Are you looking to join a dynamic, innovation-driven, international company, building a better future for us all? UPM leads the forest based bioindustry into a sustainable, innovation-driven, and exciting future. The competence, integrity and drive of our people make us unique. We live by our values – trust and be trusted, achieve together, renew with courage.
We are now looking for a Quality Manager to join our Biomedicals team in Helsinki or Lappeenranta, Finland.
Greetings from your future colleagues
“We are looking for a diligent professional with a solid experience in ISO 13485 to maintain our QMS and also to help leading the implementation of FDA and GMP compliance.” – Johana Kuncová-Kallio, Director, Biomedicals
“UPM proprietary nanocellulose technologies open a wide range of business opportunities in the biomedical field. Together with our professional and enthusiastic team, you will play a key role in securing the product quality and regulatory compliance and also have a possibility to participate in new business development.” – Kari Luukko, Director, QA Biomedicals
What You’ll Do
You share the vision for our products and for your part are responsible for its high-quality execution, the strategy implementation, and the roadmap development
You maintain and develop our ISO 13485 quality management system (QMS) in accordance with applicable regulations
You manage and develop QMS processes such as annual planning, non-conformities (NC) treatment, CAPA, change control and supplier management
You manage the process of legislation and standards monitoring
You maintain and develop UPM Biomedicals’ QMS database
You support and steer the team members in daily quality operations such as quality control, document management, NC and CAPA processes, design and development
You plan and co-ordinate management reviews, personnel trainings, as well as internal and external audits
You are the main contact for our notified body
You will be responsible for regulatory compliance on general level and support our teams in product-specific compliances. You will also participate in risk management processes of our products
You manage the regulatory strategy process of our products’ global market expansions and collaborate with our business developers and product managers
Who You Are
You have a university science degree and minimum if 5 years in a managerial role within quality management systems and regulatory affairs with focus to medical devices, ideally biomaterials rather than diagnostics or software
You have a deep understanding and working knowledge of ISO 13485, QC, GMP, MDR and FDA practices and document management. Your documentation practices are exact and persistent
You have proven business acumen and working knowledge of the industry and supplier base
You have excellent communication and problem solving skills
You are positive thinking, solution oriented, multitasking, persistent and proactive team player
You are fluent in written and spoken English. Finnish is seen as a benefit
Seen as a benefit:
You have previous experience of medical device or in vitro medical device product development for the Clinical market
You have previous experience in management of clinical trials
You know medical device registration processes in different territories
This Is What We Offer For You
Meaningful job: We are proud of what we do. Our work highlights the expertise of our personnel, the high quality of our products and the company’s values.
Inspired and motivated teams: We have highly skilled workforce. We are a multifaceted, international organisation that works as a team to achieve our shared objectives.
Development opportunities: With us you can build up your expertise. We provide opportunities to support your development throughout every stage of your career.
Responsibility for people and environment: Our ethical principles embrace people as well as the environment. We are always striving to build a more sustainable future.
Additional Information
At the beginning (first 2 years), the job requires intensive presence in Finland (Lappeenranta or Helsinki) to adapt Biomedicals operations, later the location is negotiable in UPM sites in Europe.The recruitment will be done in cooperation with our recruitment partner George James Ltd.For more information, please contact Kari Luukko, Director, QA Biomedicals on +358400259866 at the following times:
December 15th 2022 9-11 a.m. EET
January 5th 2023 from 9-11 a.m. EET
January 12th 2023 from 9-11 a.m. EET
Please send your application via link latest by 15.01.2023. We will start going through the applications already during application period so please submit your application as soon as possible.For support with submitting your application, please contact the HR Service Center at careers@upm.com or tel. +358204146600.A security background check may be performed for those selected to UPM positions, in accordance with the company recruitment guidelines and the Security Clearance Act 726/2014.UPM is a non-smoking workplace in Finland.
