18.6.2018 | Ajankohtaista
The Fagerholm group at the Faculty of Bio- and Environmental Sciences, University of Helsinki is seeking to recruit a POSTDOCTORAL RESEARCHER
The position is available from 1st September 2018 for minimum of one year with the possibility of extension.
The postdoc will participate in an Academy of Finland-funded project which investigates the molecular mechanisms by which integrins regulate immune cell programming and immune cell-mediated tumor rejection.
The Fagerholm group consists of Immunologists and Biochemists working together to understand the molecular mechanisms which regulate immune cell trafficking and function in vivo. We are especially interested in the role of integrins in immune system regulation and in immune-system related diseases such as immunodeficiency and cancer. We use a wide range of techniques such as mouse genetics, tumor models, in vivo immune cell migration and other functional assays, flow cytometry, cell biology, imaging and next generation sequencing to understand the molecular mechanisms involved in the regulation of immune cell function.
Deadline for applications is 31.07.2018 23:59 EEST.
16.6.2018 | Ajankohtaista
Laboratory technician – Nightingale Health Oy, Helsinki
Are you passionate about healthcare and public health research? Do you want to work in a state of the art laboratory with cutting edge analytical technology?
Nightingale Health is looking for a laboratory technician to join our delivery team. Our delivery team serves global customers, using NMR spectroscopy to deliver analytical measurements for population health research and clinical use.
We’re looking for an enthusiastic and dependable laboratory technician with some prior knowledge of analytical measurements and work experience in a clinical laboratory. Previous experience of NMR spectroscopy or automated liquid handlers is not required but is considered an asset.
We are looking for people with:
– Trained laboratory technician or medical laboratory scientist (or equivalent) passionate about utilizing the latest measurement techniques, especially nuclear magnetic resonance (NMR) spectroscopy
– A ”quality first” mind-set
– Work experience with analytical measurements
– Willingness to adapt to a flexible team culture and learn novel measurement technologies
– Strong knowledge of the English language, Finnish is a plus but not mandatory
We offer:
– Responsibility and independence as a member of the delivery team
– Unique opportunity to work in a multidisciplinary team of scientists, developers and biotech business professionals
– Full-time position in our laboratory in Helsinki or Kuopio
– Attractive employment conditions and competitive salary
The position is available immediately or upon agreement.
How to apply?
If you are interested in joining our rapidly growing team, please send your application to people@nightingalehealth.com. The applications should include a cover letter and CV. The applications may be submitted in Finnish or in English.
16.6.2018 | Ajankohtaista
Sales Representative – SOPHiA GENETICS, Finlande
Job description
Ranked among the ”50 Smartest Companies” in the world according to the MIT Technology Review SOPHiA GENETICS is a fast-paced rapidly growing health tech company with a team of world renowned experts in the fields of technology (AI), life sciences (genomics) and information technology (data security) sectors.
SOPHiA GENETICS has developed SOPHiA™ Artificial Intelligence, the most advanced and used technology for clinical genomics. Deployed as a Software as a Service SOPHiA DDM® has connected over 425 world-leading hospitals and analyses thousands of patients’ genomics profiles each month to better and faster diagnose them.
In our mission to democratize Data-Driven Medicine, we are looking for bright, passionate and dedicated individuals to join our growing dynamic team. Does this sound like you? If so, we want to hear from you…
Sales & Business Development Manager
As part of the sales team, you will be in charge to acquire new accounts as well as managing existing ones within your territory (Finland, Estonia, Latvia, Lithuania) for our portfolio. This position requires to intensely travel across your territory as well as in Switzerland twice per year where is based our headquarter.
You will have to be creative and find solutions in order to meet clients. You will be supported by a well-resourced team of technical specialists and will leverage on our network within the clinical diagnostic testing field. The ability to develop long-term relationships with clients and communicate your enthusiasm for the potential of use of our solution transition to data-driven personalized medicine is essential. Our teams will support you in achieving ambitious goals in terms of acquisition of new clients and sales by sharing with you best practices. If you are client oriented and a result person you might probably join our team.
Qualifications and Experience
- A master degree in Sciences within a well-regarded institution; PhD will be an advantage.
- Excellent communication skills, including experience in communicating complex scientific principles in simple terms.
- Finnish and English (the business language) is mandatory.
