Ajankohtaista

Etusivu › Ajankohtaista › AjankohtaistaAjankohtaista › Avoimet työpaikat
Liity jäseneksi Tee osoitteenmuutos Ilmoita tapahtuma

POSTDOCTORAL RESEARCHER POSITION in COMPUTATIONAL GENOMICS and EVOLUTION

28.4.2017 | Ajankohtaista

The Department of Biosciences, Department of Computer Science and Institute of Biotechnology, at the University of Helsinki, invite applications for a three year

POSTDOCTORAL RESEARCHER POSITION in COMPUTATIONAL GENOMICS and EVOLUTION

Evolution connects all living organisms and is the common thread across all of biology. Organisms evolve to better survive in their environments and to adapt to new challenges. This leads to complex dynamical scenarios, which are presently understood only in a limited way. Understanding evolution is one of the most intriguing scientific topics due to its ability to unify often seemingly disjoint fields of biology. Furthermore, quantitative understanding of evolution is a prerequisite to successfully combat pathogens, pests and loss of biodiversity. For instance, identifying genetic variants which contribute to the emergence of drug resistance, a question with importance for the treatment of pathogens, and of cancer, is a challenge of understanding the evolution of these populations. Big Data provide new opportunities to study in detail how populations evolve. However, data alone, without theory and scalable algorithms to extract information from it, is not sufficient to make progress. The Mustonen Group develops computational algorithms and theory to better understand evolution. The work is cross-disciplinary and we have a record of successful research collaborations working together with clinicians and experimentalists.

We are now seeking a highly motivated researcher with strong quantitative skills to work on one of the following themes:

• Theory and methods for evolutionary prediction and control (1,2)
• Algorithms for biomedical applications of Big Data (3,4)
• Characterisation of the emergence of drug resistance (5)

The ideal candidate will have extensive experience in genomic data analyses, machine learning and evolution. However, as our research is cross-disciplinary it is possible to contribute coming from several different fields. Thus, we welcome applications from exceptional candidates, with a quantitative background, from other fields. However, it is essential to have a genuine interest in Biology and Evolution. It is also important for the candidate to have strong programming skills and experience in working with large data sets.

Knowledge, skills and experience required: E = Essential, D = Desirable
• Genuine interest in Biology and Evolution (E)
• PhD in a relevant subject area (Physics, Mathematics, Computer Science, Engineering, Statistics, Computational Biology, Bioinformatics, Genetics, Molecular Biology) (E)
• Ability to develop novel quantitative models and read mathematical literature (E)
• Experience in formulating statistical models and applying them to real data (D)
• Full working proficiency in a scripting language (e.g. Python, R, Perl) and UNIX/Linux (E), and in a compiled language (e.g. C, C++) and cluster based computing (D)
• Ability to work independently, organise workload, and communicate ideas and results (E)
• Strong publishing record (E)
• Knowledge of genomics and molecular biology (D)
• Proven record in problem solving, data analysis and generation of novel ideas (D)

Please submit your application as a single pdf file which includes:

• CV and list of publications
• a copy of your transcript records (i.e. printout of the courses completed during MSc/PhD)
• contact details of two references (e.g. MSc/PhD thesis supervisors)
• a cover letter with a description of your research interests

The postdoctoral researcher will be employed on a full-time, fixed term, three-year contract with a four-month probation. The salary will be based on level 5 of the demands level chart for teaching and research personnel in the salary system of Finnish universities. In addition, the appointee will be paid a salary component based on personal performance with the overall salary amounting to approximately 3 000-3 500 €/month (gross). All standard pension benefits and occupational health care are provided for university employees.

To apply, please submit your application using the University of Helsinki electronic recruitment system by clicking on Apply for job. Internal applicants (i.e. current employees of the University of Helsinki) must submit their applications through the SAP HR portal. Apply at latest on 26th of May 2017, start date for the position is negotiable.

For more information, please contact Prof. Ville Mustonen (v.mustonen@helsinki.fi).

1. Lässig M, Mustonen V, Walczak AM (2017) Predicting Evolution. Nature Eco Evol 1:0077.
2. Fischer A, Vázquez-García I, Mustonen V (2015) The value of monitoring to control evolving populations. Proceedings of the National Academy of Sciences 112(4):1007–1012.
3. McKerrell T, et al. (2016) Development and validation of a comprehensive genomic diagnostic tool for myeloid malignancies. Blood. doi:10.1182/blood-2015-11-683334.
4. Fischer A, Vázquez-García I, Illingworth CJR, Mustonen V (2014) High-definition reconstruction of clonal composition in cancer. Cell Reports 7(5):1740–1752.
5. Vázquez-García I, Salinas F, Li J, Fischer A, Barré B, Hallin J, Bergström A, Alonso-Perez E, Warringer J, Mustonen V, Liti G Background-dependent effects of selection on subclonal heterogeneity. http://dx.doi.org/10.1101/039859

Apply at latest 28.05.2017

AP­PLY LINK

https://rekry.helsinki.fi/sap/bc/erecruiting/posting_apply?param=cG9zdF9pbnN0X2d…

DUE DATE

Sunday, May 28, 2017

DOCTORAL STUDENT POSITION in COMPUTATIONAL GENOMICS and EVOLUTION

28.4.2017 | Ajankohtaista

The Department of Biosciences, Department of Computer Science and Institute of Biotechnology, at the University of Helsinki, invite applications for a four year

DOCTORAL STUDENT POSITION in COMPUTATIONAL GENOMICS and EVOLUTION

Evolution connects all living organisms and is the common thread across all of biology. Organisms evolve to better survive in their environments and to adapt to new challenges. This leads to complex dynamical scenarios, which are presently understood only in a limited way. Understanding evolution is one of the most intriguing scientific topics due to its ability to unify often seemingly disjoint fields of biology. Furthermore, quantitative understanding of evolution is a prerequisite to successfully combat pathogens, pests and loss of biodiversity. For instance, identifying genetic variants which contribute to the emergence of drug resistance, a question with importance for the treatment of pathogens, and of cancer, is a challenge of understanding the evolution of these populations. Big Data provide new opportunities to study in detail how populations evolve. However, data alone, without theory and scalable algorithms to extract information from it, is not sufficient to make progress. The Mustonen Group develops computational algorithms and theory to better understand evolution. The work is cross-disciplinary and we have a record of successful research collaborations working together with clinicians and experimentalists.

We are now seeking a highly motivated student with strong quantitative skills to pursue a PhD on one of the following themes:

• Theory and methods for evolutionary prediction and control (1,2)
• Algorithms for biomedical applications of Big Data (3,4)
• Characterisation of the emergence of drug resistance (5)

The ideal candidate will have a quantitative background, genuine interest in Biology and Evolution, programming skills and some experience in working with large data sets.

Requirements for the Ph.D. student are:

• M.Sc. in a relevant subject area (Physics, Mathematics, Computer Science, Engineering, Statistics, Computational Biology, Bioinformatics, Genetics, Molecular Biology)
• Proven academic ability
• Strong motivation, drive and curiosity

Please submit your application as a single pdf file which includes:

• CV with possible publications listed
• a copy of your transcript records (i.e. printout of the courses completed during MSc)
• contact details of two references (e.g. MSc thesis supervisors)
• a cover letter with a description of your research interests

The salary for four years (3-month probation period) is based on levels 2-4 of the job requirement scheme for teaching and research personnel in the salary system of Finnish universities (2100-3300€/month (gross)). The appointee shall be paid a salary component based on personal work performance.

To apply, please submit your application using the University of Helsinki electronic recruitment system by clicking on Apply for job. Internal applicants (i.e. current employees of the University of Helsinki) must submit their applications through the SAP HR portal. Apply at latest on 28th of May 2017, the start date is negotiable.

For more information, please contact Prof. Ville Mustonen (v.mustonen@helsinki.fi).

1. Lässig M, Mustonen V, Walczak AM (2017) Predicting Evolution. Nature Eco Evol 1:0077.
2. Fischer A, Vázquez-García I, Mustonen V (2015) The value of monitoring to control evolving populations. Proceedings of the National Academy of Sciences 112(4):1007–1012.
3. McKerrell T, et al. (2016) Development and validation of a comprehensive genomic diagnostic tool for myeloid malignancies. Blood. doi:10.1182/blood-2015-11-683334.
4. Fischer A, Vázquez-García I, Illingworth CJR, Mustonen V (2014) High-definition reconstruction of clonal composition in cancer. Cell Reports 7(5):1740–1752.
5. Vázquez-García I, Salinas F, Li J, Fischer A, Barré B, Hallin J, Bergström A, Alonso-Perez E, Warringer J, Mustonen V, Liti G Background-dependent effects of selection on subclonal heterogeneity. http://dx.doi.org/10.1101/039859

Apply at latest 28.05.2017

AP­PLY LINK

https://rekry.helsinki.fi/sap/bc/erecruiting/posting_apply?param=cG9zdF9pbnN0X2d…

DUE DATE

Sunday, May 28, 2017

PhD positions in Cancer Research at the German Cancer Research Center (DKFZ) in Heidelberg

26.4.2017 | Ajankohtaista
PHD POSITIONS IN CANCER RESEARCH
 
Are you looking for excellent research opportunities for your PhD studies at the forefront of cancer research? The German Cancer Research Center (DKFZ) in Heidelberg invites  international students holding a Master’s degree in (molecular) biology, (bio-)chemistry, (bio-)physics, computational biology, computer science, epidemiology/
public health studies and related subjects to apply for the International PhD Program.
 
