Ajankohtaista

Yhdeksän tutkijan toimea haettavina – Suomen Syöpäinstituutti

11.9.2019 | Avoimet työpaikat

Suomen Syöpäinstituutin Säätiö • Stiftelsen för Finlands Cancerinstitut, Foundation for the Finnish Cancer Institute

The Finnish Cancer Institute invites applications for nine research positions to carry out high level epidemiological, clinical, or experimental cancer research. Our aim is to contribute to high quality cancer research in Finland by providing attractive research positions enabling full focusing on an exciting topic for a fixed duration.

Research Professor, EUR 6,500 a month;

3-or 5-year positions commencing on 1 January 2020 at the earliest; aiming to enable cancer researchers to fully focus on a significant independent research topic building on applicant’s recent accomplishments as described in the research plan

  • K. ALBIN JOHANSSON RESEARCH PROFESSOR, a 5-year professorship (one post)
  • FICAN RESEARCH PROFESSOR, a3-year professorship (two posts )

Cancer Research Fellow, EUR 5,000 month;

3-year positions commencing on 1 November 2019 at the earliest; Aiming to support early-stage independent cancer researchers as evidenced by accomplishments corresponding to a docent and demonstration of an independent line of investigation in the proposal;

  • K. ALBIN JOHANSSON CANCER RESEARCH FELLOW (three posts)

Postdoctoral Cancer Researcher, EUR 3,500 month;

2-year positions commencing on 1 November 2019 at the earliest; aiming to support exciting and timely post-doctoral research in a high quality environment;

  • K. ALBIN JOHANSSON CANCER RESEARCHER (one post)
  • FICAN CANCER RESEARCHER (two posts)

Instructions for applications.

Eligible applicants include cancer researchers with recent interesting observations and an exciting plan mostly in Finland for the duration of the position. The applications in English are to contain the following three parts not exceeding 9 pages:

  • Cover & short CV not exceeding two pages with the following parts: i) Applicant’s name, current job (and its duration if fixed-term), affiliation & contact information; ii) short (max 200 words) motivation to apply for the FCI position; iii) short CV information taking note not to exceed 2 pages for this part as a whole
  • Research plan for the duration of the applied position not exceeding 5 pages including relevant permits and an estimated budget at the end with existing or anticipated other funding sources (for PI salary or for other parts)
  • A list of not more than 20 publications including number of citations received and a comment on the journal for at least recent publications. The comment can be the rank of the journal in a specified field or e.g. impact factor. This part is not to exceed 2 pages.

Applications are submitted as a single PDF file by email to FCI Secretary-General Tuula Helander firstname.lastname@helsinki.fi. Deadline for submissions: September 12, 3 pm (EET). The e-mail subject line and the PDF attachment both are named with applicant’s surname and the post (surname_Professor/Fellow/Postdoc)

Evaluation and decisions:

Applications are evaluated according to scientific quality and potential impact based on both plans and recen ttrack record and according to career stage. Decisions are made by the FCI Board based on evaluation by the Scientific Advisory Board (postdocs and fellows) or following shortlisting of research professor applicants by the Scientific Advisory Board and international expert evaluation and ranking. Decisions are expected in October (postdocs and fellows) and December (research professors) at which time all applicants are informed. The FCI positions can be renewed at most once

Further information & submission of applications by September 12, 3 pm EET:

FCI Secretary-General Tuula Helander, email: firstname.lastname@helsinki.f

Early Stage Researcher (PhD Student), the biophysical and biological correlates of pain and dysfunction in osteoarthritis – Institute of Biomedicine, University of Eastern Finland

29.8.2019 | Avoimet työpaikat

https://rekry.saima.fi/certiahome/open_job_view.html?id=00007735&did=5600&lang=fi&jc=16&nav_from_open_jobs_view_new=true

The University of Eastern Finland, UEF, is one of the largest multidisciplinary universities in Finland. We offer education in nearly one hundred major subjects, and are home to approximately 15,500 students and 2,500 members of staff. We operate in Joensuu and Kuopio. In international rankings, we are ranked among the leading universities in the world.

The Faculty of Health Sciences operates at the Kuopio Campus of the University of Eastern Finland. The Faculty offers education in medicine, dentistry, nutrition and pharmacy, as well as in some other central fields of the health care sector. The Faculty is research-intensive, and its internationally recognised research activities are closely linked to the strategic research areas of the University. There are approximately 2 500 degree students and about 450 PhD students in the Faculty. The faculty has 680 staff members. http://www.uef.fi/en/ttdk/etusivu 

We are now inviting applications for

an Early Stage Researcher (PhD student) in cell biology/translational medicine, position, School of Medicine, Institute of biomedicine, Kuopio Campus http://www.uef.fi/en/biomedicineAn Academy of Finland funded position is available in the laboratory of Professor Petteri Nieminen. http://www.uef.fi/en/biomedicine/petteri-nieminen-group. The research project is a part of the Biology and Physics of Pain in Knee Osteoarthritis (BP-PAIN) Consortium that aims to study in detail the biophysical and biological correlates of pain and dysfunction in osteoarthritis. The project employs multi-disciplinary approaches including cell cultures, high-content cellular imaging and metabolomics, as well as gene expression studies, medical imaging and neurophysiological analyses.   

We are seeking a highly motivated candidate with experience in cell cultures, biochemical analyses, molecular biology and data processing. The position aims at the PhD student completing a PhD degree within four years and enables the PhD student to take part in supervising MSc students, scientific writing, grant applications, scientific collaborations and teaching in suitable areas. Good communication and writing skills in English are required.

A person to be appointed as an early stage researcher shall be qualified to pursue postgraduate studies, i.e. he or she is required to have completed a suitable higher university degree or an equivalent education abroad which in the country in question would qualify the person for similar academic studies. Positions of early stage researchers shall always be filled for a fixed term (UEF University Regulations, Section 31).

The position is initially filled for a fixed-term of four years. The full-time position will start in November 2019, or later by agreement.

The salary of the position is determined in accordance with the salary system of Finnish universities and is based on levels 2-4 of the job requirement level chart for teaching and research staff (€2,033.29 – 2,535.20/month). In addition to the job requirement component, the salary includes a personal performance component, which may be a maximum of 50 % of the job requirement component.

For further information on the position, please contact Professor Petteri Nieminen, email:  petteri.nieminen@uef.fi, phone +358 29 4454248. For further information on the application procedure, please contact HR Secretary Tellervo Rajanto, email: tellervo.rajanto@uef.fi, phone +358 29 4454278. 

A probationary period is applied to all new members of the staff.

The electronic application should contain the following appendices:
a résumé or CV
– a list of publications 
– copies of the applicant’s academic degree certificates/ diplomas, and copies of certificates / diplomas relating to the applicant’s language proficiency, if not indicated in the academic degree certificates/diplomas
– motivation letter

The application needs to be submitted no later than 9.9.2019 (by 24.00 hours Finnish time) by using the electronic application form.

POSTDOCTORAL RESEARCHER – The research group of Prof. Kirsi Pietiläinen at the Obesity Research Unit, University of Helsinki

15.8.2019 | Avoimet työpaikat

The research group of Prof. Kirsi Pietiläinen at the Obesity Research Unit, University of Helsinki, located at Biomedicum Helsinki, is looking for a Postdoctoral Scientist.

The translational lab Pietiläinen is focused on global metabolic profiling of obesity by systems biology methods, transcriptomics, proteomics, metabolomics and epigenomics, especially concentrating on mitochondrial function in obesity in adipose tissue and muscle. The clinical studies and sample collections include twin studies and weight loss interventions. The group is part of the Center of Excellence for Research on Mitochondria, Metabolism and Disease (FinMIT) http://www.fin-mit.fi/en/ .

Pietiläinen group invites applications for a position of

POSTDOCTORAL RESEARCHER

beginning from 1.10.2019 till 31.12.2020.

Your Tasks

·         developing an advanced computational framework for comprehensive multiomics (transcriptomics, metabolomics, proteomics, lipidomics, microbiota), multitissue (adipose tissue, muscle, serum, urine, faeces, saliva) analyses

·         designing single cell RNA sequencing analytics

·         exploiting innovative concepts for data visualization 

·         developing machine learning methods, especially for predicting longitudinal models 

·         active participation in research projects 

·         writing of manuscripts and project proposals 

·         participation in mentoring of students 

You have

·         PhD degree in Bioinformatics, Computational Biology, Computer Science or a related Life Science discipline (with strong background in Bioinformatics) 

·         advanced programming skills

·         strong background in statistical methods 

·         experience in the analysis of large-scale omics data

·         excellent communication, writing, and organizational skills 

·         strong interpersonal skills with the ability to build scientific relationships.

·         highly self-motivated and enthusiastic for cross-scaling omics research 

We Offer

·         an interdisciplinary and supportive team 

·         a lab with excellent multiomics, multitissue human materials 

·         innovative projects in mitochondrial metabolism and obesity

·         an excellent scientific environment in an international research community 

Your application should include a CV, publication list, motivation letter and contact details for referees (referee letters are considered a surplus).

Salary will be based on the Universities salary scheme for teaching and research personnel composed of both task specific (demand level 5) and personal performance components. Trial period will be applied.

Please submit your application to professor Kirsi Pietiläinen: kirsi.pietilainen@helsinki.fi , tel. +358505992295 by 30.8.2019.

Senior Scientist/Post-doctoral researcher Immunology-oncology, Cell biology – Kuopio Center for Gene and Cell Therapy (KCT)

15.8.2019 | Avoimet työpaikat

https://www.sympahr.net/public/pq.aspx?3916f124&lang=en-US

Kuopio Center for Gene and Cell Therapy (KCT) is a modern research institute located in Kuopio, Finland. Our mission is to conduct high-level research on basic and translational fields of gene- and cell therapy. The centre’s niche is in the interface between academic, basic research and the commercial biotechnology industry. KCT provides an exciting environment for applied research and discovery, developing therapeutic products through Phase I clinical trials and utilizing some of the most advanced analytical and mechanistic proof-of-principle approaches in the sector. Opportunities for two highly motivated Senior Scientists have now opened at the KCT Immunotherapy Program to work in projects that revolve around cancer and immune cell genetic engineering. Both projects are already active in KCT and involve clinicians, academic teams and international collaborators.

Project 1. In this project, the successful candidate will be developing T and NK based cell therapy products for ovarian and brain cancers. Lentivirus technology and CRIPR-Cas will be utilized in genetic engineering of the cells for cancer targeting and improved performance in solid cancer treatments. The candidate will closely work together with KCT team developing clinical grade cell therapy product processes. KCT research team has already established in vitro and in vivo methods to further characterize and functionally test the developed products.

Project 2. In this project, the successful candidate will participate in establishing 3-D cultures and characterization of ovarian and brain tumors. Cell culture, immunological and molecular methods are extensively utilized. The candidate will also participate in single-cell sequencing and proteomics characterizations involving collaborative laboratories specialist in these techniques. The candidate will work together with KCT research team with extensive knowledge in cell biology, immunology and bioinformatics.

The successful candidates will be responsible for designing, implementing and overseeing the project. These duties will involve practical laboratory technologies, and therefore strong wet lab background is essential. This person will work closely together with internal project teams and external collaborators and therefore have excellent communication skills in English.

Education:

  • The successful applicant should hold or be about to obtain a PhD in a relevant field, such as cell biology, immunology, immuno-oncology or cancer biology.

Skills and experience in the following areas is highly desirable:

  •          Project management
  •          Strong overall wet lab experience
  •          Cell biology methods, like primary cell isolation, 3D organoid culture, functional assays
  •          Multicolor flow cytometry – panel design and data analysis
  •          Gene editing technologies and advanced molecular methods
  •          Setting up and developing functional assays and analytical methods
  •      Furthermore, extensive understanding of such or related concepts as the human immune system activation and regulation or cancer immunosurveillance and cancer therapy is considered beneficial
  •          Excellent teamwork and communication skills in English are essential

Main responsibilities:

  •          Both job opportunities are Senior Scientist positions

The positions are initially for three years. International candidates are strongly encouraged to apply. KCT’s HR team are available to help with issues related to relocation.

Sent your cover letter and CV latest 22nd September 2019.

Further information (fistname.lastname@kct.fi):

Tuija Kekarainen, Cell Therapy Unit Director

Anssi Kailaanmäki, Head of Immunology

Katja Puttonen, Head of Process Development

Johanna Pirinen, HR Director

Senior lecturer position at Uppsala University, Experimental structural biology

14.8.2019 | Avoimet työpaikat

http://www.uu.se/jobb/detaljsida/?positionId=279114

Uppsala universitet är ett brett forskningsuniversitet med stark internationell ställning. Uppgiften är att bedriva forskning och utbildning av högsta kvalitet och att på olika sätt samverka med samhället. Vår viktigaste tillgång är alla de individer som med sin nyfikenhet och sitt engagemang gör Uppsala universitet till en av landets mest spännande arbetsplatser. Uppsala universitet har 44.000 studenter, 7.100 anställda och en omsättning på 7 miljarder kronor.