- Ideally, previous experience as working as part of a team to develop the company’s customer base and provide a first-class experience to clients, preferably in the clinical diagnostics, biotechnology or medical technology market.
Starting date: ASAP
Location: Home office
If you think you fit this position, please send a CV and a cover letter.
Please note that incomplete applications will not be considered.
16.6.2018 | Ajankohtaista
Clinical Research Associate / Study Manager – PerkinElmer, Inc. Turku, VARS
Job description
PerkinElmer is currently looking for
Clinical Research Associate / Study Manager
Turku, Finland / Diagnostics
The Turku Site, with 550 employees, represents one of PerkinElmer’s major manufacturing and product development sites for newborn- and maternal fetal health screening. As the global market leader in newborn screening, our solutions have tested over 560 million babies worldwide for life-threatening diseases.
Medical and Scientific Affairs organization is responsible for clinical validation of our products. We now are looking for a new colleague to our global MSA team. The position may also be located in Sollentuna where PerkinElmer has a center of excellence for research and development of molecular diagnostic products.
Role description:
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- Plan, execute and report studies according to applicable regulatory requirements and company SOPs
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- Prepare study protocols and start-up activities at study sites
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- Obtain ethical and regulatory approvals
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- Monitor studies and report results
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- Coordinate studies and develop internal clinical study management procedures
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- Work in close collaboration with different functions and stakeholders including R&D, Regulatory and Business
Role requirements:
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- M.Sc or equivalent in bioscience
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- Experience in clinical studies, preferably related to In Vitro Diagnostic or Medical Device products
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- Excellent organizational and communication skills
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- Ability to work independently
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- Proven ability to work in global team environment
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- Fluent Finnish or Swedish and English (spoken and written)
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- Ability to travel up to 30 days per year, mainly in Europe
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- Depending on your previous experience with IVD clinical studies the position may be either Clinical Research Associate or Clinical Study Manager.
What we offer:
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- Opportunity to work in a global team
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- Dynamic and innovative culture
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- Focus on career development
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- Collaborative and diverse environment
In this position, you will be reporting to the Leader of Global Clinical Affairs, Turku. The position is temporary, approximately for 1 year, and can be located in Turku, Finland or Sollentuna, Sweden.
This position provides an exciting opportunity to work in a highly international business environment. If you are interested in the position and feel that you have the necessary skills and experience, please fill your application by June 25th, 2018. We will review the applications on an ongoing basis.
The PerkinElmer Turku Site is a drug free site and a medical examination for new employees includes a drug test.
16.6.2018 | Ajankohtaista
Solubiologi 1/2018 lehden pääkirjoitus sekä artikkeleiden abstraktit löytyvät nyt nettisivuiltamme! Muistathan, että yhdistyksen jäsenillämme on mahdollisuus lukea uusin Solubiologi-lehti myös jäsenintrassamme pdf-muodossa. Intrasta löytyy lehden lisäksi myös muunmuassa lista yhdyshenkilöistämme, joihin jäsenemme voivat olla yhteydessä esimerkiksi gradu- tai harjoittelupaikan tiimoilta. Tarkista tunnuksesi jäsenintraan viimeisimmästä jäsenkirjeestä!
16.6.2018 | Ajankohtaista
Pääkirjoitus, 28.05.2018
Suomen kesä on alkanut erittäin lämpimästi ja kesän tuloon liittyy tietysti myös vuoden ensimmäinen Solubiologi. Tämän vuotisen kevään numeron aloittaa Marjaana Parikainen, joka avartaa meille kollageeni I:stä sitovan α2β1-integriinin roolia eturauhassyövässä, ja tämän vaikutusta geeniekspressioon ja invaasioon. Seuraavaksi Teemu Syrjälä kertoo meille brominoituneista palonestoaineista ja niiden vaikutuksista syöttösoluihin. Tämänkertaisen tietopaketin päättää Moona Huttusen ulkomaankirjeenvaihtotervehdys, jossa käydään läpi hänen jo kolme vuotta kestäneitä seikkailuitaan Lontoossa University Collegessa, Englannissa.
