Postdoctoral Researcher in Structural Biology of innate immune response in modulation of neuronal synapse loss in Alzheimer’s disease/neurodegeneration
The HiLIFE – Institute of Biotechnology at the University of Helsinki, renowned for its international research excellence, is excited to announce an opening for a postdoctoral researcher to join the group of Dr. Tommi Kajander
Project Description
The research in this project is focused on structural biology and biophysics of protein interactions in neuronal synapse function and in regulation of synapse loss in Alzheimer’s disease (AD) by the complement system (see e.g Chernyaeva et al. EMBO Reports (2023)). We have long standing interest in complement research (e.g. Kajander et al. PNAS (2011); Bhattacharjee et al. J Biol Chem (2013)), and synaptic adhesion (e.g. Karki et al. Sci Reports (2020), Kim et al. PNAS (2022)). Other projects in the group focus currently e.g. on endoplasmic reticulum stress response regulation, and overall on the HiLIFE protein crystallization core facility operation and related projects.
The successful candidate will work on protein production and molecular interaction studies of complement proteins protective of neuronal synapses in AD, in collaboration with Dr. Karita Haapasalo’s group at the medical faculty. Specifically, protein-protein interactions of complement proteins and ApoE and synaptic proteins will be studied biophysically, biochemically, and by structural biology methods to visualize at the atomic level the protein interactions involved in the complement function at the synapse in disease states.
About you
• You are ambitious, goal-oriented, collegial and motivated to tackle challenging new projects
• Have PhD degree in (or in final stages to submit) in protein biochemistry/molecular biology/molecular biophysics.
• Prior experience in protein biochemistry and expression and purification (FPLC) and molecular biology is essential
• Expertise in some degree of cell culture work (e.g. insect cell expression) and molecular biophysics is desired
• High interest in learning/knowledge of structural biology techniques (X-ray crystallography and CryoEM)
• Commitment to scientific excellence as demonstrated by a publication record
• Excellent command of English (working language at the institute)
• Strong communication, interpersonal, organizational and time management skills
What we offer
• A fixed-term 2-year position with possible extension
• A collaborative, innovative and inclusive work environment
• Support and mentoring for postdoctoral fellowship applications
• A competitive salary depending on your qualifications and personal performance, 5-7 weeks of annual holiday leave, flexible working hours
• Financial support with Finnish visa and residency permits, if applicable
• Occupational health care and access to high-quality sports facilities
About the Institute of Biotechnology, HiLIFE, University of Helsinki
The Institute of Biotechnology is an independent research institute within the Helsinki Institute of Life Science (HiLIFE), at the University of Helsinki, Finland, and at the global forefront of life science research with state-of-the-art research core facilities in genomics, biological imaging and structural biology. According to the 2024 Times Higher Education World University survey, the University of Helsinki is ranked among the top 80 universities worldwide in life science research. The University of Helsinki is committed to providing a welcoming environment for international researchers, offering comprehensive services and support for relocating to Finland—a country known for its high quality of life, excellent education system, and robust support for research and innovation.
How to apply?
Welcome with your application in English (click the ‘apply’ link), as soon as possible or no later than 30.6. Please note that applications will be continually reviewed. The position is available from 1st of September or according to mutual agreement. Applications should include a cover letter, CV, and contact details of three references. For further information (not applications) on the position, please contact Dr. Tommi Kajander (tommi.kajander at helsinki.fi).
We are seeking a doctoral researcher to join the Photosynthetic Microbes group led by Professor Yagut Allahverdiyeva. The positions are part of the PhotoFactory consortium, which has recently received > 2.2 Mil EUR from the ErkkoFoundation. The positions will be based in the Faculty of Technology within the Department of Life Technologies in Turku, Finland. Employment starts on 1.8.2024, or as agreed upon. The successful doctoral researcher will be offered a fixed two-year contract, with the possibility of extension until the completion of the PhD thesis.
About the Photosynthetic Microbes Research Group: We are studying the regulation of photosynthesis and applying photosynthetic principles to develop sustainable biotechnologies. The research areas encompass various aspects, including the understanding of alternative electron transport routes, utilizing photosynthetic microbes as biocatalysts for production of solar chemicals (including photoH2), biophotovoltaics (BPV) and developing solid-state photosynthetic cell factories, as well as large-scale algae cultivation for phytoremediation and the production of solar chemicals (such as biostimulants and biopesticides). The PhotoMicrobes group is involved in several EU, Nordic, and national projects and regularly publishes research outcomes in hihghly respected journals. We have established a large research network with connections to well-known international laboratories and industrial partners. Our team members not only active participants in international conferences but also regularly organise symposia and conferences (e.g. Nordic Photosynthesis Congress and the Nordic Algae Symposium). In addition, we have several talented post-doctoral and senior researchers who will provide step-by-step guidance to the PhD students in the lab.