UPM Biomedicals is the forerunner in producing high quality nanofibrillar cellulose for medical and life science applications. More than 300 patents protect the existing and future products that rely on the Finnish birch pulp. We actively collaborate with universities, research centres and key industrial partners on innovations and products in the field of high throughput drug screening, personalized medicine, advanced cell therapies, 3D bioprinting, tissue engineering and wound care. www.upmbiomedicals.com
When you’re part of Thermo Fisher Scientific, you’ll do challenging work, and join a team that values performance, quality and innovation. As part of a successful, growing global organization you will be encouraged to perform at your best. With revenues of more than $40 billion and the largest investment in R&D in the industry, we give our people the resources and chances to create significant contributions to the world.
Location/Division Specific Information
Location: – Remote / Field within EuropeDivision: Genetic Sciences Division – Human Identification (HID)
Discover Impactful Work:
Join us as a Field Applications Specialist (FAS) and assist us in our mission to become the world leader in serving science. This multifaceted position involves providing scientific training, guidance, application support and troubleshooting for our customers in Russian-speaking countries.
A day in the Life:
Deliver on-site and remote scientific application support & training support to our customers on our HID products.
Supporting our customers with the implementation of new products, applications or workflows.
Diagnose & resolve product performance problems and customer queries/complaints by phone, email or onsite.
Work with sales representatives on sales calls to customer laboratories to provide technical and applications assistance in response to customer inquiries.
Assist the regional sales team in the development of accounts by giving technical seminars and presentations that promote the use of our products.
Providing pre-sales support activities like product demonstrations, user meetings or seminars.
Visit and represent our company on scientific or commercial meetings, conferences, trade shows, congresses, etc.
Establish contacts to key opinion leaders in the field and develop local references.
Maintain up-to-date technical expertise and in-depth knowledge of our product portfolio and scientific developments in the forensic DNA-identification workflow.
Become a strong internal Voice of Customer by providing customer feedback on our products to local and European Sales & Marketing.
Build trust with our customers and excel in customer service.
Keys to Success:
Education
Degree in Biology, Biotechnology, Biomedical Sciences, Genetics, Molecular Biology, Biochemistry or similar (Masters or PhD preferred)
Experience
Extensive technical hands-on experience (+5 years) in a forensics lab environment such as data analysis and/or research & development.
Previous experience in a support / training-related position or hands-on experience with Thermo Fisher Scientific HID technology is appreciated.
Knowledge, Skills, Abilities
High degree of technical competence & confidence.
Able to connect with and support people optimally with varying levels of technical knowledge and expertise.
Customer-centricity with the emotional intelligence to understand customer concerns and aware of markets, trends and competitors.
Good computer (especially MS Office) and/or IT skills and have an interest for groundbreaking innovation and technology.
Excellent communication & presentation skills.
Fluent Russian and English language skills – oral and written.
Willingness to travel internationally (mainly Russian-speaking countries / CIS with the exception of Russia and Belarus; and within Europe).
Valid driver’s license.
We are offering an employment with an innovative, growing organisation with outstanding career and development prospects and an exciting company culture which stands for integrity, intensity and innovation. The role comes with a competitive salary plan, company pension scheme, bonus plan, company car and further employee benefits.
Interested? Please apply in English language.
Our Mission is to enable our customers to make the world healthier, cleaner and safer. Watch as our colleagues explain 5 reasons to work with us. As one team of 100,000+ colleagues, we share a common set of values – Integrity, Intensity, Innovation and Involvement – working together to accelerate research, solve complex scientific challenges, drive technological innovation and support patients in need. #StartYourStory at Thermo Fisher Scientific, where diverse experiences, backgrounds and perspectives are valued.Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.
Are you a recent graduate and do you have less than 6 months clinical experience? Did you study in the life sciences/data sciences/data analytics/clinical/nursing area?
The Accelerated Program of Education, Exposure, and Experience for CRAs (APEX CRA) provides foundational clinical research training – including project and system experience – to new CRA hires who are recent college graduates and have less than a year of monitoring experience.
Through this program, you’ll transform into a credible and experienced CRA I. As you progress, APEX CRAs perform billable project tasks to support the CRAs and Clinical Operations Leads (COLs) with a focus in three developmental areas: Project Support, Initiation CRA support, and Site Facing support. You’ll be required to complete the ACRP Entry Level Knowledge Assessment and are enrolled in a 1-year membership to the ACRP.
