Ajankohtaista

Erikoistutkija proteiinikemian ydinpalveluyksikölle Turku Protein Core (määräaikainen työsuhde)

20.7.2021 | Avoimet työpaikat

https://www.utu.fi/fi/yliopisto/tule-meille-toihin/avoimet-tehtavat

BioCity Turku on Turun yliopiston ja Åbo Akademin yhteinen organisaatio, joka tukee ja koordinoi Turun seudun biotieteiden tutkimusta. BioCity Turun kansainväliseen tutkijayhteisöön kuuluu yli 140 tutkimusryhmää.

Molemmilla Turun yliopistojen ydinpalveluyksiköillä on merkittävä määrä proteiinipuhdistukseen, proteiinikemiaan, proteiinienvälisten vuorovaikutussuhteiden tutkimiseen ja biofysikaalisiin proteiinianalyyseihin liittyviä laitteistoja (mm. https://bioscience.fi/services/protein-structure-and-chemistry/services/). Turku Protein Core (TuProtCore) on keväällä 2021 käynnistetty ydinpalveluyksikkö, joka takaa BioCity Turun tutkijoille maksimaalisen käyttöhyödyn olemassa olevista proteiinikemian laitteistoista. TuProtCore tarjoaa kaikille tutkijoille ja yrityksille avoimia yhden pysäkin palveluja, jossa saa käyttöön kaikki proteiinikemian palvelut. TuProtCoren johtoryhmään kuuluu molempien yliopistojen proteiinikemian tukijoita, ja johtoryhmä ohjaa TuProtCoren toimintaa.

Tärkeimmät tehtävät

TuProtCore rekrytoi erikoistutkijan hoitamaan asiakaspalvelua ja järjestämään ydinpalveluyksikön toimintaa. Hänen tehtäviinsä kuuluu asiakkaiden opastaminen laitteiden käytössä ja uusien asiakassuhteiden tavoitteleminen sekä akateemisesta maailmasta että sen ulkopuolelta. Työnkuvaan kuuluu myös laitteistojen ylläpitoon liittyvää laboratoriotyöskentelyä, laitteiden käyttöohjeiden suunnittelua sekä proteiinin tuotto- ja analysointityötä. Erikoistutkijan tulee olla asiakaspalveluhenkinen ja proteiinikemian osaamisen on oltava erinomaista. Työtehtävä sijoittuu teknillisen tiedekunnan bioteknologian laitokselle, biokemian osastolle (https://www.utu.fi/fi/yliopisto/teknillinen-tiedekunta/bioteknologia).

Vaadittavat ominaisuudet

  • tohtorin tutkinto (tai lähes valmis tohtorin tutkinto) soveltuvalta tieteenalalta.
  • käytännön vankka kokemus proteiinikemiasta, erityisesti rekombinanttiproteiinien tuotosta ja analysoinnista (mm. Äkta, SEC-MALS, Calorimeter).
  • vertaisarvioituja tieteellisiä julkaisuja proteiinikemiasta ja/tai proteiinianalyysimenetelmistä.
  • hyvä englanninkielen suullinen ja kirjallinen taito, sekä vahvat henkilösuhde- ja verkostoitumistaidot.

Eduksi katsottava kokemus

  • verkkosivujen tekemisestä ja päivittämisestä
  • budjetoinnista, laskutuksesta, asiakaspalvelusta ja hallinnollisista tehtävistä
  • ydinpalveluyksiköiden toiminnasta tai vastaavasta tutkimuspalvelusta akatemiassa tai teollisuudessa.

Palkkaus

Palkka määräytyy yliopistojen työehtosopimuksen perusteella. Tehtävä kuuluu opetus- ja tutkimushenkilökuntaan ja keskimääräinen palkka maisterille (joka pian väittelee) on noin 2600-2900 eur/kk ja tohtorille noin 3100 – 3600 eur/kk. Tehtävässä on kuuden kuukauden koeaika.

Sopimuksen kesto

Työn toivottu aloitusajankohta on syyskuu 2021, mutta asia on neuvoteltavissa. Tehtävässä on kolmen vuoden määräaika, mutta on mahdollista, että hanke saa jatkoa. Työsopimuksessa sovelletaan kuuden kuukauden koeaikaa.

