Ajankohtaista

Postdoc position in the laboratory of Dr. Brady Atwood in the Department of Psychiatry at Indiana University School of Medicine

The laboratory of Dr. Brady Atwood in the Department of Psychiatry at Indiana University School of Medicine is seeking to fill an immediate opening for a full-time post-doctoral appointee.

Candidates should possess a doctoral degree in neuroscience, pharmacology, physiology or a related field. The postdoc will have opportunities to learn patch clamp electrophysiology, in vitro and in vivo optogenetics and animal behavior paradigms.  

Research space will be in the new Neurosciences Building; investigators in this building have access to state-of-the-art Core Facilities. The department and the university place a high priority on creating a diverse learning environment and on supporting the professional development of ethnic minorities, women, veterans, and people with disabilities. Applications are encouraged from professionals of all ethnic backgrounds.

Please email Dr. Brady Atwood at bkatwood@iu.edu for further information. If interested, please email your CV and the contact information for at least 3 references. ​

Open position for a Senior Scientist (diagnostics and immuno assay development) in Biopromic AB, Solna, Sweden

Make a real difference in the fight against infectious diseases. Biopromic AB (http://biopromic.com/ ) strive to develop Point of care testes for rapid diagnosis of infectious diseases. Our portfolio covers several important know-how and technologies for the development of different test platforms of importance in the fields of human and veterinary diagnostics.

Duties and responsibilities:

–        Responsible for the methodologies and make sure recipes are available.

–        Preparation of project-and validation documents and reports.

–        Expertise in immunoassays development (ELISA, Lateral flow and other), and provide technical support to the rest of the team.

–        Actively involved in troubleshooting in R&D daily work.

Requirements and qualifications:

–        PhD in Biomedical Science or equivalent.

–        At least 4 years experience as a scientist i a field of diagnostic research and development.

–        Experience in biochemistry, cell culturing, chromatography, assay development and validation and immunoassays.

–        Excellent command of the English language in both verbal and written,

–        Experience in development of monoclonal antibodies – from cell culture to purification and QC

–        Accountable: Prioritize your work and take responsibility for your own tasks and supporting others in the team.

–        Experience of work according to GMP is a merit.

–        Accurate and meticulous in daily work and delivering according to plan.

We look forward to reading your application with full CV!

Location: Solna/Stockholm, Sweden

Application deadline: 2019-05-15

Submit your application to: careers@biopromic.com  using a code SS2019 in the title of your email.

For more information contact us at: careers@biopromic.com

Postdoc position at Welcome-Wolfson Institute for Experimental Medicine, Queen´s University, Belfast

FULLY FUNDED 2-YEAR POSTDOCTORAL POSITION IN THE VALVANO GROUP

A Postdoctoral Fellow position for an individual with training and demonstrated abilities in cell biology/cellular immunology/cellular microbiology is available in the Valvano group to investigate the inflammasome in human CFTR-defective macrophages and monocytes.

Project summary: Infection and chronic inflammation in patients with cystic fibrosis (CF) lead to progressive lung damage. CF-defective macrophages fail to kill engulfed opportunistic pathogens such as Burkholderia cenocepacia. Engulfed pathogens disarm macrophages and counteract immunity by deploying proteins (effectors) that alter central cellular pathways including actin cytoskeleton remodeling. Pathogen-induced disorganization of the actin cytoskeleton is both a remarkable anti-host strategy and a danger signal driving inflammation and cell death. However, the actin cytoskeleton dynamics in the context of the CF defect has not been explored. We hypothesize that intracellular opportunistic pathogens engulfed by macrophages, in combination with the CF genetic defect, induce disorganization of the actin cytoskeleton that leads to a

highly proinflammatory state. Our research established B. cenocepacia as a model organism for cellular microbiology. We discovered that a B. cenocepacia type VI-secretion system (T6SS) disrupts the macrophage’s actin cytoskeleton and elicits pyroptosis (proinflammatory cell death), and we recently identified TecA as the T6SS protein responsible for these phenotypes by causing the direct inactivation of Rho GTPases, which in turn activates the Pyrin inflammasome and the ASC complex formation. We will

investigate here the relationship between inflammation and B. cenocepacia-mediated modulation of macrophages’ actin cytoskeleton in CFTR-defective human monocytic macrophages. We will address 2 specific aims: (1) To assess the status of the pyrin inflammasome in B. cenocepacia-infected, CFTRdefective peripheral monocytes; and (2) To evaluate the role of the B. cenocepacia T4SS and T2SS systems in the activation of ASC-dependent inflammasomes upon infection in human macrophages.

Interested applicants should contact Prof. Miguel A. Valvano at m.valvano@qub.ac.uk and provide a CV, brief statement of interest, and references.

Open position for an Assistant/Associate Professor / Professor, Emerging Infectious Diseases, HOH Helsinki One Health

The University of Helsinki is an international scientific community of 40,000 students and researchers. It is one of the leading multidisciplinary research universities in Europe and ranks among the top 100 international universities in the world.

HOH Helsinki One Health is a new network organization, led by the Faculty of Veterinary Medicine and cooperated by four other faculties at the University of Helsinki, to co-ordinate research actions within the area of One Health. One Health is a globally emerging concept recognizing that the health of humans and animals is interconnected and that their populations share the essentials of life: the genome, disease causing organisms, health, welfare, and the environment. HOH Helsinki One Health involves different disciplines and professions to work together to resolve emerging health problems concerning human and animal populations worldwide. In addition to other profiling actions, HOH Helsinki One Health will host several tenure track professorships with their established research environments in years 2018-2022. Please see: https://www.helsinki.fi/en/one-health.

We invite applications for the position of an

ASSISTANT PROFESSOR / ASSOCIATE PROFESSOR / PROFESSOR IN EMERGING INFECTIOUS DISEASES

This is a joint position between the Faculty of Medicine and the Faculty of Veterinary Medicine. The research and teaching field of the professorship is microbiology, infectious diseases and vaccines.

More information and application at https://www.helsinki.fi/en/open-positions/assistant-professor-associate-professor-professor-in-emerging-infectious-diseases-hoh-helsinki-one-health

Deadline for applications is May 26, 2019.

Blueprint Genetics is looking for a Geneticist (Clinical Interpretation, Helsinki)

Introduction
Blueprint Genetics is on a mission to bring world-class genetic knowledge to mainstream healthcare. To meet the challenges imposed by our rapid growth, we are looking for new Geneticists to join our Clinical Interpretation Team. We are a team of experienced professionals with diverse backgrounds who share the passion for helping patients and families suffering from inherited disorders. Our constantly evolving diagnostic portfolio currently includes over 200 tests that cover a wide variety of clinical specialties and diagnostic approaches, including Whole Exome Sequencing. We work with hundreds of clinics around the globe and the quality of our interpretation has been praised by many of the world’s best medical centers. If you have the ambition to be among the pioneers of the molecular era of medicine, you might be the person we are looking for.

Job description
The position involves interpretation and reporting of findings from our clinical molecular genetic tests, including panel-based tests, Whole Exome Sequencing and targeted variant tests. Our Geneticists also participate in the development and validation of products and applications in a project team environment. Those interested get to collaborate with our Software Engineers and Data Scientists with the development of our proprietary software tools that enable us to interpret identified variants efficiently by utilizing artificial intelligence and machine learning.

The ideal candidate has:

• Clinical Laboratory Geneticist degree or Board certification in Clinical Molecular Genetics / Laboratory Genetics and Genomics or Ph.D. in Genetics.
• Experience in interpreting and reporting genetic test results in a clinical setting utilizing NGS, Sanger sequencing and other methods is an asset, but similar research experience is valued as well.
• Knowledge of current genomic information and variant databases is essential
• Fluent skills in oral and written English are a necessity
• Great attention to detail
• Critical thinking when reviewing scientific literature
• Effective planning and organization skills
• Excellent follow-through abilities
• Experience in working under certified and accredited quality management systems is an asset.
• Fitting the immediate, low-hierarchy and positive Blueprint culture

What we offer
At Blueprint Genetics, you get to be a valued part of our global and multidisciplinary team of people who want to make a difference. You will be working daily to bring your expertise from base pairs to bedside for improved patient outcomes. We offer you a rapidly evolving working environment where you can learn and grow together with a unique company and great colleagues. You get to use everything you have learned in an environment that is unlike anything you have experienced before.

The position is permanent full-time position.

More information and application at https://careers.blueprintgenetics.com/jobs/212558-geneticist

Research programs unit at the University of Helsnki has an open position for a BIOINFORMATICIAN in an exciting collaboration discovering pathways and targets for neurodegenerative diseases

The Faculty of Medicine promotes scientific research of a high standard and is responsible for providing research-based undergraduate and postgraduate education in medicine, dentistry, psychology and logopedics, as well as for the English-language Master’s Programme in Translational Medicine. In addition to its teaching and research activities, the Faculty serves as a significant expert organisation in the healthcare sector and contributes to the discourse on ethics in the field. In terms of research, the Faculty aims for a place among the best medical faculties in the world, while consolidating and strengthening its status as a top-level institution of medical education.

Together with the Helsinki University Hospital (HUS) and the Helsinki Institute of Life Sciences (HiLIFE), the Faculty of Medicine, University of Helsinki, constitutes the Academic Medical Center Helsinki (AMCH). This medical center has been very successful in international comparisons, ranking among the top 10 medical campuses in Europe and among the top 50 globally.

Research Programs Unit of the Faculty of Medicine is a top-quality research environment. Unit’s nine research programs comprises groups that integrate clinical, translational and biomedical research.

Research programs unit has an open position for a BIOINFORMATICIAN  in an exciting collaboration discovering pathways and targets for neurodegenerative diseases. We search for an experienced bioinformatician highly motivated to participate in an early-discovery NeurOmics project, belonging to a novel pharma-academia “New Modalities Ecosystem”.

More information and application at https://www.helsinki.fi/en/open-positions/bioinformatician

A post-doctoral fellow in Thyroid Research at the Institute of Biomedicine, University of Turku, Turku, Finland

Post-doctoral job is available at the Research Centre for Integrative Physiology and Pharmacology, In Docent Jukka Kero´s Thyroid group at the Institute of Biomedicine, University of Turku, Finland. The Department is well equipped with facilities for modern molecular and cell biology research. The close connection with Turku Center for Disease Modeling (TCDM) offers excellent facilities and infrastructure to perform experiments with genetically modified disease models.

We are looking for a highly motivated senior researcher or a postdoc with strong experience in molecular biology, genetics and experimental disease models. The group focuses on molecular mechanisms of thyroid disorders. We are studying thyroid genetics in patients with congenital or hereditary thyroid diseases using in silico, in vitro methods, or genetically modified disease models.

The research project focuses on novel gene mutations and testing their pathogenicity in vitro and in vivo. The work involves analyzing the next-generation sequencing data and generation and phenotyping of new disease models. The researcher will work closely with technicians and PhD-students in the group.

There is a trial period of four (4) months. The position is for 2-4 years and could start in May 2019 or as negotiated.

For more information, please contact Jukka.Kero@utu.fi .

Post-doctoral position in the group of Inari Kursula at the Faculty of Biochemistry and Molecular Medicine & Biocenter Oulu, University of Oulu, Finland

We have an opening for an enthusiastic post-doctoral fellow to study the molecular mechanisms governing actin polymerization, ATP hydrolysis, phosphate release, and filament stability in malaria parasite actins. The successful candidate has a keen interest to understand cytoskeletal proteins and cell motility in depth. A strong background in protein biochemistry and X-ray crystallography is required. Expertise in cryo-EM sample preparation and structure determination will be highly valued. In addition, a high level of own initiative and the ability to work in a team and supervise younger scientists are necessary.

The Faculty of Biochemistry and Molecular Medicine (FBMM; https://www.oulu.fi/fbmm/) is a dynamic and international working place, where the working language is English. Protein science is one of the focal areas of the Faculty. FBMM provides cutting-edge research facilities for molecular biology, protein biochemistry, X-ray crystallography, and light and electron microscopy. In addition, we have generous access to several large-scale facilities for structural biology (MX/SAXS/cryo-EM).

Funding is initially available for 2.5 years, but there may be possibilities for an extension. The starting date should be as soon as possible.

Applications and informal enquiries should be sent by e-mail to inari.kursula@oulu.fi.

Applications should contain

(i)                  a cover letter detailing your specific interest in this project and your key skills and expertise,

(ii)                a CV including a list of publications, and

(iii)             contact information (e-mail) for 3 referees.

Applications should preferably be sent by 30.4.2019, but screening of candidates will continue until a suitable one has been identified.

For more information on our work, please visit our website: http://cc.oulu.fi/~inkursul/lab

Some recent publications directly relevant for the topic:

Kumpula EP, Lopez AJ, Tajedin L, Han H & Kursula I (2018) Atomic view into Plasmodium actin polymerization, ATP hydrolysis, and phosphate release. bioRxiv: 467423, https://doi.org/10.1101/467423.

Kumpula EP, Pires IP, Lasiwa D, Piirainen H, Bergmann U, Vahokoski J & Kursula I (2017) Apicomplexan actin polymerization depends on nucleation. Sci Rep 7: 12137.

Pospich S, Kumpula EP, von der Ecken J, Vahokoski J, Kursula I & Raunser S (2017) Near-atomic structure of jasplakinolide-stabilized malaria parasite F-actin reveals the structural basis of filament instability. Proc Natl Acad Sci 114: 10636-10641.

Green JL, Wall RJ, Vahokoski J, Yusuf NA, Ridzuan MAM, Stanway RR, Stock J, Knuepfer E, Brady D, Martin SR, Howell SA, Pires IP, Moon RW, Molloy JE, Kursula I, Tewari R & Holder AA (2017) Compositional and expression analyses of the glideosome during the Plasmodium life cycle reveal an additional myosin light chain required for maximum motility. J Biol Chem 292: 17857-17875.

For a full list of publications from our group, see: http://cc.oulu.fi/~inkursul/lab/Molecular_mechanisms_of_actin-based_motility/publications.html 

Post-doc position at the University of Pennsylvania / development & regeneration

Postdoctoral position in skin appendage development and regeneration – Departments of Genetics and Dermatology, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA USA

The Kamberov lab is seeking a candidate to fill a post-doctoral position in skin appendage development and regeneration. The relevant project will focus on investigating the signaling networks that control mammary and sweat gland development, functionality and evolutionary variation. A major goal of this project is to regenerate these organs in vitro. Experimental approaches to be used include generation, analysis and validation of large-scale transcriptomic data from the skin, functional testing and modeling in mice and in vitro organoid culture. The position provides an exciting opportunity to work at the interface of basic and translational research in a highly collaborative environment and gain experience in approaches at the cutting edge of developmental and regenerative biology.

Interested applicants should send a CV, contact information of three references and a letter detailing your interest in the position and lab to Yana Kamberov (yana2@pennmedicine.upenn.edu). Applicants should hold a Ph.D. in biology or related field. Applicants with a strong background in molecular biology, mouse genetics, developmental biology and/or bioinformatics are encouraged to apply.

https://www.kamberovlab.com/

Postdoctoral Researcher (Bioinformatics / Neurosciences), University of Eastern Finland

The University of Eastern Finland, Faculty of Health Sciences, A.I. Virtanen Institute of Molecular Sciences, invites applications for a Postdoctoral Researcher (Bioinformatics / Neurosciences).

The Kanninen research group is seeking a motivated and experienced postdoctoral researcher to join a highly dynamic group of neuroscientists working on Alzheimer’s disease. The group utilizes in vitro cultures of brain cells to investigate molecular and cellular mechanisms of neurodegeneration. More details on research interests can be found at https://www.uef.fi/en/web/aivi/katja-kanninen-group
 

In this position the candidate should have a PhD in computer science, bioinformatics, biostatistics, neuroscience or related discipline. Experience with various statistical methods is required and the successful candidate should be proficient in using the R programming language. The candidate should be committed and motivated, display independent thinking skills, and possess the ability to work independently while supervising students. Good knowledge of written and spoken English are essential.

The application deadline is 16/04/2019 and the position is filled for a fixed term from 1st of May in 2019 (or as agreed) to 30th of April in 2020. The position is filled for a fixed term due to the duration of the project.  More details at https://www.uef.fi/en/web/guest/uef/en-open-positions

For further information on the position, please contact: Group Leader, PhD, Associate Professor (tenure track), Academy Researcher Katja Kanninen, +358 29 4454202,katja.kanninen@uef.fi. 

For further information on the application procedure, please contact HR Secretary Asta Suhonen, tel. +358 29 4454125, asta.suhonen@uef.fi.