Molecular Modeller, Orion Corporation – Orion Corporation, Espoo
17.12.2022https://www.linkedin.com/jobs/view/3385695768
About the job
Orion is seeking a Molecular Modeller (an experienced computer-aided drug design scientist) to further develop our capabilities and push the boundaries of theoretical drug discovery research carried out in Research and Development organisation’s Computational Medicine Design (CMD) unit.
Description Of Position
The Molecular Modeller will work in the drug discovery projects linking and interfacing with biology and chemistry with both physics-based and data-driven perspectives. You will be in key position to drive the molecule discovery process from target validation to development candidate. For this, it is critical to constantly refine the best suitable strategy and toolbox for each project according to the evolving data landscape and define how to increase the target understanding and how to navigate the path of multiparameter optimization in modality design. The Molecular Modeller will collaborate closely with a broad range of scientists including other molecular Modellers in the CMD unit, medicinal chemists, biophysicists, pharmacologists and biologists.
You will be based in Espoo or Turku, Finland.
Description Of Unit
Orion is a globally operating Finnish company listed on the Helsinki Stock Exchange. Orion develops, manufactures and markets human and veterinary pharmaceuticals, active pharmaceutical ingredients and diagnostic tests for global markets. Orion’s pharmaceutical innovations are created within its R&D organization, including e.g., non-clinical research, clinical development, formulation development and medical affairs. The organization employs top professionals in the field of drug molecule discovery and development.
Medicine Design contributes to the drug discovery process of Orion R&D from target validation all the way to the candidate nomination. We are responsible for translating new drug targets to therapeutical modalities together with other line functions. Our scientists in biology, chemistry and computer-aided medicine design are key players in the multiple research programs driven by Orion’s therapy areas of Oncology and Pain. We also support our colleagues around R&D with our core competences.
We offer
We offer you great, highly professional & experienced colleagues and the opportunity to show your talent and challenge yourself with interesting tasks in a modern multidisciplinary environment. Computational methods play a key role in Orion drug discovery, so this is an opportunity to contribute to helping patients in need. Generous health and welfare benefits are available, as well as support for international relocation. Read more about R&D’s pipeline from here. Orion’s R&D Pipeline | Orion
Requirements
To be the successful Molecular Modeller in our R&D, you should have the following educational and professional work experiences:
- Ph.D. from a suitable field, e.g., computational chemistry, bioorganic chemistry, biophysics, structural biology, computer science or biochemistry
- Concrete post-doctoral or industrial experience (3+ years)
- Broad experience in computational drug design, mastery of most ligand-based and structure-based approaches and their applications for medicine design
- Solid understanding of fields relevant in the discovery process (e.g., medicinal chemistry, pharmacology, biochemistry, cell biology, structural biology, biophysics)
In addition, you are expected to bolster the research unit with in depth experience in at least one of the following aspects:
- Application of large-scale modern data science, machine learning, cheminformatics and generative molecular design for drug discovery
- Large-scale molecular dynamics simulations (e.g., free energy methods) for protein-ligand complexes
- Solid track record of progressing modalities from hit identification through lead optimization to clinical candidate
Experience with commercial molecular modelling software platforms, data pipelining tools (e.g., Knime) and programming/scripting/data analysis/data visualization (e.g., Python) is desirable.
We expect from all scientists the ability to work both independently and in multidisciplinary teams consisting of in-house scientists and external collaborators. A demonstrated record of research productivity and excellent oral and written communication skills in English are expected.
Additional Information
Is this the position you have been waiting for? Please send your cover letter and CV by 1st January 2023 and let us know what inspires you! Please note that the application period is extended due to holiday season and interviews will take place in January 2023.
For additional information on the position, please contact Heikki Käsnänen, Head of Computational Medicine Design, +358 50 966 5279, during the following times: December 12th and 13th: 10 AM to 11 AM (EET).
Orion supports and assists international relocation.
Approved medical examination which also includes drug testing is required prior to the employment. We will also carry out a security clearance prior to the employment for the selected person. Orion Corporation operates in more than 30 countries, where we Orionees, 3300 in total, work in all kinds of positions. Among us there are Research Scientists, Laboratory Technicians, Engineers and IT Specialists as well as people working in Production, just to mention some examples. We offer diverse and responsible jobs to our personnel in a truly multi-disciplinary work environment. We encourage people to develop their competences and offer opportunities to affect the job description and creating their own career path at Orion. We are searching for top talents who are ready to share our passion for the work that we do.