Ajankohtaista

Research assistant / laboratorioassistentti, Molecular Profiling – Orion, Turku

18.1.2019 | Avoimet työpaikat

https://duunitori.fi/tyopaikat/tyo/orion-research-assistant-laboratorioassistentti-molecular-profiling-turku-sdsuu-6913847

Työpaikkakuvaus

Meitä Orionilaisia on 3200 yli 20 maassa ja työskentelemme hyvinkin erilaisissa tehtävissä. Joukostamme löytyy niin tutkijoita ja laborantteja kuin insinöörejä ja IT-asiantuntijoitakin sekä tuotantotyöntekijöitä ja monia muita. Tarjoamme työntekijöillemme monipuolisia sekä vastuullisia tehtäviä aidosti monialaisessa ympäristössä. Kannustamme oman osaamisen kehittämiseen ja tarjoamme mahdollisuuden vaikuttaa työtehtäviin ja oman urapolun luomiseen Orionilla. Me etsimme oman alansa huipputekijöitä, jotka jakavat aidon innostuksemme siihen, mitä teemme. Tutustu Orioniin tarkemmin >>

Haemme laboratorioassistenttia määräaikaiseen työsuhteeseen Molecular Profiling -yksikköön. Molecular Profiling -yksikkö vastaa Orionilla kehitettävien pienmolekyylien ja biologisten lääkeaineiden teho-, turvallisuus-, metabolia ja formulaatioseulonnasta. 

Tehtäviisi kuuluu nisäkässoluviljelmien ylläpito, nisäkässolujen valmistelu ja maljaus seulontatesteihin, nisäkässolujen tai kudosnäytteiden altistus testattaville aineille ja testien analyysit mittalaiteilla. Tehtävään valittavan henkilön tulee myös pystyä valmistelemaan mittalaitedata ja tehdä alustava analyysi tulosten laadun tarkkailua varten. 

Tehtävässä menestyminen edellyttää käytännön kokemusta:

  • Nisäkässoluviljelystä (suspensio- sekä adherentit solut)
  • 384- ja 96-kuoppalevyillä tehtävistä in vitro seulonnoista
  • Aseptisesta työskentelystä
  • Kuoppalevylukijoiden käytöstä
  • Kokemus Hamilton nesteenkäsittelyrobottien tai vastaavan automatiikan käytöstä katsotaan eduksi
  • Lisäksi kokemus FLIPR-tetra mittalaitteen käytöstä katsotaan eduksi.

Arvostamme myös kokemusta entsymaattisista in vitro menetelmistä ja MS Office –ohjelmien, kuten Excel ja Word, hallintaa.

Lisätietoja tehtävästä saat Mikko Karjalaiselta numerosta 0104265849 seuraavina aikoina:

16.1. klo 14-15

18.1. klo 13-14

22.1. klo 13-14

25.1. klo 10-11Tehtävään valitulta henkilöltä edellytetään hyväksyttyä terveystarkastusta, joka sisältää myös huumausainetestauksen.P

A post-doctoral position in the Pravetoni lab at the University of Minnesota Medical School

9.1.2019 | Avoimet työpaikat

A post-doctoral position in the Pravetoni lab at the University of Minnesota Medical School is available immediately for individuals interested in development of immunotherapies to reduce opioid use disorders and opioid-related overdoses. Our unique multidisciplinary research program integrates rational vaccine design, immunomodulators, formulation/delivery platforms, pre-clinical models, analysis of B and T cell lymphocyte repertoire, GLP/GMP studies to support regulatory approval and clinical evaluation, and ad hoc industry collaborations.

Our team is currently planning Phase I clinical trials of vaccines targeting heroin and oxycodone. Strategies and platforms will be applied to development of vaccines or antibodies against emerging pathogens, and agents of bioterrorism or chemical warfare.

We are seeking an independent and motivated colleague interested in leading multidisciplinary projects  as well as team efforts. For our recent publications search PubMed for “Pravetoni M”. Posting can be found at:  https://hr.myu.umn.edu/jobs/ext/328252.

