular tumor markers, dynamic tumor cell behaviors and drug responses across diverse microenvironments) to determine the most effective treatment. We are currently investigating a broad range of biological systems, including cell culture, mouse models, and patient-derived tissues.
Position Responsibilities
We are seeking a talented and passionate postdoc who has a strong interest in cancer biology. The qualified candidate will study the impact that exosomes derived from the tumor microenvironment have on pancreatic cancer initiation, progression, and therapeutic resistance using 2D and 3D cell cultures and mouse models. The projects will involve isolating extracellular vesicles produced by cancer associated fibroblasts, and pancreatic cancer cells; characterizing the cargo of the isolated microvesicles; and examining if the isolated microvesicles are able to induce phenotypic and genotypic changes on neighboring healthy and diseased cells. The candidate will work in close collaboration with a diverse team consisting of cancer researchers, computational scientists and clinicians. Key technical skills include mammalian tissue culture (2D and 3D), qRT-PCR, Western blot, immunofluorescence, and various cell proliferation and cell survival assays.
Requirements
Candidates should have a Ph.D. degree in molecular/cellular biology, biochemistry, or other relevant discipline. Candidates should have productivity as demonstrated by publication record. Applicants must have training in mammalian tissue culture (2D and 3D), experience with in vivo animal models, and familiarity with immunohistochemistry. Excellent verbal and communication skills, and the ability to work in a team environment are required. Key success factors in the performance of this position include being organized with the ability to maintain records accurately, the ability to collaborate across disciplines, and curiosity.
Interested individuals should provide their CV and a 1-2 page cover letter describing their professional goals and how their research experience can advance these research goals.
Other:
Preferred Education: Ph.D. degree in molecular/cellular biology, biochemistry, or other relevant discipline
Preferred Experience: 1 year
Preferred Field of Expertise: Training in mammalian tissue culture (2D and 3D) and familiarity with exosomes, in vivo animal models, qRT-PCR, and immunohistochemistry.
Posting Salary Range:
Percentage of Time: 100%
Fixed Term: Yes
Fixed Term: 1-year fixed term
Minimum Education: Ph.D or equivalent doctorate within previous five years
Minimum Experience: 0-1 year
Minimum field of Expertise: Directly related education in research specialization with advanced knowledge of equipment, procedures and analysis methods.
12.11.2018 | Tapahtumat
https://helsinginyliopisto.etapahtuma.fi/en-us/Kalenteri/English?id=54100
Eric Lander, President and Founding Director of the Broad Institute of MIT and Harvard, USA:
”Using the Periodic Tables of Life: Unraveling the Genetics of Common Disease and the Trajectories of Cellular Development”
Host: Mark Daly, FIMM-HiLIFE
Coffee served after the lecture in B lobby.
Registration by Tuesday 13 November
Contact: Susanna Rosas, FIMM
12.11.2018 | Avoimet työpaikat
Postdoctoral Fellow Positions in Epigenetics, human iPS cells, 3D Bioprinting, Cellular Therapies, Hematopoietic Stem Cell Biology, Bioengineering, and Blood Cancers: Columbus, OH, United States.
Multiple postdoctoral fellow positions are available in the Dhvanit Shah Laboratory (www.shahlaboratory.org) at the Center for Childhood Cancers and Blood Diseases, Nationwide Children’s Hospital & Ohio State University, Columbus OH, United States.
The Shah laboratory provides a dynamic microenvironment that offers excellent opportunities for intellectual exchange and collaborations among investigators from diverse fields. We investigate the origin, development, and differentiation of hematopoietic stem cells (HSCs), and their utility in treating patients with blood and bone marrow diseases. We have expertise in utilizing zebrafish, mice, and human induced pluripotent stem (iPS) cells to analyze novel genes and mechanisms important for blood formation. Our goals are to utilize our knowledge in developing cellular- and mechanism-based therapies as well as generating functional HSCs for the treatment of hematological diseases.
Position # 1: Epigenetics of Hematopoietic Stem Cell Development and Disorders.
The ideal candidate will have Ph.D., M.D., or M.D./Ph.D. in Regenerative Medicine, Stem Cells, Immunotherapy, Hematology, Oncology, and/or Biology. This position offers an excellent opportunity to learn and apply skills in epigenetics, directed differentiation of human induced pluripotent stem cells (iPSCs), HSC transplant, xenograft, computational biology, high-throughput screening, gene-editing, and/or molecular and cellular biology techniques.
Position # 2: Bioengineering of 4D or 3D Tissue Scaffold Development.
The ideal candidate will have Ph.D., M.D., or M.D./Ph.D. in Tissue Engineering, Biomaterials, Biophysics, Machine Learning, Systems Biology, Chemical Engineering, and/or Drug Development. This position offers an excellent opportunity to learn and apply skills in organoid development, 3D bio-printing, Bio-MEMS, artificial intelligence, microfluidics, proteomics, and/or medicinal chemistry.
Strong background in one or more of these areas is preferred but not required. Qualified candidate should be able to work independently as well as in a group environment. Positions are reviewed on a rolling basis and open until March 31, 2019.
Interested candidates should send their cover letter, CV, and contact details of three references to:
Dr. Dhvanit I. Shah
Center for Childhood Cancer & Blood Diseases,
Nationwide Children’s Hospital &
Ohio State University College of Medicine
700 Children’s Drive, WA 5015
Columbus, OH 43205
dshahlab@gmail.com
11.11.2018 | Uutiset
Itä-Suomen yliopistossa työskentelee useita tutkijoita, joiden mielenkiinnon kohteena ovat solunulkoiset vesikkelit. Nykyään ymmärretään, että nämä pienet kalvorakkulat ovat tärkeitä solujen ja elinten välisessä viestinnäsä, mutta niiden merkittävä rooli erilaisissa sairauksissa on vasta avautumassa tutkijoille. Vesikkelitutkimuksen potentiaali on hyvin suuri, koska se voi mahdollistaa tulevaisuudessa vesikkeleiden käytön niin ei-invasiivisessa diagnostiikassa, hoidossa kuin lääkeainekuljettiminakin. Katso tutkijoiden haastattelu Itä-Suomen yliopiston Saima-lehdestä!
http://www.uef.fi/fi/web/saima/solujen-viestintavalineet-uuteen-kayttoon
Kuva: Kirsi Rilla
11.11.2018 | Uutiset
https://www.hs.fi/sunnuntai/art-2000005893935.html
Tämän päivän Helsingin Sanomissa Katri Kallionpään tarina nielusyöpään sairastumisesta. Terveyden ja hyvinvoinnin laitoksen työryhmä tulee antamaan tammikuussa arvionsa siitä, että tulisiko myös pojat rokottaa hpv-virusta vastaan, niinkuin on tehty 11-12-vuotiaille tytöille vuodesta 2013 alkaen. Tutkijat ovat tuottanet uutta tietoa runsaasti 17 vuoden aikana ja eloonjäämisennusteet ovat parantuneet huimasti, vaikka nielusyöpä yleistyy edelleen. Rokottaminen on ehdottoman tärkeää myös hpv-viruksen aiheuttamien nielusyöpien leviämisen estämisessä. #syöpä #syöpätutkimus #rokotukset
8.11.2018 | Koulutukset / seminaarit
Suomen Solubiologit ry:n hallitus haluaa kiittää kaikkia Rohkeat Biologit -seminaariin osallistuneita sekä myös mahtavia puhujiamme, Virpi Muhosta, Leena Valmua, Matti Jalasvuorea sekä Leona Gilbertiä! Millään emme olisi halunneet päättää mahtavia keskusteluita puheiden jälkeen 🙂 Mikäli olit paikalla seminaarissa, arvostaisimme kovasti palautettasi! Mitä pidit puheista, oliko teema mielenkiintoinen? Tavoittiko tapahtuman mainontamme tarpeeksi monen, voisimmeko tehdä mielestäsi jotain vielä paremmin? Etkö päässyt paikalle kurssien päällekkäisyyksien takia? Otamme myös vastaan ideoita tapahtumista, joita haluaisit meidän järjestävän, millaiseen seminaariin/tapahtumaan juuri sinä haluaisit tulla? Kommentoi/laita yksityisviestiä Instagramissa, Facebookissa tai sähköpostin muodossa osoitteeseen suomensolubiologit@gmail.com!
8.11.2018 | Avoimet työpaikat
Ph.D. student – VTT, Vuorimiehentie 3, Espoo, 1 FI-02044, FI
Ph.D. student, fungal molecular biology
Form of employment: Full time, Fixed term
Locations: Espoo, Finland
Job area: Research and Development
Application period: Monday, October 29, 2018 – Sunday, November 25, 2018
With us you will be responsible for
completing your Ph.D. thesis on the study of cellular metabolism and production of extracellular proteins. You will be working as a part of an Academy of Finland funded research project “Interplay between metabolism and protein secretion in saprotrophic fungi”. The main emphasis of your work will be identifying important regulatory connections between cellular metabolism, secretory pathway and production of extracellular enzymes in the saprotrophic model organism Trichoderma reesei. As a member of the Protein Production Team, you will be part of wider efforts to better understand and develop fungal protein production hosts, such as Trichoderma reesei.
We expect you to have
completed your master’s degree so that you can start your Ph.D. thesis work in January 2019. You should have good laboratory skills and experience in molecular biology techniques and bioinformatics. Experience working with yeast or filamentous fungi would be beneficial, but not mandatory. Strong spoken and written English skills are required.
