6.9.2020 | Avoimet työpaikat
https://www.helsinki.fi/en/open-positions/postdoctoral-researcher-varjosalo-laboratory-of-molecular-systems-biology-pathology
The University of Helsinki, founded in 1640, is one of the world’s leading universities for multidisciplinary research. The university has an international academic community of 40,000 students and staff members. The University of Helsinki offers comprehensive services to its employees, including occupational health care and health insurance, sports facilities, and professional development opportunities. The International Staff Services office assists employees from abroad with their transition to work and life in Finland.
The HiLIFE – Institute of Biotechnology is a research institute that operates at the highest international level. It includes 40 research groups and 250 researchers. The Institute is situated in the Viikki science park. For more information on the Institute, please visit (https://www.helsinki.fi/en/hilife-institute-of-biotechnology).
The HiLIFE – Institute of Biotechnology, Varjosalo laboratory of Molecular Systems Biology / Pathology, invites applications for a
POSTDOCTORAL RESEARCHER
The Varjosalo lab has a longstanding interest in the global and comprehensive understanding of how key cellular signaling molecules; protein kinases, protein phosphatases and transcription factors mediate their signaling potential and how the signaling is changed in diseases in the immunology and oncology axis, and more recently Covid-19. For this purpose, we have developed experimental and computational methods to identify the protein-interactions formed by these signaling molecules. Additionally, we employ quantitative mass spectrometry -based proteomics to assess the protein abundance changes, as well as phosphorylation status of the tissues/cells. Furthermore, combining the data from the different sets of ‘omics’ data (proteomics, HTS and HiSeq), allows us to generate global and systems level understanding on how disease-causing mutations mediate their effects, also enabling the development of therapeutic or diagnostic approaches.
We are seeking a post doc that has extensive practical experience in standard biochemistry/molecular biology/cell biological methods, ideally encompassing proteomics and microscopic techniques and/or bioinformatics. The ideal candidate is an adaptable team-player with excellent communication skills, both oral and written, and good organizational skills.
This position will provide multiple opportunities for collaborations with potential lab visits abroad and cross-disciplinary scientific exchange, when applicable. An attitude to drive own research and work in an intra and inter team fashion is highly appreciated. In return, the candidate is offered access to a wide variety of methodologies and advanced techniques, appropriate supervision and help in career development.
More information about the lab, including the latest research and news, can be found here:
https://www.helsinki.fi/en/hilife-institute-of-biotechnology/research/st…
The position is initially limited to 2 years with a possibility of extension starting from October 2020. A trial period of 6 months will be applied, and the salary will be based on the Universities salary scheme for teaching and research personnel composed of both task specific and personal performance components.
The deadline for the applications is 25th of September, but the position will be filled immediately once a suitable candidate has been identified.
Application should include the following documents as a single pdf file: CV, list of publications, motivation letter including a description of your research interests, and the names and telephone numbers of at least two referees.
Please submit your application, together with the required attachments, through the University of Helsinki electronic recruitment system by clicking on the ‘Apply for job’ button. Internal applicants (i.e., current employees of the University of Helsinki) submit their applications through the SAP HR portal.
For further information please contact Research Director Markku Varjosalo, PhD
markku.varjosalo(at)helsinki.fi.
Due date
25.09.2020 23:59 EEST
6.9.2020 | Avoimet työpaikat
https://www.helsinki.fi/en/open-positions/doctoral-student-varjosalo-laboratory-of-molecular-systems-biology-pathology
The University of Helsinki is one of the world’s leading universities for multidisciplinary research. HiLIFE Helsinki Institute of Life Science is a research institute that supports high quality life science research across the University campuses and faculties. The research activities at the Institute of Biotechnology consist of several research teams focusing on a specific area of molecular biology, cell biology or biotechnology. The Institute is situated in the Viikki science park. For more information on the Institute, please visit https://www.helsinki.fi/en/hilife-institute-of-biotechnology.
The HiLIFE – Institute of Biotechnology, Varjosalo laboratory of Molecular Systems Biology / Pathology, invites applications for a position of
Doctoral Student
The ongoing pandemic of coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2). COVID-19 is currently rapidly spreading worldwide to over 180 countries, including Finland. To date, no specific antiviral drugs have been developed for SARS-CoV-2. Drug discovery is hindered by the fact that viruses do not have their own metabolism, but are dependent on the host. This project is part of a consortia grant funded by the Academy of Finland, aiming to fight the ongoing pandemic of COVID-19. The project is a combination of modern technologies used to study proteomics and genomics. The candidate will apply the interaction proteomics to construct a comprehensive virus-host protein interaction network and identify the potential protein targets for testing the available drug(s) against all possible variants or mutations of SARS-COV-2. The pipeline you will set up is important not only for the SARS-COV-2 but also for many other newly emerging viruses of interest.
We are looking for a highly-motivated candidate with a master’s degree in biology, biochemistry, biotechnology or other relevant fields. We expect the candidate to have practical experience with “wet lab” work and strong interest in the development and application of modern instrumentation to study host-pathogen interaction. Experience in proteomics is considered an advantage. The candidate should work well in a team as she/he will be integrated into an international research team of experts in system biology. The working language in the group is English.
The appointee is expected to work full time on the PhD thesis and to complete their thesis and the associated studies in four years. The successful applicant will apply to be a Ph.D. student in the appropriate Faculty (such as the Faculty of Medicine). PhD degree consists of the student’s research project and studies specific to the research field, as well as transferable skills training.
The position is available from September 2020. A trial period of 6 months will be applied, and the salary will be based on the Universities salary scheme for teaching and research personnel composed of both task specific and personal performance components.
The deadline for the applications is 25th of September, but the position will be filled immediately once a suitable candidate has been identified.
Application should include the following documents as a single pdf file: CV, list of publications, motivation letter including a description of your research interests, and the names contact information of two referees.
Please submit your application, together with the required attachments, through the University of Helsinki electronic recruitment system by clicking on the ‘Apply for job’ button. Internal applicants (i.e., current employees of the University of Helsinki) submit their applications through the SAP HR portal.
For further information please contact Research Director Markku Varjosalo, PhD
markku.varjosalo(at)helsinki.fi
Due date
25.09.2020 23:59 EEST
6.9.2020 | Avoimet työpaikat
https://www.helsinki.fi/en/open-positions/doctoral-student-in-molecular-biology-transcriptional-regulation
The University of Helsinki is a research-oriented university, which offers stimulating and international working environment. The Faculty of Medicine of the University of Helsinki, together with Helsinki University Central Hospital, The Helsinki Institute of Life Science, and the Institute for Molecular Medicine Finland forms the Academic Medical Center Helsinki. This medical campus ranks among the 10 best medical centers at European level.
DOCTORAL STUDENT IN MOLECULAR BIOLOGY or TRANSCRIPTIONAL REGULATION
The tentative starting date for the position is 1st of January 2021.
Dr. Harri Itkonen is setting up a new research group at the Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, and is looking for a highly motivated doctoral student to join his team.
The group of Harri Itkonen is looking for outstanding candidates for a PhD Student trainee position to study how metabolism is integrated to regulate global gene expression. We utilize a wide range of techniques including cell biology, organoid technology, live-cell imaging, mass spectrometry, ChIP- and RNA-seq among others to study processes that cancer cells are addicted to (see eg. Itkonen and al. Mol Cancer Res 2020; Itkonen and al. Theranostics 2019; Martin and al. J Am Chem Soc. 2018). The aim of the current project is to understand how the crosstalk between RNA polymerase II modifying enzymes regulates global gene expression.
We are looking a creative thinker with strong analytical skills and high motivation to develop novel therapies to treat cancer. Our group is well connected internationally, and the hired PhD Student will have a chance to present her / his findings in international conferences, and the training includes a tentative half a year research visit to University of Oxford.
The PhD Student candidate must hold, or soon receive, an MSc degree, and have background in molecular biology and / or bioinformatics. The ability to independent thinking and interest in computational biology will be prioritized. Strong written and oral communication skills in English are a must. Experience in one of the following methodologies: cell culture, RNA biology, ChIP- / RNA-sequencing is expected. Candidates are requested to familiarize themselves with the literature, and informal inquiries about the position prior to deadline are encouraged to harri.itkonen(at)helsinki.fi.
The appointee must apply and obtain the right to pursue a doctoral degree at the University of Helsinki within the probationary period of 6 months applied in the appointment.
The salary of the position is based on level 2 of the demands level table for teaching and research personnel in the salary system of Finnish universities. The starting salary will be 2200-2500 euros/month, depending on the appointee’s qualifications and experience.
University of Helsinki offers comprehensive services to its employees, including occupational health care and health insurance, sports facilities, and opportunities for professional development. The Faculty of Medicine has strong activities towards enhancing gender equality, diversity and employee wellbeing. The International Staff Services office assists employees from abroad with their transition to work and life in Finland.
To apply for this fully funded PhD training position, please submit the application through the University of Helsinki electronic recruitment system by clicking on Apply for job by September 30, 2020. Internal applicants (i.e., current employees of the University of Helsinki) please submit your applications through the SAP HR portal.