To learn more about the Photosynthetic Microbes research group, you can visit our website at www.utu.fi/photo-microbes or follow us on LinkedIN and Twitter at @PhotoMicrobes.
Job description
Our group is pioneering cutting-edge technology for photosynthetic production of chemicals and fuels using 3-D printed biocatalysts, also known as solid-state photosynthetic cell factories. For this purpose, we are developing intelligent matrices comprising photosynthetic cells and functional nanomaterials integrated with a network of sensors for monitoring and controlling photosynthetic production. The PhD student will play a pivotal role in establishing infrastructure for AI-assisted cultivation and developing protocols for data collection, processing, and digitalization, enabling data-driven modelling and optimization. The PhD project involves a close collaboration with Prof. Milica Todorovic, head of the Materials Informatics Laboratory at the University of Turku. Her research combines artificial intelligence algorithms and first-principles simulations with the objective to optimize functional materials and their performance in devices.
Apply between 6 May 2024 and 1 July 2024 16:00 (Europe/Helsinki)
Who we are looking for
We seek a highly motivated candidate with a passion for sustainability and a keen interest in data-driven systems at the edge of cross-disciplinary technologies. The ideal candidate should possess a robust background in data-driven systems and artificial intelligence, along with experience in programming, data collection, and organization. Knowledge of photosynthesis, microalgae or cyanobacteria would be advantageous.
Applicants should have an MSc in data sciences, or related fields (a good GPA is considered). If you have not completed your MSc, you can still apply and start as a Research Assistant until the MSc degree is completed, and you are accepted to the UTUGS graduate school. Proficiency in written and verbal English communication is essential for this position.
Our selection criteria are based on the principle of finding the most qualified and suitable candidate for the positions. In practice, this means that not only education, scientific merits and working experience but also personal qualities, communication, motivation, and other relevant criteria will be considered.
Benefits
We offer you responsible and interesting tasks and the opportunity to develop your professional skills in a versatile operating environment. You get a professional and inspiring team to support your work. We take care of your well-being at work and the functionality of your everyday life, e.g. with the help of flexible working hours and our well-being services.
Please read more about University of Turku as an employee from our Come work with us! pages.
The European Commission has awarded the University of Turku the right to use the HR Excellence in Research logo. The logo is a token of the University’s commitment to continuous development of the position and working conditions of researchers according to the guidelines set forth in the European Charter for Researchers.
The university offers good support and orientation for international hires. Please learn more about the Finnish culture and relocation to Finland:
The salary is determined by the collective agreement system of the Finnish universities. The positions belong to our research personnel and the salary for a Doctoral Researcher or a Project Researcher is in the range of 2500–2600 €/month and for a Research Assistant in the range of 2200 – 2300 €/month on average and the trial period is 6 months.
Please write your application and accompanying documents in English.
Applicants should enclose with their application:
motivation letter, including statement of motivation, summarizing scientific work and research interest (max 1 page)
CV, including education, positions, professional experience, names and contact details of two academic referees (max 2 pages)
list of publications (please do not attach your thesis or papers)
degree certificate(s) in English or in Finnish
For further information about the position, please contact: professor Yagut Allahverdiyeva, allahve(at)utu.fi
With questions about the application process, please contact: HR-specialist Paula Luoma paula.luoma(at)utu.fi
This is an enriching job opportunity in a rapidly evolving field – we warmly welcome you to join our multicultural working community.
Suomen Solubiologit ry:n hallituslaisten esittelyvuorossa on tällä kertaa aina niin aurinkoinen Anna Aalto (Åbo Akademi University), jonka saimme onneksi pitää hallituksessa mukana 😍 Anna on myös Solubiologi-lehtemme mainostoimittaja, ja on siinä hommassa aivan tykki!
”Heips! Åbo Akademista valmistunut #solubiologi, joka ei ole kotikaupunkia pidemmälle päässyt. Väikkärini jälkeen olen jatkanut tutkimuksia Met1-kytketyn ubikitinaation roolista immuunivasteen välityksessä, ja ilokseni saan käyttää banaanikärpästä koe-eläimenäni. Hauskinta ja antavinta SSB:n hallitustyoskentelyssä on mahdolllisuus tuoda kaikkia Suomen Solubiologit hieman lähemmäksi toisiaan 😊 Toimin myös jäsenlehden mainostoimittajana, eli jos haluat mainostaa lehdessä, niin paas tulemaan viestiä!
Hej! Jag är en cellbiolog från Åbo Akademi, som aldrig kommit längre bort från min kära hemstad Åbo. Efter att jag blivit klar mer mina doktrosstudier har jag fortsatt med att studera Met1-kopplad ubikvitinering och dess roll i bananflugans immunsignalering. Det mest roliga och givande med att jobba i SSB:s styrelse är att jag har en möjlighet att förkorta distansen mellan cellbiologer i Finland 😊 Jag är även medlemstidningens reklamredaktör, så ifall du har extra pengar på dig och vill lägga med en reklam i tidningen, så är det bara att slå en signal”
**
This time in the spotlight for The Finnish Society for Cell Biology board member introduction is the always so cheerful Anna Aalto from Åbo Akademi University, who we could fortunately keep on our board 😍 Anna is also the advertising editor for our ”Cellbiologist” journal, and she’s absolutely amazing at it!
”Hello! I am a Cell Biologist graduated from Åbo Akademi, who hasn’t ventured far from hometown. After my PhD, I have continued my research on the role of Met1-linked ubiquitination in mediating immune responses, and to my delight, I get to use the fruit fly as my model organism. The most fun and rewarding part of working on the board of the Finnish Society for Cell Bilogy is the opportunity to bring all Finnish cell biologists a bit closer to each other 😊 I also serve as the advertising editor for the member journal, so if you want to advertise in the journal, feel free to send me a message!”
#SuomenSolubiologit ry:n vuoden 2024 hallituslaisten esittelyt jatkuvat, ja tänään on vuorossa uusi hallituslainen, Katri Ketola Jyväskylän yliopistosta 😍
”Heippa! Olen syksyllä 2023 Jyväskylän yliopistosta valmistunut solu- ja molekyylibiologian maisteri. Ensikertalainen SSB:n hallituksessa, mutta hallitushommista olen jo konkari ainejärjestöni puolelta. Tällä hetkellä työskentelen tutkimusavustajana Jyväskylän yliopistossa sekvensointivalmistelujen parissa.”
Vielä kerran, tervetuloa hallitukseen Katri! Rautaisia hallitus- ja yhdistysosaajia tarvitaan aina 😊
#Presenting the 2024 board members of the #FinnishSocietyForCellBiology continues, and today we introduce completely new board member, Katri Ketola from the University of Jyväskylä 😍
”Hello! I graduated in the fall of 2023 with a master’s degree in #cell and #MolecularBiology from the University of Jyväskylä. This is my first time on the board of the Finnish Society for Cell Biology, but I am already experienced in board work from my student organization. Currently, I am working as a research assistant at the University of Jyväskylä, working with sequencing.”
Once again, welcome to the board, Katri! People having board and society skills are always needed and very welcome😊
We had super interesting afternoon today at Biosafe, many thanks to Pauliina Halimaa and Pilvi Ruotsalainen for accommodating us! During this company visit, we got a chance to visit Biosafe laboratory facilities and then hear more about the company activities. We also had few participants via Zoom. It was a pleasure to also have Pilvi sharing her career path into current position as a Project manager in the #microbiology team, because Pilvi is the former board member of our society. This really made the visit even more special😊 Thank you! #FinnishSocietyForCellBiology #SuomenSolubiologit
The Faculty of Agriculture and Forestry at the University of Helsinki invites applications for the position of a Doctoral researcher in Food Microbiology/Food Science
The Doctoral researcher will be appointed for a fixed-term 2-year contract (start date: 1 September 2024 or as agreed) to work in a project entitled “HealthFerm- Innovative pulse and cereal-based food fermentations for human health and sustainable diets” more information at https://www.healthferm.eu/ . The position will be supervised by University Lecturer Rossana Coda , at the Faculty of Agriculture and Forestry.
