Orion’s Immuno-Oncology (IO) research team is looking to recruit an enthusiastic and motivated in-vivo Research Scientist/Senior Scientist to join the IO team on permanent basis in Turku, Finland.
Description of position
In this role you will contribute to the in-vivo studies and unit’s technical excellence. You will be responsible for supporting IO drug discovery projects and ensuring the highest standard of testing environment. In this role you will have an unique opportunity to work with a range of treatment modalities ranging from small molecules to biologics such as bispecific antibodies and CAR-T cells. In addition, you will also participate in supporting other in-vivo studies performed within the Oncology Research department.
Main responsibilities;
Complying with the local Animals (Scientific Procedures) Act and the associated Codes of Practice for the Housing and Care of the Animals used in Scientific Procedures.
Design, setup and implement IO tumor models in conjunction with internal project teams and in line with the regulations.
Establish and run in-vivo efficacy, PK/PD and mechanism of action studies to test novel IO and other oncology drugs in tumor and non-tumor bearing rodents.
Establish and validate human and mouse ex vivo primary immune cells assays to study the mechanism of action of IO drugs.
Provide immunology expertise for the project teams and act as an in-vivo project lead within the IO team.
Co-ordinate with the line-manager and project team to ensure timely delivery of data and provide reports and presentations as required.
Provide expert knowledge of tumor immunology, cancer Immunotherapy and tumor biology to the project team.
Maintaining high quality and accurate records in accordance with the appropriate regulatory standards.
Working in close collaboration with in-vitro scientists, in-vivo technicians and animal welfare unit.
Supporting in-vivo needs across the Oncology research organization where necessary
Description of Unit
Immuno-Oncology (IO) is one of four Research teams in Orion’s Oncology R&D. IO team is accountable for novel drug discovery projects, identification and validation of potential IO drug targets within state-of-the-art laboratories and technologies.
We Offer
We offer you the opportunity to show your talent in one of the most innovative companies in Finland. You get a chance to work in a challenging field of work with excellent colleagues. You will also have the chance to do meaningful work and build the future of Orion. We are striving for excellence in everything we do. We succeed, learn together and appreciate each other. You’ll be empowered to deliver value. Read more about our values!
Requirements
To be a successful in-vivo Research Scientist/Senior Scientist ideally you should have the following educational and professional work experiences:
PhD degree in Immunology, cancer biology or Immuno-Oncology with 3+ years of Industry or academic experience.
Strong understanding of Immuno-Oncology, cancer immunotherapy, immune cell signalling as evidenced by high impact journal publications or poster presentation at IO conferences.
Previous experience with bispecific antibodies and CAR-T cells is a plus.
Strong in-vivo research experience especially using mouse syngeneic, humanised mouse tumor models and xenograft tumor models
Demonstrate ability to independently design, conduct and interpret the data from in-vivo mouse tumor studies.
Proven experience using standard immunology techniques to support in-vivo and ex-vivo analysis.
Demonstrate proficiency in performing tissues harvest and processing samples for multi-colour flow cytometry, multiplex ELISA, IHC, single cell RNA sequencing and gene expression analysis.
Sound technical competence that includes rodent handling, injections (IV, IP, SC, and PO), palpation, bleeding, and tissue harvest and ex-vivo analysis methods.
Competency in using GraphPad Prism, flowjo, nSolver software and other standard office software.
Excellent attention to details with strong communication skills.
Flexibility and willingness to learn new techniques and take additional responsibilities as a member of the research team.
Additional information
Please send your application with a latest CV, cover letter and salary request in English by 31st August 2022 at the latest. We may start interviewing candidates before application period closes.
For further information, please contact Dr Anil Thotakura, Head of Immuno-oncology, +358 50 966 7229, during the following times: July 29th from 3.00 to 5.00 pm, August 4th, 19th & 26th from 3.00 to 5.00 pm.
Nanoform is an innovative drug particle engineering and nanotechnology company listed on the Premier-segment of Nasdaq First North Growth Market in Helsinki and Stockholm. Nanoform works together with pharma and biotech partners globally to reduce attrition in clinical trials and enhance their molecules’ formulation performance through its nanoforming services. Leveraging our in-house developed AI engine Starmap® we can also predict which customer molecules show most promise for our technology. Nanoform’s capabilities include GMP manufacturing, and its services span the small to large molecule development space with a focus on solving key issues in drug solubility and bioavailability and on enabling novel drug delivery applications.
Title
As part of our company growth we are seeking a R&DProduction Technician to support the Bio-team. The Production Technician will report to the Bio-team leader. The location for the job is in our facilities in Helsinki, Finland.
Job Purpose
To produce nanoformed materials for customer and internal projects. The R&D Production Team in Nanoform will be working on a shift rotation.
Key Responsibilities:
· Run the production lines in a safe and effective manner following all applicable Standard Operating Procedure (SOPs)
· Sample raw materials and finished goods in accordance with SOPs.
· Produce shift reports and fill in tracking sheets as required.
· Assembly and cleaning of the R&D production line and associated equipment according to standards and SOPs as required and record in log-books.
· Adhere to health, safety and environment rules at all times.
· Assist in the production and review of SOPs
· Work with the QC, Pharmaceutical Development, and Engineering teams as required.
Required Education and Experience
· Ideally a minimum of 5 years of relevant manufacturing experience in Pharmaceutical or Process industry.
· Good technical knowledge and understanding of laboratory procedures, methodology and standards.
· Proven track record in product manufacture to high standards of safety and quality.
· Capacity to produce clear records and data reports.
Personal qualities we are looking for
· You are a doer and have an accurate working style
· You are flexible in working in a team as well as independently
· You have an ability to work in a high-performance environment
· Fluent English, both written and spoken
What we offer to you
· A great team to join with highly skilled and motivated colleagues.
· Encouraging and forward-looking team spirit.
· You will be part of a team that invents world-class solutions for the pharma industry.
· We provide extensive learning opportunities. You are able to utilize your skills and competencies widely as we continuously create something new.
· Competitive compensation package with broad employee benefits selection.
· Possibility to be part of a unique growth company in the pharma industry. We like challenges and want everyone to enjoy solving them together.
If you have any questions, please contact the Bio-team leader Maria Lume (maria.lume@nanoform.com)
Please apply by submitting your application letter and CV to us latest by 4. September 2022.
We will process the applications as they come and fill the position as soon as we find the right candidate.
Nanoform is an innovative drug particle engineering and nanotechnology company listed on the Premier-segment of Nasdaq First North Growth Market in Helsinki and Stockholm. Nanoform works together with pharma and biotech partners globally to reduce attrition in clinical trials and enhance their molecules’ formulation performance through its nanoforming services. Leveraging our in-house developed AI engine Starmap® we can also predict which customer molecules show most promise for our technology. Nanoform’s capabilities include GMP manufacturing, and its services span the small to large molecule development space with a focus on solving key issues in drug solubility and bioavailability and on enabling novel drug delivery applications.
R&D Scientist or R&D Senior Scientist – Biopharmaceuticals
With a view of developing our organization further, we are now seeking an experienced R&D Scientist or R&D Senior Scientist who shares our ambition to develop break-through products for nanoparticles, to join our Bio-team in the R&D unit. The position is fulltime, and it is focused on the characterization and development of biological nanoparticles. The position includes laboratory work. The scientist reports to the Bio-team leader. The location for the job is in our facilities in Helsinki, Finland. The seniority of the applicant will be reviewed during the recruitment process.
You will be responsible for
Designing and developing biopharmaceuticals and processes for drug products for R&D purposes
Planning, coordinating and ensuring timely execution of realistic protocols and reports for feasibility work following current Good Manufacturing Practices and company standards
Evaluating product testing results and provide next steps for continued development
Preparation and delivery of reports, SOPs, and technical presentations for both internal and external parties
Participating in relevant meetings/teleconferences with clients
Collaborating within cross-functional teams to ensure products are developed to targeted consumer preferences on time and agreed-upon cost targets
Managing multiple development projects in a timely manner
Staying current with recent advances and trends in the drug delivery technology and regulatory policies
Providing support to the Pharmaceutical Development unit and QC
Other duties as assigned
Ideal experience
Proficiency in English, both written and spoken, is a prerequisite
Demonstrated skill in developing biopharmaceuticals
Experience of Good Laboratory Practices
Experience with nanoparticles
Experience with the analytical characterization of large molecule formulations
Knowledge of protein and nucleic acid chemistry, degradation pathways, and stabilization techniques
Knowledge of regulatory documentation, in particular ICH pharmaceutical guidelines
Experience with various delivery routes and manufacturing processes
A high degree of professionalism, ethics and integrity
Knowledge in the application of QbD concept in design, execution, and interpretation of product and process development experiments
Familiarity with Intellectual Property (IP)
Required Degree
R&D Scientist:
· Master’s degree in Biochemistry, Chemical Engineering, Bioengineering, Nanotechnology, Pharmaceutical Sciences or related field with at least three years of relevant industry experience
· Preferable: PhD degree in Biochemistry, Chemical Engineering, Bioengineering, Nanotechnology, Pharmaceutical Sciences or related field with relevant industry experience with at least three years of relevant industry experience
R&D Senior scientist:
· PhD degree in Biochemistry, Chemical Engineering, Nanotechnology, Pharmaceutical Sciences or related field with at least five years of relevant industry experience
Personal qualities we are looking for
· Excellent laboratory skills and experience working with biological compounds
· Strong organizational skills, skillful experiment planning and attention to detail
· Safe and productive work mindset
· Excellent problem-solving skills
· You can work in a high-pressure environment
Strong ability to prioritize, multi-task, and work in an interdisciplinary and evolving environment
Good presentation and written/verbal communication skills
Handling multiple projects and priorities at the same time in a timely manner
Good teamwork skills, contributing to a good working environment
What we offer to you
· A great team to join with skilled and highly motivated colleagues
· Encouraging and forward-looking team spirit
· Possibility to take responsibility and grow your competencies
· Chance to be a part of a team that invents world-class solutions for the medical/healthcare industry
· Opportunity to utilize your skills and competencies widely as we continuously create something new
· Competitive compensation package with broad employee benefits selection
· Possibility to be part of a unique fast-growing company in pharma industry
We like challenges and want everyone to enjoy solving them together!
If you have any questions, please contact the Bio-team leader Maria Lume (maria.lume@nanoform.com)
Please send your CV and application letter to us latest by 4. September 2022.
We will process the applications as they come and fill the position as soon as we find the right candidate.
a doctoral researcher (PhD / postgraduate student) with life science background
a postdoc with metabolomics expertise
to join our Academy of Finland research project studying the impacts of maternal microbial metabolites and extracellular vesicles on the fetal immune system development, in humans and other mammals.
Väitöskirjatutkijan ja postdocin pestit: emän/äidin mikrobiston metaboliitit ja solunulkoiset vesikkelit sikiönkehityksessä
Etsimme Akatemia-hankkeeseemme
väitöskirjatutkijaa, jolla on biotieteellinen koulutus
metabolomiikka-alan postdoc-tutkijaa
tutkimaan kanssamme emän/äidin mikrobiston metaboliittien ja solunulkoisten vesikkelien vaikutuksia immuunijärjestelmän kehitykseen sikiöaikana, ihmisillä ja muilla nisäkkäillä.
Orion’s Immuno-Oncology (IO) research team is looking to recruit an enthusiastic and motivated in-vivo Research Scientist/Senior Scientist to join the IO team on permanent basis in Turku, Finland.
Description of position
In this role you will contribute to the in-vivo studies and unit’s technical excellence. You will be responsible for supporting IO drug discovery projects and ensuring the highest standard of testing environment. In this role you will have an unique opportunity to work with a range of treatment modalities ranging from small molecules to biologics such as bispecific antibodies and CAR-T cells. In addition, you will also participate in supporting other in-vivo studies performed within the Oncology Research department.
Main responsibilities;
Complying with the local Animals (Scientific Procedures) Act and the associated Codes of Practice for the Housing and Care of the Animals used in Scientific Procedures.
Design, setup and implement IO tumor models in conjunction with internal project teams and in line with the regulations.
Establish and run in-vivo efficacy, PK/PD and mechanism of action studies to test novel IO and other oncology drugs in tumor and non-tumor bearing rodents.
Establish and validate human and mouse ex vivo primary immune cells assays to study the mechanism of action of IO drugs.
Provide immunology expertise for the project teams and act as an in-vivo project lead within the IO team.
Co-ordinate with the line-manager and project team to ensure timely delivery of data and provide reports and presentations as required.
Provide expert knowledge of tumor immunology, cancer Immunotherapy and tumor biology to the project team.
Maintaining high quality and accurate records in accordance with the appropriate regulatory standards.
Working in close collaboration with in-vitro scientists, in-vivo technicians and animal welfare unit.
Supporting in-vivo needs across the Oncology research organization where necessary
Description of Unit
Immuno-Oncology (IO) is one of four Research teams in Orion’s Oncology R&D. IO team is accountable for novel drug discovery projects, identification and validation of potential IO drug targets within state-of-the-art laboratories and technologies.
We Offer
We offer you the opportunity to show your talent in one of the most innovative companies in Finland. You get a chance to work in a challenging field of work with excellent colleagues. You will also have the chance to do meaningful work and build the future of Orion. We are striving for excellence in everything we do. We succeed, learn together and appreciate each other. You’ll be empowered to deliver value. Read more about our values!
Requirements
To be a successful in-vivo Research Scientist/Senior Scientist ideally you should have the following educational and professional work experiences:
PhD degree in Immunology, cancer biology or Immuno-Oncology with 3+ years of Industry or academic experience.
Strong understanding of Immuno-Oncology, cancer immunotherapy, immune cell signalling as evidenced by high impact journal publications or poster presentation at IO conferences.
Previous experience with bispecific antibodies and CAR-T cells is a plus.
Strong in-vivo research experience especially using mouse syngeneic, humanised mouse tumor models and xenograft tumor models
Demonstrate ability to independently design, conduct and interpret the data from in-vivo mouse tumor studies.
Proven experience using standard immunology techniques to support in-vivo and ex-vivo analysis.
Demonstrate proficiency in performing tissues harvest and processing samples for multi-colour flow cytometry, multiplex ELISA, IHC, single cell RNA sequencing and gene expression analysis.
Sound technical competence that includes rodent handling, injections (IV, IP, SC, and PO), palpation, bleeding, and tissue harvest and ex-vivo analysis methods.
Competency in using GraphPad Prism, flowjo, nSolver software and other standard office software.
Excellent attention to details with strong communication skills.
Flexibility and willingness to learn new techniques and take additional responsibilities as a member of the research team.
Additional information
Please send your application with a latest CV, cover letter and salary request in English by 31st August 2022 at the latest. We may start interviewing candidates before application period closes.
For further information, please contact Dr Anil Thotakura, Head of Immuno-oncology, +358 50 966 7229, during the following times: July 29th from 3.00 to 5.00 pm, August 4th, 19th & 26th from 3.00 to 5.00 pm.
#LI-Orion
Approved medical examination which also includes drug testing is required prior to the employment. We will also carry out a security clearance prior to the employment for the selected person.
Orion Corporation operates in more than 30 countries, where we Orionees, 3300 in total, work in all kinds of positions. Among us there are Research Scientists, Laboratory Technicians, Engineers and IT Specialists as well as people working in Production, just to mention some examples. We offer diverse and responsible jobs to our personnel in a truly multi-disciplinary work environment. We encourage people to develop their competences and offer opportunities to affect the job description and creating their own career path at Orion. We are searching for top talents who are ready to share our passion for the work that we do.
Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue of approximately $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, increasing productivity in their laboratories, improving patient health through diagnostics or the development and manufacture of life-changing therapies, we are here to support them. Our global team of more than 100,000 colleagues delivers an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, Patheon and PPD. For more information, please visit www.thermofisher.com.
About Finland
Our Finland locations include Vantaa and Joensuu, employing over 1,000 professionals supporting functions such as production, instrument and reagent manufacturing, R&D, marketing, sales, quality, administrative support and supply chain. We hire experts in different fields including engineering, chemistry, microbiology and bioinformatics. Our Vantaa site develops pipettes and microplate instruments as well as clinical chemistry and industrial chemistry analyzers, laboratory automation solutions and food safety kits. It is conveniently located close to the Vantaankoski railway station. Please read more about Finnish sites, innovative work and collaborative colleagues at https://jobs.thermofisher.com/global/en/finland.
Take a look how our software professionals in Finland are enjoying our innovative work atmosphere and the role they are playing in helping humankind: https://youtu.be/wDm4NLxq3nI
How will you make an impact?
We are looking for a proactive and self-driven Laboratory Technician for a fixed term position for the period 15.8.2022-31.12.2023 with potential to a permanent position in Production after 1.1.2024. You enjoy working with high technology products and driving multiple initiatives at the same time. You want to develop yourself and the way of working. We offer motivating tasks in an innovative and international working environment.
What will you do?
You will be part of the Molecular Food Protection team, with up to 35 other members, responsible for designing and developing new molecular diagnostic products to complement the current microbiology product range, and production and support of these products.
Your work will include manufacturing and quality control of Food Protection molecular products (reagents related to DNA extraction and qPCR) and conducting molecular experiment work on the enhancement of Molecular Food Protection manufacturing processes. You will conduct molecular and microbial methods such as sample preparation, real-time PCR experiments, analyze results and maintain instruments and laboratory. You are expected to contribute by thinking through issues related to laboratory work. You are well-organized and able to maintain formal laboratory and manufacturing records. You enjoy working with high technology products and want to develop yourself and the way of working.
How will you get here?
>1 years relevant experience of working in laboratory and/or production environment
Solid knowledge of real-time PCR and molecular methods
Knowledge of basic microbiological techniques and methods
Good computer skills and experience in MS Office package
Good written and spoken Finnish, and preferably English
Strong teamwork capabilities
Good communication and interpersonal skills
Experience of lyophilization and enzyme technology is preferred
Please send in your application, including a cover letter, CV and salary request in English. Please apply via http://jobs.thermofisher.com/ by 22nd of July 2022. Reference: 210717BR. Please apply as soon as possible, the position will be filled as soon as suitable candidate is found.
If you have questions about the position and/or Thermo Fisher Scientific – please contact Pauliina Heikkinen, Manufacturing Science Supervisor, +358503581432 (on Monday 18.7. at 13:00-14:00 or Tuesday 19.7. at 10:30-11:30).
About us:
Each one of our 100,000 extraordinary minds has a unique story to tell. It’s not just a career, it’s a chance to realise your best – professionally and personally.
Join us and contribute to our mission—enabling our customers to make the world healthier, cleaner and safer: http://jobs.thermofisher.com
Are you an expert in human genetics and inherited diseases? Do you have the ambition to utilize your experience in genetic interpretation whilst being among the pioneers of the molecular era of medicine? Are you passionate about helping patients? If you answered “yes,” you might be the person we are looking for!
Blueprint Genetics is on a mission to bring world-class genetic knowledge to mainstream healthcare. We are a team of experienced professionals with diverse backgrounds, who share a passion for helping patients and families affected by inherited disorders. We work with hundreds of clinics around the globe and the quality of our interpretation has been praised by many of the world’s best medical centers.
To support our rapid growth, we are looking for a Geneticist to join our Helsinki Clinical Interpretation Team.
Job description
In this Geneticist position, you will have the opportunity to work with an experienced and motivated geneticist team that places great value in high-class clinical interpretation. We have a diverse genetic testing portfolio, including over 220 panels across 14 medical specialties, whole exome sequencing, approximately 3,900 single genes, and targeted variant analysis
Your daily work will entail analyzing the genetic data with our in-house developed interpretation tool and writing the test results into high-quality written statements. Interpretation of the data requires the use of several databases, genetic tools, and understanding of how the clinical history of the patient matches with the findings. In more challenging cases, you are supported by a group of clinical consultants in various medical specialties.
What we expect from you
We are looking for a person with a patient-first mindset, who is truly motivated to find answers for individuals affected by inherited diseases. You are able to deliver high-quality results independently, and taking responsibility comes naturally to you. At the same time, you are a team player with an eagerness to work towards a common goal. You are enthusiastic about keeping up with the most recent scientific findings and developing your expertise. You work efficiently under pressure in a fast-paced production environment and you adjust effortlessly to evolving situations.
Our ideal candidate has:
PhD in Genetics or Molecular Medicine (or equivalent), or Clinical Laboratory Geneticist degree in Clinical Molecular Genetics / Laboratory Genetics and Genomics
Excellent understanding of human genetics, inheritance models and inherited human diseases, and the ability to understand medical terminology and learn clinical aspects of the diseases
Uncompromised attention to detail. In practice this means that an analytical, critical and systemic approach, as well as ability to follow rules, is needed to maintain coherent variant classifications throughout the team and the high quality of the reports.
Excellent verbal and written skills in English are a necessity
Additional valued assets:
Knowledge of current genomic information and variant databases, in addition to experience in NGS methods
Research or clinical experience in interpreting genetic test results utilizing NGS, Sanger sequencing and other methods
Experience in whole exome analysis
Verbal and written skills in Finnish
What we offer
At Blueprint Genetics, the work you do has a real impact on patients’ lives, and this commitment is something our team takes great pride in.