In your application, please include:
– a CV (with possible list of publications)
– a copy of your transcript records (the courses completed during MSc program; if you have not yet obtained your MSc degree, please include an estimated date for this)
– contact details of 1-3 references
-a cover letter (maximum 1 page) describing your research interests, experience in laboratory work and why you are an excellent candidate for this project
Due date
30.09.2020 23:59 EEST
6.9.2020 | Avoimet työpaikat
https://www.helsinki.fi/en/open-positions/post-doctoral-fellow-phd-student-in-the-field-of-functional-genomics-and-cancer-research
Post-doctoral fellow / PhD student in the field of functional genomics and cancer research (available immediately)
We are seeking a highly motivated and talented individual for working in the field of functional epigenomics in cancer research and transcriptional regulation.
The focus of the lab is to investigate the interplay between transcription factors and oncogenes using modern genome-wide methods for regulatory genomic features and chromatin architecture.
The group belongs to the Applied Tumor Genomics Program in the Research Programs Unit of the Faculty of Medicine at the University of Helsinki providing an excellent research environment with strong focus on cancer research. The center is very well equipped with modern facilities and supported with core facilities for genomics, next generation sequencing, proteomics, imaging etc. We offer a position in an ambitious, multi-disciplinary and well-resourced group that is comprised of both wet-lab and computational scientists
(https://www.helsinki.fi/en/researchgroups/enhancer-biology).
The candidate should have a PhD / Master’s degree in any field of life sciences or quantitative sciences with a particular interest in functional genomics and cancer research. The ideal candidates will be involved in generation and integration of functional genomics datasets from next-generation sequencing methods such as ATAC-seq, Hi-C, ChIP-seq, single-cell genomics as well as CRISPR-based approaches.
A good understanding of cell and molecular biology, biochemistry, genomics experiments and bioinformatics is expected. Prior experience in generation and analysis of high-throughput omics datasets is desirable and candidates with proven track record in terms of publications will be given preference, especially for postdoctoral fellows. With English as a working language, excellent oral and written communication skills are required.
Salaries are based on the salary system for Finnish universities (YPJ) in the range of 40,000 – 45,000 euros per annum for post-docs and 25,000 – 28,000 euros for PhD students depending on experience level, and a six-month trial period will be applied.
Details on the project and other informal queries are very welcome and should be sent to biswajyoti.sahu(at)helsinki.fi. Applications will be considered on a rolling basis till a suitable candidate is found.
Applications should be in a form of single pdf containing (1) a one-page cover letter describing your research goals, interest and motivation, (2) a recent curriculum vitae (CV) including publications, and (3) two–three reference letters with contact details of the referees.
Please apply as soon as possible or by October 8, 2020 via the University of Helsinki electronic recruitment system (by clicking on ”Apply for job”). Internal applicants (i.e., current employees of the University of Helsinki) must submit their applications through the SAP HR portal.
The Faculty of Medicine promotes scientific research of a high standard and is responsible for providing research-based undergraduate and postgraduate education in medicine, dentistry, psychology and logopedics, as well as for the English-language Master’s Programme in Translational Medicine. In addition to its teaching and research activities, the Faculty serves as a significant expert organisation in the healthcare sector and contributes to the discourse on ethics in the field. In terms of research, the Faculty aims for a place among the best medical faculties in the world, while consolidating and strengthening its status as a top-level institution of medical education.
Together with the Helsinki University Hospital (HUS) and the Helsinki Institute of Life Sciences (HiLIFE), the Faculty of Medicine, University of Helsinki, constitutes the Academic Medical Center Helsinki (AMCH). This medical center has been very successful in international comparisons, ranking among the top 10 medical campuses in Europe and among the top 50 globally.
Due date
08.10.2020 23:59 EEST
6.9.2020 | Avoimet työpaikat
https://www.helsinki.fi/en/open-positions/computational-biologist-bioinformatician-in-the-field-of-functional-genomics-and-cancer-research
Computational biologist / Bioinformatician in the field of functional genomics and cancer research (available immediately)
We are seeking a highly motivated and talented individual for working in the field of functional epigenomics in cancer research and transcriptional regulation. The focus of the lab is to investigate the interplay between transcription factors and oncogenes using modern genome-wide methods for regulatory genomic features and chromatin architecture. The group belongs to the Applied Tumor Genomics Program in the Research Programs Unit of the Faculty of Medicine at the University of Helsinki providing an excellent research environment with strong focus on cancer research. The center is very well equipped with modern facilities and supported with core facilities for genomics, next generation sequencing, proteomics, imaging etc. We offer a position in an ambitious, multi-disciplinary and well-resourced group that is comprised of both wet-lab and computational scientists (https://www.helsinki.fi/en/researchgroups/enhancer-biology).
