Ajankohtaista

Scientific Associate (in vitro/in vivo Immunology) – Novartis, Basel, CH

12.9.2018

Scientific Associate (in vitro/in vivo Immunology) – Novartis, Basel, CH

Job Description

Purpose
The Autoimmunity, Transplantation and Inflammation (ATI) disease area at Novartis Institutes for BioMedical Research (NIBR) is looking for a qualified scientific associate with expertise in rodent disease models and ex vivo/in vitro cell biology to join our Integrated Pharmacology team. Reporting to the Lab Head, you will work in a science-driven environment with both exploratory and operational functions and have the opportunity to contribute to the investigation and understanding of novel pathways in immunology.
Your tasks will include

• Actively contribute to projects aiming at discovering new ways to modulate the immune system for the treatment of autoimmune diseases
• Perform mechanistic and disease studies in rodents
• Implement new in vitro and in vivo lab techniques according to literature, and explore new approaches
• Culture and characterization of primary rodent cells
• Establish and use molecular and in vitro cellular methods (e.g. assessment of different activation parameters of leukocytes) to investigate the function of primary human and mouse leukocytes
• Combinatorial application of a variety of readouts, like multicolor flow cytometry, western blots, ELISA and the assessment of leukocyte differentiation for the characterization of novel immunomodulating substances and pathways
• Induction of antigen-specific tolerance in rodent models.

Use of cellular and biochemical methods to determine activation of complement pathways in primary cells and organs (blood, urine, tissue) derived from rodents or humans

• Use of human and rodent material for drug development and target validation
  • Interact in a cross-functional and cross-divisional project team active in drug development
  • Present results at project team meetings and engage in scientific discussions with the team members

  Minimum Requirements
  

  • MSc, BSc, Diploma or strong apprenticeship in Immunology, Cellular biology, Biochemistry or another relevant scientific discipline
  • Fluency in English (oral and written). German is advantageous
  • Experience with different rodent disease models
  • Experience with experimental autoimmune encephalitis would be a strong bonus
  • Experience in rodent necropsy, tissue sampling
  • Solid knowledge of a variety of in vitro cell biology methods (flow cytometry, RT-PCR, western blot, stimulation of immune cells, complement assays)
  • Documented experience in isolating and handling primary mouse leukocytes
  • Proven practical experience in a relevant research environment; immunology background and knowledge of the complement system and/or antigen-specific tolerance is preferred
  • Theoretical knowledge of immunology and immunological methods
  • Eager to learn and combine new techniques and concepts
  • Demonstrated ability to perform exploratory activities independently and within a highly matrix team environment
  • Scientific curiosity, initiative, commitment, flexibility and good organization skills
  • Good balance between analytical thinking and a practical/pragmatic approach

  Division
  NIBR
  Business Unit
  AUTO/TRANS/INFL – NIBR
  Country
  Switzerland
  Work Location
  Basel

  Company/Legal Entity

  Novartis Pharma AG
  Functional Area
  Research & Development
  Job Type
  Full Time
  Employment Type
  Regular