Ajankohtaista

Research Assistant – Charles River Discovery Research Services Finland Oy – Kuopio

https://duunitori.fi/tyopaikat/tyo/research-assistant-stsyo-18164860?utm_source=loimu&utm_medium=site

About the job

Keskeisimmät toimet ja vastuut: 

– suorittaa kokeiden käytännön laboratoriotyötä 
– osallistuu eläinten päivittäiseen hoitoon ja ylläpitoon 
– suorittaa tutkimustekniikoita koe-eläimillä keskushermostotautimalleissa, kuten lääkintöjä, käyttäytymistestejä, kudosnäytteiden keräystä ja käsittelyä 
– osallistuu tutkimusten valmisteluun sekä datan keräämiseen ja dokumentointiin 
– osallistuu yksikön muihin tukitoimintoihin ja avustaa tarpeen mukaan myös muissa tehtävissä

Edellytykset

– soveltuva pätevyys ammattikoulutuksen/opiskeluiden kautta hankittuna (esim. laborantti, bioanalyytikko, eläintenhoitaja, klinikkaeläientenhoitaja, koe-eläinhoitaja, luonnontieteiden opiskelija) 
– mahdollisuus työskennellä eläintiloissa 
– tehokas tiimityöskentely ja aktiivinen kommunikointi välttämätöntä 
– perustason atk-tuntemus, esimerkiksi Microsoft Office -ohjelmiston käyttö 
– kokemus koe-eläintyöstä ja tutkimusteknisistä työtehtävistä (koe-eläintenhoito, lääkintä, käyttäytymisen testaaminen) katsotaan eduksi 
– hyvä suullinen ja kirjallinen englanninkielentaito katsotaan eduksi 

Jos olet kiinnostunut tehtävästä, lähetä hakemuksesi mahdollisimman pian.

Täytämme paikan heti, kun sopiva henkilö löytyy. 

Palkka

Aikapalkka | Time rate

Proposal Writer-Biotechnology, Biochemistry, Molecular Biology – Inspiralia, EU

https://www.linkedin.com/jobs/view/3914230154

The Company:

Inspiralia is a dynamic new product development company offering consultancy services to new businesses seeking funding. We offer solutions to our clients across a wide range of sectors such as biotechnology, energy, engineering, maritime, physics and green tech! We are passionate about innovation and providing an exceptional service to our clients. If you want to explore the depths of innovation, funding, and growth opportunities, and enjoy pushing the boundaries of what is possible keep reading below!

The Role:

We are actively seeking freelance proposal writers for the EU market. Our proposal writers are responsible for creating, developing and submitting proposals on behalf of the organization and play a vital role in securing funding for our clients. This role requires working with a multidisciplinary team and is also client facing. The scope of Proposal Writer responsibilities includes:

• Researching and gathering relevant information about the project.
• Writing and reviewing proposals for accuracy and completeness.
• Collaborating with the innovation consultants to create a winning proposal strategy.
• Consulting with subject matter experts to obtain input for technical aspects of the proposal.
• Ensuring timely submission of proposals.
• Conducting post-proposal follow-up with clients and stakeholders.

So, what will you need? All applicants must have….

• Master’s degree or PHD in Biotechnology, Biochemistry, Molecular Biology, Bioengineering.
• C1-C2 level English is a must.
• Some experience writing grant proposals for European commission programs as a plus!
• Some experience with EIC Pathfinder, RIA, IA, EIC Transitions programs. EIC Accelerator experience is desirable.

Please note all our proposals require a high level of technical expertise so if you don’t have the technical background in the areas listed above, we will not be able to progress your application!

Nice to have:

• Previous experience working in an international environment.
• Experience drafting business models/ market reviews.
• Experience in client facing role.