The candidate should have a PhD / Master’s degree in any field of computer science, bioinformatics or life sciences with expertise in computational data analysis and strong motivation towards biomedical research. Prior experience in analysis of high-throughput genome-wide omics datasets from next-generation sequencing methods is desirable. Candidates should have a strong background in programming languages (Perl, Python, R etc.) and ones with proven track record in terms of publications will be given preference. A good understanding of biochemistry, genomics experiments and bioinformatics is expected. The ideal candidates will be involved in computational analysis and integration of functional genomics datasets such as ATAC-seq, Hi-C, ChIP-seq, single-cell genomics as well as genome-wide CRISPR-based approaches.
With English as a working language, excellent oral and written communication skills are required.
Salaries are based on the salary system for Finnish universities (YPJ) in the range of 40,000 – 45,000 euros per annum for post-docs and 25,000 – 28,000 euros for PhD students depending on experience level, and a six-month trial period will be applied.
Details on the project and other informal queries are very welcome and should be sent to biswajyoti.sahu(at)helsinki.fi.
Applications will be considered on a rolling basis till a suitable candidate is found.
Applications should be in a form of single pdf containing (1) a one-page cover letter describing your research goals, interest and motivation, (2) a recent curriculum vitae (CV) including publications, and (3) two–three reference letters with contact details of the referees.
Please apply as soon as possible or by October 8, 2020 via the University of Helsinki electronic recruitment system (by clicking on ”Apply for job”). Internal applicants (i.e., current employees of the University of Helsinki) must submit their applications through the SAP HR portal.
The Faculty of Medicine promotes scientific research of a high standard and is responsible for providing research-based undergraduate and postgraduate education in medicine, dentistry, psychology and logopedics, as well as for the English-language Master’s Programme in Translational Medicine. In addition to its teaching and research activities, the Faculty serves as a significant expert organisation in the healthcare sector and contributes to the discourse on ethics in the field. In terms of research, the Faculty aims for a place among the best medical faculties in the world, while consolidating and strengthening its status as a top-level institution of medical education.
Together with the Helsinki University Hospital (HUS) and the Helsinki Institute of Life Sciences (HiLIFE), the Faculty of Medicine, University of Helsinki, constitutes the Academic Medical Center Helsinki (AMCH). This medical center has been very successful in international comparisons, ranking among the top 10 medical campuses in Europe and among the top 50 globally.
Due date
08.10.2020 23:59 EEST
6.9.2020 | Avoimet työpaikat
https://www.helsinki.fi/en/open-positions/postdoctoral-researcher-in-statistical-human-genetics
The University of Helsinki is an international scientific community of 40,000 students and researchers. It is one of the leading multidisciplinary research universities and ranks among the top 100 international universities in the world.
The Institute for Molecular Medicine Finland (FIMM) is an international research unit focusing
on human genomics and personalised medicine at the Helsinki Institute of Life Science (HiLIFE) of the University of Helsinki – a leading Nordic university with a strong commitment to life science research. As part of Academic Medical Center Helsinki in Meilahti campus FIMM collaborates locally with the Faculty of Medicine, Helsinki University Hospital and National Institute for Health and Welfare. FIMM is part of the Nordic EMBL Partnership for Molecular Medicine, composed of the European Molecular Biology Laboratory (EMBL) and the centres for molecular medicine in Norway, Sweden and Denmark, and the EU-LIFE Community.
FIMM is currently seeking
Postdoctoral Researcher in Statistical Human Genetics
The Data Science and Genetic Epidemiology Lab (https://www.dsgelab.org/) lead by Dr. Andrea Ganna is interested in the development or application of methods to translate genetic discovery efforts into public health-relevant measures. In our group, we integrate electronic health records with genetic information from large biobank-based studies (e.g. https://www.finngen.fi/en). Our team includes experts in human genetics, epidemiology, and machine learning and we have recently launched the COVID19 Host Genetic Initiative (https://www.covid19hg.org/), to study the genetic determinants of COVID19 severity.
Our lab is based at FIMM and at Massachussets General Hospital/Harvard Medical School and affilitated with the Broad Institute. The candidate would be able to work periodically in both locations, if necessary. FIMM also provides excellent training opportunities for postdoctoral researchers through the FIMMPOD postdoctoral program.
Qualification and requirements: We are looking for future research leaders to work with an unprecedented amount of health information (diagnoses, medications, socio/demographic information, etc.) from millions of individuals in combination with biobank-based genetic data. The candidate will develop and pilot cutting edge approaches that leverage this data to elucidate the biological basis of disease and translate these findings into relevant public-health intervention. The successful candidate should prove a solid understanding of statistical genetics methods, including genome-wide association studies, Mendelian randomization, polygenic scores, and family-based designs. Understanding of epidemiological design and measures is considered a plus.
