A postdoctoral fellow OR graduate student position in the field of RNA Polymerase II Gene Regulation is open in Barboric laboratory, Faculty of Medicine, University of Helsinki
28.8.2017A postdoctoral fellow OR graduate student position in the field of RNA Polymerase II Gene Regulation is open in Barboric laboratory, Faculty of Medicine, University of Helsinki. The deadline for this application is October 1, 2017 or until the position is filled.
The Barboric Lab is committed to elucidating fundamental mechanisms that control the elongation phase of transcription by RNA polymerase II (Pol II) in normal and disease states. We are particularly interested in essential cyclin-dependent kinases which trigger Pol II release from promoter-proximal pausing and facilitate productive Pol II elongation along genes. We employ biochemistry, genetics and genome wide approaches to understand how Pol II pause release is controlled by the positive transcription elongation factor (P-TEFb) and its inhibitory 7SK snRNP complex. Moreover, we are examining how another critical transcription elongation kinase, the Cdk12/CycK complex, impacts target gene expression, and how frequent CDK12 mutations in ovarian carcinoma perturb gene expression to enable genesis of this deadly disease. Finally, we are aiming to define novel mechanisms that promote integration of Pol II transcription with maturation of precursor RNA transcripts. Salary of the successful candidate will be provided by the 4-year grant entitled ‘Significance of transcription elongation kinases in DNA damage response’, which was funded recently by The Academy of Finland.
Requirements
I am looking for a creative and independent thinker with a strong passion for science and the ability to excel in a competitive field of gene transcription. The competitive candidate should hold MSc or PhD degree in molecular biology, biochemistry, bioinformatics or related fields. Wide expertise in biochemistry and molecular biology is a pre-requisite for the position. In addition, expertise in the analysis of next generation sequencing data is appreciated. Excellent publication record as well as good command in spoken and written English is required. Please send your application including a cover letter, CV, summary of your research interests, and 2-3 letters of reference to [matjaz.barboric@helsinki.fi]matjaz.barboric@helsinki.fi.
I am looking for a creative and independent thinker with a strong passion for science and the ability to excel in a competitive field of gene transcription. The competitive candidate should hold MSc or PhD degree in molecular biology, biochemistry, bioinformatics or related fields. Wide expertise in biochemistry and molecular biology is a pre-requisite for the position. In addition, expertise in the analysis of next generation sequencing data is appreciated. Excellent publication record as well as good command in spoken and written English is required. Please send your application including a cover letter, CV, summary of your research interests, and 2-3 letters of reference to [matjaz.barboric@helsinki.fi]matjaz.barboric@helsinki.fi.
Employment conditions
Selected candidate will be offered employment contract in accordance to the University of Helsinki salary scale system with the initial 4-month trial period.
Selected candidate will be offered employment contract in accordance to the University of Helsinki salary scale system with the initial 4-month trial period.
Faculty of Medicine offers a unique and stimulating research environment surrounded by state-of-the-art resources and facilities of the leading and largest biomedical research campus in Finland.http://www.biomed.helsinki.fi/english/
The University of Helsinki is a research oriented university which offers stimulating and international environment and ranks amongst top 15 best universities in Europe, www.helsinki.fi/en
The University of Helsinki rents apartments with quite reasonable rents to the international post-docs. Employees of the University of Helsinki are covered by excellent health insurance that is free of charge, www.helsinki.fi/intstaff/
For further information, please contact:
Matjaz Barboric, Ph.D.
Principal Investigator
Faculty of Medicine, University of Helsinki
Faculty of Medicine, University of Helsinki
Biomedicum Helsinki 1, Room B131b
Haartmaninkatu 8, 00290 Helsinki, Finland
Email: [matjaz.barboric@helsinki.fi]matjaz.barboric@helsinki.fi