Solubiologi-lehden toimituskunta piti vuosittaisen kokouksensa 1.2.2019 Turussa. Tehokkaan parituntisen aikana ideoitiin päätoimittaja Jenny Joutsenen johdolla mm. lehden sisältöön ja ulkoasuun liittyviä uudistuksia, jotka tulette näkemään vielä tämän vuoden aikana. Paljon uutta on tulossa!
Faculty of Sport Sciences, University of Jyväskylä (JYU) in collaboration with the Institute for Molecular Medicine Finland (FIMM), University of Helsinki (UH) is seeking outstanding PhD student candidates in gerontology starting in March 2019, or by agreement (https://www.jyu.fi/sport/en/phd-student-candidate-position-available-in-gerontology ).
The Juho Vainio Foundation funded project ”The Role of Lifestyles, Socio-economic and Prosperity of Childhood and Youth in Biological Aging” is led by University Researcher Dr Elina Sillanpää. The project is based on the Finnish twin cohort and the Estrogen, Menopause and Functional Ability (ERMA) research material with epigenetic clocks for biological age available.
The Doctoral Student is responsible for carrying out the thesis related work and reporting of the findings in scientific journals, and completion of the studies required for the Doctoral Thesis. The work will be supervised by the project leader Dr Elina Sillanpää, JYU, and Academy Research Fellow Miina Ollikainen, FIMM, UH. During the four years of doctoral training, the PhD candidate is expected to work in both the Faculty of Sport Sciences at the University of Jyväskylä and the Institute for Molecular Medicine Finland at the University of Helsinki.
Qualifications and experience:
Candidates are expected to have a second cycle academic degree (MSc, MD or equivalent) in statistics, bioinformatics, sports sciences, health sciences, biotechnology, molecular biology, computer science, mathematics, medicine, or other related fields. Experience in laboratory work and/or statistical modelling and methods is highly appreciated. The successful candidate will have good problem solving, troubleshooting, and analytical skills.
The selected person must fulfill the qualifications for Doctoral studies set by JYU, and apply for study right from the Faculty of Sport and Health Sciences, JYU. Doctoral Students are required to have a good command of the English language. Proficiency in Finnish is required for teaching and research positions of the University of Jyväskylä. However, according to Finnish law, a non-native university teaching and research staff member may be granted an exemption from the Finnish language proficiency requirement. Students who are finalizing their master’s studies are also permitted to apply.
The Doctoral student will first start on a research grant (1900€/month, including statutory pension insurance). The length of the grant period is negotiable. After a successful review of the PhD plan, an official appointment to a Doctoral Student position at the University of Jyväskylä will be made. The Doctoral Student’s salary is based on the salary system for teaching and research staff at Finnish universities. At the moment funding can be guaranteed for the first three years of PhD work.
To apply, applicants should submit the following materials prepared in English or Finnish:
Candidates are invited to submit their application to Elina Sillanpää, PO Box 35 (VIV) 40014 University of Jyväskylä at no later than February 15th 2019.
For further information of the position, please contact Elina Sillanpää, elina.sillanpaa@jyu.fi or Miina Ollikainen, miina.ollikainen@helsinki.fi.
For further information, visit
Open position for a PhD student within the Collaborative Research Centre (CRC)1371 in “Diet – gut microbiota – lipid metabolism – intestinal cancer” (m/f/d) starting as soon as possible.
The gut microbiome plays a fundamental role in health and disease. CRC 1371 (Speaker Prof. Dr. Dirk Haller) focuses on the digestive tract and proposes an interdisciplinary approach to characterizing the functional relevance of microbiome signatures in the context of inflammation and cancer. Within CRC 1371, the Integrated Research Training Group (IRTG) provides a qualification program for PhD students containing excellent multidisciplinary training with tailor-made subject-based and soft skills courses, annual retreats, summer school, and a supervision concept.
Job description
“Impact of dietary fat-gut microbiota interaction on intestinal lipid
absorption, systemic lipid metabolism and intestinal cancer”
Variation in dietary fat and gut microbiota affect intestinal lipid resorption, systemic lipid metabolism and energy balance. Excess dietary fat intake promotes positive energy balance, fat accretion and obesity, which is a significant risk factor for colorectal cancer. The aim of this project is to reveal the role of dietary fat – microbiota interaction on host lipid metabolism under physiological and patho-physiological conditions. Wildtype and Apc1638N germ-free (GF), Oligo-MM and specific pathogen-free (SPF) receiving different diets will be tested for differences in lipid metabolic processes.
The effects of microbiota and dietary fat on energy balance will be assessed in mouse models. This includes calorimetric methods to measure energy intake, energy excretion and intestinal absorption efficiency, but also energy expenditure and metabolic fuel selection. To gain mechanistic insights, untargeted and targeted lipidomics will be applied to identify bioactive lipids (microbiota-, diet- and host-derived) and test their functional relevance. Taken together, the aim of the project is to define diets and gut microbiota communities beneficial in the suppression of obesity-driven metabolic diseases and intestinal cancer.
Related publication: Kübeck R, et al. Dietary fat and gut microbiota interactions determine diet-induced obesity in mice. Mol Metab. 2016 Oct 13;5(12):1162-1174.
Techniques/methods to be applied include:
More information and application at https://portal.mytum.de/jobs/wissenschaftler/NewsArticle_20190122_223956/newsarticle_view
The labs of Siobhan Brady (Dept. of Plant Biology and Genome Center) and David Segal (Dept. of Biochemistry and Molecular Medicine, School of Medicine, Genome Center) at the University of California, Davis are recruiting a postdoctoral scholar, starting immediately. In this project, funded by the USDA and the BBSRC, the postdoctoral scholar will use synthetic biology to create targeted mutations in promoters of genes involved in regulation of nitrogen metabolism in both Arabidopsis and tomato. In addition, the postdoctoral scholar will engineer readers and writers associated with epigenetic modification of DNA in order to silence gene expression within the context of a metabolic regulatory logic.
Salary: Commensurate with qualifications, experience, and prevailing salary scale.
Application deadline – February 15, 2019 or until filled.
Required
· PhD in Molecular Biology, Genetics, Plant Biology or related field
· Extensive experience with molecular biology and cloning
· Experience with CRISPR-Cas9
· A strong publication record
· Excellent writing and communication skills
· Ability to work independently and to work well with others
· Ability to work on an international interdisciplinary team
Recommended
· Experience with plant transformation
· Experience with programming (R, Python or other)
· Experience with statistical analyses
Cover Letter describing relevant experience and interests, CV, and contact information for 3 references to sbrady@ucdavis.edu
Post-doctoral and pre-doctoral scientist for research project linked to Natural Killer cell therapy in the Finnish Red Cross Blood Service, Helsinki, Finland
https://www.veripalvelu.fi/meille-toihin/avoimet-tyopaikat/project-scientists
Finnish Red Cross Blood Service is a non-profit organisation responsible for collecting blood and supplying blood products all over Finland in a centralised manner, with the annual turnover of about 65 million €. The FRC Blood Service provides all histocompatibility testing for clinical transplantation in Finland and has active programs in cell therapy; for example, it has produced therapeutic MSC-cells to over 60 patients. We have a research budget of over 3 million €, with the focus areas in cell therapies, blood donors and genomics of transplantation. Over 60 PhD theses have been completed in the Blood Service and every year 20-30 peer reviewed scientific papers are published by our scientists.
Finnish Red Cross Blood Service, together with University hospitals of Helsinki and Turku, has started a project aiming to Natural Killer (NK) cell therapy for e.g. relapse of malignant diseases after stem cell transplantation. We are now looking for a post-doctoral scientist and pre-doctoral scientist to a research project supporting the therapy approach. The primary goals are related to identification of preferential patient groups for NK therapy and molecular characterization of NK cell product.
We assume good skills in immune cells and data-analysis. The positions can be fulfilled immediately and are primarily funded by the state VTR-funding and by the Cancer Foundation (Syöpäsäätiö). Post-doctoral position will be initially for two years and pre-doctoral for one year and may be extended depending on funding.
Please send your application, including a short CV, by February 15th via this link.
For more information, please contact Erja Kerkelä (erja.kerkela@veripalvelu.fi) or Jukka Partanen (jukka.partanen@veripalvelu.fi).
Tehtäväsi on diagnostiikkatuotteidemme myynti ja tuotetuki. Sinulla on avainasiakasvastuu (KAM), jossa teet yhteistyötä muiden spesialistiemme kanssa. Odotamme luonnontieteellisen (FM) tai laboratorioalan koulutuksen lisäksi myyntihenkisyyttä ja -kokemusta ja valmiutta kotimaan matkapäiviin.
Tarjoamme erinomaiset tuotteet, hyvän tuotekoulutuksen myös tehtailla sekä mukavaksi tunnetun työyhteisön tuen kilpailukykyisin eduin.
Lähetä vapaamuotoinen CV ja vapaamuotoinen hakemus palkkatoiveineen 11.2.2019 mennessä osoitteella hakemukset.turku@pomona.fi
Annan mielelläni lisätietoja!
Jarmo Laakkonen, Toimitusjohtaja
Parhaiten tavoitat minut 28.1. klo 13-15.00 tai 7.2. klo 13-15.00
puh. 040 9002952
Mikroskopian (Leica Microsystems) myyjänä tarjoat ratkaisuja mm. teollisuuteen, viranomaisille (rajavartiosto ja KRP), kouluihin, museoille jne. Olet innokas paneutumaan asiakkaidemme tarpeisiin ja myös tekemään tulosta. Tiedät kokemuksesta, mitä myyntityö on ja koet sen omaksesi. Koulutuksesi on todennäköisesti tekninen (ins, AMK-ins tai DI).
Tarjoamme erinomaiset tuotteet, hyvän tuotekoulutuksen myös tehtailla sekä mukavaksi tunnetun työyhteisön tuen kilpailukykyisin eduin.
Lähetä vapaamuotoinen CV ja vapaamuotoinen hakemus palkkatoiveineen 11.2.2019 mennessä osoitteella hakemukset.turku@pomona.fi
Annan mielelläni lisätietoja!
Pekka Sulonen, Myyntipäällikkö
Parhaiten tavoitat minut 29.1. tai 30.1. klo 13-16.00, puh. 040 543 2317
Post-doctoral; 24 months (starting in March/April 2019), Strasbourg, France
Title: New targets and pathways in neuroprotection.
PROJECT: The project aims at identifying mechanisms of neurodegeneration with the main focus on small bioactive molecules, which deficits were observed during aging and further exacerbated in several neurodegenerative diseases including Alzheimer or Parkinson disease. Such bioactive molecules may act as ligands for transcription factors and are important for adaptive reprogramming of the organism, but their study is impeded due to lack of appropriate tools. We propose to use newly developed bioprobes to visualize such molecules and study their intracellular traffic between cellular organelles and its relevance for cell physiology and pathology. The same tools will be also employed to study blood-brain-barrier transfer and inter-cellular traffic of such molecules as mechanisms underlying adaptive processes and activity-dependent cellular communication. Studies will be carried out in mouse brain tissue preparations, organotypic and primary cell cultures using in vivo imaging and if necessary high-resolution imaging. Particular attention will go to neuron-neuron and neuron-astrocyte-microglia circuits.
We are looking for highly motivated post-doctoral fellow, with good English level and background in cellular biology and cellular communication. Sound experience in confocal imaging is required, whereas knowledge of life imaging techniques will be useful. Similarly, good knowledge of primary or cell culture techniques is necessary whereas experience with organotypic cultures will be useful. Although any technical expertise in molecular biology can be acquired in the team, any previous experience in these techniques will be of benefit. The candidate should be willing to bring personal input to the challenging multidisciplinary project, write scientific papers, contribute to preparation of research grants and participate in animating team’s life. The project will be carried out at IGBMC, Strasbourg, which lies in heart of dynamic tri-national region of Alsace and will benefit from proximity and collaborations with research teams in Basel and Freiburg.
Applicants should submit their complete application file (CV, motivation letter, publication list and contact to at least two reference scientists in one PDF file) by email.
