Ajankohtaista

Welcome to The Finnish Society for Cell Biology’s 50th Anniversary Celebrations!

23.1.2024 | Ajankohtaista

We are delighted to invite you to the celebration of our society’s 50th anniversary on 15th of March 2024 in Jyväskylä, Ambiotica, Survontie 9c! This special day will be filled with exploring cutting-edge science and timely topics with your colleagues from across Finland, and a delightful anniversary dinner with live music. 

Date: Friday 15th of March
Time: Society annual meeting 12:00pm
          Anniversary seminar: 2:00pm – 6:00pm
          Anniversary dinner: 6:00pm

Venue: Ambiotica Lecture Hall YAA303, Ylistönrinne
            Survontie 9c, 40500 Jyväskylä

Anniversary seminar theme: Towards smarter care and health innovations using cell biology 

Seminar sessions
1. Challenges of health communication
Speakers: Tuomas Aivelo (University of Helsinki), Pauli Ohukainen (Tervettä Skeptisyyttä Oy, Oura Health)
2. Artificial intelligence in cell biology research and healthcare
Speakers: Leena Latonen (University of Eastern Finland), Lassi Paavolainen (Institute for Molecular Medicine Finland), Juha Väyrynen (University of Oulu)
3. Young scientists as future pioneers in cell biology 
Speakers: Sonja Koivukoski (University of Eastern Finland), Veera Luukkonen (Åbo Akademi)

Anniversary dinner:
Start time: 6:00pm
Venue: Ravintola Ylistö, YFL-building, Survontie 9c, 40500 Jyväskylä
Dress code: Smart casual
Dinner price: 25€, 15€ for students and society members 

Dinner menu:
Starter: Mixed green salad with pomegranate and lemon vinaigrette 
             Seasonal kale with herbs and pine nuts
             Ricotta ravioli with cherry tomatoes and spinach
             Spelt and beetroot salad
             Smoked vendace and potato salad 

Main course: Slow-cooked beef cheek with blackcurrant-infused red wine sauce
                    Roasted garlic-rosemary tomatoes and vegetables

Dessert: Raspberry-white chocolate cake 

Please specify any allergies or food restrictions when registering! 

Registration deadline: 1st of March 2024. Register here: https://link.webropolsurveys.com/S/9FF983E7D17EAC49

More detailed information on the seminar program: 

We can’t wait to welcome you to Jyväskylä!

Osallistu Suomen Solubiologit ry:n haalarimerkkikilpailuun! Join The Finnish Society for Cell Biology Patch Design contest!

21.1.2024 | Ajankohtaista

Osallistu Suomen Solubiologit ry:n haalarimerkkikilpailuun!

Suomen Solubiologit ry juhlii tänä vuonna 50-vuotista taivaltaan, ja haluamme juhlistaa merkittävää vuosipäivää uuden, upean haalarimerkin avulla! Vanhat haalarimerkkimme ovat loppuneet, joten etsimme nyt luovia jäseniämme ja seuraajiamme suunnittelemaan seuraavaa merkkiä yhdistyksellemme.

Kilpailuohjeet:

Suunnittele haalarimerkki, joka kuvastaa Suomen Solubiologit ry:tä, ja mahdollisesti sen 50-vuotista taivalta.

Lähetä suunnittelemasi haalarimerkkikuva sähköpostitse osoitteeseen suomensolubiologit@gmail.com viimeistään 29.2.2024 mennessä.

Palkinnot:

Voittaja saa vuoden ilmaisen jäsenyyden ja oman suunnittelemansa haalarimerkin.

Vaihtoehtoisesti voittaja voi valita ilmaisen illallisen yhdistyksemme 50-vuotisjuhlatapahtumassa Jyväskylässä 15.3.2024.

Osallistu nyt ja ota osaa juhlavuoteemme!

**

Join The Finnish Society for Cell Biology Patch Design contest!

The Finnish Society for Cell Biology celebrates its 50th anniversary this year, and we want to commemorate this milestone with a brand new patch! Our old patches are out of stock, so we’re calling our creative members and followers to design a new patch for our society.

Contest guidelines:

Design a patch that represents The Finnish Society for Cell Biology, and perhaps its 50 years of history.

Submit your patch design via email to suomensolubiologit@gmail.com by 29.2.2024.

Prizes:

The winner will receive a year of free membership and their designed patch.

Alternatively, the winner can choose a complimentary dinner at our 50th-anniversary celebration in Jyväskylä on March 15, 2024.

Submit your design and join the celebration!

Research Assistant, 6-16 positions (CoEBoC) / Tutkimusapulainen 6-16 tehtävää (CoEBoC) – Tampere University, Tampereen yliopisto

11.1.2024 | Ajankohtaista

https://tuni.rekrytointi.com/paikat/?o=A_RJ&jgid=3&jid=2165

Tampere University and Tampere University of Applied Sciences create a unique environment for multidisciplinary, inspirational and high-impact research and education. Our universities community has its competitive edges in technology, health and society. www.tuni.fi/en

The Centre of Excellence in Body-on-Chip Research (CoEBoC) is a multidisciplinary research consortium combining cell biology and engineering and aims at developing body-on-chips to model human tissue function.  The center has multidisciplinary expertise on human stem cells, biomaterials, sensors, microfluidics, biomodeling and bioimaging. CoEBoC produces new comprehensive knowledge on understanding tissue interactions, constructing complex in vitro tissue co-cultures and controlling their functionalities. The resulting expertise and technologies will improve for example development of disease modeling, new personalized treatments and drug development.

