Ajankohtaista

PhD student position – Laboratory of Stem Cells and Cancer, Université Libre de Bruxelles

Laboratory of Stem Cells and Cancer‐ Université Libre de Bruxelles
http://blanpainlab.ulb.ac.be/

PhD student position
4 years grant (2 years renewable), starting October 2019

Our laboratory is located on the medical campus (Erasme) of Université Libre de Bruxelles (Belgium) and is headed by Prof. Cédric Blanpain. This project will be performed under supervision of Dr. Alexandra Van Keymeulen and in close collaboration with Dr.Christel Pequeux at Université de Liege.

Research Project
Approximatively 75% of breast cancers are estrogen dependent and estrogen receptor‐positive (ER+). Despite the large efficacy of anti‐estrogen treatments, relapse occurs in 30% of cases. In addition, estrogens remain the most powerful treatment to circumvent menopause symptoms. However, their use as menopause hormone treatment (MHT) remains controversial since MHT is associated to an increased risk of breast cancer. A better understanding of the ER signaling upon estrogen or anti‐estrogen treatment in mammary gland and during breast tumorigenesis is thus crucial to develop new tools to target these cancers and to develop a new generation of MHT.

In this context, we aim at answering the following questions:
Aim 1: What is the impact of estrogen signaling on the transcriptional and chromatin landscapes of
the ER+ and ER‐ epithelial cells during tumorigenesis?
Aim 2: Which mechanisms are promoting breast cancer upon MHT treatment during menopause?
Aim 3: How come estetrol treatment during menopause does not promote breast cancer, while it prevents side effects of menopause?

These experiments will constitute a novel and comprehensive definition of the transcriptional and chromatin landscapes of purified individual cell lineages during tumorigenesis and upon MHT. Our results will constitute the basis to highlight new potential targets to treat luminal‐like breast cancer and will also provide precious information to assess how estetrol could safely replace estradiol use as MHT, without increasing breast cancer risk. Finally, they will open new avenues to prevent hormone‐dependent tumorigenesis.

Methods: in vivo models of mammary gland and breast cancer (MMTV‐PyMT, PDX, cell line xenografts), FACS cell sorting, RNAseq, ATACseq, Chipseq, qPCR, 3D cultures.

Skills: Master degree in Biomedical science, molecular biology, biochemistry or equivalent, FELASA certification. High motivation, enthusiasm and scientific curiosity are mandatory. Ability to learn fast,
to work independently, meticulous, good communication would be appreciated.

Contact: To apply, send a motivation letter, a C.V. and two references with their email address to
Alexandra Van Keymeulen (avkeymeu@ulb.ac.be)

Open position for a Postdoctoral researcher in cell biology and laboratory automation at the University of Helsinki

The Faculty of Medicine promotes scientific research of a high standard and is responsible for providing research-based undergraduate and postgraduate education in medicine, dentistry, psychology and logopedics, as well as for the English-language Master’s Programme in Translational Medicine. In addition to its teaching and research activities, the Faculty serves as a significant expert organisation in the healthcare sector and contributes to the discourse on ethics in the field. In terms of research, the Faculty aims for a place among the best medical faculties in the world, while consolidating and strengthening its status as a top-level institution of medical education.

Together with the Helsinki University Hospital (HUS) and the Helsinki Institute of Life Sciences (HiLIFE), the Faculty of Medicine, University of Helsinki, constitutes the Academic Medical Center Helsinki (AMCH). This medical center has been very successful in international comparisons, ranking among the top 10 medical campuses in Europe and among the top 50 globally.

The Faculty of Medicine is seeking a

POSTDOCTORAL RESEARCHER IN CELL BIOLOGY AND LABORATORY AUTOMATION
https://www.helsinki.fi/en/open-positions/postdoctoral-researcher-in-cell-biology-and-laboratory-automation

Dr. Simon Pfisterer is setting up a new research group at the Department of Anatomy, Faculty of Medicine, University of Helsinki, and is looking for a highly motivated postdoctoral researcher to join his multi-disciplinary team.

