Job description
The Department of Cell and Molecular Biology (CMB) is a department
with a strong focus on basic science. CMB conducts research and
education in cell biology, molecular biology, developmental biology,
stem cell biology, cancer and infection biology.
Division The research group of Johan Holmberg is
part of the Department of Cell and Molecular Biology (CMB) which
recently moved to the new interdisciplinary research centre Biomedicum
located at Campus Solna, Karolinska Institutet.
Background The brain contains a large number of
different neuronal subtypes that maintain their distinct identities over
several decades despite continuous environmental fluctuation. Apart
from the instructive information provided by transcription factors
controlling cell type specific transcriptional programs, there is
presumably also a need to maintain silencing of alternative
transcriptional programs. The mechanisms governing permanent repression
of aberrant transcription in mature neurons are not well understood. Our
lab focuses on the role of repression of alternative gene programs for
lifelong maintenance of serotonergic and dopaminergic identity. For a
more extensive background see: Holmberg and Perlmann, Nature Review Genetics2012and Södersten, E. et al. Nature Commun. 2018.
Besides exploring fundamental processes we also aim to understand how
they influence clinically relevant topics including psychiatric
disorders, neurodegeneration and aging. The group also harbour an
interest in the understanding of the paediatric malignancy,
neuroblastoma, see: Westerlund, et al. Proc Natl Acad Sci U S A 2017.
In this project we will generate and analyse large amounts of data
from defined wild type/mutant mouse neuronal populations in order to
understand the functional relevance of gene repression for safeguarding
mature serotonergic and dopaminergic identity.
Position specific requirements We are looking for
an outstanding researcher able to analyse and integrate large sets of
bulk and single cell RNA-seq with ChIP-seq data generated from
restricted in vivo neuronal subpopulations. Additional
experience with confocal image acquisition and analysis as well as with
in vivo/in vitro standard methods (e.g. immunostaining, FACS,
stereotactic injections, behavioural analysis and cell culture) will be
considered as a distinct advantage. Thus we are primarily looking for a
computational biologist with experience/interest in laboratory/animal
work or an experimental biologist with extensive bioinformatic skill and
interest.
The applicant must be able to communicate well in English.
Scholarships for postdoctoral qualification can be established for
foreign researchers who place their qualifications in Sweden. The
purpose of scholarships for postdoctoral qualification is to promote
internationalization and contribute to research qualification after a
doctorate or equivalent. A scholarship for carrying out postdoctoral
research can be granted for a maximum of two years within a four year
period following the receipt of a doctoral degree or equivalent. To
be eligible for a postdoctoral scholarship, the person must have
obtained a doctorate or a foreign degree deemed to be equivalent to a
doctorate.
The head of the department determines whether their previous training
and scholarly qualifications correspond to a Swedish doctorate or
higher.
Type of scholarship The amount is tax free and it
is set for twelve months at a time, paid out on a six months basis. In
exceptional cases, shorter periods may be acceptable.
Application process An application must contain the following documents in English or Swedish:
A complete curriculum vitae, including date of the thesis
defence, title of the thesis, previous academic positions, academic
title, current position, academic distinctions, and committee work
A complete list of publications
Cover letter stating the motivation to apply and key skills that match the profile
The application is to be submitted on the Varbi recruitment system.
Karolinska Institutet is one of the world’s leading medical
universities. Its vision is to significantly contribute to the
improvement of human health. Karolinska Institutet accounts for the
single largest share of all academic medical research conducted in
Sweden and offers the country’s broadest range of education in medicine
and health sciences. The Nobel Assembly at Karolinska Institutet selects
the Nobel laureates in Physiology or Medicine. Pursuant to the
regulations of the Swedish National Archives, applications are kept on
file for two years after the appointment has gained legal force. The
regulations do not apply to attachments that have been printed or
otherwise published. Karolinska Institutet strives to provide a
workplace that has approximately the same number of women and men, is
free of discrimination and offers equal opportunity to everyone. For
temp agencies and recruiters, and to salespersons: We politely, yet
firmly, decline direct contact with temp agencies and recruiters, as
well as those selling additional job announcements.
Reference number
2-2626/2019
Contact
Johan Holmberg, johan.holmberg@ki.se
Published
30.Apr.2019
Last application date
30.June.2019 11:59 PM CET
The University of Oulu (http://www.oulu.fi/english/)
is one of the largest universities in Finland, with approximately 15 000
students and 3 000 employees. The University of Oulu Graduate School
(UniOGS) (http://www.oulu.fi/uniogs/)
provides the framework and conditions for high-quality, research-driven
doctoral education at the University of Oulu, and field-specific
doctoral training is provided by its multidisciplinary doctoral
programmes.
Biocenter Oulu (BCO) (http://www.oulu.fi/biocenter/)
offers a high-level international multidisciplinary environment supplied
with cutting-edge infrastructures. Under this framework, the Health and
Biosciences Doctoral Programme (HBS-DP) (http://www.oulu.fi/uniogs/dp/hbsdp)
offers doctoral training in clinical medicine, biomedicine,
biochemistry, molecular medicine, dentistry, health sciences, and
medical technology.
Subject field and the description of the position
Applications are invited for a full-time PhD student position for a maximum of four years, starting on January 1st 2020, in a Biocenter Oulu research project headed by Professor
Petri Kursula in the Biomedical Structural Biology research unit, Faculty of Biochemistry and Molecular Medicine.
Our
main focus is the structural biology of the myelin sheath. Most myelin
proteins are either integral or peripheral membrane proteins, often
involved in either autoimmune or inherited
demyelinating disease. We also have a keen interest in other structural
biology problems, including protein-membrane interactions at the
molecular level, high-resolution crystallography, and the structural
basis of various neurological diseases. More details
can be found at https://www.uib.no/en/rg/petrikursula.
The
position is supervised by Prof. Petri Kursula and Dr. Salla Ruskamo and
is focused on the 3D molecular and atomic structure of the myelin
sheath, as well as the molecular mechanisms
of mutations causing human hereditary neuropathies.
Required Qualifications and assessment
To
successfully occupy the PhD student position, the candidate must
possess an MSc degree in biochemistry, biophysics, protein science, or
another relevant field. Practical experience
in protein research will be highly valued, and a keen interest in
biophysics and structural biology are required. The MSc degree must have
been completed with good grades by December 2019, preferably by the
call deadline. Ability to pursue independent research
as a member of a team and excellent oral and written communication
skills in English are expected.
The
position is intended for an Early Stage Researcher (ESR) who, according
to the ”European Charter for Researchers and the Code of Conduct for
the Recruitment of Researchers”, is defined
as a researcher in the first four years (full-time equivalent) of
his/her research activity, including the period of research training.
Applicants will be either starting their doctoral training, or will have
completed no more than two full years of training
(adjusted for possible previous part-time status) at the time the
position is filled. The selected candidate will carry out his/her
doctoral studies in the HBS-DP of the UniOGS and must meet the minimal
requirements to receive doctoral study rights as defined
in http://www.oulu.fi/uniogs/requirements_for_admission.
Salary
The
salary of the selected doctoral student will be initially set on level
2, and later on levels 2 – 4, of the national salary scale for the
teaching and research staff of Finnish
universities. In addition, a supplementary remuneration is given for
personal achievement and performance (max. 50 %). In practice, the
salary is roughly 2200 – 2700 € per month for an early stage researcher,
depending on qualifications and progress of the
doctoral thesis.
Since
this call is for a starting PhD student, the position will be filled
for a four-year period, beginning on 1 January 2020. A six-month trial
period will be applied in the position.
The following documents must be attached to the application (in English)
Complete CV containing the contact information of 2-3 sources for references (Max. size
of the attachment: 5 Mbytes)
Motivation letter (maximum 1 page) describing prior experience, research interests, and
career plans (1-2 pages; max. size of the attachment: 2 Mbytes).
Certificates/Diplomas:
Scanned electronic copies of diplomas and transcripts of the records
of relevant previous degrees. If the original documents are not in
English, Finnish, or Swedish, each document must be accompanied by an
official certified translation into English or Finnish. (Max. size of the attachment: 2 Mbytes)
Other relevant information
Eligible
applicants fitting best in the expected research profile will be
invited to an on-site or remote interview. All applicants will be
notified when the selection process
is completed.
Contact
Prof. Petri Kursula, e-mail: petri.kursula(at)oulu.fi
The University of Oulu is one of the largest universities in Finland. With about 14 000 students and approximately 3 000 employees it is a vibrant international scientific community. By combining multidisciplinary research and education, high-level infrastructure and wide cooperation with international research and educational institutes, companies and the public sector it has created a significant research and innovation hub of “Science with Arctic Attitude”. More information http://www.oulu.fi/university/.The position is located in the Faculty of Biochemistry and Molecular Medicine of the University of Oulu (http://www.oulu.fi/fbmm/), whose mission is to perform internationally significant research and to deliver high-level undergraduate and post-graduate education in the fields of biochemistry and molecular medicine. The Faculty’s research focus areas are cell-extracellular matrix, protein science and cellular regulatory and metabolic networks and related diseases. The research lines are carried out by 14 research groups. The Faculty has collectively about 200 employees and about half of them are from abroad.
Subject field and the description of the position
The FET open project MindGAP is aiming to characterize CNS originating Extracellular Vesicles from the blood of cancer patients undergoing therapy. The project involves EV isolation from biofluids and primary human cell culture, Characterization of EV surface molecule, RNA analysis (ddPCR and Next Generation Sequencing) and collaboration with other members of the consortium, in Portugal and Oulu. We are looking for a candidate with strong molecular and cellular biology background and interest for Extracellular Vesicles. Experience with liquid biopsy, Extracellular Vesicles RNA/ DNA, surface protein isolation, bioinformatics/ neurobiology is an advantage.
The duration of the position is from September 1st 2019, or as soon as possible thereafter, ending in March 31st 2023.Required Qualifications and assessment
The successful applicant must hold an MSc degree in life sciences (Biology/ Biochemistry). Candidates whose master thesis will be submitted by the application deadline will also be eligible. Good oral and written English skills, good communication and teamwork skills are required.
A six-month trial period will be effective in the beginning of a contract.
Salary The salary is in accordance with the University salary system (for teaching and research personnel) levels 2-4. In addition, there is a share increase at most, 50% of the base salary, which is based on personal achievements and performance.
Application Procedure The following documents must be attached to the application (in English): 1) Motivation letter 2) CV, including publications and the names and contact details of 2 – 3 referees 3) Copies of relevant official degree
Applications sent by email will not be considered.Interview Most suitable candidates for the post may be interviewed and asked to present their scientific work and experience.
For further information regarding the filling of this post: Dr Seppo Vainio, Professor, e-mail: seppo.vainio(at)oulu.fi Dr Genevieve Bart, Adj. Professor, e-mail: genevieve.bart(at)oulu.fi Tiina Hurskainen, HR Manager, email: tiina.hurskainen(at)oulu.fi
Suomen Solubiologit ry piti hallituksen kokouksensa tänään 6.6.19 Hard Rock Cafessa, Helsingissä. Hyvän ruoan lomassa suunniteltiin muun muassa syksyn työelämäseminaaria, mahtava tapahtuma taas tulossa! Päätimme tehdä myös twitter-tilin, joten käythän seuraamassa meitä myös siellä:
You will be part of a dynamic, international and
multidisciplinary team that develops a completely new medical diagnostic
device to be used at the point of need. As “Process Development Technician”
you will support processing activities related to back-end processing
of the silicon-based nFP. You will generate the necessary data and
knowledge to make the transition from test prototypes to market ready
products. You will also provide the development teams with the necessary
components to support the prototype manufacturing and testing needs.
Responsibilities
You will become part of
a team of scientists and engineers that is developing a new device for
molecular diagnostic testing. In your role of Molecular Biologist, you
will develop and optimize new assay principles for nucleic acid
purification, extraction, amplification and detection on a silicon chip.