PhD students are supported by a Thesis Advisory Committee, participate in scientific and professional skills courses, attend international conferences and receive career development support. The language of the PhD program is English. Full funding is provided for the duration of the PhD, either by the DKFZ, third party sources or in collaboration with the DAAD within  their Graduate School Scholarship Program.
 
Research at the DKFZ is organized into the following programs with a lot of interaction and interdisciplinary PhD projects available across different topics:
• Cell Biology and Tumor Biology
• Functional and Structural Genomics
• Cancer Risk Factors and Prevention
• Tumor Immunology
• Imaging and Radiooncology
• Infection, Inflammation and Cancer
• Translational Cancer Research
 
For more information and to apply online visit
www.dkfz.de/phd
 
Application deadline is 31st May 2017.

13 PhD Fellowship positions available in the Marie Skłodowska-Curie Actions Innovative Training Network ”PATHSENSE” (H2020-MSCA-ETN-721456) Ref. No. NUIG 072-17

26.4.2017 | Ajankohtaista
Training Network to Understand and Exploit Mechanisms of Sensory Perception in Bacteria
Located in Ireland, Germany, Netherlands, Spain, Sweden, Switzerland and UK
 
Project background and goal: The PATHSENSE (Pathogen Sensing) ETN investigates the molecular mechanisms of sensory perception in bacterial pathogens. Rapid and sensitive systems to sense and respond to environmental changes are a cornerstone of a bacterium’s survival apparatus, and understanding these sensory systems is central to predicting their behaviour. The success of bacterial pathogens is underpinned by their ability to sense their environment in order to protect themselves and then to deploy their virulence mechanisms at the appropriate time. A deep knowledge of how their first line of defence (sensory perception) functions is a vital step in developing strategies to subvert their survival apparatus, and ultimately to preventing human, animal and plant infections.
 
The overall objective of this project is to focus on understanding a highly sophisticated but poorly understood sensory organelle called the “stressosome”. The relationship between molecular structures and biological function is central to understanding any living system; however the research methodologies required to unravel these relationships are often complex and fast-changing. The team participating in the PATHSENSE Network will recruit and train 13 early stage researchers (ESRs) in state-of-the art methodologies, including structural biology, proteomics & protein biochemistry, molecular biology, bacterial genetics, food microbiology, mathematical modelling, cell biology, microscopy and comparative genomics. This inter-sectoral Network comprises 8 leading Universities, 1 public research institution, 4 companies (from spin-off to large multi-national) and 1 governmental agency. A major objective of this Network will be to exploit the fundamental research to develop novel antimicrobial treatments that have applications in the food and public health sectors.
 
To apply and for further details on these opportunities see:
 
Closing date for receipt of applications is 5pm (GMT) on Friday 12th May 2017.

Postdoctoral position in structural biology (2 – 3 years) at the University of Oulu

26.4.2017 | Ajankohtaista
The University of Oulu in Northern Finland, with approximately 16,000 students and 3,000 employees, is an international, multidisciplinary research university with a rich pool of creative and intellectual talent. The strengths of the University include broad, multidisciplinary research interests, a modern research and study environment, and wide cooperation with international research and educational institutes (http://www.oulu.fi/university/). 
An open postdoctoral position is available in the field of structural biology in the research group of Prof. Petri Kursula, focusing on membrane protein structural biology and the formation of proteolipid membrane multilayers in the nervous system myelin sheath. The position is located at the Faculty of Biochemistry and Molecular Medicine (FBMM) (http://www.oulu.fi/fbmm/), whose mission is to perform internationally significant research and to deliver high-level undergraduate and postgraduate education in the fields of biochemistry and molecular medicine. Research at the Faculty is carried out in 14 research groups. The Faculty has ~200 employees, and approximately half of them are from abroad. Together with Biocenter Oulu (http://www.oulu.fi/biocenter/), the Faculty has put a great effort towards building a cutting-edge research infrastructure that includes state-of-the-art instrumentation for imaging, gene-modified mice, X-ray crystallography, and quantitative biochemistry. The Faculty has extensive collaborative national and international networks including Biocenter Finland and the ESFRI projects Instruct, EuroBioimaging, and Infrafrontier. We also partner in EU-Biostruct-X and Marie Curie Renaltract ITN and organize EMBO workshops and international symposia. The research group has well-established international collaborative networks and frequent access to synchrotron radiation. 
 
