Faculty of Medicine, Barborič laboratory, invites applications for a position of
Doctoral Researcher
in the field of Controlling Gene Transcription by Cyclin-dependent Kinases and their Targeting in Cancer for a fixed-term.
The University of Helsinki is a research-oriented university which offers a stimulating and international environment. The Faculty of Medicine of the University of Helsinki, together with Helsinki University Central Hospital, The Helsinki Institute of Life Science, and the Institute for Molecular Medicine Finland forms the Academic Medical Center Helsinki. This medical campus ranks among the 10 best medical centers at European level and the 50 best centers in the world. More info on the Faculty or Medicine and AMCH can be found here: https://www.helsinki.fi/en/faculty-of-medicine and https://www.helsinki.fi/en/meilahti-campus
The lab’s mission is to unravel fundamental mechanisms that control the elongation phase of transcription by RNA polymerase II (Pol II) in normal and disease states. We are particularly interested in essential and biomedically important transcriptional cyclin-dependent kinases (tCDKs) that trigger release of Pol II from promoter-proximal pausing and facilitate productive Pol II elongation along genes. We aim to exploit the knowledge on basic principles of gene regulation to help devise novel treatments of many diseases that stem from misregulated gene transcription programs. More information about the lab, including the latest research and news, can be found here: https://www.helsinki.fi/en/researchgroups/center-for-gene-regulation
We are looking for a creative thinker with strong analytical skills and a passion for science. We expect you to formulate your own hypotheses, propose experimental design to address them, and take advantage of the laboratory/research community’s intellectual and skill resources to advance the knowledge of the field. The competitive candidate should hold an MSc degree in molecular biology, biochemistry, biotechnology or related fields. Expertise in biochemistry and molecular biology is a pre-requisite for the position. In addition, we appreci-ate fluency in the analysis of NGS data. Strong command in written and spoken English is required.
The successful candidate will receive training in biochemical, molecular biology and cell line-based functional assays, as well as cutting-edge systems biology methods, such as CRISPRi and nascent transcriptomics methods. The training will be furthered by research visits as part of our collaborations with a network of well-regarded laboratories around the globe. Current projects in the lab funded by the 4-year Research Council of Finland grant, 3-year Sigrid Juselius Foundation grant and Cancer Foundation Finland grant, Sigrid Juselius Foundation revolve around fundamental biology of tCDKs and their combinatorial targeting in cancer.
The salary of the selected candidate will be based on the University’s salary scheme for teaching and research personnel composed of task specific and personal performance components. A trial period of six months will be applied.
The University of Helsinki offers comprehensive services to its employees, including occupational health care and health insurance, unemployment and pension fund, a generous holiday package, sports facilities, and opportunities for professional development: https://www.helsinki.fi/en/about-us/careers.
The appointee is expected to reside in Finland while employed by the University of Helsinki. International staff is supported in relocating to Finland: https://www.helsinki.fi/en/about-us/careers/welcome.
Please submit your application, together with a motivation letter including a summary of your research interests, CV, and two letters of reference, through the University of Helsinki electronic recruitment system by clicking on the ’Apply now’ button.
Internal applicants (i.e., current employees of the University of Helsinki) submit their applications by using the Employee Login button.
The University of Helsinki welcomes applicants of any gender, linguistic and cultural background or minority group.
The closing date for application is September 9th, 2024. The shortlisted candidates will be notified about the interview shortly afterwards.
For further information, please contact Matjaž Barborič, Ph.D.; matjaz.barboric(at)helsinki.fi
Recent publications:
Wang Z et al. (2023) Inhibition of CDK12 elevates cancer cell dependence on P-TEFb by stimulation of RNA polymerase II pause release. Nucleic Acids Res 51(20):10970-10991
Wang Z et al. (2023) P-TEFb promotes cell survival upon p53 activation by suppressing intrinsic apoptosis pathway. Nucleic Acids Res 51(4):1687-1706
Bugai A et al. (2019) P-TEFb activation by RBM7 shapes a pro-survival transcriptional response to genotoxic stress. Molecular Cell 74(2): 254-267
The University of Oulu is a multidisciplinary, international research university, with about 3,600 employees who produce new knowledge based on high-standards research and provide research based education to build a more sustainable, smarter, and more humane world. The University of Oulu community has about 17,000 people in total. Our northern scientific community operates globally and creates conditions for the emergence of innovations.
We are now seeking for a highly motivated and talented
Doctoral Researcher in Computational Cancer Biology
to join the education pilot in precision cancer medicine (iCANDOC) in the research group of Associate Professor Valerio Izzi at the University of Oulu.
In this position, you will participate in the national 1000 doctorates pilot programme which supports the completion of a doctoral degree within three years. As a partner in the programme, the University of Oulu is dedicated to ensuring you have a carefully planned and guided doctoral research experience which will be tailored to support your career plans, enabling you to continue into demanding expert positions in the changing job markets in industry, the public sector and academia.
Job Description
Cancer initiation and progression depend on the interplay between heterogeneous tumor cells and the surrounding tumor microenvironment (TME), consisting of various types of stromal cells and the extracellular matrix (ECM). Our research focuses on understanding the composition and roles of tumor ECM compartments (niches) in modulating cancer cell phenotypes and fates, cancer progression and therapy resistance, at the systems biology level.
The Izzi group (https://github.com/Izzilab) is a leader in developing computational tools for the analysis of ECM in high-dimensional, multi-modal data. As a doctoral researcher in our group, you will participate in developing machine learning/AI algorithms to deconvolute the connections between ECM niches and functional cancer cell states at the single-cell, spatial, and proteomics level. Expectedly, these algorithms will help identifying druggable ECM targets in cancer, which will be validated in our cellular and in vivo cancer models.
As a member of our group, you will access a network of numerous national and international collaborations, which will expose you to state-of-the-art methodologies for ECM research and offer rich opportunities for internships, mobility, and further career development after completion the PhD in three years. The Izzi group is part of the ECM-Hypoxia research unit with six internationally strong research groups.
Who are you?