You’ll also work closely with CRAs to gain exposure to and experience with the CRA role and its responsibilities across a period of three to six months. During this experience, you’ll have the opportunity to practically apply in-class concepts with day-to-day application by working with clinical systems including Clinical Trial Management Systems (CTMS), Electronic Data Capture, Safety Information Systems, and TMF platforms, and benefit from both instructor-led trainings and ongoing coaching and support of Line Managers and COLs.
Finally, APEX CRAs accompany CRAs for observational and co-monitoring support on-site or during remote visits which combines learning for the APEX CRAs and workload aid for their CRA colleagues. Upon completion of the program, you’re well-positioned to independently function within the CRA role and to immediately begin successful monitoring!
Minimum Bachelor’s degree in life sciences/data sciences/pharmacy/nursing or other related discipline
1 year or less of monitoring/clinical experience
Complete Finnish language proficiency
Strong interpersonal, written, and verbal communication skills within a matrixed team
Experience working in a self-driven capacity, with a sense of urgency and limited oversight
A client-focused approach to work and flexible attitude with respect to assignments/new learning
The ability to manage multiple tasks, evaluate unpredictable scenarios and achieve project timelines while applying your understanding of study protocol(s)An honest and ethical work approach to promote the development of life changing treatments for patients
Strong computer skills and aptitude to learn quickly
Aurealis Therapeutics is a Swiss-Finnish private biopharmaceutical company focusing on the development of a 4-in-1 synthetic biology, cell and gene therapy platform to address unmet medical needs in three therapy areas: chronic wounds, oncology, and inflammation.
We at Aurealis Therapeutics are looking for aMedical Monitor for a permanent-term contract in Kuopio or potentially other location in Finland, the Netherlands, Germany, or Switzerland. The start date of the job is negotiable, but we wish you could start during the first quarter of 2023. You will be working full-time.
We are looking for a team player for the medical monitoring and drug safety management of the company. As a Medical Monitor, you are responsible for medical and safety aspects of clinical development, advising and consulting on safety event evaluation, providing physician-level opinions on multiple trials and sites, consulting on protocol design, patient safety concerns, deciding if a specific adverse event requires un-blinding, mediating between sponsor, CRO and trial sites, reviewing whether concomitant medications and adverse events are coded and reported properly, examining the protocols of a clinical study, planning and initiating a trial, dealing with the data (analysis, interpretation, exploration). You are also responsible for pharmacovigilance/drug safety (Drug Safety Officer).
Your previous work experience and knowledge defines your position and responsibilities, so you have the opportunity to affect your role. Successful candidate for this role must be able to communicate efficiently in English.
We hope that you have at least +2 years of experience in similar roles and in depth, hands-on experience and understanding of clinical trial execution and follow-up. You have a degree in Medicine (MD). Working experience in chronic wound indications is an advantage, but not a must. You would be reporting to our Chief Medical Officer, and working closely with the clinical and regulatory teams and with external service providers (CROs). You are collaborative, highly organized and enjoy working with different systems. If so, you might be our new colleague!
Experience and skills required:
Overall knowledge and experience of the drug development process, clinical trial conduct, data management, drug safety, and biostatistics
Deep knowledge of relevant regulations e.g., ICH/GCP/GVP, EMA, and FDA guidelines
Excellent organizational, decision making and project management skills
Experience in working with software programs (EDC, eTMF, etc.)
We will offer you a position in an international and dynamic working environment where you have the opportunity to develop your career path. Join our team!
If you are interested in the position, please fill-in the application at https://aurealistherapeutics.com/medical-monitor/. We will be interviewing during the application time.
If you have any questions regarding the position, please contact Maija Rusi, our Financial and Administrative Director, by email at maija@aurealistherapeutics.com
Biovian on vahvasti kasvava turkulainen bioteknologiayritys. Tarjoamme sopimusvalmistusta, -analysointia ja prosessikehitystä biotekniikkayrityksille, jotka kehittävät innovatiivisia geeniterapioita tai biofarmaseuttisia tuotteita. Saatamme asiakasprojekteja laboratoriosta kliiniseen potilaskäyttöön asti taidolla, innolla ja sydämellä – tämä on meillä Manufacturing Happiness.
Haemme Analytical Scientistiä HPLC-tiimiimme
Yhtiön kasvaessa haemme vahvistusta laadunvalvontalaboratoriomme. Analytical scientist tehtävässä päävastuusi on HPLC analyysien suunnittelu, validointi, tarkastaminen, tulosten raportointi ja työn ohjaus. Lisäksi osallistut analyysimenetelmien kehittämiseen, laboratorion yleistoimintoihin ja toimit asiantuntijana asiakaspalavereissa. Analysoitavat tuotteet ovat pääasiassa proteiineja, joten aikaisempi työskentely vastaavien tuotteiden parissa on eduksi.
Päätehtäväsi on
– Toimia HPLC-analytiikan asiantuntijana ja kehittää työtä. – Projekteihin liittyvä raportointi, dokumentointi ja työohjeiden kirjoitus. – Vastata työn aikatauluttamisesta ja tarkastaa analyysien tulokset. – Opastaa HPLC-analyysien tekijöitä. – Toimia GMP-ohjeistuksen mukaisesti. – Osallistua asiakaspalavereihin asiantuntijana.
Työssä onnistuaksesi
Odotamme sinulta laajaa työkokemusta HPLC-analytiikasta. Sinulla on soveltuva ylemmän korkeakoulun tutkinto (esim. biolääketieteestä tai biokemiasta) sekä käytännön kokemusta analytiikasta. Olet tottunut dokumentoimaan ja kirjoittamaan raportteja englanniksi.
Toivomme, että sinulla on vahvaa osaamista jollakin alla mainitusta osa-alueesta sekä asiantuntemusta useimmista niistä:
Olet työskentelytyyliltäsi tarkka, järjestelmällinen, reipas ja toimelias henkilö. Sinulla on myös hyvät vuorovaikutus- ja ryhmätyötaidot. Toivomme sinulta myös joustavaa työotetta sekä kykyä työskennellä itsenäisessä tehtävässä.
Työohjeet ja dokumentointi tehdään englanniksi, joten toivomme sinulta hyvän suomen kielen taidon lisäksi myös hyvää englannin kielen taitoa.
Mitä sinä saat meiltä?
– Tarjoamme sinulle merkityksellisiä ja vastuullisia työtehtäviä lääkkeiden ja biologisten prosessien parissa. – Pääset osaksi huipputiimiämme, joka koostuu monialaisista asiantuntijoista. – Saat hyvän perehdytyksen tehtävään ja mahdollisuuden ammatilliseen kehittymiseen monipuolisten tehtävien kautta. – Saat viihtyisän työpaikan, jossa työntekijöitä arvostetaan, sekä hyvät henkilöstöedut – tarjoamme työntekijöillemme esimerkiksi laajan työterveyshuollon, terveysvakuutuksen sekä hyvinvointi- ja liikuntaedun.
Työtehtävä on kokoaikainen ja vakituinen. Työtä tehdään Turussa Kupittaalla, jossa toimipisteemme sijaitsee. Jatkossa sinun on mahdollista työskennellä myös etänä, toivomme kuitenkin, että olet paikan päällä noin neljä päivää viikosta.
Kiinnostuitko?
Lähetä hakemuksesi (suomeksi tai englanniksi) palkkatoiveineen viimeistään maanantaina 16.1.2023.
Lisätietoja tehtävästä antaa QC Manager Anne Rokka, 050 576 3192 9.1.2022 klo 12-13 ja 12.1. klo 9-10.
Käymme hakemuksia läpi hakuaikana ja haastatteluja voidaan aloittaa jo ennen hakuajan umpeutumista.
Tule mukaan työskentelemään kanssamme tulevaisuuden biologisten lääkkeiden parissa ja muuttamaan ideoita tuotteiksi!
WWW-osoite https://biovian.com/ Yhteystiedot Riikka Laine, riikka.laine@biovian.com Työpaikan osoite Tykistökatu 6 A, 20520 TURKU Työ alkaa Sopimuksen mukaan Työaika kokoaikatyö Työn kesto yli 12 kuukautta Haku päättyy 16.01.2023 klo 23:59 Ilmoitus jätetty 29.12.2022 Ilmoitusnumero 11766715
Health Tech Top Expert-RekryKoulutus toteutetaan keväällä 2023 (20.2.-15.6.2023). Koulutus sisältää terveysteknologia-alan erityisosaamiseen liittyvää etäkoulutusta sekä käytännöllisen työssäoppimisjakson alan yrityksessä. Toteutat työssäoppimisen yhteydessä sinulle räätälöidyn kehittämistehtävän, jonka tueksi saat henkilökohtaista sparrausta. Koulutuksessa vahvistat osaamistasi mm. terveysteknologian toimialasta, laadun- ja riskienhallinnasta, kansainvälisestä liiketoiminnasta, myynnistä ja markkinoinnista, projektinhallinnasta sekä tuotekehityksestä. Koulutuksen avulla kehityt huippuosaajaksi terveysteknologian alalle!
Avoin paikka: Tekninen asiantuntija
Koulutuksen yrityskumppani, TopCon Healthcare Solutions etsii teknistä asiantuntijaa vastaamaan integraatioista. Topcon Healthcare tarjoaa uusimmat kokonaisvaltaiset ratkaisut silmien terveydenhuoltoon, joihin kuuluvat esim. multimodaaliset kuvantamislaitteet, eri valmistajien laitteisiin sopivat datankäsittelyratkaisut sekä etälääketiedeteknologia.
Teknisenä asiantuntijana vastaat integraatioiden toteuttamisesta ja kehittämisestä. Huolehdit teknisten järjestelmien pystyttämisestä, testaamisesta sekä käyttökoulutuksesta ja palautteeseen pohjautuvasta kehittämisestä. Hakijalta edellytämme soveltuvaa korkeakoulututkintoa sekä ohjelmointiosaamista ja aiempaa kokemusta integraatioiden toteuttamisesta. Työssäsi tarvitset hyviä kommunikointi- ja tiimityötaitoja sekä englannin kielen taitoa, sillä työkielemme on englanti. Tiimimme työskentelee Oulussa. Teemme yhteistyötä myös muualla Suomessa sekä maailmalla kuten New Jerseyssä ja Japanissa työskentelevien kollegoidemme kanssa.
Tavoitteemme on tarjota terveydenhuollon ammattilaisille älykkäitä, arvoa tuottavia ja tehokkaita teknologiaratkaisuja hoidon ja palvelun kehittämiseksi. Tarjoamme sinulle mielenkiintoisen tehtävän kiehtovalla terveysteknologian alalla, huiput työkaverit ja joustavan työympäristön. Jos koet olevasi etsimämme osaaja, hae mukaan ja kerro lisää itsestäsi!
Hakuehdot RekryKoulutukseen
Hakijan tulee olla työtön työnhakija, työttömyysuhan alainen tai osa-aikaisesti työskentelevä. Hakijoilta edellytetään korkeakoulututkintoa (ammattikorkeakoulu tai yliopisto) tai riittävästi muuta työkokemusta esimerkiksi seuraavilta aloilta:
Health Tech Top Expert-RekryKoulutus toteutetaan yhteistyössä Kasve Oy:n, paikallisten TE-palveluiden ja ELY-keskuksen kanssa. Hakuprosessi ja opiskelijoiden rekrytointi tehdään yhteistyössä Pohjois-Pohjanmaan TE-palveluiden kanssa. RekryKoulutus on osallistujalle maksuton.
Health Tech Top Expert-RekryKoulutus toteutetaan keväällä 2023 (20.2.-15.6.2023). Koulutus sisältää terveysteknologia-alan erityisosaamiseen liittyvää etäkoulutusta sekä käytännöllisen työssäoppimisjakson alan yrityksessä. Toteutat työssäoppimisen yhteydessä sinulle räätälöidyn kehittämistehtävän, jonka tueksi saat henkilökohtaista sparrausta. Koulutuksessa vahvistat osaamistasi mm. terveysteknologian toimialasta, laadun- ja riskienhallinnasta, kansainvälisestä liiketoiminnasta, myynnistä ja markkinoinnista, projektinhallinnasta sekä tuotekehityksestä. Koulutuksen avulla kehityt huippuosaajaksi terveysteknologian alalle!
Avoin paikka: Projektipäällikkö Koulutuksen yrityskumppani, M-Solutions hakee projektipäällikköävahvistamaan tiimiään. M-Solutions Oy tuottaa kokonaisvaltaisia ICT- ja tiedonhallintaratkaisuja asiakkailleen teollisuudessa ja pk-sektorilla. Projektipäällikkönä työskentelet tiiviisti asiakkaidemme kanssa ja tuet heitä toiminnan kehittämisessä. Vastaat projektien määrittelytyöstä asiakkaita osallistaen, esität oikeita kysymyksiä, haet ratkaisuja ja huolehdit kokonaisuuden toteutumisesta. Edistät työssäsi myös oman tuotekehityksemme tuloksena syntyneen tiedonhallintajärjestelmämme (M-IDIS) myyntiä. Työhön voi ajoittain kuulua myös matkustamista asiakkaiden luokse eri puolille Suomea tai ulkomaille. Hakijalta edellytämme soveltuvaa korkeakoulututkintoa, teollisuusyritysten prosessien tuntemusta sekä kokemusta tiedolla johtamisesta ja asiakasrajapinnassa työskentelystä. Järjestelmäkehityksen ja ICT-alan ymmärrys on etu. Tehtävässä menestyminen vaatii kykyä hahmottaa kokonaisuuksia ja tunnistaa ongelmia. Toivomme sinulta lisäksi hyvää suomen ja englannin kielen taitoa. Arvostamme lisäksi hyviä vuorovaikutustaitoja, ratkaisukeskeisyyttä ja oma-aloitteisuutta. Vuonna 2016 perustetun yrityksemme päätoimipaikka sijaitsee Pyhäjärvellä, lisäksi tarjoamme mahdollisuuden etätyöhön. Tule mukaan tiimiimme luomaan tulevaisuuden teollisuutta!
Hakuehdot RekryKoulutukseen
Hakijan tulee olla työtön työnhakija, työttömyysuhan alainen tai osa-aikaisesti työskentelevä. Hakijoilta edellytetään korkeakoulututkintoa (ammattikorkeakoulu tai yliopisto) tai riittävästi muuta työkokemusta esimerkiksi seuraavilta aloilta:
Health Tech Top Expert-RekryKoulutus toteutetaan yhteistyössä Kasve Oy:n, paikallisten TE-palveluiden ja ELY-keskuksen kanssa. Hakuprosessi ja opiskelijoiden rekrytointi tehdään yhteistyössä Pohjois-Pohjanmaan TE-palveluiden kanssa. RekryKoulutus on osallistujalle maksuton.
Hosting Institute: Afekta in collaboration with University of Eastern Finland
Gross salary: 4,663 euros (+Family allowance if applicable)
Project description:
The PhD project will focus on assessing the impact of lifestyle intervention on blood microsampling metabolite composition when compared to conventional plasma samples. The aim is to find robust biomarker candidates that would readily reflect the metabolic effect of the intervention and the responsiveness of the individual to the lifestyle intervention. The student will work on optimizing the analytics based on the inter-laboratory comparison of the various blood microsampling home-collection devices. The samples to be collected from the lifestyle intervention will be assessed with the chosen collection method and optimized liquid chromatography mass spectrometry conditions. The impact of the lifestyle will be assessed by the non-targeted metabolite profiling approach, as well as compound-centric investigation of target metabolites that have been linked with dietary and exercise response and reflecting also the composition and function of gut microbiota.
We offer an exciting position and a chance to do research in an intersection between industry and academia. Afekta Technologies Ltd. is a science driven company established in 2017. Afekta offers metabolomics analysis services for various research purposes across life sciences. We have specialized in metabolomics analyses related to food, nutrition, and gut microbiota. Afekta has experience in being a beneficiary in several Horizon 2020 projects including a previous Marie-Sklodowska-Curie Doctoral Network action (MSCA-ITN-ETN-action BestTreat). To learn more about Afekta please visit www.afekta.com.
