Ajankohtaista

A postdoctoral position is available immediately in the field of cell and developmental biology at the Institute of Biotechnology, University of Helsinki

19.11.2018 | Avoimet työpaikat

Endowed Professorship in Drug Abuse Research at the Indiana University – Bloomington and The Department of Psychological and Brain Sciences

19.11.2018 | Avoimet työpaikat

Open position for a postdoctoral researcher at the Obesity Research Unit, University of Helsinki

19.11.2018 | Avoimet työpaikat
The Faculty of Medicine at the University of Helsinki conducts high-quality research and provides research-based basic and post-graduate education in medicine and dentistry, psychology and logopedics. The Faculty of Medicine at the University of Helsinki is located in the Meilahti-Ruskeasuo Campus, offering excellent opportunities for close collaboration with both the University Hospital and public sector research institutes.
 
Research Programs Unit of the Faculty of Medicine is a top-quality research environment. Unit’s five research program comprises groups that integrate clinical, translational and biomedical research. The Clinical and Molecular Metabolism program (starting 2019) brings together the best research in the field of diabetes and obesity in Finland.
 
Group Pietiläinen’s aim at the Obesity Research Unit is to identify mechanisms behind obesity-related metabolic disturbances and to study their novel treatment options. Her research is especially focused on mitochondrial function in obesity in adipose tissue and muscle, and the group is part of the Center of Excellence for Research on Mitochondria, Metabolism and Disease (FinMIT) http://www.fin-mit.fi/en/ .
 
Pietiläinen group invites applications for a position of
 
POSTDOCTORAL RESEARCHER

beginning from 1.1.2019 till 31.12.2019.
The applicant should have
o    Doctoral degree
o    Strong background in obesity and/or mitochondrial metabolism. 
o    Background in basic biology, cell cultures, preferably adipocytes and myoblasts, as well as in other laboratory techniques, especially those regarding mitochondria.
o    Background in bioinformatics or biostatistics and handling of omics datasets is of special advantage
o    Innovative and creative thinking
o    Ability to work independently
o    Outstanding written and oral English skills
Your application should include a CV, publication list, motivation letter and contact details for referees (referee letters are considered a surplus).
 
Salary will be based on the Universities salary scheme for teaching and research personnel composed of both task specific (demand level 5) and personal performance components. Trial period will be applied.
Please submit your application using the University of Helsinki Recruitment System via the link Apply for job or directly to Professor Pietiläinen, kirsi.pietilainen@helsinki.fi .
 
Further information is available from professor Kirsi Pietiläinen Principal Investigator, tel. +358505992295 or kirsi.pietilainen@helsinki.fi .

Open position for a Senior staff researcher at the CRISPR gene therapy group, Centre for Molecular Medicine Norway (NCMM)

13.11.2018 | Avoimet työpaikat
Senior staff researcher: CRISPR gene therapy group
https://www.jobbnorge.no/en/available-jobs/job/158270/senior-staff-researcher-crispr-gene-therapy-group
 
About the position
A permanent senior scientist position is available at Centre for Molecular Medicine Norway (NCMM), an EMBL partnership institute in Oslo, in the soon to start CRISPR gene therapy group led by Emma Haapaniemi, MD-PhD.

The aim of our laboratory is to build a gene editing platform that can be used to correct patient-specific mutations in ex vivo cell therapies for genetic immune and other rare childhood diseases. We will use high-throughput biology techniques to optimize, develop and understand the CRISPR-Cas system that forms the base of the platform, and develop and implement methods to evaluate its safety in a clinical setting. We will use the modified gene editing technologies for the benefit of the patients in the adjacent children’s hospital.
 
We look for an experienced scientist who has postdoctoral research experience in multiple research environments. You are detail-oriented and rigorous experimentalist who enjoys working at the bench and performing well-thought, high-quality cell biology experiments. You have a solid basic science training in biochemistry or related field, and can perform standard bioinformatics and computational biology analyses in linux environment.

Work tasks
  • Design and optimize custom Next Generation Sequencing libraries
  • Design and conduct customized CRISPR screening experiments
  • Supervise graduate students, postdoctoral fellows and technicians in designing and conducting molecular biology experiments.
  • Perform standard wetlab molecular biology experiments
Qualification requirements
  • PhD with postdoctoral research experience
  • Documented research experience in one or more of the following fields: High-throughput biology and/or Next Generation Sequencing method development, DNA repair and genome stability, Immunology or stem cell biology
  • Fluent oral and written communication skills in English
These qualifications count in the assessment
  • Python, Perl, R and other relevant programming language skills
  • Advanced statistics skills
  • Certification to independently supervise and conduct experiments on mouse models
We offer
  • salary NOK 524 200 – 597 400 per annum depending on qualifications in position as Researcher position code 1109
  • An exciting, translational project where your strong basic science background can directly benefit our sickest patients
  • Opportunity to shape a new laboratory
  • The possibility to develop your leadership skills when our team grows
  • attractive welfare benefits and a generous pension agreement, in addition to Oslo’s family-friendly environment with its rich opportunities for culture and outdoor activities

Apply here (email applications are not considered): 

https://www.jobbnorge.no/en/available-jobs/job/158270/senior-staff-researcher-crispr-gene-therapy-group

 

Post-doc Position Available – Medicine, Los Angeles, California

12.11.2018 | Avoimet työpaikat

https://www.exosome-rna.com/post-doc-position-available-medicine/?utm_campaign=shareaholic&utm_medium=twitter&utm_source=socialnetwork

Environment and Background

The Lawrence J. Ellison Institute for Transformative Medicine of USC is a multidisciplinary research institute developing innovative approaches in the prevention and treatment of cancer in order to significantly impact patients’ health and quality of life. We focus on understanding complex tumor-microenvironmental interactions and discovering optimal approaches for personalizing patient care. Our vision is to use a patient’s own metrics (genetic information, molecular tumor markers, dynamic tumor cell behaviors and drug responses across diverse microenvironments) to determine the most effective treatment. We are currently investigating a broad range of biological systems, including cell culture, mouse models, and patient-derived tissues.

Position Responsibilities

We are seeking a talented and passionate postdoc who has a strong interest in cancer biology. The qualified candidate will study the impact that exosomes derived from the tumor microenvironment have on pancreatic cancer initiation, progression, and therapeutic resistance using 2D and 3D cell cultures and mouse models. The projects will involve isolating extracellular vesicles produced by cancer associated fibroblasts, and pancreatic cancer cells; characterizing the cargo of the isolated microvesicles; and examining if the isolated microvesicles are able to induce phenotypic and genotypic changes on neighboring healthy and diseased cells. The candidate will work in close collaboration with a diverse team consisting of cancer researchers, computational scientists and clinicians. Key technical skills include mammalian tissue culture (2D and 3D), qRT-PCR, Western blot, immunofluorescence, and various cell proliferation and cell survival assays.

Requirements

Candidates should have a Ph.D. degree in molecular/cellular biology, biochemistry, or other relevant discipline. Candidates should have productivity as demonstrated by publication record. Applicants must have training in mammalian tissue culture (2D and 3D), experience with in vivo animal models, and familiarity with immunohistochemistry. Excellent verbal and communication skills, and the ability to work in a team environment are required. Key success factors in the performance of this position include being organized with the ability to maintain records accurately, the ability to collaborate across disciplines, and curiosity.

Interested individuals should provide their CV and a 1-2 page cover letter describing their professional goals and how their research experience can advance these research goals.

Other:

Preferred Education:  Ph.D. degree in molecular/cellular biology, biochemistry, or other relevant discipline
Preferred Experience:  1 year
Preferred Field of Expertise: Training in mammalian tissue culture (2D and 3D) and familiarity with exosomes, in vivo animal models, qRT-PCR, and immunohistochemistry.
Posting Salary Range:
Percentage of Time:  100%
Fixed Term:     Yes
Fixed Term:  1-year fixed term
Minimum Education: Ph.D or equivalent doctorate within previous five years
Minimum Experience: 0-1 year
Minimum field of Expertise: Directly related education in research specialization with advanced knowledge of equipment, procedures and analysis methods.

Multiple postdoctoral fellow positions are available at the Center for Childhood Cancers and Blood Diseases, Nationwide Children’s Hospital & Ohio State University, Columbus OH, United States

12.11.2018 | Avoimet työpaikat
Postdoctoral Fellow Positions in Epigenetics, human iPS cells, 3D Bioprinting, Cellular Therapies, Hematopoietic Stem Cell Biology, Bioengineering, and Blood Cancers: Columbus, OH, United States.

Multiple postdoctoral fellow positions are available in the Dhvanit Shah Laboratory (www.shahlaboratory.org) at the Center for Childhood Cancers and Blood Diseases, Nationwide Children’s Hospital & Ohio State University, Columbus OH, United States.

The Shah laboratory provides a dynamic microenvironment that offers excellent opportunities for intellectual exchange and collaborations among investigators from diverse fields. We investigate the origin, development, and differentiation of hematopoietic stem cells (HSCs), and their utility in treating patients with blood and bone marrow diseases. We have expertise in utilizing zebrafish, mice, and human induced pluripotent stem (iPS) cells to analyze novel genes and mechanisms important for blood formation. Our goals are to utilize our knowledge in developing cellular- and mechanism-based therapies as well as generating functional HSCs for the treatment of hematological diseases.

Position # 1: Epigenetics of Hematopoietic Stem Cell Development and Disorders.

The ideal candidate will have Ph.D., M.D., or M.D./Ph.D. in Regenerative Medicine, Stem Cells, Immunotherapy, Hematology, Oncology, and/or Biology. This position offers an excellent opportunity to learn and apply skills in epigenetics, directed differentiation of human induced pluripotent stem cells (iPSCs), HSC transplant, xenograft, computational biology, high-throughput screening, gene-editing, and/or molecular and cellular biology techniques.

Position # 2: Bioengineering of 4D or 3D Tissue Scaffold Development.

The ideal candidate will have Ph.D., M.D., or M.D./Ph.D. in Tissue Engineering, Biomaterials, Biophysics, Machine Learning, Systems Biology, Chemical Engineering, and/or Drug Development. This position offers an excellent opportunity to learn and apply skills in organoid development, 3D bio-printing, Bio-MEMS, artificial intelligence, microfluidics, proteomics, and/or medicinal chemistry.

Strong background in one or more of these areas is preferred but not required. Qualified candidate should be able to work independently as well as in a group environment. Positions are reviewed on a rolling basis and open until March 31, 2019.

Interested candidates should send their cover letter, CV, and contact details of three references to:

Dr. Dhvanit I. Shah
Center for Childhood Cancer & Blood Diseases,

Nationwide Children’s Hospital &

Ohio State University College of Medicine

700 Children’s Drive, WA 5015

Columbus, OH 43205

dshahlab@gmail.com

 

Ph.D. student – VTT, Vuorimiehentie 3, Espoo, 1 FI-02044, FI

8.11.2018 | Avoimet työpaikat

Ph.D. student – VTT, Vuorimiehentie 3, Espoo, 1 FI-02044, FI

Ph.D. student, fungal molecular biology

Form of employment: Full time, Fixed term

Locations: Espoo, Finland

Job area: Research and Development

Application period: Monday, October 29, 2018 – Sunday, November 25, 2018

With us you will be responsible for

completing your Ph.D. thesis on the study of cellular metabolism and production of extracellular proteins. You will be working as a part of an Academy of Finland funded research project “Interplay between metabolism and protein secretion in saprotrophic fungi”. The main emphasis of your work will be identifying important regulatory connections between cellular metabolism, secretory pathway and production of extracellular enzymes in the saprotrophic model organism Trichoderma reesei. As a member of the Protein Production Team, you will be part of wider efforts to better understand and develop fungal protein production hosts, such as Trichoderma reesei.

We expect you to have

completed your master’s degree so that you can start your Ph.D. thesis work in January 2019. You should have good laboratory skills and experience in molecular biology techniques and bioinformatics. Experience working with yeast or filamentous fungi would be beneficial, but not mandatory. Strong spoken and written English skills are required.

As a person you are

motivated to complete a Ph.D. thesis and willing to take initiative in getting the project accomplished. You should have strong communication skills as well as be able to work both independently and as a member of a team. You should have curiosity towards various scientific and technological challenges. You should be willing to travel and work abroad as part of short collaboration projects.

We offer

an opportunity to complete a Ph.D. thesis working on an interesting and cutting edge research project, expert guidance, and an opportunity to work with an experienced research team to better understand fungal protein production hosts used for production of industrial enzymes.

For further information

Chris Landowski
Research Team Leader
christopher.landowski@vtt.fi

R&D Scientist – PerkinElmer Inc., Turku, VARS

8.11.2018 | Avoimet työpaikat

R&D Scientist – PerkinElmer Inc., Turku, VARS

PerkinElmer is currently looking for

R&D Scientist with Bioaffinity Assay expertise

Turku, Finland

The Turku Site, with 550 employees, represents one of PerkinElmer’s major manufacturing and product development sites for newborn- and maternal fetal health screening. As the global market leader in newborn screening, our solutions have tested over 560 million babies worldwide for life-threatening diseases.

Role description:

  • You will be a key member and expert of technologies related to bioaffinity assays in product development teams
  • You will apply the scientific method to solve problems and to design new products that are safe and effective in their intended uses
  • You will have an essential role in planning and reporting of feasibility, stability and verification studies, and process characterization and validation studies
  • You will work in the lab yourself as well as direct the work of lab technicians
  • You will be interacting a lot within your team and with other teams from various functions present at Turku site and other PerkinElmer sites

Role requirements:

  • Degree (MSc or PhD) in Chemistry/Biology/Biochemistry or equivalent education
  • Proven expertise on bioaffinity assays (immunoassays, ligand binding assays) and especially: DELFIA, ELISA, CLIA, Upconverting label technologies
  • Fluent reporting and communication skills in English and Finnish
  • Proactive, resourceful, independent and a good team player in the cross-functional and international development team
  • Strong background and practical working knowledge from GLP/GMP level Pharma, Biotech or Life Science industry

What we offer:

  • Inspiring leadership and exceptional employees
  • Dynamic and innovative culture
  • Focus on career development
  • Collaborative and diverse environment

This position is permanent. Please apply by November 18th, 2018.

PerkinElmer Turku Site is a drug free site and a medical examination for new employees includes a drug test.

Open position for a Postdoctoral Fellowship (RNA Metabolism in Innate Immunity) at the National Institutes of Health (NIH), Bethesda, Maryland

7.11.2018 | Avoimet työpaikat
NIH-funded Postdoctoral Fellowship Position, to begin as early as June 2019
(duration: 2-5 yrs).
RNA Metabolism in Innate Immunity
National Institutes of Health (NIH), Bethesda, Maryland
 
The Fellow will investigate molecular mechanisms involved in RNA metabolism relevant to cytoplasmic RNA polymerase III (cyto-Pol III)-mediated innate immune mRNA induction and metabolism. Candidates must hold a Ph.D. or M.D. and have less than 5 years postdoctoral experience.  Expertise in molecular biology, genetics and/or biochemistry is required, as are strong letters of recommendation.  The successful candidate will confer regularly with the principal investigator but must develop self-directed research and have good technical, presentation, and communication skills as essential parts of the training experience.
Interested candidates should email a cover letter that details their specific interests in the research interests of the Maraia lab.
 
Interested candidates should send a cover letter that details their specific interests in the research areas of the Maraia lab, C.V. and a list of three references with their e-mail addresses and telephone numbers via e-mail to:
Richard J. Maraia, M.D.
Email: maraiar@mail.nih.gov
 
Maraia lab website: https://science.nichd.nih.gov/confluence/display/smcb/Home
 
Maraia lab interests:
•cytoplasmic RNA polymerse III (cyto-Pol III)-mediate innate immune response
•mRNA biased codon use and effects of variable tRNA gene complement.
•Anticodon modification by tRNA isopentenylytransferase and its role in translation.
•Molecular mechanisms of La-related protein -4 (LARP4) function in translation.
•Role of the La protein in tRNA production.
•Molecular mechanisms of transcription termination by RNA polymerase III.

 

Solubiologi-lehti etsii toimittajaa Oulusta!

6.11.2018 | Ajankohtaista

Oletko kiinnostunut tieteellisestä kirjoittamisesta? Kaksi kertaa vuodessa ilmestyvä Solubiologi-lehti etsii uutta toimittajaa Oulusta! Kiinnostuneet voivat ottaa yhteyttä lehden päätoimittajaan, Jenny Joutseneen, jenny.joutsen@abo.fi!