Postdoctoral researcher or project researcher to study new regulators of the immune system through single-cell omics in Molecular Systems Immunology Group at Turku Centre for Biotechnology

9.1.2019 | Avoimet työpaikat

Our international multidisciplinary research group (https://www.btk.fi/research/molecular-systems-immunology/) led by Academy Professor Riitta Lahesmaa is based at Turku Centre for Biotechnology (the Centre), BioCity Turku, Turku, Finland.  We are seeking for a motivated postdoctoral researcher or project researcher with possibility to continue work as a doctoral candidate.

Disorders in immune system and lymphocyte function lead to inflammatory diseases e.g. rheumatoid arthritis and Type 1 Diabetes. Project will focus on studying the molecular mechanisms underlying immune mediated diseases aiming at enabling individualized treatment in the future.

Description of recruiting organization

Molecular Systems Immunology group aims at understanding the regulation of human immune system to predict, prevent and treat immune mediated disorders. We study epigenetic and transcriptional regulation of T cells and molecular mechanisms of immune mediated diseases.

Turku Centre for Biotechnology is a joint research institute of University of Turku and Åbo Akademi University. The mission of the Centre is to promote high quality research and training. The Centre has excellent state-of-the-art technology platforms and expertise in single-cell omics, next-generation sequencing, epigenomics, proteomics, computational biology and high-end cell imaging.

Project

The project aims at understanding how novel regulators of immune system, recently discovered by our group, act on a molecular level. We will use cutting-edge single-cell omics tools, i.e. single cell sequencing and mass cytometry. We will collaborate closely with Dr. Tapio Lönnberg, an in-depth expert in single-cell omics and head of our Centre’s single-cell omics facility. Our key collaborator is Research Director  Laura Elo and her group, the Medical Bioinformatics Centre, who have developed novel tools to analyses single-cell omics data.

Qualifications, successful candidates have:

  • A relevant doctor’s degree (postdoctoral researcher) or a relevant master’s degree (project researcher) e.g. in life sciences or in biomedicine
  • High level of motivation, self-initiative and independency
  • Excellent team work and communication skills in English (both oral and written)
  • First-rate molecular and cell biology knowledge and skills
  • Strong publication record in international journals (postdoctoral researcher) at least in one of the following areas: immunology, molecular and cellular biology, autoimmunity, genetics, epigenetics.

Application

The salary is in accordance with the University salary system (for teaching and research personnel) level 5 (postdoctoral researcher) where the work specific salary component is 2 903,61 €/month or  levels 3-4 (project researcher),  where the work specific salary component is 2 209,17 – 2507,62 €/month. In addition, there is a share increase based on the personal performance, which is, at most, 50% of the base salary. The position starts at earliest on March 1st, 2019 (or as agreed). The positions are initially for two years, one optional year possible. There is a trial period of six months.

The deadline for applications is Jan 31, 2019 (23:59). A link to the electronic application system can be found from the following link: https://www.utu.fi/en/university/come-work-with-us/open-vacancies

Please include a CV, full publication list, list of selected publications and contact information for three references in your application.

For further information on the positions please contact: Prof. Riitta Lahesmaa, e-mail: riitta.lahesmaa@btk.fi  . Enquiries on the application procedure may be directed to Human Resources Specialist Paula Luoma, paula.luoma@utu.fi .

In vivo Specialist – KCT Kuopio Center for Gene and Cell Therapy, Kuopio, Finland

9.1.2019 | Avoimet työpaikat

http://www.kct.fi/join

https://www.sympahr.net/public/pq.aspx?3399407e&lang=en-US

In vivo Specialist

Kuopio Center for Gene and Cell Therapy (KCT) is a world-renowned research institute located in Kuopio, Finland. Our mission is to conduct high-level research on basic and translational fields of gene- and cell therapy. The centre’s niche is in the interface between academic, basic research and the commercial biotechnology industry. KCT provides an exciting environment for applied research, discovering, establishing and developing them through Phase I clinical trials and utilizing some of the most advanced analytical and mechanistic proof-of-principle approaches in the sector.

Now we are seeking for an efficient manager to coordinate our in vivo studies to support the development of investigational gene- and cell therapies. The successful candidate will be responsible for designing, implementing and overseeing of animal studies including pathology, histology and molecular analytics. The candidate must have a strong in vivo pharmacology experience. This person will work closely together with internal project teams and external collaborators and therefore have excellent communication skills.