Hypercholesterolemia, an elevated blood concentration of low-density lipoprotein (LDL) increases the risk for cardiovascular disease, which is one of the most common causes for death worldwide. Individuals respond differently to LDL lowering medications. Currently, we do not understand the cellular defects underlying increased blood LDL concentration and how different responses to LDL lowering therapies arise in individual patients.

It is the goal of the research team to set up state-of-the-art laboratory automation tools to elucidate cellular mechanisms underlying the development of hypercholesterolemia. For this purpose, we will establish a work environment where cell biological research is truly merging with laboratory automation and programming.

We are looking for a highly motivated individual with a commitment to excellence to join this dynamic and collaborative research team. Ideal candidates have a strong background in cell and molecular biology and are eager to acquire new skills such as automated image and data analysis. Key requirements are experience in human cell culture methods, molecular cloning (e.g. generation of expression plasmids), and fluorescence microscopy. Experience in Python programming or automated image analysis are a plus. A PhD degree in Life or Biological sciences, or an MD PhD degree, as well as excellent communication skills in spoken and written English, are required.

We provide opportunities to develop both transferable and scientific skills, with strong support from your laboratory colleagues, and competitive salary (3100-3600 euros/month).

The application, together with the required attachments, must be submitted through the University of Helsinki electronic recruitment system by clicking the Apply for job -link. Internal applicants (i.e. current employees of the University of Helsinki) must submit their applications through the SAP HR portal.

The application should include a cover letter describing previous achievements and motivation for the position (1 page), CV, track record of peer-reviewed publications, and names and contact details of two referees.

The position will be filled once a suitable candidate has been identified. The initial appointment is for one year starting as soon as possible, with the possibility of extension. A six-month trial period will be applied.

Further information is available from simon.pfisterer(at)helsinki.fi

Recent publications:

1.Pfisterer, S. G. et al. Role for formin-like 1-dependent acto-myosin assembly in lipid droplet dynamics and lipid storage. Nat. Commun. 8, 14858 (2017).
2.Sandhu, J., Pfisterer S.G. et al. Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells. Cell 175, 514-529.e20 (2018).
3.Pfisterer, S. G., Peränen, J. & Ikonen, E. LDL-cholesterol transport to the endoplasmic reticulum: current concepts. Curr. Opin. Lipidol. 27, 282–287 (2016).

Due date 01.09.2019 23:59 EEST

Apply the position

Tutkijatohtori tai projektitutkija, mikrobiologia – Jyväskylän yliopisto

https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=2&id=00007630&lang=fi

Jyväskylän keskustassa sijaitsevan yliopiston kauniilla puistokampuksella sykkii monitieteinen ja moderni tiedeyliopisto – ihmisläheinen ja dynaaminen yhteisö, jonka 2 500 asiantuntijaa ja 15 000 opiskelijaa etsivät ja löytävät vastauksia huomisen kysymyksiin. Jyväskylän yliopisto on ollut tulevaisuuden palveluksessa jo vuodesta 1863, jolloin suomenkielinen opettajankoulutus sai alkunsa täältä. Voimanlähteenämme on moniarvoinen vuoropuhelu tutkimuksen, koulutuksen ja yhteiskunnan välillä. Vaalimme tutkimuksen ja koulutuksen tasapainoa sekä ajattelun avoimuutta – sytytämme taidon, tiedon ja intohimon elää viisaasti ihmiskunnan parhaaksi.

Bio- ja ympäristötieteiden laitoksella on haettavana

tutkijatohtorin tai projektitutkijan tehtävä, mikrobiologia, alkaen 1.10.2019 tai mahdollisimman pian sen jälkeen, kahden vuoden määräajaksi.

Bio- ja ympäristötieteiden laitoksella tutkimus jakautuu biotieteisiin ja ympäristötieteisiin. Laitoksen vahvuusalueita ovat evoluutiontutkimus ja biologiset nanotieteet sekä luonnonvarojen ja ympäristön tutkimus. Evoluutiobiologinen tutkimus on suuntautunut evoluutioekologiaan ja evoluutiogenetiikkaan. Laitoksen eri alojen välillä on runsaasti yhteistyötä ja laaja-alaiset tutkimuskohteet kattavat niin DNA-, eliö-, populaatio- kuin ekosysteemitasonkin. Tutkimustoiminnalle on luonteenomaista ennakkoluuloton eri biologian alojen yhdistäminen ja empiirisen tutkimuksen korostaminen. Perus- ja soveltava tutkimus kulkevat luontevasti rinnakkain.

Etsimme tutkijatohtoria (FT) tai projektitutkijaa (FM) tutkimusryhmäämme. Projektissa selvitämme konjugatiivisesti kuljetettavan CRISPR-Cas9 plasmidin ja bakteriofaagien yhteisvaikutusta antibioottivastustuskyvyn poistamisessa bakteeriyhteisöistä. Tutkimme myös resistenssigeenien horisontaalista siirtymistä monimutkaisissa bakteeriyhteisöissä, jotka altistuvat erityyppisille valintapaineille. Yhteisöt näitä tutkimuksia varten muodostetaan pääosin ulostenäytteistä. 

Tutkijatohtorin ja projektitutkijan tehtävistä, kelpoisuusvaatimuksista ja kielitaidosta määrätään yliopiston johtosäännössä ja kielitaito-ohjeistuksissa. Tutkijatohtorilta edellytetään hyvää englannin kielen taitoa.

Etsimme motivoitunutta hakijaa, jolla on koulutus molekylaarisessa mikrobiologiassa tai vastaavalta alalta. Päivittäinen tutkimustyö sisältää perusmikrobiologian tekniikoita, ddPCR analyyseja, sekvensointia ja plasmidien geneettistä muokkausta. Arvostamme kokemusta tilastoanalyyseissa, bioinformatiikassa, sekä kykyä työskennellä itsenäisesti ja osana tutkimusryhmää.

Tutkijatohtorin tehtävä asettuu yliopistojen palkkausjärjestelmän opetus- ja tutkimushenkilöstön tehtävien vaativuustasolle 5-6. Palkkasi on noin 3111 – 4381 euroa kuukaudessa riippuen aiemmasta osaamisestasi ja kokemuksestasi. Projektitutkijan tehtävä asettuu yliopistojen palkkausjärjestelmän opetus- ja tutkimushenkilöstön tehtävien vaativuustasolle 3-4. Palkkasi on noin 2367 – 3245 euroa kuukaudessa riippuen aiemmasta osaamisestasi ja kokemuksestasi. 

Tehtävää täytettäessä käytetään kuuden kuukauden koeaikaa. 

Lisätietoja antaa: Akatemiatutkija Matti Jalasvuori, matti.jalasvuori@jyu.fi.

Sähköiseen hakulomakkeeseen tulee liittää:

1. Ansioluettelo (CV), joka laaditaan hyvää tieteellistä käytäntöä noudattaen sekä ottaen huomioon mahdollisuuksien mukaan ansioluettelomalli (ks. TENK:n ohje). Ansioluetteloon pitää liittää myös kahden varttuneemman akateemisen suosittelijan yhteystiedot
2. Lyhyt hakemuskirje, sisältäen omat tutkimusintressit/-suunnitelman
3. Julkaisuluettelo
4. Tutkintotodistukset

Hakemus tulee jättää viimeistään 18.8.2019 sähköisellä hakulomakkeella.

Two postdoc positions in comparative evolutionary genomics at the University of Lausanne

The Groups of Profs Christophe Dessimoz and Robert Waterhouse are seeking candidates for two 3-year Postdoctoral positions at the Departments of Computational Biology and Ecology & Evolution, University of Lausanne, Switzerland, funded by the Swiss National Science Foundation (SNSF).

Working at the interface between biology and computer science, the Dessimoz Lab, https://lab.dessimoz.org/, seeks to better understand evolutionary and functional relationships
between genes, genomes, and species.

The Waterhouse Group, https://rmwaterhouse.org/lab, is focused on elucidating interactions between gene evolution and gene function through computational interrogation of arthropod genomics data.