Fermented foods are widely consumed in Europe and across the globe because of their sensory characteristics, cultural value and – especially in the past few decades – nutritional and perceived health benefits. However, knowledge on the impact of food fermentation on human health and mechanisms behind such impact is limited due to the lack of dedicated and integrated studies. Such knowledge is required to start designing fermented foods with optimal health benefits instead of relying on spontaneous fermentation processes. Such designed foods will preferentially be plant-based (grain-based) as a shift from diets rich in animal-based products to plant-based diets is key in transitioning towards a more sustainable global food system. Fermentation technology provides opportunities to overcome the challenges associated with the incorporation of plant-based raw materials and, hence, supports the required shift. Rational design will require novel microbial resources and rethinking the approach towards food fermentations.
Doctoral researcher : We are looking for a highly motivated and skilled researcher with a Master’s degree and experience in food microbiology, food science, or related field.
A successful candidate should be able to:
Identify, design, conduct, and report research within the scope of the project.
Contribute to undergraduate student supervision and teaching within the department.
Engage with the scientific community, research partners and the wider public, internationally and domestically through scientific publications, conference presentations, press releases, blogs etc.
The candidate is expected to have:
Education, Experience And Technical Skills
A relevant Master’s degree including experience in food microbiology/microbiology/food science.
Fluency in English and excellent writing skills.
Experience in working with basic microbiological techniques.
Personal attributes and competencies
Interest in basic and applied food science/food microbiology.
Excellent analytical and innovative research planning skills.
Experience in microbial cultivation, phenotyping, PCR methods, and fermentation
Excellent interpersonal and communication skills, experienced in working within multicultural and multidisciplinary teams.
High motivation for academic research, having initiative and capable of working independently as well as in team environments.
Values continuous improvement based on constructive evaluation, self-reflection and learning.
The appointee should either already have the right to pursue a doctoral degree at the University of Helsinki by the start of the appointment or apply for the right and obtain it within the probationary period of six months of their appointment. If the candidate does not already have the right to pursue a doctoral degree at the University of Helsinki, it must be applied for separately, please see: https://www.helsinki.fi/en/research/doctoral-education/the-application-process-in-a-nutshell
The starting salary of the Doctoral researcher will be based on level 2 of the demands level chart for teaching and research personnel in the salary system of Finnish universities. In addition, the appointee will be paid a salary component based on personal performance. The starting salary of the Doctoral researcher will be ca. 2400-2600 euros/month, depending on the appointees’ qualifications and experience. A six-month trial period will be applied.
The University of Helsinki offers comprehensive services to its employees, including occupational health care and health insurance, unemployment and pension fund, a generous holiday package, sports facilities, and opportunities for professional development. A six-month trial period will be applied.
How To Apply
Please submit your application as A SINGLE PDF FILE in English using the University of Helsinki Recruitment System.
A cover letter explaining your motivation for the research work and a short research plan (e.g. approach, research materials and methods) (up to 3 pages).
Curriculum vitae showing your education, completed qualifications, work experience, possible list of publications and contact information of 2 persons for references (up to 3 pages). In your CV, please state clearly your experience in microbial cultivation, phenotyping, PCR methods, and fermentation
Copies of Master’s, and Bachelor’s degree certificates and official transcripts of the records, and their translations, if the originals are not in Finnish, Swedish or English.
External applicants, please submit your application using the University of Helsinki Recruitment System via the Apply Now button.
Applicants who have a helsinki.fi username and a valid employment contract, a grant researcher’s contract or a visiting researcher’s contract at the University of Helsinki are requested to leave their application by using the Employee Login button.
The University of Helsinki welcomes applicants from a variety of genders, linguistic and cultural backgrounds.
The closing date for applications is 10 June 2024 at 23:59 EEST.
Further information
About the position: University Lecturer Rossana Coda, rossana.coda@helsinki.fi
Support for international staff: https://www.helsinki.fi/en/about-us/careers/welcome and https://ihhelsinki.fi (International House Helsinki)
About Us
The Faculty of Agriculture and Forestry is located on the Viikki campus, ten kilometres from the Helsinki city centre.The mission of the faculty is to promote the sustainable use of renewable natural resources through scientific research and research-based teaching. We focus on agricultural and forest sciences, food and nutrition, microbiology, as well as on economics and management. We cover the full natural resource chain from farm to fork, the entire field of forest sciences from soil chemistry to marketing, as well as the environmental effects of related activities. Graduates from the Faculty of Agriculture and Forestry are versatile experts in biosciences and business, able to meet the needs of both the business sector and society at large.
The Department of Food and Nutrition is the largest food campus in Finland and provides a dynamic and innovative environment for education and research. The Department has strong chemistry and microbiology expertise. The competence in biotechnologies applied to plant-based food, such as cereals, faba bean, and side-streams, has led to participation to large national and international projects, putting UH team at the forefront of EU research.
Most of the members working in HealthFerm belong to the Grain Technology group. The group studies and imparts knowledge on the physical and chemical characteristics of cereal grains and grain legumes. Its goal is to contribute to the development of wholesome, delicious foods for the world’s expanding population. Beta-glucan and other cereal fibers, cereal and pulse proteins, flavor, fermentation and bioprocessing of grain-based raw materials, and grain safety are the main areas of its current research.
Turku Bioscience Centre has an open position for a postdoctoral and/or doctoral researcher. The position is for two years, with a possibility for extension. The start date is September 1st 2024, but is negotiable.
Turku Medical Bioinformatics Centre (https://elolab.utu.fi) at Turku Bioscience Centre is looking for a postdoctoral or doctoral researcher for projects that identifies molecular factors and their regulatory networks involved in human diseases. Using large-scale omics datasets and computational methods, the project studies, how the human immune system functions and how this understanding could be utilized in developing new treatments for immune-mediated diseases and cancer. The research employs statistical and machine learning methods as well as bioinformatics tools. The project is carried out in close collaboration with biomedical research teams.
Job description
The tasks include both the analysis of omics data (e.g. single-cell profiling, proteomics) and the testing and further development of data analysis methods. The focus can be tailored according to the expertise and interests of the applicant. Additionally, the position involves collaboration with multidisciplinary research teams and following the rapidly developing latest methods in the field.
Apply between 7th of May 2024 and 12th of June 2024 16:00 (Europe/Helsinki)
Who we are looking for
The applicant is required to have a PhD or MSc degree in a suitable field (bioinformatics, biostatistics, data science, computer science or similar). We may also consider applicants who have not yet completed their MSc studies, but are graduating soon.
We are looking for a researcher with a proficient understanding of bioinformatics tools and good programming skills (e.g. R, Python). The position requires a proactive approach in problem solving, self-direction and good cooperation skills. Fluent oral and written English is essential.
The job title of MSc level applicant will be specified during the recruitment phase. If the applicant has the right to study for a doctoral degree at University of Turku, the job title is doctoral researcher. Otherwise, the job title is project researcher or a research assistant.
We consider as a plus
• Experience in proteomics or single-cell data analysis
• Research experience in the field of biomedicine
We value equality and diversity in our work community and encourage qualified applicants, regardless of background, to apply for our open positions.
Benefits
• Top-level research environment
• Access to state-of-the-art facilities, resources, and unique high-quality datasets
• An excellent working community
• Versatile and varied tasks
• Flexible working hours
• Support for continuous professional development
Please read more about University of Turku as an employee from our Come work with us! pages.
The European Commission has awarded the University of Turku the right to use the HR Excellence in Research logo. The logo is a token of the University’s commitment to continuous development of the position and working conditions of researchers according to the guidelines set forth in the European Charter for Researchers.
The university offers good support and orientation for international hires. Please learn more about the Finnish culture and relocation to Finland:
The salary is determined by the collective agreement system of Finnish universities, aligning with the research personnel category. The demand level of the postdoctoral researcher position is 5 and the doctoral researcher position 2 – 3. In addition, a salary component based on personal performance is paid. The average monthly salary, depending on previous experience and skills, is around 3450 – 3800 euros per month for postdoctoral researcher and around 2400 – 2900 euros per month for doctoral researcher/project researcher at the beginning of the employment.For a research assistant the salary will be 2200 – 2300 euros per month.
The position is subject to a six (6) month trial period.
How to apply
Please submit your application through our online recruitment system. Applications may already be processed during the application period.
Applicants should enclose with their application:
motivation letter (max. one page)
CV
list of publications, if applicable
degree certificate(s) / a transcript of records
contact information of two referees
other documents that may influence the filling of the position
Are you interested in shaping the future of food by producing new sustainable food ingredients with cutting edge technology and with superb colleagues who are top experts in their field? Onego Bio might be just the place for you.
Onego Bio is a Finnish leading food-biotech company producing animal-free egg protein with precision fermentation. The company’s award-winning technology has placed them at the forefront of the industry, having cracked the code to producing bioidentical egg proteins that provide the same taste, functionality, and nutrition but without the poor efficiency and harmful impacts of animal agriculture. Onego Bio is launching its first product Bioalbumen® as an ingredient for the food industry and transforming the food system to meet the urgent sustainability requirements of the world. The company is focused on scaling precision fermentation to industrial scale with the superior Trichoderma reesei production platform.
Founded by alternative protein pioneer Maija Itkonen (CEO) and precision fermentation trailblazer Christopher Landowski (CTO), Onego Bio is a spin-off that salutes the remarkable work done by VTT Technical Research Centre of Finland for the next level cellular agriculture products and applications. In April 2024 Onego raised a $40M Series A funding round (one of the largest in the Nordics) for fueling scale up and go-to-market in the US. Since launching, the company has received massive international recognition, including being selected as a winner of Fast Company’s 2023 World Changing Ideas Awards. Onego Bio is a founding member of Food Fermentation Europe and Precision Fermentation Alliance US. Get to know us better by exploring our webpage www.onego.bio/about-us
We are now looking for an experienced Research Scientist to join our R&D team
In this position, you will play an essential role in developing, planning, and carrying out research projects with a project team and contribute towards our greater goal of providing animal free egg protein ingredients to the world. Ultimately, we aim to be part of building a sustainable food system with the help of our partners throughout the world. Towards this goal our R&D team will create microbial production systems for expressing egg white proteins using filamentous fungi.
Your responsibilities as Research Scientist:
Scientific project work in the fields of molecular biology, protein production and fungal biology.
Using your expertise in molecular biology and strain engineering to create excellent fungal production strains for egg white proteins.
Developing strain screening technologies and workflows for filamentous fungi.
Further developing our fungal expression platforms using the newest innovations.
Working with our bioprocess team to improve the strains and bioprocess conditions.
Who we are looking for:
Proven, excellent laboratory skills and experience in molecular biology techniques such as DNA cloning, genome engineering, protein analysis, protein purification, and possibly genome analysis.
Completed MSc or PhD in biotechnology, molecular biology, or related field.
One year or more of experience working with filamentous fungi, or possibly yeast.
Good scientific reporting skills.
Good written and spoken English skills.
Industrial experience working in a biotechnology company would be a big plus.
As a person, we hope that you:
Skillfully and precisely plan and perform experiments.
Self-motivated and willing to take the initiative to get projects accomplished.
Have strong communication and collaboration skills.
Work well with other team members and contribute to a good working environment.
Can tolerate pressure and maintain a good work-life balance.
Are flexible to take on a variety of tasks anticipated in a start-up company.
At Onego Bio, you’ll enjoy:
Molecular biology with an impact. Onego Bio works on creating cutting-edge microbial protein production systems. Microbial production technology to produce egg white protein shows potential to significantly mitigate environmental impacts up to 90% according to recent study published in Nature Food. The positive impact of our technology does not only contribute positively on the environment but also supply chain stability, global health, food security and animal welfare. Egg is one of the world’s most popular proteins and our team stands to meet the demand in a way that preserves the future of our planet.
Superb colleagues. We offer working in a passionate environment within a fun and diverse team who want to make an impact in the world. With Onego Bio, you will join a dedicated group of top experts in their respective fields who foster a culture of trust, openness, and sharing ideas.
Competitive salary. We want to attract the best people, so we will provide competitive salaries.
Nordic work–life balance. Working in Finland, the happiest country in the world, enables a high quality of life. At Onego Bio, we make our people’s well-being a priority. We offer 6 weeks paid vacation a year, among other benefits including extended occupational healthcare, and exercise and culture benefits.
Apply now and join our community of brilliant minds!
Please send your CV and application letter as soon as possible but at the latest by 16th of June 2024. We will process applications as they come in and fill the position as soon as we find the right candidate.
Interested and want to hear more?
For further information, please contact Head of Biology, Taija Leinonen +358 44 493 8253 on 21.05.2024 at 10:30 – 11:00 and on 11.06.2024 at 10:30 – 11:00.
Are you eager to strengthen our protein MS capabilities at Orion to boost our hit finding and hit characterisation activities in drug discovery?
Description Of Position
You, as a mass spectroscopy specialist in the Structural Biology and Analytics unit, will be responsible for the setting up and use of techniques like AS-MS, native MS and HDX-MS to study and understand the mode of action of proteins and modulation of protein actions by small molecules.
This is a permanent position and location of the position is in Espoo.
Description Of Unit
The unit “Structural Biology and Analytics” is a part of the Medicine Design in Innovative Medicines Business Division. Besides the analytical support for all medicinal chemistry activities, the unit focuses on hit finding activities, the understanding of protein modes of action and protein ligand interactions. On site, MS as well as NMR techniques are used to obtain the necessary information. Other techniques like cryoEM or X-ray are used via a strong external network.
We offer
The position offers an exciting and challenging opportunity for cross-scientific and -cultural collaboration and working in highly motivated teams. You will have the chance to strengthen and build up our expertise of proteins and protein ligand interactions by using & building HDX-MS, AS-MS and native MS capabilities. We have a good working atmosphere based on common values and mutual trust. Please visit our website to find further information about our values and Orion as an employer https://www.orion.fi/en/careers/orion-as-an-employer/.
Requirements
Practical skills with protein-related MS techniques, especially native MS, HDX-MS or cross-linking techniques, are mandatory to support our activities in the characterisation of protein-ligand interactions and to analyse conformational changes of proteins. The candidate’s special focus will be execution of experiments and data analysis as well as communicating the results to the project team.
The candidate needs to have a good knowledge of protein handling (production beneficial) and must be able to discuss in multidisciplinary project teams the results and the impact of the results on drug design. A basic understanding of biophysical methods is beneficial. A good network with the protein MS community around the world is a big plus.
Additional Information
Please send your application incl. salary request and CV by the 4th June 2024. We will start reviewing applications during the application period.
Approved medical examination which also includes drug testing is required prior to the employment. We will also carry out a security clearance prior to the employment for the selected person. Orion Corporation operates in more than 30 countries, where we Orionees, 3600 in total, work in all kinds of positions. Among us there are Research Scientists, Laboratory Technicians, Engineers and IT Specialists as well as people working in Production, just to mention some examples. We offer diverse and responsible jobs to our personnel in a truly multi-disciplinary work environment. We encourage people to develop their competences and offer opportunities to affect the job description and creating their own career path at Orion. We are searching for top talents who are ready to share our passion for the work that we do.
Hae viimeistään 26.6 mennessä, paikka täytetään heti sopivan henkilön löydyttyä.
About the job
Charles Riverin työntekijät ovat työskennelleet jo yli 75 vuoden ajan auttaakseen uusien lääkehoitojen löytämisessä, kehittämisessä ja turvallisessa valmistuksessa. Kun olet liittynyt perheeseemme, sinulla on mahdollisuus vaikuttaa merkittävästi ihmisten terveyteen ja hyvinvointiin eri puolilla maailmaa. Olipa taustasi biolääketieteessä, rahoituksessa, tietotekniikassa, myynnissä tai muualla, taidoilla on tärkeä rooli suorittamassamme työssä. Vastineeksi auttamme sinua rakentamaan uran, josta voit olla ylpeä.
Työn yhteenveto
Etsimme Teknikkoa Surgery/Imaging tiimiin In Vivo (IV) -yksikköömme Kuopion toimipisteeseen. Etsimme ensisijaisesti säteilytyön osaajaa. Tehtävä on määräaikainen.
