Ajankohtaista

Ph.D. student, fungal molecular biology

Form of employment: Full time, Fixed term

Locations: Espoo, Finland

Job area: Research and Development

Application period: Monday, October 29, 2018 – Sunday, November 25, 2018

With us you will be responsible for

completing your Ph.D. thesis on the study of cellular metabolism and production of extracellular proteins. You will be working as a part of an Academy of Finland funded research project “Interplay between metabolism and protein secretion in saprotrophic fungi”. The main emphasis of your work will be identifying important regulatory connections between cellular metabolism, secretory pathway and production of extracellular enzymes in the saprotrophic model organism Trichoderma reesei. As a member of the Protein Production Team, you will be part of wider efforts to better understand and develop fungal protein production hosts, such as Trichoderma reesei.

We expect you to have

completed your master’s degree so that you can start your Ph.D. thesis work in January 2019. You should have good laboratory skills and experience in molecular biology techniques and bioinformatics. Experience working with yeast or filamentous fungi would be beneficial, but not mandatory. Strong spoken and written English skills are required.

As a person you are

motivated to complete a Ph.D. thesis and willing to take initiative in getting the project accomplished. You should have strong communication skills as well as be able to work both independently and as a member of a team. You should have curiosity towards various scientific and technological challenges. You should be willing to travel and work abroad as part of short collaboration projects.

We offer

an opportunity to complete a Ph.D. thesis working on an interesting and cutting edge research project, expert guidance, and an opportunity to work with an experienced research team to better understand fungal protein production hosts used for production of industrial enzymes.

For further information

Chris Landowski
Research Team Leader
christopher.landowski@vtt.fi

Turku, Finland

The Turku Site, with 550 employees, represents one of PerkinElmer’s major manufacturing and product development sites for newborn- and maternal fetal health screening. As the global market leader in newborn screening, our solutions have tested over 560 million babies worldwide for life-threatening diseases.

Role description:

• You will be a key member and expert of technologies related to bioaffinity assays in product development teams
• You will apply the scientific method to solve problems and to design new products that are safe and effective in their intended uses
• You will have an essential role in planning and reporting of feasibility, stability and verification studies, and process characterization and validation studies
• You will work in the lab yourself as well as direct the work of lab technicians
• You will be interacting a lot within your team and with other teams from various functions present at Turku site and other PerkinElmer sites

Role requirements:

• Degree (MSc or PhD) in Chemistry/Biology/Biochemistry or equivalent education
• Proven expertise on bioaffinity assays (immunoassays, ligand binding assays) and especially: DELFIA, ELISA, CLIA, Upconverting label technologies
• Fluent reporting and communication skills in English and Finnish
• Proactive, resourceful, independent and a good team player in the cross-functional and international development team
• Strong background and practical working knowledge from GLP/GMP level Pharma, Biotech or Life Science industry

What we offer:

• Inspiring leadership and exceptional employees
• Dynamic and innovative culture
• Focus on career development
• Collaborative and diverse environment

This position is permanent. Please apply by November 18th, 2018.

PerkinElmer Turku Site is a drug free site and a medical examination for new employees includes a drug test.

A career at Merck is an ongoing journey of discovery: our 53,000 people are shaping how the world lives, works and plays through next generation advancements in healthcare, life science and performance materials. For 350 years and across the world we have passionately pursued our curiosity to find novel and vibrant ways of enhancing the lives of others.

Your role: We are looking for a skilled future colleague to manage our therapeutic area medical activities in oncology. You will be responsible to develop and contribute to local medical/study strategy and overall tactics in close collaboration with Head of Medical Affairs in Finland. You will provide medical expertise and education on oncology products and related launches and will ensure optimal positioning of existing products by participating and making active contributions. You will be responsible to establish and maintain the scientific image and reputation of the company within this key binding role between science and business. You will establish and actively manage scientific relations with key customers, for example oncologists, pathologists, surgeons and nurses. This role focuses on internal and external activities, and will be 50% field-based.

Who you are

• You have a University degree preferably in life sciences (MSc, PhD, Pharm.D. M.D.), advanced degree preferred
• Scientific/clinical knowledge in oncology is considered as an asset
• The position requires professional experience of at least 2 years. Prior industry experience and knowledge of medical affairs, regulatory, safety or clinical operations is considered an asset
• You are a positive team player, self-driven and have excellent collaboration and communication skills
• You have an ability to manage multiple tasks and tight deadlines with a results-driven attitude
• You are fluent in Finnish and English

What we offer: At Merck, there are always opportunities to break new ground. We empower you to fulfil your ambitions, and our diverse businesses offer various career moves to seek new horizons. We trust you with responsibility early on and support you to draw your own career map that is responsive to your aspirations and priorities in life. Join us and bring your curiosity to life!

