Asiantuntija (Kudospankki)

24.8.2024 | Avoimet työpaikat

https://www.jobly.fi/tyopaikka/asiantuntija-kudospankki-2163860?source=job_alert&utm_source=job_alert&utm_medium=email&utm_campaign=job_alert&utm_content=job_title

Tampereen yliopisto ja Tampereen ammattikorkeakoulu muodostavat yhdessä Suomen toiseksi suurimman monitieteisen, innostavan ja vaikuttavan tutkimus- ja oppimisyhteisön. Korkeakouluyhteisömme osaamiskärjet ovat tekniikka, terveys ja yhteiskunta. Lue lisää: [www.tuni.fi](https://www.tuni.fi/)

Haemme nyt kliinisen kudospankin tehtäviin asiantuntijaa. Tehtävä sijoittuu [Lääketieteen ja terveysteknologian tiedekunnassamme](https://www.tuni.fi/fi/tutustu-meihin/laaketieteen-ja-terveysteknologian…) toimivaan Regea kudospankkiin. Tehtävä on kokoaikainen ja se täytetään toistaiseksi voimassa olevana 1.11.2024 lukien tai sopimuksen mukaan.

[Regea kudospankki](https://www.tuni.fi/fi/tutustu-meihin/regea-kudospankki) ottaa talteen, käsittelee ja välittää kudoksia kliiniseen käyttöön. Toiminnassa noudatetaan laatujärjestelmää, jonka vaatimukset perustuvat kudoslakiin. Toimintaa valvoo Lääkealan turvallisuus- ja kehittämiskeskus Fimea.

Tehtäväkuvaus

Haemme asiantuntijaa Regea kudospankin tehtäviin. Tehtävänkuva käsittää esimerkiksi kudossiirteiden käsittelyä ja arviointia, puhdastilaympäristön mikrobiologista olosuhdevalvontaa, laadunhallintajärjestelmien kehittämistä ja ylläpitoa sekä laboratoriolaitteiden kvalifiointeihin liittyviä tehtäviä. Tehtävään kuuluu käytännön laboratoriotyötä, josta osa tehdään puhdastilassa. Tehtävään saa kattavan perehdytyksen.

Edellytykset

Tehtävään edellytetään soveltuvaa ylempää korkeakoulututkintoa, kuten luonnontieteiden FM tai vastaava. Tehtävän hoito edellyttää sujuvaa suomen ja englannin kielen taitoa. Eduksi katsomme kokemuksen laadunhallintajärjestelmistä sekä solu- tai kudosviljelystä. Tehtävän hoidossa korostuvat hyvät yhteistyötaidot, järjestelmällisyys ja itsenäinen työote.

Tampereen yliopisto on ainutlaatuinen, monialainen ja rohkeasti tulevaisuuteen katsova, kehittyvä yhteisö. Meille tärkeitä arvoja ovat avoimuus, kriittisyys, moninaisuus, oppijalähtöisyys, rohkeus, sivistys ja vastuullisuus. Toivommekin, että voit osaltasi sitoutua näihin arvoihin ja edistät niiden mukaista toimintaa omassa tehtävässäsi.

Tarjoamme

Kokoaikainen asiantuntijan tehtävä täytetään toistaiseksi voimassa olevana 1.11.2024 alkaen tai sopimuksen mukaan. Tehtävässä sovelletaan työsopimuslain mukaista koeaikaa.

Tehtävän palkkaus määräytyy yliopistojen yleisen työehtosopimuksen [muun henkilöstön palkkausjärjestelmän](https://www.sivista.fi/tyosuhdeasiat/tyoehtosopimukset-ja-palkkataulukot…)mukaisesti. Asiantuntijan tehtävässä alustava vaativuustaso on 9, minkä lisäksi maksetaan henkilökohtaiseen työstä suoriutumiseen perustuvaa palkanosaa. Aloittavan asiantuntijan tehtävän palkka on noin 3900–4100 euroa riippuen valittavan henkilön kokemuksesta.

Tarjoamme sinulle vastuullisen ja monipuolisen työtehtävän. Työssä sinua tukee esihenkilön lisäksi asiantuntevat ja ammattitaitoiset kollegat. Autamme sinua perehtymään työtehtäviisi ja pääsemään sujuvasti sisään työyhteisöömme.

Henkilöstöetuihimme kuuluvat mm. joustavat työskentelymahdollisuudet, liikunta- ja kulttuurietu, kattavat työterveyshuollon palvelut sekä ”tunti työajasta liikuntaan” etu. Työskentelemme joustavasti etänä ja Tampereen kaikilla kolmella kampuksella, joissa käytettävissäsi ovat edulliset ravintola- ja kahvilapalvelut.

Lue lisää työskentelystä meillä [työnantajasivuiltamme](http://www.tuni.fi/toihin). Tervetuloa innovatiiviseen työyhteisöömme luomaan merkityksellistä uraa sekä vaikuttamaan yliopistomme ja yhteisen kulttuurimme kehittymiseen.

Hakuohjeet

Jätäthän hakemuksesi sähköisellä lomakkeella (linkki löytyy tämän ilmoituksen alta). Hakuaika tehtävään päättyy 3.9.2024 klo 23:59.

Liitä hakemukseesi PDF-muodossa:

– Ansioluettelo
– Vapaamuotoinen motivaatiokirje (1-2 sivua)

Hakuajan päätyttyä kutsumme soveltuvimmat hakijat haastatteluihin. Haastatteluiden lisäksi käytämme mahdollisesti ulkopuolisen palveluntarjoajan toteuttamia soveltuvuusarviointeja.

Lisätietoja tehtävästä antaa Tiia Tallinen p. 050 568 0428, tiia.tallinen@tuni.fi.

Jätä hakemus:  https://tuni.rekrytointi.com/paikat/index.php?o=A_A&jid=2381&jbid=15
Työpaikan osoite:  33520
Työ alkaa:  01.11.2024
Työaika:  Kokoaikatyö
Työn kesto:  Toistaiseksi voimassa oleva
Hakuaika päättyy:  03.09.2024 20:59
Ilmoitus jätetty:  13.08.2024 12:30
Työmarkkinatorin ilmoitusnumero:  b166659b-a4bd-466e-99c4-408a163eb09f

Lähde: Työmarkkinatorin asiakastietojärjestelmä

Research Coordinator – FIMM

24.8.2024 | Avoimet työpaikat

https://jobs.helsinki.fi/job/Helsinki-Research-Coordinator/801146102/?feedId=360857

The Institute for Molecular Medicine Finland (FIMM) is an international research institute focusing on human genomics and personalised medicine at the University of Helsinki. In the beginning of 2017 FIMM joined the University of Helsinki’s new life science research centre, Helsinki Institute of Life Science HiLIFE, as an operational unit. FIMM integrates molecular medicine research, technology centre and biobanking infrastructures under one roof, promoting translational research in grand challenge projects, specifically, the impact of genome information from the Finnish population in personalised health and medicine, individualised cancer medicine, and digital molecular medicine. FIMM is part of the Nordic EMBL Partnership for Molecular Medicine, composed of the European Molecular Biology Laboratory (EMBL) and the centres for molecular medicine in Norway, Sweden and Denmark, and the EU-LIFE Community.

FIMM is currently seeking a

Research Coordinator

for a fixed term of two years with a possibility of extension.

We are seeking a qualified and motivated Research Coordinator for national and international research projects of Human Genomics Unit at FIMM led by Professors Samuli Ripatti and Aarno Palotie.

Samuli Ripatti, PhD, is the Director of the Institute for Molecular Medicine Finland (FIMM), HiLIFE, Professor of Biometry at the Faculty of Medicine, University of Helsinki and at Massachusetts General Hospital and Broad Institute of MIT and Harvard. He is chairing the Academy of Finland Centre of Excellence in Complex Disease Genetics and EU H2020-funded Intervene Consortium. His research group studies genetic variation in the Finnish population and its effects on common complex disease risks and management. He is one of the pioneers in developing and testing the clinical translation of polygenic risk scores in disease prevention and early detection.

Professor Aarno Palotie, M.D., Ph.D. is the Research Director of the Human Genomics program at the Institute for Molecular Medicine Finland (FIMM), HiLIFE. He is also a faculty member at the Center for Human Genome Research at the Massachusetts General Hospital in Boston and an associate member of the Broad Institute of MIT and Harvard.

Prof. Palotie is the Scientific Director of the large FinnGen project (www.finngen.fi) that combines the genome and national health record data from 500 000 Finnish participants. He has chaired several large international research consortia, like the Sequencing Initiative Suomi, SISu (www.sisuproject.fi) combining all Finnish sequences for a data resource and variant catalogue, the SUPER project (www.superfinland.fi) collecting and studying genetics in over 10 000 Finnish psychosis patients, the International Headache Genetics Consortium (IHGC, www.headachegenetics.org) and the Northern Finland Intellectual Disability (NFID) study.

The candidate is expected to assist Professors Ripatti and Palotie and collaborating senior scientists at FIMM Human Genomics Unit to coordinate and manage the international research projects involved, for example, EU FP7/H2020 projects, NIH projects, the Academy of Finland Center of Excellence and other collaboration projects. Major tasks include monitoring project progress, liaising with financial and administrative staff, organizing and participating in project meetings, preparing reports and communicating with funding agencies and collaborators.

The successful candidate should hold a PhD degree with minimum two-years working experience, preferably in the field of life science related discipline. Experience in project coordination and management at international level (especially large-scale consortium management experience) is appreciated. The candidate should have fluency in written and spoken English (knowledge of Finnish or other European language will be an advantage), excellent organizational, communication and problem-solving skills, strong capability to work independently as well as cooperate harmoniously with administrative staff. The candidate should be available to travel abroad (occasionally and mostly within Europe).

This is a full-time position based in Biomedicum 2, Helsinki (www.biomedicum.fi), Finland, and is expected to start on October 1st, 2024 or earlier for an initial period of at least two years with a possibility of extension. A trial period of 6 months will be applied.

Salary will be based on the University salary scheme for research and teaching staff. The starting salary will be ca. 4,200 – 4,600 euros/month, depending on the appointee’s qualifications and experience and including a salary component based on personal performance.

To apply for the position, please send your motivation letter and CV, including list of publications and contact information for two references, through the University of Helsinki electronic recruitment system by clicking on the Apply link. Internal applicants (i.e., current employees of the University of Helsinki) please submit your applications through SAP Fiori https://msap.sap.helsinki.fi .

Please apply no later than September 6th. The employment may begin as soon as possible or as agreed.

For further information please visit our website at http://www.fimm.fi and/or contact Professors aarno.palotie(at)helsinki.fi, samuli.ripatti(at)helsinki.fi or Project coordinator sari.kivikko(at)helsinki.fi. Technical support regarding the recruitment system: rekrytointi@helsinki.fi.

Research Scientist in Formulation Development Espoo – Fermion

24.8.2024 | Avoimet työpaikat

https://www.jobly.fi/tyopaikka/research-scientist-formulation-development-espoo-2164408

Description of position

We are looking for a research-driven and motivated formulation scientist with experience in advancing small molecule drug development projects. We operate within oncology and pain therapy areas.

Your main responsibility is to develop formulations for oral solid dosage forms. This includes for example planning and running studies exploring their feasibility and confirming their appropriateness for the intended use. You will review results, summarize and make conclusions of the studies, and document the work for registration purposes. The work includes regular hands-on laboratory work. As a key player in CMC team you will create forward-looking formulation strategies that enable the development of a high-quality drug product through the clinical phase into registration and launch. You also manage and organize development related tasks, thus the position involves intensive collaboration with internal and external stakeholders working closely together in multi-disciplinary teams.

This temporary (1 year) position is based in Espoo or Turku, Finland.

Description of unit

This position is situated in Clinical Product Development unit, which belongs to Pharmaceutical Sciences department within Orion Pharma Research and Development. Your peers are scientists working with formulation development, and chemical and physical analytics. We operate in project CMC teams to develop new drug products.

We offer

We offer a great team to join with skilled and highly motivated colleagues. Appreciation of colleagues and continuous development are part of our core values. We enable opportunities to utilize your skills and competencies widely as we continuously create something new.

Learn more about Orion as an employer on our website: https://www.orion.fi/en/careers/orion-as-an-employer/

Requirements

To succeed in this role, you possess the following:

Master’s or preferably doctoral degree in pharmaceutical sciences or a related field
Demonstrated skill in developing pharmaceutical oral solid dosage forms and manufacturing processes (granulation, tableting, etc.)
Experience in application of QbD concept in design, execution, and interpretation of formulation and process development experiments
Understanding of analytical characterization of formulations (chemical, physical and biopharmaceutical)
Experience of working in a GMP-regulated environment preferred
Ability to collaborate well in cross-functional teams internally and in external networks with academia, CROs and partners
Experience in authoring regulatory submissions
High degree of professionalism, ethics and integrity
Excellent presentation and written/verbal communication skills in English

Personal qualities we are looking for are:

Strong organizational skills and attention to detail
You are a doer and have an accurate working style
Forward thinking mindset with the ability to manage multiple projects, and identify and resolve issues.
Motivated to learn

Additional information

If you are interested in this opportunity, please apply by 1st of September 2024. We may process applications already during the application period, so please submit your application and CV as soon as possible.

If you have any questions, please contact Head of Clinical Product Development Satu Lakio Tel. +358 50 9664422 on Mon 19th of Aug at 14.00 – 15.00 or Fri 30th of Aug at 14.00 – 15.00 (EET).

#LI-ORION

Approved medical examination which also includes drug testing is required prior to the employment.

Orion Corporation operates in more than 30 countries, where we Orionees, 3600 in total, work in all kinds of positions. Among us there are Research Scientists, Laboratory Technicians, Engineers and IT Specialists as well as people working in Production, just to mention some examples. We offer diverse and responsible jobs to our personnel in a truly multi-disciplinary work environment. We encourage people to develop their competences and offer opportunities to affect the job description and creating their own career path at Orion. We are searching for top talents who are ready to share our passion for the work that we do.

Production Specialist, downstream processes – Hytest

24.8.2024 | Avoimet työpaikat

https://www.jobly.fi/tyopaikka/production-specialist-downstream-processes-2165122?source=job_alert&utm_source=job_alert&utm_medium=email&utm_campaign=job_alert&utm_content=job_title

We are happy to announce opening of a new vacancy in Production department – Production Specialist, downstream processes:

Requirements:

Education – degree in biochemistry/biotechnology/immunology or relevant field (M.Sc, B.Sc, B.Eng)
Knowledge and practical experience of basic biochemical and/or immunochemical methods.
Preferably 3 years of experience working with antibodies and/or antigens in a biotech/pharma company.
Experience in affinity chromatography and/or lyophilization.
Problem solving and analytical skills.
Teamwork skills.
Fluent written and spoken English.
Knowledge of LIMS is an advantage.
Knowledge of ISO 9001:2015 and/or GMP is preferable.

Job duties:

Performing manufacturing tasks related to antibody downstream manufacturing processes in accordance with the production plan.
Performing manufacturing task related to other biological materials.
Working in accordance with appropriate SOPs, maintaining quality standards.
Keeping logs to ensure full traceability of the materials and reproducibility of the procedures.
Informing about possible deviations from established procedures or routines, participating in problem solving.
Compliance with workplace safety requirements.
Work is 100% onsite.

Bioprocess technician, Research and Development – Onego Bio

24.8.2024 | Avoimet työpaikat

https://www.jobly.fi/tyopaikka/bioprocess-technician-research-and-development-2166445?source=job_alert&utm_source=job_alert&utm_medium=email&utm_campaign=job_alert&utm_content=job_title

Are you interested in revolutionizing the food system by producing sustainable food ingredients with cutting edge technology and with superb colleagues who are top experts in their field? Onego Bio might be just the place for you.

Onego Bio is a Finnish leading food-biotech company producing animal-free egg protein with precision fermentation. The company’s award-winning technology has placed them at the forefront of the industry, having cracked the code to producing bioidentical egg proteins that provide the same taste, functionality, and nutrition but without the poor efficiency and harmful impacts of animal agriculture. Onego Bio is launching its first product Bioalbumen® as an ingredient for the food industry and transforming the food system to meet the urgent sustainability requirements of the world. The company is focused on scaling precision fermentation to industrial scale with the superior Trichoderma reesei production platform.

Founded by alternative protein pioneer Maija Itkonen (CEO) and precision fermentation trailblazer Christopher Landowski (CTO), Onego Bio is a spin-off that salutes the remarkable work done by VTT Technical Research Centre of Finland for the next level cellular agriculture products and applications. In April 2024 Onego raised a $40M Series A funding round (one of the largest in the Nordics) for fueling scale up and go-to-market in the US. Similarly, in July 2024 Onego secured €14M / $15.2M new funding from the European Innovation Council (EIC) Accelerator Program and additional Series A investors. In 2024 Onego Bio has successfully raised altogether €50.5M / $55M, bringing the company’s total funding to € 65M / $70.8M. Since launching, the company has received massive international recognition, including being selected as a winner of Fast Company’s 2023 World Changing Ideas Awards. Onego Bio is a founding member of Precision Fermentation Alliance US and Food Fermentation Europe. Get to know us better by exploring our webpage www.onego.bio/about-us   

We are now looking for a talented bioprocess technician to join our R&D team in Helsinki, Finland. 

In this position, you will play an essential role in supporting research projects with a bioprocess team and contribute towards our greater goal of providing animal-free egg protein ingredients to the world. We aim to play a significant role in building the sustainable food system with the help of our partners throughout the world. Towards this goal our team utilizes microbial production systems for expressing egg white proteins using filamentous fungi. 

Your responsibilities as Bioprocess technician:  

Supporting bioprocess team by carrying out laboratory work including solution preparation, bioreactor preparation, cultivation experiments, sampling and sample handling, different steps of downstream processing and equipment cleaning and sterilization both in laboratory and pilot scale
Analysis of bioprocess samples, for example hplc, SDS-PAGE and other protein analytics (Bradford)
Keeping an electrical lab notebook and reporting results to scientists 
Help maintaining the research lab facilities and instruments

We are looking for a person who has: 

Completed Bachelor´s degree from University of Applied Sciences or technician´s degree preferably in laboratory or process technology
Experience with solution and media preparation and use of autoclave
Basic knowledge of bioprocess technology, fermentation, and aseptic working techniques  
Eager attitude towards your working tasks and learning new things
Ability to prioritize and execute simultaneous tasks
Sufficient English language skills to document results and follow working instructions

As a person, we hope that you are: 

Skilful and precisely plan and conduct your lab work and follow lab safety protocols and you can schedule your own work between multiple tasks
Self-motivated and willing to take the initiative to get things accomplished  
Have effective communication skills 
Work well with other team members and contribute to a good working environment 
Can tolerate pressure and maintain a good work-life balance  
Available for flexible working hours also: the working hours are mainly among 7,5 h daily work, but if necessary, you can flexibly work outside the office hours
Capable to work with physically heavy loads
Are flexible to take on a variety of tasks anticipated in a start-up company

With Onego Bio, you’ll enjoy: / What we offer you: 

Molecular biology with an impact. Onego Bio is transforming the future of egg production by creating cutting-edge microbial protein production systems. Microbial production technology to produce egg white protein can significantly mitigate environmental impacts according to the LCA study published in Nature Food. The positive impact of our technology does not only contribute positively on the environment but also supply chain stability, global health, food security and animal welfare. Egg is one of the world’s most popular proteins and our team stands to meet the demand in a way that preserves the future of our planet.
Superb colleagues. We offer working in a passionate environment within a fun and diverse team who want to make an impact in the world. With Onego Bio, you will join a dedicated group of top experts in their respective fields who foster a culture of trust, openness, and sharing ideas.
Competitive salary. We want to attract the best people, so we will provide competitive salaries.
Nordic work–life balance. Working in Finland, the happiest country in the world, enables a high quality of life. At Onego Bio, we make our people’s well-being a priority. We offer 6 weeks paid vacation a year, among other benefits including extended occupational healthcare, and exercise and culture benefits

Apply now and join our community of brilliant minds!

Please send your CV and application letter as soon as possible but at the latest by 8th of September 2024. We will process applications as they come in and fill the position as soon as we find the right candidate.

Interested and want to hear more?

For further information, please contact Elviira Kärkkäinen, Head of Bioprocessing, elviira.karkkainen@onego.bio.

Read more about our past work on the topic: 

We look forward to hearing from you!

Doctoral Researcher in the field of Controlling Gene Transcription by Cyclin-dependent Kinases

24.8.2024 | Avoimet työpaikat

https://www.jobly.fi/tyopaikka/doctoral-researcher-field-controlling-gene-transcription-cyclin-dependent-kinases-2166688?source=job_alert&utm_source=job_alert&utm_medium=email&utm_campaign=job_alert&utm_content=job_title

Faculty of Medicine, Barborič laboratory, invites applications for a position of

Doctoral Researcher

in the field of Controlling Gene Transcription by Cyclin-dependent Kinases and their Targeting in Cancer for a fixed-term.

The University of Helsinki is a research-oriented university which offers a stimulating and international environment. The Faculty of Medicine of the University of Helsinki, together with Helsinki University Central Hospital, The Helsinki Institute of Life Science, and the Institute for Molecular Medicine Finland forms the Academic Medical Center Helsinki. This medical campus ranks among the 10 best medical centers at European level and the 50 best centers in the world. More info on the Faculty or Medicine and AMCH can be found here: https://www.helsinki.fi/en/faculty-of-medicine and https://www.helsinki.fi/en/meilahti-campus

The lab’s mission is to unravel fundamental mechanisms that control the elongation phase of transcription by RNA polymerase II (Pol II) in normal and disease states. We are particularly interested in essential and biomedically important transcriptional cyclin-dependent kinases (tCDKs) that trigger release of Pol II from promoter-proximal pausing and facilitate productive Pol II elongation along genes. We aim to exploit the knowledge on basic principles of gene regulation to help devise novel treatments of many diseases that stem from misregulated gene transcription programs. More information about the lab, including the latest research and news, can be found here: https://www.helsinki.fi/en/researchgroups/center-for-gene-regulation

We are looking for a creative thinker with strong analytical skills and a passion for science. We expect you to formulate your own hypotheses, propose experimental design to address them, and take advantage of the laboratory/research community’s intellectual and skill resources to advance the knowledge of the field. The competitive candidate should hold an MSc degree in molecular biology, biochemistry, biotechnology or related fields. Expertise in biochemistry and molecular biology is a pre-requisite for the position. In addition, we appreci-ate fluency in the analysis of NGS data. Strong command in written and spoken English is required.

The appointee must apply, and obtain, the right to pursue a doctoral degree at the University of Helsinki within the probationary period of 6 months: https://www.helsinki.fi/en/admissions-and-education/apply-doctoral-programmes/how-apply-doctoral-education. More info on The Doctoral Programme in Biomedicine and The Doctoral Programme in Integrative Life Science can be found here: https://www.helsinki.fi/en/research/doctoral-education/doctoral-schools-and-programmes/doctoral-school-in-health-sciences.

The successful candidate will receive training in biochemical, molecular biology and cell line-based functional assays, as well as cutting-edge systems biology methods, such as CRISPRi and nascent transcriptomics methods. The training will be furthered by research visits as part of our collaborations with a network of well-regarded laboratories around the globe. Current projects in the lab funded by the 4-year Research Council of Finland grant, 3-year Sigrid Juselius Foundation grant and Cancer Foundation Finland grant, Sigrid Juselius Foundation revolve around fundamental biology of tCDKs and their combinatorial targeting in cancer.

The salary of the selected candidate will be based on the University’s salary scheme for teaching and research personnel composed of task specific and personal performance components. A trial period of six months will be applied.

The University of Helsinki offers comprehensive services to its employees, including occupational health care and health insurance, unemployment and pension fund, a generous holiday package, sports facilities, and opportunities for professional development: https://www.helsinki.fi/en/about-us/careers.

The appointee is expected to reside in Finland while employed by the University of Helsinki. International staff is supported in relocating to Finland: https://www.helsinki.fi/en/about-us/careers/welcome.

Please submit your application, together with a motivation letter including a summary of your research interests, CV, and two letters of reference, through the University of Helsinki electronic recruitment system by clicking on the ’Apply now’ button.

Internal applicants (i.e., current employees of the University of Helsinki) submit their applications by using the Employee Login button.

The University of Helsinki welcomes applicants of any gender, linguistic and cultural background or minority group.

The closing date for application is September 9th, 2024. The shortlisted candidates will be notified about the interview shortly afterwards.

For further information, please contact Matjaž Barborič, Ph.D.; matjaz.barboric(at)helsinki.fi

Recent publications:

Wang Z et al. (2023) Inhibition of CDK12 elevates cancer cell dependence on P-TEFb by stimulation of RNA polymerase II pause release. Nucleic Acids Res 51(20):10970-10991

Wang Z et al. (2023) P-TEFb promotes cell survival upon p53 activation by suppressing intrinsic apoptosis pathway. Nucleic Acids Res 51(4):1687-1706

Bugai A et al. (2019) P-TEFb activation by RBM7 shapes a pro-survival transcriptional response to genotoxic stress. Molecular Cell 74(2): 254-267

PhD in 3 years: Doctoral Researcher in Computational Cancer Biology, ECM-Hypoxia Research Unit

24.8.2024 | Avoimet työpaikat

https://www.linkedin.com/jobs/view/3992495515

About the job

The University of Oulu is a multidisciplinary, international research university, with about 3,600 employees who produce new knowledge based on high-standards research and provide research based education to build a more sustainable, smarter, and more humane world. The University of Oulu community has about 17,000 people in total. Our northern scientific community operates globally and creates conditions for the emergence of innovations.

We are now seeking for a highly motivated and talented

Doctoral Researcher in Computational Cancer Biology

to join the education pilot in precision cancer medicine (iCANDOC) in the research group of Associate Professor Valerio Izzi at the University of Oulu.

In this position, you will participate in the national 1000 doctorates pilot programme which supports the completion of a doctoral degree within three years. As a partner in the programme, the University of Oulu is dedicated to ensuring you have a carefully planned and guided doctoral research experience which will be tailored to support your career plans, enabling you to continue into demanding expert positions in the changing job markets in industry, the public sector and academia.

Job Description

Cancer initiation and progression depend on the interplay between heterogeneous tumor cells and the surrounding tumor microenvironment (TME), consisting of various types of stromal cells and the extracellular matrix (ECM). Our research focuses on understanding the composition and roles of tumor ECM compartments (niches) in modulating cancer cell phenotypes and fates, cancer progression and therapy resistance, at the systems biology level.

The Izzi group (https://github.com/Izzilab) is a leader in developing computational tools for the analysis of ECM in high-dimensional, multi-modal data. As a doctoral researcher in our group, you will participate in developing machine learning/AI algorithms to deconvolute the connections between ECM niches and functional cancer cell states at the single-cell, spatial, and proteomics level. Expectedly, these algorithms will help identifying druggable ECM targets in cancer, which will be validated in our cellular and in vivo cancer models.

As a member of our group, you will access a network of numerous national and international collaborations, which will expose you to state-of-the-art methodologies for ECM research and offer rich opportunities for internships, mobility, and further career development after completion the PhD in three years. The Izzi group is part of the ECM-Hypoxia research unit with six internationally strong research groups.

Who are you?

In order to succeed and enjoy the position, we expect from you:

Master’s or equivalent degree in bioinformatics, biostatistics, data analysis, molecular and cell biology, biochemistry, biomedicine, medicine, or related fields
Excellent command of R and/or Python and advanced knowledge of machine learning and deep learning
Experience with big data analysis (bulk and single-cell RNASeq, proteomics, spatial methods are considered an advantage)
Basic knowledge of cancer cell biology
Fluent in written and spoken English language
Excellent communication and teamwork skills
Full dedication on the research project and ability to meet project deadlines

We also appreciate

Previous experience in teaching
Experience with Shinyapp development
Experience with cell culture and wet lab-based cancer research projects
Please see also the requirements of the University of Oulu Graduate School (UniOGS).

Qualification Requirements

The chosen doctoral researchers will also be expected to apply for doctoral study rights at the University of Oulu Graduate School. Eligibility for study rights will be evaluated during the job application process. We are looking for excellent candidates who must fulfill the following criteria:

Must hold a master’s degree or equivalent degree (e.g. licentiate) in bioinformatics, biostatistics, data analysis, molecular and cell biology, biochemistry, biomedicine, medicine, or related fields
Undergraduate students are eligible to apply provided their Master’s or equivalent degree is finished by 1.1.2025
Must have achieved a good grade in their degree (i.e. at least 60 % of the maximum grade in both taught courses and the master’s thesis)
Must be able to demonstrate English language skills that are sufficient to follow doctoral studies.

What We Offer

A dynamic research environment which promotes personal and professional growth as a scientist The support of two experienced, enthusiastic and multidisciplinary research teams.
A low hierarchy structure focused on teamwork and constant discussion flow.
An inspiring international research atmosphere and smooth entry to national and international ECM research networks.
Structured, interdisciplinary doctoral training.
Work that matters and a workplace that promotes flexibility and work-life balance. Read more about working with us.
Wellness benefit ePassi covering sport, culture and well-being. Read more about other staff benefits.
Our Buddy Programme and Spouse Network support you and close-ones in settling into Oulu.
We have a HR Excellence in Research -quality label which is a recognition awarded by the European Commission for the development of researchers’ working conditions and careers.
Finland is one of the most livable countries in the world, with a high quality of life, safety, excellent education system, and competitive economy. Read more about living in Oulu.

Position and salary

Doctoral researchers selected in the pilot programme will by default be offered a three-year (36 month) fixed-term full-time employment contract by University of Oulu. These positions are available for highly motivated and talented researchers wishing to undertake and complete training for a research-focused doctoral degree, starting 1.1.2025 at the earliest. The selected applicants are expected to start their project no later than 1.2.2025. A six-month trial period is applied in the position.

The salary of the selected doctoral researchers will be paid monthly. The salary will be based on the levels 2-4 of the demand level chart for teaching and research staff of Finnish universities. In addition, a salary component based on personal work performance will be paid (maximum of 50 % of the job-specific component). Starting gross salary will be approx. 2500-2800 € per month (before taxes).

The employment contracts are based on a total working time of 1612 hours per year, which gives the doctoral researchers freedom to plan their working hours.

How To Apply

Applications, together with all relevant enclosures, should be submitted using the electronic application form by 30.9.2024 (23:59 Finnish local time). The application should be written in English and include the following:

Certificates/Diplomas Scanned copy of the original relevant Master’s degree certificates and transcript of records and, when necessary, official translations to Finnish or English.
A motivation letter (max. 2 pages) summarizing applicant’s professional experience and expertise and describing why the applicant is a good fit for this position. Also, information on personal research interests, experience and career plans are valuable to provide here.
Curriculum vitae (max. 2 pages). A recommended CV template can be found on the Finnish National Board on Research Integrity. At the end of the CV, the applicant must include a list of peer-reviewed scientific publications with full reference details. The number of pages of the publication list doesn’t concur to the max. 2 page-limit of the CV.
Research plan (max. 4 pages) The research plan should mostly contain information about the planned use of algorithms (which? why? how?) to tackle the research questions mentioned in the Job Description section. The ability to envision how the use of such methodologies could advance the study of ECM niches in cancer is considered an advantage. Applicants to this position are encouraged to contact Prof. Valerio Izzi and Dr. Ritva Heljasvaara before and/or while preparing this document.
A valid certificate or other demonstration of language proficiency.

Only applications containing all relevant appendices and submitted through the online recruitment system will be considered. Applications received after the call deadline will not be considered.

We welcome applicants from all backgrounds, including people of different ages, genders, and linguistic, cultural, or minority groups.

Evaluation

Applications will be evaluated according to the suitability of the candidate and the proposed research plan for the job description, competence, motivation, commitment and career plan. Applicants with excellent records in these areas will be invited to an online interview where the above criteria as well as professional experience and language proficiency will be reviewed. All candidates will be scored jointly by Prof. Valerio Izzi and Dr. Ritva Heljasvaara and the best candidate will be offered the position. All applicants will be informed at the different steps of the process.

Further information

For further information, please contact Valerio Izzi (valerio.izzi@oulu.fi) or Ritva Heljasvaara (ritva.heljasvaara@oulu.fi)

Postdoctoral Researcher in the field of Controlling Gene Transcription by Cyclin-dependent Kinases

24.8.2024 | Avoimet työpaikat

https://www.jobly.fi/tyopaikka/postdoctoral-researcher-field-controlling-gene-transcription-cyclin-dependent-kinases?source=job_alert&utm_source=job_alert&utm_medium=email&utm_campaign=job_alert&utm_content=job_title

Faculty of Medicine, Barborič laboratory, invites applications for a position of

Postdoctoral Researcher

in the field of Controlling Gene Transcription by Cyclin-dependent Kinases and their Targeting in Cancer for a fixed-term.

We are looking for a creative thinker with strong analytical skills and a passion for science. We expect you to formulate your own hypotheses, propose experimental design to address them, and take advantage of the laboratory/research community’s intellectual and skill resources to advance the knowledge of the field. The competitive candidate should hold a PhD degree in molecular biology, biochemistry, biotechnology or related fields. Expertise in biochemistry and molecular biology is a pre-requisite for the position. In addition, we appreciate fluency in the analysis of NGS data. Strong command in written and spoken English is required.

The successful candidate will receive training in a comprehensive set of biochemical, molecular biology and cell line-based functional assays, as well as cutting-edge systems biology methods, such as CRISPRi and nascent transcriptomics methods. The training will be furthered by research visits as part of our collaborations with a network of well-regarded laboratories around the globe. Current projects in the lab funded by the 4-year Research Council of Finland grant, 3-year Sigrid Juselius Foundation grant and Cancer Foundation Finland grant, Sigrid Juselius Foundation revolve around fundamental biology of tCDKs and their combinatorial targeting in cancer.

Please submit your application, together with a motivation letter including a summary of your research interests, CV, list of publications and two letters of reference, through the University of Helsinki electronic recruitment system by clicking on the ’Apply now’ button.

Internal applicants (i.e., current employees of the University of Helsinki) submit their applications by using the Employee Login button.

The University of Helsinki welcomes applicants of any gender, linguistic and cultural background or minority group.

The closing date for application is September 9th, 2024. The shortlisted candidates will be notified about the interview shortly afterwards.

For further information, please contact Matjaž Barborič, Ph.D.; matjaz.barboric(at)helsinki.fi

Recent publications:

Doctoral Researcher positions, Doctoral Programme in Molecular Medicine

24.8.2024 | Avoimet työpaikat

https://www.linkedin.com/jobs/view/3992495511

About the job

We are inviting applications for a total of 15 Doctoral Researchers to the doctoral programmes of the Faculty of Health Sciences. The positions will be hosted by the Faculty of Health Sciences on the Kuopio campus and will start on 1 January 2025 (or by the end of 2025 as agreed). Please find more information below, and submit your application by 26 August 2024.

Role and salary

Through this call for applications, you can apply for a Doctoral Reseacher position in the Doctoral Programme in Molecular Medicine (DPMM), which is an interdisciplinary doctoral training program with the purpose of training researchers as international experts in modern biomedicine. Molecular medicine studies the causes and mechanisms of origin of diseases on a molecular level and strives to find methods to treat and prevent these diseases. The research areas in DPMM are cardiovascular diseases, neurosciences, type 2 diabetes and obesity, stem cell research, inflammatory diseases, and cancer.

The duties of a Doctoral Researcher include conducting research related to their doctoral dissertation in accordance with their approved research proposal. The aim is to complete the doctoral degree in four years of full-time study, regardless of the funding source.

Doctoral Researcher positions are filled for a maximum of three years starting from 1 January 2025 (or by the end of 2025 as agreed). In fulfilling these tasks, previous Early-stage Researcher/Doctoral Researcher positions will be considered regardless of the funding source. A trial period is applied to new holders of a position. The position is filled for a fixed term due to doctoral dissertation work related to postgraduate studies.

The position of a Doctoral Researcher may be applied for either on a full-time or a part-time basis. Part-time Doctoral Researcher positions must be co-financed with some other funding source (for example, an external grant administered outside the university that can be combined with the employment contract or a part-time employment contract with another organisation), so that the total amount of funding enables the candidate to work full-time on their doctoral dissertation. Individual months as a Doctoral Researcher may also be applied for.

The salary of the post is based on the salary system for the teaching and research staff of Finnish universities. The salary consists of a job-related salary element and a personal salary element. In this position, the job-related salary element is based on level 2–4 (EUR 2,225.83 – 2,775.28/month) of the job requirement level chart, depending on the stage of the applicant’s doctoral research and postgraduate studies. In addition, a personal salary element is paid, which is 6-50% of the job-related salary element.

We expect you to

to be qualified to pursue postgraduate studies; you hold a relevant Master’s degree awarded by a university or by a university of applied sciences, or a relevant applicable study programme abroad which in the awarding country gives eligibility for the corresponding level of higher education,
have good skills in the English language,
meet the student admission criteria for the doctoral programme,
be planning or doing your first doctoral degree,
be a postgraduate student registered with the University of Eastern Finland or plan to complete your doctoral dissertation at the University of Eastern Finland.
In addition, the duration of your (full-time) doctoral research must not exceed four years by 31 December 2024.

We offer you

an interesting position in an international, creative, participatory and inclusive university community,
the opportunity for flexible multi-location work,
the staff benefits of the University of Eastern Finland, including comprehensive occupational health care, extensive provision of staff training, affordable lunch in our campus restaurants, and Sykettä sports services, a tax-free bike benefit.

