Post-doctoral positions in Strasbourg, France
22.1.2019Post-doctoral; 24 months (starting in March/April 2019), Strasbourg, France
Title: New targets and pathways in neuroprotection.
PROJECT: The project aims at identifying mechanisms of neurodegeneration with the main focus on small bioactive molecules, which deficits were observed during aging and further exacerbated in several neurodegenerative diseases including Alzheimer or Parkinson disease. Such bioactive molecules may act as ligands for transcription factors and are important for adaptive reprogramming of the organism, but their study is impeded due to lack of appropriate tools. We propose to use newly developed bioprobes to visualize such molecules and study their intracellular traffic between cellular organelles and its relevance for cell physiology and pathology. The same tools will be also employed to study blood-brain-barrier transfer and inter-cellular traffic of such molecules as mechanisms underlying adaptive processes and activity-dependent cellular communication. Studies will be carried out in mouse brain tissue preparations, organotypic and primary cell cultures using in vivo imaging and if necessary high-resolution imaging. Particular attention will go to neuron-neuron and neuron-astrocyte-microglia circuits.
We are looking for highly motivated post-doctoral fellow, with good English level and background in cellular biology and cellular communication. Sound experience in confocal imaging is required, whereas knowledge of life imaging techniques will be useful. Similarly, good knowledge of primary or cell culture techniques is necessary whereas experience with organotypic cultures will be useful. Although any technical expertise in molecular biology can be acquired in the team, any previous experience in these techniques will be of benefit. The candidate should be willing to bring personal input to the challenging multidisciplinary project, write scientific papers, contribute to preparation of research grants and participate in animating team’s life. The project will be carried out at IGBMC, Strasbourg, which lies in heart of dynamic tri-national region of Alsace and will benefit from proximity and collaborations with research teams in Basel and Freiburg.
Applicants should submit their complete application file (CV, motivation letter, publication list and contact to at least two reference scientists in one PDF file) by email.
Contact information:
Dr Wojciech Krezel (Research Director at INSERM)
IGBMC, 1, rue L.Fries, 67404 Illkirch (CU Strasbourg), France
email: krezel@igbmc.fr
Post-doctoral; 24 months (starting in March/April 2019), Strasbourg, France
Title: Role of retinoid signaling in the physiology and pathology of basal ganglia
The project:
Several lines of evidence indicate that retinoid signaling, best known for its developmental functions, is also critical for homeostasis and neuroprotection of adult nervous system. In particular, abnormal signaling of some retinoid receptors is associated with Huntington or Parkinson diseases and may contribute to their physiopathology whereas point mutations of such receptor(s) are causal factors of rare neurological disorders. The project aims at characterizing the mechanisms through which deficient or excessive retinoid signaling may contribute to neurodegeneration. The project will take advantage of classical and new genetic mouse models of neurodegenerative diseases and will involve genomic and functional studies in primary organotypic or neural cell cultures as well as in vivo analyses in mice with final objective to propose new therapeutic targets and strategies of treatment. The project will be carried out at IGBMC (Strasbourg-Illkirch), an international research institute located in the heart of dynamic research region at crossroads of France, Germany and Switzerland. It will benefit from state-of-the-art infrastructure and international collaborations which include world clinical experts in neurology.
We are looking for highly motivated post-doctoral fellow with solid research experience in molecular and cellular neurobiology (experience in primary mammalian cell and/or organotypic cultures will be very useful). Experience in mitochondrial biology and calcium signaling will be of great asset. The ability to work in an English speaking team and good communication skills are required. The ideal candidate should be able to bring original input to the 2 year challenging project, write papers and projects, and participate in animating team’s life.
Applicants should submit their complete application file (CV, motivation letter, publication list and contact to at least two reference scientists) in one PDF file by email.
Contact information:
Dr Wojciech Krezel (Research Director at INSERM)
IGBMC, 1, rue L.Fries, 67404 Illkirch (CU Strasbourg), France
email: krezel@igbmc.fr