21.12.2016 | Ajankohtaista
Haemme kahta väitöskirjatutkijaa Immuno-oftalmologian tutkimusryhmään (http://www.uef.fi/eye/io) Itä- Suomen yliopiston Kuopion kampukselle. Tutkimusryhmä on osa yliopiston strategian mukaisia nousevia tutkimusaloja. Silmänpohjan ikärappeuman mekanismit ja uusien terapiakohteiden etsintä tarjoavat mielenkiintoisen tutkimusalueen, missä biolääketieteellistä perustutkimusta tekevät tutkijat työskentelevät yhteistyössä kliinikoiden ja lääkekehityksestä vastaavien tahojen kanssa. Työhön kuuluu solun toimintojen mittaamista ja solunsisäisen signaloinnin määritystä.
Hakijan tulee olla jatkokoulutuskelpoinen, ylemmän yliopistotutkinnon solu- tai molekyylibiologiasta, biokemiasta, farmasiasta tai vastaavalta alalta korkeintaan neljä vuotta sitten suorittanut, motivoitunut, sitoutunut sekä organisointi- ja ongelmanratkaisukykyinen. Hakijan hyväksi luetaan aiempi laboratoriotyöskentely erityisesti kokemus soluviljelystä sekä proteiinikemian ja immunologian määritysmenetelmistä.
Hakemukset tulee lähettää yhtenä PDF-dokumenttina osoitteeseen anu.kauppinen@uef.fi 31.1.2017 mennessä. Paikat täytetään alkuun yhdeksi vuodeksi. Hakemukseen tulee liittää 1) motivaatiokirje 2) CV 3) julkaisuluettelo 4) kaksi suosituskirjettä (vapaaehtoinen) Yhteydentotot: Apulaisprof., akatemiatutkija Anu Kauppinen, anu.kauppinen@uef.fi
16.12.2016 | Ajankohtaista
Description
Research in the Engin Lab, at University of Wisconsin-Madison, School of Medicine Department of Biomolecular Chemistry, is at the interface of endoplasmic reticulum stress, autoimmunity and immunology. We thrive to understand how stressed pancreatic beta cells and immune cells communicate during the progression of autoimmune diabetes, and how immunometabolic pathways and organelle homeostasis contribute to the autoimmunity. The highly interdisciplinary and collaborative environment of our group provides unique career development opportunities for the postdoc trainees. Please refer to our representative publications for details: Engin et al., Sci. Transl. Med. 2013, Engin et al., Sci. Rep. 2014.
Qualifications
• Recent Ph.D. with a strong background in the field of immunology and/or cell biology.
• Research experience in areas useful to studies of cell signaling, adaptive immunity, T cell biology, inflammation, and autoimmunity.
• Basic understanding of and experience with molecular biology and immunology related assays.
• Ability to work with mice.
• Ability to learn and develop new techniques, whenever necessary.
• Strong evidence of scientific accomplishment.
Job Duties
The candidate can either lead promising ongoing projects, or initiate and develop independent research projects within the broad realm of stress, immunology and diabetes. Candidate will receive active feedback and guidance in experimental planning, data presentation, manuscript writing, and development of grant proposals, as applicable. Additional responsibilities include: maintaining laboratory records, supervising students, and training laboratory staff in techniques and protocols.
Application
Candidates with outstanding oral and written communication skills, and strong relevant experience are encouraged to apply. Please send a cover letter with a short description of potential areas and projects, current CV, and three references to Dr. Feyza Engin (fengin@wisc.edu). A competitive stipend and excellent benefits will be provided for this position.
For more information, please visit our website: https://bmolchem.wisc.edu/engin.htm
https://www.researchgate.net/job/881092_Postdoc-Bioinformatics_Systems_Cardiology
16.12.2016 | Ajankohtaista
We are looking for a second postdoctoral researcher to join our team. The projects involve – apart from enthusiasm and dedication – the setup of novel methods and requires knowledge and experience in the areas of molecular biology (cloning, mutagenesis), E. coli genetics, protein analysis (Western, IP, ELISA), protein purification (basics) and cell culture (transfection, cell line establishment). Knowledge in bioinformatics will be advantageous. Project goals include improvements of in-vitro antibody generation technologies and the generation of antibodies. Details will be discussed in the job interview.
The postdoctoral position is for two years and will start during spring 2017 with a probation period. The salary is based on the standard University of Helsinki salary system. Applications are considered as soon as they arrive and there is no fixed closing date since before we can hire, we have to relocate our lab in-house to have more lab space, which will happen sometime during beginning of 2017.
How to apply?
If you are interested, please send your application including CV, motivation letter and names of two people who would be willing to provide references with contact information as a single pdf-document to michael@jeltsch.org with a notification ”MSc position”/”PhD position”/”Postdoc position” in the subject line of the mail. Please also attach or link to a short (maximally 2 minutes long) video, in which you explain, why you want to join our lab and why you are the candidate that we should chose. Please follow these instructions as I do not guarantee to answer applications that don’t fulfill these formal requirements.
For further information, see http://lab.jeltsch.org or contact Michael Jeltsch by e-mail (michael@jeltsch.org).
16.12.2016 | Ajankohtaista
A postdoctoral position is available in Dr. Z. Jim Wang’s laboratory at the University of Illinois medical campus in Chicago. A Ph.D. in a biomedical field is required. Experience with pain or opioid research is preferred, but not required. Our research focus is on molecular mechanism, epigenetics, and pharmacology of chronic pain and opioid pharmacology (see recent publications below).
To apply, please email curriculum vitae to:
Z. Jim Wang, PhD (zjwang@uic.edu)
Professor of Pharmacology
Department of Biopharmaceutical Sciences
Cancer Center, Sickle Cell Center, &
Program for Collaborative Research in the Pharmaceutical Sciences
University of Illinois, Chicago, IL 60607
(312) 355-1429
Some of our recent publications:
1.He Y, Wilkie DJ, Nazari J, Wang R, Messing RO, DeSimone J Molokie RJ, and Wang ZJ, PKCd-targeted intervention relieves chronic pain in a murine sickle cell disease model, J Clinical Investigation 2016, 126, 3053-7. PMID: 27348590.
2. He Y, Chen Y, Tian, X, Yang, C, Lu J, Xiao C, Desimone J, Wilkie DE, Molokie R, Wang ZJ, CaMKIIα underlies the spontaneous and evoked pain behaviors in Berkeley sickle cell transgenic mice. Pain 2016, 157: 2798–2806. PMID: 27842048
3. Hu X, Huang F, Szymusiak M, Liu Y and Wang ZJ, PLGA-curcumin attenuates opioid-induced hyperalgesia and inhibits spinal inhibition of CaMKIIα, PoLS One, 2016; 11(1):e0146393. doi: 10.1371. PMID: 26744842
4. He Y, Wang ZJ, Nociceptor bII, d & e isoforms of PKC differentially mediate paclitaxel-induced spontaneous and evoked pain. J Neurosci 2015; 35(11):4614-25. PMID:25788678
5. Jhun E, He Y, Yao Y, Molokie RE, Wilkie DJ, Wang ZJ, Dopamine D3 receptor Ser9Gly and catechol-O-methyltransferase Val158Met polymorphisms and acute pain in sickle cell disease. Anesthesia & Analgesia 2014, 119(5):1201-7. PMID: 25102390
6. He Y, Yang C, Kirkmire CM, and Wang ZJ, Regulation of opioid tolerance by let-7 family microRNA targeting the μ opioid receptor. J Neurosci 2010;30(30):10251-8. PMID: 20668208.
2.12.2016 | Ajankohtaista
Position for a highly motivated and enthusiastic PhD student is available in virology / cell biology / biochemistry at the laboratory of Docent Tero Ahola, University of Helsinki, starting from January or February 2017 (or later by agreement). The group is part of the Department of Food and Environmental Sciences, Division of Microbiology and Biotechnology. The work is carried out under the supervision of Docent Maija Pietilä and Tero Ahola.
The student would take part in a research project studying formation, structure and function of viral replication complexes. This Academy of Finland- and University of Helsinki-funded project focuses on the replication of positive-strand RNA viruses. Such viruses have a major role in emerging and re-emerging epidemics, and new antiviral strategies are a necessity. All such viruses replicate their genome in membrane-associated complexes, and our aim is to understand how these complexes are formed and which cellular and viral factors are essential for their function in RNA synthesis. This information would help us to fight against infections caused by positive-strand RNA viruses.
The laboratory has long experience in studying the replication mechanisms of animal RNA viruses, using biochemical, virological and cell biological methods, including advanced fluorescence and electron microscopy. More information concerning the group is available at:
https://tuhat.halvi.helsinki.fi/portal/en/person/tahola
https://tuhat.halvi.helsinki.fi/portal/en/person/mpietila
For a successful applicant, previous experience with virus work is not necessary, but good knowledge and skills in biochemistry and cell biology are required. Especially, experience with RNA work and proteomics would be beneficial. We are seeking for motivated candidates able to work both independently and as a member of a team, with a strong interest in molecular biosciences, and willing to take initiative as well as capable of developing skills towards independent and creative scientific work. Fluent English communication skills (oral and written) are required.
The application should contain a cover letter stating applicant’s research interests and career motivation and curriculum vitae detailing the education and experience of the candidate, and the contact information of two references. Please compile all materials to a single PDF file. For more information on the advertised position, please contact Docent Maija Pietilä and send applications by email (maija.pietila@helsinki.fi). Interested students are encouraged to send their application latest by December 30th 2016.
Please contact:
Maija Pietilä, PhD, Docent in Virology
Academy of Finland Postdoctoral Research Fellow
Division of Microbiology and Biotechnology
Department of Food and Environmental Sciences
University of Helsinki
Viikinkaari 9, P.O. Box 56
00014 University of Helsinki
email: maija.pietila@helsinki.fi
phone: +358-504486393
2.12.2016 | Ajankohtaista
Are you looking for excellent research opportunities for your PhD studies at the forefront of basic, epidemiological or translational cancer research? At the German Cancer Research Center (DKFZ) in Heidelberg, Germany’s largest biomedical research institute, more than 500 PhD students unravel the causes of cancer development and develop novel tools for diagnosis, treatment and prevention.
PhD students are supported by a Thesis Advisory Committee, participate in scientific and professional skills courses, attend international conferences and receive career development support. The language of the PhD program is English. Full funding is provided for the duration of the PhD, either by the DKFZ, third party sources or in collaboration with the DAAD within their Graduate School Scholarship Program.
The DKFZ offers PhD projects in diverse and interdisciplinary cancer research topics:
• Cell Biology and Tumor Biology
• Functional and Structural Genomics
• Cancer Risk Factors and Prevention
• Tumor Immunology
• Imaging and Radiooncology
• Infection, Inflammation and Cancer
• Translational Cancer Research
Applications are invited from international students holding the equivalent of a university Master’s degree in the natural sciences. Research experience and
excellent English skills are a prerequisite.
Application deadline 5th January 2017.
2.12.2016 | Ajankohtaista
A postdoctoral opportunity is immediately available within the Group to apply state-of-the-art molecular/cell biology and new functional genomic tools for mechanistic studies focusing on functionally important epigenetic “driver” genes (“epidrivers”) and associated molecular pathways. This also includes the development and application of in- vitro models (for example, human and mouse immortalization models), new (epi)genome editing tools, and functional genomics. We also study interactions of epidrivers with selected known and suspected carcinogens (with focus on non-genotoxic “epigenetic” agents) that may play a role in tumour initiation and progression through epigenetic mechanisms.
Candidates with a solid background in epigenetics, molecular biology, and cancer research with a good command of English are encouraged to apply. Experience in genome editing (such as CRISPR-Cas9 system), genome-wide shRNA screens and functional (epi)genomics would be an asset.
The postdoctoral opportunity is initially for one year with possibility of extension. The IARC stipend is currently €2750 per month (net of tax). The cost of travel for the post-doc, and in certain circumstances for dependants, will be met, a dependant’s allowance paid, and health insurance covered.
Applicants should send a CV, including list of publications and a description of previous research experience, as well as the names and addresses of two academic referees, preferably by email to: Email: ege@iarc.fr
To the attention of:
Dr Z. Herceg, Epigenetics Group
International Agency for Research on Cancer
150, cours Albert Thomas
69372 Lyon Cedex 08, France
Tel +33-472738398
9.11.2016 | Ajankohtaista
Ilmoittaudu Korpissa (https://korppi.jyu.fi/kotka/r.jsp?course=208550) tai laittamalla sähköpostia osoitteeseen suomensolubiologit@gmail.com, vielä mahtuu mukaan!