Job description

We are looking for 6-16 Research Assistants to work on research and development projects within multidisciplinary research consortium. The open positions are related to ongoing research projects of CoEBoC concentrating on stem cells, cell differentiation, molecular biology, 3D culturing, biomaterials, sensors technology, microfluidics, microfluidic chips, biomodeling or bioimaging.  

Requirements

Candidates of all higher education levels with more than one year of studies are welcome to apply. The position requires basic knowledge of the CoEBoC’s research areas and good English communication skills.

Tampere University is a unique, multidisciplinary, and boldly forward-looking community. Our values are openness, diversity, responsibility, courage, critical thinking, and learner-centeredness. We hope that you can embrace these values and promote them in your work.

We offer

The position will be full-time/part-time and it will be filled for a fixed-term period of three months starting preferably in May-June 2024.  A trial period applies to all our new employees.

The salary will be based on both the job demands and the employee’s performance following the University Salary System. The position of Research Assistant is placed on the job demand level 1 (the demand level chart for the teaching and research staff). In addition, employees will receive a performance-based salary which for Research Assistants is based on their study credits.

We offer a wide range of staff benefits, such as occupational health care, flexible working hours, excellent sports facilities on campus and several restaurants and cafés on campus with staff discounts. Please read more about working at Tampere University.

We are inviting you to be a part of a vibrant, active and truly international research community. Interdisciplinarity is highly encouraged, as it allows you to expand your research network and exposes you to new perspectives and ideas to solve complex research problems and pursue novel research findings. We have a strong commitment to the highest level of scientific research and the provision of high-quality doctoral education.

How to apply

Please submit your application through our online recruitment system (link below). Please note that you will need to choose your preferred research groups (1-3) in the online application. The closing date for applications is January 31st, 2024 (at 23:59 EET / UTC +2). Applications and all accompanying documentation should be written in English, and attached in PDF format. Please note that applicants may be invited to participate in an interview throughout the application time and therefore we encourage you to apply as soon as possible. We are aiming to make the decisions by March 15th, 2024.

Applications should include the following documents:

  • Curriculum Vitae
  • Transcript of studies
  • Motivation letter that includes your preferred choices (1-3) for the research group:
    • Adult Stem Cell Group
    • Biomaterials and Tissue Engineering Group
    • Computational Biophysics and Imaging Group
    • Heart Group
    • Micro- and Nanosystems Group
    • Neuro Group
  •  A copy of the possible bachelor’s degree

For more information, please contact: coordinator, Miina Björninen, email: miina.bjorninen@tuni.fi.

***

Tampereen yliopisto ja Tampereen ammattikorkeakoulu muodostavat yhdessä Suomen toiseksi suurimman monitieteisen, innostavan ja vaikuttavan tutkimus- ja oppimisyhteisön. Korkeakouluyhteisömme osaamiskärjet ovat tekniikka, terveys ja yhteiskunta. Lue lisää: www.tuni.fi

Monikudosmallintamisen huippuyksikkö (CoEBoc) hakee 6-16 tutkimusapulaista.

Monikudosmallintamisen huippuyksikkö on kuuden Tampereen yliopistossa toimivan tutkimusryhmän muodostama poikkitieteellinen tutkimuskeskus. Huippuyksikkömme tavoitteena on yhdistää teknologisten ja biologisten tieteiden osaamista uudenlaisen body-on-chip -konseptin kehittämiseksi. Body-on-chipillä tarkoitetaan soluviljelylaitteistoa, jossa itse soluviljelmien lisäksi on tekniikkaa solujen stimuloimiseksi sekä toiminnan monitoroimiseksi. Laitteisto on yleensä rakennettu mikrofluidististen alustan päälle, joka mahdollistaa automatisoidun soluviljelynesteen kierrättämisen sekä mahdollisen lääkeainesyötön. Huippuyksikkömme tavoitteena on rakentaa ihmiskehon toimintoja jäljittelevä monikudosmalli ihmisen kudosten perusbiologian tutkimiseen sekä systeemisten sairauksien että traumojen mallintamiseen.

Tehtävänkuvaus

Tutkimusapulaisen tehtävät muodostuvat erilaisista monikudosmallintamiseen liittyvistä laboratoriotyötehtävistä. 

Hakuohjeet

Lue tarkemmat tiedot tehtävästä ja hakuohjeet yllä olevasta englanninkielisestä ilmoituksesta.

Jätäthän hakemuksesi yliopiston sähköisellä hakulomakkeella (linkki löytyy tämän ilmoituksen alta). Hakuaika tehtävään päättyy 31.1.2024 klo 23.59. Haethan tehtävään mahdollisimman pian, sillä hakemuksia käsitellään ja haastattelukutsuja lähetetään mahdollisesti jo hakuaikana.

PhD student, Lipids platform – VTT, Espoo

7.1.2024 | Ajankohtaista

https://www.linkedin.com/jobs/view/3791986598

About the job

Are you interested in development of biobased surfactants and looking for a new job opportunity in the field? Would you like to do impactful research in the cutting edge of natural sciences with superb colleagues who are top experts in their field? Do you want to build a science career and work in a versatile role at the interface of academy and industry? VTT might be just the place for you.

VTT is one of the leading applied research organisations in Europe. What unites us are curiosity, a passion for learning, and a purpose: to solve the biggest challenges of our time and turn them into sustainable growth and well-being. Our cross-disciplinary community of over 2000 brilliant minds focuses on creating impact through science-based innovation. In recent years, we have created ground-breaking innovations such as the world’s fastest and most accurate radiation detector, a cancer-sniffing sensor device for smartphones, and a headphone set entirely made of microbial materials. Get to know us further by exploring VTT’s tech & infra .

We are now looking for a PhD student to join our Production host engineering team.

As a PhD student, you have an opportunity to focus on research towards PhD degree under the supervision of experienced professionals and to develop our lipid platform, which serves as a core technology for multiple industries from food to pharma and fuel. The main fields of research include yeast physiology, metabolic engineering, genetic engineering and synthetic biology. In this position, you will have the opportunity to learn about fungal metabolism and physiology especially in context of surfactant production. You will use up-to-date synthetic biology tools, analytical methods, and cultivation technologies. Computational biology, data management, and automation are incremental parts of the work.

As a Doctoral researcher at VTT, you are able to make an impact on our customers and society. Our researchers work closely together with industry, often in interdisciplinary research groups. VTT has excellent research infrastructure and internal services to support your research work. VTT has also started a Doctoral Programme to support goal-oriented PhD work within VTT’s strategic research choices. Once you have completed your PhD, we offer an exciting career opportunity with emphasis on applied research, working closely with our customers.

Our team, Production host engineering works on metabolic engineering of large number of known and non-conventional fungal hosts for production of various products e.g., lipids and derivatives, organic acids, colourants, or flavours and fragrances. We contribute to current and future production methods of food compounds and ingredients in cellular agriculture, chemicals and small molecules and materials.

Learn more about our research:

Microbial pigments

As a PhD student, you will:

  • Conduct scientific project work in the fields of metabolic engineering and synthetic biology for generation of surfactants
  • Actively participate in a multi-disciplinary research team to form research ideas and technical solutions to execute them
  • Participate in discussions with industry to help solve their challenges

Who we are looking for:

  • Completed MSc in relevant field such as biochemistry, genetics, or microbiology
  • Excellent laboratory skills and experience in molecular biology techniques
  • Experience working either with bacteria, yeast or filamentous fungi
  • Strong spoken and written English skills
  • It’s a benefit if you have experience with biochemistry, chemistry, and/or computational methods

As a person, we hope that you are:

  • Motivated and willing to take initiative in getting projects accomplished with a “can do” attitude
  • Able to work both independently and as a member of a team
  • Curious towards cross-disciplinary approaches and technological challenges
  • Willing to conduct part of the project in a collaborator’s laboratory in Sweden
  • You are target-driven both with your decision-making and in learning new things and growing professionally

With VTT, you’ll enjoy:

  • Natural sciences with an impact. VTT works on the cutting-edge of natural sciences, and we’ve invested in building state-of-the-art research facilities for natural sciences, such as the Bioruukki pilot infrastructure for bio- and circular economy. Our research agenda is dedicated to solving systemic and technological challenges, such as reaching carbon neutrality and unleashing the power of synthetic biology. That means that at VTT, your expertise in natural sciences will go towards creating a real impact. Read more about our strategy – the path of exponential hope .
  • Superb colleagues and community. With VTT, you’ll join a community of over 2000 multidisciplinary experts who foster a culture of trust, openness, and sharing of knowledge. We work across disciplines and house all the cutting-edge sciences, from quantum computing to synthetic biology, under one roof. Collaborating with superb colleagues is a source of learning, inspiration, and fun. Read more about our organisational culture as the builder of the world’s most meaningful place to work.
  • Excellent career in research. At VTT, excellence in research is a strategic priority. We offer long-term positions and stable career paths in top-level research. People tend to stay with us for over ten years since there are always new roles and responsibilities to grow into. A combination of cutting-edge academic research and applied customer projects keeps your career path interesting.
  • Support for your well-being. Our people are our main asset, so we take good care of them. We aim to nurture excellent team spirit and leadership and offer versatile well-being services to enable a good work-life balance. On top of 6 weeks of paid holidays, we offer exercise and culture benefits, hobby clubs, and voluntary well-being services such as meditation and cognitive ergonomics training.

Apply now and join our community of brilliant minds!

Please send your CV and answer to the preliminary screening questions with your salary request via our recruitment system as soon as possible but at the latest by 18th of January 2024. We will make our first screening anonymously based on the answers you have provided to the open questions and we will process applications as they come in and fill the position as soon as we find the right candidate. A security clearance procedure may be conducted during the recruitment process.

Interested and want to know more?

For further information, please contact Principal scientist Peter Richard, peter.richard@vtt.fi, +358405186027 or Research Team Leader Mervi Toivari, mervi.toivari@vtt.fi, +358407081039 on 12th or15th of January at 1-3 pm.

We look forward to hearing from you!

VTT

VTT is a visionary research, development and innovation partner. We drive sustainable growth and tackle the biggest global challenges of our time and turn them into growth opportunities. We go beyond the obvious to help the society and companies to grow through technological innovations. We have 80 years of experience of top-level research and science-based results. VTT is at the sweet spot where innovation and business come together.

VTT – beyond the obvious.

Location: Tekniikantie 21, Espoo

Research technician/laboratory coordinator – University of Helsinki

7.1.2024 | Ajankohtaista

https://www.linkedin.com/jobs/view/3789364366

About the job

The Evolution, Conservation, and Genomics research group, led by Professor Craig Primmer ( https://www.helsinki.fi/en/researchgroups/evolution-conservation-and-genomics ),

is looking for a

RESEARCH TECHNICIAN/LABORATORY COORDINATOR (Genomics and molecular biology)

for the period of 1.2.2024 – 31.12.2025 (the starting date can be negotiated) to assist an international team in conducting molecular biology and genomic analyses e.g. DNA and RNA extraction, next-generation sequencing (e.g. bulk and single-cell RNA-seq), targeted SNP assay development and analysis, cell biology and histology techniques. Additional tasks may include ordering reagents, database maintenance, helping maintain experimental Atlantic salmon and rainbow trout populations, measuring and sampling fish and assisting other lab members as needed.

The successful candidate will likely have experience with at least some of the above-mentioned techniques and be enthusiastic about learning others. They will mainly work under the supervision of post docs and/or PhD students .We are looking for a highly motivated candidate with excellent organizational skills and good English communication skills. We appreciate a cooperative attitude and enthusiasm for learning new techniques and skills.

The salary is based on levels 6-8 of the job requirement scheme for other personnel in the salary system of Finnish universities. In addition, the appointee will be paid a salary component based on personal work performance. The position is offered with a six-month trial period.

Applicants are requested to submit their application, as one single pdf file, which includes the following documents:

  • CV including contact details for at least 2 referees
  • motivation letter (max 1 page).

The application must be submitted through the University of Helsinki electronic recruitment system by clicking on Apply for the position. Internal applicants (i.e., current employees of the University of Helsinki) must submit their applications through the SAP HR portal. The closing date for applications is 15.1.2024.

Further information is available from Professor Craig Primmer, craig.primmer(at)helsinki.fi.

2 Postdoctoral researchers in Molecular Plant Physiology and Biochemistry – University of Helsinki

7.1.2024 | Ajankohtaista

https://www.linkedin.com/jobs/view/3791297414

About the job

The University of Helsinki Organismal and Evolutionary Biology Research Programme and the research groups of Prof. Jaakko Kangasjärvi , Dr. Maija Sierla and Dr. Cezary Waszczak are seeking to hire two highly motivated Postdoctoral Researchers to study Arabidopsis thaliana guard cell signalling.

Project Descriptions

The projects aim at molecular-level understanding of guard cell signalling and stomatal function in response to environmental stimuli. We also address connections between stomatal and vascular function. We use forward- and reverse-genetics, interactomics, and phosphoproteomics approaches coupled with plant physiology, molecular and cell biology and biochemistry to identify new components in guard cell signalling networks and further characterize the components we have previously identified.

Project 1: We have recently conducted a forward genetic screen aiming at saturation of Arabidopsis thaliana guard cell signalling network. Through an ozone-sensitivity approach combined with whole-rosette gas exchange analysis we identified over 50 novel mutants impaired in stomatal closure ( Sierla et al., 2018 ; Takahashi et al., 2022 ; Waszczak et al., 2023 ). One of the successful candidates will be involved in mapping and functional characterization of the newly identified mutants. This project will be performed in close collaboration between research groups of Prof. Kangasjärvi, Dr Maija Sierla and Dr Cezary Waszczak.

Project 2: We are using interactomics (Co-IP and TurboID) and phosphoproteomics approaches, and suppressor mutant screens with known stomatal regulators to further characterize the guard cell signalling pathways regulating stomatal movements in response to both abiotic and biotic stimuli. We also investigate the coordination of stomatal and vascular function. Our main focus is on the receptor-like pseudokinase GHR1 ( Sierla et al., 2018 ; Hõrak et al., 2016 ) and its novel interactors. One of the successful candidates will lead some of these research lines based on their expertise and interest in the group of Dr Maija Sierla.

The candidates will be integrated into an international research team of experts in plant stress biology and environmental signalling and participate in extensive collaborations, including mobility exchanges within Europe.

Qualifications:

  • doctoral degree in molecular or cell biology, plant biology, biochemistry or other relevant field
  • experience in plant physiology, molecular plant sciences and/or biochemistry (proteomics, interactomics, phosphoproteomics, kinase assays)
  • ability to conceive, execute, and complete research projects
  • creativity and independent thinking
  • excellent written and verbal communication skills

Research Environment

The University of Helsinki, founded in 1640, is one of the world’s leading universities for multidisciplinary research. The university has an international academic community of 40,000 students and staff members. The University of Helsinki offers comprehensive services to its employees, including occupational health care and health insurance, sports facilities, and opportunities for professional development.

The projects are funded by the Research Council of Finland Centre of Excellence in Tree Biology that brings together ten PIs from the University of Helsinki (UH) and two from the Natural Resources Institute Finland (Luke), who together with a large network of international collaborators form a multidisciplinary team of experts in plant genetics, physiology and computational modelling. The Organismal and Evolutionary Biology Research Programme operates at the University of Helsinki Viikki Biocenter which is the largest hub for molecular plant biology in Finland. The Viikki Biocenter has exceptional research facilities, including state-of-the-art core facilities such as plant growth chambers, greenhouses, and a high-throughput plant phenotyping facility.

Employment Conditions

  • the earliest starting date is 1st of March 2024
  • fixed-term contract (6 months trial period) of 2-3 years with a possibility for extension
  • starting salary ca. 3300 – 3800 EUR/month depending on the qualifications and experience
  • occupational healthcare

How To Apply

The application should include the following attachments as a single pdf-file (in English):

  • a cover letter describing shortly your background and motivation to apply to this position (max. 2 pages). In the cover letter specify which position you are most interested in.
  • CV including a list of publications (if any) with a brief summary explaining your own contributions
  • Names and contact information of two referees, who are willing to provide reference letters upon request

Please submit your application using the University of Helsinki Recruitment System via the apply link. The deadline for submitting the application is 30th of January 2024. The call may close earlier if suitable candidates are found.

For more information please contact Jaakko Kangasjärvi ( jaakko.kangasjarvi@helsinki.fi ), Maija Sierla ( maija.sierla@helsinki.fi ) or Cezary Waszczak ( cezary.waszczak@helsinki.fi ). For more information on the research groups please visit our websites:

Jaakko Kangasjärvi: https://researchportal.helsinki.fi/en/organisations/plant-ros-signalling

Maija Sierla: http://www.helsinki.fi/plant-environmental-signalling

Cezary Waszczak: https://www.helsinki.fi/en/researchgroups/cell-wall-and-epidermal-integrity

References

Hõrak H, Sierla M, Tõldsepp K, Wang C, Wang Y-S, Nuhkat M, Valk E, Pechter P, Merilo E, Salojärvi J, Overmyer K, Loog M, Brosché M, Schroeder J, Kangasjärvi J and Kollist H (2016) A dominant mutation in the HT1 kinase uncovers MAP kinases and GHR1 in CO2-induced stomatal closure, The Plant Cell, 10: 2493-2509

Sierla M, Hõrak H, Overmyer K, Waszczak C, Yarmolinsky D, Maierhofer T, Vainonen JP, Salojärvi J, Denessiouk K, Laanemets K, Tõldsepp K, Vahisalu T, Gauthier A, Puukko T, Paulin L, Auvinen P, Geiger D, Hedrich R, Kollist H, Kangasjärvi J (2018) The receptor-like pseudokinase GHR1 is required for stomatal closure. The Plant Cell 30: 2813–2837

Takahashi Y, Bosmans KC, Hsu PK, Paul K, Seitz C, Yeh CY, Wang YS, Yarmolinsky D, Sierla M, Vahisalu T, Waszczak C, McCammon JA, Kangasjärvi J, Zhang L, Kollist H, Trac T, Schroeder JI (2022) Stomatal CO2/bicarbonate sensor consists of two interacting protein kinases, Raf-like HT1 and non-kinase-activity activity requiring MPK12/MPK4. Sci Adv 8: eabq6161

Waszczak C, Yarmolinsky D, Leal Gavarrón M, Vahisalu T, Sierla M, Zamora O, Carter R, Puukko T, Sipari N, Lamminmäki A, Durner J, Ernst D, Winkler JB, Paulin L, Auvinen P, Fleming AJ, Andersson MX, Kollist H, Kangasjärvi J (2023) Synthesis and import of GDP-l-fucose into the Golgi affect plant–water relations. New Phytologist. doi: 10.1111/nph.19378

Tutkijatohtori / erikoistutkija B-solujen ja virusantigeenien tutkimukseen – Turun yliopisto

7.1.2024 | Ajankohtaista

https://duunitori.fi/tyopaikat/tyo/tutkijatohtori-erikoistutkija-b-solujen-ja-virusantigeenien-tutkimukseen-stsur-17666358

Työpaikkakuvaus

Dosentti Pieta Mattilan tutkimusryhmään haetaan tutkijatohtoria/erikoistutkijaa projektiin, jossa selvitetään virusantigeenien prosessointia ja esittelyä B-soluissa, tavoitteena ymmärtää paremmin tämän prosessin roolia ja siihen vaikuttavia tekijöitä rokotevasteessa. Valitun hakijan toivotaan aloittavan 1.3.2024 (tai sopimuksen mukaan). Tehtävä täytetään kaksivuotisena, mutta on mahdollista, että tehtävä jatkuu.

Ryhmämme tutkii B lymfosyyttien aktivaatiota, mikä mahdollistaa suojaavien korkean affiniteetin omaavien vasta-aineiden muodostumisen. Käytämme paljon moderneja mikroskopian ja proteomiikan työkaluja yhdistettynä soluaktivaatiokokeisiin sekä hiirimalleihin, joiden avulla pyrimme paremmin ymmärtämään B-solujen aktivaation säätelyä. Läpimenevänä tavoitteenamme on löytää uusia kohteita lääkekehittelyyn B-solulähtöisiin lymfoomiin tai immuunijärjestelmän häiriöihin, kuten immuunipuutoksiin tai autoimmuunisairauksiin, ja toisaalta löytää työkaluja tehokkaampien rokotteiden kehittelyyn.