In order to succeed and enjoy the position, we expect from you:
Master’s or equivalent degree in bioinformatics, biostatistics, data analysis, molecular and cell biology, biochemistry, biomedicine, medicine, or related fields
Excellent command of R and/or Python and advanced knowledge of machine learning and deep learning
Experience with big data analysis (bulk and single-cell RNASeq, proteomics, spatial methods are considered an advantage)
Basic knowledge of cancer cell biology
Fluent in written and spoken English language
Excellent communication and teamwork skills
Full dedication on the research project and ability to meet project deadlines
We also appreciate
Previous experience in teaching
Experience with Shinyapp development
Experience with cell culture and wet lab-based cancer research projects
Please see also the requirements of the University of Oulu Graduate School (UniOGS).
Qualification Requirements
The chosen doctoral researchers will also be expected to apply for doctoral study rights at the University of Oulu Graduate School. Eligibility for study rights will be evaluated during the job application process. We are looking for excellent candidates who must fulfill the following criteria:
Must hold a master’s degree or equivalent degree (e.g. licentiate) in bioinformatics, biostatistics, data analysis, molecular and cell biology, biochemistry, biomedicine, medicine, or related fields
Undergraduate students are eligible to apply provided their Master’s or equivalent degree is finished by 1.1.2025
Must have achieved a good grade in their degree (i.e. at least 60 % of the maximum grade in both taught courses and the master’s thesis)
Must be able to demonstrate English language skills that are sufficient to follow doctoral studies.
What We Offer
A dynamic research environment which promotes personal and professional growth as a scientist The support of two experienced, enthusiastic and multidisciplinary research teams.
A low hierarchy structure focused on teamwork and constant discussion flow.
An inspiring international research atmosphere and smooth entry to national and international ECM research networks.
Structured, interdisciplinary doctoral training.
Work that matters and a workplace that promotes flexibility and work-life balance. Read more about working with us.
Wellness benefit ePassi covering sport, culture and well-being. Read more about other staff benefits.
Our Buddy Programme and Spouse Network support you and close-ones in settling into Oulu.
We have a HR Excellence in Research -quality label which is a recognition awarded by the European Commission for the development of researchers’ working conditions and careers.
Finland is one of the most livable countries in the world, with a high quality of life, safety, excellent education system, and competitive economy. Read more about living in Oulu.
Position and salary
Doctoral researchers selected in the pilot programme will by default be offered a three-year (36 month) fixed-term full-time employment contract by University of Oulu. These positions are available for highly motivated and talented researchers wishing to undertake and complete training for a research-focused doctoral degree, starting 1.1.2025 at the earliest. The selected applicants are expected to start their project no later than 1.2.2025. A six-month trial period is applied in the position.
The salary of the selected doctoral researchers will be paid monthly. The salary will be based on the levels 2-4 of the demand level chart for teaching and research staff of Finnish universities. In addition, a salary component based on personal work performance will be paid (maximum of 50 % of the job-specific component). Starting gross salary will be approx. 2500-2800 € per month (before taxes).
The employment contracts are based on a total working time of 1612 hours per year, which gives the doctoral researchers freedom to plan their working hours.
How To Apply
Applications, together with all relevant enclosures, should be submitted using the electronic application form by 30.9.2024 (23:59 Finnish local time). The application should be written in English and include the following:
Certificates/Diplomas Scanned copy of the original relevant Master’s degree certificates and transcript of records and, when necessary, official translations to Finnish or English.
A motivation letter (max. 2 pages) summarizing applicant’s professional experience and expertise and describing why the applicant is a good fit for this position. Also, information on personal research interests, experience and career plans are valuable to provide here.
Curriculum vitae (max. 2 pages). A recommended CV template can be found on the Finnish National Board on Research Integrity. At the end of the CV, the applicant must include a list of peer-reviewed scientific publications with full reference details. The number of pages of the publication list doesn’t concur to the max. 2 page-limit of the CV.
Research plan (max. 4 pages) The research plan should mostly contain information about the planned use of algorithms (which? why? how?) to tackle the research questions mentioned in the Job Description section. The ability to envision how the use of such methodologies could advance the study of ECM niches in cancer is considered an advantage. Applicants to this position are encouraged to contact Prof. Valerio Izzi and Dr. Ritva Heljasvaara before and/or while preparing this document.
A valid certificate or other demonstration of language proficiency.
Only applications containing all relevant appendices and submitted through the online recruitment system will be considered. Applications received after the call deadline will not be considered.
We welcome applicants from all backgrounds, including people of different ages, genders, and linguistic, cultural, or minority groups.
Evaluation
Applications will be evaluated according to the suitability of the candidate and the proposed research plan for the job description, competence, motivation, commitment and career plan. Applicants with excellent records in these areas will be invited to an online interview where the above criteria as well as professional experience and language proficiency will be reviewed. All candidates will be scored jointly by Prof. Valerio Izzi and Dr. Ritva Heljasvaara and the best candidate will be offered the position. All applicants will be informed at the different steps of the process.
Further information
For further information, please contact Valerio Izzi (valerio.izzi@oulu.fi) or Ritva Heljasvaara (ritva.heljasvaara@oulu.fi)
Faculty of Medicine, Barborič laboratory, invites applications for a position of
Postdoctoral Researcher
in the field of Controlling Gene Transcription by Cyclin-dependent Kinases and their Targeting in Cancer for a fixed-term.
The University of Helsinki is a research-oriented university which offers a stimulating and international environment. The Faculty of Medicine of the University of Helsinki, together with Helsinki University Central Hospital, The Helsinki Institute of Life Science, and the Institute for Molecular Medicine Finland forms the Academic Medical Center Helsinki. This medical campus ranks among the 10 best medical centers at European level and the 50 best centers in the world. More info on the Faculty or Medicine and AMCH can be found here: https://www.helsinki.fi/en/faculty-of-medicine and https://www.helsinki.fi/en/meilahti-campus
The lab’s mission is to unravel fundamental mechanisms that control the elongation phase of transcription by RNA polymerase II (Pol II) in normal and disease states. We are particularly interested in essential and biomedically important transcriptional cyclin-dependent kinases (tCDKs) that trigger release of Pol II from promoter-proximal pausing and facilitate productive Pol II elongation along genes. We aim to exploit the knowledge on basic principles of gene regulation to help devise novel treatments of many diseases that stem from misregulated gene transcription programs. More information about the lab, including the latest research and news, can be found here: https://www.helsinki.fi/en/researchgroups/center-for-gene-regulation
We are looking for a creative thinker with strong analytical skills and a passion for science. We expect you to formulate your own hypotheses, propose experimental design to address them, and take advantage of the laboratory/research community’s intellectual and skill resources to advance the knowledge of the field. The competitive candidate should hold a PhD degree in molecular biology, biochemistry, biotechnology or related fields. Expertise in biochemistry and molecular biology is a pre-requisite for the position. In addition, we appreciate fluency in the analysis of NGS data. Strong command in written and spoken English is required.
The successful candidate will receive training in a comprehensive set of biochemical, molecular biology and cell line-based functional assays, as well as cutting-edge systems biology methods, such as CRISPRi and nascent transcriptomics methods. The training will be furthered by research visits as part of our collaborations with a network of well-regarded laboratories around the globe. Current projects in the lab funded by the 4-year Research Council of Finland grant, 3-year Sigrid Juselius Foundation grant and Cancer Foundation Finland grant, Sigrid Juselius Foundation revolve around fundamental biology of tCDKs and their combinatorial targeting in cancer.
The salary of the selected candidate will be based on the University’s salary scheme for teaching and research personnel composed of task specific and personal performance components. A trial period of six months will be applied.
The University of Helsinki offers comprehensive services to its employees, including occupational health care and health insurance, unemployment and pension fund, a generous holiday package, sports facilities, and opportunities for professional development: https://www.helsinki.fi/en/about-us/careers.
The appointee is expected to reside in Finland while employed by the University of Helsinki. International staff is supported in relocating to Finland: https://www.helsinki.fi/en/about-us/careers/welcome.
Please submit your application, together with a motivation letter including a summary of your research interests, CV, list of publications and two letters of reference, through the University of Helsinki electronic recruitment system by clicking on the ’Apply now’ button.
Internal applicants (i.e., current employees of the University of Helsinki) submit their applications by using the Employee Login button.
The University of Helsinki welcomes applicants of any gender, linguistic and cultural background or minority group.
The closing date for application is September 9th, 2024. The shortlisted candidates will be notified about the interview shortly afterwards.
For further information, please contact Matjaž Barborič, Ph.D.; matjaz.barboric(at)helsinki.fi
Recent publications:
Wang Z et al. (2023) Inhibition of CDK12 elevates cancer cell dependence on P-TEFb by stimulation of RNA polymerase II pause release. Nucleic Acids Res 51(20):10970-10991
Wang Z et al. (2023) P-TEFb promotes cell survival upon p53 activation by suppressing intrinsic apoptosis pathway. Nucleic Acids Res 51(4):1687-1706
Bugai A et al. (2019) P-TEFb activation by RBM7 shapes a pro-survival transcriptional response to genotoxic stress. Molecular Cell 74(2): 254-267
We are inviting applications for a total of 15 Doctoral Researchers to the doctoral programmes of the Faculty of Health Sciences. The positions will be hosted by the Faculty of Health Sciences on the Kuopio campus and will start on 1 January 2025 (or by the end of 2025 as agreed). Please find more information below, and submit your application by 26 August 2024.
Role and salary
Through this call for applications, you can apply for a Doctoral Reseacher position in the Doctoral Programme in Molecular Medicine (DPMM), which is an interdisciplinary doctoral training program with the purpose of training researchers as international experts in modern biomedicine. Molecular medicine studies the causes and mechanisms of origin of diseases on a molecular level and strives to find methods to treat and prevent these diseases. The research areas in DPMM are cardiovascular diseases, neurosciences, type 2 diabetes and obesity, stem cell research, inflammatory diseases, and cancer.
The duties of a Doctoral Researcher include conducting research related to their doctoral dissertation in accordance with their approved research proposal. The aim is to complete the doctoral degree in four years of full-time study, regardless of the funding source.
Doctoral Researcher positions are filled for a maximum of three years starting from 1 January 2025 (or by the end of 2025 as agreed). In fulfilling these tasks, previous Early-stage Researcher/Doctoral Researcher positions will be considered regardless of the funding source. A trial period is applied to new holders of a position. The position is filled for a fixed term due to doctoral dissertation work related to postgraduate studies.
The position of a Doctoral Researcher may be applied for either on a full-time or a part-time basis. Part-time Doctoral Researcher positions must be co-financed with some other funding source (for example, an external grant administered outside the university that can be combined with the employment contract or a part-time employment contract with another organisation), so that the total amount of funding enables the candidate to work full-time on their doctoral dissertation. Individual months as a Doctoral Researcher may also be applied for.
The salary of the post is based on the salary system for the teaching and research staff of Finnish universities. The salary consists of a job-related salary element and a personal salary element. In this position, the job-related salary element is based on level 2–4 (EUR 2,225.83 – 2,775.28/month) of the job requirement level chart, depending on the stage of the applicant’s doctoral research and postgraduate studies. In addition, a personal salary element is paid, which is 6-50% of the job-related salary element.
We expect you to
to be qualified to pursue postgraduate studies; you hold a relevant Master’s degree awarded by a university or by a university of applied sciences, or a relevant applicable study programme abroad which in the awarding country gives eligibility for the corresponding level of higher education,
have good skills in the English language,
meet the student admission criteria for the doctoral programme,
be planning or doing your first doctoral degree,
be a postgraduate student registered with the University of Eastern Finland or plan to complete your doctoral dissertation at the University of Eastern Finland.
In addition, the duration of your (full-time) doctoral research must not exceed four years by 31 December 2024.
We offer you
an interesting position in an international, creative, participatory and inclusive university community,
the opportunity for flexible multi-location work,
the staff benefits of the University of Eastern Finland, including comprehensive occupational health care, extensive provision of staff training, affordable lunch in our campus restaurants, and Sykettä sports services, a tax-free bike benefit.
How To Apply
Submit your application by using our electronic application form no later than 26 August 2024 by 24:00 (midnight) Finnish time (UTC+3). The Doctoral Researcher position must be applied for in the doctoral programme to which you have applied/will apply for a postgraduate study right at the University of Eastern Finland.
Please note that the applications must contain the following appendices in English (in pdf-format):
A curriculum vitae (Template for CV, www-page).
A publication list specifying the publications to be included in your doctoral dissertation, if not included in the curriculum vitae (Instructions for a list of publications, www-page).
A research proposal including a research funding plan describing the resources required and existing for the research as well as a brief description of the relevance/impact of the research. Persons who are already registered as postgraduate students must submit an updated research proposal, including a report on the progress of their doctoral research and the intended schedule for the completion of the doctoral research and the initiation of the pre-examination process. Max. 3 pages without references. (Instructions for a research plan, pdf).
A motivational letter (1 page), in which the applicant describes their motivation to pursue postgraduate studies and to conduct research.
A copy of the degree certificate and a transcript of academic records that prove the applicant’s eligibility for postgraduate studies if the person does not have an existing right to pursue postgraduate studies at the University of Eastern Finland.
Only applications that contain all appendices specified in the call will be evaluated and taken into account in the selection. Applications will be evaluated based on uniform criteria, utilising external experts.
The criteria: the quality, clarity, and innovativeness of the research proposal, the feasibility of the research proposal as a doctoral dissertation, the applicant’s evidence of previous research projects and the applicant’s motivation based on the motivation letter.
The evaluation may include an interview. The objective is for the faculty to decide on the candidates to be appointed to the positions by mid-November.
Questions?
healthpostgrad@uef.fi
Terveystieteiden tiedekunta toimii Itä-Suomen yliopiston Kuopion kampuksella. Tiedekunnassa koulutetaan lääkäreitä, hammaslääkäreitä, ravitsemusterapeutteja, farmaseutteja ja proviisoreja sekä muita keskeisiä asiantuntijoita terveydenhuollon eri aloille. Tiedekunta on hyvin tutkimusintensiivinen. Kansainvälisesti korkeatasoinen ja monitieteinen tutkimus kytkeytyy vahvasti yliopiston strategiassa tunnistettuihin tutkimusalueisiin. Tiedekunnassa on noin 3090 perustutkinto-opiskelijaa ja noin 580 jatko-opiskelijaa. Henkilökuntaa tiedekunnassa on 800.
Itä-Suomen yliopisto (UEF) on Suomen monialaisin tiedeyliopisto. Yliopistossamme työskentelee noin 3 200 työntekijää, ja yhteisöömme kuuluu noin 16 000 tutkinto-opiskelijaa ja 16 000 aikuisopiskelijaa. Kampuksemme toimivat Joensuussa ja Kuopiossa. Tutkimuksemme on useilla aloilla maailman kärkeä, ja tuotamme tutkittua tietoa avoimesti käytettäväksi ja kaikkien hyväksi. Tutustu yliopistoomme verkossa www.uef.fi. Tutustu myös yliopistoon työyhteisönä ja työnantajana sekä työntekijöidemme uratarinoihin.
QIAGEN has an exciting new vacancy for an Account Manager in Finland, preferably living in the Helsinki area. Our sales team work with Life Sciences customers, primarily within academia, to facilitate a customer-centric service and provide them with Sample to Insight solutions. We are looking for an Account Manager to drive and grow sales across the QIAGEN portfolio, supporting customers in the whole of Finland.
The Account Manager will be key in shaping and aligning customer requirements with the ideal QIAGEN solutions. You will be responsible for protecting, growing and proactively searching for new business within the territory for Life Sciences.
Key responsibilities:
– Maintain contact with existing customers as well as develop new customers in order to achieve or exceed sales objectives.
– Achieve or exceed objectives by actively selling to end users primarily at customer sites. Develop a working knowledge of current and potential activities that may affect revenues; Attend sales meetings.
– Regularly report and forecast relevant market figures for sales management and organise and support at seminars and conferences.
– Act as a champion for certain business areas.
– Utilize the CRM database to input and provide information that will increase effectiveness and aid sales.
Position Requirements
– Strong scientific background – ideally qualified to MSc level or higher in a Life Science subject with a proven aptitude for laboratory techniques. Knowledge in molecular biology. Sales experience within Life Science business is an advantage.
– Fluent Finnish and English essential, with excellent listening, verbal, and written communication skills at all business levels.
– Self-motivated with the ability to work in collaboration with field sales representatives and application specialists and with excellent organisational and time management skills.
– Willingness and availability to travel to visit customers up to 80% including occasional overnight travel. Travel will be mostly within Finland but also in Europe/Nordic regions for trainings and sales meetings; Driving license essential.
This position is home-based. However we have an office hub in Helsinki where the whole Finnish team meet regularly.
What we offer
At the heart of QIAGEN are our people who drive our success. We act with passion, always challenging the status quo to drive innovation and continuous improvement. We inspire with our leadership and make an impact with our actions. We create a collaborative, safe and engaging workplace which forms the basis for high performing individuals and teams. We drive accountability and entrepreneurial decision-making and want you to excel your growth and shape the future of QIAGEN.
QIAGEN is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, or disability.
Faculty of Biochemistry and Molecular Medicine, Disease Networks
The University of Oulu is a multidisciplinary, international research university, with about 3,600 employees who produce new knowledge based on high-standards research and provide research based education to build a more sustainable, smarter, and more humane world. The University of Oulu community has about 17,000 people in total. Our northern scientific community operates globally and creates conditions for the emergence of innovations.
We are now looking for a
Doctoral Researcher
to the education pilot in precision cancer medicine (iCANDOC)to join us in the Vainio group, Disease Network Research unit at the Faculty of Biochemistry and Molecular Medicine.
