Three post-doc positions in Strasbourg
21.12.20161: Physiology and pathology of development and function of basal ganglia – towards understanding and treatment of neurologic diseases
The project:
The project aims at characterizing basic mechanisms of neurogenesis in developing and adult striatum with particular focus on retinoid receptor signaling. Relevance of obtained data for understanding etiology and physiopathology of neurologic disorders including in particular restless legs syndrome (RLS; one of the most frequent neurodevelopmental disorders) will be investigated using new genetic mouse model of disease. The project will be carried out at IGBMC (Strasbourg-Illkirch), an international research institute located in the heart of dynamic research region at crossroads of France, Germany and Switzerland. It will benefit from such location and state-of-the-art infrastructure and expertise in developmental biology, animal behavior and pharmacology, genomics and bioinformatics. In addition, close collaboration with world leaders in clinical research in RLS and neurodegeneration will be mandatory to identify relevance of obtained data for the clinical condition and test new strategies of therapy.
The applicant:
We are looking for highly motivated post-doctoral fellow with solid research experience in molecular and cell biology, and biochemistry (experience in developmental neurobiology, primary mammalian cell cultures or life imaging will be a great asset). Experience in work with rodent models is encouraged. Candidate must have at least one first author publication. The ability to work in an English speaking team and good communication skills are required. The ideal candidate should be able to bring original input to the 2 1/2 year challenging project and participate in animating team’s life.
—————————–
2. mechanism of depressive behaviors
The project:
The global aim of the project is characterization of neuron-glia interactions in animal models of depression using electrophysiological approaches combined with histological and molecular analyses and behavioral, and pharmacological studies. The relevance of obtained data for research into treatment resistant depression will be tested using dedicated animal model and molecular analyses on human material obtained through collaborations with specialists in psychiatry and pharmacology. The project will be carried out at IGBMC (Strasbourg-Illkirch), an international research institute located in the heart of dynamic research region at crossroads of France, Germany and Switzerland. The project will benefit from such location and state-of-the-art infrastructure and expertise in animal behavior and pharmacology, molecular, genomic and bioinformatics analyses.
The applicant:
We are looking for highly motivated post-doctoral fellow with solid research experience in electrophysiology (whole cell recordings). Any additional experience in histology, imaging, molecular or cell biology will be welcome. Experience in work with rodent models is encouraged. Candidate must have at least one first author publication. The ability to work in an English speaking team and good communication skills are required. The ideal candidate should be able to bring original input to the challenging project and participate in animating team’s life.
—————————–
3. A vitamin for neuroprotection
The project:
The project aims at characterizing mechanisms of neuroprotective activities of retinoid signaling. This multidisciplinary project emerging from close collaboration with chemists will include genomic analyses (RNAseq, ChIPseq, proteomics) combined with analyses of neuron-glia interactions, mitochondrial functions. Neuroprotective activities of selected candidate genes and new bioactive metabolites will be also tested. The relevance of obtained data for research into neurodegenerative diseases will be determined using dedicated animal models, human cells cultured in vitro and human material obtained through collaborations with specialists in neurology. The project will be carried out at IGBMC (Strasbourg-Illkirch), an international research institute located in the heart of dynamic research region at crossroads of France, Germany and Switzerland. The project will benefit from such location and state-of-the-art infrastructure and expertise in animal behavior and pharmacology, molecular, genomic and bioinformatics analyses.
The applicant:
We are looking for highly motivated post-doctoral fellows who correspond to either of the following profiles: 1) solid research experience in biochemistry, mitochondrial biology and molecular biology or 2) solid research experience in genomic, bioinformatics analyses with an interest in extending his/her experience to developmental or molecular neurobiology. Experience with neural stem cells and primary neuronal cultures or studies of microglia cells are strongly encouraged. Candidate must have at least one first author publication. The ability to work in an English speaking team and good communication skills are required. The ideal candidate should be able to bring original input to the challenging project and participate in animating team’s life.
—————————–
Applicants should submit their complete application file (CV, motivation letter, publication list and contact to at least two reference scientists in one PDF file) by email.
Contact information:
Dr Wojciech Krezel (Research Director at INSERM)
IGBMC, 1, rue L.Fries, 67404 Illkirch (CU Strasbourg), France
email: krezel@igbmc.fr