Academic studies related to the position will be done in the University of Eastern Finland (UEF), which will also award the PhD. UEF is a multidisciplinary university with a strong focus on life sciences. UEF has around 16,000 students and 3,000 staff members. Office and laboratory spaces of Afekta Technologies are right next to the UEF campus in Kuopio. Finland, and Kuopio in particular, is a safe, clean and technology-driven place known for its superb education and welfare know-how. To learn more about UEF and the life in Finland visit https://www.uef.fi/en/life-in-finland.
For further information on the position, please contact CEO Dr. Olli Kärkkäinen (olli@afekta.com, +358 44 2432 322).
Key Requirements:
Applicants should have a strong scientific background in the research field of Chemistry, Biochemistry, Biomedicine, Pharmacy, Toxicology, Pharmacology, or a similar field.
The prospective ideal student needs to have hands-on experience in applying liquid chromatography mass spectrometry -based methods for analysis of compounds in biological samples. Experience in mass spectrometry data analysis and in method optimization and/or data analysis are key requirements as well. Interest towards precise laboratory work and experience in metabolomics data analysis are desirable and will be favourably viewed.
The project will involve international and intersectorial secondments/visits to other project partners in the network for the doctoral candidates to learn new skills and foster collaborations.
Orion is seeking a Molecular Modeller (an experienced computer-aided drug design scientist) to further develop our capabilities and push the boundaries of theoretical drug discovery research carried out in Research and Development organisation’s Computational Medicine Design (CMD) unit.
Description Of Position
The Molecular Modeller will work in the drug discovery projects linking and interfacing with biology and chemistry with both physics-based and data-driven perspectives. You will be in key position to drive the molecule discovery process from target validation to development candidate. For this, it is critical to constantly refine the best suitable strategy and toolbox for each project according to the evolving data landscape and define how to increase the target understanding and how to navigate the path of multiparameter optimization in modality design. The Molecular Modeller will collaborate closely with a broad range of scientists including other molecular Modellers in the CMD unit, medicinal chemists, biophysicists, pharmacologists and biologists.
You will be based in Espoo or Turku, Finland.
Description Of Unit
Orion is a globally operating Finnish company listed on the Helsinki Stock Exchange. Orion develops, manufactures and markets human and veterinary pharmaceuticals, active pharmaceutical ingredients and diagnostic tests for global markets. Orion’s pharmaceutical innovations are created within its R&D organization, including e.g., non-clinical research, clinical development, formulation development and medical affairs. The organization employs top professionals in the field of drug molecule discovery and development.
Medicine Design contributes to the drug discovery process of Orion R&D from target validation all the way to the candidate nomination. We are responsible for translating new drug targets to therapeutical modalities together with other line functions. Our scientists in biology, chemistry and computer-aided medicine design are key players in the multiple research programs driven by Orion’s therapy areas of Oncology and Pain. We also support our colleagues around R&D with our core competences.
We offer
We offer you great, highly professional & experienced colleagues and the opportunity to show your talent and challenge yourself with interesting tasks in a modern multidisciplinary environment. Computational methods play a key role in Orion drug discovery, so this is an opportunity to contribute to helping patients in need. Generous health and welfare benefits are available, as well as support for international relocation. Read more about R&D’s pipeline from here. Orion’s R&D Pipeline | Orion
Requirements
To be the successful Molecular Modeller in our R&D, you should have the following educational and professional work experiences:
Ph.D. from a suitable field, e.g., computational chemistry, bioorganic chemistry, biophysics, structural biology, computer science or biochemistry
Concrete post-doctoral or industrial experience (3+ years)
Broad experience in computational drug design, mastery of most ligand-based and structure-based approaches and their applications for medicine design
Solid understanding of fields relevant in the discovery process (e.g., medicinal chemistry, pharmacology, biochemistry, cell biology, structural biology, biophysics)
In addition, you are expected to bolster the research unit with in depth experience in at least one of the following aspects:
Application of large-scale modern data science, machine learning, cheminformatics and generative molecular design for drug discovery
Large-scale molecular dynamics simulations (e.g., free energy methods) for protein-ligand complexes
Solid track record of progressing modalities from hit identification through lead optimization to clinical candidate
Experience with commercial molecular modelling software platforms, data pipelining tools (e.g., Knime) and programming/scripting/data analysis/data visualization (e.g., Python) is desirable.
