Eliisa Kekäläinen’s research group “Inborn and acquired immunodeficiencies” at the Translational Immunology Research Program at University of Helsinki, Faculty of Medicine invites applications for the position of
POSTDOCTORAL RESEARCHER
Our research group focuses on the human thymus which produces key immune cells, the T cells. We 1) evaluate and develop methods to better measure thymopoiesis, 2) study how thymopoiesis and the thymus itself is affected by viral infections, and 3) aim to understand how and why certain autoimmune diseases, such as myasthenia gravis, develops. We use thymic tissue samples from both immunologically healthy individuals and patients with cutting edge techniques including thymic organ cultures and different multi-dimensional single-cell methods to dissect the normal and pathological processes in the thymus. We are seeking for a motivated post-doctoral researcher to work on Research Council of Finland – funded project.
Qualifications
Applicants with a doctoral degree and strong background in immunology or other relevant life science fields who are interested in working in an inter-disciplinary environment are particularly encouraged to apply. Applicant must be able to work independently and have good communication skills in English. The chosen applicant is expected to reside in Finland while employed by the University of Helsinki.
The person we are looking for has:
effective communication and collaboration skills
proven track record in designing and executing experimental science
motivation and determination to learn (more) immunology
Furthermore, if you have experience with the topics below, we would love to hear about your
supervision experience
working with tissue samples or organoid cultures
experience in flow cytometry, single-cell omics, CRISPR-Cas or immunohistochemistry
What We Offer
The appointment will be initially for two years starting from January 2024 (possibility to start earlier or later if needed). Trial period of six months will be applied. The monthly gross salary will be appr. 3200-3600 € per month depending on the appointee’s qualifications and experience. In addition, University of Helsinki offers comprehensive services to its employees, including occupational health care and opportunities for professional development. Applicants of any gender, linguistic and cultural background or from members of minority groups are welcomed. You can read more about working at the university on our website .
We offer you on top of these benefits an opportunity to explore and learn in a team that shares a passion for immunology. The team’s well-being is top priority in our laboratory.
How To Apply
Please submit your application as a single PDF file containing your CV, a publication list where you describe your own role in the publications that you consider the most relevant for the position, and two letters of reference. The application will be submitted through the University’s electronic recruitment system by clicking “Apply now” link. Applicants who are currently employed by the University of Helsinki are requested to submit their application via the SAP Fiori portal at https://msap.sap.helsinki.fi. The deadline for applications is 30 October 2023. Applications will be considered on a rolling basis until a suitable candidate is found.
For further information on the position, please contact Eliisa Kekäläinen (eliisa.kekalainen(at) helsinki.fi).
For information on the recruitment process, please contact HR Specialist Marja Meresto (hr-ltdk (at) helsinki.fi).
Selected publications from Kekäläinen lab:
Hetemäki I, Kaustio M, Kinnunen M, Heikkilä N, Keskitalo S, Nowlan K, Miettinen S, Sarkkinen J, Glumoff V, Andersson N, Kettunen K, Vanhanen R, Nurmi K, Eklund KK, Dunkel J, Mäyränpää MI, Schlums H, Arstila TP, Kisand K, Bryceson YT, Peterson P, Otava U, Syrjänen J, Saarela J, Varjosalo M, Kekäläinen E. Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells. Sci Immunol. 2021 Nov 26;6(65):eabe3454. doi: 10.1126/sciimmunol.abe3454.
Sarkkinen J, Dunkel J, Tuulasvaara A, Huuskonen A, Atula S, Kekäläinen E, Laakso SM. Ectopic germinal centers in the thymus accurately predict prognosis of myasthenia gravis after thymectomy. Mod Pathol. 2022 Sep;35(9):1168-1174. doi: 10.1038/s41379-022-01070-2.
Kleino I, Nowlan K, Kotimaa J, Kekäläinen E. Optimising protein detection with fixable custom oligo-labelled antibodies for single-cell multi-omics approaches. Biotechnol J. 2022 Jun;17(6):e2100213. doi: 10.1002/biot.202100213.
Nguyen NA, Huang X, Cabrera LE, Pekkarinen PT, Nowlan K, Strandin T, Kantele A, Vapalahti O, Heinonen S, Kekäläinen E. A comprehensive assessment of four whole blood stabilizers for flow-cytometric analysis of leukocyte populations. Cytometry A. 2023 Apr;103(4):313-324. doi: 10.1002/cyto.a.24700. Epub 2022 Nov 1. PMID: 36279192.
Lusila P, Toivonen A, Jarva H, Vettenranta K, Lehtimäki S, Kekäläinen E. FASCIA Method in the Assessment of Lymphocyte Mitogen Responses in the Laboratory Diagnostics of Primary Immunodeficiencies. J Clin Immunol. 2023 Apr;43(3):653-661. doi: 10.1007/s10875-022-01417-z.
The Faculty of Medicine promotes high quality scientific research. It provides research-based undergraduate and postgraduate education in medicine, dentistry, psychology and logopedics, and an international Master’s Programme in Translational Medicine. It also offers psychotherapist education. In addition to its teaching and research activities, the faculty serves as a significant expert organisation in the healthcare sector and contributes to the discourse on ethics in the field. The faculty aims to be one of the best medical research faculties in the world, while reinforcing its status as a distinguished institution of multidisciplinary education in healthcare.
The Faculty of Medicine at the University of Helsinki constitutes the academic medical centre together with HUS Helsinki University Hospital and the Helsinki Institute of Life Science (HiLIFE). This medical centre has been successful in international comparisons, ranking among the top 10 medical campuses in Europe and the top 50 globally.
Research Programs Unit (RPU) of the Faculty of Medicine consolidates demonstrated research excellence, with focused research programs addressing the greatest challenges in human health.
We are looking for a skilled postdoctoral fellow with a background in neuroscience and/or human stem cell based neuronal models at the Institute for Molecular Medicine Finland FIMM , Helsinki Institute of Life Science, HiLIFE in the research groups of Professor Aarno Palotie ( Research Group Palotie ) and Dr. Olli Pietiläinen ( Research Group Pietiläinen ). The position is part of a research program that aims to discover biological mechanisms in schizophrenia and related neuropsychiatric disorders. The program bridges multidisciplinary group of researchers in the interface of genetic discoveries and multi-omic molecular biology using cell collections from over 6000 sequenced participants. The project combines state-of-art functional genomics and experimental cell biology approaches in human stem-cell derived neuronal models to discover how genetic risk factors identified in the disorders mediate their causative effects in human cells. The Pietiläinen laboratory is based at the Neuroscience Center and has close links with the Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard ( https://www.broadinstitute.org/stanley ). The Pietiläinen group is located at the Meilahti biomedical campus in Helsinki and is closely linked with research groups at the HiLIFE Institute for Molecular Medicine https://www.helsinki.fi/en/hilife-fimm (HiLIFE-FIMM) and the Faculty of Biological and Environmental Sciences https://www.helsinki.fi/en/faculty-of-biological-and-environmental-sciences . HiLIFE-NC offers a inspiring environment to solve fundamental challenges of brain functions as part of the multidisciplinary HiLIFE infrastructure https://www.helsinki.fi/en/helsinki-institute-of-life-science at the university of Helsinki. In Pietiläinen group you will be part of a striving scientific community utilizing state of the art technologies in genomics and cell biology for scientific discoveries of the brain.
Role description:
We are seeking a postdoctoral researcher to work on a multidisciplinary project that utilizes human induce pluripotent stem cells (iPSC) to model cellular processes involved in neuropsychiatric disorders. The primary goal is to use known genetic risk variants to identify quantifiable cellular phenotypes that underlie neuropsychiatric disorders. To this end we apply high-throughput multiple omics approaches such RNA sequencing and proteomics that are complemented by experimental molecular cell biology approaches in the in vitro model systems, including cellular assays and gene editing techniques in isogenic cell lines. We are looking for a person for planning, conducting, and co-supervising molecular biology and cellular experiments in human iPSCs.
Key Requirements
We are looking for a highly motivated and creative person with a primary interest in molecular cell biology using human iPSC derived neuronal models to discover mechanisms in neurological disorders, and to work in multidisciplinary team of clinical, wet lab, and computational scientists. Candidates should have a PhD in neuroscience or molecular and cell biology with experience in iPSC derived neuronal models. We require previous experience and skills in cell culture, molecular cell biology, iPSC models, and neural differentiation. The ideal candidate will have experience in these areas, and an interest in translating genetic discoveries into functional biology. Any previous experience in analysing and processing genomic and omic data is considered an advantage. The position is available from September 2023 onwards, or earlier, if required. It is a two-year fixed-term position, with a possibility of extension. Trial period of 6 months will be applied.
The salary will be based on level 5 of the demands level chart for teaching and research personnel in the salary system of Finnish universities. In addition, the appointee will be paid a salary component based on personal performance with the overall starting salary amounting to approximately 3600-4500 EUR per month, depending on the qualifications and previous relevant research experience of the candidate.
Please submit your application via the University of Helsinki Recruitment System by clicking the ‘Apply for the position button’ below. If you need support with the recruitment system, please contact recruitment@helsinki.fi.
Please attach the following documents to your application as a single PDF file:
CV (including publications)
cover letter (maximum 1 page) that details your past experience and motivation
contact details of at least two references
The deadline for applications is September 29th, 2023. Interviews will be conducted either in person or online. For more information on the position, please contact Dr. Olli Pietiläinen (olli.pietilainen@helsinki.fi).
University of Helsinki
The University of Helsinki (UH), founded in 1640, is a vibrant scientific community of 40,000 students and researchers. It is one of the leading multidisciplinary research universities and ranks among the top 100 international universities in the world. It is currently investing heavily in life sciences research. UH offers comprehensive services to its employees, including occupational health care and health insurance, sports facilities, and opportunities for professional development.
Helsinki Institute of Life Science
Helsinki Institute of Life Science (HiLIFE) is a new institute established in 2017 that supports high quality life science research across the University campuses and faculties. HiLIFE builds on existing strengths and new recruits and partnerships to create an attractive international environment for researchers to solve grand challenges in health, food, and environment. HiLIFE coordinates research infrastructures in life sciences and provides research-based interdisciplinary training.
Institute for Molecular Medicine Finland
The Institute for Molecular Medicine Finland (FIMM) is an international research unit focusing on human genomics and personalised medicine at the Helsinki Institute of Life Science (HiLIFE) of the University of Helsinki – a leading Nordic university with a strong commitment to life science research. As part of Academic Medical Center Helsinki in Meilahti campus FIMM collaborates locally with the Faculty of Medicine, Helsinki University Hospital and National Institute for Health and Welfare. FIMM is part of the Nordic EMBL Partnership for Molecular Medicine, composed of the European Molecular Biology Laboratory (EMBL) and the centres for molecular medicine in Norway, Sweden and Denmark, and the EU-LIFE Community
HiLIFE -Neuroscience Center
The Neuroscience Center is an international research unit within Helsinki Institute of Life Science (HiLIFE) of the University of Helsinki, a leading Nordic university with a strong commitment to life science research. The research focus of NC is on translational brain plasticity. We carry out research relevant for the human brain both in health and disease, and during development and aging, by applying versatile approaches and modern technology platforms. NC aims at making fundamental discoveries about brain functions and especially translate research findings into improvements in the treatment, prevention and diagnosis of psychiatric and neurological disorders. The research in NC spans across several scales from stem cell research and molecular neuroscience to systems and cognitive neuroscience in both animal and human models.The research groups of NC conduct research in neuroscience at the highest international level and actively apply the results for the benefit of the society. NC collaborates actively with other units of HiLIFE and faculties of the University of Helsinki, Helsinki University Central Hospital, and Neurocenter Finland.
The University of Eastern Finland is inviting applications for a part time (40 %) Research Director/Senior Researcher position at the Kuopio Campus. The position will be filled for a three-year term from 1 November 2023 onwards (or as agreed). Please find more information below and submit your application by 2 October 2023.