The candidate should hold a Ph.D. in the field of genetics, statistics, mathematics, computational sciences or genetic epidemiology. The ideal candidate shows scientific independence, has publishing experience, and an aptitude towards developing novel techniques. Together with the PI, he/she is jointly responsible for coordinating projects and supervising PhD students.
Contract & salary:. The job is for a fixed-term of 2 years with a possibility of extension for additional two years. A trial period of 6 months will be applied. The starting salary will be ca. 3300 – 3800 euros/month, depending on the appointee’s qualifications and experience and including a salary component based on personal performance. Standard Finnish pension benefits and occupational health care are provided for University employees.
Finland is a member of the EU, has high quality free schooling (also in English), generous family benefits and healthcare, and was recently ranked as the best country in the world for expat families and in the world’s top ten most livable cities. Finland and the Helsinki region possess top expertise in sciences in terms of a vibrant talent pool, leading research, strong support services and functioning collaboration networks. For more information about working at the University of Helsinki and living in Finland, please see https://www.helsinki.fi/en/university/working-at-the-university.
Given the current COVID19 pandemic we will also consider candidates that want to work mostly remotely.
How to apply: The application should include (i) CV, (ii) a publication list, (iii) a one- page statement of research interests and motivation for applying for this position and (iv) contact information of at least two reference persons who have agreed to provide a written statement on behalf of the applicant.
To apply, please submit the application through the University of Helsinki electronic recruitment system by clicking on Apply for job. Internal applicants (i.e., current employees of the University of Helsinki) please submit your applications through the SAP HR portal. Please apply no later than 30 September 2020.
For further information about the position, please visit our website at https://www.dsgelab.org/ or visit https://www.helsinki.fi/en/hilife-fimm or contact Andrea Ganna (aganna@broadinstitute.org). For questions regarding the recruitment process, please contact HR Specialist Anu Roine (anu.roine@helsinki.fi). Technical support regarding the recruitment system: rekrytointi@helsinki.fi.
Due date
30.09.2020 23:59 EEST
6.9.2020 | Avoimet työpaikat
https://www.helsinki.fi/en/open-positions/postdoctoral-researcher-in-biological-network-modelling
A postdoctoral position is available at the Faculty of Medicine, University of Helsinki, Finland to work in the research group of Dr. Jing Tang (https://www.helsinki.fi/en/researchgroups/network-pharmacology-for-preci…). The position is part of an Academy of Finland’s research project that aims to do network pharmacology modeling to provide the mechanism of action of drugs and drug combinations for a systems-level understanding of cancer. The Tang group combines computational methods to offer improved efficiency methods to identify more effective cancer treatments for personalized medicine. The Tang laboratory is based at Research Program in Systems Oncology (ONCOSYS) (https://www.helsinki.fi/en/researchgroups/research-program-in-systems-on…) at the Meilahti biomedical campus.
Role description:
We are seeking at least one postdoctoral researcher to work on the computational methods to develop network pharmacology models for predicting drug combinations. The project is focused on strategies for predicting potential drug combination and patient subclasses by constructing multipartite networks using drug response data. The primary goal of the project is to analyse drug sensitivity datasets to exploit drug-target interaction data to explore the biological mechanism of drugs. A key aim of the work is to propose drug combination regimens focusing on patient-derived drug response data along with the providing a biochemical and biophysical understanding of a drug combination. Hematological malignances and ovarian cancer are the available datasets for this project. The post holder will be responsible for planning and conducting computational research within the project under the supervision of Dr. Mohieddin Jafari, and Prof. Jing Tang.
The ability to work well within a collaborative team is critical for this position. You will work with unique datasets derived from large-scale experiments associated with a diverse range of projects in pharmacology and molecular biology. Salary will be commensurate with qualifications and experience based on the University guidelines. The full-time position start Jan 2021. A six-month trial period will be applied.
Key requirements:
We are seeking a creative and highly motivated individual with primary interest in network science and biomedical data mining. Candidates should have a PhD in bioinformatics, computational biology, statistics, computer science or other related disciplines. The ideal candidate will have experience in at least one of the aforementioned areas, and a strong interest in the others. Previous experience with biological networks, omics datasets, and expertise in related statistics and modelling are considered an advantage. Solid skills in scripting/programming (preferably R and Python) are essential prerequisites for this position. Excellent communication and presentation skills in English, good organisational skills, troubleshooting expertise and the ability to work effectively to tight deadlines are desirable.
Appointment details:
The position is available from October 2020 onwards, and can be started later upon agreement. It is a two-year fixed-term position, with a possibility of extension. Trial period of 6 months will be applied. The salary will be based on level 5 of the demands level chart for teaching and research personnel in the salary system of Finnish universities. In addition, the appointee will be paid a salary component based on personal performance with the overall starting salary amounting to approximately 3300-3600 EUR per month, depending on the qualifications and previous relevant research experience of the candidate.