Tänä kesänä saimme mahdollisuuden lähteä laboratorioryhmän kanssa joukolla Suomea pakoon vierailulle TuE:hen (Technische Universiteit Eindhoven) Eindhoveniin, Hollantiin, jossa tapasimme ryhmänjohtajamme Cecilia Sahlgrenin toisen ryhmän tiimiläisiä. Ahkerana professorina Cecilia pyörittää siis kahta kokonaisuutta, ja olihan se mielenkiintoista päästä tutustumaan teknillisen yliopiston työtapoihin ja tekniikkoihin. Tämä alunperin 1956 perustettu yliopisto kouluttaa pääasiassa insinöörejä teknologian alalla, mutta solu- ja kudostekniikan ja mikrofabrikoinnin laboratoriot yhdistävät solubiologiaa ja biotekniikkaa. Yhteistyö insinöörien ja solubiologien välillä on tärkeässä asemassa TuE:ssa, kun kehitetään esimerkiksi keinotekoisia sydänläppiä tai mikrosiruja, joilla halutaan simuloida erilaisia olosuhteita, joihin solut voivat joutua. Lopullisena päämääränä on kehittää niin sanottuja organ-on-a-chip –menetelmiä, joilla voitaisiin simuloida kokonaisia elimiä pienoismallissa.
Tämä jäänee omalta osaltani päätoimittajuuteni viimeiseksi Solubiologi-lehdeksi, koska syksyllä puikkoihin tarttuu J.J. Hyvää kesän jatkoa kaikille toivottaa SEb ja koko Solubiologin väki.
– Sebastian Landor
”I am the easy-going doctor who does not need to salute properly. You will find that I am always removing my gloves. The reason for my lab coat being a slightly different color to yours is never explained.”
1. Artikkeli. Kollageenireseptori α2-integriini säätelee eturauhassyöpäsolujen geeniekspressiota ja invaasiota, Marjaana Parikainen (FM)
Erikoistyössä tutkittiin α2-integriinin vaikutusta eturauhassyöpäsolujen geeniekspressioon sekä solujen migraatioon ja invaasioon neljällä α2-integriiniä erilaisesti ilmentävällä DU145-solutyypillä. α2-integriinin havaittiin säätelevän tiettyjen geenien ilmentymistä sekä RNA- että proteiinitasolla mutta se ei vaikuttanut säätelemiensä proteiinien lokalisaatioon solussa. Lisäksi havaittiin, että α2β1-kollageeni I -vuorovaikutus lisäsi solutyyppien välisiä RNA-tason ilmentymiseroja suurimmalla osalla tutkituista 12 geenistä, minkä perusteella α2-integriinin aktivoituminen ja signalointi ligandivuorovaikutuksessa säätelee näiden geenien ilmentymistä. α2-integriiniä ilmentävät solut invasoivat enemmän Matrigeeliin ja kollageeni I:een kuin α2-integriiniä ilmentämättömät solut. Tulosten perusteella α2β1-integriiniin kohdentuvaa syöpähoitoa voitaisiin mahdollisesti hyödyntää eturauhassyövän luumetastaasien estämiseen.
2. Artikkeli. The effects of some common brominated flame retardants (bfrs) on cell degranulation and cell viability in a mast cell line, Teemu Syrjälä (Biomedical Laboratory Scientist, Bachelor of Health Care; EQF6)
The aim of this study was to investigate the effects of two commonly used brominated flame retardants, tetrabromobisphenol A (TBBPA) and hexabromocyclododecane (HBCD), on degranulation and viability of a mast cell line RBL-2H3. Assays measuring and monitoring cell viability and the release of inflammatory proteins via degranulation were developed. The results showed that both TBBPA and HBCD cause substantial cell death over a long-term exposure in vitro. Both compounds caused some degranulation of the cells, although the results from HBCD turned out to be quite modest compared to those gotten from TBBPA. TBBPA greatly induced cell death by apoptosis while only a very small degree of necrotic cell death was observed. While the degree of necrosis caused by HBCD remains unknown, it was shown to also induce apoptotic cell death at least to some extent. The study concludes that TBBPA, based on the results, does seem to be a mast cell sensitizing agent. HBCD has great potential to have similar effects, although this requires further research.
3. Artikkeli. Ulkomaankirjeenvaihtaja, London University College (UCL) Englanti, Moona Huttunen (FT)
15.6.2018 | Ajankohtaista
We are recruiting a Ph.D student to join our young and dynamic research team of translational research at the Department of Oral and Maxillofacial diseases, University of Helsinki (https://www.helsinki.fi/en/researchgroups/translational-research-on-oral-and-maxillofacial-sciences/research).
The position is available from 1st September 2018 for one year with the possibility of extension. You will be the part of the multifaceted projects aimed at understanding the role of extracellular vesicles in osteosarcoma development and progression; developing 3D models for osteosarcoma; bone tissue engineering/applications of biomaterials and stem cells. In addition to strong written and oral communication skills, experience with techniques in genetics, cell biology, cell imaging, RNA sequencing, biochemistry and bioengineering are considered favorable.
14.6.2018 | Ajankohtaista
The Institute for Molecular Medicine (FIMM) and Bayer are seeking a joint postdoctoral researcher who has interest in anticancer drug development, and experience in cell and molecular or computational biology, or other related areas. The successful candidate will gain a rich and varied insight into drug development processes through exposure to both biomedical research at FIMM and clinical trials management at Bayer.
The application deadline is 25.6.2018 at 23.59 EET. Applications are submitted by completing the application form and submitting a CV and a cover letter as a single PDF file (max 5 pages) in English through the University of Helsinki electronic recruitment system https://www.helsinki.fi/en/open-positions/fimm-bayer-joint-postdoctoral-researcher. Internal applicants (i.e., current employees of the University of Helsinki) must submit their applications through the SAP HR portal.
13.6.2018 | Ajankohtaista
The discovery of a fatal neurodegenerative disease in childhood with fibrosis, and cerebral angiomatosis (FINCA disease) has highlighted the importance of NHLRC2 in the central nervous system (Uusimaa et al. 2018) (doi: 10.1007/s00401-018-1817-z). We are now looking for a postdoctoral scientist to focus on characterizing the role of NHLRC2 during neurogenesis in a two-year project funded by the Academy of Finland.
Applications, together with all relevant attachments, must be submitted using the electronic application form by 31.7.2018.
13.6.2018 | Ajankohtaista
We are now recruiting a top caliber Medical Scientific Liaison / Scientific Advisor to join the Bayer Finland Medical Affairs team. As a Medical Scientific Liaison you will serve as the primary scientific resource for the medical community by responding to their information needs on Bayer products and therapies. You will facilitate internal and external scientific collaborations with Physicians and other Health Care Professionals and support them with accurate and updated medical information, as well as identify, initiate and implement medical based projects. You will organize and support scientific events including peer to peer communication, scientific exchange meetings and advisory boards. You will act as a strategic partner for the cardiology brand team to share feedback from the market internally, while being fully updated and maintain the highest level of clinical and scientific knowledge within the therapy areas.
YOUR TASKS AND RESPONSIBILITIES
- act as a scientific expert between Bayer and the medical community through the dissemination and education of scientific data and material
- plan, prepare and engage with Health Care Professionals as an information scientist both proactively and reactively via various engagement tactics and formats
- provide dissemination, clarification and education of scientific data and professional literature
- establish long-term scientific/strategic relationships with key individuals, major medical associations and academic centers of excellence
- interact with key external medical and pharmacy professionals via one-on-one interaction, small group discussion, symposia lecture presentations and interactions associated with medical education programs
- answer medical / scientific queries of internal and external stakeholders
- attend congresses and conventions, interact with Health Care Professionals, establish new contacts and gather competitive intelligence
- plan and organize scientific training and education events with Health Care Professionals within their specific therapeutic area or product
- submit timely reports and track activities against agreed objectives
- The role is field-based, which means 70-75% travelling time
THE IDEAL CANDIDATE
We expect you to have a medical or scientific background with established relations to the medical community, and preferably a Ph.D. or other strong background in the relevant therapeutic area. You have experience from the industry in a relevant role and knowledge of the clinical development process. You are capable of comprehending large amounts of scientific content which you can communicate in a clear and concise way and have excellent presentation skills. As a person you are a team player, self-driven, independent, resourceful and trustworthy. You have strong statistical skills with ability to extract insights from data. We expect you to enjoy creating new contacts and have good social skills. You are also excellent at communicating, both verbally and in writing. You are fluent in Finnish as well as English orally and written.
Please submit your application with your CV and salary request by June 24 at the latest. Candidates will be reviewed on a continuous basis.