We expect from all scientists the ability to work both independently and in multidisciplinary teams consisting of in-house scientists and external collaborators. A demonstrated record of research productivity and excellent oral and written communication skills in English are expected.
Additional Information
Is this the position you have been waiting for? Please send your cover letter and CV by 1st January 2023 and let us know what inspires you! Please note that the application period is extended due to holiday season and interviews will take place in January 2023.
For additional information on the position, please contact Heikki Käsnänen, Head of Computational Medicine Design, +358 50 966 5279, during the following times: December 12th and 13th: 10 AM to 11 AM (EET).
Orion supports and assists international relocation.
Approved medical examination which also includes drug testing is required prior to the employment. We will also carry out a security clearance prior to the employment for the selected person. Orion Corporation operates in more than 30 countries, where we Orionees, 3300 in total, work in all kinds of positions. Among us there are Research Scientists, Laboratory Technicians, Engineers and IT Specialists as well as people working in Production, just to mention some examples. We offer diverse and responsible jobs to our personnel in a truly multi-disciplinary work environment. We encourage people to develop their competences and offer opportunities to affect the job description and creating their own career path at Orion. We are searching for top talents who are ready to share our passion for the work that we do.
The University of Helsinki is a leading university in Nordics and Europe and one of the top 100 international universities in the world. Doctoral researcher position is available in the Translational Pain Research group at Department of Physiology, Faculty of Medicine, led by Academy of Finland Research Fellow Dr. Vinko Palada.Dr. Palada s team investigates the bidirectional relationship between sleep and pain and circadian regulation of chronic pain by using the state-of-the-art methods such as high-throughput omics, molecular biology, drug library screens and the functional studies in experimental models. This is a new and exciting research field, with the goals to revolutionize our understanding of pain mechanisms and to develop novel therapies for pain relief. The group closely collaborates with Helsinki University Hospital and Karolinska Institute, Stockholm, Sweden. In 2022, Finland has been ranked as the happiest country in the world for 5th time in a row according to the annual World Happiness Report and was recently rated as the best country in the world for expat families.
Job Description
Neuropathic pain affects up to 8% of the general population and is one of the most challenging pain conditions to treat due to poor efficacy of the currently available drugs and comorbidities, particularly sleep disorders, which are insufficiently addressed in pain management. On the molecular level, both sleep and pain are under circadian control. As adaptation to 24h environment on Earth, our internal circadian clocks are reset daily to precisely 24h and disruptions in this pattern have been reported in sleep disorders, frequent in chronic pain. However, it is currently not known whether the clocks are disrupted also in painful conditions. The main aim is to access the effects of circadian disruption on pain intensity both in experimental models and in clinical cohorts. This may allow to establish the novel chronotherapeutic approaches for pain relief.
Key Requirements
We invite applications from highly qualified applicants with a MSc degree in neuroscience, biology and/or pharmacy/pharmacology. Previous experience in sleep and circadian research, expertise in animal work, EEG recordings, sleep scoring, surgical skills and behavioral tests are considered a strong merit for this position. Excellent communication and writing skills in English and ability to work in the international team setting are expected.
Application Requirements
Please send your application including a detailed CV (with a date of thesis defense, title of the thesis, previous academic/work positions, current position, academic distinctions and list of peer-reviewed publications), motivation letter (1 page) and three reference contacts as a single PDF file to the submission portal. The successful candidate is expected to apply for doctoral study rights in January 2023, for doctoral programme requirements please check the following link: https://studies.helsinki.fi/instructions/doctoral-study-rights-and-duration-studies
Contract And Work Benefits
Employment will start on January 1st 2023 as initially a 2 year position with a possibility of prolongation. For more information about working at the University of Helsinki and living in Finland, please see https://www.helsinki.fi/en/university/working-at-the-university. The salary will be based on demand level 2 of the Teacher and Researcher staff in the salary system of the Finnish universities.