3.9.2023 | Avoimet työpaikat
https://www.linkedin.com/jobs/view/3695898027
About the job
The Fagerholm group at the Molecular and Integrative Bioscience (MIBS) Research programme, Faculty of Biological and Environmental Sciences, University of Helsinki is seeking to recruit a
POSTDOCTORAL RESEARCHER
The position is available from 1st October 2023 for a minimum of 2 years with a possibility of extension. The postdoc will participate in an Academy of Finland -funded project which investigates integrin-regulated dendritic cell programming, immunodeficiency disease and inflammation.
The Fagerholm group consists of Immunologists and Biochemists working together to understand the molecular mechanisms which regulate immune cell trafficking and function in vivo . We are especially interested in the role of integrins in immune system regulation and in immune-system related diseases such as immunodeficiency and cancer. We use a wide range of techniques such as mouse models, tumor models, in vivo immune cell migration and other functional assays, flow cytometry, cell biology, imaging and next generation sequencing techniques to understand the molecular mechanisms involved in the regulation of immune cell function. We are part of the vibrant MIBS community, which investigates a variety of research questions related to molecular and mechanistic principles of life, ranging from virology and structural biology, to immunology, metabolism, stem cell biology and neurosciences.
This project will investigate the role of dendritic cell (DC)-tissue interactions and integrin-mediated mechanotransduction in regulating DC-mediated immune responses and inflammation in vivo . It will utilize sophisticated integrin mouse models, combined with multiomics approaches, to investigate the role of beta2-integrin-mediated mechanotransduction in regulating classical DC programming on the single cell level. This position requires a deep interest and/or experience in immunology, single cell sequencing approaches and multiomics, and/or bioinformatics. Especially experience in single cell sequencing approaches and analysis is seen as an advantage, and candidates with such skills are encouraged to apply.
Qualifications
Applicants should possess a PhD degree in a relevant field (or be about to graduate) and an excellent academic record. They should have a strong understanding of basic principles of in vivo immunology and/or single cell sequencing/bioinformatics, and have the ability to work productively both independently and as part of a team. The duties include a small amount of teaching and supervising students.
The salary of the successful candidate will be based on level 5 of the demands level chart for teaching and research personnel in the salary system of Finnish universities. In addition, the appointee will be paid a salary component based on personal performance. The starting salary will be ca. 3300–3700 euros/month, depending on the appointee’s qualifications and experience. A six-month trial period will be applied.
Finland is one of the most livable countries, with a high quality of life, safety and excellent education system. The successful candidate will receive the benefits provided by the University of Helsinki to university employees, including occupational health care services, and obtain access to high-quality public affordable childcare services and schools.
How To Apply
Application should include the following documents as a single pdf file:
- a motivation letter
- a CV and
- the names and contact details of 2 referees.
Deadline for application is 7 September (at 23.59 EEST) but review of applications will begin immediately and continue until the position is filled.
External applicants, please submit your application using the University of Helsinki Recruitment System via the Apply Now button.
Applicants who have a helsinki.fi username and a valid employment contract, a grant researcher’s contract or a visiting researcher’s contract at the University of Helsinki are requested to leave their application by using the Employee Login button.
The University of Helsinki welcomes applicants from a variety of genders, linguistic and cultural backgrounds.
More information:
- Informal enquiries about the position should be sent to susanna.fagerholm@helsinki.fi
For an outline of the group’s research: https://www.helsinki.fi/en/researchgroups/integrins-in-immunity
- Recruitment system: HR Specialist Mirkka Juntunen, mirkka.juntunent@helsinki.fi
- Viikki Campus: https://www.helsinki.fi/en/about-us/campuses/viikki-campus
- Support for international staff: https://www.helsinki.fi/en/about-us/careers/welcome and https://ihhelsinki.fi (International House Helsinki)
Recent publications from the lab include :
- McDonald C, Morrison V, McGloin D and Fagerholm SC. 2022. Examining the effect of kindlin-3 binding site mutation on LFA-1-ICAM-1 bonds by force measuring optical tweezers. Front Immunol. 12: 792813
- Guenther C, Faisal I, Fusciello M, Sokolova M, Ilander M, Harjunpää H, Tallberg R, Vartiainen M, Gonzalez-Granado J-M, Alon R, Cerullo V, Fagerholm SC. 2021. β2-integrin adhesion regulate dendritic cell epigenetic and transcriptional landscapes to restrict dendritic cell maturation and tumour rejection . Cancer Immunol Res. 9:1354–69
- Guenther C, Faisal I, Uotila LM, Asens ML, Harjunpää H, Savinko T, Öhman T, Yao S, Moser M, Morris SW, Tojkander S, Fagerholm SC. 2019. A β2-Integrin/MRTF-A/SRF Pathway Regulates Dendritic Cell Gene Expression, Adhesion, and Traction Force Generation. Front Immunol. 10:1138.
- Savinko T, Guenther C, Uotila LM, Llort Asens M, Yao S, Tojkander S, Fagerholm SC. 2018. Filamin A Is Required for Optimal T Cell Integrin-Mediated Force Transmission, Flow Adhesion, and T Cell Trafficking. J Immunol 200:3109-3116.
- Savinko T, Morrison V, Uotila L, Wolff H, Alenius H, Fagerholm SC. 2015. Functional beta2-integrins restrict skin inflammation in vivo, J Invest Dermatol.135(9):2249-57 .
6 . Morrison VL, James MJ, Grzes K, Cook P, Glass DG, Savinko T, Lek HS, Gawden-Bone C, Watts C, Millington OR, MacDonald AS, Fagerholm SC. 2014. Loss of beta2-integrin-mediated cytoskeletal linkage reprograms dendritic cells to a mature migratory phenotype . Nat Commun. 5: 5359.
3.9.2023 | Avoimet työpaikat
https://www.linkedin.com/jobs/view/3701056412
About the job
The University of Eastern Finland is inviting applications for a Doctoral Researcher position in Biomaterials or Nanomedicine at the Department of Technical Physics on the Kuopio campus. The position will be filled for a fixed term from 1 Oct. 2023 (or starting date as agreed). Please find more information below and submit your application no later than 7 September 2023.
Role and salary
We are seeking for a highly motivated and talented Doctoral Researcher to work full-time on the project that focuses on the development of novel nanomaterials to deliver therapeutic agents such as mRNA as antiviral vaccines. The work is primarily done in the Pharmaceutical Physics Group (see: https://sites.uef.fi/ppg/), University of Eastern Finland. The project includes national and international collaboration.
The position will be filled for a fixed term from 1 October 2023 to 31 August 2027 (or starting date as agreed) due to it pertaining to a specific project task and own doctoral degree. A probationary period is applied to all new members of the staff. Candidates who are currently completing or have recently completed a Master’s degree or equivalent are invited to apply.
The salary of the position is determined in accordance with the salary system of the Finnish universities. The salary comprises two components: a job requirement component and a personal performance component. In this position, the job requirement level is based on levels 2–4 on the job requirement chart for teaching and research staff. The personal performance salary element is 6–50% of the job-related salary element. At the beginning of the employment, the salary of the Doctoral Researcher will be approximately €2,534–2,662 /month.
Our Requirements And Expectations
- A person to be appointed as a Doctoral Researcher shall be qualified to pursue postgraduate studies.
- Potential candidates should have a good command of the English language (work language: English).
- Master’s degree or equivalent in materials chemistry, biomaterials, biomedicine, nanomedicine, nanotechnology, antiviral vaccines, or a related field is required. The candidates who don’t yet hold the degree before the call deadline are also eligible to apply.
The following will be considered an advantage:
- Practical experience in one or several of the following techniques: chemical synthesis of nanoparticles, drug delivery (e.g., peptide, protein, DNA, or RNA), and cell culture.
- The ability to work efficiently as part of an international team.
Your Benefits
You will have access to the university’s staff benefits, including:
- Extensive occupational health care
- Staff discount on lunch in our campus restaurants, as well as on a range of other services
- Affordable sports services and tax-free bike benefit
Please read more in the Work at UEF section on our website
You will have an opportunity to work in an interesting and diverse role as part of our international, creative, participatory and inclusive academic community.
Enjoy your life in Finland! Known for its cleanliness, welfare know-how, modern technology and superb education system, Finland is an exotic and safe country to work in. Please visit the Life in Finland section on our website to learn more.
How to apply?
Submit your application by using our electronic application form no later than 7 September 2023 (by 24 hours Finnish time).
Please note that you must include the following appendices in your application:
- CV (http://www.tenk.fi/en/template-researchers-curriculum-vitae, but also other styles will be accepted)
- list of publications, if applicable
- copies of your academic degree certificates/diplomas, and copies of certificates/diplomas relating to your language proficiency, if not indicated in the academic degree certificates/diplomas
- a transcript of records
- a motivation letter (max. 2 pages)
- other documents you wish to include to demonstrate your merits for the position (maximum 3 pages). Do not attach MSc/BSc thesis PDF files, provide a link to them in your CV (if applicable).
Questions?
For further information on the position, please contact Adjunct Professor Wujun Xu, email: wujun.xu@uef.fi, tel.+358 40 355 2348.
For further information on the application procedure, please contact Human Resources Coordinator Noora Hämäläinen, e-mail: noora.hamalainen@uef.fi, tel. +358 29 445 8302.
The Faculty of Science, Forestry and Technology operates on the Kuopio and Joensuu campuses of the University of Eastern Finland. The mission of the faculty is to carry out internationally recognised scientific research and to offer research-education in the fields of natural sciences, forestry and technology. The faculty invests in all of the strategic research areas of the university. The faculty’s environments for research and learning are international, modern and multidisciplinary. The faculty has approximately 2,650 Bachelor’s and Master’s degree students and some 440 postgraduate students. The number of staff amounts to 610.
The University of Eastern Finland, UEF, is one of the most multidisciplinary universities in Finland. We have a staff of 3,200 members, and our academic community comprises around 16,000 degree students. Our campuses are located in Joensuu and in Kuopio. Our research is ranked among the best in the world in several fields. We generate research-based knowledge and make it openly accessible for the benefit of all. To learn more about our university please visit our website at www.uef.fi/en. On our website, you’ll also find information about the university as a work community and as an employer (https://www.uef.fi/en/article/one-university-a-thousand-stories), as well as our employees’ career stories (https://www.uef.fi/en/career-stories).
Työsopimuksen voimassaolo: määräaikainen työsopimus | Työsuhteen luonne: kokoaikainen | Paikkojen lukumäärä: 1 | Työllisyysaste: 100% | Paikkakunta: Kuopio | Maakunta: Pohjois-Savo | Maa: Finland | Ilmoitusnumero: 3394/01.01.03/2023 | Yhteys: Wujun Xu +358294453308, | Julkaistu: 2023-08-22 | Haku päättyy: 2023-09-07
3.9.2023 | Avoimet työpaikat
https://www.linkedin.com/jobs/view/3697311676
About the job
Are you an expert in human genetics and inherited diseases? Do you have the ambition to utilize your experience in genetic interpretation whilst being among the pioneers of the molecular era of medicine? Are you passionate about helping patients? If you answered “yes,” you might be the person we are looking for!
Blueprint Genetics, a Quest Diagnostics company, is on a mission to bring world-class genetic knowledge to mainstream healthcare. We are a team of experienced professionals with diverse backgrounds, who share a passion for helping patients and families affected by inherited disorders. We work with hundreds of clinics around the globe and the quality of our interpretation has been praised by many of the world’s best medical centers.
To support our rapid growth, we are looking for a Geneticist to join our Helsinki Clinical Interpretation Team.
Job Description
In this Geneticist position, you will have the opportunity to work with an experienced and motivated geneticist team that places great value in high-class clinical interpretation. We have a diverse genetic testing portfolio, including over 220 panels across 14 medical specialties, whole exome sequencing, approximately 3,900 single genes, and targeted variant analysis.
Your daily work will entail analyzing the genetic data with our in-house developed interpretation tool and writing the test results into high-quality written statements. Interpretation of the data requires the use of several databases, genetic tools, and understanding of how the clinical history of the patient matches with the findings. In more challenging cases, you are supported by a group of senior staff with experience on various medical specialties and product categories.
Our global and multidisciplinary team of geneticists is a unique group of more than 50 PhD level scientists and Clinical Laboratory Geneticists. Our team members have an average of more than 13 years of previous scientific experience, several years in clinical diagnostics (per person), and altogether approximately 500 peer-reviewed scientific articles published. Thus, you will be supported by a group with extensive experience in the field.
What We Expect From You
We are looking for a person with a patient-first mindset, who is truly motivated to find answers for individuals affected by inherited diseases. You are able to deliver high-quality results independently, and taking responsibility comes naturally to you. At the same time, you are a team player with an eagerness to work towards a common goal. You are enthusiastic about keeping up with the most recent scientific findings and developing your expertise. You work efficiently under pressure in a fast-paced production environment and you adjust effortlessly to evolving situations.
Our Ideal Candidate Has
- PhD in Genetics or Molecular Medicine (or equivalent), or Clinical Laboratory Geneticist degree in Clinical Molecular Genetics / Laboratory Genetics and Genomics
- Excellent understanding of human genetics, inheritance models and inherited human diseases, and the ability to understand medical terminology and learn clinical aspects of the diseases
- Uncompromised attention to detail. In practice this means that an analytical, critical and systemic approach, as well as ability to follow rules, is needed to maintain coherent variant classifications throughout the team and the high quality of the reports.
- Excellent verbal and written skills in English are a necessity
Additional Valued Assets
- Knowledge of current genomic information and variant databases, in addition to experience in NGS methods
- Research or clinical experience in interpreting genetic test results utilizing NGS, Sanger sequencing and other methods
- Experience in whole exome analysis
- Verbal and written skills in Finnish
What We Offer
- The opportunity to work for a company that makes a real difference – Blueprint Genetics has a clear and motivating purpose to improve the lives of patients and families affected by inherited diseases and this commitment is something our Clinical Interpretation team takes great pride in.
- A positive, open, and international work environment with great people from different fields of expertise. We are a team of close to 300 experienced professionals, who collaborate to drive genetic knowledge forward
- Flexible working conditions, remote working opportunities, and employee benefits such as participation in performance-based bonus payment system, extensive occupational healthcare with Heltti, sports, culture & wellbeing benefit and office & team events
How To Apply
If you are interested to hear more, please submit your application and CV at the latest on September 11, 2023. Interviews will be started during the application period and the position will be filled as soon as a suitable candidate is found. We hope to hear from you soon!
This position is preferably based out of our office in Espoo, but there is also a possibility to work remotely from other parts of Finland.
If you have any further questions about the position you can turn to our Sr. Genetics Director Tiia Kangas-Kontio by email tiia.kangas-kontio@blueprintgenetics.com.
Who We Are
Blueprint Genetics is a Quest Diagnostics company. Quest Diagnostics, A Fortune 500 company, is the world’s leading provider of diagnostic information services. www.questdiagnostics.com
We are changing diagnostics by providing accessible and actionable genetic knowledge in all medical specialties. Our mission is to support healthcare professionals around the world in providing the best care for patients and families with rare inherited diseases. We do that by delivering answers using fast, affordable, and comprehensive genetic diagnostics.
3.9.2023 | Avoimet työpaikat
https://www.linkedin.com/jobs/view/3703514194
About the job
- Location: Finland
- 100% field based, frequent travel is required
- Job type: Permanent, Full time
About The Job
Our Team:
In this role you will implement the medical and scientific (non-promotional) strategy for the Immunology Respiratory therapeutic area and other key medical affairs initiatives primarily in the field in collaboration with internal and external stakeholders, in alignment with the immunology North Europe medical strategy, and according to the highest ethical and compliance standards. You will join a high performing team with a can-do attitude to create and to deliver value to HCPs and patients.
This is a local role with field-based work. Travel is expected in the country in scope and occasional travel within the Nordic and North Europe region.
Main responsibilities:
- Identify, develop and maintain collaboration with current and future Key Opinion Leaders.
- Regular external scientific/medical presentations, e.g. scientific conferences, high-level scientific or business audiences.
- Maintain and develop strong relationships with local scientific societies and central decision makers at relevant health authorities.
- Drive organization and implementation of Advisory Boards and other scientific meetings.
- Oversee and interpret new scientific data, literature, competitive trends and opportunities and adjust medical and educational activities accordingly.
- Support local market access medical alignment and new indication launch preparation.
- Be proactive and active contributor to the cross functional local brand plan, dossiers etc
- Be a strong partner to the local Commercial, Market Access, Regulatory, Pharmacovigilance and Public Affairs, and provide continuous medical advice and training.