How To Apply

Submit your application by using our electronic application form no later than 26 August 2024 by 24:00 (midnight) Finnish time (UTC+3). The Doctoral Researcher position must be applied for in the doctoral programme to which you have applied/will apply for a postgraduate study right at the University of Eastern Finland.

Please note that the applications must contain the following appendices in English (in pdf-format):

A curriculum vitae (Template for CV, www-page).
A publication list specifying the publications to be included in your doctoral dissertation, if not included in the curriculum vitae (Instructions for a list of publications, www-page).
A research proposal including a research funding plan describing the resources required and existing for the research as well as a brief description of the relevance/impact of the research. Persons who are already registered as postgraduate students must submit an updated research proposal, including a report on the progress of their doctoral research and the intended schedule for the completion of the doctoral research and the initiation of the pre-examination process. Max. 3 pages without references. (Instructions for a research plan, pdf).
A motivational letter (1 page), in which the applicant describes their motivation to pursue postgraduate studies and to conduct research.
A copy of the degree certificate and a transcript of academic records that prove the applicant’s eligibility for postgraduate studies if the person does not have an existing right to pursue postgraduate studies at the University of Eastern Finland.

Only applications that contain all appendices specified in the call will be evaluated and taken into account in the selection. Applications will be evaluated based on uniform criteria, utilising external experts.

The criteria: the quality, clarity, and innovativeness of the research proposal, the feasibility of the research proposal as a doctoral dissertation, the applicant’s evidence of previous research projects and the applicant’s motivation based on the motivation letter.

The evaluation may include an interview. The objective is for the faculty to decide on the candidates to be appointed to the positions by mid-November.

Questions?

healthpostgrad@uef.fi

Terveystieteiden tiedekunta toimii Itä-Suomen yliopiston Kuopion kampuksella. Tiedekunnassa koulutetaan lääkäreitä, hammaslääkäreitä, ravitsemusterapeutteja, farmaseutteja ja proviisoreja sekä muita keskeisiä asiantuntijoita terveydenhuollon eri aloille. Tiedekunta on hyvin tutkimusintensiivinen. Kansainvälisesti korkeatasoinen ja monitieteinen tutkimus kytkeytyy vahvasti yliopiston strategiassa tunnistettuihin tutkimusalueisiin. Tiedekunnassa on noin 3090 perustutkinto-opiskelijaa ja noin 580 jatko-opiskelijaa. Henkilökuntaa tiedekunnassa on 800.

Itä-Suomen yliopisto (UEF) on Suomen monialaisin tiedeyliopisto. Yliopistossamme työskentelee noin 3 200 työntekijää, ja yhteisöömme kuuluu noin 16 000 tutkinto-opiskelijaa ja 16 000 aikuisopiskelijaa. Kampuksemme toimivat Joensuussa ja Kuopiossa. Tutkimuksemme on useilla aloilla maailman kärkeä, ja tuotamme tutkittua tietoa avoimesti käytettäväksi ja kaikkien hyväksi. Tutustu yliopistoomme verkossa www.uef.fi. Tutustu myös yliopistoon työyhteisönä ja työnantajana sekä työntekijöidemme uratarinoihin.

Account Manager, Life Science Sales – Finland, QIAGEN

24.8.2024 | Avoimet työpaikat

https://www.linkedin.com/jobs/view/3994698465

About the job

Position Description

QIAGEN has an exciting new vacancy for an Account Manager in Finland, preferably living in the Helsinki area. Our sales team work with Life Sciences customers, primarily within academia, to facilitate a customer-centric service and provide them with Sample to Insight solutions. We are looking for an Account Manager to drive and grow sales across the QIAGEN portfolio, supporting customers in the whole of Finland.

The Account Manager will be key in shaping and aligning customer requirements with the ideal QIAGEN solutions. You will be responsible for protecting, growing and proactively searching for new business within the territory for Life Sciences.

Key responsibilities:

– Maintain contact with existing customers as well as develop new customers in order to achieve or exceed sales objectives.

– Achieve or exceed objectives by actively selling to end users primarily at customer sites. Develop a working knowledge of current and potential activities that may affect revenues; Attend sales meetings.

– Regularly report and forecast relevant market figures for sales management and organise and support at seminars and conferences.

– Act as a champion for certain business areas.

– Utilize the CRM database to input and provide information that will increase effectiveness and aid sales.

Position Requirements

– Strong scientific background – ideally qualified to MSc level or higher in a Life Science subject with a proven aptitude for laboratory techniques. Knowledge in molecular biology. Sales experience within Life Science business is an advantage.

– Fluent Finnish and English essential, with excellent listening, verbal, and written communication skills at all business levels.

– Self-motivated with the ability to work in collaboration with field sales representatives and application specialists and with excellent organisational and time management skills.

– Willingness and availability to travel to visit customers up to 80% including occasional overnight travel. Travel will be mostly within Finland but also in Europe/Nordic regions for trainings and sales meetings; Driving license essential.

This position is home-based. However we have an office hub in Helsinki where the whole Finnish team meet regularly.

What we offer

At the heart of QIAGEN are our people who drive our success. We act with passion, always challenging the status quo to drive innovation and continuous improvement. We inspire with our leadership and make an impact with our actions. We create a collaborative, safe and engaging workplace which forms the basis for high performing individuals and teams. We drive accountability and entrepreneurial decision-making and want you to excel your growth and shape the future of QIAGEN.

QIAGEN is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, or disability.

Ajankohtaista

Research Coordinator

About the job

About the job

About the job