Contact information:
Dr Wojciech Krezel (Research Director at INSERM)
IGBMC, 1, rue L.Fries, 67404 Illkirch (CU Strasbourg), France
email: krezel@igbmc.fr
Post-doctoral; 24 months (starting in March/April 2019), Strasbourg, France
Title: Role of retinoid signaling in the physiology and pathology of basal ganglia
The project:
Several lines of evidence indicate that retinoid signaling, best known for its developmental functions, is also critical for homeostasis and neuroprotection of adult nervous system. In particular, abnormal signaling of some retinoid receptors is associated with Huntington or Parkinson diseases and may contribute to their physiopathology whereas point mutations of such receptor(s) are causal factors of rare neurological disorders. The project aims at characterizing the mechanisms through which deficient or excessive retinoid signaling may contribute to neurodegeneration. The project will take advantage of classical and new genetic mouse models of neurodegenerative diseases and will involve genomic and functional studies in primary organotypic or neural cell cultures as well as in vivo analyses in mice with final objective to propose new therapeutic targets and strategies of treatment. The project will be carried out at IGBMC (Strasbourg-Illkirch), an international research institute located in the heart of dynamic research region at crossroads of France, Germany and Switzerland. It will benefit from state-of-the-art infrastructure and international collaborations which include world clinical experts in neurology.
We are looking for highly motivated post-doctoral fellow with solid research experience in molecular and cellular neurobiology (experience in primary mammalian cell and/or organotypic cultures will be very useful). Experience in mitochondrial biology and calcium signaling will be of great asset. The ability to work in an English speaking team and good communication skills are required. The ideal candidate should be able to bring original input to the 2 year challenging project, write papers and projects, and participate in animating team’s life.
Applicants should submit their complete application file (CV, motivation letter, publication list and contact to at least two reference scientists) in one PDF file by email.
Contact information:
Dr Wojciech Krezel (Research Director at INSERM)
IGBMC, 1, rue L.Fries, 67404 Illkirch (CU Strasbourg), France
email: krezel@igbmc.fr
Suomen Solubiologit ry:n hallitus on suunnitellut kovasti 45-v juhlavuoden seminaaria. Järjestelyt rupeavat olemaan oikein erinomaisella mallilla, ja olemme hyvin innoissamme tulevasta tapahtumasta! Lisätietoa tulossa pian, stay tuned!
Meitä Orionilaisia on 3200 yli 20 maassa ja työskentelemme hyvinkin erilaisissa tehtävissä. Joukostamme löytyy niin tutkijoita ja laborantteja kuin insinöörejä ja IT-asiantuntijoitakin sekä tuotantotyöntekijöitä ja monia muita. Tarjoamme työntekijöillemme monipuolisia sekä vastuullisia tehtäviä aidosti monialaisessa ympäristössä. Kannustamme oman osaamisen kehittämiseen ja tarjoamme mahdollisuuden vaikuttaa työtehtäviin ja oman urapolun luomiseen Orionilla. Me etsimme oman alansa huipputekijöitä, jotka jakavat aidon innostuksemme siihen, mitä teemme. Tutustu Orioniin tarkemmin >>
Haemme laboratorioassistenttia määräaikaiseen työsuhteeseen Molecular Profiling -yksikköön. Molecular Profiling -yksikkö vastaa Orionilla kehitettävien pienmolekyylien ja biologisten lääkeaineiden teho-, turvallisuus-, metabolia ja formulaatioseulonnasta.
Tehtäviisi kuuluu nisäkässoluviljelmien ylläpito, nisäkässolujen valmistelu ja maljaus seulontatesteihin, nisäkässolujen tai kudosnäytteiden altistus testattaville aineille ja testien analyysit mittalaiteilla. Tehtävään valittavan henkilön tulee myös pystyä valmistelemaan mittalaitedata ja tehdä alustava analyysi tulosten laadun tarkkailua varten.
Tehtävässä menestyminen edellyttää käytännön kokemusta:
Arvostamme myös kokemusta entsymaattisista in vitro menetelmistä ja MS Office –ohjelmien, kuten Excel ja Word, hallintaa.
Lisätietoja tehtävästä saat Mikko Karjalaiselta numerosta 0104265849 seuraavina aikoina:
16.1. klo 14-15
18.1. klo 13-14
22.1. klo 13-14
25.1. klo 10-11Tehtävään valitulta henkilöltä edellytetään hyväksyttyä terveystarkastusta, joka sisältää myös huumausainetestauksen.P