Ajankohtaista

Product Marketing Manager – Structural Cell Biology

https://jobs.thermofisher.com/global/en/job/166882BR/Product-Marketing-Manager-Structural-Cell-Biology

The Mission:

You will be a part of the Life Science Business Unit (LSBU) within Material and Structure Analysis Division (MSD) of Thermo Fisher Scientific. The LSBU provides high-value Electron Microscopy workflow solutions for high resolution biological imaging, ranging from atomic resolution imaging of protein complexes to volume acquisition of cellular compartment structures.

The Job:

You will lead and drive product marketing for Structural Physiology. This segmented aims to attract cell biologists with a portfolio ranging from Large volume analysis to the powerful context of Cryo Tomography on whole cells and tissues. You will oversee product development (PMP) execution for products in Life Sciences from a marketing perspective interacting with the Product Development Team. Furthermore, you will contribute to building and executing a strong portfolio roadmap, built on market-focused strategy, deep understanding of product life cycles, and a broad business insight.

What will you do?

• Work with other product managers and marketing managers to establish market requirement documents for structural physiology;
• Develop value proposition, messaging and go-to-market strategies that resonate with the structural physiology segment, based on deep insight in and organizing around customers’ key scientific questions. Define innovative and creative ways to approach new market segments.
• Build external networks e.g. in the context of collaborations: establish and manage technical collaborations with (KOL) customers, track milestones and report out on progress;
• Build internal networks especially with R&D, NanoPort & field applications, marketing teams;
• Drive improvement in product development processes and execution, identify and resolve roadblocks, apply PPI to monitor and continuously improve efficiency and effectiveness of strategy execution;
• Provide support to sales and business development teams, support field escalations through coordinating technical expertise, providing an effective interface with R&D and engaging in technical and scientific discussions with customers.

Who we are looking for:

The successful candidate will possess the following combination of education and experience:

• Typically, a university degree is required, and a PhD/MBA or other advanced degree is preferred, or a combination of education and experience that demonstrate the required skills;
• Typically requires at least 5 years of experience in high-tech product management environment;
• Customer oriented, with a proven ability to build consensus and get buy-in and participation from key stakeholders; strong verbal and written communication skills across all levels and an ability to communicate complex technical concepts to a variety of audiences; fluent in English;
• Proven ability to interact with cross-functional and cross-cultural teams; great team player who thrives in a matrixed organization, is flexible and deals well with dynamic requirements;
• Keen interest in commercial, marketing and business aspects;
• Ability to create a vision for a product, translate it into strategy and execute a value-driven roadmap;
• Ability to travel internationally (up to 30%), and in possession of a valid passport.

Projekti-insinöörin tai bioanalyytikon tehtävä

https://www.utu.fi/fi/yliopisto/tule-meille-toihin/avoimet-tehtavat

Määräaikainen laboratorioinsinöörin, bioanalyytikon tai laboratorioteknikon tehtävä Suomen Funktionaalisen Genomiikan Keskuksessa

 Suomen Funktionaalisen Genomiikan Keskus on ydinpalveluyksikkö, joka kuuluu kansalliseen Biokeskus Suomi infrastruktuuriverkostoon. Tuemme korkeatasoista tutkimusta tarjoamalla avoimen pääsyn viimeisimpiin alan huippua edustaviin teknologioihin ja palveluihin genomiikan alalla. Tällä hetkellä tärkeimmät palvelumme ovat uudensukupolven sekvensointiin perustuvat genomin, transkriptomin ja epigenomin analyysit eri menetelmillä. Palveluidemme käyttäjiä ovat akateemiset yksiköt, valtion tutkimusyksiköt, terveydenhuollon tutkimusyksiköt sekä yritykset. Genomiikan keskus sijaitsee Turun Biotiedekeskuksessa, joka on Turun yliopiston ja Åbo Akademin yhteinen erillislaitos. Toimimme läheisessä yhteistyössä useiden kansainvälisten ja kansallisten sidosryhmien kanssa.

Etsimme nyt tiimimme laboratorioinsinööriä, bioanalyytikkoa tai vastaavaa tukemaan yksikössä tarjottavia tutkimuspalveluita. Avaintehtäviin kuuluu biologisten näytteiden valmistus, laatuanalyysi ja analysointi korkean tehon menetelmillä. Tehtäviin sisältyy myös laitteiden käyttöä ja ylläpitoa sekä prosessin hallintaa yksikössä käytössä olevan laatujärjestelmän mukaisesti. Tehtävät toteutetaan läheisessä yhteistyössä ja vuorovaikutuksessa yksikön muun henkilöstön, palveluiden käyttäjien ja muiden sidosryhmien kanssa. Siksi tehtävän hoitaminen vaatii erinomaisia yhteistyötaitoja, palveluasennetta ja kommunikaatiotaitoja sekä suomeksi että englanniksi. 

Tehtävän hoitaminen edellyttää erinomaisia laboratoriotaitoja, kykyä suurta tarkkuutta ja kärsivällisyyttä vaativaan laboratoriotyöhön, joka on sidottu aikatauluihin. Ydinpalveluyksikkö tarjoaa asiantuntija tukea ja palvelua jatkuvasti kehittyvillä alan huippumenetelmillä. Siksi tehtävä vaatii myös joustavaa ja avointa asennetta sekä motivaatiota oppia jatkuvasti uutta ja kykyä sopeutua nopeisiin muutoksiin ja jatkuvasti kehittyvään tutkimusympäristöön. Tehtävä vaatii myös laatujärjestelmä osaamista, johon tarjotaan myös koulutus. Aiempi kokemus laatujärjestelmästä katsotaan hakijalle eduksi.

Hakijalla tulee olla tehtävään sopiva alan koulutus, kuten bioanalyytikon, insinöörin, kandidaatin tai maisterin tutkinto soveltuvalta alalta. Tehtävän kesto on yksi vuosi kuuden kuukauden koeajalla. Saattaa myös olla, että tehtävälle on tarvetta jatkossa. Palkka määräytyy Suomen yliopistojen työehtosopimuksen mukaisesti. Tehtävä sijoittuu muun henkilöstön henkilöstöryhmään. Riippuen koulutus- ja kokemustasosta sekä muusta osaamisesta palkka on keskimäärin 2200 – 2500 eur / kk.

Otamme vastaan hakemuksia vastaan vuoden 2021 elokuun 30. päivään asti tai kunnes paikka on täytetty. Hakemuksen voi jättää Turun yliopiston elektronisen hakuportaalin kautta:https://www.utu.fi/fi/yliopisto/tule-meille-toihin/avoimet-tehtavat

Lisätietoja antaa tarvittaessa: Riikka Lund, riikka.lund@utu.fi, phone +358 41517 1616, https://bioscience.fi/services/functional-genomics/services/

Doctoral student, the Faculty of Biochemistry and Molecular Medicine

https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=1&id=000011601&lang=fi

We are now looking for a motivated Doctoral student in a project addressing the roles and molecular interactions of collagen XIII (ColXIII) in the neuromuscular junction (NMJ).

Description

Applications are invited for a full-time Doctoral student (max. 4 years) position, starting at the earliest on 1.10.2021 in a research project headed by Professor Taina Pihlajaniemi in the Extracellular matrix & Hypoxia Research Unit, operating at the Faculty of Biochemistry and Molecular Medicine. Molecular and environmental basis for lifelong health is one of the strategic focus areas of the University.  The doctoral student is enrolled in the Health and Bioscience Doctoral Programme of the University of Oulu Graduate school, which provides support in theoretical and practical training.

We are now looking for a motivated Doctoral student in a project addressing the roles and molecular interactions of collagen XIII (ColXIII) in the neuromuscular junction (NMJ). Using murine models we have shown that ColXIII is an essential NMJ component and others have recently shown that mutations in the human gene cause congenital myasthenic syndrome type 19 (CMS19). Using mouse and cell culture models we will identify the network of molecules and the events whereby ColXIII operates in the normal NMJ and the developmental events that lead to CMS19. We will also determine the occurrence of anti-ColXIII autoimmune antibodies in patients with acquired generalized and ocular myasthenia gravis and assess their effects on the NMJ. The studies provide unique opportunities to enhance the understanding of critical motor synapse molecules and facilitate personalized therapies in genetic and acquired myasthenia. The position is fixed-term for 4 years in an Academy of Finland-funded project and it targets to completion of a Doctoral thesis and multiple publications in high-ranked international journals. Besides research, the position includes some teaching duties in an international Master’s Programme in Biochemistry.

Qualification requirements

The successful candidate for the Doctoral student position must possess a M.Sc. degree in the field of biochemistry, molecular or cell biology, medical science or related fields. We also invite applications from pre-graduate students from these fields of university studies. In this case, to be eligible for application, the candidate must demonstrate that he/she will graduate at home University not later than 31.12.2021 and also provide 1) an official statement from the home University attesting that all the courses, exams and other qualifications needed for graduation have already been obtained, 2) an official statement from the home University attesting that thesis has been submitted for evaluation and, 3) a letter of support from the candidate’s Supervisor (the minimum acceptable level for supervision is docent / assistant professor).

Prior experience in molecular biology and cell culture-based experiments is required, and proficiency in microscopy is expected. Prior experience in generating or working with experimental mouse models, and knowledge of the research field in question is considered an advantage. Good communication and teamwork skills are appreciated. Fluency in both written and spoken English is required. Most importantly, we expect the candidate to have a high motivation to conduct high-level biomedical research.

What we offer

We offer a research environment with excellent technological facilities and a motivating and supporting international community at the Faculty of Biochemistry and Molecular Medicine, University of Oulu. We can also offer access to state-of-the-art facilities and special expertise through visits to collaborative laboratories outside Oulu when needed. You will have a place in a highly talented research group, working to solve globally significant research problems. University´s wide variety of support services are at disposal, allowing to focus on studies and research work. The position is fixed-term for 4 years as of 1.10.2021 or as soon as possible thereafter. A trial period of 6 months is applied in the position.

Salary

The initial salary for the new Doctoral student will be based on the demand level 2 of the national salary scale for teaching and research personnel of Finnish universities.  In addition, a salary component based on personal work performance will be paid (maximum of 50 % of the job-specific component) and upgraded based on qualification in research work and progress in PhD studies. In practice, the salary of a new doctoral student will be roughly 2300-2500 € / month before taxes. The salary will be evaluated yearly.

How to apply

Applications, together with all relevant enclosures, must be submitted using the electronic application form by August 15, 2021, at 23:59 (Finnish local time, EEST), with the following attachments as three separate pdf files:

1. Complete CV containing contact information of at least two referees (Max. size limit of the attachment: 5 Mbytes)

2. Motivation letter summarizing professional experience and expertise, reasoning interest in this position and describing career plans (1-2 pages; max. size limit of the attachment: 2 Mbytes).

3. Certificates/Diplomas: Scanned electronic copies of diplomas and transcripts of the records of relevant previous degrees. For the candidates who do not yet hold the M.Sc. degree, please provide: 1) an official statement from the home University attesting that the coming graduation date of the candidate is 31.12.2021 at the latest; 2) an official statement from the home University attesting that all the courses, exams and other qualifications needed for graduation have already been obtained; 3) an official statement from the home University attesting that thesis has been submitted for evaluation and, 4) a letter of support from the candidate’s Supervisor (the minimum acceptable level for supervision is docent / assistant professor). (Max. size limit of the attachment: 2 Mbytes)

Only applications containing all relevant appendices and submitted through the online recruitment system will be considered. Top candidates will be invited to an on-site or remote interview. Applications sent by email will not be considered. The eligible applicants fitting best in the research profile expected for the position may be invited to an on-site or remote interview. All applicants will be notified when the selection process is completed.

Further information

For further information, please contact Prof. Taina Pihlajaniemi, e-mail: taina.pihlajaniemi (at) oulu.fi or Dr. Anne Heikkinen; e-mail: anne.heikkinen (at) oulu.fi

Postdoctoral Researcher, Population Genomics

https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=1&id=000011533&lang=fi

A three-year Postdoctoral Researcher position in Population Genomics is available in the Ant Genomics and Immunity group (https://lumiviljakainen.wordpress.com/).

In this project, funded by the Academy of Finland, we will study genetic underpinnings of convergent evolution of multi-queen colonies (polygyny) in ants. We will investigate genomic architecture and selection across the genomes of monogynous and polygynous ant species using whole-genome sequencing. In addition, immune gene evolution will be studied in these ant societies to decipher whether polygynous lineages have followed similar evolutionary trajectories after convergent evolution.

Open position

• the main duties of the successful candidate are bioinformatics and population genomic analysis of whole-genome sequence data of several ant species and dissemination of research findings
• other tasks include supervision of Ph.D. and M.Sc. students

Qualification requirements:

• Ph.D. in biology, obtained less than 10 years ago
• Experience in population genetics, high-throughput sequence data and bioinformatics
• Ability to work both independently and in a team, and supervise graduate and undergraduate students
• Fluency in both written and spoken English

 What we offer

• We offer you a place in an ambitious research group with excellent international collaborators
• University´s wide variety of support services are at your disposal, allowing you to focus on your research
• In addition to modern research facilities, we offer you personnel benefits such as free occupational healthcare, affordable sport services and endless opportunities to develop your skills and competences
• Regular salary is paid 12 months per year, including paid leave and an additional holiday bonus in the summer
• The successful candidate will also receive benefits provided by the Finnish government to residents, for example possibility to obtain access to the national healthcare system, tax benefits for employees with children and high-quality, affordable childcare services.

Salary

A salary in accordance with the Finnish universities salary system (for teaching and research personnel): level 5. In addition, a salary component based on personal work performance will be paid (maximum of 50% of the job-specific component). Starting gross salary will be approx. 3500€ per month. A trial period of six months is applied in the position.

How to apply

Applications, together with all relevant enclosures, should be submitted using the electronic application form by 30^th of June 2021. The application should be written in English and include the following:

1)     A motivation letter (max. 2 pages) summarizing applicant’s professional experience and expertise and describing why applicant is interested in this position. Also, information on personal research interests, experience and career plan may be provided here

2)     Curriculum vitae (max. 4 pages)

3)     List of publications based on the guidelines of the Academy of Finland: https://www.aka.fi/en/research-funding/apply-for-funding/how-to-apply-for-funding/az-index-of-application-guidelines2/list-of-publications/

4)     Certificates/Diplomas: Scanned copy of the original doctoral degree certificate and transcript of records and, when necessary, official translations to Finnish or English

5)     Contact information of two senior/experienced researchers who may be asked to give a statement on the candidate

Only applications containing all relevant appendices and submitted through the online recruitment system will be considered. Top candidates will be invited to an on-site or remote interview.

Further information

The position is for 3 years starting in September 2021 or as soon as possible thereafter. A trial period of 6 months is applied in the position.

Please contact Dr. Lumi Viljakainen (lumi.viljakainen@oulu.fi) with any questions.

Quality Control (QC) Lab Technician

https://www.recright.com/careers/en/nanoform-finland-oyj/quality-control-qc-lab-technician-60c3483736c0fe5b898dee96

About Nanoform   

Nanoform is an innovative drug particle engineering and nanotechnology company listed on the Premier-segment of Nasdaq First North Growth Market in Helsinki and Stockholm. Nanoform works together with pharma and biotech partners globally to reduce attrition in clinical trials and enhance their molecules’ formulation performance through its nanoforming services. Leveraging our in-house developed AI engine Starmap® we can also predict which customer molecules show most promise for our technology. Nanoform’s capabilities include GMP manufacturing, and its services span the small to large molecule development space with a focus on solving key issues in drug solubility and bioavailability and on enabling novel drug delivery applications.     

Quality Control (QC) Lab Technician  

With the view of developing our organization further, we are now seeking Quality Control Lab Technician to support our quality control team. The position requires availability to integrate shift work regime. The job is located at our facilities in Helsinki, Finland.   

You will be responsible for    

• Ensure that all QC analysis are carried out in an effective and accurate manner according to company standard procedures (SOPs). 
• Implement and develop new methods.
• Maintain and calibrate laboratory equipment.
• Manage reagent, material, and standards stock levels to ensure lab work continuity.
• Ensure that records are done in an accurate manner as per company standards and procedures.
• Support the GMP laboratory activities as per company standard procedures and Quality system. 
• Support current R&D projects by running appropriate analysis and sampling.
• Maintain QC Databases and others relevant for QC operations
• Communicate efficiently with the production and technical teams to discuss QC outcomes and improvements

Ideal experience     

• You have a Bsc or Msc degree in pharmacy, chemistry, microbiology, biotechnology or in an equivalent field. 
• You have been working with biomolecules (especially with proteins).
• Experience from some of the analytical techniques: SDS-PAGE, HPLC-(SEC), immunoassays, DLS.
• Working knowledge of SOPs, Pharmacopeias and GXP Regulations.
• Good technical knowledge and understanding of laboratory procedures, methodology and standards.
• Capacity to work independently in a laboratory environment 
• Capacity to produce clear records and data reports.
• Experience in working in GXP environments. 
• Preferred experience in using electronic Quality systems (LIMS, QMS, CDS, CAPA, others).  
• You are used to work with MS Office programs.

Personal qualities we are looking for 

• You are a doer and have an accurate working style 
• You are flexible in working in a team as well as independently 
• You have an ability to work in a high-performance environment 
• Good English level, both written and spoken   

What we offer to you  

• A great team to join with skilled and highly motivated colleagues
• Encouraging and forward-looking team spirit
• You will be part of a team that invents world-class solutions for the pharmaceutical industry
• We provide extensive learning opportunities. You are able to utilize your skills and competencies widely as we continuously create something new
• We like challenges and want everyone to enjoy solving them together
• Competitive compensation package with broad employee benefits selection

You will get to be part of a unique start-up in the pharma industry.   

Interested?   

To apply for this position, please supply a covering letter and CV by 21st of June, 2021. Please note that we may already start the interviewing process during application period.   

Quality Control Lab Technician

https://www.recright.com/careers/en/nanoform-finland-oyj/quality-control-lab-technician-60c35a7336c0fea0d68df604

About Nanoform 

Nanoform is an innovative drug particle engineering and nanotechnology company listed on the Premier-segment of Nasdaq First North Growth Market in Helsinki and Stockholm. Nanoform works together with pharma and biotech partners globally to reduce attrition in clinical trials and enhance their molecules’ formulation performance through its nanoforming services. Leveraging our in-house developed AI engine Starmap® we can also predict which customer molecules show most promise for our technology. Nanoform’s capabilities include GMP manufacturing, and its services span the small to large molecule development space with a focus on solving key issues in drug solubility and bioavailability and on enabling novel drug delivery applications.   

Quality Control (QC) Lab Technician  

With the view of developing our organization further, we are now seeking Quality Control Lab Technician to support our quality control team. The position requires availability to integrate shift work regime. The job is located at our facilities in Helsinki, Finland.   

 You will be responsible for    

• Ensure that all QC analysis are carried out in an effective and accurate manner according to company standard procedures (SOPs). 
• Implement and develop new methods.
• Maintain and calibrate laboratory equipment.
• Manage reagent, material, and standards stock levels to ensure lab work  continuity.
• Ensure that records are done in an accurate manner as per company standards and procedures.
• Support the GMP laboratory activities as per company standard procedures and Quality system. 
• Support current R&D projects by running appropriate analysis and sampling.
• Maintain QC Databases and others relevant for QC operations
• Communicate efficiently with the production and technical teams to discuss QC outcomes and improvements 

Ideal experience     

• You have a Bsc or Msc degree in pharmacy, chemistry, microbiology, biotechnology or in an equivalent field. 
• Working knowledge of SOPs, Pharmacopeias and GXP Regulations.
• Good technical knowledge and understanding of laboratory procedures, methodology and standards.
• Experience in all or some of the following analytical techniques: HPLC, UPLC, DSC, XRPD, Laser Diffraction, DLS, Karl Fisher, FTIR, SEM, AFM.
• Capacity to work independently in a laboratory environment 
• Capacity to produce clear records and data reports.
• Experience in working in GXP environments. 
• Preferred experience in using electronic Quality systems (LIMS, QMS, CDS, CAPA, others).  
• You are used to work with MS Office programs.

Personal qualities we are looking for 

• You are a doer and have an accurate working style 
• You are flexible in working in a team as well as independently 
• You have an ability to work in a high-performance environment 
• Good English level, both written and spoken   

What we offer to you  

• A great team to join with skilled and highly motivated colleagues
• Encouraging and forward-looking team spirit
• You will be part of a team that invents world-class solutions for the pharmaceutical industry
• We provide extensive learning opportunities. You are able to utilize your skills and competencies widely as we continuously create something new
• We like challenges and want everyone to enjoy solving them together
• Competitive compensation package with broad employee benefits selection

You will get to be part of a unique start-up in the pharma industry.     

We are looking forward to hear from you!

To apply for this position, please supply a covering letter by 21st of June,2021.

Please note that we may already start the interviewing process during application period.   

Early Stage Researcher, Molecular Biology

https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=16&id=000011543&lang=fi

The University of Eastern Finland is inviting applications for an Early Stage Researcher in Molecular Biology – position in Joensuu campus. The position will be filled for a period of four year starting from September 1, 2021. Please find more information below and submit your application no later than 3 August 2021. 

Role and salary

The research project, funded by the Academy of Finland, aims to understand the processing of stalled mitochondrial DNA (mtDNA) replication forks, their relation to mtDNA integrity and cellular signalling responses. The PhD student will investigate the role of two proteins in the cleavage of stalled mitochondrial replication forks, the fate of broken mtDNA in cells and the signalling pathways that react to mtDNA damage or interact with extramitochondrial mtDNA.

Positions of Early Stage Researchers shall always be filled for a fixed term (UEF University Regulations, Section 31). The position will be filled for a period of four year starting from September 1, 2021. A probationary period is applied to all new members of the staff.

The salary of the position is based on the salary system for the teaching and research staff at universities. The salary consists of the job-related salary element and the personal performance salary element. For this position, the job requirement level used to determine the job-related salary element is 2–4, and the personal performance salary element is 6–50% of the job-related salary element. The estimated monthly salary in the beginning of the employment will be 2,288.17- 3,163.95 €/per month. The salary of an early stage researcher depends on the phase of the doctoral dissertation and postgraduate studies as well as personal performance.

As Early Stage researcher your main responsibilities will include:

• Manipulation of enzymes involved in mtDNA maintenance using siRNA knockdown, CRISPR/Cas9-knockout and induced overexpression in cultured cells
• Analysis of mtDNA replication intermediates and stalled replication forks using agarose electrophoresis and transmission electron microscopy
• Investigation of the signalling pathways affected by mtDNA damage or mtDNA escape from mitochondria by Western blots, inhibitors and knockdown of key components
• Research visits to collaboration laboratories
• Presenting of research results in international conferences and publishing results
• Writing of a Ph.D. thesis

Our requirements and expectations

A person to be appointed as an Early Stage Researcher shall be qualified to pursue postgraduate studies, i.e. he or she is required to have completed a suitable higher university degree or an equivalent education abroad, which in the country in question would qualify the person for similar academic studies. A master’s degree or equivalent in molecular biology, cell biology, biochemistry or a related field is required for the position. Persons graduating in the near future are also encouraged to apply. However, they are expected to hold a relevant M.Sc. degree (or equivalent) by the starting date of the Early Stage Researcher position.

Potential candidate should have good command of the English language. We expect the student to have good prior knowledge of molecular biology methods and cell culture. Previous experience with mitochondria or mitochondrial DNA metabolism is a plus.

Your benefits
You will have access to the university’s staff benefits, including

• extensive occupational health care
• staff discount on lunch in our campus restaurants, as well as on a range of other services
• affordable sports services. 

Please read more in the Work at UEF section on our website.

You will have an opportunity to work in an interesting role as part of our international, creative, participatory and inclusive academic community.

How to apply?

Submit your application by using our electronic application form no later than 3 August 2021 (by 24.00 hours Finnish time). 

Please note that you must include the following appendices in your application:

• CV (max 2 pages http://www.tenk.fi/en/template-researchers-curriculum-vitae including possible publications)
• a motivational letter and the contact details for one or two references
• copies of your academic degree certificates / diplomas, and copies of certificates / diplomas relating to your language proficiency, if not indicated in the academic degree certificates/diplomas 

Questions?

For further information on the position, please contact Senior Researcher Jaakko Pohjoismäki, Ph.D., tel. +358 29 445 3052, jaakko.pohjoismaki@uef.fi.

For further information on the application procedure, please contact Executive Assistant Satu Turunen, tel. +358 29 445 3031, satu.turunen@uef.fi (on vacation July 3- July 30). 

Post-doc­to­ral re­searc­hers and/​or PhD-stu­dents in cell bio­lo­gy and stem cell bio­lo­gy

https://www2.helsinki.fi/fi/avoimet-tyopaikat/post-doctoral-researchers-andor-phd-students-in-cell-biology-and-stem-cell-biology

The HiLIFE – Institute of Biotechnology (BI), located in the Viikki science park, is a research institute at University of Helsinki. The institute harbors ~35 research groups and 250 researchers, and it operates at the highest international level. For more information on the Institute, please visit https://www.helsinki.fi/en/hilife-institute-of-biotechnology.

The laboratory of Dr. Jette Lengefeld is inviting applications for post-doctoral researchers and/or PhD-students in cell biology and stem cell biology.

The failure to regenerate tissue with age is a major health issue. A contributor to this decline is the loss of stem cell function. Despite the essential role of stem cells, it is still unclear how they fail to maintain their functions during ageing and disease. We discovered a new aspect of stem cell ageing in vivo: cellular enlargement. With age and damage, stem cells increase in size causing their functional decline. However, we are only beginning to understand how size impacts stem cell fitness and the physiological importance of this process remains unsolved.

The Lengefeld research group uses blood (hematopoietic) stem cells from mice and human bone marrow donations to address these fascinating questions:

• What pathways cause stem cell dysfunction during their enlargement?
  We use blood (hematopoietic) stem cells of mouse models to identify the molecular mechanisms impairing fitness of large stem cells from a metabolic perspective.
• Can we rejuvenate stem cells after aging and damage?
  We explore approaches to rejuvenate stem cells and investigate the effects on cellular ageing and organismal health.
• Does deregulation of size lead to cancer?
  We utilize blood stem cells from mice and humans to identify factors that facilitate leukaemia in vivo and to investigate the underlying mechanisms.

The post-doctoral applicants should hold PhD in cell biology, stem cell biology, cell size regulation or a related field. Strong expertise in stem cell biology and experience working with mice is highly beneficial. The PhD-student applicants should obtain MSc or related degree in the biology field latest by August 2022, and have a strong interest to carry out cutting-edge research. The positions will provide multiple opportunities for collaborations with potential lab visits abroad. An attitude to drive own research and work in an intra and inter team fashion is highly appreciated. In return, the candidates are offered an access to a wide variety of methodologies and advanced techniques. The working language of the laboratory, the BI and HiLIFE is English and good communication skills in English are required.

The postdoctoral researcher and PhD-student positions are initially limited to 2 and 4 years, respectively, with a possibility of extension. A trial period of 6 months will be applied, and the salaries will be based on the University salary scheme for teaching and research personnel composed of both task specific and personal performance components.

Application should include the following documents as a single pdf file: CV, list of publications, motivation letter including a description of your research interests, and the names and telephone numbers of at least two referees.

Please submit your application, together with the required attachments, through the University of Helsinki electronic recruitment system by clicking the “Apply for the position” – link below. Applicants employed by the University of Helsinki must submit their application through the SAP HR portal.

The deadline for the applications is 8th of July 2021, but the positions will be filled immediately once suitable candidates have been identified.

For informal inquiries, contact ‘jette.lengefeld(at)helsinki.fi’, and for more information about our research, please visit https://www2.helsinki.fi/en/hilife-institute-of-biotechnology/research/c…

For technical support regarding the recruitment system, please contact rekrytointi@helsinki.fi.

(Senior) Scientist Radiopharmacy and in vivo pharmacology

https://duunitori.fi/tyopaikat/tyo/senior-scientist-radiopharmacy-and-in-vivo-pharmacology-scsom-13129204?utm_source=loimu&utm_medium=site

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

IMPORTANT: In order to be considered for this position, a resume/CV must be uploaded and submitted during the application process. Please make sure work history and education are added correctly.

Job Summary

We are looking for a motivated proactive and self-driven (senior) scientist (position depends on experience) to join Charles River Discovery Research Service site located in Kuopio, Finland The position requires proven track of experience in radiopharmaceutical science for in vivo oncology or neuroscience and expertise in in vivo pharmacological studies. The candidate will be part of a multi-disciplinary preclinical research team and will report to Principal Scientist In Vivo.

The person in this role will operate in a highly collaborative environment, partnering with peers, operational teams (in vivo, Imaging, Biomarker) at the site and Clients. In this position you will be leading Client projects in CNS/oncology drug discovery field ensuring the scientific excellence of study design, execution, data analysis and reporting. The candidate will help to set program/study strategies and provide steps forward based on the outcomes.

In addition to Client studies, scientist will be involved in R&D activities including validations of new assays, models and techniques to support capabilities portfolio of the Company and specific Client’s needs.

Job Qualifications

*

• Higher education degree in relevant subject, e.g. biomedical science (MSc) with 3+ years of experience, preferably PhD degree
• Pharmaceutical industry, Preclinical Contract Research Organization or academic post-doctoral experience will be an asset
• Experience on radiopharmaceutical preparation (radiolabeling) for nuclear imaging is required
• Proven expertise in utilizing in vivo models and assays for pharmacological studies in neuroscience and/or oncology is required

• Hands on experience in development, optimization and validation of PET/SPECT/CT imaging in preclinical environment is required
• Experience in receptor affinity techniques such as radioligand binding or autoradiography will be an asset
• Ability to independently design, develop and implement chromatography (SEC, HPLC) methods will be an asset
• Proven ability to work in a team or collaboration-based environment
  • Excellent analytical, organizational and communication skills

• Problem solving skills and effective decision making
• Ability to lead, coordinate and prioritize and get things done
• Ability to work flexibly across projects and adapt to new priorities in fast-paced environment
• Fluent spoken and written English, scientific writing skills

IMPORTANT: A resume is required to be considered for this position. If you have not uploaded your resume in your candidate profile, please return to upload field and attach your resume/CV.

About Discovery
Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 320 patents and 74 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.

About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.

With over 18,000 employees within 100 facilities in 24countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2019, revenue increased to $2.62 billion.

At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~85% of the drugs approved by the FDA in 2019.

For more information, please visit www.criver.com.

Erikoistutkijan ma. tehtävä: mikrobiomitutkimuksen bioinformatiikka

https://www.utu.fi/fi/yliopisto/tule-meille-toihin/avoimet-tehtavat

Turun yliopisto on maailmanluokan monialainen tutkimusyliopisto, joka tarjoaa haasteellisia työtehtäviä ja ainutlaatuisen näköalapaikan suomalaiseen ja kansainväliseen tiede- ja koulutusmaailmaan. 

Turun yliopiston Tietotekniikan laitos hakee erikoistutkijaa määräaikaiseen tehtävään mikrobiomitutkimuksen bioinformatiikan alalle 1.9.2021-28.2.2025. Hankkeessa kehitetään ja sovelletaan uusia bioinformatiikan menetelmiä ajankohtaiseen mikrobiekologian ja metagenomiikan tutkimukseen osana kansainvälistä yhteistyöverkostoa. Tutkimustyön lisäksi työtehtävät voivat sisältää muita tehtäviä, kuten hankkeen koordinointia, kurssien ja tapahtumien järjestämistä, opinnäytetöiden ohjausta ja muuta opetusta. Työ tehdään apulaisprofessori Leo Lahden tutkimusryhmässä Tietotekniikan laitoksella.

Odotamme itsenäisyyttä, analyyttisiä valmiuksia, erinomaista opintomenestystä, yhteistyökykyä, ja motivaatiota työskennellä monitieteisessä ympäristössä. Sopiva hakija on juuri valmistunut tai viimeistelemässä tohtorintutkintoa soveltuvalta alalta ja omaa julkaisuin osoitettua näyttöä alan menetelmien ja tutkimuskysymysten hallinnasta. Kokemus yritysyhteistyöstä katsotaan eduksi. Sujuva suomen ja englannin kielen taito ovat välttämättömiä.

Tehtäväen kelpoisuusvaatimuksista on säädetty Turun yliopiston johtosäännössä: https://www.utu.fi/fi/yliopisto/organisaatio 

Erikoistutkijan tehtävään otettavalta edellytetään tohtorin tutkintoa ja kykyä itsenäiseen tieteelliseen työhön. Tehtävärakenteen toiselle portaalle sijoittuvaan erikoistutkijan tehtävään voidaan ottaa myös ylemmän korkeakoulututkinnon suorittanut henkilö, jolla on erityisen hyvä käytännöllinen perehtyneisyys tehtäväalaan.

Erikoistutkijan palkkaus määräytyy yliopistojen palkkausjärjestelmän opetus- ja tutkimushenkilöstön vaativuustasokartan tasojen 4-6 mukaisesti, jossa tehtäväkohtainen palkanosa on 2591,28–3498,98 euroa kuukaudessa. Lisäksi tehtävässä maksetaan henkilökohtaiseen suoriutumiseen perustuvaa palkanosaa, joka on 6% – 50% tehtäväkohtaisesta palkasta.

Tehtävässä on kuuden (6) kuukauden koeaika.

Hakemus tulee jättää viimeistään keskiviikkona 2.6.2021 (23:59) yliopiston sähköisessä rekrytointijärjestelmässä.

Linkki järjestelmään on ilmoituksen alussa kohdassa (”Täytä hakemus”). Ilmoitus on luettavissa osoitteessa: www.utu.fi/tyopaikat 

Hakemukseen tulee sisällyttää:
1)      motivaatiokirje (1 sivu)
2)      ansioluettelo (1-4 sivua)
3)      julkaisuluettelo
4)      tutkintotodistukset
5)      opintorekisteriote

Lisätietoa tehtävästä antaa apulaisprofessori Leo Lahti, leo.lahti@utu.fi