7.11.2016 | Ajankohtaista
A PhD student position in ovarian cancer research at University of Turku
A doctoral student position is open in the ovarian cancer research group at the Department of Pathology and Forensic Medicine, Institute of Biomedicine, University of Turku, Finland. The research group focuses on translational cancer research on high-grade serous ovarian cancer.
We are looking for an enthusiastic, highly motivated person to study treatment resistance mechanisms, markers for resistance prediction and drugable targets for personalized ovarian cancer treatment. Survival of the ovarian cancer patients is very poor due to typical late diagnosis and development of treatment resistance. We have recently identified a set of expression markers that predicts ovarian cancer patient survival (Chen, Huhtinen, et al 2015 Cancer Res) and identified potential mechanisms leading to platinum resistance, which works as a background for the PhD project.
This project focuses on evaluating the role of the prognostic markers in drug resistance and development of new tools for diagnosis and treatment of the patients. The work is a part of ongoing multidisciplinary research collaboration between clinical, systems biology and laboratory researchers and is connected to EU H2020 Hercules project. We use diverse and modern laboratory methods, including cell free DNA analysis, CrispR-Cas gene knockdown, Chip-Seq and next generation sequencing, as well as both clinical samples and patient derived primary cell lines. The project will be performed in the laboratory of Professor Olli Carpén at the Department of Pathology and Forensic Medicine, Institute of Biomedicine, University of Turku, Turku, Finland, under supervision of docent Kaisa Huhtinen. The position will start as soon as possiblewith 3 months trial period.
Candidate requirements:
– MSc in biosciences e.g. molecular biology, biochemistry or health biosciences (already obtained or soon-to-be) or medical student at biomedical research track
– Highly motivated person with strong interest in translational cancer research
– Ability to strive for the progress of the project
– Good skills in both oral and written English and in team-working
To apply, please send the following documents as a SINGLE PDF DOCUMENT to kaisa.huhtinen(at)utu.fi: motivation letter (incl. statement of research interest and skills relevant for the position), CV, list of publications, and recommendation letters or contact information of the references. The deadline for the application is 30th of November 2016. Only individuals invited to an interview will be contacted.
Contact information:
Kaisa Huhtinen
PhD, Docent in Cancer Biology
Department of Pathology and Forensic Medicine
Institute of Biomedicine
Tykistökatu 6B (Biocity)
20014 University of Turku
Mobile: +358 405828506
E-mail: kaisa.huhtinen[at]utu.fi
7.11.2016 | Ajankohtaista
UNIVERSITY OF OXFORD
DEPARTMENT OF BIOCHEMISTRY
Two Postdoctoral positions – Towards deciphering mechanisms of transcriptional and post-transcriptional gene regulation in eukaryotic cells
Two postdoctoral positions are available early 2017 in the laboratory of Lidia Vasiljeva funded by a Senior Research Fellowship from the Wellcome Trust at the Department of Biochemistry, University of Oxford (http://www.bioch.ox.ac.uk/ ), which is a part of the University of Oxford’s thriving scientific community. The laboratory is located in a new state-of-the-art building providing interactive environment and various research facilities.
We are looking for highly motivated candidates with an interest in gene regulation in yeast and mammalian cells. The proposed projects will utilize state-of-the-art biochemistry and structural approaches combined with the functional genome-wide analysis to understand how transcription factors and chromatin modifiers regulate transcription of protein-coding and non-coding genesis in yeast and mammalian cells. The structural study will be done as a part of existing productive collaboration with Jonathan Grimes laboratory at STRUBi (Oxford). Candidates trained in protein purification, RNA analysis, and mammalian cell culture are encouraged to apply. Basic knowledge of bioinformatics is beneficial. Applicants should have or will shortly obtain a PhD and are expected to be highly motivated, with excellent critical thinking skills and with good communication skills and have the ability to work as part of a team.
Interested applicant should contact Dr Lidia Vasiljeva directly:
