Postdoc for the development of CRISPR genome editing services in the Brakebusch Group at BRIC, University of Copenhagen




CRISPR genome editing has dramatically facilitated the generation of genetically modified mice in recent years. In a rapidly developing field, new procedures with further improvements are published nearly every day and great research activity is ongoing to increase in particular the efficiency of introducing defined changes into the genome. In close collaboration with the Brakebusch group, the Transgenic Mouse Core Facility at the University of Copenhagen was one of the first places in Europe to generate genetically modified mice by CRISPR technology and since then established it as a routine transgenic technology. To stay at the front of mouse genome editing and to establish a molecular biology service for CRISPR genome editing tools at the Transgenic Mouse Core Facility, the Brakebusch group is now announcing a 2 year postdoc position, which, if successful, could be continued.

Our research/The Group
The Brakebusch group is investigating the function of Rho GTPases and Rho GTPase effectors in vivo using genetically modified mice with CRISPR genome editing as a central technology. We have strong experience in molecular and cellular biology and the analysis of mouse phenotypes, while all transgenic technologies such as ES cell manipulation, embryo injections, and embryo transfers, are placed at the Transgenic Mouse Core Facility, headed by Cord Brakebusch.

The research project
The postdoc will test and develop molecular biology methods to improve the generation of CRISPR genome edited mice. Successful methods will then be translated into novel molecular biology services at the Transgenic Mouse Core Facility. Aim is to establish within 2 years a state-of-the-art service that will then be continued together with the technology development activities.

Start: Preferably May 2017 or after agreement
Duration: 2 years

We expect you to be a highly motivated and highly ambitious scientist with the following qualifications:

  • A PhD in Life Sciences and preferably postdoctoral research experience
  • Excellent expertise in molecular biology
  • Excellent experience in CRISPR genome editing including design and preparation of constructs for homologous recombination
  • High interest in developing the best CRISPR genome editing service possible
  • Excellent English skills written and spoken

For further information regarding the position, please contact Cord Brakebusch (cord.brakebusch@bric.ku.dk)

Place of employment
The employment is at BRIC, University of Copenhagen. BRIC is located in the Biocenter, close to the centre of Copenhagen. We offer creative and stimulating working conditions in a dynamic and international research environment. Our research facilities include modern laboratories and a number of core facilities shared between the 23 research groups at BRIC and the neighboring Finsen Laboratory. We have weekly journal clubs, data clubs, seminars with invited speakers and a young researchers club ASAP and our own PhD programme, MoMeD and our own Postdoc Career Programme. BRIC actively participates in the European alliance, EU-life consisting of 13 excellent life science research institutions http://eu-life.eu/

Please read more about the Brakebusch research group and BRIC on http://www.bric.ku.dk/ and about the Transgenic Mouse Core Facility on http://www.transgenicmice.ku.dk

Terms of salary and employment
Salary, pension and terms of employment will be in accordance with the agreement between the Ministry of Finance and The Academics Central organization. Currently, the monthly salary starts at 32.351 DKK/ca. 4.250 Euro plus pension. Depending on qualifications, a higher salary may be negotiated.

Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.

The position is covered by the “Memorandum on Job Structure for Academic Staff at the Universities” of June 28, 2013.

Your application must be submitted electronically by clicking ‘Apply now’ below or via BRIC’s website on http://www.bric.ku.dk/jobs/. The application must include the following documents/attachments – all in PDF format:


  1. Motivated letter of application (max. one page).
  2. CV incl. education, work/research experience, language skills and other skills relevant for the position.
  3. A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do.
  4. List of publications.

Letters of recommendation
Furthermore, the applicant should provide two letters of recommendation. To be taken into consideration, the letter must be signed by the supporting person on paper with institutional letter head and in PDF-format. The letters should be received before deadline on jobs@bric.ku.dk with subject “name candidate-Brakebusch-postdoc-March2017”; preferably by the supporting person. Please make sure that an easy match between the recommendation letter and the individual applicant is possible.

Application deadline: 23-03-2017

We reserve the right not to consider material received after the deadline, and not to consider applications or letters of recommendation that do not live up to the above-mentioned requirements.

The further process
Shortlist: After expiry of the application deadline, the superior with power to appoint selects a number of applicants for assessment on the advice of the Appointments Committee. All applicants are immediately notified whether their application has been passed for assessment. Applicants who were not passed for assessment should not expect further with regard to their application unless the shortlist is revised.

Assessment: The selected applications will be assessed according to the Ministry Order on the Appointment of Academic Staff at Universities 2012 and the University of Copenhagen’s guidelines 2013. The Assessment Committee makes a non-prioritized assessment of the academic qualifications and experience with respect to the above mentioned area of research, techniques, skills and other requirements listed in the advertisement.

You can read about the recruitment process at http://employment.ku.dk/faculty/

BRIC and University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of personal background.