In particular, you will:
Develop new methods for nucleic acid extraction within a silicon chip
Develop new methods for nucleic acid amplification and detection
Develop new sample prep methodologies to purify nucleic acids from diverse clinical sample specimens
Design and optimize assays to be run on the silicon chip
Interact
with silicon chip designers and process engineers to match the silicon
chip to the needs of the molecular biology and vice versa
Profile and competences:
You have a MSc or PhD degree in molecular biology, (bio)chemistry engineering or bioscience engineering
Ideally, several years of experience in PCR, assay design and/or other ways of nucleic acid detection technologies
Experience in de novo assay development, not based on existing kits, is a plus
A keen interest in novel technologies for molecular diagnostics
A thorough understanding of chemistries related to nucleic acids and solid phases is a plus
Experience in microfluidics is a strong plus
Hands-on and resourceful problem solver is a must
Attention to detail, works in a structured and methodological way
Bioinformatics and Data Mining, Global Research Technologies
Denmark – Måløv
Do you like working on the intersection between biology and
data, and drive the use of genetics for drug discovery? Then this job
might be right for you. We are looking for a scientist with deep
expertise in using human genetics, experience for drug discovery, strong
leadership skills, and the ability to lead our representation in key
external partnerships and consortia to support our drug discovery
pipeline.
About The Department
The Department of Bioinformatics and Data Mining combines
strong computational skills with biological insights through the
integrative analysis of internal and external biomedical data. Our
analytical expertise spans a wide range of areas, from genetics,
sequence analysis, many different omics, pathway analysis, to
text-mining. We contribute to all aspects of pre-clinical research
projects at Novo Nordisk, where we act as data-driven experts and
participate in external collaborations with academic and biotech
partners. Our work results in real impacts on new medicines for highly
important diseases of unmet medical need.
The position
Your main responsibility will be to work closely with our
scientists in Global Research to drive the application of human genetics
in drug discovery to positively impact the success of our R&D
pipeline. As such you will have extensive expertise in human genetics,
especially in the context of drug discovery. This will allow you to
define strategies for acquisition and analysis of relevant human genetic
and genomic data, as well as interpretation and communication of
results.
Qualifications
Ph.D. in statistical genetics, genetic
epidemiology, statistical bioinformatics, or a related field, with a
minimum of 5 years post-PhD experience
Deep experience in
analyses of human genetic and phenotypic data, interpretation of genetic
associations, and use of functional annotation to identify drug targets
and disease mechanisms
Proficiency in at least one general purpose programming language suitable for statistical genetic analyses (e.g. R or Python)
Demonstrated skills in leading multidisciplinary teams to find creative ways to address scientific questions in drug discovery
Strong record of achievement as reflected in peer-reviewed publications
Contact
For further information, please contact Martijn van de Bunt +45 30 75 02 64
Deadline
June 9th 2019
Millions rely on us To work for Novo Nordisk you will need the skills, dedication
and ambition to change lives for the better for millions of patients
living with diabetes and other chronical diseases. In exchange, we offer
the chance to be part of a truly global workplace, where passion and
engagement are met with opportunities for professional and personal
development.
We are looking for a Scientist experienced in large scale mammalian cell
culture and protein purification, to join our creative and
collaborative team, within the Sensor Technologies section, BioProcess
R&D. Our mission is to develop reagents, consumables, processes and
services to support effective and reproducible processes for getting a
biologics drug to the market. You will be part of a team optimizing
start-to-finish processes for the bioprocess industry.
Essential Responsibilities:
This role includes project and line activities that
will support both tech intake, R-projects, new product introductions,
market support and sales support
Individually or as part of a
team plan, perform, analyze, document and present laboratory
investigations and technical evaluations and when needed act as activity
leader or project manager
Develop, invent and improve new
products and processes for the bioprocess industry, specifically within
the fields of process development, optimization, intensification and
connected manufacturing processes
Act as a mentor/local expert and support peers within the areas of bioprocess process development, optimization and analytics
Present scientific and technical results internally and externally, oral and written communication in Swedish and English
Identify, develop and maintain an external network
Propose new technologies, approve technology and technical solutions within bioprocess workflow
Occasional work on weekends may occur.
For more information or questions regarding the position please
contact Helena Vesterberg (Hiring Manager), e-mail:
helena.vesterberg@ge.com.
Last day to apply is 10th of June.
Qualifications/Requirements:
PhD in biology, medicine, engineering or related Life Science field (or equivalent knowledge/experience)
Experience
in mammalian cell culturing in different formats, including large scale
bioreactor cultivation and different cell types (suspension, adherent,
primary, stem cells)
Good knowledge about protein separation
using chromatography and filtration including Unicorn programming in
Biopharmaceutical process development and/or manufacturing
Experience in culture and process development for production and purification of biologics
Experience
in multiple analysis formats, specifically methods related to biologics
production and sensor technologies within the bioprocess field
Experience in multivariate analysis and software tools such as Matlab and SIMCA
Desired Characteristics:
In order to succeed in this position, you need to
be result-oriented, flexible and creative with a strong collaborative
attitude, focusing on the customer needs
We are looking for
someone with the drive and capability to initiate, plan, perform,
analyze, document and present results to progress our projects forward
The
ideal candidate is looking to share expertise and experience,
supervising and mentoring junior colleagues, utilize his/her network, as
well as integrate new learning and develop new skills
You
should be able to represent the section in scientific/technical
discussions, be one of our experts within a within defined expertise
area (Spectroscopic methods, data modelling and sensor application),
compile and deliver external scientific presentations
About Us:
GE (NYSE:GE) drives the world forward by tackling its biggest
challenges. By combining world-class engineering with software and
analytics, GE helps the world work more efficiently, reliably, and
safely. GE people are global, diverse and dedicated, operating with the
highest integrity and passion to fulfill GEâs mission and deliver for
our customers. www.ge.com
GE Healthcare provides transformational medical technologies and
services to meet the demand for increased access, enhanced quality and
more affordable healthcare around the world. GE works on things that
matter – great people and technologies taking on tough challenges. From
medical imaging, software & IT, patient monitoring and diagnostics
to drug discovery, biopharmaceutical manufacturing technologies and
performance improvement solutions, GE Healthcare helps medical
professionals deliver great healthcare to their patients.
Learn More About Careers at GE
Learn More About GE Healthcare
GE is an Equal Opportunity Employer. Employment decisions are
made without regard to race, color, religion, national or ethnic origin,
sex, sexual orientation, gender identity or expression, age,
disability, and according with all local laws protecting different
status.
Follow us on Twitter, join our LinkedIn Group or become a fan of
our Facebook page. Receive job and event notifications by becoming a
member of the GE Talent Community. Stay up to date on what’s happening
at GE around the globe by checking out the GE Careers Blog. Additional Locations:Sweden;Uppsala;
Etsimme innokasta ja energistä molekyylibiologian asiantuntijaa
vastaamaan AH diagnosticsin molekyylibiologian tuotevalikoiman myynnistä
ja markkinoinnista. Valikoima sisältää markkinoiden uusimpia menetelmiä
ja innovatiivisia tuotteita mm. näillä osa-alueilla:
NGS
CRISPR
Kloonaus
Western Blotting
Q/PCR
DNA-RNA eristys
Tehtävääsi kuuluu AH diagnosticsin tuotevalikoiman myynti ja tuki
Suomessa, asiakassuhteiden ylläpito ja luominen, sekä
markkinointitoimenpiteiden suunnittelu ja koordinointi. Apunasi
tehtävässä ovat pohjoismaiset applikaatiopäälliköt sekä ammattitaitoinen
markkinointitiimi. Osana AH:n tiimiä pääset kehittämään omaa
tietotaitoasi alan uusimpien teknologioiden parissa. Pääset myös
tutustumaan asiakkaidemme tutkimukseen läheltä ja suuri osa työstä onkin
asiakkaiden parissa tehtävää myyntiä.