Both Groups are members of the SIB Swiss Institute of Bioinformatics, https://www.sib.swiss/

The two Postdocs will lead the evolutionary genomics contributions to a groundbreaking interdisciplinary project in collaboration with the Group of Prof. Bruno Lemaitre, https://lemaitrelab.epfl.ch/ , at the neighbouring École Polytechnique Fédérale de Lausanne.

The overall project aims to develop the computational tools required to fully exploit new genomics data in a framework that also takes advantage of the latest molecular biology tools to achieve combined evolutionary and functional characterisation of the Drosophila immune system. The two Postdocs will work closely together on the project developing and applying
comparative genomics and evolutionary modelling approaches to fully exploit new genomics data, with a biological focus on the insect innate immune system.

The evolutionary genomics part of the project will focus on

(1) extending our current knowledge of immune effectors beyond the canonical repertoires of genes encoding for known antimicrobial peptides, and

(2) exploiting the rich genomics datasets across Drosophila species to trace the evolutionary histories of immune genes.

We seek candidates with demonstrated programming skills in the areas of bioinformatics, computational biology, and comparative genomics.

 Further desirable attributes include knowledge of and interest in orthology delineation, gene family evolution, phylogenetics, gene birth/death, genome-wide synteny, selection and constraint, gene prediction, genome annotation, immunity, infection, insects.

Applications can only be made through the University of Lausanne online recruitment platform , where the full job descriptions will be posted shortly. To ensure full consideration, applications should be received by 30 June 2019.

Note that the SNSF defines the position of ‘Postdoc’ as no more than five years since obtaining a doctorate (i.e. since the doctoral thesis defence).

Informal enquiries can in the meantime be made by writing to:
Prof. Christophe Dessimoz, Christophe.Dessimoz@unil.ch
Prof. Robert Waterhouse, Robert.Waterhouse@unil.ch

Päällikkö, biopankki – liity auttamisen ketjuun! Haemme Veripalvelun biopankkitoiminnoille määräaikaista vetäjää.

Haemme Veripalvelun biopankkitoiminnoille määräaikaista vetäjää.
https://www.veripalvelu.fi/meille-toihin/avoimet-tyopaikat/p%C3%A4%C3%A4llikk%C3%B6-biopankki

Suomessa toimii tällä hetkellä kymmenen biopankkia, joista kaksi toimii Veripalvelussa: Hematologinen biopankki, jonka omistavat Helsingin yliopisto, Hematologi yhdistys ja Veripalvelu, sekä Veripalvelun Biopankki, joka rekrytoi verenluovuttajia. Biopankit ovat biolääketieteellistä tutkimusta tukevia alustoja, joihin kerätään biopankkisuostumuksen antaneiden henkilöiden näytteitä ja tietoja tulevaa tutkimusta varten. Biopankit toimivat osana Veripalvelun tutkimus ja tuotekehitys -osastoa ja ovat viranomaisvalvonnan alaisia.  

Tehtäväsi

Keskeisinä tehtävinäsi ovat:

• biopankin operatiivisesta toiminnasta vastaaminen ja sen kehittäminen
• aineistopyyntöjen käsittelyyn liittyvät tehtävät ja asiakasprosessien kehittäminen 
• sidosryhmäyhteistyö  
• biopankin henkilöstön esimiehenä toimiminen

Tehtävä on määräaikainen sijaisuus ja päättyy 31.12.2020. Tehtävässä voi aloittaa sopimuksen mukaisesti.

Osaamisesi

Odotamme hakijalta tehtävään soveltuvaa ylempää korkeakoulututkintoa, sekä valmiuksia toimia tiiminvetäjänä ja vastata aineistopyyntöjen käsittelystä. Tehtävän hoitaminen vaatii hyviä vuorovaikutustaitoja, monipuolisia teknisiä valmiuksia ja vahvaa englannin kielen taitoa. Eduksi luetaan kokemus biopankki- ja tutkimustoiminnasta sekä kansallisen toimintaympäristön tuntemus ja kokemus viranomaisten säätelemästä toiminnasta.  

