Scientific Associate (in vitro/in vivo Immunology) – Novartis, Basel, CH


Scientific Associate (in vitro/in vivo Immunology) – Novartis, Basel, CH

Job Description

The Autoimmunity, Transplantation and Inflammation (ATI) disease area at Novartis Institutes for BioMedical Research (NIBR) is looking for a qualified scientific associate with expertise in rodent disease models and ex vivo/in vitro cell biology to join our Integrated Pharmacology team. Reporting to the Lab Head, you will work in a science-driven environment with both exploratory and operational functions and have the opportunity to contribute to the investigation and understanding of novel pathways in immunology.
Your tasks will include

  • Actively contribute to projects aiming at discovering new ways to modulate the immune system for the treatment of autoimmune diseases
  • Perform mechanistic and disease studies in rodents
  • Implement new in vitro and in vivo lab techniques according to literature, and explore new approaches
  • Culture and characterization of primary rodent cells
  • Establish and use molecular and in vitro cellular methods (e.g. assessment of different activation parameters of leukocytes) to investigate the function of primary human and mouse leukocytes
  • Combinatorial application of a variety of readouts, like multicolor flow cytometry, western blots, ELISA and the assessment of leukocyte differentiation for the characterization of novel immunomodulating substances and pathways
  • Induction of antigen-specific tolerance in rodent models.

Use of cellular and biochemical methods to determine activation of complement pathways in primary cells and organs (blood, urine, tissue) derived from rodents or humans

  • Use of human and rodent material for drug development and target validation
    • Interact in a cross-functional and cross-divisional project team active in drug development
    • Present results at project team meetings and engage in scientific discussions with the team members

    Minimum Requirements

    • MSc, BSc, Diploma or strong apprenticeship in Immunology, Cellular biology, Biochemistry or another relevant scientific discipline
    • Fluency in English (oral and written). German is advantageous
    • Experience with different rodent disease models
    • Experience with experimental autoimmune encephalitis would be a strong bonus
    • Experience in rodent necropsy, tissue sampling
    • Solid knowledge of a variety of in vitro cell biology methods (flow cytometry, RT-PCR, western blot, stimulation of immune cells, complement assays)
    • Documented experience in isolating and handling primary mouse leukocytes
    • Proven practical experience in a relevant research environment; immunology background and knowledge of the complement system and/or antigen-specific tolerance is preferred
    • Theoretical knowledge of immunology and immunological methods
    • Eager to learn and combine new techniques and concepts
    • Demonstrated ability to perform exploratory activities independently and within a highly matrix team environment
    • Scientific curiosity, initiative, commitment, flexibility and good organization skills
    • Good balance between analytical thinking and a practical/pragmatic approach

    Business Unit
    Work Location

    Company/Legal Entity

    Novartis Pharma AG
    Functional Area
    Research & Development
    Job Type
    Full Time
    Employment Type