Lisätietoa ryhmästämme löytyy: https://mattilalab.utu.fi

Tehtävästä

Palkattava henkilö tulee työskentelemään osana EU-rahoitettua (Horizon Europe) projektia Yellow4FLAVI ( Deconstructing the protective immunity of yellow fever virus 17D to inform flavivirus vaccine design ). Yellow4FLAVI konsortio käsittää 13 partneria 7 eri maasta. Konsortiota koordinoi Prof. Giovanna Barba-Spaeth Institute Pasteurista, (Pariisi, Ranska). Meidän osuutemme on tutkia keltakuumeviruksen antigeenin prosessointia ja esittelyä B-soluissa. Työ sisältää erilaisten mikroskopiatekniikoiden käyttöä ja kehittelyä sekä soluaktivaatiokokeiden pystyttämistä kyseistä tarkoitusta varten tiiviissä yhteistyössä Ranskassa ja Saksassa sijaitsevien kollaboraattoreidemme kanssa.
Yellow4FLAVI projektin taustaa hieman: Aiemmin suurimmaksi osaksi tropiikkiin liitetyt flavivirukset, kuten Zika, dengue, Länsi-Niilinvirus ja keltakuume ovat laajenemassa globaaliksi terveysuhaksi. Ilmastonmuutos ja kaupungistuminen ovat edesauttaneet viruksia levittävien hyttysten alueiden laajenemista ja Euroopassa onkin viime vuosina havaittu useita paikallisesti leviäviä epidemioita. Keltakuumevirus 17D (YF17D) on heikennetty viruskanta, jolla saavutetaan rokotevaste, joka on ylitse muiden tehokkuudessa ja turvallisuudessa. Rokotteen menestyksestä huolimatta emme ymmärrä, mikä tekee siitä niin erinomaisen. Yellow4FLAVI konsortio pyrkii ymmärtämään näitä mekanismeja, yhdistäen viruksen rakenteen saavutettuun immuunivasteeseen, tavoitteena oppia kehittämään parempia rokotteita myös muita flaviviruksia vastaan.

Postdoctoral Researcher/Project Researcher, NEMESIS – University of Eastern Finland, Kuopio

7.1.2024 | Ajankohtaista

https://www.linkedin.com/jobs/view/3789870345

About the job

The University of Eastern Finland is inviting applications for a a Postdoctoral Researcher/Project Researcher position on the Kuopio Campus. The position will be filled  from 1 February 2024 onwards (or as agreed). Please find more information below and submit your application by 15 January 2024.

Role and salary

As our new Postdoctoral Researcher/Project Researcher, you will be working in the School of Pharmacy at the Faculty of Health Sciences within the EU-funded NEMESIS consortium that aims to develop “novel effect biomarkers for metabolic disruptors: evidence on health impacts to answer science and policy needs”. The position is located in Kuopio, Finland.

You will develop, prevalidate and use nuclear receptor (NR)-based reporter assays to measure the detailed dose-response activation of key NRs by metabolism-disrupting compounds (MDCs), relevant microbiome-derived compounds and their mixtures with human, mouse and zebrafish reporter gene assays. The effects of MDC biotransformation will be studied in stable cell lines expressing cytochrome P450 enzymes. Effects of MDCs and their mixtures on hepatic NR target gene expression will be analysed in select cases by RNA sequencing.

More information about the principal investigator: https://uefconnect.uef.fi/en/person/paavo.honkakoski/

The position is filled for a fixed term until 31 December 2026, with a preferable start date in February 2024 or as agreed. The position will be filled for a fixed term due to it pertaining to a specific project. A probationary period is applied to all new members of the staff.

The salary of the position is determined in accordance with the salary system of the Finnish universities. The salary comprises two components: a job requirement component and a personal performance component. In this position, the job requirement component is 3150,54 euros/month, based on level 5 of the job requirement chart for teaching and research staff. The personal performance component can be a minimum of 6 % and a maximum of 50 % of the above-mentioned sum.  Depending on the personal performance component, the salary will be approximately 3 460 – 3 850 €/month at the beginning of the employment.

Our requirements and expectations

Requirements

  • A doctoral degree in a relevant discipline and solid training and expertise in molecular biology, cell culture and gene expression methods appropriate for this project
  • The doctoral degree may not have been completed more than five years ago at the time of accepting the position (a net period of time, which does not include parental leaves, military service etc.). If the person to be appointed has received a doctoral researcher more than five years ago, the position will be filled as a Project Researcher.
  • Solid experience in the use of hepatic and intestinal cell models (e.g., primary hepatocytes, HepG2, HepaRG, Caco-2) and reporter gene assays or RNA sequencing will be considered an advantage. Please indicate the specific use of these models and techniques in your application by citing a publication or manuscript in your motivation letter.
  • Excellent skills in oral and written English. English is used as the language of instruction and supervision in this position
  • Proficient computer and data management skills
  • An independent approach to doing research

Expectations/advantages

  • experience in project management
  • experience in the supervision of academic theses
  • verbal and written presentation skills
  • grant funding received

Your benefits

You will have access to the university’s staff benefits, including

  • opportunity for flexible multi-location work
  • extensive occupational health care
  • broad selection of staff training
  • staff discount on lunch in our campus restaurants, as well as on a range of other services
  • affordable sports services and tax-free bike benefit

Please read more in the Work at UEF section on our website.

You will have an opportunity to work in an interesting/meaningful/diverse role as part of our international, creative, participatory and inclusive academic community.

Enjoy your life in Finland! Known for its cleanliness, welfare know-how, modern technology and superb education system, Finland is an exotic and safe country to work in. Please visit the Life in Finland section on our website to learn more.

How to apply?