Applications, together with all relevant enclosures, must be submitted using the electronic application form by 15.5.2017. Applications sent by email will not be considered.

UniProt Curation Team Leader, EMBL-EBI Hinxton near Cambridge, UK

11.4.2017 | Ajankohtaista
We are seeking a highly experienced biocurator to become a faculty level Team Leader for the Protein Function Content Team at the European Bioinformatics Institute (EMBL-EBI), located on the Wellcome Genome Campus, near Cambridge, in the UK. The Protein Function Content Team Leader manages a team of expert biologists in manual curation of proteins as part of the international UniProt (http://www.uniprot.org ) and GO (http://www.geneontology.org) consortia, as well as other related data resources.
 
More information and application at http://s.embl.org/EBI00896
 
Deadline for applications is 17.4.2017.

PhD Studentship – Drug / Gene Delivery, National University of Ireland Galway (NUI Galway), Galway, Ireland

10.4.2017 | Ajankohtaista
www.finbionet.fi/PhD_Fellowship_NUI_Galway_Teagasc.pdf
 
Description:
Applications are invited from suitably qualified candidates for a full-time PhD position at the National University of Ireland, Galway. The position is funded from Teagasc (ReValueProtein
Research Project) and the Department of Agriculture, Food and the Marine, under the National Development Plan 2007–2013 of the Irish Government. The position is available immediately. Stipend (€16,000 per year) and EU fees are covered from the grant. The project aims to develop and assess in vitro and in vivo drug / gene loaded biomaterials.
 
Recruiting Institute:
REMODEL: http://remodel.ie
SFI CÚRAM: http://www.curamdevices.ie
NUI Galway: http://www.nuigalway.ie
 
Qualifications:
The candidate should have a 1st class or a 2:1 honours first degree and a Master’s in biomaterials, biomedical engineering, tissue engineering, medicine, cell biology, biology, drug discovery or in a related area. The ideal candidate should have experience in as many of the following techniques: scaffold fabrication, functionalisation and characterisation; cell (permanently differentiated and stem cells) biology; molecular biology; protein / gene analysis; histology; and immunohistochemistry. Candidates should have excellent communication and organisational skills; be highly motivated and passionate about developing new products; and have strong written, oral and interpersonal skills. The candidate should be able to work independent and as a part of team.
 
Duties:
Scaffold fabrication, functionalisation, and characterisation; Cell acquisition from human and animal tissues; In vitro models; In vitro and in vivo work; Conference / Meeting attendance; Report / paper writing; Attendance to various training courses; Other duties relevant to the post.
 
Start Date:
The post is available from May 2017 onwards.
 
To Apply:
Applicants should submit a cover letter outlining their suitability to the post, a detailed CV and the contact details of three referees. The application pack should be emailed to Dr Dimitrios Zeugolis at dimitrios.zeugolis@nuigalway.ie. Closing date for receipt of applications is 17.00 on Friday 28th of April 2017.
 
Equal Opportunities Statement:
The National University of Ireland Galway is an equal opportunities employer.

PhD Studentship – Cell-based therapies Regenerative, Modular & Developmental Engineering Laboratory (REMODEL) Science Foundation Ireland (SFI) Centre for Research in Medical Devices (CÚRAM) National University of Ireland Galway (NUI Galway), Galway, Ireland

10.4.2017 | Ajankohtaista

www.finbionet.fi/PhD_Fellowship%20_NUI_Galway.pdf

Description:
Applications are invited from suitably qualified candidates for a full-time PhD position at the National University of Ireland, Galway. The position is funded from Science Foundation Ireland
(Tissue Engineered Nanoassemblies of Advanced Biomimicry of Living Equivalents Projects). The position is available immediately. Stipend (€16,000 per year) and EU fees are covered from the grant. The project aims to develop cell therapies based on induced pluripotent stem cells.
 
Recruiting Institute:
REMODEL: http://remodel.ie
SFI CÚRAM: http://www.curamdevices.ie
NUI Galway: http://www.nuigalway.ie
 
Qualifications:
The candidate should have a 1st class or a 2:1 honours first degree and a Master’s in cell biology, tissue engineering, biomedical engineering, medicine, biology, or in a related area. The ideal candidate should have experience in as many of the following techniques: in vitro culture systems (e.g. 3D culture; bioreactors); cell (permanently differentiated, stem cells, engineered cells) biology; molecular biology; protein / gene analysis; histology; and immunohistochemistry. Candidates should have excellent communication and organisational skills; be highly motivated and passionate about developing new products; and have strong written, oral and interpersonal skills. The candidate should be able to work independent and as a part of team.
 