Main responsibilities

  • Design and manage in vivo experiments for gene- and cell therapy pharmacodynamics, pharmacokinetic and efficacy studies.
  • Follow the field of experimental animal science and applicable technologies
  • Work in close collaboration with research teams and animal facility personnel.
  • Analyze data, interpret results and design subsequent studies.
  • Present and document research plans, results and apply for necessary project licenses and authorizations.  

Requirements:

  • MSc with several years’ experience or PhD from applicable field
  • Strong experience with in vivo animal experimental models
  • Excellent oral and written communication skills in English
  • Must be able to multitask and collaborate in multidisciplinary environment
  • Strong motivation, flexibility and ability to troubleshoot

We offer young and dynamic working environment. Possibility for career development in a growing international research center. Be part of our future success!

More information Cell Therapy Unit Director Tuija Kekarainen tel. 040-5376603, phone calls 15th Jan at 12-14 (Tuija.kekarainen@kct.fi) and HR Director Johanna Pirinen (Johanna.pirinen@kct.fi).

Scientist, Molecular and Cell Biology in Neuroscience – Novartis, Basel, CH

9.1.2019 | Avoimet työpaikat

https://www.linkedin.com/jobs/view/1034842904/?refId=ef1a77c2-0c4c-4e45-82e5-02f9cebad8bc&trk=eml-vjr-similar-job-title&midToken=AQFgumZyIt6sOQ&trkEmail=eml-email_jobs_viewed_job_reminder_01-null-47-null-null-41f64x%7Ejqo5brp5%7E6g-null-jobs%7Eview

Job Description

The Neuroscience (NS) Department at Novartis Institutes for Biomedical Research (NIBR) in Basel, Switzerland, is seeking a Scientist with Molecular and Cell Biology skills to join a lab focusing on neuroscience. The specific focus of the team is to modulate neuroinflammation to ameliorate or halt pathology in neurodegenerative diseases.

As part of a multidisciplinary, highly collaborative team, you will independently plan, execute and analyse experiments and interpret data aiming at the discovery of new therapeutic targets and drug leads. The group is using complex primary cell culture models, but also establishing cellular high and medium throughput assays to assess therapeutic efficacy of antisense oligonucleotides, antibodies or low molecular weight compounds under relevant physiological conditions.
On top of a solid neurobiological background, good knowledge of and experience with immunological methods would be an asset.

You will present data in meetings within the department and contribute to writing of research documents and publications. Furthermore, you will interact with multiple groups within our department as well as with other groups and external colleagues and have the opportunity to represent the lab in project team meetings.

Minimum Requirements

  • Master’s degree in Molecular Biology, Biochemistry, Biotechnology or another relevant Life Science discipline
  • Several years of post-graduate experience in industry or academia in drug discovery or related laboratory research
  • Proficiency in Molecular and Cell Biology techniques, comprising but not restricted to cultivation and manipulation of cell lines and primary cell cultures, biochemical assays (e.g. recombinant DNA technologies, cytokine assays, second messenger assays, ELISA, signaling assays, western blot) and high content cellular imaging technologies
  • Excellent understanding of pathway biology and experience in solving drug discovery related biological questions
  • Proven experience with complex cellular models, in particular with ES cells and or iPS cells and confocal microscopy is advantageous
  • Highly motivated team player with refined collaboration skills
  • Excellent communication and interpersonal skills
  • Fluency in English (oral/written)

Division
NIBR
Business Unit
NEUROSCIENCE
Country
Switzerland
Work Location
Basel

Company/Legal Entity

Novartis Pharma AG
Functional Area
Research & Development
Job Type
Full Time
Employment Type
Regular

Process Development Scientist for Cell Culture Development – AGC Biologics; Copenhagen, Capital Region, Denmark

9.1.2019 | Avoimet työpaikat

https://www.linkedin.com/jobs/view/1032123970/?refId=ef1a77c2-0c4c-4e45-82e5-02f9cebad8bc&trk=eml-vjr-similar-job-title&midToken=AQFgumZyIt6sOQ&trkEmail=eml-email_jobs_viewed_job_reminder_01-null-27-null-null-41f64x%7Ejqo5brp5%7E6g-null-jobs%7Eview

Would you like to participate in scientific innovation that makes a difference in patients’ lives? And do you have cell culture experience?