Skills:

• Organized and methodical approach to projects.
• Must have the ability to condense key ideas and communicate them effectively.
• Self-motivated and goal-orientated with the ability to work independently and as part of a team.
• Understand clients’ business needs, challenges, and goals.
• Able to deliver under pressure and meet deadlines.
• Commercial mindset, comfortable speaking to key players.
• Imaginative, creative, and curious
• Unafraid to innovate.

What can you expect from Inspiralia?

· Competitive pay.

· Generous success bonus.

· Work with expert teams and receive training.

· Write for a variety of ground-breaking projects.

Sound good? Please send us your CV.

Inspiralia is an equal opportunity employer and does not condone discrimination on the bases of race, religion, colour, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, family medical history or genetic information, political affiliation, military service, or other non-merit-based factors. All applicants will be considered.

Solution Scientist, Velsera, Remote

https://www.linkedin.com/jobs/view/3909960881

Employment type: Full time

About the job

Welcome to the era of Velsera! Seven Bridges, Pierian & UgenTec have combined to become Velsera.

Velsera is the precision engine company. We empower researchers, scientists, and clinicians to drive precision R&D, expand access to, and more effectively leverage analytics at the point of care.

We unify technology-enabled solutions and scientific expertise to enable a continuous flow of knowledge across the global healthcare ecosystem. This interweaves diverse biomedical communities, allowing them to build upon each other’s success and accelerate medical breakthroughs that positively impact human health.

With our headquarters in Boston, MA, we are growing and expanding our team which located in 14 different countries!

The Solution Scientist Team at Velsera brings together diverse team members individuals who possess a unique balance of technical/scientific expertise and strong interpersonal skills. We are looking for individuals who demonstrate the ability to think strategically about research and business questions, understand the scientific problems that clients need to solve and develop strategies for maximizing the success of a solution. We are passionate about helping our clients achieve success.

The Solution Scientist will play an important role in advancing Velsera’s mission to improve human health globally through multi-omics and insights, leveraging your scientific background to help enable research innovation across large organizations. As a Solution Scientist you will work closely with our clients at some of the world’s largest biotechnology and pharmaceutical companies to enable them to leverage Velsera products and services to speed up the development of novel therapeutics. In this role, you will meet with clients frequently and serve as their scientific partner. You will become an expert user of the Velsera products and scientifically engage our clients to gain the most value from our platform and consultative services. You will talk to clients to understand their needs, capture feedback about our product(s) and serve as an internal expert on client needs. Your frequent client interactions will make you a valuable resource for our product development and marketing teams to be able to better understand and support the objectives of our clients.

You love working in a team and can also accomplish tasks independently. You are people-oriented and an excellent communicator. You can understand user perspectives, and are enthusiastic to partner with our clients to enable them to achieve research and business goals. You bring strong relationship-building experience, scientific knowledge, as well as a high degree of empathy to ensure the client’s satisfaction with Velsera products and services.

What will you do? 

• Serve as brand ambassador of Velsera, responsible for providing a collaborative and problem-solving environment to our prospective and/or existing clients. In your actions and engagements, you will share and represent the company’s scientific mission and vision for success. 
• Become a scientific partner within the client’s organization and develop a trusted working relationship, ensuring the prospective and/or existing client’s success in adopting and leveraging Velsera products and services. 
• When assigned, maintain and track relationships with existing clients and become the internal authority on their technical bottlenecks, scientific needs, and future plans. Ultimately, with experience, you will be able to predict your client’s reaction and responsiveness to new features and present solutions that will resonate with their specific research and business needs.
• Identify strategies to support our prospective and/or existing clients via projects and initiatives, facilitating a comprehensive understanding of the client’s requirements to maximize success of all work. 
• Expand prospective and/or customer product knowledge and enable ease of Velsera products by delivering demos and/or onboarding training with periodic customized educational sessions tailored to their specific scientific use-case.
• Differentiate between what the prospective and/or existing client wants vs. what they actually need in order to resolve the problem at hand. You will understand the broader canvas of their needs and bring this feedback to our product teams, advocating strongly for market-driven changes to our roadmap.
• Partner with sales team members to help win deals by developing and delivering value based technical/scientific demonstrations highlighting our powerful Velsera platform ecosystem, capabilities, and the Art of the Possible
• Attend and support Velsera booths at conferences and industry events. 