Keskeisimmät toimet ja vastuut:
o In vivo -laboratorion perustoiminnot o eläinten päivittäinen hoito ja ylläpito o tutkimustekniikoiden suorittaminen koe-eläimillä keskushermostotautimalleissa (lääkinnät, käyttäytymistestit, kudosnäytteiden keräys ja käsittely) o mittausten valmistelu sekä datan kerääminen ja dokumentointi o yksikön muut tukitoimet ja avustaminen tarpeen mukaan muissa tehtävissä
Säteilytyöhön liittyvät toiminnot o Säteilytyöturvallisuus o Pipetointi ja aktiivisten aineiden käsittely o Punnitseminen o Liuosten valmistus o Radiolaboratorion ja HPLC tilojen toimintaan ja laitteisiin liittyvät ylläpitotoimet o Aktiivisen jätteen käsittely, varastointi ja hävitys o Erilaisten laitteiden käyttö (Gammacounter, annoskalibraattori, PET/CT, SPECT/CT, taustasäteilymittari/dosimetrit)
Edellytykset
o Säteilytyöluokka A o soveltuva pätevyys ammattikoulutuksen/opiskeluiden kautta hankittuna (esim. laborantti, bioanalyytikko, eläintenhoitaja, klinikkaeläientenhoitaja, koe-eläinhoitaja, luonnontieteiden opiskelija, röntgenhoitaja) o mahdollisuus työskennellä eläintiloissa o tehokas tiimityöskentely ja aktiivinen kommunikointi välttämätöntä o perustason atk-tuntemus, esimerkiksi Microsoft Office -ohjelmiston käyttö
Katsotaan eduksi:
o kokemus koe-eläintyöstä ja tutkimusteknisistä työtehtävistä (koe-eläintenhoito, lääkintä, käyttäytymisen testaaminen) o Kirurginen tai kuvantamiseen liittyvä osaaminen o HPLC osaaminen o hyvä suullinen ja kirjallinen englanninkielentaito
Tarjoamme sinulle työpaikan kansainvälisessä työympäristössä, jossa voit kehittää osaamistasi. Lakisääteisten työsuhde-etujen lisäksi käytössäsi on e-passi, 24/7 tapaturmavakuutus ja joustavat työajat. Jos olet kiinnostunut tehtävästä, lähetä hakemuksesi mahdollisimman pian. Täytämme paikan heti, kun sopiva henkilö löytyy.
Tietoa Discovery-liiketoimintayksiköstä Charles River Discovery on todistetusti ollut mukana kehittämässä uusia onnistuneita hoitomuotoja. Viimeisten 17 vuoden aikana asiakkaamme ovat saaneet yli 320 patenttia ja 74 prekliinistä lääkekandidaattia. Meillä on yli 650 tutkijaa, jotka hyödyntävät uusinta teknologiaa ja uusimpia ohjelmistoja. Näin kattava, yhtenäinen tuotevalikoimamme tarjoaa kemian, biologian ja farmakologian palveluita, jotka tukevat asiakkaitamme ensimmäisestä löydöksestä uuteen tutkimuslääkkeeseen asti. Asiakaslähtöisen, yhteistyöhön perustuvan lähestymistapamme avulla luomme todellisen kumppanuuden, jossa ennakoidaan haasteet, selvitään esteistä ja kuljetaan yhdessä koko matka tuotaessa uusia lääkkeitä markkinoille.
Tietoa Charles Riveristä Charles River on varhaisen vaiheen sopimustutkimusyritys (CRO). Toimintamme perustana on koe-eläintiede ja -lääketiede. Sille pohjalle olemme rakentaneet monipuolisen tuotevalikoiman Discovery- ja lääketurvallisuusarviointipalveluita, niin hyvän laboratoriokäytännön (GLP) mukaisia kuin sen ulkopuolisia (non-GLP), tukeaksemme asiakkaita alkaen kohteen tunnistamisesta aina prekliiniseen lääkekehitykseen asti. Charles River tarjoaa myös valikoiman tuotteita ja palveluita, joiden avulla tuemme asiakkaidemme kliinisiä laboratoriotestaustarpeita ja tuotantotoimintaa. Tätä laajaa tuote- ja palveluvalikoimaa hyödyntämällä asiakkaamme voivat luoda joustavamman lääkekehitysmallin, mikä vähentää heidän kustannuksiaan sekä parantaa tuottavuutta ja tehokkuutta ja siten nopeuttaa tuotteen pääsyä markkinoille.
Meillä on yli 22 000 työntekijää 100 laitoksessa 26 maassa ympäri maailmaa. Näin pystymme strategisesti koordinoimaan resursseja maailmanlaajuisesti ja soveltamaan monialaisia näkökulmia ratkaistessamme asiakkaidemme ainutlaatuisia haasteita. Asiakaskuntaamme kuuluu globaaleja lääkeyhtiöitä, biotekniikan yrityksiä, valtion virastoja ja sairaaloita sekä korkeakouluja ympäri maailmaa.
Me Charles Riverillä suhtaudumme intohimoisesti rooliimme ihmisten elämänlaadun parantamisessa. Missiomme, tapamme tehdä tiedettä erinomaisesti ja vahva tarkoituksen tunne opastavat meitä kaikessa, mitä teemme. Aloitamme jokaisen päivän tietäen, että työmme auttaa parantamaan monien ihmisten terveyttä ja hyvinvointia ympäri maailmaa. Vuonna 2021 olemme olleet mukana kehittämässä noin 86 %:ia FDA:n hyväksymistä lääkkeistä.