Institutionen för cell- och molekylärbiologi (ICM) (http://www.icm.uu.se)  är en av de mest internationella, interdisciplinära och framstående forskningsinstitutionerna inom molekylär biovetenskap i Europa. Forskningsområden vid institutionen spänner från genetik till biofysik. 

Den utlysta anställningen är placerad vid programmet för strukturbiologi (http://www.icm.uu.se/strukturbiologi). Forskningen vid programmet är inriktad på att med hjälp av struktur- och funktionsstudier få djup mekanistisk insikt i biologiska processer. Vi studerar idag ett brett spektrum av centrala biologiska processer alltifrån proteinevolution, proteinsyntes, och proteinveckning och assembly, till metallhomeostas, enzymkatalys och antibiotikaresistens. Vi söker nu en universitetslektor som kan komplettera och bredda både kompetens och forskningsinriktning vid programmet. 

Beskrivning av ämnesområdet: Ämnesområdet är biologiska makromolekylers struktur och funktion. 

Arbetsuppgifter: Undervisning, forskning och administration inom experimentell strukturbiologi. Undervisning på grundläggande och avancerad nivå inom cell- och molekylärbiologi med huvudsaklig inriktning mot strukturbiologi. Till undervisning räknas kursansvar och kursadministration samt handledning av mastersstudenter och doktorander. I arbetsuppgifterna ingår att vid behov utföra administrativa arbetsuppgifter relevanta för institution och fakultet. Det ingår även att följa utvecklingen inom det egna ämnesområdet och samhällsutvecklingen i övrigt som har betydelse för arbetet vid universitetet. I arbetsuppgifterna ingår även att leda utveckling och översyn av den planerade lokala kryo-EM faciliteten och därmed sammanhängande informations- och utbildningsaktiviteter. 

Behörighetskrav: Behörig att anställas som universitetslektor är enligt högskoleförordningen den som dels visat pedagogisk skicklighet och dels har avlagt doktorsexamen eller har motsvarande vetenskapliga kompetens eller har någon annan yrkesskicklighet. Det krävs att den pedagogiska skickligheten, den vetenskapliga kompetensen och yrkesskickligheten är relevant för anställningens ämnesinnehåll och de arbetsuppgifter som ska ingå i anställningen. 

Enligt Uppsala universitets anställningsordning gäller som behörighetskrav för anställning som universitetslektor att ha genomgått för verksamhet inom universitetet relevant pedagogisk utbildning, omfattande tio veckor, eller förvärvat motsvarande kunskaper. Om det föreligger särskilda skäl kan den högskolepedagogiska utbildningen genomföras under de första två anställningsåren. Enligt Uppsala universitets anställningsordning gäller vidare som allmänt behörighetskrav för lärare att ha de personliga egenskaper som krävs för att fullgöra anställningen väl. 

Den sökande ska ha dokumenterad förmåga att undervisa på svenska och/eller engelska om inte särskilda skäl föreligger. Innehavaren förväntas kunna undervisa på svenska inom två år. 

Den som erbjuds en anställning som universitetslektor kan befordras till professor om den sökande har begärt det, är behörig för en sådan anställning och dessutom bedömts lämplig utifrån de specifika kriterier som fastställts av fakultetsnämnden. 

Bedömningsgrunder

Vetenskaplig och pedagogisk skicklighet: Vid urval bland behöriga sökande kommer vikt att fästas främst vid såväl vetenskaplig som pedagogisk skicklighet varvid särskild vikt kommer att fästas vid den vetenskapliga skickligheten. Vetenskaplig skicklighet avser forskningsmeritering, även forskningsmeritering från arbetslivet, som inbegriper till exempel teknikutveckling och innovationsförmåga. Vid bedömning av den vetenskapliga skickligheten kommer särskild vikt att läggas vid erfarenhet av strukturbestämning med högupplöst elektronmikroskopi. 

Vid bedömning av den vetenskapliga skickligheten kommer i första hand vetenskaplig kvalitet att beaktas. Även forskningens omfattning, främst djup och bredd, kommer att tillmätas betydelse. Förmåga att planera, initiera, leda och utveckla forskning och utbildning på forskarnivå, förmåga att i konkurrens erhålla medel för forskning, liksom visad förmåga till interaktion både inomvetenskapligt och med det omgivande samhället kommer också att tillmätas betydelse. 

Lika stor omsorg kommer att ägnas prövningen av den pedagogiska skickligheten som den vetenskapliga skickligheten. Pedagogisk skicklighet avser utbildnings- och undervisnings­meritering. Den pedagogiska skickligheten kan ha uppnåtts i yrkeslivet genom handledning, internutbildning, mentorsprogram etc. 

Vid bedömning av den pedagogiska skickligheten kommer i första hand pedagogisk kvalitet att beaktas. Även omfattning, såväl bredd som djup, kommer att tillmätas betydelse. Vidare kommer förmåga att planera, initiera, leda och utveckla utbildning och undervisning, liksom förmåga att forskningsanknyta undervisningen sett utifrån forskning i det aktuella ämnet, ämnesdidaktik och högskolepedagogik att tillmätas betydelse. Även förmåga till interaktion om högskolepedagogiska frågor med aktörer inom och utom universitetet ingår i den pedagogiska skickligheten. Vid bedömning av den pedagogiska skickligheten kommer särskild vikt att läggas vid pedagogiska meriter inom ämnesområdena cellbiologi, molekylärbiologi, biokemi och strukturbiologi. 

Samtliga meriter ska vara dokumenterade så att både kvalitet och omfattning kan bedömas. 

Universitetet kommer i denna rekrytering främst att beakta den som efter en kvalitativ helhetsbedömning av kompetens och skicklighet bedöms ha de bästa förutsättningarna att genomföra och utveckla aktuella arbetsuppgifter samt bidra till en positiv utveckling av verksamheten. 

Föräldraledighet, deltidsarbete på grund av vård av barn, fackligt uppdrag, militärtjänst eller liknande beaktas som arbetslivserfarenhet och bör anges i meritförteckningen.

Uppsala universitet värdesätter de kvaliteter som jämn könsfördelning och mångfald tillför verksamheten. Vi ser därför gärna sökande av alla kön och med olika födelsebakgrund, funktionalitet och livserfarenhet.

Lön: Individuell lönesättning tillämpas.

Tillträde: Efter överenskommelse.

Anställningsform: Tillsvidareanställning.

Anställningens omfattning: 100%

Upplysningar om anställningen lämnas av professor David van der Spoel, tel. 018-471 4205, e-post david.vanderspoel@icm.uu.se eller professor Stefan Knight, tel. 018-471 4554, e-post stefan.knight@icm.uu.se.

För ytterligare information se universitetets anställningsordning och fakultetens riktlinjer för anställning.

Välkommen med din ansökan senast den 31 augusti 2019, UFV-PA 2019/1556.

Vi undanber oss erbjudanden om rekryterings- och annonseringshjälp. Ansökan tas emot i Uppsala universitets rekryteringssystem.

Placering: Uppsala universitet, Institutionen för cell- och molekylärbiologi

Anställningsform: Heltid , Tillsvidareanställning

Lön: Fast lön

Antal lediga befattningar: 1

Sysselsättningsgrad: 100%

Ort: Uppsala

Län: Uppsala län

Land: Sverige

Facklig företrädare: Seko Universitetsklubben seko@uadm.uu.se
ST/TCO tco@fackorg.uu.se
Saco-rådet saco@uadm.uu.se

Referensnummer: UFV-PA 2019/1556

Sista dag för ansökan: 2019-08-31

Postdoctoral Fellow position available in the Department of Neuroscience at the Medical University of South Carolina

14.8.2019 | Avoimet työpaikat

Postdoctoral Fellow position available on a NIDA T32 training grant to pursue a collaborative study in the laboratories of Dr. Jacqueline McGinty and members of the Addiction Research Center in the Department of Neuroscience at the Medical University of South Carolina (https://education.musc.edu/MUSCApps/facultydirectory/Mcginty-Jacqueline )

The primary goal of the study is to characterize the role of pathway-specific neurons originating in the prefrontal cortex of rodents during and after drug (cocaine, heroin) self-administration using viral –mediated DREADD expression, in vivo electrophysiology, calcium imaging, and dendritic spine analyses. The next stage of research is to determine if normalizing the proteins and physiological processes affected by addictive drugs during early abstinence can prevent subsequent relapse.