About You
- At least Master level degree in medicine or other life science, preferably a PhD degree in medicine, or other life science.
- Pharmaceutical industry experience, experience from a similar position is a plus.
- Experience in communication with medical authorities, hospitals, physicians /specialists and KOLs as well as other healthcare sector professionals.
- Experience in interpretation and dissemination of scientific and clinical data.
- Team player and strong interpersonal skills.
- High initiative and problem solving skills.
- Ability to coordinate, manage and prioritize resources and workload in a busy professional environment
- Strategic mind-set whilst being target-oriented and results-driven, with an understanding of short- and long-term goals.
- Balanced, yet structured, and fast in decision making processes.
- Professional and mature projection, and self-confident behaviour.
- Business proficiency in English, native Finnish.
Pursue progress. Discover extraordinary.
Better is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people.
At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, or gender identity.
Watch our ALL IN video and check out our Diversity Equity and Inclusion actions at sanofi.com!
At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.
3.9.2023 | Avoimet työpaikat
https://www.linkedin.com/jobs/view/3706438073
About the job
Doctoral Programme in Biomedicine, salaried doctoral researcher positions Doctoral researchers for different scientific fields
The University of Helsinki doctoral programmes invite applications for doctoral researchers starting from 1 January 2024 for a 1–4 year period. The university’s doctoral researchers, supervised by top-class researchers, carry out their research as part of an international academic community.
Position description
The duties of a doctoral researcher are to work on their doctoral thesis and to complete the doctoral studies determined by the curriculum of each doctoral programme. The duties may also include teaching and other tasks for up to 5 % of the annual working time. The duration of the employment contract depends on the phase of the appointee´s thesis and starts with a trial period of six months.
The University of Helsinki offers:
- The chance to work in an international, multidisciplinary research community
- Excellent research infrastructure and support services
- Occupational health service and other personnel benefits
- A competitive salary
The salary for doctoral researchers at the beginning of their dissertation work is usually 2300-2650€ per month. As work on the dissertation progresses, the demands level of the salary rises. Salaries for doctoral researcher positions are based on level 2–4 of the job requirement scheme for teaching and research personnel in the salary system of Finnish universities. In addition, the doctoral researcher will be paid a salary component based on personal work performance.
The University of Helsinki Doctoral School has 33 doctoral programmes. The University awards some 500 doctoral degrees annually.
Qualifications
Applications are evaluated based on the quality of the research plan, available supervision arrangements, and the ability and motivation, as demonstrated through previous studies, academic performance, or other previously acquired knowledge and experience, to pursue the doctoral degree according to the research plan and the accompanying study plan. The research plan must fit the research profile of the doctoral programme.
A share of the positions are earmarked in particular for Multidisciplinary research on One Health including a global dimension in all fields of science.
The appointee must obtain the right to pursue a doctoral degree at the University of Helsinki during the probationary period. It is possible to start the employment relationship only after the degree (higher university degree or equivalent), which makes you eligible for doctoral studies, has been completed and obtained.
Doctoral Researchers selected for the positions are employed by the University of Helsinki and are expected to reside in Finland while employed by the University of Helsinki. Each employment is placed in a suitable Faculty, a unit within a Faculty, or an Independent Institute.
The research work or part of it may be carried out outside University of Helsinki, for example in a state research institute, company, or other organization in Finland, but the employment and academic supervision are based in the University of Helsinki. Temporary research-based visits abroad are possible.
Interested in the position?
The application deadline is 14.9.2023. Applicants will be informed of decisions in December 2023.
Acquaint yourself with the application instruction from this link: University-funded doctoral researcher positions and the doctoral programme-specific instructions .
The University of Helsinki is committed to promoting equality and preventing discrimination in all its operations. We encourage and welcome applications from people of all backgrounds.
Working for the world
Science has the power to change the world. Join one of the best research universities in the world – an international community united through bold thinking, science, research, and learning, with over 30,000 students and 8,000 employees.
We are defined by our multidisciplinary approach. This, combined with a dedication for cross-border collaboration, gives us our potential to find real solutions and build hope for a better, more sustainable future.
We are united by our values – truth, bildung, freedom, and inclusivity – as well as our passion for work that truly matters.
Join us: WORK FOR THE FUTURE – WORK FOR THE WORLD. #helsinkiunicareers
3.9.2023 | Avoimet työpaikat
https://www.linkedin.com/jobs/view/3706434996
About the job
Doctoral Programme in Drug Research, salaried doctoral researcher position Doctoral researchers for different scientific fields
The University of Helsinki doctoral programmes invite applications for doctoral researchers starting from 1 January 2024 for a 1–4 year period. The university’s doctoral researchers, supervised by top-class researchers, carry out their research as part of an international academic community.
Position description
The duties of a doctoral researcher are to work on their doctoral thesis and to complete the doctoral studies determined by the curriculum of each doctoral programme. The duties may also include teaching and other tasks for up to 5 % of the annual working time. The duration of the employment contract depends on the phase of the appointee´s thesis and starts with a trial period of six months.
The University of Helsinki offers:
- The chance to work in an international, multidisciplinary research community
- Excellent research infrastructure and support services
- Occupational health service and other personnel benefits
- A competitive salary
The salary for doctoral researchers at the beginning of their dissertation work is usually 2300-2650€ per month. As work on the dissertation progresses, the demands level of the salary rises. Salaries for doctoral researcher positions are based on level 2–4 of the job requirement scheme for teaching and research personnel in the salary system of Finnish universities. In addition, the doctoral researcher will be paid a salary component based on personal work performance.
The University of Helsinki Doctoral School has 33 doctoral programmes. The University awards some 500 doctoral degrees annually.
Qualifications
Applications are evaluated based on the quality of the research plan, available supervision arrangements, and the ability and motivation, as demonstrated through previous studies, academic performance, or other previously acquired knowledge and experience, to pursue the doctoral degree according to the research plan and the accompanying study plan. The research plan must fit the research profile of the doctoral programme.
The appointee must obtain the right to pursue a doctoral degree at the University of Helsinki during the probationary period. It is possible to start the employment relationship only after the degree (higher university degree or equivalent), which makes you eligible for doctoral studies, has been completed and obtained.
Doctoral Researchers selected for the positions are employed by the University of Helsinki and are expected to reside in Finland while employed by the University of Helsinki. Each employment is placed in a suitable Faculty, a unit within a Faculty, or an Independent Institute.
The research work or part of it may be carried out outside University of Helsinki, for example in a state research institute, company, or other organization in Finland, but the employment and academic supervision are based in the University of Helsinki. Temporary research-based visits abroad are possible.
Interested in the position?
The application deadline is 14.9.2023. Applicants will be informed of decisions in December 2023.
Acquaint yourself with the application instruction from this link: University-funded doctoral researcher positions and the doctoral programme-specific instructions .
The University of Helsinki is committed to promoting equality and preventing discrimination in all its operations. We encourage and welcome applications from people of all backgrounds.
Working for the world
Science has the power to change the world. Join one of the best research universities in the world – an international community united through bold thinking, science, research, and learning, with over 30,000 students and 8,000 employees.
We are defined by our multidisciplinary approach. This, combined with a dedication for cross-border collaboration, gives us our potential to find real solutions and build hope for a better, more sustainable future.
We are united by our values – truth, bildung, freedom, and inclusivity – as well as our passion for work that truly matters.
Join us: WORK FOR THE FUTURE – WORK FOR THE WORLD. #helsinkiunicareers
3.9.2023 | Avoimet työpaikat
https://www.linkedin.com/jobs/view/3702460183
About the job
Eliisa Kekäläinen’s research group “Inborn and acquired immunodeficiencies” at the Translational Immunology Research Program at University of Helsinki, Faculty of Medicine invites applications for the position of
POSTDOCTORAL RESEARCHER
Our research group focuses on the human thymus which produces key immune cells, the T cells. We 1) evaluate and develop methods to better measure thymopoiesis, 2) study how thymopoiesis and the thymus itself is affected by viral infections, and 3) aim to understand how and why certain autoimmune diseases, such as myasthenia gravis, develops. We use thymic tissue samples from both immunologically healthy individuals and patients with cutting edge techniques including thymic organ cultures and different multi-dimensional single-cell methods to dissect the normal and pathological processes in the thymus. We are seeking for a motivated post-doctoral researcher to work on Research Council of Finland – funded project.
Qualifications
Applicants with a doctoral degree and strong background in immunology or other relevant life science fields who are interested in working in an inter-disciplinary environment are particularly encouraged to apply. Applicant must be able to work independently and have good communication skills in English. The chosen applicant is expected to reside in Finland while employed by the University of Helsinki.
The person we are looking for has:
- effective communication and collaboration skills
- proven track record in designing and executing experimental science
- motivation and determination to learn (more) immunology
Furthermore, if you have experience with the topics below, we would love to hear about your
- supervision experience
- working with tissue samples or organoid cultures
- experience in flow cytometry, single-cell omics, CRISPR-Cas or immunohistochemistry
What We Offer
The appointment will be initially for two years starting from January 2024 (possibility to start earlier or later if needed). Trial period of six months will be applied. The monthly gross salary will be appr. 3200-3600 € per month depending on the appointee’s qualifications and experience. In addition, University of Helsinki offers comprehensive services to its employees, including occupational health care and opportunities for professional development. Applicants of any gender, linguistic and cultural background or from members of minority groups are welcomed. You can read more about working at the university on our website .
We offer you on top of these benefits an opportunity to explore and learn in a team that shares a passion for immunology. The team’s well-being is top priority in our laboratory.
How To Apply
Please submit your application as a single PDF file containing your CV, a publication list where you describe your own role in the publications that you consider the most relevant for the position, and two letters of reference. The application will be submitted through the University’s electronic recruitment system by clicking “Apply now” link. Applicants who are currently employed by the University of Helsinki are requested to submit their application via the SAP Fiori portal at https://msap.sap.helsinki.fi. The deadline for applications is 30 October 2023. Applications will be considered on a rolling basis until a suitable candidate is found.
For further information on the position, please contact Eliisa Kekäläinen (eliisa.kekalainen(at) helsinki.fi).
For information on the recruitment process, please contact HR Specialist Marja Meresto (hr-ltdk (at) helsinki.fi).
Selected publications from Kekäläinen lab:
Hetemäki I, Kaustio M, Kinnunen M, Heikkilä N, Keskitalo S, Nowlan K, Miettinen S, Sarkkinen J, Glumoff V, Andersson N, Kettunen K, Vanhanen R, Nurmi K, Eklund KK, Dunkel J, Mäyränpää MI, Schlums H, Arstila TP, Kisand K, Bryceson YT, Peterson P, Otava U, Syrjänen J, Saarela J, Varjosalo M, Kekäläinen E. Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells. Sci Immunol. 2021 Nov 26;6(65):eabe3454. doi: 10.1126/sciimmunol.abe3454.
Sarkkinen J, Dunkel J, Tuulasvaara A, Huuskonen A, Atula S, Kekäläinen E, Laakso SM. Ectopic germinal centers in the thymus accurately predict prognosis of myasthenia gravis after thymectomy. Mod Pathol. 2022 Sep;35(9):1168-1174. doi: 10.1038/s41379-022-01070-2.
Kleino I, Nowlan K, Kotimaa J, Kekäläinen E. Optimising protein detection with fixable custom oligo-labelled antibodies for single-cell multi-omics approaches. Biotechnol J. 2022 Jun;17(6):e2100213. doi: 10.1002/biot.202100213.
Nguyen NA, Huang X, Cabrera LE, Pekkarinen PT, Nowlan K, Strandin T, Kantele A, Vapalahti O, Heinonen S, Kekäläinen E. A comprehensive assessment of four whole blood stabilizers for flow-cytometric analysis of leukocyte populations. Cytometry A. 2023 Apr;103(4):313-324. doi: 10.1002/cyto.a.24700. Epub 2022 Nov 1. PMID: 36279192.
Lusila P, Toivonen A, Jarva H, Vettenranta K, Lehtimäki S, Kekäläinen E. FASCIA Method in the Assessment of Lymphocyte Mitogen Responses in the Laboratory Diagnostics of Primary Immunodeficiencies. J Clin Immunol. 2023 Apr;43(3):653-661. doi: 10.1007/s10875-022-01417-z.
The Faculty of Medicine promotes high quality scientific research. It provides research-based undergraduate and postgraduate education in medicine, dentistry, psychology and logopedics, and an international Master’s Programme in Translational Medicine. It also offers psychotherapist education. In addition to its teaching and research activities, the faculty serves as a significant expert organisation in the healthcare sector and contributes to the discourse on ethics in the field. The faculty aims to be one of the best medical research faculties in the world, while reinforcing its status as a distinguished institution of multidisciplinary education in healthcare.
The Faculty of Medicine at the University of Helsinki constitutes the academic medical centre together with HUS Helsinki University Hospital and the Helsinki Institute of Life Science (HiLIFE). This medical centre has been successful in international comparisons, ranking among the top 10 medical campuses in Europe and the top 50 globally.
Research Programs Unit (RPU) of the Faculty of Medicine consolidates demonstrated research excellence, with focused research programs addressing the greatest challenges in human health.
3.9.2023 | Avoimet työpaikat
https://www.linkedin.com/jobs/view/3706052115
About the job
INVITATION FOR APPLICATIONS
Postdoctoral researcher
We are looking for a skilled postdoctoral fellow with a background in neuroscience and/or human stem cell based neuronal models at the Institute for Molecular Medicine Finland FIMM , Helsinki Institute of Life Science, HiLIFE in the research groups of Professor Aarno Palotie ( Research Group Palotie ) and Dr. Olli Pietiläinen ( Research Group Pietiläinen ). The position is part of a research program that aims to discover biological mechanisms in schizophrenia and related neuropsychiatric disorders. The program bridges multidisciplinary group of researchers in the interface of genetic discoveries and multi-omic molecular biology using cell collections from over 6000 sequenced participants. The project combines state-of-art functional genomics and experimental cell biology approaches in human stem-cell derived neuronal models to discover how genetic risk factors identified in the disorders mediate their causative effects in human cells. The Pietiläinen laboratory is based at the Neuroscience Center and has close links with the Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard ( https://www.broadinstitute.org/stanley ). The Pietiläinen group is located at the Meilahti biomedical campus in Helsinki and is closely linked with research groups at the HiLIFE Institute for Molecular Medicine https://www.helsinki.fi/en/hilife-fimm (HiLIFE-FIMM) and the Faculty of Biological and Environmental Sciences https://www.helsinki.fi/en/faculty-of-biological-and-environmental-sciences . HiLIFE-NC offers a inspiring environment to solve fundamental challenges of brain functions as part of the multidisciplinary HiLIFE infrastructure https://www.helsinki.fi/en/helsinki-institute-of-life-science at the university of Helsinki. In Pietiläinen group you will be part of a striving scientific community utilizing state of the art technologies in genomics and cell biology for scientific discoveries of the brain.
Role description:
We are seeking a postdoctoral researcher to work on a multidisciplinary project that utilizes human induce pluripotent stem cells (iPSC) to model cellular processes involved in neuropsychiatric disorders. The primary goal is to use known genetic risk variants to identify quantifiable cellular phenotypes that underlie neuropsychiatric disorders. To this end we apply high-throughput multiple omics approaches such RNA sequencing and proteomics that are complemented by experimental molecular cell biology approaches in the in vitro model systems, including cellular assays and gene editing techniques in isogenic cell lines. We are looking for a person for planning, conducting, and co-supervising molecular biology and cellular experiments in human iPSCs.
Key Requirements
We are looking for a highly motivated and creative person with a primary interest in molecular cell biology using human iPSC derived neuronal models to discover mechanisms in neurological disorders, and to work in multidisciplinary team of clinical, wet lab, and computational scientists. Candidates should have a PhD in neuroscience or molecular and cell biology with experience in iPSC derived neuronal models. We require previous experience and skills in cell culture, molecular cell biology, iPSC models, and neural differentiation. The ideal candidate will have experience in these areas, and an interest in translating genetic discoveries into functional biology. Any previous experience in analysing and processing genomic and omic data is considered an advantage. The position is available from September 2023 onwards, or earlier, if required. It is a two-year fixed-term position, with a possibility of extension. Trial period of 6 months will be applied.
The salary will be based on level 5 of the demands level chart for teaching and research personnel in the salary system of Finnish universities. In addition, the appointee will be paid a salary component based on personal performance with the overall starting salary amounting to approximately 3600-4500 EUR per month, depending on the qualifications and previous relevant research experience of the candidate.
Please submit your application via the University of Helsinki Recruitment System by clicking the ‘Apply for the position button’ below. If you need support with the recruitment system, please contact recruitment@helsinki.fi.
Please attach the following documents to your application as a single PDF file:
- CV (including publications)
- cover letter (maximum 1 page) that details your past experience and motivation
- contact details of at least two references
The deadline for applications is September 29th, 2023. Interviews will be conducted either in person or online. For more information on the position, please contact Dr. Olli Pietiläinen (olli.pietilainen@helsinki.fi).
University of Helsinki
The University of Helsinki (UH), founded in 1640, is a vibrant scientific community of 40,000 students and researchers. It is one of the leading multidisciplinary research universities and ranks among the top 100 international universities in the world. It is currently investing heavily in life sciences research. UH offers comprehensive services to its employees, including occupational health care and health insurance, sports facilities, and opportunities for professional development.
Helsinki Institute of Life Science
Helsinki Institute of Life Science (HiLIFE) is a new institute established in 2017 that supports high quality life science research across the University campuses and faculties. HiLIFE builds on existing strengths and new recruits and partnerships to create an attractive international environment for researchers to solve grand challenges in health, food, and environment. HiLIFE coordinates research infrastructures in life sciences and provides research-based interdisciplinary training.
Institute for Molecular Medicine Finland
The Institute for Molecular Medicine Finland (FIMM) is an international research unit focusing on human genomics and personalised medicine at the Helsinki Institute of Life Science (HiLIFE) of the University of Helsinki – a leading Nordic university with a strong commitment to life science research. As part of Academic Medical Center Helsinki in Meilahti campus FIMM collaborates locally with the Faculty of Medicine, Helsinki University Hospital and National Institute for Health and Welfare. FIMM is part of the Nordic EMBL Partnership for Molecular Medicine, composed of the European Molecular Biology Laboratory (EMBL) and the centres for molecular medicine in Norway, Sweden and Denmark, and the EU-LIFE Community
HiLIFE -Neuroscience Center
The Neuroscience Center is an international research unit within Helsinki Institute of Life Science (HiLIFE) of the University of Helsinki, a leading Nordic university with a strong commitment to life science research. The research focus of NC is on translational brain plasticity. We carry out research relevant for the human brain both in health and disease, and during development and aging, by applying versatile approaches and modern technology platforms. NC aims at making fundamental discoveries about brain functions and especially translate research findings into improvements in the treatment, prevention and diagnosis of psychiatric and neurological disorders. The research in NC spans across several scales from stem cell research and molecular neuroscience to systems and cognitive neuroscience in both animal and human models.The research groups of NC conduct research in neuroscience at the highest international level and actively apply the results for the benefit of the society. NC collaborates actively with other units of HiLIFE and faculties of the University of Helsinki, Helsinki University Central Hospital, and Neurocenter Finland.
3.9.2023 | Avoimet työpaikat
https://www.linkedin.com/jobs/view/3705965231
About the job
Bring the future of clinical diagnostics through genomic data analysis to hospitals and laboratories globally.
Many diseases that have historically been incurable or untreatable will become curable or even preventable in the future due to increased understanding of our genomic data. Solving biological problems from this perspective is one of humanity’s greatest challenges. Do you want to play a role in enabling that change?
Responsibilities
As an Application Scientists your main responsibility is to demonstrate the capabilities and benefits of Euformatics software to customers as well as provide technical support and consultation to them. From assisting in the design and implementation of customer workflows and analysis pipelines to provide training and education to customers on the use of Euformatics tools, you will be responsible for building strong relationships with existing and potential customers and channel partners around the world taking ownership of their customer journey and success with us.
You will collaborate with cross-functional teams, including Product Development, Sales, and Marketing, to drive product adoption and customer satisfaction. Staying current on industry trends and new technologies in human genetics is valued. We are growing rapidly, and so is the number of our distributors and customers – this is your chance to play your part in making genomic analysis a routine part of every diagnosis.
You could be speaking with a laboratory director in a university hospital in the Philippines in the morning or catching-up with a customer in South America to ensure they are getting the most out of our products. Depending on your background, skills and experience you will be primarily responsible for one region in the world complemented by some custom-picked markets of interest.
You will work with your colleagues to maintain the Euformatics customer base, and maintain a strong, long-lasting relationship with them.
Qualifications
You are someone who is at ease in front of customers and a pro with words. Our customers are located all around the world, and we work in English, so a good working knowledge of English is crucial and fluency in other European languages is considered valuable.
You have a strong understanding in the field of genetics and molecular biology, or can demonstrate from previous experience that you are able to learn complex and new ideas quickly and effectively to be able to discuss with customers.
You understand the value of and can demonstrate experience of building trust with key stakeholders and are able to take initiative to solve customer problems.
You ideally have a doctoral degree and experience in a customer support role, but if you can convince us that your combination of skills and experience are the right fit then we are more interested in that than a degree. Most importantly, we value the priority and speed to keep customers satisfied topped with supporting your colleagues.
Work environment
We play the infinite game here at Euformatics. And occasionally some ping pong as well. In order to succeed in a complex and difficult field we need to work with people that commit to our mission and are in this for the long term. We are looking for people that want to make a difference and have the drive to make a long-lasting change. If this resonates with your ambition, please get it touch. We would love to hear from you!
3.9.2023 | Avoimet työpaikat
https://www.linkedin.com/jobs/view/3703121566
About the job
MIKÄ SINULLE ON TÄRKEINTÄ TYÖSSÄSI?
Meille tärkeintä on aina ihminen. Potilaat, joiden elämänlaatua ja toimintakykyä hoitomme tukevat. Terveydenhuollon ammattilaiset, joille kehitämme lääketieteen huippua edustavia ratkaisuja. Työntekijät, joille tarjoamme merkityksellistä työtä.