Keskeisimmät työtehtävät:
Yrityksemme
strategian mukaiset asiakastapaamiset, markkinointikampanjat ja
markkinointimateriaalien luominen sekä erikoisprojektit
Läheinen yhteydenpito ja kommunikaatio olemassa olevien asiakkaiden kanssa sekä uusien asiakassuhteiden luominen
Yhteyden luominen paikallisiin mielipidevaikuttajiin
Erilaisten seminaarien, näyttelyiden ja muiden tapahtumien koordinointi
Markkinatutkimuksien sekä pidemmän aikavälin suunnitelmien luominen
Vastaaminen
paikallisesta tuotemarkkinoinnista yhdessä markkinoinnin ja
paikallistiimin kanssa sekä myynnin kehittymisennusteiden ylläpito
Strategian ja tuotevalikoiman kehitys yhdessä pohjoismaisten kollegoiden kanssa
Haemme spesialistia jolla on:
Akateeminen tutkinto
Mahdollisesti myyntikokemusta
Itsenäinen ja omatoiminen ote työtehtäviin
Intoa kehittää tehtävää ja tuotevalikoimaa
Taustaa
molekyylibiologian tuotteiden parista ja hyvät tiedot NGS, PCR, QPCR,
kloonaus, WB sekä mahdollisesti muista molekyylibiologian menetelmistä
Tietotaitoa ja kiinnostusta työskennellä sekä laitteiden että kulutustavaroiden parissa
Ongelmaratkaisu-, tiimityöskentely- sekä kommunikaatiotaitoja
Mahdollisuus matkustaa paljon Suomessa sekä jonkin verran Suomen ulkopuolella
Voimassa oleva ajokortti
Sujuva suomen ja englannin kielen taito
Tarjoamme erittäin mielenkiintoisen tehtävän, jossa pääset
tutustumaan uusimpiin molekyylibiologian teknologioihin sekä kehittämään
omia ihmissuhdetaitoja erittäin mukavien asiakkaiden ja
mielenkiintoisten tuotteiden parissa. Suomen tiimin tuki ja hyvä henki
auttavat tavoitteiden saavuttamisessa ja työhyvinvoinnissa. AH:n mukana
on mahdollisuus kehittyä ja muokata omaa roolia sekä ottaa lisävastuuta.
Yhteystiedot
Lisätietoja tehtävästä antaa Country Manager Jouni Rantanen sähköpostilla jouni@ahdiagnostics.fi tai puhelimella 010 325 3001.
Hakemuksen palkkatoiveen ja CV:n kanssa voi lähettää osoitteeseen: hr@ahdiagnostics.fi viimeistään 28.06.2019 mennessä.
Aptuit, an Evotec COMPANY, is a worldwide Contract Research
Organization, collaborating with all the major Pharma and Biotech
companies in support of various drug discovery and development projects.
To efficiently support on going activities and needs, we are looking
for a
IV Microbiology, Scientist
To efficiently support ongoing activities and needs, we are looking to a highly motivated person to join the Antibacterial Discovery Department, within the Evotec Infectious Disease Group. The ideal candidate should have a proactive and open attitude to work in a dynamic group.
Reports to
Group Leader
Translational Microbiology
Primary Responsibilities
Be integral part of the Translational Microbiology group
Capable for managing all the aspects characterizing and iv studies, study design, protocol generation and discussion, data analysis, report preparation and final discussion with the Client.
Available for supporting in a matrix environment the structures in DD&D involved in the translational studies.
Sufficient knowledge of applied microbiology required for manipulating bacterial pathogens.
Willing to learn techniques specific for the antibacterial discovery and to support in required activities in case of specific need and workload.
Manage in autonomy all the aspects linked to orders of lab material required for performing experimental activities Be the reference person for training in the area of expertise.
Contribute to the finalisation of proposal (RFP) and support the request for information (RFI) process
Maintains documentation and electronic data archives
Preparing technical reports, scientific publications, and technical presentations for internal meetings
Generate reports as necessary Interact with the Client as the technical expert.
Required skills or attitudes
Bachelor Degree in Biology or Biotechnology or equivalent required. PhD. preferred
At least 5 years of experience in the field of IV pharmacology, in the antibacterial discovery field preferred
On hands experience in other therapeutic area e.g. respiratory, virology
Flexible, energetic and a team player, able to navigate in a complex and very dynamic environment
Lead gracefully under pressure.
Active responder to challenges and to project dynamic changes
Ability to multitask
Positive attitude and sense of urgency
Ability to learn from others and at the same time open to communicate, share and discuss.
Good presentation and communication skills in English
If you are interested please send your CV to Rossana.schiaffini@aptuit.com by 15th of JUNE 2019 reporting the following subject: MICROBIOLOGY 2019