Submit your application by using our electronic application form no later than 15 January 2024 by 24:00 (midnight) Finnish time (UTC+2)

Please note that you must include the following appendices in your application:

  • CV (https://tenk.fi/en/advice-and-materials/template-researchers-curriculum-vitae)
  • a list of publications (https://www.aka.fi/en/research-funding/apply-for-funding/how-to-apply-for-funding/az-index-of-application-guidelines2/list-of-publications/)
  • copy of the applicant’s highest academic degree certificate
  • an Appendix listing experience in e.g. academic teaching, grant funding obtained and other research merits not present in the CV
  • motivation letter
  • other documents to demonstrate the applicant’s merits for the position

In addition, attaching at least two reference letters is highly encouraged.

Questions?

For further information on the position, please contact Professor Paavo Honkakoski, +358 29 445 4302, email. paavo.honkakoski@uef.fi

For further information on the application procedure, please contact HR Secretary, Sari Palviainen, email. sari.palviainen@uef.fi , +358 29 445 4324

The Faculty of Health Sciences operates at the Kuopio Campus of the University of Eastern Finland. The Faculty offers education in medicine, dentistry, nutrition and pharmacy, as well as in some other central fields of the health care sector. The Faculty is research-intensive, and its internationally recognised research activities are closely linked to the strategic research areas of the University. There are approximately 3 090 degree students and about 580 PhD students in the Faculty. The faculty has 800 staff members.

The University of Eastern Finland (UEF) is the most multidisciplinary university in Finland. Our university employs approximately 3,200 experts, and our community includes approximately 16,000 degree students and 16,000 adult education students. Our campuses are located in Joensuu and Kuopio. We represent the world’s cutting edge of research in many fields and produce research-based knowledge, which is made openly available to benefit everyone. Learn more about our university at www.uef.fi/en. Read also about UEF as a working community and employer and the career stories of our employees.

Työsopimuksen voimassaolo: määräaikainen työsopimus | Työsuhteen luonne: kokoaikainen | Paikkojen lukumäärä: 1 | Työllisyysaste: 100 | Paikkakunta: Kuopio | Maakunta: Pohjois-Savo | Maa: Finland | Ilmoitusnumero: 4819/01.01.03/2023 | Yhteys: Paavo Honkakoski +358294454302, | Julkaistu: 2023-12-19 | Haku päättyy: 2024-01-15

Doctoral researcher in Computational biology – Aalto University

7.1.2024 | Ajankohtaista

https://www.linkedin.com/jobs/view/3789354847

About the job

Aalto University is where science and art meet technology and business. We shape a sustainable future by making research breakthroughs in and across our disciplines, sparking the game changers of tomorrow and creating novel solutions to major global challenges. Our community is made up of 13 000 students, 400 professors, and more than 4 500 other faculty and staff working on our dynamic campus in Espoo, Greater Helsinki, Finland. Diversity is part of who we are, and we actively work to ensure our community’s diversity and inclusiveness. This is why we warmly encourage qualified candidates from all backgrounds to join our community.

The School of Chemical Engineering is one of the six schools of Aalto University. It combines natural sciences and engineering in a unique way.

We are now looking for a

Doctoral researcher in Computational biology

The Biochemistry group and the Microbial physiology group develop methanogenic archaea as cell factories for CO2 valorisation within a collaborative project funded by the Erkko Foundation. To complement the team that consists of three doctoral researchers that are jointly supervised by Profs Jouhten and Scheller, we are looking for a doctoral researcher in computational biology.

Scientific environment

The Department of Bioproducts and Biosystems (BIO2), one of three departments in the School of Chemical Engineering at Aalto University, has an internationally leading reputation in basic and applied research for the development of advanced materials from natural resources. It is one of Europe’s leading research and higher education institutions in the field of sustainable chemistry and engineering based on the utilization of renewable resources.

BIO2 aims to contribute to the development of novel solutions to move towards sustainable primary production and processing systems that can produce materials with fewer inputs, less environmental impact, and reduced greenhouse gas emissions. Within bioscience, the department has research in bioprocess technology, molecular biotechnology, enzyme technology, metabolic engineering, synthetic biology, biomolecular, and biohybrid materials. Other strengths of the department include sustainable materials and products based on lignocellulose, ranging from nanomaterials to novel cellulose-based textiles.

Research Description

The key aims of the overall project are: 1) Elucidating the best-suited microbe for CO2-valorization. 2) Engineering the cellular regulation to redirect carbon flux from CO2 to desired products. 3) Demonstrating multi-carbon compound production via methanogens.

These aims are targeted by a collaborative effort of three PhD students with diverse backgrounds, combining bioinformatics, microbiology and metabolic engineering.

Research is carried out at our excellent facilities at Aalto University, School of Chemical Engineering (http://www.bioeconomyinfra.fi). The laboratories are situated on the main campus of Aalto University in Otaniemi (short metro-ride from Helsinki) within the Department of Bioproducts and Biosystems.

Your Experience And Ambitions

  • MSc degree
  • Solid understanding of molecular biology
  • Background in programming and data science
  • Aptitude to become an expert for applying python and R in biotechnology
  • Carry out some labwork, in addition to the development of computational algorithms
  • Ability and interest to work smoothly and results-oriented in an interdisciplinary team
  • High self-motivation and persistence in tackling challenging scientific problems
  • Good written and oral communication skills in English

What We Offer

  • High-end laboratory infrastructure and friendly colleagues
  • Opportunity to be part of two uprising, ambitious research groups
  • Freedom to bring in own ideas
  • Funding is reserved for 4 years

Doctoral studies at Aalto University take approximately four years. The candidate will be granted a one-year contract with the possibility of extension. The starting salary for a doctoral candidate is approximately 2600 EUR/month and will increase with responsibilities and performance over time.

