Post-doc position in Functional Genomics26.9.2016
We recently discovered a gene that explains 40% of the variation in age (and size) at maturity in Atlantic salmon (Barson et al. 2015). The gene, VGLL3, is a transcription co-factor that negatively regulates adipocyte differentiation in mice, and has been linked to pubertal timing in humans, but nothing is known about its role in regulating puberty in salmon. This post-doc will play a major role in designing and performing the experiments needed to fill this knowledge gap.
The post-doc will be responsible for conducting and co-supervising research within the project using various genomic, cellular and physiological approaches, e.g. expression profile characterization (both RNA and protein levels), ChIPseq, as well as functional validation (e.g. using CRISPR/Cas9) of candidate genes for life history traits such as age at maturity (Barson et al. 2015). Spending longer periods at collaborator labs in Norway may also be required. Experimental design and interpretation of results will be coordinated with a second postdoc project with an evolutionary and ecological focus that is being advertised simultaneously.
Suitable applicants will have a strong background in functional genomics and molecular biology in any species as demonstrated by publications in relevant fields. Experience with methodologies such as qPCR and CRISPR technologies, in-situ hybridization, immunohistochemistry and other relevant methodologies is an advantage, as is knowledge of bioinformatics, a demonstrated interest in evolutionary genomics and/or experience with fish husbandry.
Informal inquiries should be directed to Prof. Craig Primmer (firstname.lastname@example.org). Formal applications should include a CV (with names and contact details of at least two referees), a publication list and a max. 2 page letter of motivation and can be uploaded at http://www.utu.fi/en/university/university-as-an-employer/open-vacancies/Pages/home.aspx. The deadline for applications is October 9, with the preferred starting date being January 2017. The position is available until the end of 2019 with a further 2 year extension possible. The starting salary is »3155 – 3500 EUR per month, depending on the previous relevant research experience of the candidate.
Barson et al. (2015) Sex-dependent dominance at a single locus maintains variation in age at maturity in salmon. Nature 528:405–408.
Aykanat T et al. 2015. Low but significant genetic differentiation underlies biologically meaningful phenotypic divergence in a large Atlantic salmon population. Molecular Ecology 24, 5158–5174
Johnston et al. 2014. Genome-wide SNP analysis reveals a genetic basis for sea-age variation in a wild population of Atlantic salmon (Salmo salar). Molecular Ecology 23:3452–3468.