Tarjoamme

Tarjoamme haastavan ja merkityksellisen työn innostavassa ja osaavassa työyhteisössä. Olet osa ainutlaatuista auttamisen ketjuamme vapaaehtoisten luovuttajien sekä terveydenhuollon henkilökunnan kanssa. Käytössäsi ovat Veripalvelun monipuoliset henkilöstöedut. Työyhteisön hyvinvointi on meille erityisen tärkeää ja haluamme olla työntekijöillemme erinomainen työpaikka.

Lisätietoja tehtävästä antaa tutkimusjohtaja Jukka Partanen, jukka.partanen@veripalvelu.fi  tai p. 050-3707383.

Jätä hakemuksesi viimeistään 4.7.2019 tämän linkin kautta.  ​

Postdoc in Genomics Discovery and Epidemiology – Novo Nordisk Foundation, Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen

https://jobportal.ku.dk/alle-opslag/?show=149712

The University of Copenhagen is seeking a highly motivated and talented postdoctoral fellow to commence 1 October 2019 or as soon as possible thereafter at the Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences.

The postdoctoral fellowship is part of the Novo Nordisk Foundation Center for Basic Metabolic Research International Postdoctoral Program www.cbmr.ku.dk/postdocprogram.

The postdoctoral fellow will receive a competitive package including salary and running costs for three years, and be part of an international scientific collaboration at the Maersk Tower www.maersktower.ku.dk.

Job description

The fellowship is aimed at early career researchers with a basic science background or clinicians who aspire to a career in academic medicine. We are particularly interested in candidates who are familiar with integrative research approaches within the broad area of basic metabolic research with an application towards human pathophysiology. The Center’s vision is to strengthen interdisciplinary research that transforms the basic understanding of mechanisms involved in metabolic health and disease, and to accelerate this knowledge toward new prevention and treatment strategies. Information about the Center can be found at www.cbmr.ku.dk.

The postdoc position is in the Genomics Discovery and Epidemiology Group headed by Associate Professor Tuomas Kilpeläinen. The research group investigates how genetic variation contributes to obesity and related metabolic disorders and interacts with the environment, modifying the effect of physical activity, diet, and other lifestyle factors on weight gain and metabolic health. You can read more about the Kilpeläinen Group at www.cbmr.ku.dk/research/human-genomics-and-metagenomics-in-metabolism/kilpelainen-group.

Project description

Insulin resistance, dyslipidaemia, and increased risk of type 2 diabetes are closely linked to obesity, but there is wide individual variability in the metabolic tolerance for carrying excess body fat. Among patients who are morbidly obese, up to 10% do not show any sign of metabolic dysfunction at all. In contrast, lipodystrophic patients who are unable to form subcutaneous adipose tissue, typically suffer from severe insulin resistance and other metabolic abnormalities. Overfeeding experiments have shown that given similar relative weight gain, individuals may be either protected from or predisposed to metabolic dysfunction. Furthermore, results from weight loss interventions for type 2 diabetes have shown that non-overweight individuals respond to substantial weight loss just as well as the obese in terms of conversion to normal glucose tolerance.

The aim of the present project is to examine the role of genetic variation in the individual relationship between adiposity and metabolic dysfunction in human populations. We expect that the postdoc will develop a project that, through the understanding of the role of genetic diversity, will elucidate the causal mechanisms that couple obesity to metabolic dysfunction and open avenues for identifying individuals with the highest risk of developing insulin resistance and type 2 diabetes if they gain weight.

Profile

We are looking for a highly motivated and enthusiastic scientist with the following competencies and qualifications:

• Experience in statistical programming (e.g. R, SAS)
• Expertise in applying statistical analyses to test biological hypotheses
• Experience in epidemiological research
• Strong interest in research on obesity and metabolic disorders
• Proven track record showing continuous scientific productivity in peer-reviewed journals
• Interest in co-supervising PhD fellows and MSc students
• Excellent English communication skills, both written and oral

Eligibility

The applicant must hold a PhD within a relevant discipline such as medicine, biology, biochemistry, molecular biology, bioinformatics, pharmacy or medical engineering. The PhD degree must preferably be awarded from a university outside of Denmark. The program is also open for applicants with a Danish PhD degree who can document at least 12 months full-time research experience from outside Denmark.