The Vainio group is a leader in the field of experimental organ/organoid biology and the team developed a panel of sophisticated tools to target complex tissue organization assembly mechanisms.
About the job
Cancer initiation and progression depend on the interplay between heterogeneous tumor cells and the surrounding tumor microenvironment (TME), consisting of various types of stromal cells and the extracellular matrix (ECM). All these events are known to associate to actions of cell secreted nanovesicles (extracellular vesicles (EVs)). Our research focuses on understanding the composition and roles of such tumor derived EVs by using in vivo and ex vivo models to develop novel cancer diagnostic and targeted therapeutic.
What we offer?
The support of an experienced and enthusiastic team of 15 people where you can share your expertise and grow as an expert.
We have a HR Excellence in Research -quality label which is a recognition awarded by the European Commission for the development of researchers’ working conditions and careers.
Finland is one of the most livable countries in the world, with a high quality of life, safety, excellent education system, and competitive economy. Read more about living in Oulu.
Who are you?
As a doctoral researcher in our group, you will participate to a team in developing EV based bioengineering technologies that aim to target drug loaded EVs to tumor cells, to eradicate them and also to provide noninvasive tumor eradication efficacy monitoring. To achieve these goals the doctoral researcher will take use of the kidney tissue engineering toolbox and the excellent infra structure to validate the therapeutic openings in preclinical models.
As a member of our group, you will access a network of multiple of national and international collaborations, which will expose you to state-of-the-art methodologies for EV research and offer cutting edge opportunities for internships, mobility, and further career development after completing the PhD in three years.
In order to succeed and enjoy the position, we expect from you:
Master’s or equivalent degree in molecular and cell biology, embryology, developmental biology, biochemistry, biomedicine, medicine, bioinformatics, data analysis, or related fields
Excellent capacity to work with cell culture, organoids and in vivo disease modelling with aims to translational medicine
Interest in applying cancer genetic and epigenetic/multi-OMICs data such as EV bioinformatics and applied AI analytics on experimental and clinical data single-EV, single cell RNASeq, proteomics, spatial methods are an advantage
Basic knowledge of cancer cell biology
Fluent in written and spoken English language
Excellent communication and teamwork skills
Full dedication on the research project and ability to meet project deadlines
Doctoral researchers selected in the pilot programme will by default be offered a three-year (36 month) fixed-term full-time employment contract by University of Oulu. These positions are available for highly motivated and talented researchers wishing to undertake and complete training for a research-focused doctoral degree, starting 1.1.2025 at the earliest. The selected applicants are expected to start their project no later than 1.2.2025. A six-month trial period is applied in the position.
The salary of the selected doctoral researchers will be paid monthly. The salary will be based on the levels 2-4 of the demand level chart for teaching and research staff of Finnish universities. In addition, a salary component based on personal work performance will be paid (maximum of 50 % of the job-specific component). Starting gross salary will be approx. 2500-2800 € per month (before taxes).
The employment contracts are based on a total working time of 1612 hours per year, which gives the doctoral researchers freedom to plan their working hours.
How to apply?
Applications, together with all relevant enclosures, should be submitted using the electronic application form by 30.9.2024 (23:59 Finnish local time). The application should be written in English and include the following:
Certificates/Diplomas Scanned copy of the original relevant master’s degree certificates and transcript of records and, when necessary, official translations to Finnish or English.
A motivation letter (max. 2 pages) summarizing applicant’s professional experience and expertise and describing why the applicant is a good fit for this position. Also, information on personal research interests, experience and career plans are valuable to provide here.
Curriculum vitae (max. 2 pages). A recommended CV template can be found on the Finnish National Board on Research Integrity. At the end of the CV, the applicant must include a list of peer-reviewed scientific publications with full reference details. The number of pages of the publication list doesn’t concur to the max. 2 page-limit of the CV.
Research plan (max. 4 pages) The research plan should mostly contain information about the planned use and expected value of EVs (which? why? how?) to tackle the research questions mentioned in the Job Description section. The ability to envision how the use of such methodologies could advance the study and use of EVs in cancer is considered an advantage. Applicants to this position are encouraged to contact Prof. Seppo Vainio and Adj. Prof. Anatoliy Samoylenko before and/or while preparing this document.
A valid certificate or other demonstration of language proficiency.
Only applications containing all relevant appendices and submitted through the online recruitment system will be considered. Applications received after the call deadline will not be considered.
We welcome applicants from all backgrounds, including people of different ages, genders, and linguistic, cultural, or minority groups.
Contact Information
For further information, please contact Professor Seppo Vainio (seppo.vainio@oulu.fi) or Adjunct Professor Anatoliy Samoylenko (anatoliy.samoylenko@oulu.fi)
The University of Eastern Finland is inviting applications for a Postdoctoral Researcher position on the Kuopio Campus. The position will be filled for a two-year term from 1 October 2024 onwards (or as agreed) with the option to extend for an additional 1–2-year. Please find more information below and submit your application by 5 August 2024.
Role and salary
The Cardiovascular Genomics Lab (Kaikkonen Lab) at the A.I. Virtanen Institute, University of Eastern Finland is seeking a highly motivated and skilled Postdoctoral Researcher. This position is part of an ERC-funded project entitled SECRET that aims to unravel the complex genetic and gene regulatory mechanisms underlying atherosclerotic cardiovascular disease (ASCVD).
The SECRET project focuses on exploring the functional impacts of specific ASCVD-associated cis-regulatory variants identified in GWAS studies. The project will initially screen how these variants influence gene regulation in key vascular cells—endothelial cells and smooth muscle cells. Following the identification of key regulatory variants, further experiments will manipulate these genes directly using CRISPR interference (CRISPRi) and CRISPR activation (CRISPRa) to observe the effects on broader gene expression patterns and cellular responses. The generated data will be used to identify convergences around gene regulatory networks, helping to uncover the mechanisms, functions, and pathways that underlie ASCVD risk.
The position is being offered as a 2-year appointment with a 1-2 year extension option. The position is filled for a fixed-term due to it pertaining to a specific project task. A probationary period is applied to all new members of the staff.