Application details:
Please submit your application via the University of Helsinki Recruitment System by clicking the ‘Apply for the position button’ below. Internal applicants (i.e. current employees of the University of Helsinki) should submit their applications through the SAP HR portal. If you need support with the recruitment system, please contact recruitment@helsinki.fi.
Please attach the following documents to your application as a single PDF file:
– CV (including publications)
– Cover letter (maximum 1 page) that details your past experience and motivation for applying to the post.
– At least two recommendation letters with the contact details
The deadline for applications is September 30th 2020. Interviews will be conducted either in person or online. For more information on the position, please contact Dr. Mohieddin Jafari (mohieddin.jafari(at)helsinki.fi) and Prof. Jing Tang (jing.tang(at)helsinki.fi).
The University of Helsinki (UH), founded in 1640, is a vibrant scientific community of 40,000 students and researchers. It is one of the leading multidisciplinary research universities and ranks among the top 100 international universities in the world. It is currently investing heavily in life sciences research. UH offers comprehensive services to its employees, including occupational health care and health insurance, sports facilities, and opportunities for professional development.
Together with the Helsinki University Hospital (HUS) and the Helsinki Institute of Life Sciences (HiLIFE), the Faculty of Medicine, University of Helsinki, constitutes the Academic Medical Center Helsinki (AMCH). This medical center has been very successful in international comparisons, ranking among the top 10 medical campuses in Europe and among the top 50 globally.
Research Program in Systems Oncology (ONCOSYS) consists of basic, translational and clinical researchers who use cutting-edge measurement technology, patient data and AI methods in cancer research and oncology. The overall objective of ONCOSYS is to understand the underlying causes of cancer progression or treatment resistance, and to develop effective diagnostic, prognostic and therapeutic approaches.
Due date
30.09.2020 23:59 EEST
6.9.2020 | Avoimet työpaikat
https://www.helsinki.fi/en/open-positions/postdoctoral-fellow-in-computational-oncology
Join the Systems Biology of Drug Resistance in Cancer research group (https://www.helsinki.fi/en/researchgroups/systems-biology-of-drug-resist…) in University of Helsinki, Finland as
POSTDOCTORAL FELLOW IN COMPUTATIONAL ONCOLOGY
to discover combination therapies to overcome chemotherapy resistance in ovarian cancer. We have collected one of the largest high-quality data set that consists of WGS, bulk RNA-seq, whole-genome DNA methylation, ctDNA, single-cell RNA-seq or single-cell proteomics data from >1000 samples taken from 200 patients before and after chemotherapy within pan-Europe HERCULES (https://project-hercules.eu/) project. Complete and curated clinical data offers various data mining and integration opportunities in addition to the sequencing data. Our network enables validation of computational results and as well as translation of the validated results to clinic.
We expect:
• Strong methodological expertise. For example, in fields of statistics, applied mathematics, engineering or bioinformatics.
• Demonstrated track record of research experience in relevant subject areas, such as multivariate data analysis, machine learning, or mathematical modelling.
• Ability to both conduct research independently and work in collaborative multidisciplinary projects
• Good knowledge of English, both written and spoken
• Basic understanding of cancer biology is considered as an advantage
We offer:
• Excellent data, mentoring and infrastructure to conduct science at the highest level.
• A postdoctoral position for 3 years with a possibility for extension.
• A salary based on experience. Starting salary for a recently graduated postdoc is approx. 3500€
• an international multidisciplinary research environment with state-of-the-art facilities and computational resources
• occupational health services, flexible working hours, and excellent sports facilities, among other benefits of working for the biggest and highest ranking university in Finland
Work environment
The Systems Biology of Drug Resistance in Cancer research group is part of the cross-disciplinary Systems Oncology research program (https://www.helsinki.fi/en/researchgroups/research-program-in-systems-on…) at the Faculty of Medicine in University of Helsinki, Finland. The medical center ranks at the top 10 medical campuses in Europe and among the top 50 globally.
Application
Apply at latest on 30.9.2020. Application should include a short cover letter describing your areas of expertise and motivation, CV and list of publications. The application, together with the required attachments, must be submitted through the University of Helsinki electronic recruitment system by clicking on ’Apply for the position’ link. Internal applicants must submit their applications through the SAP HR portal.
Further information is available from the group leader, professor Sampsa Hautaniemi, sampsa.hautaniemi(at)helsinki.fi, Tel. +358 50 336 4765.
The University of Helsinki (UH), founded in 1640, is a vibrant scientific community of 40,000 students and researchers. It is one of the leading multidisciplinary research universities and ranks among the top 100 international universities in the world. It is currently investing heavily in life sciences research. UH offers comprehensive services to its employees, including occupational health care and health insurance, sports facilities, and opportunities for professional development.
Together with the Helsinki University Hospital (HUS) and the Helsinki Institute of Life Sciences (HiLIFE), the Faculty of Medicine, University of Helsinki, constitutes the Academic Medical Center Helsinki (AMCH). This medical center has been very successful in international comparisons, ranking among the top 10 medical campuses in Europe and among the top 50 globally.
Due date
30.09.2020 23:59 EEST
6.9.2020 | Avoimet työpaikat
https://www.helsinki.fi/en/open-positions/doctoral-student-research-assistant-in-mitochondrial-biology-and-signalling
The University of Helsinki as research-oriented university offers a stimulating and international environment. The Faculty of Medicine of the University of Helsinki, together with Helsinki University Central Hospital, The Helsinki Institute of Life Science, and the Institute for Molecular Medicine Finland forms the Academic Medical Center Helsinki. This medical campus ranks among the 10 best medical centers at European level and the 50 best centers in the world. More info on the Faculty or Medicine and AMCH can be found here:
https://www.helsinki.fi/en/faculty-of-medicinehttps://www.helsinki.fi/en/meilahti-campus
Faculty of Medicine, Jackson laboratory, invites applications for a position of
Doctoral Student / Research Assistant in mitochondrial biology and signalling
for a fixed-term
The focus of the lab is to unravel fundamental signalling pathways and mechanisms controlling mitochondrial function. We are particularly interested in how mitochondria adapt signalling to metabolic cues in models of dysfunction including primary mitochondrial patient cell lines, cancer and associated disorders. We aim to exploit this knowledge on basic principles of mitochondrial signalling and subsequent metabolic susceptibilities in cellular models to help devise novel treatments of diseases that stem from misregulated mitochondrial function.
In this role the candidate will have the unique opportunity to drive an exciting project addressing limiting metabolic pathways in models of mitochondrial dysfunction by genome-wide CRISPR screening and mitochondrial structural analysis. The successful candidate will have access to a wide range of methodologies with work consisting in preparation of cell models, construction of libraries, and analysis of metabolic, proteomic and microscopic data at the cellular level.
We are looking for a highly motivated independent researcher with prime analytical skills driven by a passion for science. We expect you to formulate your own hypotheses, propose experimental design to address them, and take advantage of the laboratory and research community’s intellectual and skill resources to advance the knowledge of the field. The appointee is expected to publish in top-level international peer reviewed scientific journals. In addition, she/he is also expected to potentially take part on the other research tasks such as ones related to ongoing studies and preparation of grant applications. The specific responsibilities will vary according to the level of expertise of the candidate.
The ideal candidate has an extensive background in standard molecular cell biological methods, ideally encompassing genetic and microscopic techniques and/or bioinformatics (NGS data). Expertise in biochemistry and molecular biology is a pre-requisite for this position. Additional expertise for research projects involving human subjects, primary cell culture would be highly desirable. The ideal candidate is an adaptable team-player and has excellent communication and organizational skills and a strong command in written and spoken English and should be familiar with the constraints related to translational research.
This position will provide multiple opportunities for collaborations with potential lab visits abroad and cross-disciplinary scientific exchange, where the candidate will receive extensive training in cutting-edge technology. An aptitude to drive and maintain intra and inter team collaborations will be highly appreciated. In return, the candidate is offered access to an extensive variety of methodology and advanced techniques, appropriate supervision and help in career development.
More information about the lab, including the latest research and news, can be found here:
http://www.jacksonlab.org
The DL for applications has been extended, all applications will be taken into consideration.
The position is initially limited to 2 years with a possibility of extension starting from September 2020. The contract of employment includes a probationary period of 6 months. Salary will be based on the Universities salary scheme for teaching and research personnel composed of both task specific and personal performance components.
The position will remain open until a suitable candidate will be recruited.
Please submit: CV, list of publications, motivation letter including a description of your research interests, and the names and telephone numbers of at least two referees.
Please submit your application, together with the required attachments, through the University of Helsinki electronic recruitment system by clicking on the ‘Apply for job’ button. Internal applicants (i.e., current employees of the University of Helsinki) submit their applications through the SAP HR portal.
For further information, please contact Christopher B. Jackson, Ph.D., docent:
christopher.jackson(at)helsinki.fi
Due date
30.09.2020 23:59 EEST
6.9.2020 | Avoimet työpaikat
https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=17&id=00009619&lang=en
The University of Eastern Finland, UEF, is one of the largest multidisciplinary universities in Finland. We offer education in nearly one hundred major subjects, and are home to approximately 15,500 students and 2,700 members of staff. We operate on two campuses in Joensuu and Kuopio. In international rankings, we are ranked among the leading universities in the world.