Contact information:

Jacqueline F. McGinty, Ph.D.

Professor, Dept of Neuroscience

Director, MUSC Brain Research Institute


Medical University of South Carolina
email mcginty@musc.edu

Salary commensurate with NIH guidelines. Must be a US citizen or resident (green card) to be eligible for a NIH T32 position.

Open position for a Senior Researcher (Post-doctoral fellow) in Thyroid Research at the Institute of Biomedicine, University of Turku

13.8.2019 | Avoimet työpaikat

A post-doctoral job is available at the Research Centre for Integrative Physiology and Pharmacology, in docent Jukka Kero´s Thyroid group at the Institute of Biomedicine, University of Turku, Finland. The Department is well equipped with facilities for modern molecular and cell biology research. The close connection with Turku Center for Disease Modeling (TCDM) offers excellent facilities and infrastructure to perform experiments with genetically modified disease models. We are looking for a highly motivated senior researcher or a postdoc with strong experience in molecular biology, genetics and experimental disease models. The group focuses on molecular mechanisms of thyroid disorders. We are studying thyroid genetics in patients with congenital or hereditary thyroid diseases via in silico, in vitro methods, or genetically modified disease models.

The research project focuses on novel gene mutations and testing their pathogenicity in vitro and in vivo. The work involves analyzing next-generation sequencing data and generation and phenotyping of new disease models. The researcher will closely work with technicians and PhD-students in the group.

There is a trial period of four months. The position is planned for 2-4 years and could start in autumn 2019 or as negotiated.

The informal application should include CV,motivation letter (max one page),and recommendation letter.

For further information about the position, please contact docent Jukka Kero (jukka.kero(at)utu.fi)

Postdoctoral Positions in Chemical Neurobiology and Neuropeptide Physiology in the Banghart Laboratory, Neurobiology Section at the University of California San Diego

13.8.2019 | Avoimet työpaikat

The Banghart Lab at UCSD seeks to fill two NIH-funded Postdoctoral Fellowship positions to study neuropeptide signaling in the mammalian brain. Fellows will contribute to team-based, multi-institutional molecular tool-development efforts in addition to pursuing independent research projects. Technologies under development include photoactivatable neuropeptides, precision pharmacological reagents, and neuropeptide sensors. Our physiological studies aim to understand the role of several neuropeptides in pain modulation, and molecular mechanisms that govern neuropeptide secretion in the brain. This work is funded by the NIH Brain Initiative, NIDA and NIGMS.

The Chemistry position requires expertise in synthetic organic chemistry and the ability to independently plan and carry out the synthesis and analysis of new molecules. Some experience with peptide chemistry and/or light-sensitive molecules is highly desired. Candidates should be highly independent in the hood and comfortable being surrounded by neurobiologists. Interest in contributing to biological evaluation of new probes is a plus. Applicants should hold a Ph.D. or equivalent degree in chemistry or chemical biology.

The Neurobiology position requires experience in molecular biology, cell culture and fluorescence microscopy. Additional experience with G-protein coupled receptors, intracellular signaling, electrophysiology, rodent behavior, and/or stereotactic surgery is highly desirable. Candidates must be willing to work as part of a team to contribute to collaborative tool-development projects while also pursuing an additional independent research project that exploits the resulting technologies. Applicants should hold a Ph.D. or equivalent degree in biology, pharmacology, neuroscience or related fields.

The Banghart Lab is located in the Center for Neural Circuits and Behavior (CNCB), which is the hub of UCSD Neuroscience community. We are proud to work in a highly interactive research environment that embraces diversity and work-life balance in addition to scientific excellence. Both positions will offer opportunities to write grants, train students and present findings at professional conferences. Salary will be a minimum of $50,760 according to UCSD guidelines.

Candidates should send their CV and the names of 3 references to mbanghart@ucsd.edu

www.banghartlab.org

https://postdoc.ucsd.edu/
https://pda.ucsd.edu/

Open position for a Postdoctoral Researcher in Statistical / Computational Genomics at the Centre of Excellence in Complex Disease Genetics, Insitute for Molecular Medicine Finland FIMM

13.8.2019 | Avoimet työpaikat

FIMM is currently seeking

Postdoctoral Researcher in Statistical / Computational Genomics at the Centre of Excellence in Complex Disease Genetics

for a fixed-term of two years with a possibility of extension for a third year

Description:

Revealing the molecular mechanisms underlying common complex diseases holds the promise of improved and targeted prediction, prevention, diagnosis and treatment. Building on unique resources and an extensive track record in disease genetic studies in Finland, the Academy of Finland Centre of Excellence in Complex Disease Genetics (CoECDG), hosted at the Institute for Molecular Medicine Finland (FIMM) at HiLIFE and the Faculty of Medicine, develops and applies a powerful and general strategy for comprehensive identification of risk and protective variants and leads national efforts to implement genomic findings into prevention and personalised treatment of common complex diseases.

The CoECDG is searching for outstanding postdoctoral candidates to work with data-driven computational projects related to the CoE focus areas:

1) Tools for prediction and prevention of complex diseases
2) Tools for personalised management of complex diseases
3) Role of genetics in pathways through major life-course health events

Apply at the latest on August 16th 2019.

For further information about the position, please visit our website or our research group websites or contact Assist. Prof. Matti Pirinen (matti.pirinen(at)helsinki.fi). For the potential correspondence, please use the following topic in your subject field “CoECDG OPEN POSTDOC POSITION”.

https://www.fimm.fi/en/open-position/postdoc-statistical-computational-genomics
https://www.helsinki.fi/en/researchgroups/centre-of-excellence-in-complex-disease-genetics/open-positions

PhD student position – Laboratory of Stem Cells and Cancer, Université Libre de Bruxelles

9.8.2019 | Avoimet työpaikat

Laboratory of Stem Cells and Cancer‐ Université Libre de Bruxelles
http://blanpainlab.ulb.ac.be/

PhD student position
4 years grant (2 years renewable), starting October 2019


Our laboratory is located on the medical campus (Erasme) of Université Libre de Bruxelles (Belgium) and is headed by Prof. Cédric Blanpain. This project will be performed under supervision of Dr. Alexandra Van Keymeulen and in close collaboration with Dr.Christel Pequeux at Université de Liege.


Research Project
Approximatively 75% of breast cancers are estrogen dependent and estrogen receptor‐positive (ER+). Despite the large efficacy of anti‐estrogen treatments, relapse occurs in 30% of cases. In addition, estrogens remain the most powerful treatment to circumvent menopause symptoms. However, their use as menopause hormone treatment (MHT) remains controversial since MHT is associated to an increased risk of breast cancer. A better understanding of the ER signaling upon estrogen or anti‐estrogen treatment in mammary gland and during breast tumorigenesis is thus crucial to develop new tools to target these cancers and to develop a new generation of MHT.


In this context, we aim at answering the following questions:
Aim 1: What is the impact of estrogen signaling on the transcriptional and chromatin landscapes of
the ER+ and ER‐ epithelial cells during tumorigenesis?
Aim 2: Which mechanisms are promoting breast cancer upon MHT treatment during menopause?
Aim 3: How come estetrol treatment during menopause does not promote breast cancer, while it prevents side effects of menopause?


These experiments will constitute a novel and comprehensive definition of the transcriptional and chromatin landscapes of purified individual cell lineages during tumorigenesis and upon MHT. Our results will constitute the basis to highlight new potential targets to treat luminal‐like breast cancer and will also provide precious information to assess how estetrol could safely replace estradiol use as MHT, without increasing breast cancer risk. Finally, they will open new avenues to prevent hormone‐dependent tumorigenesis.


Methods: in vivo models of mammary gland and breast cancer (MMTV‐PyMT, PDX, cell line xenografts), FACS cell sorting, RNAseq, ATACseq, Chipseq, qPCR, 3D cultures.


Skills: Master degree in Biomedical science, molecular biology, biochemistry or equivalent, FELASA certification. High motivation, enthusiasm and scientific curiosity are mandatory. Ability to learn fast,
to work independently, meticulous, good communication would be appreciated.

Contact: To apply, send a motivation letter, a C.V. and two references with their email address to
Alexandra Van Keymeulen (avkeymeu@ulb.ac.be)