If you are chosen for this position, you will apply for the study right in doctoral studies at Aalto University School of Chemical Engineering. Thus, please check the student information and admission criteria at https://www.aalto.fi/en/study-options/aalto-doctoral-programme-in-chemical-engineering. In particular, please pay attention to the mandatory skill level in English.

Ready to apply?

If you want to join our community, please submit the following application materials as a single PDF document in English through the ’Apply’ link by Jan. 20th, 2024:

  • Cover letter (start as follows: “I am interested in this position because… “, then describe how you fulfil the job requirements)
  • CV
  • Research interest description (for future research)
  • Names and contact details of references (or to be provided upon request)

Aalto University’s employees and visitors should apply for the position via the internal HR system Workday (keyword Find Jobs) by using their existing Workday user account (not via the external webpage for open positions).

For additional scientific information, please contact Prof. Paula Jouhten (firstname.lastname@aalto.fi) or Prof. Silvan Scheller (firstname.lastname@aalto.fi).

Want to know more about us and your future colleagues? You can watch these videos: Aalto University – Towards a better world, Aalto People, and Shaping a Sustainable Future. You can also check out our webpage about Aalto and Finland: https://www.aalto.fi/en/services/welcome-to-aalto-university-and-finland-info-package and our new virtual campus experience: https://virtualtour.aalto.fi/.

About Finland

Finland is a great place for living with or without family – it is a safe, politically stable, and well-organized Nordic society. Finland is consistently ranked high in quality of life and was just listed again as the happiest country in the world: https://worldhappiness.report/news/its-a-three-peat-finland-keeps-top-spot-as-happiest-country-in-world/. For more information about living in Finland: For international staff | Aalto University

Aalto University reserves the right for justified reasons to leave the position open, to extend the application period, and to consider candidates who have not submitted applications during the application period.

More about Aalto University:

Aalto.fi

twitter.com/aaltouniversity

facebook.com/aaltouniversity

instagram.com/aaltouniversity

Laboratory Technician – Radiometer, Turku

7.1.2024 | Ajankohtaista

https://www.linkedin.com/jobs/view/3787300654

About the job

In our line of work, life isn’t a given – it’s the ultimate goal. When life takes an unexpected turn, our technology and solutions enable caregivers to make informed diagnostic decisions to improve patient care. This is our shared purpose at Radiometer and what unites all +4000 of us – no matter our roles or where in the world we’re located. Creating impactful innovations like ours, doesn’t happen overnight – it requires uncompromising persistency, passion, and a desire to make a difference. Here, you can learn, grow, and chart an uncommonly diverse career.

Radiometer is proud to work alongside a community of six fellow Diagnostics Companies at Danaher. Together, we’re working at the pace of change to improve patient lives with diagnostic tools that address the world’s biggest health challenges.

R&D Functions are looking for three new Laboratory Technicians, Assay Development AURA.

The Laboratory Technician for Radiometer works as part of a project team, developing new immunoassay products.

This position is part of the Radiometer Turku Oy located in Turku, Finland and the position will be on-site. The position is temporary, and the estimated duration of the temporary contract is until December 2025. At Radiometer, our vision is to improve global healthcare with reliable, fast, and easy patient diagnoses.

You will be a part of the Assay Development AURA team and report to the Senior Manager, Assay Development AURA. Laboratory Technician will be responsible for planning, performing, and reporting laboratory tests and maintaining the laboratory equipment and environment.

In this role, you will have the opportunity to:

  • Share knowledge and learn in an international and diverse group of highly motivated professionals, by being involved in cross-site and cross-functional collaboration.
  • Work in the field of medical technologies, making a difference in a company whose products can truly impact other people’s lives.
  • As part of Radiometer and Danaher you have many opportunities for training and career development and a wide range of staff benefits.

The essential requirements of the job include:

  • B.Sc. in Life Sciences or equivalent or other suitable laboratory education.
  • Knowledge on basic principles in immunoassays.
  • Fluency in written and in spoken English and at least basics in Finnish.

It would be a plus if you also possess previous experience in:

  • Microsoft Excel (data handling) and Microsoft Office skills.
  • Continuous improvement attitude combined with good problem-solving skills.
  • A background of immunochemistry and quality systems (ISO13485), as well as understanding of LEAN principles.
  • We value a teammate with strong cooperative skills and positive mindset.

For further information, please contact Senior Manager, Assay Development AURA Annina Siltanen by mail annina.siltanen@radiometer.fi or by mobile +358 41 524 6898 (Best time to reach me is on Mon 18.12 between 8-10 AM, Wed 20.12 between 3-5 PM and Fri 22.12 between 8-10 AM). The recruitment will be completed as soon as a suitable candidates are found.

When you join us, you’ll also be joining Danaher’s global organization, where 80,000 people wake up every day determined to help our customers win. As an associate, you’ll try new things, work hard, and advance your skills with guidance from dedicated leaders, all with the support of powerful Danaher Business System tools and the stability of a tested organization.

At Danaher, we value diversity and the existence of similarities and differences, both visible and not, found in our workforce, workplace and throughout the markets we serve. Our associates, customers and shareholders contribute unique and different perspectives as a result of these diverse attributes.

If you’ve ever wondered what’s within you, there’s no better time to find out.