The Faculty of Science and Forestry operates on the Kuopio and Joensuu campuses of the University of Eastern Finland. The mission of the faculty is to carry out internationally recognised scientific research and to offer research-education in the fields of natural sciences and forest sciences. The faculty invests in all of the strategic research areas of the university. The faculty’s environments for research and learning are international, modern and multidisciplinary. The faculty has approximately 3,800 Bachelor’s and Master’s degree students and some 490 postgraduate students. The number of staff amounts to 560. http://www.uef.fi/en/lumet/etusivu
We are now inviting applications for
a Postdoctoral Researcher / Project Researcher (molecular mechanisms of fertilization and cryptic female choice in humans), Department of Environmental and Biological Sciences, Joensuu and/or Kuopio Campus
We are seeking a motivated Postdoctoral/Project Researcher for our project “Towards molecular-level understanding of fertilization and sexual selection” (funded by the Academy of Finland, more information from research: https://gamcomgroup.wordpress.com/).
Fertilization is one of the most complex and enigmatic biological processes, which severely hinders our understanding about reproduction, evolution and beginning of life. It has traditionally been assumed that fertilization is a completely unbiased process, leading to random fusion of gametes. Against this assumption, our recent findings have indicated that gametes often combine non-randomly, which bias fertilization towards particular (compatible) reproductive partners (see: http://dx.doi.org/10.1098/rspb.2018.0836 and http://dx.doi.org/10.1098/rspb.2020.1682). However, the molecular-level mechanisms of this gamete-level sexual selection (cryptic female choice) have remained unclear. The primary aim of our research is to clarify these mechanisms in humans and this way also gain better understanding of the mechanistic basis of fertilization and infertility.
The Postdoctoral/Project Researcher will participate in experimental research that aims to clarify these mechanisms in humans. Depending on the expertise of the researcher, the duties can include either:
1) Molecular and/or immunological analyses (e.g. RNA sequencing, human leucocyte antigen analyses, and mass spectrometry of reproductive proteins), 2) sperm motility and chemotaxis measurements, or 3) determination of female-induced physiological changes in sperm. The researcher’s tasks also include data analysis and reporting of the results in scientific journals.
The applicant is expected to have good skills in written and spoken English. Earlier experience in laboratory work, relevant methods in molecular biology (e.g. RNA seq, other next-generation sequencing methods or proteomics) and cell biology (e.g. sperm motility or viability analyses, ELISA assays or flow cytometry) will be considered a benefit for the applicant. If you have any of these skills, please indicate that in the accompanying CV and/or motivation letter (see below).
The person to be appointed as Postdoctoral/Project Researcher is expected to hold a doctoral degree from an applicable field. If the employee has been awarded his or her doctoral degree less than five years ago, the post will be one of a Postdoctoral Researcher. If the doctoral degree has been awarded more than five years ago, the post will be one of a Project Researcher. In this context, the five years refer to a net period of time, which does not include maternity leaves, parental leaves, or military service, etc.
English may be used as the language of instruction and supervision in this position.
The position is filled for a fixed term for two years starting from 1.10.2020 or as agreed (starting at the latest 1.1.2021). The position will be filled for a fixed term due to it pertaining to a specific project (positions of Postdoctoral Researcher shall always be filled for a fixed term, UEF University Regulations, Section 31).
The salary of the Postdoctoral Researcher or Project Researcher position is determined in accordance with the salary system of Finnish universities and is based on level 5 of the job requirement level chart for teaching and research staff (2 967,84 €7/month). In addition to the job requirement component, the salary is supplemented by a personal performance component, which can be a maximum of 50% of the job requirement component.
For further information on the position, please contact: Associate professor Jukka Kekäläinen, tel.+358 29 445 1004, email: jukka.s.kekalainen[a]uef.fi. For further information on the application procedure, please contact: Human Resources Secretary Sara Keronen, email: sara.keronen[a]uef.fi, tel. +358 29 445 8302.
A probationary period is applied to all new members of the staff.
The electronic application should contain the following appendices:
– CV
– List of publications
– Copies of the applicant’s academic degree certificates / diplomas, and copies of certificates / diplomas relating to the applicant’s language proficiency, if not indicated in the academic degree certificates/diplomas
– Motivation letter (max. two pages). In the letter, please indicate why you are interested in this research project and why you would be a suitable person for this position.
The application needs to be submitted no later than 23.9.2020 (by 24.00 hours Finnish time) by using the electronic application form.