Duties:
Cell acquisition from human and animal tissues; In vitro / ex vivo cell / organ culture; development of advanced therapy medicinal products; In vivo work; Conference / Meeting attendance; Report / paper writing; Attendance to various training courses; Other duties relevant to the post.
 
Start Date:
The post is available from May 2017 onwards.
 
To Apply:
Applicants should submit a cover letter outlining their suitability to the post, a detailed CV and the contact details of three referees. The application pack should be emailed to Dr Dimitrios Zeugolis at dimitrios.zeugolis@nuigalway.ie. Closing date for receipt of applications is 17.00 on Friday 28th of April 2017.
 
Equal Opportunities Statement:
The National University of Ireland Galway is an equal opportunities employer.

The Department of Anesthesiology and Washington University Pain Center seeks a Postdoctoral Research

16.3.2017 | Ajankohtaista
POSTDOCTORAL RESEARCH FELLOW
 
The Department of Anesthesiology and Washington University Pain Center seeks a Postdoctoral Research Fellow for a trained behavioral pharmacologist and biochemist/molecular biologist to study mechanisms underlying opioid dependence and to examine the interaction between pain and opioid misuse (see Fakira et al., 2014 Biological Psychiatry; Portugal et al., 2014 Journal of Neuroscience;  Hipolito et al., 2015 Journal of Neuroscience; Fakira et al., 2016 Neuropsychopharmacology). The laboratory integrates the study of the molecular and cellular changes induced by drugs of abuse using a combination of state-of-art behavioral, optogenetics, chemogenetics approaches in combination with electrophysiological analyses. For more details see lab web page (http://elysium.wustl.edu/moron-concepcion_lab/)
 
Candidates must have a PhD in neuroscience, biochemistry, pharmacology or biomedical sciences. Experience with behavioral pharmacology expertise, opto/chemogenetics, molecular biology, biochemical techniques is required. The successful candidate should be able to work independently and be willing to collaborate with the groups of Dr Rob Gereau and Michael Bruchas at the Department of Anesthesiology.
 
Interested candidates should also forward their CV and names of 3 references to:
 
Jose A. Morón Concepción, PhD
Associate Professor
Depts of Anesthesiology & Neuroscience
Washington University School of Medicine
E-mail: jmoron-concepcion@wustl.edu

A postdoctoral position is available immediately at the Virginia Commonwealth University (VCU) School of Medicine

16.3.2017 | Ajankohtaista
Postdoctoral Position:  Mechanisms of synaptodendritic injury in opiate abuse and HIV comorbidity
A postdoctoral position is available immediately at the Virginia Commonwealth University (VCU) School of Medicine to study fundamental mechanisms underlying glial dysfunction and synaptodendritic injury in the striatum and hippocampus following drug and HIV exposure.
The candidate will utilize and integrate cellular and molecular approaches to elucidate mechanisms by which opiate abuse exacerbates glial dysfunction and synaptodendritic injury in neuro-acquired immunodeficiency syndrome (neuroAIDS). A Ph.D. and/or M.D. or equivalent is required, and experience in molecular and/or virological approaches is preferred. The candidate will join a team that utilizes multi-disciplinary cell signaling, pharmacological, immunological, neurophysiological (optogenetic), virological, and behavioral strategies to explore opiate-HIV interactions in murine (in vitro and in vivo) and human (in vitro) models. The candidate will be provided with significant training in those disciplines with which they are less familiar, as well as significant mentoring to facilitate their transition to an independent research career.
Interested individuals are encouraged to forward a curriculum vitae, a list of three references, and a statement of research interests and career goals to Dr. Kurt F. Hauser, Professor, Department of Pharmacology & Toxicology, Institute for Drug & Alcohol Studies, VCU School of Medicine, Kontos Medical Science Building, 1217 E. Marshall St., Richmond, VA 23298 (email:kurt.hauser@vcuhealth.org) or Dr. Pamela E. Knapp, Professor, Department of Anatomy and Neurobiology, Institute for Drug and Alcohol Studies, VCU School of Medicine, Kontos Medical Science Building, 1217 East Marshall Street, Richmond, VA 23298 (e-mail: pamela.knapp@vcuhealth.org).