Hakeminen

Lähetä englanninkielinen hakemuksesi viimeistään 31.7.2021 yliopiston sähköisen hakujärjestelmän kautta: https://www.utu.fi/fi/yliopisto/tule-meille-toihin/avoimet-tehtavat. Hakemukseen tulee liittää seuraavat englanninkieliset liitteet:

  • motivaatiokirje (max 1 sivu) joka keskittyy asiakaspalvelun ja proteiinikemian vahvuuksiisi
  • ansioluettelo
  • tutkintotodistusten kopiot (voivat olla myös suomeksi)
  • vähintään kolmen suosittelijan yhteystiedot (nimi, työpaikka, sähköpostiosoite)
  • julkaisuluettelo

 Lisätietoja tehtävästä antaa Jukka Westermarck (jukka.westermarck(at)utu.fi). Hakemismenettelyä koskeviin tiedusteluihin vastaa tech-hr(at)utu.fi

Product Marketing Manager – Structural Cell Biology

20.7.2021 | Avoimet työpaikat

https://jobs.thermofisher.com/global/en/job/166882BR/Product-Marketing-Manager-Structural-Cell-Biology

The Mission

You will be a part of the Life Science Business Unit (LSBU) within Material and Structure Analysis Division (MSD) of Thermo Fisher Scientific. The LSBU provides high-value Electron Microscopy workflow solutions for high resolution biological imaging, ranging from atomic resolution imaging of protein complexes to volume acquisition of cellular compartment structures.

The Job

You will lead and drive product marketing for Structural Physiology. This segmented aims to attract cell biologists with a portfolio ranging from Large volume analysis to the powerful context of Cryo Tomography on whole cells and tissues. You will oversee product development (PMP) execution for products in Life Sciences from a marketing perspective interacting with the Product Development Team. Furthermore, you will contribute to building and executing a strong portfolio roadmap, built on market-focused strategy, deep understanding of product life cycles, and a broad business insight.

What will you do?

  • Work with other product managers and marketing managers to establish market requirement documents for structural physiology;
  • Develop value proposition, messaging and go-to-market strategies that resonate with the structural physiology segment, based on deep insight in and organizing around customers’ key scientific questions. Define innovative and creative ways to approach new market segments.
  • Build external networks e.g. in the context of collaborations: establish and manage technical collaborations with (KOL) customers, track milestones and report out on progress;
  • Build internal networks especially with R&D, NanoPort & field applications, marketing teams;
  • Drive improvement in product development processes and execution, identify and resolve roadblocks, apply PPI to monitor and continuously improve efficiency and effectiveness of strategy execution;
  • Provide support to sales and business development teams, support field escalations through coordinating technical expertise, providing an effective interface with R&D and engaging in technical and scientific discussions with customers.

Who We Are Looking For

The successful candidate will possess the following combination of education and experience:

  • Typically, a university degree is required, and a PhD/MBA or other advanced degree is preferred, or a combination of education and experience that demonstrate the required skills;
  • Typically requires at least 5 years of experience in high-tech product management environment;
  • Customer oriented, with a proven ability to build consensus and get buy-in and participation from key stakeholders; strong verbal and written communication skills across all levels and an ability to communicate complex technical concepts to a variety of audiences; fluent in English;
  • Proven ability to interact with cross-functional and cross-cultural teams; great team player who thrives in a matrixed organization, is flexible and deals well with dynamic requirements;
  • Keen interest in commercial, marketing and business aspects;
  • Ability to create a vision for a product, translate it into strategy and execute a value-driven roadmap;
  • Ability to travel internationally (up to 30%), and in possession of a valid passport.

Laboratory Technician

20.7.2021 | Avoimet työpaikat

Are you interested in shaping the future of health and work in a state-of-the-art laboratory with cutting edge analytical technology?

We (Nightingale Health) are looking for a Laboratory Technician to join our team in Kuopio. You’ll be part of our dedicated Lab Delivery team that consists of laboratory experts delivering high quality results to our customers globally in a fast-growing biotech, consumer health and health service industry.

Does this sound interesting? Read on.

As a Laboratory Technician at Nightingale you’ll have the chance to:

  • Be a part of our fast-paced delivery team that serves global customers by analyzing blood samples.
  • Handle sample preparation and processing.
  • Deliver analytical measurements using our proprietary technology that is based on nuclear magnetic resonance (NMR) spectroscopy.
  • Take part in service and maintenance activities in the laboratory.

What we’re looking for:

  • A trained laboratory technician (or equivalent) who is passionate about utilizing our proprietary technology for blood sample analyses.
  • An enthusiastic and dependable person with a solid understanding of analytical and/or clinical chemistry.
  • Knowledge and experience of analytical measurements.
  • A “can-do and quality first” mind-set.
  • Willingness to adapt to a flexible team culture and take on new challenges.
  • A strong knowledge of the English language. Finnish is a plus but not mandatory.
  • Previous working experience in a clinical laboratory, NMR spectroscopy or automated liquid handlers is not required, but is considered an asset.

What we offer:

  • Meaningful work that offers you the opportunity to focus on an essential part of our delivery process and to develop your skills as a laboratory professional.
  • Responsibility and independence as an accountable member of our Lab Delivery function.
  • A unique opportunity to work in a multidisciplinary organisation of scientists, business professionals, developers, designers and biotech business experts.
  • A competitive salary.
  • Full fringe benefits for health and wellbeing including massage, commuting, sports and culture.
  • An in-house chef and cafe that serves warm lunch every day.
  • Premium health insurance.
  • Interesting hobby clubs from running to music (we have an in-house band!)

This is a fixed-term position from August 2021 until the end of August 2022 and it is based in Kuopio.

A bit more about us:

Nightingale Health is a health technology company transforming preventive care. We envisage a world that focuses on keeping people healthy rather than just treating illnesses. By combining our pioneering blood-testing technology and the ability to detect future disease risks, we are creating a world-leading health data platform that enables preventative care with better information. The platform helps people make better personal health decisions and connects the health industry to offer their services for individuals’ preventative needs. By empowering the world with comprehensive health insights, we accelerate scientific discoveries, industry developments and improve personal health for everyone.

Your next steps:

Step 1: Follow the link below and fill in your information along with your CV and a cover letter.

Step 2: Have a quick chat over the phone with our Head of Lab Delivery Heta Forsström.

Step 3: Meet our Laboratory Director Pasi Soininen and Laboratory managers Harri Koskela and Mika Tiainen.

Step 4: Meet our Lab delivery team members.

Step 5: Meet our CEO Teemu Suna for the final interview.

Please send your application by August 2nd 2021. We’ll review all applications by August 5th and contact all candidates on the 9th of August at the latest.

Would you like to know more?

In case you have questions, feel free to e-mail our Head of Lab Delivery Heta Forsström at heta.forsstrom(at)nightingalehealth.com.

TUOTESPESIALISTI Solubiologian ja proteiinituotteiden pariin

20.7.2021 | Avoimet työpaikat

https://bionordika.fi/images/Tuotespesialisti_BioNordikaan.pdf

Etsimme dynaamisen ja innokkaan myyntijoukkomme vahvistukseksi tuotespesialistia solubiologian ja
proteiinituotteiden vastuualueelle.

Työtehtävät

  • edustamiemme yritysten tuotteiden myynti ja markkinointi
  • asiakassuhteiden hoitaminen ja uusasiakashankinta tapaamisilla, näyttelyillä, puhelimitse, sähköpostitse
    ja etätyösovellusten kautta
  • kampanjasuunnittelu ja markkinointimateriaalin tuottaminen
  • tarjouksien tekeminen
  • asiakastietokannan ylläpito CRM-järjestelmän kautta
  • BioNordikan pidempiaikaisen strategian eteenpäin vieminen

Odotamme sinulta

  • luonnontieteellisen alan korkeakoulutusta ja laboratoriolan tuntemusta, alan työkokemus on eduksi
  • positiivista, aktiivista otetta työtehtäviin, olet tiimityöntekijä
  • alan tekniikoiden hallintaa, esim. Western blot, IHC, IF, proteiinikemia. Molekyylibiologian tuntemus
    luetaan eduksi
  • sujuvaa kirjallista ja suullista suomen ja englannin kielen taitoa
  • ajokorttia ja valmiutta matkustaa asiakaskäynneillä Suomessa ja edustamiemme päämiesten
    koulutuksissa ulkomailla
  • halua rakentaa, ylläpitää ja kehittää hyvät suhteet asiakkaisiimme ja edustamiimme yrityksiin
  • halua pysyä mukana bioalan kehityksessä ja tuoteuutuuksissa

Tarjoamme

  • vakituisen työpaikan kuukausipalkalla, auto- ja puhelinedun
  • työympäristön ja työtiimin, joka on avoin, iloinen, motivoitunut ja aktiivinen
  • monipuolisia työtehtäviä, mahdollisuus kehittyä alan parissa
  • vahvan asiantuntijatuen talon sisältä ja päämiehiltämme

Bionordika Finland Oy ”Science where you are”, ”Your Scientific supplier” on suomalainen yritys, joka
tuo maahan korkealaatuisia Life science -tuotteita maailman johtavilta valmistajilta solu- ja
molekyylibiologiaan, immunologiaan, proteiinikemiaan, diagnostiikkaan sekä erikoislaitteita
reagensseineen. Edustamiamme yrityksiä ovat mm. New England Biolabs, Cell Signaling Technologies,
Lonza, Eppendorf, Eurogentec, Greiner Bio, Vector, AssayGenie. Haluamme palvella asiakkaitamme
ammattitaitoisesti ja asiakaslähtöisesti niin tuotetietouden, toimitusten kuin logistiikan suhteen. Juuri
remontoitu toimistomme sijaitsee Helsingissä, Pitäjänmäellä. Kuulumme vakavaraiseen ja Euroopan
laajuiseen AddLife -yrityskonserniin.


Hakemukset 31.7.2021 mennessä. Lisäkysymykset sari.nousiainen@bionordika.fi puh. 040-541 5080

Molecular Modelling Mage – Orion

15.7.2021 | Avoimet työpaikat

https://www.orion.fi/en/careers/open-vacancies?rmpage=job&rmjob=1138&rmlang=UK

Orion Corporation operates in more than 20 countries, where we Orionees, 3200 in total, work in all kinds of positions. Among us there are Research Scientists, Laboratory Technicians, Engineers and IT Specialists as well as people working in Production, just to mention some examples. We offer diverse and responsible jobs to our personnel in a truly multi-disciplinary work environment. We encourage people to develop their competences and offer opportunities to affect the job description and creating their own career path at Orion. We are searching for top talents who are ready to share our passion for the work that we do.

Orion is seeking a Molecular Modelling Mage (an experienced Senior Scientist) to further develop  our capabilities and push the boundaries of theoretical drug discovery research carried out in Computational Medicine Design (CMD) unit.

Description of position

The Molecular Modelling Mage will work in the drug discovery projects linking and interfacing with biology and chemistry with both ab initio and data-driven perspectives. For this, it is critical to constantly rediscover the best suitable strategy for each project and define how to increase the target understanding and how to navigate the path of multiparameter optimization in modality design. For example, approaches can be both ligand- and structure-based virtual screening and design, protein modelling, physics-based simulations, structure-activity data analysis, machine learning and utilization of variety of in-house and public data sources. The Molecular Modelling Mage will collaborate closely with a broad range of scientists including other modellers in the CMD unit, medicinal chemists, pharmacologists and biologists.

The position is full-time and you will be based in Espoo or Turku, Finland.

Description of unit

Orion is a globally operating Finnish company listed on the Helsinki Stock Exchange. Orion develops, manufactures and markets human and veterinary pharmaceuticals, active pharmaceutical ingredients and diagnostic tests for global markets. Orion’s pharmaceutical innovations are created within its R&D organization, including e.g. non-clinical research, clinical development, formulation development and medical affairs. The organization employs top professionals in the field of drug molecule development and optimization.

Medicine Design contributes to the drug discovery process of Orion R&D from target validation all the way to the candidate nomination. We are responsible for translating new drug targets to therapeutical modalities together with other line functions. Our scientists in biology, chemistry and computer-aided medicine design are key players in the multiple research programs driven by Orion’s therapy areas of Neurological Disorders and Oncology. We also support our colleagues around R&D with our core competences.

Requirements

To be a successful Molecular Modelling Mage, you should have the following educational and professional work experiences:

  • Ph.D. from a suitable field, e.g. computational chemistry, bioorganic chemistry, biophysics, computer science or biochemistry
  • Concrete post-doctoral or industrial experience (above five years)
  • Broad experience in computational drug design, mastery of state-of-the-art ligand- and structure-based methods and their applications for medicine design
  • Solid understanding of fields relevant in the discovery process (e.g. medicinal chemistry, pharmacology, biochemistry, cell biology, structural biology, biophysics)

In addition, in depth experience in at least one of the following aspects:

  • Application of large-scale modern data science, machine learning and cheminformatics for drug discovery
  • Large-scale molecular dynamics simulations (e.g., relative and absolute free energy methods) for protein-ligand complexes
  • Track record of progressing modalities from hit identification through lead to clinical candidate

Experience with commercial molecular modelling software platforms, data pipelining tools (e.g. Knime) and programming/scripting/data analysis/data visualization (e.g. Python) is desirable.

We expect from all scientists the ability to work both independently and in multidisciplinary teams consisting of in-house scientists and external collaborators. A demonstrated record of research productivity and excellent oral and written communication skills in English are expected.

We offer

We offer you great, highly professional & experienced colleagues and the opportunity to show your talent and challenge yourself with interesting tasks in a modern multidisciplinary environment. Computational methods play a key role in Orion drug discovery so this is an opportunity to contribute to helping patients in need. Generous health and welfare benefits are available, as well as support for international relocation. Read more about R&D’s pipeline from here. 

Additional information

Is this the position you have been waiting for? Please send your cover letter and CV by 8th August 2021 and let us know what inspires you! Our application period is extended due to holiday period in Finland.

For additional information on the position, please contact Heikki Käsnänen, Head of Computational Medicine Design, +358104265279, during the following times: July 8th and 9th: 11 AM to 2 PM (EEST).

#LI-ORION

Approved medical examination which also includes drug testing is required prior to the employment. We will also carry out a security clearance prior to the employment for the selected person.

Postdoctoral Researcher – University of Helsinki

15.7.2021 | Avoimet työpaikat

https://www.linkedin.com/jobs/view/2626392213/?refId=3gdcRSAtQsadZkzMgwdPMQ%3D%3D

Postdoctoral researcher with extensive experience in animal work, particularly mice or hamsters. Two projects available: 1) Stabilization of vaccines so that can be stored at room temperature. 2) Understanding how SARS-CoV-2 enters and spreads in the upper respiratory epithelium.


The position is available from Sptember 1st 2021 and it is for at least 1.5 years.
For more information please contact giuseppe.balistreri@helsinki.fi

Biotekniikan tutkimusasiantuntija & Back Office -asiantuntija – Finnadvance

15.7.2021 | Avoimet työpaikat

Finnadvance Oy kehittää innovatiivisia mikrofluidisia viljelyalustoja ja elinmalleja turvalliseen, luotettavaan ja kustannustehokkaaseen lääkeaineiden testaukseen teollisuudelle sekä akateemiselle tutkimukselle. Alustat on suunniteltu jäljittelemään olosuhteita ja toimintoja ihmisen elimissä ja mahdollistavat näin ihmiselle paremmin sopivien lääkkeiden löytämisen. Tämä alentaa kustannuksia vähentämällä epäluotettavien ja kalliiden eläinkokeiden tarvetta. Finnadvance Oy on perustettu joulukuussa 2018 ja toimii Oulussa.

Tehtäväkuvaukset

Finnadvance etsii:

Biotekniikan tutkimusasiantuntijaa liittymään nopeasti kasvavaan soluviljely- ja/tai biotuotantotiimiin. Keskeinen tehtäväsi on auttaa sisäisessä kehittämisessä ja tutkimustyössä,  Organ-on-Chip -elinmallien/sirujen kehittämisessä ja niiden simuloinnissa ja valmistuksessa. Yhteisyössä tutkimus- ja kehitystiimin kanssa etsit sopivia valmistusmenetelmiä ja -materiaaleja  OoC -siruille, ratkaiset ongelmia data-analyysien tuottamiseksi ja osallistut tutkimusraporttien ja tuotekuvausten laatimiseen.

Hakijalta edellytetään korkeakoulututkintoa (biokemia, mekaaninen/lääketieteellinen tekniikka, biotekniikka tai materiaalitiede), erinomaista englannin kielen taitoa ja kokemusta 3D-solubiologian, farmakologian, soluviljelmien, kuvantamismenetelmien ja biokemiallisten kokeiden alalta. Arvostamme myös aiempaa kokemusta esimerkiksi mikrofluidistiikan tai materiaalitieteen, valmistusprosessien ja laadunhallintajärjestelmien parissa, CAD-kokemusta sekä ohjelmointitaitoja.

Back Office -asiantuntijaa liittymään nopeasti kasvavaan tiimiimme. Tärkein tehtäväsi on avustaa projektinhallinnassa ja yleisessä dokumentoinnissa, osallistua verkkosivujen suunnitteluun ja ulkoiseen viestintään sekä osallistut tutkimusraporttien ja tuotekuvausten laatimiseen.

Hakijalta edellytetään korkeakoulututkintoa (biokemia, biolääketieteellinen tekniikka, biotekniikka tai siihen liittyvä ala), kokemusta verkkosivujen suunnittelusta ja kirjoittamisesta, sekä kokemusta projektinhallinnasta. Arvostamme kykyä hallita yksityiskohtia ja laajoja kokonaisuuksia sekä erinomaista englannin kielen kirjallista taitoa (suomen kielen taito luetaan eduksi).

Lue lisää Finnadvancesta

QC Manager – FinVector Oy

15.7.2021 | Avoimet työpaikat

https://www.sympahr.net/public/pq.aspx?816287c9&lang=en-US

We are looking for a QC Manager to lead and reinforce our Quality Control team.

Suitable candidate has previous experience in managing people and analytical lab work. Understanding of quality systems and pharmaceutical industry are seen as a plus.

Your main responsibilities include managing the overall work of the QC department and overseeing QC activities. As QC Manager you are establishing priorities, monitoring the progress of all assigned tasks, allocating resources and ensuring that the tasks meet milestones and deadlines.  

You could be the person if…

You are able to set direction, define suitable course of action, and delegate responsibilities in a practical manner. Moreover, you are proficient at planning, efficient in time management and good at organizing needed resources.

You are able to make clear decisions and take responsibility over tasks and people

You are resourceful and able to apply your expertise in QC activities. You share your knowledge to the team and organization.

You are able to work in a systematic and strategic manner to achieve objectives. You are able to see future prospects and have overall vision of your own responsibility area.

You are good at building relations within the organization and you find it easy to communicate at all levels of the organization. You understand different functions in the organization and the links between them.

Most importantly, as QC Manager you need to inspire, support and develop your team!

In order to succeed, you would need a degree in the field of laboratory, bioanalytics, cell biology, biochemistry or any other related field of study. You also need to communicate fluently both in written and spoken English.

The position is permanent and we hope that you are able to join our team in September. This role is new in our organization due to our ongoing growth.

We offer you an active and lively work community with diverse staff. We provide you occupational health-care and we support your well-being by ePassi-account. Furthermore, we will support your personal development.

Please apply by 1.8.2021!

For more information, please contact Anna-Kaisa Lehtivarjo, tel. 050-3407250. You’ll reach Anna-Kaisa from 19.7. on during office hours.


Analytical Development Scientist – FinVector Oy

15.7.2021 | Avoimet työpaikat

https://www.sympahr.net/public/pq.aspx?c5795d9c&lang=en-US

We are looking for Analytical Development Scientist to our growing MSAT team.

MSAT stands for Manufacturing, Science and Technology. At MSAT we have three core functions that oversee Analytical development, Manufacturing process development and Chemistry, Manufacturing and Controls (CMC) management.

The Analytical Development team is in charge of development, optimization and validation of new analytical procedures and/or optimization of the current established ones. MSAT also supports regulatory filings to enable robust clinical and commercial supply, health authority communication, due diligence and business development opportunities. 

Your primary responsibility as an Analytical Development Scientist is to be a Subject Matter Expert (SME) for assigned assays. You will focus on assay development by using analytical models to support root cause investigations and evaluating process improvements.

It is an advantage if you already have some experience of GMP-work and/or you are familiar with quality systems. Moreover, experience in cell culture assays will help you to get into the work more easily.

You could be the person if…

You produce clear, easily understandable and accurate documentation in English.

You have good skills in analyzing data, both verbal and numeric. You are also seeking new information to solve challenges and make decisions based on the data.

You are able to innovate new ideas, approaches and views. You also enjoy developing yourself.

Your work approach is precise and you achieve objectives set to you in a timely manner.

In order to succeed, you would need a degree in the fields of biosciences, cell biology, chemistry, biochemistry, biotechnology or any other related field of study.

As a person, we would like you to be open-minded towards new challenges and spread good team spirit. You also need to communicate fluently both in written and spoken English.

We hope you to start in September 2021.

We offer you active and lively work community with highly skilled and experienced personnel in gene therapy manufacturing. Working with us, you are entitled to good employment benefits, such as extensive occupational health-care and ePassi- account. We provide you a wide induction training and a warm welcome.

Apply by 1.8.2021!

For more information, please contact Minna Hassinen, tel. 050-4336447. You’ll reach Minna 8.-16.7.2021 during office hours.

Early Stage Researcher, Neurobiology of Disease – University of Eastern Finland

15.7.2021 | Avoimet työpaikat

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 101034307.

PROPOSED TOPIC FOR PHD
New biomarkers for mental health

DOCTORAL PROGRAMME
Doctoral Programme of Molecular Medicine (DPMM)

THE PRIMARY SUPERVISOR AND CO-SUPERVISORS
Katja Kanninen, primary supervisor
Izaque de Sousa Maciel, postdoc in the Kanninen research group
Päivi Eriksson
Noora Puhakka

HOST RESEARCH UNIT AND HOST RESEARCH TEAM AT THE UNIVERSITY OF EASTERN FINLAND (UEF)

A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences

The goal of the ‘Neurobiology of Disease’ research group is to provide in-depth understanding of the cellular and molecular events that occur in brain disorders. By using human biosamples we aim to discover biomarkers for mental health dysfunction in order to provide novel solutions for patient benefit. Biomarker discovery is facilitated by using highly sophisticated, integrative omics approaches. Validation and detailed testing is carried out in human cells, and animal disease models. We are increasingly interested in deciphering how environmental factors shape the brain and affect mental health.

EXPECTED PROFILE OF THE PHD CANDIDATE
This research project needs the participation of people with passion for excellence in research, innovation, and societal impact. We are looking for candidates who seek to contribute to brain health innovation research with a keen eye on the application of research knowledge to the problems and challenges of society and industry. Ideal candidates want to open their minds to intersecting and complementary fields of science, seeking a multi/interdisciplinary approach in research. The candidates should have a desire to approach the brain health industry and other organizations that will benefit from science when developing services, products, and processes.

The academic profile of the candidate should be in the neuroscience or biomedicine, with the idea of complementing this background throughout PhD studies. Overall, the candidate must be willing to combine complementary areas of knowledge in innovation management, data sciences, social sciences, applied physics and/or law to complete the thesis project. Moreover, the candidate is required to have good methodological skills, especially in longitudinal analyses. As far as soft skills are concerned, we welcome candidates with a proactive, collaborative attitude, and who are enthusiastic about building, creating, and working in teams. Excellent candidates desire to participate in activities concerning multi- and interdisciplinary ageing research, and are willing to spend some time abroad with our international partners and outside the university in our partner institutions.

We are looking for a motivated candidate to work on a highly novel project that identifies, validates and characterizes new omic biomarkers for childhood and adolescence mental illness using human-based biosamples and animal models of neuropsychiatric disorders. You will be working with biosamples and omics data from children and adolescents that are at high risk of a mental health disorder, or that already have a diagnosis. If you wish, you may also join our animal studies on neuropsychiatric disease. You will join a very active and multidisciplinary, European-wide team of scientists (funded by Horizon 2020, project Equal-Life) studying various aspects of the exposome in relation to mental health. The project aims to tackle issues related to commercialization of novel biomarkers throughout the project. We expect you to have an inquisitive attitude and the ability to work in a highly dynamic, interdisciplinary team. A suitable background in neuroscience, omics approaches, bioinformatics or related fields are highly appreciated.

SCIENTIFIC RESEARCH AREAS RELATED TO THE TOPIC
Neuroscience, biomarkers, mental health, innovation, bioinformatics

DESCRIPTION OF THE NEURO-INNOVATION RESEARCH TOPIC
Adolescence is a crucial period for developing and maintaining social and emotional habits important for mental well-being. Some adolescents are at greater risk of mental health conditions due to their living conditions, lifestyle, genetic factors, and the environment they are exposed to. The goal of this research is to demonstrate proof of concept in being able to utilize newly discovered biomarkers for the early detection and risk stratification of mental dysfunction, especially targeting adolescents. This project will determine the utility and validity of novel biomarkers discovered by multiomic approaches for early identification of at-risk individuals and possible preventative measures. Additional functional data on the biomarkers will be generated with human biosamples and highly translational research models. The project also combines the biomarkers data on the living conditions of the adolescents. A key aspect of this project is to determine if the biomarkers have utility for risk prediction and commercialization potential. This project strives to meet the challenging outstanding medical need of early identification of mental health dysfunction in adolescence.

The candidate can also suggest their own topic or modify this topic in their motivation letter.

EXCELLENCE OF THE HOST RESEARCH TEAM

Publications related to the PhD topic

  • Lampinen R, Feroze M, Avesani S, Örd T, Penttilä E, Lehtola J-M, Saari T, Hannonen S, Saveleva L, Kaartinen E, Fernandes Acosta F, Cruz-Haces M, Löppönen H, Mackay-Sim A, Malm T, Kaikkonen-Määttä M, Koivisto AM, White AR, Giugno R, Chew S, Kanninen KM. Disease specific alterations in the olfactory mucosa of patients with Alzheimer’s disease. doi: https://doi.org/10.1101/2020.11.24.395947.
  • Kanninen KM, Lampinen R, Rantanen LM, Odendaal L, Jalava P, Chew S, White AR. Olfactory cell cultures to investigate health effects of air pollution exposure: Implications for neurodegeneration. Neurochem Int. 2020 Jun;136:104729. doi: 10.1016/j.neuint.2020.104729. Epub 2020 Mar 19. PMID: 32201281.
  • Chew S, Lampinen R, Saveleva L, Korhonen P, Mikhailov N, Grubman A, Polo JM, Wilson T, Komppula M, Rönkkö T, Gu C, Mackay-Sim A, Malm T, White AR, Jalava P, Kanninen KM. Urban air particulate matter induces mitochondrial dysfunction in human olfactory mucosal cells. Part Fibre Toxicol. 2020 Jun 1;17(1):18. doi: 10.1186/s12989-020-00352-4. PMID: 32487172; PMCID: PMC7268298.
  • Das Gupta S, Ciszek R, Heiskanen M, Lapinlampi N, Kukkonen J, Leinonen V, Puhakka N, Pitkänen A. Plasma miR-9-3p and miR-136-3p as Potential Novel Diagnostic Biomarkers for Experimental and Human Mild Traumatic Brain Injury. Int J Mol Sci. 2021 Feb 4;22(4):1563. doi: 10.3390/ijms22041563. PMID: 33557217; PMCID: PMC7913923.
  • Lehtimäki, H., Helén, I., Snell, K., Eriksson, P., & Montonen, T. (2019). Sustainable Value Creation in the Commercialization of Innovation: The Case of Auria Biobank. International Journal of Entrepreneurship and Innovation Management¸23(5), 451-465.

Research projects related to the PhD topic

MULTI/INTERDISCIPLINARY COLLABORATION
This PhD research topic covers the following complementary areas of knowledge: basic neuroscience, mental health, biomarker discovery, neuroinnovation, bioinformatics

The PhD project will be co-supervised by a team of 3 scientists with expertise in basic neuroscience, biomarker discovery, neuroinnovation and bioinformatics.

To advance multi/interdisciplinary collaboration, three Summer Schools will be organised jointly by the Neuro-Innovation supervisors and non-academic partners. In these, multi-/interdisciplinarity and intersectoral exchange will be implemented via hands-on interaction between PhD students, supervisors, partners and other stakeholders.

  • Neuro-ethics and patient rights, 3 ECTS credits. Research ethics, patient rights, data security.
  • Neuro-data Hackathon, 3 ECST credits. Open and big data.
  • Neuro-Innovation Living Lab, 3 ECST credits. Entrepreneurial processes and commercialisation paths.

Virtual Platform for multi/interdisciplinary interaction will connect all PhD students in this programme.

INTERNATIONAL COLLABORATION
The academic partner organizations (see the Neuro-Innovation webpage) will collaborate closely with us in PhD training and students are strongly encouraged to include a secondment and visits with these partners in their studies. During shorter visits (1-4 weeks), you will learn more about research and methods and build international networks. During secondments, you will work on their research project under the supervision of the co-supervisor from the hosting organisation and utilise their infrastructure. You can also attend courses, seminars, and other events in the host organisations.

The PhD candidate has the opportunity to visit one or two project partners for secondments, for example the University of Verona and BioTalentum Ltd, for a period that will be jointly agreed. This will enable the candidate to become familiar with the state-of-the-art methodologies in human biosampling and bioinformatics and gain knowledge in working in industrial settings.

INTERSECTORAL COLLABORATION

The Societal Impact Board of this PhD programme with 14 intersectoral partners will collaborate closely with us in PhD training, for instance on the following activities:

  • Neuro-Innovation Talent Hub: monthly gathering with special guests (e.g., researchers, professionals, business experts, stakeholders) and discussions about research topics and career prospects.
  • Neuro-Innovation Boot Camp: yearly competition concerning the utilisation of research results.

There is a particularly close collaborative relationship planned with BioTalentum Ltd as well as University of Verona in the proposed topic.

Close collaboration with clinicians, psychologists, bioinformaticians and innovation experts during the doctoral studies is highly recommended.

Apply the position

IMPACT
High quality research and publications of excellence are a way to solve scientific and societal problems and challenges. This vision is shared by the collaborating partners in this doctoral program, and involvement with various stakeholders will allow the pursuit of a goal with potential for brain health innovation. The University of Eastern Finland pursues societal impact that goes beyond academia focusing on the transformation of society, leading to fairer and more diverse societies, where inclusive social development and welfare are enhanced.

The objective of the proposed research is to advance our understanding of mechanisms of mental health dysfunction and discover and validate biomarkers to serve both diagnostic and potential therapeutic purposes. In the long run, the data from this study can be used to categorize individuals to risk groups, aid in early detection of potential mental health problems, leading to lowering of the disease burden.

INCLUSIVENESS AND EQUAL OPPORTUNITIES
The UEF policy on gender equality and equal opportunities is based on Finnish legislation and the values of the university. The goal of gender equality and equal opportunities at the university is to identify and prevent expressions, structures and functions that maintain or increase inequality and to promote gender equality and equal opportunities at all levels. The university has a Gender Equality and Equal Opportunities Programme, which describes the measures intended to implement and promote gender equality and equal opportunities among staff and students. The university takes an active approach to promoting equal opportunities and acting against discrimination.

UNIVERSITY OF EASTERN FINLAND IN BRIEF
The University of Eastern Finland is the most multidisciplinary university in Finland. We are home to 15,500 students and 2,700 staff members. Our research is ranked among the best in the world in several fields (inc. forest sciences). We generate research-based knowledge and make it openly accessible for the benefit of all. UEF stands for action with impact that is relevant today and tomorrow. To learn more about our university please visit our website at www.uef.fi/en.