What do you bring to the table? 

• PhD or relevant research experience in genetics, bioinformatics, computational biology, data science or a related discipline required 
• 1-3 years of experience 
• Experience working in a customer-facing role preferred 
• Passion for advancing science quickly and sharing knowledge, both internally within Velsera and externally with prospective organizations 
• Have a self-motivated and results-oriented approach with a flexible, ”can-do” attitude 
• Excellent written and verbal communication skills 
• Possess exceptional communication skills, with a proven ability to deliver effective and compelling presentations to both domain and non-domain experts 
• Be able to effectively coordinate and multitask cross-functionally and be a supportive, team player 
• Possess strong relationship building skills, as well as a high degree of empathy 
• Ability to work within a virtual global team environment 
• Knowledge in genomics, bioinformatics, epidemiology, multi-omics, and/or biomedical data analysis preferred 
• Experience with large-scale genomic data management (cloud computing) and/or analysis preferred 
• Experience in cloud-based environments through hands-on data analysis or management preferred 
• Knowledge of the applications of big data, such as genomics, in cancer and other therapeutic areas and understanding of the challenges clinicians and researchers face when integrating data, (i.e. genomics) into research/clinical workflows 
• Flexibility to travel to client sites and conferences on a limited basis 
  

Our Core Values

People first. We create collaborative and supportive environments by operating with respect and flexibility to promote mental, emotional and physical health. We practice empathy by treating others the way they want to be treated and assuming positive intent. We are proud of our inclusive diverse team and humble ourselves to learn about and build our connectionwith each other.

Patient focused. We act with swift determination without sacrificing our expectations of quality. We are driven by providing exceptional solutions for our customers to positively impact patient lives. Considering what is at stake, we challenge ourselves to develop the best solution, not just the easy one.

Integrity. We hold ourselves accountable and strive for transparent communication to build trust amongst ourselves and our customers. We take ownership of our results as we know what we do matters and collectively we will change the healthcare industry. We are thoughtful and intentional with every customer interaction understanding the overall impact on human health.

Curious. We ask questions and actively listen in order to learn and continuously improve. We embrace change and the opportunities it presents to make each other better. We strive to be on the cutting edge of science and technology innovation by encouraging creativity.

Impactful. We take our social responsibility with the seriousness it deserves and hold ourselves to a high standard. We improve our sustainability by encouraging discussion and taking action as it relates to our natural, social and economic resource footprint. We are devoted to our humanitarian mission and look for new ways to make the world a better place.

Velsera is an Equal Opportunity Employer:

Velsera is proud to be an equal opportunity employer committed to providing employment opportunity regardless of sex, race, creed, colour, gender, religion, marital status, domestic partner status, age, national origin or ancestry.

Doctoral Researcher – University of Helsinki

Research Assistant, Antibody-Drug Conjugates Team, Oncology Research, Turku

Job description

https://duunitori.fi/tyopaikat/tyo/orion-research-assistant-antibody-drug-conjugates-team-oncology-research-turku-turku-sdsuu-18183307

The Antibody-Drug Conjugates (ADCs) Team is seeking a highly motivated and skilled Research Assistant to work in the R&D laboratories in Turku. This is a hands-on position for an experienced Assistant who enjoys working in the lab. You will have an opportunity to be part of a dynamic, highly motivated, and international team and work in modern laboratory facilities equipped with state-of-the-art laboratory instrumentation.

Main responsibilities 

• Provide research support for in vitro cell-based assays, biochemical assays, and molecular biology analysis such as FACS, IF staining & cell imaging, WB, and qPCR.  
• Independently maintain and perform studies with mammalian cell cultures. 
• Determine the potency of antibody-drug conjugates and free payloads.
• Determine antibody binding, protein surface density, and antibody internalization in vitro.
• Be responsible for the accurate documentation of research and screening results.
• Maintain high housekeeping standards and take responsibility for routine laboratory and cell culture maintenance tasks.

You will be based in Turku, Finland, and report to the Head of the Antibody-Drug Conjugates Team. This is a permanent position. 

Description of unit

Oncology Research is accountable for discovering novel targets and research projects in the therapy area of oncology at Orion. 

ADCs Team is one of three scientific units in Oncology Research, a part of Orion’s RnD Organization. The ADCs Team is focused on discovering therapeutic targets and the active development of ADCs by utilizing a broad panel of biophysical, biochemical, cellular, and in vivo methods. We aim to develop cutting-edge ADC therapies that can transform cancer patients’ lives.

We offer

Join our dynamic and experienced team of in vitro and in vivo scientists and assistants as we pioneer Oncology Research at Orion. With an exciting R&D pipeline and a supportive working environment, you’ll have the chance to leverage your strengths to grow both professionally and personally. Experience a culture of appreciation, continuous development, and mutual trust. Please visit our website to find further information about our values and Orion as an employer https://www.orion.fi/en/careers/orion-as-an-employer/.

Get to know Orion’s research assistants featured in this article https://www.orion.fi/en/newsroom/all-news/articles/we-are-orion/orion-research-assistants-work-to-defeat-cancer-and-relieve-pain-our-discovery-could-change-the-course-of-research/ and join our team of well-being professionals!

Requirements

A successful applicant has several years of experience in hands-on laboratory work and techniques related to cellular and biochemical assays, and standard molecular biology techniques (FACS, WB, qPCR, IF). Strong knowledge and experience working with mammalian cell cultures and related functional studies (e.g. proliferation) are required. Additionally, we expect that you have a suitable degree in the field of health sciences, for example, from the University of Applied Sciences.

You are highly motivated and possess interpersonal and organizational skills that allow you to interact in a collaborative work environment. You also have basic computational skills, ideally experience in documentation using an electronic lab notebook, and can communicate in verbal and written English. Industry experience is an advantage but not a requirement.

Additional information

Interested candidates are invited to submit their resume and cover letter detailing their relevant experience. Applications will be accepted until the 31st of May 2024. Shortlisted candidates will be contacted for an interview to further discuss their qualifications and potential fit within our team.

For additional details, don’t hesitate to contact Marcin Chrusciel, Head of the Antibody Drug Conjugates Team, at tel. +358 509667861 at any of the following times (Finnish Time): 16th of May 15:00-16:00 and 22nd of May 15:00-16:00.

Approved medical examination which also includes drug testing is required prior to the employment. We will also carry out a security clearance prior to the employment for the selected person.

Doctoral researcher – Clinical chemistry research group, Tampere University

https://duunitori.fi/tyopaikat/tyo/doctoral-researcher-sdsuu-18146320

Doctoral Researcher (Medical Bioinformatics)

The Clinical Chemistry lab, at the Faculty of Medicine and Health Technology (MET) in Tampere University is seeking a Doctoral Researcher to study bioinformatic approaches for integrative analysis of omics and clinical data aimed at identifying molecular signatures of cardiovascular and related diseases. The position will be full-time and filled for a fixed-term period of 12 months initially with possible extension. The workplace is located at Kauppi Campus, Tampere University.
The project will be a part of an ongoing EU project, CVDLINK aimed at utilization of real-world data sources for the enhancement of diagnosis, prognosis and risk assessment of cardiovascular conditions. During the course of the project, the student will have a wide range of opportunities to participate in international projects, contributing in bioinformatics/statsitical analysis, to build expertise in the field of medical bioinformatics.

Job description

Your task will be to develop and implement bioinformatic methods for analysis of multi-omics and clinical data in a large cohort, in integrative manner, aimed at identifying novel molecular signatures of cardiovascular and related diseases. You will be working in supportive and flexible work environment under the supervision of post-doctoral researchers with extensive expertise in Bioinformatics. The selected candidate will be able to focus on their doctoral research full-time, get supervision, and implement new ideas as a part of a research team in the positive and multidisciplinary environment of the MET faculty. The selected candidate must, later on, be accepted into a doctoral program of our Faculty. Please visit the admissions page for more information on eligibility requirements.

Requirements:
• Master’s degree in bioinformatics or closely related field.
• Methodological and theoretical skills in statistics and proficiency R programming
• Strong experience or interest in big data, preferable, omics data analysis.
• Fluency in English

We offer

The doctoral researcher position will be filled from 1.6.2024. The position is a fixed-term period of 12 months initially with possible extension. A trial period of 6 months applies to all our new employees.

The salary will be based on both the job demands and the employee’s personal performance in accordance with the University Salary System. According to the criteria applied to teaching and research staff, the position of a Doctoral researcher is placed on the job demands levels 2-4. A typical starting salary for a Doctoral Researcher is approximately 2600 € per month. The salary increases are based on the progression of doctoral research and studies.
We offer a wide range of staff benefits, such as occupational health care services, flexible working hours and versatile research infrastructure.

How to apply

Please email pashupati.mishra (at) tuni.fi with following attachments:
• CV
• Motivational letter that briefly outlines motivation to apply, background and skills related to positions, tentative research questions/ideas, and any other miscellaneous remarks that the candidate wishes to make.
• PDF copy of your Master’s degree certificate, including transcripts in original language. If original language is other than Finnish, Swedish or English, please provide an official translation in one of those languages.
• Contact information of one or two referee(s).

For more information
Should you have any questions about the project or the working environment, don’t hesitate to contact directly:
Pashupati Mishra, pashupati.mishra (at) tuni.fi

Freelance CRA – Medical Devices – Finland

https://www.linkedin.com/jobs/view/3879690286

RBW Consulting are delighted to be partnered with one of the worlds leading organisations that focus solely on Medical Device studies to support them on a Cardiovascular device study in Finland kicking off in May/June time. RBW have worked with this organisation for over a year now and the feedback from multiple contractors we have placed there has been that this one of the best companies to work for in the industry as a contractor as you feel valued just as much as the permanent staff.

You:

• Previous Medical Device monitoring experience is essential
• Cardiovascular/Cardiology study monitoring is desired, ideally within the device field
• Up to date knowledge of MDR

The contract:

• 0.3 FTE
• €100-115 p/h DOE
• 5 year study

Please apply here and Harry Henson will be in touch to discuss your application further!

Doctoral Researcher in RNA-based mechanisms – University of Helsinki

https://www.linkedin.com/jobs/view/3914283022

The RNAcious laboratory at the Faculty of Biological and Environmental Sciences, University of Helsinki, is recruiting a doctoral researcher to study how pathogens utilize RNA-based mechanisms to further infection in prokaryotic model organisms.

The RNAcious laboratory , led by Dr Peter Sarin, is at the forefront of exploring RNA-based mechanisms that modulate protein synthesis in response to abiotic and biotic stresses. We utilize state-of-the-art LC-MS and RNA-seq techniques to address significant questions in tRNA biology, for example how post-transcriptional tRNA modification dynamics influences host and pathogen translation during infection, how adaptation of tRNA modification affects neoplastic proliferation, and how tRNA modifications may be utilized to tune translation.

We are looking for a skilled doctoral researcher (PhD student) that will work in a vibrant and international research environment as part of a Research Council of Finland funded project on RNA-mediated pathogenicity mechanisms in prokaryotic models. The successful applicant will work on one of two focus areas: (i) characterizing the role and dynamics of viral RNA-based components during virus infection, or (ii) exploring virus infection-mediated changes in archaeal translation. The project entails collaborative aspects with other teams and universities and will be tailored together with the successful applicant based on their interest and prior experience.

Qualifications

Eligible applicants are required to have an applicable second-cycle university degree, an applicable second-cycle degree from a university of applied sciences, or an applicable education at an institution abroad providing eligibility for equivalent higher education in the country in question. The degree must be in a relevant field of research, such as molecular biology, microbiology and/or virology, biochemistry, genetics, or biotechnology, or provide equivalent skills and knowledge.

Prior experience in microbial characterization, translation studies, RNA-seq, and/or applicable bioinformatics is considered an advantage. Furthermore, successful applicants are expected to be competitive in national and international funding schemes. Good communication skills in English (oral and written) are essential, as are enthusiasm for the topic, strong motivation to learn and adapt new skillsets, and readiness to work with diverse teams.

Position details

A successful candidate will be employed initially on a full time, two-year fixed-term contract starting in September 2024 (or at a later date, by agreement). Upon positive evaluation, the contract may be extended to a total of four years (from the original start date of the position). A six-month trial period applies.

The appointee is expected to apply for the right to pursue a doctoral degree at the University of Helsinki. The application periods for doctoral education at the University of Helsinki are in February and September. For more information on degree requirements and the application process, please visit https://www.helsinki.fi/en/research/doctoral-school .

The salary is based on level 2 of the job requirement scheme for teaching and research personnel in the salary system of Finnish universities. In addition, the appointee will be paid a salary component based on personal work performance, which is usually set at 10-18% at the onset of employment. The University of Helsinki offers comprehensive services to its employees, including occupational health care and health insurance, sports facilities, and opportunities for professional development. The doctoral researcher will also benefit from courses, funding opportunities, and training offered by the University of Helsinki Doctoral School.

Applications for the position should include:

• A concise cover/motivation letter (no longer than one A4 page).
• A curriculum vitae, structured as per TENK guidelines (applicable sections, see https://tenk.fi/en/advice-and-materials/template-researchers-curriculum-vitae ), including two references.
• Research statement (max. two A4 pages) consisting of
  

I) a Brief Description Of Previous Research Experience,

ii) outline of research skills, and

iii) how these skills support one of the two focus areas.

• Copy of M.Sc. diploma (or equivalent) and a transcript of completed credits.

The requested documents must be compiled in the above-specified order into a single PDF document. Note that compliance to given instructions constitutes a selection criterion.

Contact information

For more information on the position, please contact Dr Peter Sarin by email ( peter.sarin@helsinki.fi ).

Please submit your application using the University of Helsinki Recruitment System via the Apply now link.

The application deadline is May 31st, 2024.

Staff Scientist in Microscale Biomechanics, Aalto University

https://www.linkedin.com/jobs/view/3913534383

Department of Electrical Engineering and Automation at the Aalto University School of Electrical Engineering is looking for a Staff Scientist in the field of Microscale Biomechanics, including biomechanical measurements in 3D cultures, mechanical effects on cell differentiation and migration as well as remodeling of the extra cellular matrix.

Staff Scientist in Microscale Biomechanics

Are you motivated to work with ambitious research groups and innovative projects in Microscale Biomechanics? We offer you a unique opportunity to work on interdisciplinary, cutting-edge research projects with close collaboration with partners at Aalto, in Finland, and internationally, as well as close interaction with Ph.D. students, research staff, and industry experts.

Research environment

Department of Electrical Engineering and Automation houses several research groups studying various aspects of health-related technologies and nanomaterials. The staff scientist to be recruited will focus on microscale biomechanics, area that is located between living and man-made materials. The position will be placed in the Microsystems Technologies group led by prof. Tomi Laurila.

Your role and goals

The staff scientist position is for an academic staff member who is a specialist in research work connected to the microscale biomechanics.

The primary responsibilities of the staff scientist will include:

• Performing demanding research in microscale biomechanics
• Managing and planning research equipment and infrastructure related to microscale biomechanics, such as cell culturing facilities
• Preparation and management of research projects
• Supervision of research, including M.Sc. and doctoral theses
  

The expected distribution of work among various duties is 50% research, 20% teaching, and 30% service.

Your Experience And Ambitions

We seek candidates that:

• have a doctoral degree in a relevant field
• have demonstrated evidence of successful research work shown by a strong scientific publication record
• have research experience in microscale biomechanics, cell material interactions and related topics.
• are motivated in networking and research collaboration with other research groups, nationally and internationally
  

Additional merits that are considered include:

• Previous experience with similar equipment used by the research group
• International experience especially in US and Europe
• Experience in project management or other duties at the group/department/university level
• A track record of acquiring competitive funding
  

Salary and contract terms

The Staff Scientist position will be filled permanently. The starting salary will be set according to department guidelines depending on experience and qualifications. The contract includes occupational health care and social security benefits. The planned starting date is in August 2024 but can be negotiated.

Ready to apply?

Please submit your application through our recruiting system by using the ”Apply now!” link below. Include the following documents in English in a single PDF file: 1) a motivation letter, 2) a CV indicating your skills and experience applicable to the position, including your teaching experience, 3) a list of publications (with the 5 most significant publications highlighted), 4) research statement, and 5) references (names and contact information). The application period closes on May 29, 2024.

More information

For additional information, please contact Professor Jorma Kyyrä (jorma.kyyra@aalto.fi) and in application practicalities HR partner Camilla Hanganpää (camilla.hanganpaa@aalto.fi).

Aalto University is where science and art meet technology and business. We shape a sustainable future by making research breakthroughs in and across our disciplines, sparking the game changers of tomorrow and creating novel solutions to major global challenges. Our community is made up of 13 000 students, 400 professors and close to 4 500 other faculty and staff working on our dynamic campus in Espoo, Greater Helsinki, Finland. Diversity is part of who we are, and we actively work to ensure our community’s diversity and inclusiveness. This is why we warmly encourage qualified candidates from all backgrounds to join our community.

Postdoctoral Researcher in Computational Genomics and Machine Learning, University of Helsinki

https://www.linkedin.com/jobs/view/3908509447

Postdoctoral Researcher in Computational Genomics and Machine Learning through the NORPOD program

NORPOD is a collaborative postdoctoral program of the Nordic EMBL Partnership for Molecular Medicine. The partnership is a network of four national research centers across the Nordics and the European Molecular Biology Laboratory (EMBL) , with complementary research expertise at the forefront of molecular medicine research. With the NORPOD program, the Nordic EMBL Partnership aims to foster the next generation of researchers in molecular medicine by implementing joint postdoctoral research projects to nurture strong competences and research excellence.

FIMM is currently seeking a Postdoctoral Researcher to join the Machine Learning in Biomedicine group, in collaboration with the Precision Cancer Epigenomics group at NCMM, through the NORPOD program.

Summary Of The Project

Human tumors are characterized by recurrent mutations in the well-defined cancer driver genes, but also non-mutational epigenetic reprogramming and phenotypic plasticity controlled by transcription factors (TF) are important contributors to tumorigenesis. Extensive consortium efforts have mapped the mutational and epigenetic landscapes of human cancers. However, the commonly used epigenomics methods such as ChIP-seq are correlative in nature and report a lot of spurious sites that might not be linked to gene expression, highlighting the need for novel innovative approaches to understand cancer genome and epigenome. Here, we will utilize cutting-edge long-read nanopore sequencing combined with deep machine learning approaches to model the epigenetic changes and mutational mechanisms in cancers originating from endodermal tissues. The goal is to reveal novel mechanistic details about the development of human cancer.

Tasks

The postdoctoral researcher will analyze NaNOME-seq, ATAC-seq and RNA-seq data to model the gene regulatory logic in epithelial cells. In addition, the researcher will investigate the effects of DNA adducts on methylome, transcriptome, and the gene regulatory logic.

Skills, Expertise And/or Qualifications

We expect a successful candidate to have a PhD degree from a relevant field with skills and experience in computational genomics and machine learning. Familiarity with the above-mentioned data types is an asset, as well as a strong publication record in a relevant field. Good written and oral communication skills in English are expected.

Research Group Descriptions

The Machine Learning in Biomedicine group led by Dr. Esa Pitkänen at FIMM develops novel machine learning methods and models to answer key questions in biomedicine: how do mutations arise and contribute to disease? How to accurately predict cancer patient outcomes? What is the role of inherited genetic factors in diseases? Together with our collaborators, we focus on answering these questions in cancers and hematological malignancies. We create scalable and multimodal machine learning techniques utilizing genome, transcriptome, epigenome and imaging data to build clinically useful computational tools.

The Precision Cancer Epigenomics group led by Dr. Biswajyoti Sahu at NCMM investigates the role of transcription factors in human diseases using modern genome-wide approaches for regulatory genomic features and chromatin architecture. We employ various model systems such as mammalian cell lines, 3D organoid cultures and stem cell-based methods as well as cutting-edge genome-wide approaches from ChIP-seq, CUT&RUN and HiChIP to single-nuclei multiome RNA-seq and ATAC-seq assays, epigenetics analysis using Illumina and single-molecule nanopore sequencing, and CRISPR-based approaches for genome editing. Our goal is to provide mechanistic understanding of the role of transcription factors and enhancer malfunction in development of enhanceropathies such as cancer.

Implementation

The NORPOD Fellow will be employed at the Machine Learning in Biomedicine group (FIMM, University of Helsinki, Finland). To promote collaboration between the two groups, this position will involve regular visits to and communication with the Precision Cancer Epigenomics lab (NCMM, University of Oslo, Norway). Successful candidates are expected to travel between the labs to conduct work required for the research project, foster synergies and advance our goals. Expenses related to the research visits will be covered.

Contract & salary

The job is for a fixed term of 2.5 years. A trial period of 6 months will be applied. Salary will depend upon the applicant’s level of skills, knowledge, and abilities and is based on the university salary system. The starting salary will be ca. 3,500 – 3,800 euros/month, depending on the appointee’s qualifications and experience and including a salary component based on personal performance. Standard Finnish pension benefits and occupational health care are provided for University employees. We welcome applicants from a variety of gender identities, linguistic and cultural backgrounds.

Selection process

• The collaborating PIs of the research project will shortlist and video interview the top candidates.
• Top candidates will be invited for an online interview, conducted by an independent selection panel where they will also be given the opportunity to pitch the project plan.
• NORPOD Fellowships will be awarded based on the recommendation of the selection panel.
  
  

How to apply:

The application should include (i) CV with a complete list of scientific publications, (II) a one-page statement of motivation for applying for this position, (iii) contact information of at least two reference persons who have agreed to provide a written statement on behalf of the applicant.

To apply, please submit the application through the University of Helsinki electronic recruitment system by clicking on Apply for job. Internal applicants (i.e., current employees of the University of Helsinki) please submit your applications through SAP Fiori https://msap.sap.helsinki.fi.

Please apply no later than 31st of May 2024

The University of Helsinki is an international scientific community of 40,000 students and researchers. It is one of the leading multidisciplinary research universities and ranks among the top 100 international universities in the world.

The Institute for Molecular Medicine Finland (FIMM) is an international research unit focusing on human genomics and personalised medicine at the Helsinki Institute of Life Science (HiLIFE) of the University of Helsinki – a leading Nordic university with a strong commitment to life science research. As part of Academic Medical Center Helsinki in Meilahti campus FIMM collaborates locally with the Faculty of Medicine, Helsinki University Hospital and National Institute for Health and Welfare. FIMM is part of the Nordic EMBL Partnership for Molecular Medicine, composed of the European Molecular Biology Laboratory (EMBL) and the centres for molecular medicine in Norway, Sweden and Denmark, and the EU-LIFE Community.