You are not eligible to apply for the program if you have been employed in a postdoctoral position for more than one year at the University of Copenhagen prior to the commencement of the fellowship.

Selection

Selection of postdoctoral fellows is based on academic achievements, research experience and interviews. A mandatory interview visit for the shortlisted applicants comprises interviews with PI and co-PI and a tour of the Center facilities. The Center will pay for travel and accommodation for selected applicants in association with the interview visit.

The University of Copenhagen International Staff Mobility office offers support and assistance to all international researchers on all issues related to moving to and settling in Denmark. Read more at www.ism.ku.dk and www.workindenmark.dk.

The applicant must fulfil the following criteria:

• A strong CV, having published in high-impact journals and presented at international meetings
• An enthusiastic interest in basic metabolic research
• The ability to manage your own academic research and associated activities
• The ability to contribute ideas for new research projects
• Evidence of excellent interpersonal skills and leadership, with the ability to communicate research ideas and results in a clear and logical way and the ability to confidently and effectively interact with colleagues and the broader research community

Terms of employment

The employment as postdoc is a full time position for 3 years. Starting date is 1 October 2019.

Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Depending on qualifications, a supplement may be negotiated.

Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.

Questions

For further information about the position, please contact Associate Professor Tuomas Kilpeläinen at tuomas.kilpelainen@sund.ku.dk. Questions regarding the CBMR International Postdoctoral Program must be directed to cbmr@sund.ku.dk. For questions regarding the recruitment procedure, please contact SUND HR CBMR at mlr@sund.ku.dk.

Application procedure

Your online application must be submitted in English by clicking ‘Apply now’ below. Furthermore, your application must include the following documents/attachments – all in PDF format:

• Cover letter expressing the motivation and previous research experience of the applicant (max 1 page)
• Curriculum vitae
• Copy of the PhD degree certificate and the Master degree certificate. In case the PhD has not yet been completed, a written statement from the supervisor is acceptable
• List of publications
• References (name and contact details of at least two references)

The application deadline is 7 July 2019 at 23.59pm CET.

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

The further process

After the expiry of the deadline for applications, the authorised recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether an unbiased assessor has passed their application for assessment. Once the assessment work has been completed, each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at www.employment.ku.dk/faculty/recruitment-process.

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

The University of Copenhagen wishes to reflect the diversity of society and welcome applications from all qualified candidates regardless of personal background.

Postdoctoral Researcher, cell and molecular biology – Institute of Biomedicine, University of Eastern Finland (Kuopio campus)

https://duunitori.fi/tyopaikat/tyo/postdoctoral-researcher-cell-and-molecular-biol-stse-10431399

The University of Eastern Finland, UEF, is one of the largest multidisciplinary universities in Finland. We offer education in nearly one hundred major subjects, and are home to approximately 15,500 students and 2,500 members of staff. We operate in Joensuu and Kuopio. In international rankings, we are ranked among the leading universities in the world.

The Faculty of Health Sciences operates at the Kuopio Campus of the University of Eastern Finland. The Faculty offers education in medicine, dentistry, nutrition and pharmacy, as well as in some other central fields of the health care sector. The Faculty is research-intensive, and its internationally recognised research activities are closely linked to the strategic research areas of the University. There are approximately 2 500 degree students and about 450 PhD students in the Faculty. The faculty has 680 staff members. http://www.uef.fi/en/ttdk/etusivu

We are now inviting applications for

a Postdoctoral Researcher (cell and molecular biology), School of Medicine, Institute of Biomedicine, Kuopio Campus

An Academy of Finland funded Postdoctoral Researcher position is available in the laboratory of Dr Kirsi Ketola at the Institute of Biomedicine, UEF School of Medicine. The laboratory’s translational research programme aims at understanding the mechanisms, detection and targeting of highly aggressive treatment-resistant cancer subtypes, such as neuroendocrine prostate cancer.

The projects employ multi-disciplinary approaches including modern cell and molecular biology techniques ranging from high-content cellular imaging and screening to next generation sequencing, epigenetics and drug discovery. We are seeking a highly motivated candidate with experience in cellular imaging, bioinformatics and/or biomarker and drug discovery. Experience in prostate cancer biology, bioassay development or single cell analyses on lineage reprogramming (imaging, sequencing) is an asset.

The position gives opportunities to take part, along with the group leader, in supervising PhD and MSc students, scientific writing, grant applications, scientific collaborations and teaching in suitable areas. Outstanding communication skills are required.

A person to be appointed as a postdoctoral researcher shall hold a suitable doctoral degree. Positions of postdoctoral researchers shall always be filled for a fixed term (UEF University Regulations, Section 31).

The person to be appointed to the Postdoctoral Researcher Position is required to hold a doctoral degree, which may not have been completed more than five years ago at the time of accepting the position. In this context, the 5 years refer to a net period of time, which does not include maternity leaves, parental leaves, or military service, etc.

The language requirements associated with the position are defined in the Government Decree 770/2009. Members of the university’s teaching and research staff are required to have command of the language they give teaching in (Finnish or Swedish). The Dean of the faculty may grant an exemption from the language proficiency requirements laid down in the Government Decree.

The position is filled for a fixed-term of 3 years with a possibility of extension. The full-time position will start in September 2019, or later by agreement. Positions of postdoctoral researchers shall always be filled for a fixed term (UEF University Regulations, Section 31).

The salary of the position is determined in accordance with the salary system of Finnish universities and is based on level 5 of the job requirement level chart for teaching and research staff (€2,935.55/ month). In addition to the job requirement component, the salary includes a personal performance component, which may be a maximum of 50 % of the job requirement component.

For further information on the position, please contact: Academy Researcher Kirsi Ketola, email: kirsi.ketola@uef.fi, phone +358 29 4454098. For further information on the application procedure, please contact

HR Secretary Tellervo Rajanto, email: tellervo.rajanto@uef.fi, phone +358 29 4454278.

A probationary period is applied to all new members of the staff.

The electronic application should contain the following appendices:

– a résumé or CV

– a list of publications

– motivation letter

– copies of the applicant’s academic degree certificates/diplomas, and copies of certificates/diplomas relating to the applicant’s language proficiency, if not indicated in the academic degree certificates/diplomas

The application needs to be submitted no later than 5.8.2019 (by 24.00 hours Finnish time) by using the electronic application form.

WWW-osoite http://www.uef.fi
Yhteystiedot Academy Researcher Kirsi Ketola, email: kirsi.ketola@uef.fi, phone +358 29 4454098. For further information on the application procedure, please contact
Työpaikan osoite 70211 KUOPIO
Työaika kokoaikatyö
Työn kesto yli 12 kuukautta
Haku päättyy 05.08.2019
Ilmoitus jätetty 19.06.2019
Ilmoitusnumero 10006817

Post-Doctoral Positions in Drug Abuse/Pain Research at the University of Michigan

We are currently seeking Post-Doctoral Fellows with experience in preclinical and cellular models of drug abuse and/or pain. Ongoing projects are related to the understanding of substance abuse, the development of medications the management of opiate and/or cocaine abuse and pain. The selected candidates may be eligible to join  our NIH  training grant on the Biology of Drug Abuse (seehttps://sites.google.com/umich.edu/bda/home).

Candidates should have strong communication skills and technical expertise, with a focus on either in vitro (e.g., cell signaling, immunohistochemistry, electrophysiology) or in vivo (e.g., self-administration or pain models, circuitry analysis) methods. An ability to integrate in vivo and in vitro findings will be an advantage. Applicants should have completed (or be about to complete) an MD or Ph.D. or equivalent degree in a relevant discipline (e.g., biochemistry, pharmacology, neuroscience, biological psychology, physiology etc.) and must be US citizens or permanent residents of the USA.