Role and salary
We are seeking talented researchers to develop new treatment strategies and gene therapy approaches to cardiovascular diseases by using preclinical and/or clinical research in cooperation with the Kuopio University Hospital (KYS). Your work will have a significant impact on the field of cardiovascular research and will help us develop new approaches to preventing and treating these devastating diseases. We are looking for passionate and self-driven individuals to contribute to strengthening UEF’s strategic profile in cardiovascular diseases.
As our new Research Director/Senior Researcher, you will be working at the A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences. The position is located in Kuopio, Finland.
Our Cardiovascular Research Community is a world leader in conducting gene therapy trials for the treatment of ischemic cardiovascular diseases, in pre-clinical and translational studies, and in manufacturing GMP-compliant gene medicines. This position is intended to further this research and to have a significant impact on the field of translational medicine that will help us develop effective strategies for personalised prevention, diagnostics, monitoring, and treatment of chronic cardiovascular diseases.
As our new Research Director/Senior Researcher in Cardiovascular Research, you will work as an expert within the Cardiovascular Research Community. The responsibilities will also include the supervision of doctoral dissertations, possibly teaching, and the acquisition of external funding.
The position will be filled for a part-time (40 %) three-year term from 1 November 2023 onwards (or as agreed). The position will be filled for a fixed term due to it pertaining to tasks connected to UEF Multimodal Approaches and Data Analytics in Translational Medicine development. A probationary period is applied to all new members of the staff.
The salary of the position is determined in accordance with the salary system for Finnish universities. The salary comprises two components: a job-related salary element and a personal salary element. In this position, the job -related salary element is €3673.96 – 4235.52 /month, based on levels 6–7 of the job requirement level chart for teaching and research staff. The personal salary element can be a minimum of 6 % and a maximum of 50 % of the above-mentioned sum. Depending on the job-related salary element and the personal salary element, the salary (40 %) will be approximately from €1616 – 2152 /month at the beginning of the employment relationship.
Our requirements and expectations
Requirements
a doctoral degree in a relevant field and a medical degree (licenced to practise medicine in Finland)
a strong track record of research in translational preclinical animal models and/or cardiovascular diseases
excellent/good skills in spoken and written English. English is used as the language of instruction and supervision in this position.
experience in externally funded research projects, an independent approach to conducing research.
Expectations/advantages
Being active in clinical practice
Expertise in viral vectors
Specialization in cardiology
Project management skills
Supervisory and teaching skills necessary for the position
Experience in international research cooperation
Collaboration skills
A positiven attitude
Your benefits
You will have access to the university’s staff benefits, including
opportunity for flexible multi-location work
extensive occupational health care
broad selection of staff training
staff discount on lunch in our campus restaurants, as well as on a range of other services
affordable sports services and tax-free bike benefit
Please read more in the Work at UEF section on our website.
You will have an opportunity to work in an interesting and meaningful role as part of our international, creative, participatory and inclusive academic community.
Enjoy your life in Finland! Known for its cleanliness, welfare know-how, modern technology and superb education system, Finland is an exotic and safe country to work in. Please visit the Life in Finland section on our website to learn more.
How to apply?
Submit your application by using our electronic application form no later than 2 October 2023 by 24:00 (midnight) Finnish time (UTC+3)
Please note that you must include the following appendices in your application
a list of publications (https://www.aka.fi/en/research-funding/apply-for-funding/how-to-apply-for-funding/az-index-of-application-guidelines2/list-of-publications/)
copies of your academic degree certificates / diplomas, and copies of certificates / diplomas relating to your language proficiency, if not indicated in the academic degree certificates/diplomas
motivation letter: A detailed letter explaining your interest in the project, how you believe you can contribute to our objectives, and why you consider yourself a strong fit for the role
Names and contact information for 2 referees
Other documents to demonstrate the applicant’s merits for the position.
Questions?
For further information on the position, please contact Professor Seppo Ylä-Herttuala, tel. +358 40 355 2075, seppo.ylaherttuala@uef.fi and Research Director Nihay Laham Karam, tel. +358 29 445 4157, nihay.laham-karam@uef.fi
For further information on the application procedure, please contact HR-secretary Tarja Salmi, tarja.salmi@uef.fi, +358 29 4458220
The Faculty of Health Sciences operates at the Kuopio Campus of the University of Eastern Finland. The Faculty offers education in medicine, dentistry, nutrition and pharmacy, as well as in some other central fields of the health care sector. The Faculty is research-intensive, and its internationally recognised research activities are closely linked to the strategic research areas of the University. There are approximately 3 090 degree students and about 580 PhD students in the Faculty. The faculty has 800 staff members.
The University of Eastern Finland, UEF, is one of the most multidisciplinary universities in Finland. We have a staff of 3,200 members, and our academic community comprises around 16,000 degree students. Our campuses are located in Joensuu and in Kuopio. Our research is ranked among the best in the world in several fields. We generate research-based knowledge and make it openly accessible for the benefit of all. To learn more about our university please visit our website at www.uef.fi/en. On our website, you’ll also find information about the university as a work community and as an employer (https://www.uef.fi/en/article/one-university-a-thousand-stories), as well as our employees’ career stories (https://www.uef.fi/en/career-stories).
The University of Oulu is one of the biggest and most multidisciplinary universities in Finland. We create new knowledge and innovations that help to solve global challenges. We offer you an international and inspiring working environment where you are given responsibility and can use your skills, develop yourself and do work that matters. Our flexible and family-friendly workplace makes it easy for you to balance work and leisure. The University of Oulu is ranked in the top 3% of the world´s universities.
We are now seeking a highly motivated
Doctoral Researcher
in molecular microbiology and bioinformatics to join us in the Ecology and Genetics research unit at the Faculty of Science.
Description Of The Project
The plant-produced one-carbon compounds, such as methane and methanol, are an abundant energy source supporting a vast community of methylotrophic microbes living on aboveground plant surfaces and in the internal plant compartments (endophytes, endosphere). The Academy Research Fellow project ”Methanotroph communities filtering methane produced by coniferous forest trees” aims to characterize the lifestyle of the methane-consuming bacteria living inside pine trees.
We will utilize metagenomics to identify bacterial communities that filter methane in the aboveground tissues of pine and to analyze the functional characteristics (genes, pathways) associated with the lifestyle. We will use fluorescent markers with cutting-edge microscopy and imaging techniques to study the colonization dynamics between pine hosts and key methanotrophs. Finally, we will analyze how these endophytic methane-consuming bacteria will affect the methane emissions of the pines. The project will bring new significant knowledge on the role and dynamics of methane in plant-microbe interactions in forest ecosystems.
As a Doctoral Researcher, you will perform laboratory experiments to isolate and identify new microbial species, design and create fluorescent strains for microscopy, and handle and analyze metagenomic sequencing data. Thus, solid skills and knowledge in microbiological or molecular biological laboratory work and bioinformatics are required. During the project, the Doctoral Researcher will gain comprehensive knowledge and hands-on experience in establishing and running scientific experiments involving plants and microbes. Also, the candidate will learn how to analyze the outcomes by utilizing various bioinformatics and image analysis techniques in collaboration with the research team. The Doctoral Researcher will benefit from international visits to labs or research partners out of Finland during the project.
The research will be conducted at the Ecology and Genetics Research Unit, University of Oulu. The unit has a vibrant research community with strong in-house expertise in plant-microbe research and microbial ecology in general. We have excellent microbiology and molecular biology laboratories and instrumentation concerning the project’s needs. The candidate will join the University of Oulu Graduate School (UniOGS), which provides the framework and conditions for high-quality, research-driven doctoral training.
You are the person we are looking for if you have:
A master’s degree, or be about to obtain one, in microbiology, molecular genetics, microbial bioinformatics, or another related field (the degree must be completed before starting the position)
High motivation and the ability to work efficiently both independently and as part of a team
Solid background knowledge in microbial genetics and genomics
Experience in conducting laboratory work by utilizing tools in molecular biology or microbiology
Previous experience in microbial bioinformatics, e.g., metagenomics, bacterial WGS, or amplicon sequencing, is considered an advantage
Fluent in written and spoken English
See also the requirements of the University of Oulu Graduate School
What we offer?
An ambitious and exciting research project that aims to answer globally significant research problems
You will become a part of a highly talented research group, that is working on strategically and globally significant research area.
You will receive support from your team and supervisor, so that you can excel in your research.
In addition to modern research facilities, we offer you personnel benefits such as free occupational healthcare, wellness benefit ePassi covering sport, culture, and well-being, and endless opportunities to develop your skills and competencies. Read more about other staff benefits.
Development and career options of the big organization.
Work that matters and a workplace that promotes flexibility and work-life balance. Read more about working with us.
Our Buddy Programme and Spouse Network support you and close ones in settling into Oulu.
We have an HR Excellence in Research -quality label, which is a recognition awarded by the European Commission for the development of researchers’ working conditions and careers.
Finland is one of the most livable countries in the world, with a high quality of life, safety, an excellent education system, and a competitive economy. Read more about living in Oulu.
Salary
The Doctoral Researcher position in the project is fixed term for 3.4 years and scheduled to be filled from October 2023 or as soon as possible thereafter.
The salary will be based on levels 2 – 4 of the demand level chart for teaching and research staff of Finnish universities. In addition, a salary component based on personal work performance will be paid (a maximum of 50 % of the job-specific component). The starting gross salary will be approx. 2300-2600 € per month (before taxes). A trial period of 6 months is applied for the position.
How to apply?
Interested? If yes, please apply by 15th of October, 2023 (23:59 Finnish local time) through our recruitment system
The application should be written in English and include the following documents in PDF format:
Motivation letter (max. 2 pages) – summarizing the applicant’s professional experience and expertise and describing why the applicant is interested in this position. Also, information on personal research interests, experience, and career goals is valuable to provide here
CV – following the guidelines of the Finnish Advisory Board on Research Integrity. The CV should include the contact information of two senior/experienced researchers who can provide reference letters
Certificates/Diplomas – scanned electronic copies of certificates and transcripts of the records of relevant previous degrees (MSc and BSc or equivalent). If the original documents are not in English/Finnish, each document must be accompanied by a certified translation into English
The eligible applicants fitting best in the profile expected for the position will be invited to an on-site or remote interview. All applicants will be notified during the selection process.
Contact Information
If you have any further questions, please contact Academy Research Fellow Janne Koskimäki, Ecology and Genetics Research Unit, Faculty of Science, University of Oulu, janne.koskimaki@oulu.fi
The Research Program Unit at the Faculty of Medicine, University of Helsinki invites applications for
a fixed-term, full-time Doctoral Researcher position.
The position is available from October 2023, with flexibility on the starting date, and extends until August 2027.
The Chen’s research group at University of Helsinki is seeking a motivated doctoral researcher to contribute to a core project funded by the Academy of Finland. The project aims to investigate the role of RNA splicing and tissue environment in shaping human macrophage diverse phenotypes during obesity. In this study, we will use cutting-edge single-cell and spatial omics technologies, develop novel computational methods, perform multimodal data analysis and integration, and experimental validation to uncover key factors steering the progression of obesity-associated metabolic disorders. The selected candidate will play a pivotal role in computational data analysis and method development. Individuals with a strong interest and background in computational biology/bioinformatics are strongly encouraged to consider this opportunity.
As the global concern over obesity escalates due to its significant contribution to various diseases, your work will enhance our understanding of novel cellular and molecular mechanisms driving the emergence of obesity-associated metabolic disorders. Join us in this pivotal endeavour to advance our understanding and address the pressing health challenges posed by obesity.
Qualifications
Eligibility requires a master’s degree in computational biology/bioinformatics or a relevant field. Proficiency in programming and a fervent curiosity to employ data science in deciphering biological mechanisms of human diseases are imperative. Candidates should exhibit adeptness in both independent work and collaborative team settings across diverse disciplines. Motivation, excellent time management, and effective communication skills in spoken and written English stand as essential attributes. Additionally, familiarity with immunology, metabolism, and RNA biology will be advantageous.
The starting salary will be set on level 2 of the national salary scale for teaching and research personnel at Finnish universities. In addition, salary component based on personal performance will be paid. The starting salary will be in the range of 2300-2600 euros/month (pre-tax). A six-month trial period will be applied.
Finland stands out as one of the world’s most liveable nations, boasting exceptional quality of life, safety, and renowned education system. The selected candidate will receive University of Helsinki staff benefits, including occupational health care services. Additionally, access to high-quality public childcare services, schools, and substantial family benefits is provided. The selected candidate will be based in Finland while employed by the University of Helsinki.
How To Apply
Application should include the following documents as a single pdf file in English:
A motivation letter detailing your prior knowledge, research interests, career goals, and compelling rationale for your suitability for this role.
A Curriculum Vitae, including a list of publications and contact details of 2 referees.
Certificates/Diplomas: Please provide scanned copies of diplomas and transcripts of your previous degrees. In instances where the original documents are not in English, Finnish, or Swedish, please provide an official certified translation into either English or Finnish.
To apply, the applications should be submitted through the University of Helsinki Recruitment System via the link ”Apply now” below. Applicants who are currently employed by the University of Helsinki are requested to submit their application via the SAP Fiori portal at https://msap.sap.helsinki.fi. The closing date for applications is 16 October 2023 (at 23.59 EEST). Applicants of any gender, linguistic and cultural background or from members of minority groups are welcomed. You can read more about working at the university on our website .
For further information on the position, please contact Dr. Ping Chen (ping.chen (at)helsinki.fi).
For information on the recruitment process, please contact HR Specialist Marja Meresto (hr-ltdk(at) helsinki.fi).
The Faculty of Medicine promotes high quality scientific research. It provides research-based undergraduate and postgraduate education in medicine, dentistry, psychology and logopedics, and an international Master’s Programme in Translational Medicine. It also offers psychotherapist education. In addition to its teaching and research activities, the faculty serves as a significant expert organisation in the healthcare sector and contributes to the discourse on ethics in the field. The faculty aims to be one of the best medical research faculties in the world, while reinforcing its status as a distinguished institution of multidisciplinary education in healthcare.
The Faculty of Medicine at the University of Helsinki constitutes the academic medical centre together with HUS Helsinki University Hospital and the Helsinki Institute of Life Science (HiLIFE). This medical centre has been successful in international comparisons, ranking among the top 10 medical campuses in Europe and the top 50 globally.
Research Programs Unit (RPU) of the Faculty of Medicine consolidates demonstrated research excellence, with focused research programs addressing the greatest challenges in human health.
Eliisa Kekäläinen’s research group “Inborn and acquired immunodeficiencies” at the Translational Immunology Research Program at University of Helsinki, Faculty of Medicine invites applications for the position of
POSTDOCTORAL RESEARCHER
Our research group focuses on the human thymus which produces key immune cells, the T cells. We 1) evaluate and develop methods to better measure thymopoiesis, 2) study how thymopoiesis and the thymus itself is affected by viral infections, and 3) aim to understand how and why certain autoimmune diseases, such as myasthenia gravis, develops. We use thymic tissue samples from both immunologically healthy individuals and patients with cutting edge techniques including thymic organ cultures and different multi-dimensional single-cell methods to dissect the normal and pathological processes in the thymus. We are seeking for a motivated post-doctoral researcher to work on Research Council of Finland – funded project.
Qualifications
Applicants with a doctoral degree and strong background in immunology or other relevant life science fields who are interested in working in an inter-disciplinary environment are particularly encouraged to apply. Applicant must be able to work independently and have good communication skills in English. The chosen applicant is expected to reside in Finland while employed by the University of Helsinki.
The person we are looking for has:
effective communication and collaboration skills
proven track record in designing and executing experimental science
motivation and determination to learn (more) immunology
Furthermore, if you have experience with the topics below, we would love to hear about your
supervision experience
working with tissue samples or organoid cultures
experience in flow cytometry, single-cell omics, CRISPR-Cas or immunohistochemistry
What We Offer
The appointment will be initially for two years starting from January 2024 (possibility to start earlier or later if needed). Trial period of six months will be applied. The monthly gross salary will be appr. 3200-3600 € per month depending on the appointee’s qualifications and experience. In addition, University of Helsinki offers comprehensive services to its employees, including occupational health care and opportunities for professional development. Applicants of any gender, linguistic and cultural background or from members of minority groups are welcomed. You can read more about working at the university on our website .
We offer you on top of these benefits an opportunity to explore and learn in a team that shares a passion for immunology. The team’s well-being is top priority in our laboratory.
How To Apply
Please submit your application as a single PDF file containing your CV, a publication list where you describe your own role in the publications that you consider the most relevant for the position, and two letters of reference. The application will be submitted through the University’s electronic recruitment system by clicking “Apply now” link. Applicants who are currently employed by the University of Helsinki are requested to submit their application via the SAP Fiori portal at https://msap.sap.helsinki.fi. The deadline for applications is 30 October 2023. Applications will be considered on a rolling basis until a suitable candidate is found.
For further information on the position, please contact Eliisa Kekäläinen (eliisa.kekalainen(at) helsinki.fi).
For information on the recruitment process, please contact HR Specialist Marja Meresto (hr-ltdk (at) helsinki.fi).
Selected publications from Kekäläinen lab:
Hetemäki I, Kaustio M, Kinnunen M, Heikkilä N, Keskitalo S, Nowlan K, Miettinen S, Sarkkinen J, Glumoff V, Andersson N, Kettunen K, Vanhanen R, Nurmi K, Eklund KK, Dunkel J, Mäyränpää MI, Schlums H, Arstila TP, Kisand K, Bryceson YT, Peterson P, Otava U, Syrjänen J, Saarela J, Varjosalo M, Kekäläinen E. Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells. Sci Immunol. 2021 Nov 26;6(65):eabe3454. doi: 10.1126/sciimmunol.abe3454.
Sarkkinen J, Dunkel J, Tuulasvaara A, Huuskonen A, Atula S, Kekäläinen E, Laakso SM. Ectopic germinal centers in the thymus accurately predict prognosis of myasthenia gravis after thymectomy. Mod Pathol. 2022 Sep;35(9):1168-1174. doi: 10.1038/s41379-022-01070-2.
Kleino I, Nowlan K, Kotimaa J, Kekäläinen E. Optimising protein detection with fixable custom oligo-labelled antibodies for single-cell multi-omics approaches. Biotechnol J. 2022 Jun;17(6):e2100213. doi: 10.1002/biot.202100213.
Nguyen NA, Huang X, Cabrera LE, Pekkarinen PT, Nowlan K, Strandin T, Kantele A, Vapalahti O, Heinonen S, Kekäläinen E. A comprehensive assessment of four whole blood stabilizers for flow-cytometric analysis of leukocyte populations. Cytometry A. 2023 Apr;103(4):313-324. doi: 10.1002/cyto.a.24700. Epub 2022 Nov 1. PMID: 36279192.
Lusila P, Toivonen A, Jarva H, Vettenranta K, Lehtimäki S, Kekäläinen E. FASCIA Method in the Assessment of Lymphocyte Mitogen Responses in the Laboratory Diagnostics of Primary Immunodeficiencies. J Clin Immunol. 2023 Apr;43(3):653-661. doi: 10.1007/s10875-022-01417-z.
The Faculty of Medicine promotes high quality scientific research. It provides research-based undergraduate and postgraduate education in medicine, dentistry, psychology and logopedics, and an international Master’s Programme in Translational Medicine. It also offers psychotherapist education. In addition to its teaching and research activities, the faculty serves as a significant expert organisation in the healthcare sector and contributes to the discourse on ethics in the field. The faculty aims to be one of the best medical research faculties in the world, while reinforcing its status as a distinguished institution of multidisciplinary education in healthcare.
The Faculty of Medicine at the University of Helsinki constitutes the academic medical centre together with HUS Helsinki University Hospital and the Helsinki Institute of Life Science (HiLIFE). This medical centre has been successful in international comparisons, ranking among the top 10 medical campuses in Europe and the top 50 globally.
Research Programs Unit (RPU) of the Faculty of Medicine consolidates demonstrated research excellence, with focused research programs addressing the greatest challenges in human health.
As Technical Support Specialist, you will have a key role in supporting our Cascadion™ SM Clinical Analyzer. You will be part of the factory support team based at our Vantaa site (where we manufacture our Clinical Analyzers) and will have a chance to work work with technically advanced instruments in an innovative and international working environment. You will work as part of the onsite factory support team to service and maintain the onsite Clinical Analyzers (used by our R&D team for new product development), whilst also supporting our global team of Field Service Engineers by providing training, technical expertise and troubleshooting support.
While this role is primarily based at our Vantaa, Finland site, fairly regular international travel (up to 20% per month) may be required (when safe to do so).
We offer a fantastic range of benefits to colleagues at our Vantaa site to help you achieve a great work/life balance, including: flexi-time; generous annual leave; vouchers towards various health benefits such as gym membership; and an on-site gym. We also work hard to support our colleagues’ career ambitions, offering great training and development opportunities throughout your career. If you like the sound of that, apply now!
TasksWhat will you do?
Perform installation, repairs, preventive maintenance and troubleshooting of Cascadion™ SM Clinical Analyzers and Assays
Accurately document, analyze and report support activities
Timely handling of technical product support cases and complaint assessment
Contribute to the development and delivery of technical training programs
Actively participate in product change process, and help to develop and maintain product support documentation and processes
What’s in it for you:
Competitive salary
Annual Incentive Plan Bonus
Flexible benefits package: may include Life Assurance; various Health Benefits & Vouchers; Pension Scheme; Flexi-time & more
Excellent career progression as part of a global organization
Requirements
Who we are looking for:
A Degree in Engineering (any discipline) OR a Degree in a Life Science (PhD level preferred)
Hands-on experience of liquid chromatography and mass spectrometry (LC-MS) instrumentation, software and applications (essential)
Professional experience in servicing analytical or general laboratory instruments (gained either as an Engineer or when working as a Scientist in a lab)
Some experience in technical product support within Invitro Diagnostics industry would be an advantage (but not essential)
Experience with development of digital technical training programs, including 3D AR/VR/MR applications and solutions (preferred but not essential)
Ability and mindset to quickly diagnose and resolve technical analytical problems
Ability to work independently and prioritize workload in an effective manner
Willing and able to travel internationally; client-focused and customer centric, as duties may include service visits to customer sites
Fluent in English (essential); proficiency in Finnish, Swedish, or other European languages an advantage
Driving licence preferred (but not essential)
About us:
Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue exceeding $25 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, improving patient diagnostics and therapies or increasing productivity in their laboratories, we are here to support them.Our global team of more than 75,000 colleagues delivers an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services and Patheon.
With Thermo Fisher Scientific, it’s not just a career. It’s a chance to realise your best – professionally and personally.
The Faculty of Pharmacy at the University of Helsinki conducts research in pharmacy and provides the highest education in the field. The Faculty offers the undergraduate degrees of Bachelor of Science (Pharmacy), Master of Science (Pharmacy) and Master of Science, as well as doctoral degrees (Doctor of Philosophy (Pharmacy) and Doctor of Philosophy). Additionally, the Faculty offers specialisation studies in community pharmacy and hospital pharmacy as well as in industrial pharmacy, and actively participates in further education in the field. The Faculty also educates Swedish-speaking Master of Science (Pharmacy) graduates. The Faculty of Pharmacy has three divisions: Pharmaceutical Biosciences, Pharmacology and Pharmacotherapy, and Pharmaceutical Chemistry and Technology. Faculty staff from different study programs cooperate in the degree programmes, which are responsible for the education leading to the degree.
The Faculty of Pharmacy invites applications for the position of a
DOCTORAL RESEARCHER (Quantitative analysis of cell surface glycan engagement in nanoparticle endocytosis)
The position is a fixed term position, starting as soon as possible after the recruitment decision is made. The appointment is until 31 August 2027. The position is filled with a 6 month probationary period.
The appointment is in the Academy of Finland research project led by docent Shiqi Wang, at the Division of Pharmaceutical Chemistry and Technology. The aim of the project is to develop a new assay using bioorthogonal reactions to study the role of cell surface glycan (a major component of cell membranes) in nanoparticle internalization. The successful candidate is expected to develop, optimize and validate the assay using different nanoparticles and cells. Your work will contribute to the fundamental understanding of how nanomaterials enter cells, which is of great importance for their biomedical applications.
The duties of the doctoral researcher include conducting research in the project framework with the aim of achieving doctoral degree in accordance with the degree requirements of the University of Helsinki, supervision of undergraduate students, and other discipline-specific teaching. The teaching duties will cover a maximum of 5 % of the total working hours.
We offer
A compact research group with a supervisor who have time and interest to help you
Opportunity to obtain multidisciplinary skills in chemistry, biology and pharmaceutical sciences, including bioorthogonal chemistry, metabolic labelling and nanoparticle uptake analysis.
National and international collaboration opportunities with experts on glycomics, nanomedicine and drug delivery
We expect
MSc degree in a relevant field (preferably in chemistry or chemical biology)
Fluent communication (oral and written) skills in English
Curiosity, genuine interest in science, initiative
Ability to work both independently and in a team
Experience in practical chemical laboratory work and cell culture
We Also Appreciate Experience In
Cell imaging and flow cytometry analysis
Bioorthogonal chemistry
Nanoparticle fabrication, characterizations and functionalization
Mass spectrometry and glycomics
Immunostaining and Western Blot
The University of Helsinki welcomes applicants from a variety of genders, linguistic and cultural backgrounds, and minorities.
Right to pursue a doctoral degree
Please note that the appointee must obtain the right to pursue a doctoral degree at the Faculty of Pharmacy, University of Helsinki and approval by a suitable doctoral programme (Doctoral Programme in Drug Research – DPDR) by the end of the 6 month probationary period of the employment, unless having already existing study right. The research plan and other application material will be prepared together with the PhD supervisor(s) in the beginning of the employment period.
Salary And Benefits
The salary is based on the job requirement scheme for teaching and research staff according to the salary system of the Finnish universities. In addition, the appointee will be paid a personal salary component. Doctoral researchers start from requirement level 2. In total, the starting gross salary of a doctoral researcher is typically about 2 400 – 2 500 EUR per month, and raises gradually as the PhD work progresses.
The requirement level of a doctoral researcher is determined on the basis of progressing in the studies. Doctoral researchers advance to level 3, when they are in the midpoint of completing the work required for the doctoral degree, and eventually to level 4, when the supervisor estimates that the researcher can publicly defend the dissertation in approximately one year.
Occupational health care is provided for university employees. Read more about the employee benefits at the University of Helsinki and why University of Helsinki is an excellent choice: https://www.helsinki.fi/en/about-us/careers .
How To Apply
Please submit your application and the required attachments through the University of Helsinki Recruitment System preferably as a single PDF file.
The application should include:
a motivation letter (max 1 page) describing why you are interested in this position and how you are qualified
a detailed CV (max 2 pages) with full contact details, education/previous degrees obtained, prior work/research experience, link to the online version of the MSc/licentiate thesis (if available) and list of potential publications (if any), and contact information of one or more previous supervisors, employers, or other references/recommendations
A research proposal describing how bioorthogonal chemistry can be used to study nanoparticle-cell interactions (max 2 pages). The bibliography or reference list does not count in the page limit.
The closing date for applications is 5th October 2023 (23:59 EEST). Zoom interviews of shortlisted candidates will take place by the end of October.
Further information
Position and research project: docent Shiqi Wang, shiqi.wang(at)helsinki.fi (also a recent ERC Starting Grant receiver )
Recruitment system and applying: HR Specialist Heidi Kauppinen, heidi.m.kauppinen(at)helsinki.fi, +358504155341
Faculty of Pharmacy: https://www.helsinki.fi/en/faculty-pharmacy
Working at the University of Helsinki: https://www.helsinki.fi/en/about-us/careers
Support for international staff: https://www.helsinki.fi/en/about-us/careers/welcome and also https://ihhelsinki.fi (International House Helsinki)
Related to admissions to doctoral studies
Application process to doctoral education (including demonstration of language proficiency): https://www.helsinki.fi/en/admissions-and-education/apply-doctoral-programmes/how-apply-doctoral-education
About doctoral schools and programmes: https://www.helsinki.fi/en/admissions-and-education/apply-doctoral-programmes/doctoral-school-and-doctoral-programmes
Doctoral Programme in Drug Research (DPDR): https://www.helsinki.fi/en/admissions-and-education/apply-doctoral-programmes/doctoral-school-and-doctoral-programmes/doctoral-programmes-health-sciences/doctoral-programme-drug-research
Daiichi Sankyo is searching for a colleague with Passion for people, Innovation and compassion for Patients.
Daiichi Sankyo and its 17.000 employees in more than 20 countries are dedicated to the creation and supply of innovative pharmaceutical products. We have a 2030 Vision to become an “Innovative Global Health Care Company Contributing to the Sustainable Development of Society”. Our European headquarters are in Munich, Germany and we have affiliates in 12 European countries. The Nordic headquarter opened in November 2018 and is based in Copenhagen, Denmark. For more information: www.daiichi-sankyo.eu. We are seeking highly qualified candidates to fill the position. Medical Advisor Finland, Oncology breast cancer with a passion for cross-functional team work
The Position:
To be a Therapeutic Area Oncology Scientific Lead for Finland, responsible for discussing our products, patients’ treatment trends and studies in the therapeutic areas in which we are involved, on a peer-to-peer basis with a defined audience of leading specialists (physicians, pharmacists, hospital managers, board members of scientific societies and other stakeholders) and to be considered a trusted scientific counterpart and partner.
To maximize company product value through high scientific quality communication with leading specialists on a peer-to-peer basis. Through activities in line with the medical affairs plan, the Medical Advisor Oncology is responsible for the realization of short-term and long- term company goals.
Key Responsibilities:
Co-develop and execute an external stakeholder management plan in close collaboration and coordination with the respective cluster organization in Medical Affairs, Commercial and Market Access
Communicate the value of company products, contribute to e.g. market access activities
Through scientific interactions, champion the medical value of our products fairly based on the risk-benefit profile of our drugs and contribute to the fostering of innovative approaches
Proactive and reactive communication of medical scientific data to leading specialists and broader external healthcare related audiences
Communicate non-promotional general information about our company, including pipeline, research and development programs and other relevant information
Respond to unsolicited scientific queries from customers for approved products and products/indications in development, based on medical affairs and medical information documents
Organize and participate in medical education activities: identify/support/educate speakers
Act as a reference point for commercial and market access functions for any scientific query, in collaboration with medical information as appropriate
Support and manage medical affairs clinical activities strategy, planning, design and execution (in close cooperation with HQ and CROs)
Support the set up and follow up of registries and other non-interventional medical affairs studies, and propose investigators and sites for interventional and non- interventional medical affairs studies
Ensure a link between headquarter, local medical department and key opinion leaders
Represent Daiichi Sankyo at medical meetings, conferences, advisory boards, etc. at key institutions and in interactions with key opinion leaders
Support medical affairs activities and generation and dissemination of data supporting overall product scientific and business strategy
Assist with the scientific review, development, approval, execution and communication of affiliate medical affairs sponsored or supported clinical research activities
Visit key accounts and key opinion leaders to answer any medical/scientific questions concerning the molecule/product
Ensure budgets, timelines, compliance requirements are factored into programs’ scientific activities
Professional experience and personal skills:
Strong scientific background e.g. Medical Doctorate (M.D.) degree or PhD in medical/biological sciences or equivalent with relevant therapeutic area knowledge
·Knowledge from working in Medical Affairs is preferred but not required
Good knowledge of clinical trial methodology, regulatory requirements governing clinical trials and experience in development strategy and the design of protocols
Strong understanding of the pharmaceutical business
Proven collaborative skills in a cross-functional team environment
Ability to interact externally and internally to support the business strategy
Fluency in Finnish & English
Expected around 30 business travel days
Working in Daiichi Sankyo Nordics:
Daiichi Sankyo Nordics was established as an Oncology organization in 2018, based in Copenhagen, Denmark. We operate in all four Nordic countries: Denmark, Sweden, Norway, and Finland. As an employee with Daiichi Sankyo Nordics, you can have a huge impact on the way we work and be part of building our culture. We have a “can-do” attitude and go the extra mile to reach our goals together as a team. This sometimes means to go beyond your own role to succeed.
Our success relies on courageous people who seize opportunities and turn them into results. This is the reason why we encourage our teams – also cross Europe – to challenge conventional thinking and share their ideas for success and learnings. Through innovative thinking and honest feed-back we can learn and leverage the full potential of our company. All based on trust.
PharmaRelations is assisting in the recruitment. Please send your CV and/or application via PharmaRelations website. We are not able to handle CVs via email. We handle the applications and interviews already before the due date, hence it may be beneficial to apply early. If you have any questions, please feel free to contact Sari Reti, sari.reti@pharmarelations.fi / 040 643 2545 or Piia Rantala, piia.rantala@pharmarelations.fi/0407567664.
Research Program Unit, the Faculty of Medicine at the University of Helsinki invites applications for a fixed-term position of
LABORATORY MANAGER for Klefstöm Lab
We are a vibrant research lab of about 20 researchers, including postdocs, graduate students and highly skilled research assisting personnel. Our mission is to translate high-impact laboratory discoveries for the benefit of cancer patients. We are seeking an experienced laboratory manager, available immediately, to work at the interface of the Klefström lab and several HiLIFE research services, especially the Helsinki Virus (HelVi) core.
In Klefström lab the candidate takes care of operational lab management and maintenance tasks, but may also participate research projects by assisting in experiments. In HiLIFE HelVi the candidate will manage the recombinant virus laboratory (BVC) including tasks like BSL2 viruslab maintenance, customer service, coordination activities within HiLIFE and Biocenter Finland, biosafety training and generation of lenti- and retroviral particles for in vitro and in vivo purposes.
For more information about Klefström Lab and BVC, please visit:
We are looking for a lab manager with a higher vocational diploma or a master’s degree in molecular biology, biotechnology, engineering (Tech.) or equivalent. A successful candidate must have 3+ years of work experience in biomedical research, excellent communication skills in English, experience in cell culture and molecular and cell biology methods and competence for operational lab management.
Advantages for the position include: Previous knowledge or experience in recombinant viruses, communication skills in Finnish language, a license and previous experience in in vivo methods and BSL2 gene transfer methods. The position is 100% on-site.
What We Offer
We offer a vibrant and teamwork-spirited environment as well as a meaningful job in non-profit Academic surroundings. The position provides excellent possibilities to develop skills in wide variety of molecular and genetic techniques, high technology facility management, customer service and in assisting scientific research. You will be an essential part of a team of 20 researchers and research assisiting personnel, all with strong motivation to improve human health through cancer research. Your salary will be determined through a common YPJ salary system of Finnish Universities, which takes into account your job demand level and individual performance.
How To Apply
Applications should be submitted through the University of Helsinki Recruitment System via the ”Apply now” button. Applicants who are currently employed by the University of Helsinki are requested to submit their application via the SAP Fiori portal at https://msap.sap.helsinki.fi. The closing date for applications is 28 September but the position is filled as soon as a suitable candidate is found.
Applicants of any gender, linguistic and cultural background or from members of minority groups are welcomed. You can read more about working at the university on our website .
For further information on the position, please contact Professor Juha Klefström (klefalab-office (at) helsinki.fi).
The Faculty of Medicine promotes high quality scientific research. It provides research-based undergraduate and postgraduate education in medicine, dentistry, psychology and logopedics, and an international Master’s Programme in Translational Medicine. It also offers psychotherapist education. In addition to its teaching and research activities, the faculty serves as a significant expert organisation in the healthcare sector and contributes to the discourse on ethics in the field. The faculty aims to be one of the best medical research faculties in the world, while reinforcing its status as a distinguished institution of multidisciplinary education in healthcare.
The Faculty of Medicine at the University of Helsinki constitutes the academic medical centre together with HUS Helsinki University Hospital and the Helsinki Institute of Life Science (HiLIFE). This medical centre has been successful in international comparisons, ranking among the top 10 medical campuses in Europe and the top 50 globally.
Research Programs Unit (RPU) of the Faculty of Medicine consolidates demonstrated research excellence, with focused research programs addressing the greatest challenges in human health.