AbbVie on osaavien ihmisten yhteisö. Sinä tuot siihen oman arvokkaan panoksesi ja saat tilaisuuden oppia muilta huippuammattilaisilta. Yhteisöllinen yrityskulttuurimme hyväksyy ihmiset yksilöinä ja tukee jokaisen henkilökohtaista kehittymistä.
Onnistumisestamme työyhteisönä kertoo omalta osaltaan sijoittumisemme vuosi vuoden jälkeen parhaiden joukkoon Great Place to Work -tutkimuksessa.
Nyt etsimme Lääketieteelliselle osastollemme Sinua asiakaslähtöinen, kokenut
MEDICAL ADVISOR
Vastuullasi on tuottaa ja jakaa lääketieteellistä tietoa sekä antaa tieteellistä tukea niin ulkoisille kuin sisäisille asiakkaillemme. Toimit dermatologian ja reumatologian terapia-alueilla vastaten psoriaattisten sairauksien (iho- ja nivelpsoriaasin) portfoliostamme. Olet tiiviisti yhteydessä asiakkaisiimme ja rakennat kontakteja kyseisten terapia-alueiden asiantuntijoihin Suomessa. Toimit yhteistyössä AbbVien tiimin ja terveydenhuollon ammattilaisten kanssa hoitokäytäntöjen parantamiseksi. Varmistat pysyväsi alan tuoreimman tiedon tasalla seuraamalla tieteellisiä julkaisuja sekä osallistumalla kongresseihin ja seminaareihin. Jaat tietoa ja koulutat sekä sisäisiä että ulkoisia sidosryhmiä tuoreesta tutkimustiedosta vastuualueellasi. Ymmärrät modernin Medical Affairs -työskentelyn pääpiirteet ja olet halukas rakentamaan uusia yhteistyötapoja sekä kehittämään itseäsi ja tiimisi toimintaa alati muuttuvassa toimintaympäristössä. Työskentelet tiiviissä yhteistyössä lääketieteellisen osaston kollegojen, myynti- ja markkinointiosaston sekä Market Accessin kanssa. Raportoit Immunologian Head of Medical Affairsille.
Odotamme sinulta kokemusta lääkealalta sekä jatkuvasti muuttuvan lääkealan ympäristön tuntemusta. Tehtävä edellyttää lääketieteellistä, luonnontieteellistä tai muuta soveltuvaa ylempää korkeakoulututkintoa sekä vahvaa tieteellistä orientaatiota. Taustaltasi voit olla esimerkiksi lääkäri, proviisori tai biotieteiden asiantuntija. Tieteellinen jatkokoulutus on edellytys tehtävässä menestymiselle. Dermatologian ja/tai reumatologian tuntemus katsotaan eduksi. Itsenäisen ja ennakkoluulottoman työskentelyn ohella tarvitset vahvoja vuorovaikutus- ja tiimityöskentelytaitoja sekä valmiutta toimia matriisiorganisaatiossa. Oleellisen tiedon hahmottaminen alan tutkimusartikkeleista ja kirjallisuudesta sekä tiedon selkeä ja ymmärrettävä kommunikointi sekä suomeksi että englanniksi mahdollistavat työssä menestymisen. Olet kiinnostunut työskentelemään kaupallisessa ympäristössä ja vaikuttamaan potilaiden hoitoon yhteistyössä alan asiantuntijoiden kanssa. Olet parhaimmillasi uusien mahdollisuuksien edessä.
Tarjoamme sinulle laaja-alaisen tehtävän, jossa pääset vaikuttamaan vastuullisella ja merkityksellisellä toimialalla osana menestyvää kansainvälistä yritystä. Tueksesi saat osaavat kollegat ja dynaamisen työyhteisön. Tuemme oppimista ja tarjoamme mahdollisuuden kehittyä ja kehittää osaamista työssäsi.
Kiinnostuitko? Lisätietoja tehtävästä antaa Piia Vehviläinen, Head of Medical Affairs Immunology, 5.9. klo 11-12, 12.9. klo 11-12:30 ja 15.9. klo 12-13, puh. 050 593 5502. Voit hakea tehtävään viemällä CV:si ja hakemuksesi rekrytointijärjestelmäämme palkkatoiveella varustettuna viimeistään 17.9.2023 mennessä.
AbbVie on yksi maailman suurimmista lääkeyrityksistä, joka kehittää hoitoja vakaviin sairauksiin, keskittyen immunologisiin ja neurologisiin sairauksiin, onkologiaan ja hematologiaan sekä silmäsairauksiin. Tavoitteemme on parantaa vakavien sairauksien kanssa elävien ihmisten elämänlaatua. Terveydenhuollon ammattilaisille tavoitteenamme on tarjota lääkeluokkansa parhaita tai uusia vaikutusmekanismeja hyödyntäviä ratkaisuja. Haluamme olla lääkealan paras ja kiinnostavin työpaikka. Suomessa työntekijöitä on noin 100 ja toimistomme sijaitsee Helsingin Pasilassa. Potilaskeskeinen ajattelumme kiteytyy mottoomme ’Aina ihminen’.
AbbVie is an equal opportunity employer including disability/vets. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a disabled veteran, recently separated veteran, Armed Forces service medal veteran or active duty wartime or campaign badge veteran or a person’s relationship or association with a protected veteran, including spouses and other family members, or any other protected group status. We will take affirmative action to employ and advance in employment qualified minorities, women, individuals with a disability, disabled veterans, recently separated veterans, Armed Forces service medal veterans or active-duty wartime or campaign badge veterans. The Affirmative Action Plan is available for viewing in the Human Resources office during regular business hours.