Then join AGC Biologics as a Scientist in Upstream Process Development and become part of an international and modern organization that delivers biopharmaceutical development and manufacturing. We get it right. On time.

The Department
The Upstream Process Development group is responsible for cell line development, cell culture process development, fermentation process development, process characterization and upstream process and technology transfers. Projects range from early pre-clinical development through all phases of clinical development all the way to commercial supply. Upstream Development is also responsible for all cGMP cell banking activities, design of platform processes and evaluation and implementation of new upstream technologies and techniques.
 
The work environment in our department is very informal. There is constant collaboration across the entire organization, and all employees have a very professional and flexible attitude towards their work.

Responsibilities and tasks
As a Scientist you will be involved in multiple upstream development projects, and participate in multi-disciplinary project teams including upstream, downstream and analytical scientists working in close collaboration with the clients’ scientific teams.
The upstream process development team is covering both microbial and a mammalian cell culture projects. Depending on the future needs and your experience and skills, you will be involved in working with cell line development, cell culture process development, optimization and manufacturing support. The process development is performed in scales from a few mL up to 100L. Development, evaluation and scale up of new process methodologies in the development laboratory are some of the responsibilities of the team.

The job includes:

  • planning and coordination of activities and experiments
  • verbal and written reporting to clients
  • strategic technology development
  • technical guidance within development and manufacturing
  • technical advice to business development


Experience and competencies
Ideally you hold a PhD in Molecular Biology, Cell Biology, Biochemistry or Biochemical Engineering. In addition, you have:

  • a minimum of 5 years of relevant experience from the industry
  • demonstrated strong expertise within developing upstream processes
  • thorough understanding of how modifications in cell culture conditions affect the quality and functional activity of proteins
  • experience in handling bioreactors; fed-batch and/or continuous cultivations
  • good interpersonal and communication skills
  • ability to handle several projects simultaneously
  • experience in planning, performing and reporting experiments
  • fluency in English, written and spoken

AGC offers
AGC offers a dynamic working place with good opportunities of working with a varied array of tasks and challenges. You will get insight into and experience with the way the various departments throughout a contract manufacturing organization interact in order to achieve success. Exciting and challenging assignments will constantly come your way, and you will to a large extent be able to plan your daily work yourself. AGC offers an informal working environment, where humor is part of the daily work life. We respect each other and our individual differences. AGC’s employees have a flexible attitude and we help each other to reach deadlines together as one team.

For further information regarding the position please contact Lena Nielsen, Director of Upstream Development, lnielsen@agcbio.com.

We will process the applications as they arrive. Therefore, please submit your application and CV as soon as possible and no later than January 15, 2019.

PhD student position in Professor Annamari Ranki’s group to study targeted treatment of autoimmune disorders (Skin and allergy hospital)

8.1.2019 | Avoimet työpaikat

PhD student position for 4 years is available in the research group led by professor Annamari Ranki to study targeted treatment of autoimmune disorders. The full-time position will start immediately. 

Our research group has facilities both at Biomedicum Helsinki and at the Department of Dermatology and allergology, Skin and allergy hospital, Helsinki University Hospital (https://www.helsinki.fi/en/faculty-of-medicine/departments-of-dermatology-allergology-and-venereology ).

Our  group is funded by the Academy of Finland, Cancer Foundation Finland and Helsinki University Hospital Research Funds. We are part of the Medical Faculty’s Translational Immunology Research Programme as well as participate in multiple collaborations within and outside of Finland. 

We are seeking dedicated and enthusiastic candidates with a Master’s degree in cell/molecular biology, developmental biology, bioengineering, biomedicine, or other appropriate field. The applicant should have practical experience of standard cell biology techniques. Previous experience in molecular biology and gene expression analysis is considered an advantage. We also expect good communication skills (both Finnish and English) and ability to interact efficiently in a team. 

Our overall goal is to define and develop a curative cell-based treatment for the severe multi-organ genetic disease autoimmune-polyendocrinopathy-candidiasis- ectodermal dystrophy. APECED is caused by loss-of-function mutations in the AIRE gene which is the master regulator of immune tolerance, operating both in the thymus and in peripheral lymphoid organs. We currently work with iPSCs derived from APECED patients, correct the mutated gene by lentiviral introduction and in collaboration with international partners aim to redifferentiate the gene-corrected cells to the phenotypes that normally express AIRE. The efficiency and engrafting potential of the gene-corrected cells will be tested in vivo in animal models. 

