Ajankohtaista

Åbo Akademi University invites applications for a fixed term position as a PhD Student in Cell Biology starting 1.4.2019 within SPACE-Project (42 months) and within BACE-Project (48 months)

Research group

The Cell Fate lab led by Professor Cecilia Sahlgren is focused on the
fundamental molecular mechanisms that guide cell fate and cell
organization in stem cell differentiation, tissue formation and in
disease such as cancer. Together with collaborators we utilize such
knowledge to develop material-based medical technologies to control
these mechanisms in regenerative and cancer therapies. Coordination of
cells through molecular cell signaling pathways is crucial for the
formation of functional tissues and signaling is often deregulated in
diseases such as cancer, allowing cells to acquire abnormal functions
and pathological remodeling of tissue architecture. The physical,
mechanical and chemical stimuli of the microenvironment also influence
cell signaling and cell fate decisions during development and disease
progression.

Project description

We are seeking 2 ambitious PhD candidates to join our projects on
Spatiotemporal activation of cell functions (SPACE) 1.4.2019-31.8.2022
or Bioelectronic activation of cell functions (BACE)
1.4.2019-28.2.2023. These projects form an interdisciplinary approach
bringing together researchers within experimental physics and
molecular biology, in order to activate Notch signalling on demand.
The Notch signalling pathway is a seemingly simple signalling system
where the interaction between a ligand at the surface of one cell and
a receptor at the surface of another gives rise to one active
signalling fragment, which regulates target gene expression. Notch is
involved in cell fate specification during development, usually by
facilitating binary cell fate decisions or by maintaining stem cell
fate. Perturbation of the signalling cascade is a contributing factor
in the development of various diseases. Strictly organised, both
spatial and temporal, expression of different receptors and ligands is
essential for proper development of different organs, with each
consecutive activation of Notch driving a specific morphogenic
process. The possibility of controlling Notch receptor activation by
regulating ligand dose and the specific timing of activation will
enable us to better understand different developmental patterns.

JOB REQUIREMENTS

We are accepting applications from enthusiastic and highly talented
candidates who are interested in a dynamic, stimulating and ambitious
environment to perform their research and share their scientific
knowledge.

We are looking for candidates that meet the following requirements

•The candidate should have a MSc in molecular biology, cell biology,
or an equivalent area

Personal qualities

We are seeking a driven and pro-active applicant with good
communication and interpersonal skills. The applicant should be
confident in working independently, but value developing good working
relationships both within the research group and with collaborators.
Knowledge of basic cell and molecular biological techniques (e.g.
mammalian cell culture, Western Blotting, PCR) is required. Knowledge
in e.g. biophysics, synthetic biology, chemistry or engineering (with
strong molecular background) is an asset.

CONDITIONS OF EMPLOYMENT

We offer

•A challenging job at a dynamic and ambitious environment and in an
enthusiastic international, interdisciplinary team.

•Access to world class infrastructure in proteomics, metabolomics,
functional genomics, bioinformatics and bioimaging.

•Support with your personal development and career planning.

•Gross monthly salary is in accordance with the salary system of
Finnish universities based on levels 2 – 4 of the job demand level for
teaching and research personnel. In addition, a salary component based
on personal work performance is paid.

•Doctoral training programme at Åbo Akademi University

SALARY

The salary for PhD Student is in accordance with the Finnish
University salary system for teaching and research personnel job
demand levels 2-4, where the work specific salary component is
2011,17-2507,62€ per month. In addition, there is a salary component
based on personal work performance, which is at most 50.00% of the
base salary.

APPLICATION

Please submit your electronic application with enclosures below
(Submit application, www.abo.fi/jobb). The closing date for
applications is March 19th, 2019 at 15.00 Finnish time.

A free-format letter of application (in English)
Copies of the bachelor’s and master’s degree diplomas, including the
study record (with grades)
Your CV (in English)
Copies of documents that support the candidates English language skills
Recommendation letter or contact details to references


CONTACT INFORMATION

For further information, please contact professor Cecilia Sahlgren,
group leader, Cell Biology, Faculty of Science and Engineering, Åbo
Akademi University, e-mail: cecilia.sahlgren@abo.fi or Marika
Sjöqvist, PhD, marika.sjoqvist@abo.fi

Link to add:
https://abo.rekrytointi.com/paikat/index.php?jid=179&key=&o=A_RJ&rspvt=7q8x3xyyvm8804cc8ws8soggkgs484w

Open post doc positions in Statistical Ecology and Population / Community Ecology in the Research Centre for Ecological Change – University of Helsinki

Open position for a postdoctoral fellow in the Matyas’ laboratory to work on the development of heroin and fentanyl vaccines at the Walter Reed Army Institute of Research (WRAIR), USA

There is an opening for a postdoctoral fellow in the Matyas’ laboratory to work on the development of heroin and fentanyl vaccines. The Post-Doctoral Fellow will support the Laboratory of Antigen and Adjuvant Research (LAAR) within the US Military HIV Research Program (MHRP) located at the Walter Reed Army Institute of Research (WRAIR) located in Silver Spring, MD, USA. HJF provides scientific, technical and programmatic support services to MHRP.

The fellow will conduct studies to support a Phase 1 clinical trial on heroin vaccine. This position also involves developing fentanyl vaccine, combination heroin-HIV vaccine, and adjuvants.

The position is with the Henry M. Jackson Foundation for the Advancement of Military Medicine in the laboratories located at the Walter Reed Army Institute of Research, Silver Spring, MD. Below is the link for the position: https://careers.hjf.org/jobs/3564690-postdoctoral-fellow

Bioinformatics specialist (MSc) – Genevia Technologies, Tampere

https://geneviatechnologies.com/bioinformatics-company/bioinformatics-jobs/

We are looking for a bioinformatics specialist to join the Genevia Technologies team for an EU funded project.

The successful applicant will be working as a part of our bioinformatics production team in various NGS data analysis tasks. As a small company we are able to offer you a great deal of flexibility and influence on your work. We strive to foster development of your skills and your professional growth to the direction that you choose!

Your responsibilities include:

• Integrating new analysis tools into our existing data analysis workflows
• Analyzing a wide variety of omics data
• Documenting the used analysis workflows
• Visualizing and reporting the results to our senior staff

What we offer:

• Learning commercially relevant genomics and bioinformatics technologies
• Gaining broad domain knowledge in biotechnology and life sciences generally
• Experience in commercial research and product development processes
• Working in a close collaboration with senior bioinformatics professionals
• Career advancement options to senior bioinformatics positions
• Flexible working hours
• Office in city center (Tampere, Finland)
• Competitive salary according to the EU funding scheme for early stage researchers (ESR), more information here

Required background:

• Master’s degree in bioinformatics, computer science or related field
• Programming experience with bash, R, and Python
• Experience in preparing scientific publications
• N.B. This project is funded by the EU and the funding instrument does not allow applicants with a PhD degree, or recent employment history in Finland (max 4 months in Finland within last 2 years)

If you feel like you might be just the person we are looking for, please send your application to info@genevia.fi by 17th of March with title: Work application: Bioinformatician.

Exciting PhD positions at the European Molecular Biology Laboratory (EMBL)

Job Description

The European Molecular Biology Laboratory (EMBL) invites you to apply for PhD positions in Heidelberg, Barcelona, Grenoble Hamburg, Hinxton (near Cambridge) and Rome.

Would you like to contribute your creativity to an international team of scientists from all disciplines focusing on basic research in the area of molecular life sciences? We invite candidates with background in Biology, Chemistry, Physics, Mathematics, Computer Science, Engineering and Molecular Medicine to apply.

EMBL opens the door to your scientific career: our students have an outstanding publication record, are a vital part of our global collaborations and receive their degrees jointly with our network of excellent partner universities in 17 different countries.

Our PhD positions come with generous fellowships, including broad health care benefits and pension access.

More information about the interview procedure can be found here: https://www.embl.de/training/eipp/application/interview_week/index.html

Application Instructions

Please apply online through
http://www.embl.de/training/eipp/application/index.html      

The registration deadline is 25 March 2019.
The deadline for submission of the online application is 1 April 2019.
Interviews will take place beginning of July 2019 in Heidelberg and a week prior at other EMBL sites.

Additional Information

EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation.
Successful candidates would start their work at EMBL latest by mid of October 2019.

For further information, see our web page or contact EMBL Graduate Office.

15 Early-Stage Researcher (ESR) positions for 3-year structured PhD projects are offered by a consortium of 11 participants in the Marie SkƗodowska-Curie Actions ITN project “SECRETERS”

Marie SkƗodowska-Curie Actions Innovative Training Networks (H2020-MSCA-ITN-2017)
“SECRETERS” “

15 Early-Stage Researcher (ESR) positions for 3-year structured PhD projects are offered by a consortium of 11 participants in the Marie SkƗodowska-Curie Actions ITN project “SECRETERS”.

http://www.finbionet.fi/Marie_Sk%C6%97odowska_Curie%20Secreters_ITN.pdf

Applications should be submitted as soon as possible, since different closing dates apply for different participating organizations. Eligible candidates are invited for an interview by Skype. Short-listed candidates will be invited for a recruitment symposium in May 2019 in Groningen, the Netherlands, for which travel costs and accommodation will be reimbursed.

PhD student and post doc positions open in plant developmental biology at the University of Helsinki

The University of Helsinki is an international scientific community of 40,000 students and researchers. It is one of the leading multidisciplinary research universities and ranks among the top 100 international universities in the world.

Helsinki Institute of Life Science HiLIFE is a new life science research institute forming an attractive international environment for researchers, and facilitating national and international partnerships in areas of research, infrastructures, and innovations. The university life science research institutes – Institute of Biotechnology, Institute of Molecular Medicine Finland FIMM, and Neuroscience Center – are included in HiLIFE as operative units.

PhD student and Post doc positions are available in the research group led by Ari Pekka Mähönen at Institute of Biotechnology (HiLIFE)/ Faculty of Biological and Environmental Sciences, University of Helsinki, Finland.

Vascular cambium produces xylem (wood) and phloem, and together with the cork cambium, which produces a protective layer at the surface called phellem, they provide thickness to plant organs. The goal of the group has been to understand the molecular regulation and cellular organization of vascular cambium. We have been utilizing lineage tracing techniques, molecular genetics, advanced microscopy and genomics as approaches to study the cambial cells in the model species Arabidopsis thaliana. Using these techniques, we recently identified stem cell organizer of the vascular cambium (Smetana et al. Nature 2019).

We are looking for post doc(s) and PhD student(s) to carry out an ERC Consolidator Grant -funded research line, in which we investigate growth dynamics and regulatory mechanism of the stem cells of cork cambium. We will also study how the two lateral meristems, cork and vascular cambia, together increase the thickness in plants. More information available in the lab website.

The topics of research projects will be discussed in detail during the interview of the selected candidates.

Applicants with strong background in developmental genetics, plant molecular biology and/or cell biology are encouraged to apply. Good communication skills and fluency in spoken and written English are required. Postdocs are also encouraged to develop their own research lines.

We provide an international and stimulating work environment. We offer a competitive salary based on previous qualifications, experience and personal performance in the position according to University of Helsinki regulations.

The deadline for applications is March 11th, 2019, or until suitable candidates are found. Please submit your application using the University of Helsinki Recruitment System via the Apply for the position link below. Applicants who are employees of the University of Helsinki are requested to leave their application via the SAP HR portal. The application should include personal data and contact information of at least two referees, as well as a single pdf-file containing: a motivation letter describing previous achievements, future career ambitions and motivation for this position (max 1 page), a CV (max 2 pages) and a publication list.

For more information about the positions, contact AriPekka.Mahonen(at)helsinki.fi. For technical support regarding the recruitment system, please, contact rekrytointi(at)helsinki.fi.

Here is a link to the application form for PhD student position. 

Here is a link to the application form for post doc position.

Open position for a Postdoctoral Research Assistant at University of Dundee (Cellular Medicine)

Duration of Employment: up to 36 months

We are recruiting for an exceptional individual to join us as a Postdoctoral Research Assistant within our team, to study immunometabolic actions of metformin. The post holder will work on a British Heart Foundation (BHF) funded project that aims to study ‘immunometabolic’ remodelling of monocyte and macrophage responses by metformin in cardiovascular disease. The work will mainly involve primary cell work, including proteomics, signalling analysis and other approaches to study cellular and molecular biological effects of the drug on immunity.

Our work in this area (Circulation, Circulation Research) has established that anti-inflammatory effects of metformin are exerted irrespective of diabetes status, through mechanisms that are different from existing anti-inflammatory drugs. Control of immunity through changes in metabolism- ‘immunometabolism,’ if it can be better understood, is recognised as a potential site of therapy even in nondiabetic age-related cardiovascular disease (CVD). To work towards this, the purpose of this proposal is to study effects of metformin on monocyte and macrophage biology, to develop a mechanism-based understanding of metformin’s anti-inflammatory actions. Timely insights from the recent CANTOS study, establishing a CVD group receptive to anti-inflammatory therapy, underlines translational potential.

You will be joining a dynamic and growing team working in open-plan lab space alongside other groups, all of us interested in basic science with translational potential. We will offer you experience in supervising students and although the majority of time will be based in Ninewells, Dundee, the post holder will require to have the ability to travel flexibly as this post includes a unique research stay in Finland as part of the group’s interest in internationalisation of diabetes and cardiovascular disease research networks. Previous experience in appropriate research techniques is desirable but training is available.

The University of Dundee enjoys an international reputation for excellence that attracts top-class students and academics from across the world – with over 140 countries represented in the University community. You will be based at Ninewells Hospital and Medical School, one of Europe’s largest teaching hospitals where the School of Medicine provides outstanding opportunities in medical education and training supported by world class research facilities.

Your priorities will include:

• Manage multiple strands of research work to meet deadlines
• Prepare progress reports delivering to PIs and collaborators
• Day-to-day supervision of students within the group
• Write up results for publication
• Visit Finland in year 1

Who we’re looking for:

• Someone with a PhD or equivalent experience
• Highly motivated to publish, already with a major contribution to at least one published paper
• Ability/interest in leading a small team (through supervision of students) to achieve research goals
• An interest in cardiovascular/diabetes research, ultimately to make life better for patients
• Willingness and ability to visit Finland for collaborative research stay

The calibre of research at Dundee is high, with 95 per cent of staff working in areas of national or international excellence. Dundee benefits from a developed network of inter-disciplinary researchers collaborating across various Schools across our community.

For further information about this position please contact Dr Graham Rena at g.rena@dundee.ac.uk. To find out more about Ninewells Hospital and Medical School please visit https://www.dundee.ac.uk/medicine/.

More information at https://www.jobs.ac.uk/job/BPX947/postdoctoral-research-assistant

Deadline for applications is March 3, 2019.

Post-doctoral researcher to work at the Atherosclerosis Research Laboratory at the Wihuri Research Institute, Helsinki

The Atherosclerosis Research Laboratory at the Wihuri Research Institute, located in Biomedicum Helsinki in Meilahti, is looking for a highly motivated post-doctoral researcher.

The Atherosclerosis Research Laboratory focuses on identifying novel methods to assess person-to-person differences in various atherogenic properties of lipoproteins, such as interaction of lipoproteins with proteoglycans and lipoprotein modification and aggregation. In a recent hypothesis-generating study we found a link between the presence of aggregation-prone LDL and atherosclerotic cardiovascular disease (ASCVD) death in a small group of patients having established atherosclerosis (https://academic.oup.com/eurheartj/article/39/27/2562/5049093).

The present research project aims at confirming this link. In addition, we will examine the metabolic factors that control LDL composition and aggregation using mouse models of atherosclerosis, cell culture systems, and in vitro studies. The ultimate goal of our research is to develop novel biomarkers that may facilitate identification of patients who are at increased risk for developing ASCVD.

The Atherosclerosis Research Laboratory led by Adj.Prof. Katariina Öörni is now seeking a post-doctoral researcher to participate in the studies. In particular, we are seeking a researcher with experience in mouse studies. The successful candidate has also experience in cell culture methods and knowledge of lipid and lipoprotein metabolism.

Experience and skills:

·         Ph.D. in biology, biochemistry, medicine or equivalent sciences

·         An excellent research track record

·         Experience in mouse studies

·         Experience in cell culture

·         Knowledge of lipid and lipoprotein metabolism

·         Excellent written and spoken English skills

The position is funded by the Academy of Finland and can be filled immediately. The position is initially funded for 18 months, but can be extended depending on the funding.

Please apply by sending motivation letter and CV in a single PDF file by e-mail to Adj. Prof. Katariina Öörni kati.oorni@wri.fi by February 25^th. The position will be filled as soon as a suitable candidate is found.

For further information, please contact Katariina Öörni at the above e-mail.

Postdoctoral position in structural biology at the University of Oulu

The University of Oulu in Northern Finland, with approximately 14,000 students and 3,000 employees, is an international, multidisciplinary research university with a rich pool of creative and intellectual talent. The strengths of the University include broad, multidisciplinary research interests, a modern research and study environment, and wide cooperation with international research and educational institutes (http://www.oulu.fi/university/).

An open postdoctoral research position is available in the field of structural biology of extracellular matrix proteins in the research group of Prof Lloyd Ruddock (http://www.oulu.fi/biocenter/groups/ruddock). Focus of the project is structural and functional studies of basement membrane proteins. The project includes structural biology, systems biology and protein-protein interaction studies.

The position is located at the Faculty of Biochemistry and Molecular Medicine (FBMM) (http://www.oulu.fi/fbmm/), whose mission is to perform internationally significant research and to deliver high-level undergraduate and postgraduate education in the fields of biochemistry and molecular medicine. The Faculty’s research focus areas are cell-extracellular matrix, protein science and cellular regulatory and metabolic networks and related diseases. Research at the Faculty is carried out in 14 research groups. The Faculty has ~200 employees, and approximately half of them are from abroad. Together with Biocenter Oulu (http://www.oulu.fi/biocenter/), the Faculty has put a great effort towards building a cutting-edge research infrastructure that includes state-of-the-art instrumentation for imaging, gene-modified mice, X-ray crystallography, and quantitative biochemistry. The Faculty has extensive collaborative national and international networks including Biocenter Finland and the ESFRI projects Instruct, EuroBioimaging, and Infrafrontier. We also partner in EU-Biostruct-X and Marie Curie Renaltract ITN and organize EMBO workshops and international symposia. The research group has well-established international collaborative networks and frequent access to synchrotron radiation.

Subject field and description of the position

Basement membranes (BM) are complex networks, comprising many essential and often large multi-domain proteins. BM are involved in embryo development, tissue homeostasis and in a wide range of disease states including tumour angiogenesis, fibrosis, nervous system injury etc. BM proteins are poorly studied at the structural level. This lack of structural data inhibits not only our understanding of the normal physiology of BM, but also our understanding of the pathology of a wide range of disease states and our ability monitor disease progression and to make rationale interventions to halt or reverse symptoms of the disease, including cell-based therapy. The research focus for the position will be structural and functional studies of BM proteins.

The details of the research project will be mutually agreed upon, based on the qualifications, interests, and expertise of the candidate.

The position is funded by the Academy of Finland. The initial duration of the position is 1 year and the funded position ends on April 30, 2020. After this, funding will be jointly applied to extend the contract. The starting date is May 1, 2019, or as soon as possible thereafter.

Required Qualifications and assessment

The successful applicant must hold a PhD degree in biophysics, structural biology, biochemistry or a related field. Candidates whose PhD thesis has been submitted by the application deadline will also be eligible. Experience with recombinant protein expression post-translational modifications, systems biology, X-ray crystallography and cryo-EM will be considered as assets.

·         Fluent oral and written English skills as well as good communication and teamwork skills are required. Demonstrated experience in writing scientific publications, potential in acquiring supplementary funding and teaching experience will be taken as merits. When assessing the applicant’s qualifications, issues to be considered will include scientific publications, supervision experience, activity in the scientific community and familiarity with the research field.

·         As part of the FBMM, duties may also include supervising scientific research of BSc, MSc and PhD students. Participation in teaching within the faculty curriculum is expected.

·         A four-month trial period will be effective in the beginning of the contract.

Salary

The salary is in accordance with the University salary system (for teaching and research personnel) levels 5 or 6. In addition, there is a share increase at most, 50% of the base salary, which is based on personal achievements and performance. The salary is in practice roughly 3,300 – 4,100 € / month, depending on qualifications, performance and experience.

Application Procedure

The following documents must be attached to the application (in English):

1) Curriculum vitae, including a list of publications and with the names and contact details of at least 2 referees

2) Brief description of research merits, experience and motivation

Applications, together with all relevant enclosures, must be submitted using the electronic application system by 11.3.2019. Applications sent by email will not be considered. (https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=1&id=00006878&lang=en)

Interview

The top candidates for the post may be interviewed and asked to present their scientific work and experience.

For further information regarding the filling of this post:

Prof Lloyd Ruddock, group leader, email: lloyd.ruddock(at)oulu.fi

Tiina Hurskainen, HR manager, email: tiina.hurskainen(at)oulu.fi