As a person you are
motivated to complete a Ph.D. thesis and willing to take initiative in getting the project accomplished. You should have strong communication skills as well as be able to work both independently and as a member of a team. You should have curiosity towards various scientific and technological challenges. You should be willing to travel and work abroad as part of short collaboration projects.
We offer
an opportunity to complete a Ph.D. thesis working on an interesting and cutting edge research project, expert guidance, and an opportunity to work with an experienced research team to better understand fungal protein production hosts used for production of industrial enzymes.
For further information
Chris Landowski
Research Team Leader
christopher.landowski@vtt.fi
8.11.2018 | Avoimet työpaikat
R&D Scientist – PerkinElmer Inc., Turku, VARS
PerkinElmer is currently looking for
R&D Scientist with Bioaffinity Assay expertise
Turku, Finland
The Turku Site, with 550 employees, represents one of PerkinElmer’s major manufacturing and product development sites for newborn- and maternal fetal health screening. As the global market leader in newborn screening, our solutions have tested over 560 million babies worldwide for life-threatening diseases.
Role description:
- You will be a key member and expert of technologies related to bioaffinity assays in product development teams
- You will apply the scientific method to solve problems and to design new products that are safe and effective in their intended uses
- You will have an essential role in planning and reporting of feasibility, stability and verification studies, and process characterization and validation studies
- You will work in the lab yourself as well as direct the work of lab technicians
- You will be interacting a lot within your team and with other teams from various functions present at Turku site and other PerkinElmer sites
Role requirements:
- Degree (MSc or PhD) in Chemistry/Biology/Biochemistry or equivalent education
- Proven expertise on bioaffinity assays (immunoassays, ligand binding assays) and especially: DELFIA, ELISA, CLIA, Upconverting label technologies
- Fluent reporting and communication skills in English and Finnish
- Proactive, resourceful, independent and a good team player in the cross-functional and international development team
- Strong background and practical working knowledge from GLP/GMP level Pharma, Biotech or Life Science industry
What we offer:
- Inspiring leadership and exceptional employees
- Dynamic and innovative culture
- Focus on career development
- Collaborative and diverse environment
This position is permanent. Please apply by November 18th, 2018.
PerkinElmer Turku Site is a drug free site and a medical examination for new employees includes a drug test.
7.11.2018 | Avoimet työpaikat
NIH-funded Postdoctoral Fellowship Position, to begin as early as June 2019
(duration: 2-5 yrs).
RNA Metabolism in Innate Immunity
National Institutes of Health (NIH), Bethesda, Maryland
The Fellow will investigate molecular mechanisms involved in RNA metabolism relevant to cytoplasmic RNA polymerase III (cyto-Pol III)-mediated innate immune mRNA induction and metabolism. Candidates must hold a Ph.D. or M.D. and have less than 5 years postdoctoral experience. Expertise in molecular biology, genetics and/or biochemistry is required, as are strong letters of recommendation. The successful candidate will confer regularly with the principal investigator but must develop self-directed research and have good technical, presentation, and communication skills as essential parts of the training experience.
Interested candidates should email a cover letter that details their specific interests in the research interests of the Maraia lab.
Interested candidates should send a cover letter that details their specific interests in the research areas of the Maraia lab, C.V. and a list of three references with their e-mail addresses and telephone numbers via e-mail to:
Richard J. Maraia, M.D.
Maraia lab interests:
•cytoplasmic RNA polymerse III (cyto-Pol III)-mediate innate immune response
•mRNA biased codon use and effects of variable tRNA gene complement.
•Anticodon modification by tRNA isopentenylytransferase and its role in translation.
•Molecular mechanisms of La-related protein -4 (LARP4) function in translation.
•Role of the La protein in tRNA production.
•Molecular mechanisms of transcription termination by RNA polymerase III.
6.11.2018 | Ajankohtaista
Järjestimme seminaarin teemalla Rohkeat biologit – Intohimo ja innovatiivisuus suunnannäyttäjinä. Puhujina seminaarissa olivat Virpi Muhonen (Askel Healthcare Oy), Leona Gilbert (Te?ted Oy), Leena Valmu (dosentti, lasten- ja nuortenkirjailija) ja Matti Jalasvuori (akatemiatutkija). Mika Nurmikolu Evogenom Oy:sta joutui perumaan osallistumisensa, mutta saimme kuitenkin Suomen Akatemian akatemiapalkinnon saaneen Matin mukaan seminaariimme! Puheet olivat äärimmäisen inspiroivia ja opiskelijat olivat selvästi kiinnostuneita erilaisista uratarinoista. Keskustelu jatkui rennosti viinin ja snacksien merkeissä 😊