The salary of the position is determined in accordance with the salary system of Finnish universities. The salary comprises two components: a job-related salary element and a personal salary element. In this position, the job requirement level is based on levels 5-6 on the job requirement level chart for teaching and research staff. The personal salary element is 6–50% of the job-related salary element. Depending on the personal salary element, the salary will be approximately 3,500 -4,500 €/month.
Our requirements and expectations
We invite applications from talented individuals who are highly motivated and passionate about making a transformative impact in cardiovascular research.
Requirements
A Ph.D. or equivalent in a field relevant to the proposed project
Research Experience: Demonstrable experience in research, preferably within the field of cardiovascular research, genetics, genomics, biotechnology, molecular biology, bioinformatics or a closely related area.
Skills: Proficiency in high-throughput genomic methods and data analysis, genetic manipulation tools (e.g. CRISPR), and/or mammalian cell culture.
Publications: A strong track record of publications.
Communication: Excellent English communication skills, both written and oral.
Teamwork: Ability to work effectively as part of an interdisciplinary and international team.
Motivation: A passion for scientific research, problem-solving abilities, and a strong desire to contribute to the field of cardiovascular genomics.
Autonomy: Candidates should be capable of independent thought and decision-making, demonstrating an ability to lead projects from conception to completion.
Supervision experience: The candidate will have the opportunity to supervise MSc and PhD students
Expectations
Ability to work effectively as part of an interdisciplinary and international team.
A passion for scientific research, problem-solving abilities, and a strong desire to contribute to the field of cardiovascular genomics.
Your benefits
You will have access to the university’s staff benefits, including
opportunity for flexible multi-location work
extensive occupational health care
broad selection of staff training
staff discount on lunch in our campus restaurants, as well as on a range of other services
affordable sports services and tax-free bike benefit
Please read more in the Work at UEF section on our website.
You will have an opportunity to work in an interesting and meaningful role as part of our international, creative, participatory and inclusive academic community.
Enjoy your life in Finland! Known for its cleanliness, welfare know-how, modern technology and superb education system, Finland is an exotic and safe country to work in. Please visit the Life in Finland section on our website to learn more.
How to apply?
Submit your application by using our electronic application form no later than 5 August 2023 by 24:00 (midnight) Finnish time (UTC+3)
Please note that you must include the following appendices in your application
CV (Template for CV , www-page)
a list of publications (Instructions, www-page)
copies of your academic degree certificates / diplomas, and copies of certificates / diplomas relating to your language proficiency, if not indicated in the academic degree certificates/diplomas
motivation letter: A detailed letter explaining your interest in the project, how you believe you can contribute to our objectives, and why you consider yourself a strong fit for the role
Questions?
For further information on the position, please contact Professor Minna Kaikkonen-Määttä, tel. +358 29 445 4156, minna.kaikkonen@uef.fi
For further information on the application procedure, please contact HR Controller Tarja Salmi, tarja.salmi@uef.fi, +358 29 4458220 (out of office
The Faculty of Health Sciences operates at the Kuopio Campus of the University of Eastern Finland. The Faculty offers education in medicine, dentistry, nutrition and pharmacy, as well as in some other central fields of the health care sector. The Faculty is research-intensive, and its internationally recognised research activities are closely linked to the strategic research areas of the University. There are approximately 3 090 degree students and about 580 PhD students in the Faculty. The faculty has 800 staff members.
The University of Eastern Finland (UEF) is the most multidisciplinary university in Finland. Our university employs approximately 3,200 employees, and our community includes approximately 16,000 degree students and 16,000 adult education students. Our campuses are located in Joensuu and Kuopio. We represent the world’s cutting edge of research in many fields and produce research-based knowledge, which is made openly available to benefit everyone. Learn more about our university at www.uef.fi/en. Read also about UEF as a working community and employer and the career stories of our employees.
Canatu is a carbon nanomaterial developer creating the most advanced carbon nanotubes for industry-transforming products. The Canatu carbon nanotube (CNT) technology has been created with a unique process that ensures the required versatility and reliability for highly engineered solutions. Canatu partners with forerunner companies, together transforming products for better tomorrows with nano carbon. The company’s focus is in the automotive and semiconductor industries with the portfolio’s core spanning from ADAS heaters to 3D touch sensors and to EUV membranes. The experts at Canatu think big and create impacts on the tiniest scale – nano solutions for massive impact. Canatu’s headquarter is in Finland with sales offices in the US, Japan, and Taiwan. More information on www.canatu.com.
Canatu is further expanding operations and building a passionate team to drive our biosensor development and commercialization. Join us to develop the next-generation medical diagnostics solutions!
We are currently looking for an enthusiastic and highly competent
R&D Scientist, Medical Diagnostics
who will work as an engineering expert in our biosensor team. In this role, you will be contributing to the design, validation and assessment of biosensors and assays. This is a unique and exciting opportunity to join the company where we are passionate about solving world-scale problems with nanoscale innovations. The successful candidate has a passion for innovation, commitment to achieve, and is driven by curiosity. As a person, you strive in a fast-paced changing environment. In this position, you will report to the CTO.
Responsibilities:
Research and development of biosensors towards commercial applications
Surface chemistry modification for biosensor application
Sourcing and implementation of appropriate biorecognition elements, e.g., antibodies or aptamers, to meet the application requirements
Perform /analyze testing and verification data according to regulations and standards for manufacturing processes (e.g. cGMP and GPD)
Manage work packages and tasks
Write technical reports and documents
Our expectations for you:
Some experience in development of electrochemical or immuno-based biosensors and assays from academia or industry.
Knowledge of biosensors principles, design and basic characterizations including sensor stack related materials, e.g. capillary materials and membranes
Knowledge of biochemistry, immunochemistry, enzyme immobilization, DNA, and RNA chemistries
Hands-on experience
Good written and verbal communication skills in English
Ability to learn fast and work independently at the customer interface
Solid problem-solving skills, customer-oriented mindset and “can do” attitude
Good time management and interpersonal skills
MSc or PhD in chemistry, material science, biochemistry, electrical engineering, or some other similar degree in relevant field
What do we offer you?
At Canatu we have substantial growth prospects, and we are constantly seeking innovation. As a rapidly growing company, the roles here are expansive, allowing you to engage in diverse tasks. Our purpose is driven by technology, enabling a multitude of possibilities. As an entrepreneurial company with over 120 employees from about 30 different nationalities, you will be a part of a dynamic and forward-looking scale-up with great team spirit and peer support. At Canatu, the following core values define who we are and who we want to be, guiding us in our day-to-day work:
Curiosity to discover provides us with the spark that takes us out into the world to observe and find.
Commitment to achieve is how we take those discoveries from ideas to something concrete.
Collaboration for impact is required to develop what we create into impactful and meaningful products.
Passion for progress keeps us working for new ways to do things for better tomorrows.
Does this resonate? If yes, please apply already today and join us to leave your mark and do the work with an impact.
For further information please contact CTO Ilkka Varjos at +358 400372785 on Friday 9th August between 14-15 or on Monday 12th August between 14-15. Please send your CV and cover letter together with the salary request by August 15th, 2024.
The Department of Biological and Environmental Science is currently seeking to recruit staff to the position of Doctoral Researcher in Microbial Epigenetics, starting on beginning of September 2024 or as agreed, for a maximum fixed term of four years.
The genetics, epigenetics, and evolution group lead by Ilkka Kronholm studies the properties of mutations and spontaneous epigenetic changes, parental effects, and genetic architecture of complex traits. Our research questions are focused on understanding how different intrinsic and extrinsic factors affect evolutionary adaptation. As model systems we use bacteria, fission yeast, and the filamentous fungus Neurospora crassa.
The researcher will join a Research Council of Finland funded project that studies the role of adenosine methylation in adaptation. Studies in evolutionary epigenetics have largely focused on cytosine methylation in eukaryotes. However, in bacteria adenosine methylation is an important epigenetic mechanism that is known to play a role for example, in bacterial phase variation. We have observed that adenosine methylation changes happen when bacterial populations adapt to a new environment, see for example: Bruneaux et al. 2021. Roles of adenine methylation and genetic mutations in adaptation to different temperatures in Serratia marcescens. Epigenetics 17: 861-881 https://doi.org/10.1080/15592294.2021.1966215 and Bruneaux et al. 2022. The effect of a temperature-sensitive prophage on the evolution of virulence in an opportunistic bacterial pathogen. Molecular Ecology 31: 5402-18 https://doi.org/10.1111/mec.16638.
In this project we will study adenosine methylation changes in more detail and estimate genome wide the rates of spontaneous adenosine methylation changes using mutation accumulation experiments and Nanopore / PacBio sequencing. Our group has previously done mutation accumulation experiments in fungi see: Villalba de la Peña et al. 2023. Chromatin structure influences rate and spectrum of spontaneous mutations in Neurospora crassa. GenomeResearch 33: 1-13 https://doi.org/10.1101/gr.276992.122.
In this project we will also characterise different adenosine methyltransferases present in bacterial genomes, and investigate whether adenosine methylation plays any role in antibiotic resistance and its evolution. For general background on adenosine methylation in bacteria see: Sánchez-Romero & Casadesús 2020. The bacterial epigenome. Nature Reviews Microbiology 18: 7-20 https://doi.org/10.1038/s41579-019-0286-2.
The doctoral researcher is expected to contribute to the current project, plan and perform research, write manuscripts and finally a PhD thesis. While the major outlines of the project are fixed, it is possible to tailor parts of the project according to the interests of the candidate, within the overall framework of the project. Participating in limited amount of teaching can also be arranged.
Apply between 25 June 2024 and 9 August 2024 11:45 (Europe/Helsinki)
Who we are looking for
You are the person we are looking for if you have a master’s degree in microbiology, evolutionary biology, genetics, or a related discipline with a strong interest in microbial or evolutionary genetics. While previous experience with microbes is not required, it can be an advantage. Experience in analysis of sequencing (NGS) data can also be an advantage, as well as good computational skills and solid understanding of statistics, and in particular the R environment. Good written and oral communication skills in English are required.
The duties, qualification requirements and language skills of a Doctoral Researcher are stipulated by the University of Jyväskylä Regulations and language skills guidelines. The MSc degree required for the position must have been completed before starting the position. Doctoral Researcher needs to be also enrolled in the doctoral programme which can be applied from the Faculty of Mathematics and Science after selection for the position. A trial period of six months will be used in the beginning of the employment.
Benefits
At the University of Jyväskylä, you are a recognized member of our community with an ample opportunity to be drawn into international research. You get to participate in our international and multidisciplinary community, where everybody’s welfare is essential. You will work in an inspiring and lively campus area and an environment that supports a healthy and active lifestyle.
Finland has a high standard of living with healthcare, free schooling (also in English), affordable childcare, and good family benefits. The city of Jyväskylä is located in central Finland amidst Finnish lakes and has excellent opportunities for different nature, outdoor, and sports activities. It is a major educational center, whose large student population is responsible for a vibrant cultural scene. To find useful information about the University of Jyväskylä, the City of Jyväskylä, and living in Finland, see the University’s International Staff Guide.
The initial annual salary will be approximately 29,000 EUR (gross income, including a holiday bonus). With progress of the thesis work, the salary will be revised in accordance with the Collective Agreement of Finnish Universities.
Please attach the following documents to the online application form:
Curriculum vitae, composed according to good scientific practice and considering the template for researcher´s curriculum vitae by The Finnish Advisory Board on Research Integrity and including contact information of two people willing to provide a reference.
Cover letter explaining your motivation and research interests.
Relevant certificates / diplomas.
Please submit your application at the latest by 9th of August 2024 11:45 pm (GMT +2) using the online application form.
We value equality and diversity in our work community and encourage qualified applicants to apply for these positions.
Department of Biological and Environmental Science
The research in the Department of Biological and Environmental Science focuses on three core areas: evolutionary biology, natural resources and environment, and biological nanoscience. The Department building, Ambiotica, is an integral part of the University of Jyväskylä’s Ylistönrinne Mathematics and Science Research Complex, which includes buildings of chemistry, physics and nanoscience. Ambiotica houses high quality laboratories for bioscience and experimental facilities for a wide range of biological and chemical analyses as well as highly motivated laboratory personnel.
The University of Jyväskylä is a human-centered environment of 2,500 experts and 14,500 students. Our goal is to create wisdom and wellbeing for all. JYU’s naturally beautiful campus is located in the heart of the city of Jyväskylä. JYU is the third largest employer in Central Finland.
The Department of Biological and Environmental Science is currently seeking to recruit staff to the position of Postdoctoral Researcher in Microbial Epigenetics, starting on 1st of September 2024 or as agreed, for a maximum fixed term of three years.
The genetics, epigenetics, and evolution group lead by Ilkka Kronholm studies the properties of mutations and spontaneous epigenetic changes, parental effects, and genetic architecture of complex traits. Our research questions are focused on understanding how different intrinsic and extrinsic factors affect evolutionary adaptation. As model systems we use bacteria, fission yeast, and the filamentous fungus Neurospora crassa.
The researcher will join a Research Council of Finland funded project that studies the role of adenosine methylation in adaptation. Studies in evolutionary epigenetics have largely focused on cytosine methylation in eukaryotes. However, in bacteria adenosine methylation is an important epigenetic mechanism that is known to play a role for example, in bacterial phase variation. We have observed that adenosine methylation changes happen when bacterial populations adapt to a new environment, see for example: Bruneaux et al. 2021. Roles of adenine methylation and genetic mutations in adaptation to different temperatures in Serratia marcescens. Epigenetics 17: 861-881 https://doi.org/10.1080/15592294.2021.1966215 and Bruneaux et al. 2022. The effect of a temperature-sensitive prophage on the evolution of virulence in an opportunistic bacterial pathogen. Molecular Ecology 31: 5402-18 https://doi.org/10.1111/mec.16638.
In this project we will study adenosine methylation changes in more detail and estimate genome wide the rates of spontaneous adenosine methylation changes using mutation accumulation experiments and Nanopore / PacBio sequencing. Our group has previously done mutation accumulation experiments in fungi see: Villalba de la Peña et al. 2023. Chromatin structure influences rate and spectrum of spontaneous mutations in Neurospora crassa. GenomeResearch 33: 1-13 https://doi.org/10.1101/gr.276992.122.
In this project we will also characterise different adenosine methyltransferases present in bacterial genomes, and investigate whether adenosine methylation plays any role in antibiotic resistance and its evolution. For general background on adenosine methylation in bacteria see: Sánchez-Romero & Casadesús 2020. The bacterial epigenome. Nature Reviews Microbiology 18: 7-20 https://doi.org/10.1038/s41579-019-0286-2.
While the postdoctoral researcher is expected to contribute to the current project, and jointly supervise students, there is also the possibility to develop your own interests within the framework of the project or to participate in teaching if the researcher so wishes.
Apply between 25 June 2024 and 16 August 2024 11:45 (Europe/Helsinki)
Who we are looking for
You are the person we are looking for if you have a doctoral (PhD) degree in microbiology, genetics, evolutionary biology, or a related discipline with strong interest in epigenetics or microbial genetics. Previous experience with microbial work is required for this position. Experience in analysis of different types of sequencing (NGS) data, and solid understanding of statistics, and in particular the R environment, is considered an advantage. Good written and oral communication skills in English are required.
The duties, qualification requirements and language skills of a Postdoctoral Researcher are stipulated by the University of Jyväskylä Regulations and language skills guidelines. A good command of English is required, and proficiency to teach in English will be considered beneficial. The PhD degree required for the position must have been completed before starting the position. The employment starts with a trial period of six months.
Benefits
At the University of Jyväskylä, you are a recognized member of our community with an ample opportunity to be drawn into international research. You get to participate in our international and multidisciplinary community, where everybody’s welfare is essential. You will work in an inspiring and lively campus area and an environment that supports a healthy and active lifestyle.
Finland has a high standard of living with healthcare, free schooling (also in English), affordable childcare, and good family benefits. The city of Jyväskylä is located in central Finland amidst Finnish lakes and has excellent opportunities for different nature, outdoor, and sports activities. It is a major educational center, whose large student population is responsible for a vibrant cultural scene. To find useful information about the University of Jyväskylä, the City of Jyväskylä, and living in Finland, see the University’s International Staff Guide.
The initial annual salary will be approximately 44,000 – 51,000 EUR, gross income, including holiday bonus), depending on the qualifications and experience of the candidate.
How to apply?
Please attach the following documents to the online application form:
Curriculum vitae, composed according to good scientific practice and considering the template for researcher´s curriculum vitae by The Finnish Advisory Board on Research Integrity and including contact information of two people willing to provide a reference
Cover letter explaining your motivation and research interests
A numbered list of publications
Relevant certificates / diplomas
*Research plan should not be included. Due to a technical issue in the web form, please submit your motivation/cover letter here again.
Please submit your application at the latest by 16th of August 2024 11:45 pm (GMT +2) using the online application form.
We value equality and diversity in our work community and encourage qualified applicants, regardless of background, to apply for this position.
Department of Biological and Environmental Science
The research in the Department of Biological and Environmental Science focuses on three core areas: evolutionary biology, natural resources and environment, and biological nanoscience. The Department building, Ambiotica, is an integral part of the University of Jyväskylä’s Ylistönrinne Mathematics and Science Research Complex, which includes buildings of chemistry, physics and nanoscience. Ambiotica houses high quality laboratories for bioscience and experimental facilities for a wide range of biological and chemical analyses as well as highly motivated laboratory personnel.
The University of Jyväskylä is a human-centered environment of 2,500 experts and 14,500 students. Our goal is to create wisdom and wellbeing for all. JYU’s naturally beautiful campus is located in the heart of the city of Jyväskylä. JYU is the third largest employer in Central Finland.