Our global and multidisciplinary team of geneticists is a unique group of more than 50 PhD level scientists and Clinical Laboratory Geneticists. Our team members have an average of more than 13 years of previous scientific experience, several years in clinical diagnostics (per person), and altogether approximately 500 peer-reviewed scientific articles published. Thus, you will be supported by a group with extensive experience in the field.
In this role, you get to utilize your skills and experience in an environment that is unlike anything you have experienced before. Our working culture is open, positive and low-hierarchy. We offer you a rapidly evolving working environment, where you can learn and grow together with great colleagues!
If you are up for the challenge, please submit your application and CV at the latest by August 14, 2022 with your salary request.
This position is preferably based out of our office in Espoo, but there is also a possibility to work remotely from other parts of Finland.
At the heart of QIAGEN’s business is a vision to make improvements in life possible.
We are on an exciting mission to make a real difference in science and healthcare. We are still the entrepreneurial company we started out as and have today achieved a size where we can bring our full power to many initiatives and to our presence across the globe. Our most valuable asset are our employees – more than 5000 in over 35 locations around the world. Our ambition is to ensure we have outstanding and passionate people working in the best teams and we are constantly looking for new talent to join us. There are few players who have shaped the world of modern science and healthcare as much as QIAGEN, and we have only just started. If you are looking to advance your career, are seeking new challenges and opportunities, enjoy working in dynamic and international, diverse teams and want to make a real impact on people’s lives, then QIAGEN is where you need to be.
Join us. At QIAGEN, you make a difference every day.
Your Tasks
In your role you are focused on field- and office-based, post-sale technical support to all QIAGEN customers and are responsible for on-site repairs, installations, customer training, education and/or troubleshooting on QIAGEN instrumentation, including consumables and applications in all markets as well as coordinating with other internal departments to optimize protocols or aid in experimental design.
You develop and maintain highest possible level of technical knowledge of automation / instrumentation as well as related applications and provide second-tier support for Sales and Technical Support by performing trainings such as train the trainer, seminars for internal and external customers
You actively promote QIAGEN products including Service and Support products and assist in exceeding revenue targets, support demonstrations and evaluations if needed and give active feedback to Sales, Marketing, Global Product Support, Global Training and Management
You utilize all available tools such as Service Reports, Spare Part & Service Manuals, ISI Notes, and the relevant databases to input information that will increase effectiveness
You will be required to work with hazardous substances such as acids and solvents and to work in biological laboratories up to BSL3 #LI-remote
Your Profile
You bring a M.Sc. or Ph.D. degree in molecular biology or genomics
You have an extensive practical/laboratory experience of the most frequently used techniques, or at least 2 years as a technical service or field service specialist within a relevant market sector
Your are known for your experience with diagnostic equipment technologies and applications; experience with CRM programs and web-based tools to retrieve and analyze data is a plus
You are a self-starter with the ability to handle and manage multiple tasks in a result-orientated commercial environment and are fluent in English and Finnish; fluency in another European language is a plus.
You like to travel (70%) and bring a valid driver´s license and passport
What we offer
At the heart of QIAGEN are our people who drive our success. We act with passion, always challenging the status quo to drive innovation and continuous improvement. We inspire with our leadership and make an impact with our actions. We create a collaborative, safe and engaging workplace which forms the basis for high performing individuals and teams. We drive accountability and entrepreneurial decision-making and want you to excel your growth and shape the future of QIAGEN.
QIAGEN is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, or disability.
To further strengthen our CMC team, we are looking for a motivated CMC Scientist Early Drug Development. The selected candidate will play a key role in the design and selection of new innovative large molecule drug candidates and will support the development of such candidates towards first in human clinical studies. He/she will work in close concert with internal research teams as well as external development parties. The CMC Scientist brings expertise to drive the development of novel drug candidates and helps to overcome development challenges.
Key Accountabilities and Responsibilities:
Supports the early CMC development of drug candidates including:
– Design lead candidates (in collaboration with Discovery);
– Manufacturability assessment of lead candidates;
– Early stage formulation development;
– Early stage productivity assessment;
– Manufacturing process development;
Development/selection of appropriate analytical methods including potency assay;
Transfers the selected lead candidate to selected third party CDMO;
Supports oversight of IND development track at selected CDMO partners by providing CMC development expert input and expert knowledge of the to be developed drug candidate;
Technical review of CMC documents (e.g. process development protocols/reports, validation protocols/reports, stability protocols/reports, etc.) and batch manufacturing records with minimal
guidance and able to draw appropriate conclusions;
Proactively identify and track project critical path items ‐ identify risks, formulate and monitor
corrective actions;
As a member of the CMC team actively contribute to technical and strategic CMC discussions.
Desired skills & experience:
PhD in chemistry, pharmaceutical sciences, bio‐engineering, or other discipline within pharmaceutical / biotechnology sciences;
Strong technical expertise in the field of biological drug substance and drug product manufacturing, product characterization;
Good understanding of antibody engineering and design of complex proteins;
Able to analyze and synthetize relevant literature and to transfer knowledge to a broader audience;
Good knowledge of ICH and GMP regulations;
Ability to work at the interface between research and development;
Team player with a can do mentality;
Able to operate in a dynamic surrounding of a fast‐growing biotech company with challenging timelines and changing priorities;
Fluent in English, written and spoken.
Offer:
A competitive salary package with extensive benefits
Front seat in the development of therapeutic antibodies
A work environment in a human‐sized, dynamic and rapidly growing biotech company
When you’re part of Thermo Fisher Scientific, you’ll do challenging work, and join a team that values performance, quality and innovation. As part of a successful, growing global organization you will be encouraged to perform at your best. With revenues of more than $40 billion and the largest investment in R&D in the industry, we give our people the resources and chances to create significant contributions to the world.
Location/Division Specific Information
Location: – Remote / Field (Europe)
Division: Genetic Sciences Division – Human Identification (HID)
Discover Impactful Work:
Join us as a Field Applications Specialist (FAS) and assist us in our mission to become the world leader in serving science. This multifaceted position involves providing scientific training, guidance, application support and troubleshooting for our customers in Russian-speaking countries.
A day in the Life:
Deliver on-site and remote scientific application support & training support to our customers on our HID products.
Supporting our customers with the implementation of new products, applications or workflows.
Diagnose & resolve product performance problems and customer queries/complaints by phone, email or onsite.
Work with sales representatives on sales calls to customer laboratories to provide technical and applications assistance in response to customer inquiries.
Assist the regional sales team in the development of accounts by giving technical seminars and presentations that promote the use of our products.
Providing pre-sales support activities like product demonstrations, user meetings or seminars.
Visit and represent our company on scientific or commercial meetings, conferences, trade shows, congresses, etc.
Establish contacts to key opinion leaders in the field and develop local references.
Maintain up-to-date technical expertise and in-depth knowledge of our product portfolio and scientific developments in the forensic DNA-identification workflow.
Become a strong internal Voice of Customer by providing customer feedback on our products to local and European Sales & Marketing.
Build trust with our customers and excel in customer service.
Keys to Success:
Education
Degree in Biology, Biotechnology, Biomedical Sciences, Genetics, Molecular Biology, Biochemistry or similar (Masters or PhD preferred)
Experience
Extensive technical hands-on experience (5 years minimum) in a forensics lab environment such as data analysis and/or research & development.
Previous experience in a support / training-related position or hands-on experience with AB / Thermo Fisher Scientific HID technology is appreciated.
Knowledge, Skills, Abilities
High degree of technical competence & confidence.
Able to connect with and support people optimally with varying levels of technical knowledge and expertise.
Customer-centricity with the emotional intelligence to understand customer concerns and aware of markets, trends and competitors.
Good computer (especially MS Office) and/or IT skills and have an interest for groundbreaking innovation and technology.
Excellent communication & presentation skills.
Fluent Russian and English language skills – oral and written.
Willingness to travel internationally (mainly Russian-speaking countries / CIS with the exception of Russia and Belarus; and within Europe).
Valid driver’s license.
We are offering an employment with an innovative, growing organisation with outstanding career and development prospects and an exciting company culture which stands for integrity, intensity and innovation. The role comes with a competitive salary plan, company pension scheme, bonus plan, company car and further employee benefits.
Our Mission is to enable our customers to make the world healthier, cleaner and safer. Watch as our colleagues explain 5 reasons to work with us. As one team of 100,000+ colleagues, we share a common set of values – Integrity, Intensity, Innovation and Involvement – working together to accelerate research, solve complex scientific challenges, drive technological innovation and support patients in need. #StartYourStory at Thermo Fisher Scientific, where diverse experiences, backgrounds and perspectives are valued.
