Doctoral Researcher, Biochemistry, Structural Biology and Drug Discovery – University of Oulu
27.3.2022https://www.linkedin.com/jobs/view/2982782742
About the job
We, at the University of Oulu, work as part of the international science community to produce new scientific information and science-based solutions. We are committed to educate future pioneers to build a more sustainable, intelligent and humane world. Creating new, taking responsibility and succeeding together are values that build a strong foundation for all our actions. We offer a working environment where individuals can cultivate their skills, do meaningful work, and develop professionally. Our university’s several specialized research and service units enable extensive and diverse development and career opportunities for experts in various fields.
For More Information
The University of Oulu Graduate School (UniOGS) provides the framework and conditions for high-quality, research-driven doctoral education at the University of Oulu, and field-specific doctoral training is provided by its multidisciplinary doctoral programs.
We have now an opening for a fixed-term, full-time doctoral researcher position in a research project headed by Professor Lari Lehtiö in the Protein and Structural Biology research unit. The doctoral studies are expected to be completed in four years.
Protein and structural biology is one of the three research focus areas of the Faculty of Biochemistry and Molecular Medicine. The Faculty provides a dynamic research surrounding and cutting-edge research infrastructure services to academics and other users in Finland and abroad. It has about 190 employees (including doctoral researchers) of which about half are from outside of Finland.
The host research team also belongs to Biocenter Oulu (
Our team focuses on structure, function and selective inhibition of proteins involved in signaling through ADP-ribosylation – a post translational modification affecting protein stability, function, and interactions in multiple cellular pathways. We develop assays suitable for high-throughput screening of inhibitors and use structural information for more rational design to develop specific inhibitors that can be used as chemical probes to study the functions of the proteins and, in some cases, to validate them as drug targets. Protein X-ray crystallography is our main tool used to understand structure-activity relationships of compounds.
More information
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Supervisor will be professor Lehtiö and the project is focused on the discovery of small molecule inhibitors of human and virus macrodomains to be used as research tools and as potential future drug leads. Additionally, the researcher is expected to contribute to other synergistic projects of the team.
Requirements
To successfully occupy the position, the candidate must possess a Master’s degree or an equivalent degree (e.g. licentiate) preferably in biochemistry. Degree must have been completed with good grades by 30.4.2022 or strong evidence for graduation during summer 2022 must be demonstrated.
The position is intended for an Early-Stage Researcher (ESR) who is defined as a researcher in the first four years (full-time equivalent) of candidate`s research activity, including the period of research training. Applicants will be either starting their doctoral training or will have completed no more than two full years of training (adjusted for possible previous part-time status) at the time the position is filled. The selected candidate will carry out their doctoral studies in the HBS-DP of the UniOGS and must meet the minimal requirements to receive doctoral study rights as defined in
Salary
The salary of the selected Doctoral Researcher will be initially set on level 2, and later on levels 2 – 4 of the national salary scale for teaching and research staff of Finnish universities. In addition, a supplementary remuneration is given for personal achievement and performance (max. 50 %). In practice, the salary is roughly 2,300 – 3,000 € per month for an early-stage researcher, depending on the appointee’s qualifications and progress of the doctoral thesis.
The position is filled for a maximum of four-year period. The employment begins on May 1 st 2022 or as soon as possible thereafter. A six-month trial period is applied in the positions.
Application
Applications must be submitted using the electronic application form by April 24 th , 2022 (23:59 Finnish local time, EET), with the following attachments as three separate pdf files:
Complete CV containing contact information of at least two referees (Max. size limit of the attachment: 5 Mbytes) according to the guidelines of Finnish National Board on Integrity:
Motivation letter describing prior knowledge and research interests and career plans (1 – 2 pages; max. size limit of the attachment: 2 Mbytes)Certificates/Diplomas: Scanned electronic copies of diplomas and transcripts of the records of relevant previous degrees. If the original documents are not in English, Finnish, or Swedish, each document must be accompanied by an official certified translation into English or Finnish. (Max. size limit of the attachment: 2 Mbytes)
Other Relevant Information
The eligible applicants fitting best in the research profile expected for the position may be invited to an on-site or remote interview. All applicants will be notified when the selection process is completed.
For Further Information
Professor Lari Lehtiö, e-mail: lari.lehtio (at) oulu.fi
About Oulu, Finland
Finland is one of the most livable countries in the world, with a high quality of life, safety, excellent education system, and competitive economy. The Oulu region is home to over 200 000 people making it the largest urban centre in the Nordics and one of the fastest growing regions in northern Finland. Oulu is a combination of beautiful, northern nature, vivid cultural life, and modern technology. Oulu is also known for its highly educated people and friendly, easy-going atmosphere. Living in Oulu is easy – everything is only max. 20 minutes away! Find out more about Oulu: