This
opportunity has arisen through Dr. Shintaro Katayama as a junior PI
supported by Jane and Aatos Erkko Foundation. The joint research groups
with Professor Juha Kere are base in the Folkhälsan
Research Center at Helsinki, Research Programs Unit at University of
Helsinki, and Department of Biosciences and Nutrition at Karolinska
Institutet.
The focus of the work is aimed at understanding where and when RNAs are regulated in various human developmental stages [*1] or the cell types [*2] to understand the disease
[*3] or to use the deregulated RNAs for
diagnosis [*4]. For the aim, the groups are willing also to develop new
molecular and/or bioinformatics methods [*5, 6, 7].
As
part of the joint research groups, there is a position available for a
PhD candidate studying RNA (not DNA) editing in human normal epidermal
cells and the model cells using high-throughput
sequencing at Folkhälsan Research Center and University of Helsinki.
The main duties will involve the establishment of a genome-scale
analysis pipeline or tools to map the RNA editing sites in human cells
using a nanopore sequencer as well as computational
analysis of the experimental results. The analysis includes the
integration of the other experimental results using other equipment or
methods to investigate the association between gene expression and RNA
editing.
The
successful candidates should have (or be close to completed) an MSc in
Bioinformatics, Biostatistics, Systems Biology, Computational Biology or
a related field. Experiences of an open-source
software package development will be plus. Applicants interested in any
of the above research areas will be considered.
Please send your application to shintaro.katayama(at)folkhalsan.fi latest Sunday March 15
2020. Please include a brief letter motivating your interest and
goals, a CV (2 pages, specifying your education and expertise in the
topics listed above), and a list of possible previous publications. The
selection processes will be conducted in April
and the post is available from summer 2020. The funds for this position
are available for 24 months in the first instance.
Selected publications:
*1 Töhönen, V. & Katayama, S. et al. Nat Commun6,
8207 (2015).
*2 Hirabayashi, S. & Bhagat, S. et al. Nat Genet51,
1369–1379 (2019).
*3 Katayama, S. & Panelius, J. et al. J. Invest. Dermatol.139, 2058–2061.e4
(2019).
*4 Katayama, S. & Hammar, KS. et al. Eur. Respir. J.55,
1901330 (2020).
*5 Katayama, S. et al. J. Bioinformatics29, 2943–2945
(2013).
*6 Krjutškov, K. & Katayama, S. et al. Hum. Reprod.31,
844–853 (2016).
*7 Katayama, S. et al. BMC Bioinformatics20, 418–9 (2019).
Research Associate/PostDoc/Sr.
Res. Associate positions are available immediately in the Department of
Anesthesiology at the University of Miami Miller Medical School. The
research focuses on the mechanisms of neuropathic
pain and opioid abuse with gene therapy supported by the NIH funded
projects. The positions open to recent PhD and/or MD with background in
molecular biology, histology/imaging, or a related discipline.
Priority to applicants with skills of Animal Surgery of nervous system/pain-related Behavioral Testing/Neuropharmacology, or
Genomic/Epigenetic, Exosome, luciferase assay, ChIP-seq, RNA-seq, gene cloning, DNA damage and repair etc. is given.
Applicants with Master degree and strong background related to this research skill are also available. The title may be changed based on experience. Please send your CV to:
Dr. Hao, Department of Anesthesiology, University of Miami Miller Medical School, Miami, FL 33136. shao@med.miami.edu
Suomen Solubiologit ry piti vuosikokouksensa torstaina 13.2.2020 Biomedicumissa, Helsingissä ennen Suomen Sidekudostutkijat ry:n kanssa järjestettyä yhteisseminaaria.
Yhdistys sai kokouksessaan uuden hallituksen vuodelle 2020:
Elina Siljamäki (Puheenjohtaja)
Jan Koski (Varapuheenjohtaja)
Johanna Matilainen (Tiedotussihteeri)
Kai Härkönen (Rahastonhoitaja)
Linda Kauppinen (Hallituksen jäsen)
Terhi Heino (Hallituksen jäsen)
Jenni Tuominen (Hallituksen jäsen)
Emilia Kettunen (Hallituksen jäsen)
Niko Kangasniemi (Hallituksen jäsen)
Haluamme vielä kerran kiittää Anne-Mari Koivistoa ja Eveliina Korhosta kuluneista hallitusvuosista sekä toivottaa tervetulleiksi uudet hallituksemme jäsenet, Kai Härkösen ja Terhi Heinon!
We had a great seminar of the Finnish Society for Cell Biology and Connective Tissue Society (from now on The Finnish Society for Matrix Biology) in Biomedicum, Helsinki on Thursday 13th. The Finnish Society for Cell Biology wants to thank all the speakers, participants and organizers for an amazing day!
The Joint Meeting of the Finnish Connective Tissue and Cell Biology SocietiesJarkko Koivunen and Elina Siljamäki opening the joint meeting of Finnish Connective Tissue Society and The Finnish Society for Cell BiologySylvie Ricard-Blum starting the first session Johanna Ivaska (University of Turku): Adhesion regulated mechanotransduction in cancer
Eija Jokitalo from the University of Helsinki
giving a lecture about endoplasmic reticulum structure, dynamics and functionSponsor talk by Lauri Paasonen (UPM biofore)Coffee break before the second session! Janine Erler from the University of Copenhagen
starts the second session by asking ”How cancer builds its home”Sara Wickström
from the University of Helsinki discussing mechanical forces and the nucleusAleksi Isomursu from the Ivaska Lab, University of Turku
Sanna Pasonen-Seppänen from the Institute of Biomedicine, University of Eastern Finland giving a talk about hyaluronan in tumor-stroma interaction Diana Toivola from Åbo Akademi and University of Turku: Colonic epithelial cell intermediate filaments protect from colitis and colorectal cancer Artemis Filippou from the University of Helsinki describing how the inhibition of anoctomin 1 induces apoptosis via downregulation of mcl-1 in head and neck squamous cell carcinomaValerio Izzi’s (University of Oulu) presentation about cancer matrisome and microenvironment finishes our awesome seminarScientific discussions continuing at dinner. Thank you all for participating our seminar!
Vuoden 2019 toisessa numerossa on mukana Jukka Westermarckin (syöpätutkija, lääkäri, syöpäbiologian professori ja tutkimusjohtaja, Turun yliopisto) haastattelu, kuukauden solubiologi Johanna Tuomela (solubiologian dosentti, ryhmänjohtaja, yliopistonlehtori, Turun yliopisto), Anu Kauppisen immuno-oftamologian tutkimusryhmän esittely (Itä-Suomen yliopisto), Mari Björkmanin ”Solubiologina lääketeollisuudessa” kolumni sekä asiaa seeprakalasta ja jobitista!
Krefting
Research Centre, Institute of Medicine, University of Gothenburg, is
recruiting a post-doctoral researcher for a 2-year contract. Krefting
Research Centre (http://krefting.gu.se)
is a centre funded by the VBG Group Herman
Krefting Foundation for Asthma and Allergy Research. The main research
at the Krefting Research Center focuses on asthma and allergies, and
includes basic inflammation research, clinical
studies and population-based studies. The basis for the research is the
ongoing ”West Sweden Asthma Study”, one of Europe’s largest
population-based studies of asthma that was started in 2008 in Västra
Götaland.
To
qualify as a postdoctoral researcher the applicant should hold a PhD in
a relevant subject. Since postdoctoral constitutes a qualifying
appointment for junior researchers,
we aim to target those who have a doctoral degree not older than 3 years
from the application deadline.
Haemme genetiikan tuotespesialistia Turun, Helsingin tai Tampereen toimipisteeseemme.
Pääasiallisena työtehtävänäsi on laajentuvan genetiikan ja onkologian
valikoimamme tuotteiden myynti, markkinointi ja tuotetuki koko Suomen
alueella, sekä Baltian myyntiorganisaation tukeminen. Asiakaskuntaasi
ovat mm. yliopisto- ja keskussairaaloiden laboratoriot ja osastot,
yksityisen terveydenhuollon palveluntarjoajat sekä yliopistot ja
tutkimuslaitokset. Lisäksi sinulla on työssäsi merkittävä rooli
tuotevalikoimamme sekä asiakassuhteidemme kehittämisessä ja
vahvistamisessa yhteistyössä muun organisaatiomme kanssa.
Odotamme sinulta työtehtäviin soveltuvaa koulutusta (humaani- tai
syöpägenetiikan alan korkeakoulututkinto tai vastaava) ja/tai kokemusta
vastaavista työtehtävistä sekä erityisesti intoa ja halukkuutta
asiakaslähtöiseen kenttätyöhön. Kokemus kliinisen genetiikan
laboratoriossa työskentelystä ja NGS-teknologian käytöstä katsotaan
eduksi. Sinulla on hyvä suomen ja englannin kielen suullinen ja
kirjallinen taito, ruotsin kielen taito on plussaa. Ajokortinkin
tarvitset. Olet valmis matkustamaan kotimaassa ja Baltiassa viikoittain.
Tarjoamme myyntihenkisellä asenteella varustetulle avoimelle ja
sosiaaliselle osaajalle mielenkiintoisen ja haastavan työn reilussa ja
mutkattomassa, töitä tosissaan tekevässä organisaatiossa sekä
kilpailukykyisen palkkauksen ja työsuhde-edut. Tehtävä on määräaikainen
äitiysloman sijaisuus, ja paikka täytetään heti sopivan henkilön
löydyttyä.
Lähetä hakemuksesi, ansioluettelosi ja palkkatoiveesi sähköpostitse 23.2.2020 mennessä osoitteeseen rekry@triolab.fi. Älä suotta aikaile, sillä alamme käydä hakemuksia läpi sitä mukaa, kun niitä tulee.
Lisätietoja antaa Triolab Oy:n myynti- ja markkinointijohtaja Jussi
Kurittu (p. 0400 800 917) – tavoitettavissa varmimmin ti 11.2. ja pe
14.2. klo 13-15.
Triolab Oy on vuonna 1986 perustettu korkealaatuisten
diagnostiikka- ja tutkimustuotteiden myyntiin, tuotetukeen ja huoltoon
erikoistunut asiantuntijayritys. Meillä työskentelee yli 40 alan
ammattilaista. Triolabin pääkonttori ja varasto sijaitsevat Turussa. Sen
lisäksi meillä on aluetoimistot Helsingissä ja Tampereella. Yrityksemme
kuuluu 600 ammattilaisen pörssinoteerattuun AddLife-konserniin, jonka
päämarkkina-alue on Pohjoismaat.
An enthusiastic and goal-oriented technical assistant is sought to
the Extracellular Vesicle group of Pia Siljander in the Molecular and
Integrative Biosciences research program, University of Helsinki,
located in Viikki. Part of the project may also be carried out in the
Institute of Molecular Medicine Finland, Helsinki. Our laboratory, which
also hosts a dedicated EV Core facility, specializes in cutting-edge EV
technologies and research.
Projects and responsibilities
We
have two ongoing interlinked projects funded by Business Finland where
we need technical assistance for the development of EV isolation and
analytical technologies and standardization. The laboratory work in
project one involves testing of a new technology to carry out
high-throughput isolations of EVs from plasma by testing different
conditions, plate formats and automatization in comparison to existing
methods. The quality of the isolates will be evaluated by EV
methodologies (including flow cytometry), through omics testing and
usual molecular biology methods. The work also involves analysis of EV
samples originating in the second project by the technologies available
in the EV group and core and through the other project participants.
This project also develops standardization for flow cytometry and
materials for standardization.
Qualifications
A
successful candidate has good skills in the essential molecular biology,
cell culture and biochemistry techniques, e.g. Western blotting and
working with multi-well assays. We value prior experience in flow
cytometry, data management and data analysis. The successful candidate
has an active approach to addressing lab needs, keeps meticulous records
of the experimentation and is a dedicated team player with excellent
self-management skills.
Salary, applications and contact information
Position
will be available 10.2.-31.12.2020. The start date can be set according
to agreement, but preference will be given to candidates who can start
as early as possible. Salary will be based on the University salary
scheme depending on the degree/work experience.
Position will be filled as soon as a suitable candidate is found.
Applications
should have a cover letter describing the qualifications of the
candidate, CV and two references from past employment and be sent to
maija.puhka@helsinki.fi and pia.siljander@helsinki.fi.
The
projects focus on studying stem / progenitor cell biology developing
kidney and aim to understand causes of congenital renal malformations in
humans.
Our group studies renal development with the help of different genetically modified mouse models and different in vitro culture
systems. We are specifically interested in understanding how kidney
growth through
ureteric bud branching morphogenesis is regulated and which kind of
cellular events drive its complex pattern. Our projects also explore how
growth factor induced signaling controls nephron progenitors during
their self-renewal and differentiation into the
functional units of the kidneys, the nephrons.
All applicants with genuine
interest in developmental and stem cell biology are encouraged to submit
a motivation letter, CV and possibly reference letter (if applicable)
to satu.kuure(at)helsinki.fi
before the deadline on February 28, 2020.
For further information, see Kuure lab or contact the group leader Satu Kuure (satu.kuure(at)helsinki.fi
, +358 2941 59395).
Selected publications:
Takko, H., Pajanoja, C.,
Kurtzeborn, K, Hsin, J., Kuure, S. and Kerosuo, L. ShapeMetrics: a
userfriendly pipeline for 3D cell segmentation and spatial tissue
analysis Dev. Biol., Conditionally accepted.
Kuure, S. Sariola, H. Mouse
models of congenital kidney anomalies. Chapter 5 in book Animal models
of human birth defects, Springer Nature Singapore Pte Ltd. In press.
Dapkunas A, Rantanen V, Gui
Y, Lalowski M, Sainio K, Kuure S, Sariola H. Simple 3D culture of
dissociated kidney mesenchyme mimics nephron progenitor niche and
facilitates nephrogenesis Wnt-independently. Sci Rep.
2019 9(1):13433.
Kurtzeborn, K., Kwon, H.N., Kuure, S. 2019. MAPK/ERK signaling in regulation of renal differentiation. Int J Mol Sci. 2019 20(7).
Li, H., Jakobson, M., Ola, R., Gui, Y., Kumar, A., Sipilä, P., Sariola, H., Kuure, S*. Andressoo, J-O*. 2019. Development of the urogenital system is regulated via the 3’UTR of
GDNF. Sci Rep, 9(1):5302.
Zhang, H., Bagherie-Lachidan,
M., Badouel, C., Enderle, L., Peidis, P., Bremner, R., Kuure, S., Jain,
S., McNeill, H. 2019. FAT4 fine-tunes kidney development by regulating
RET signaling. Dev Cell, 48(6):780-792.e4.
Ihermann-Hella,
A., Hirashima, T., Kupari, J., Kurtzeborn, K., Li, H., Kwon, H.N.,
Cebrian, C., Soofi, A., Dapkunas, A., Miinalainen, I., Dressler, G.R.,
Matsuda, M., Kuure,
S. 2018. Dynamic MAPK/ERK Activity Sustains Nephron Progenitors through
Niche Regulation and Primes Precursors for Differentiation. Stem Cell Reports, 11(4):912-928.