Curious? Apply and find more information at come2merck.com

Orion Corporation operates in more than 20 countries, where we Orionees, 3300 in total, work in all kinds of positions. Among us there are Research Scientists, Laboratory Technicians, Engineers and IT Specialists as well as people working in Production, just to mention some examples. We offer diverse and responsible jobs to our personnel in a truly multi-disciplinary work environment. We encourage people to develop their competences and offer opportunities to affect the job description and creating their own career path at Orion. We are searching for top talents who are ready to share our passion for the work that we do.

Description of position:

We are looking for an in vivo PK scientist to join Orion R&D Discovery PK/PD team in Turku. The position is temporary maternity leave substitution.

In this role you are responsible to participate in Orion R&D projects in different nonclinical phases as a pharmacokinetic expert. Your tasks include planning, executing and overseeing in vivo PK-studies as well as reporting and data-analysis. You work closely with bioanalytical and ADME scientists as well as with biomarker and PD scientists. In addition, you interpret and communicate results effectively to multidisciplinary project teams.

You will be reporting to Head of Discovery PK/PD.

Description of unit:

Discovery PK/PD unit is part of Orion Translational Pharmacology and Safety Sciences platform with facilities in Turku. The organization is responsible for the preclinical PK/PD assessment of new drug candidates during various stages of the drug discovery and development process. The function designs and executes pharmacokinetic and pharmacodynamic studies both in our own facilities and in collaboration with contract research organizations. We support research and development projects at all Orion’s therapy areas.

We Offer:

We offer exciting opportunities to create and have an impact on the future therapies for patients.

We also offer you attractive career development opportunities for using your own strengths for development, highly interesting R&D pipeline and enthusiastic working environment. Appreciation of personnel and constant development are part of our core values.  The culture of Orion R&D is informal and we enjoy working together.

We are passionate about the patient welfare and are The Voice of Science and the Patient – do you share the same values?

The position is located in Turku, Finland.

We expect you to have

• • M.Sc./Ph.D. degree in relevant field of science
  • In depth knowledge in pharmacokinetics
  • Good understanding of nonclinical research
  • A keen understanding of experimental design, underlying scientific principles and the ability to rigorously analyze and interpret results
  • Excellent networking, presentation and communication skills in English
  • Ability to coordinate, prioritize and get things done
  • We also value ability to provide novel solutions and ability to synthesize scientific problems into strategy
  • Enthusiastic, innovative and science-oriented mindset

You are team and goal orientated and cope well with setbacks. You are self-guided and proactive person but in this position will always have team of professionals to work with.
Additional information on the position:

Eija Aho, Head of Discovery PK/PD, R&D, tel. +358 50 966 7675, firstname.surname@orionpharma.com

Please, send your application by 11th of November through our web page www.orion.fi.

For nearly 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

STUDY DIRECTOR IN VIVO

We are looking for scientist with proven track of experience in in vivo neuroscience to join Charles River Discovery Research Service site located in Kuopio, Finland.The position require an expertise in in vivo pharmacological studies in CNS area that enable to discuss and conclude in vivo data from efficacy studies in injury triggered animal models CNS diseases for example ischemia models, TBI, SCI, etc.

In this position you are responsible to lead Client projects in CNS drug discovery field. The Study Director will ensure the scientific excellence of study design, execution, data analysis and reporting. The Study Director will lead execution of the projects working closely with the team. The responsibilities of this position include communication with the Clients in all phases of the projects. The position require an expertise in in vivo animal models of CNS diseases, as well as capabilities to set up and develop new techniques and models in R&D projects. The Study Director will provide scientific input and assist in preparation of marketing materials.

Qualifications

• • Higher education degree in biological science (MSc, MD), preferably PhD degree
  • At least 2-3 years of experience with CNS in vivo work, including proven track of independent project execution and project management
  • Knowledge and practical experience in conducting studies in animal models of ischemia and/or traumatic brain injury and/or spinal cord injury is required, conducting efficacy studies experience will be an asset
  • Understanding and practical experience with in vivo pharmacology studies in CNS area including both genetically modified animal models and surgically/chemically induced models and related behavioral assays
  • Understanding of scientific studies experimental design, underlining scientific principles, and ability to analyze data and interpret results
  • Ability to quickly adapt to challenging research environment and to effectively utilize knowledge and experience in various scientific projects
  • Fluent English oral and written, scientific writing ability, excellent communication skills, interpersonal, and teamwork abilities
  • Good problemsolving skills, ability to coordinate and prioritize
  • Pharmaceutical industry, Preclinical Contract Research Organization or academic post-doctoral experience will be an asset
  • Proven track of people management, ability to mentor and train staff will be as asset

About Discovery

Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 320 patents and 74 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.

About Charles River

Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.

With over 11,000 employees within 70 facilities in 18 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2016, revenue increased by 23.3% to $1.68 billion from $1.36 billion in 2015.

At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~70% of the drugs approved by the FDA in 2016.

For more information, please visit www.criver.com.