We will offer a competitive salary based on previous qualifications, experience and personal performance in the position according to University pay-scale. A six-month trial period will be applied.


We  use a wide range of molecular, cellular, and imaging techniques and thus offer a multidisciplinary,  international and inspiring research environment with access to state-of-the art technologies. 

For informal inquiries, please, contact Annika.Hau@helsinki.fi

The deadline for submitting applications is January 28th, 2019, but review of applications will begin immediately and continue until the position is filled.

Send the application to: Annamari.Ranki@hus.fi  

The application should include the following documents, either in Finnish or in English

1. A motivation letter describing your research interests (max 1 page) 

2. Curriculum vitae and qualifications

3. A complete list of publications.

4. Contact details for two reference persons.

Postdoctoral position available at the North Carolina State University (research in electrochemistry and neuroscience)

8.1.2019 | Avoimet työpaikat

A postdoctoral position is currently available in Leslie Sombers’ Lab at NCSU (https://www.somberslab.org/) on projects related to monitoring endogenous opioid neuropeptides in live brain tissue using fast-scan cyclic voltammetry, microdialysis, and HPLC-MS.

The project(s) will integrate multidisciplinary approaches including electrochemistry, optogenetic and chemogenetic manipulation, and behavioral analyses.

More information at https://jobs.ncsu.edu/postings/111252

For further information contact Leslie Sombers via email at leslie_sombers@ncsu.edu

A postdoctoral position in neuroscience is available immediately at the Virginia Commonwealth University (VCU) School of Medicine in the lab

8.1.2019 | Avoimet työpaikat

A postdoctoral position in neuroscience is available immediately at the Virginia Commonwealth University (VCU) School of Medicine in the laboratory of Kurt F. Hauser.  The candidate will study fundamental mechanisms underlying glial dysfunction and synaptodendritic injury in the striatum and hippocampus following opioid and HIV exposure.

The candidate will have the opportunity to integrate basic cellular and molecular approaches aimed at elucidating how opioid abuse exacerbates glial dysfunction and synaptodendritic injury in neuro-acquired immunodeficiency syndrome (neuroAIDS). The candidate will join a team that utilizes multi-disciplinary cell signaling, pharmacological, immunological, neurophysiological (including optogenetics), and behavioral strategies to explore opioid-HIV interactions in murine (in vitro and in vivo) and human (in vitro) models.  Cutting-edge imaging facilities, which include structured illumination and multiphoton microscopy are available.  A Ph.D., M.D. and/or equivalent doctoral degree with experience in cellular and molecular neuroscience or neuropharmacology is essential.  Additional experience in neurophysiology and/or optical physiology (genetically-encoded voltage and calcium indicators) is highly desirable.  The candidate will be provided with significant training in those disciplines with which they are less familiar, as well as significant mentoring to facilitate their transition to an independent research career.

Interested individuals are encouraged to forward a curriculum vitae, a list of three references, and a statement of research interests and career goals to Kurt F. Hauser, Department of Pharmacology & Toxicology, Institute for Drug & Alcohol Studies, VCU School of Medicine, Molecular Medicine Research Building, 1220 E. Broad St., Richmond, VA 23298 (email: kurt.hauser@vcuhealth.org).

OPEN POSTDOCTORAL / PROJECT RESEARCHER POSITION IN BIOSTATISTICS: Come work with us at Turku Centre for Biotechnology!

8.1.2019 | Avoimet työpaikat

We are looking for a postdoc or project researcher in Biostatistics as part of our multidisciplinary and international team of experts in the Computational Biomedicine group at the Medical Bioinformatics Centre, Turku Centre for Biotechnology.

The applications should be submitted at the latest on 4.2.2019 using the electronic system. The application should include a motivation letter, CV, list of publications, contact information for 3 referees, and copies of relevant degree certificates. A link to the electronic application system can be found at https://www.utu.fi/en/university/come-work-with-us/open-vacancies ID 6697. 

For further information please contact bioinformatics-coordinator@utu.fi or +358 (0)29 450 3796.