Positions are available starting late summer/early fall. For more information contact John Traynor (jtraynor@umich.edu) or Emily Jutkiewicz (ejutkiew@umich.edu) or speak to Emily or John at the INRC meeting.

To apply, e-mail an up-to-date CV with the names of 3 referees to jtraynor@umich.edu.

2 postdoctoral positions and 2 graduate student positions at the University of Oulu

Two postdoctoral positions (application and more information in the link):

https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=1&id=00007562&lang=en

Two open postdoctoral researcher positions are available in the field of molecular cancer cell biology, systems genetics and functional genomics in the research groups led by Drs Aki Manninen (www.oulu.fi/biocenter/groups/manninen) and Gonghong Wei (www.oulu.fi/biocenter/groups/wei) at the Faculty of Biochemistry and Molecular Medicine (FBMM), Biocenter Oulu, University of Oulu, Oulu, Finland. We are looking for ambitious, highly motivated candidates who have enthusiasm and ability to work hard both independently and as a team member to tackle challenging problems to achieve common goals. The positions are funded for 3 years.

This project aims at characterizing integrin-associated molecular machineries driving cancer-promoting effects in prostate cancer cells focusing on the crosstalk between hemidesmosomes and focal adhesions. Transcriptional regulatory mechanisms of integrins, as well as crosstalk between integrin signaling, androgen receptor pathway and other relevant prostate cancer associated pathways will be investigated. Genomic analysis will focus on systems identification of causal genetic variants, causative genes and relevant pathways as well as their functional and biological effects on prostate cancer susceptibility, initiation and progression.

The project utilizes 3D cell culture models where, in addition to established prostate cancer cell lines, we develop novel study systems based on prostate cancer patient-derived prostate organoids. The candidates will also employ advanced microscopy techniques, virus-based genomic engineering, CRISPR-Cas9-mediated genome editing and state-of-art cancer genetics and functional genomics approaches. Further reading: Myllymäki et al., (2019), MCP, doi: 10.1074/mcp.RA118.001095.; Gao et al., (2018), Cell, 174:576-589.; Huang et al., (2014), Nat Genet. 46:126-135.; Zhang, K. et al. (2017) Oncogene, doi: 10.1038/onc.2017.177. 

Two PhD-student positions (application and more information in the link):

https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=1&id=00007583&lang=en

Applications are invited for two full-time doctoral student positions for a maximum of four years, starting at the earliest on 01.01.2020 in a Biocenter Oulu research project headed by Professors Gonghong Wei and Aki Manninen in the cancer genomics research unit, Faculty of Biochemistry and Molecular Medicine.

Our work aims to discover the roles of novel transcription factors and epigenetic regulators in cancer predisposition and progression, and to explore how these proteins misregulate genome-wide gene expression in particular during prostate cancer development. We also focus on the identification of causal genetic variants, genes and relevant pathways as well as their functional and biological effects on prostate cancer susceptibility, initiation and progression.

The positions will be supervised by Professors Gonghong Wei and Aki Manninen and are focused on mapping genome-wide binding sites (cistrome) for novel transcriptional regulators in prostate cancer cells and tissues. We will further investigate the cistrome-enriched prostate cancer risk-associated variants and thus integrate the eQTL, epigenome and three-dimensional (3D) genome data to unravel the biological roles of causal variants and genes. Functional validation of selected genetic variants, target genes and other relevant risk factors will be performed using genetically engineered prostate cancer models. The projects utilize 3D cell culture models, potential patient-derived prostate organoids/xenografts, mouse models, advanced microscopy techniques, viral gene transfer-based genomic engineering, and CRISPR-Cas9-mediated genome editing as well as other molecular cell biology methods and functional genetics/genomics approaches.

PhD within molecular developmental biology – Nord University, Bodø, Norway

https://www.researchgate.net/job/931235_PhD_within_molecular_developmental_biology

PhD fellowship is available at the Faculty of Biosciences and Aquaculture, Nord University (Bodø, Norway) on the project: Biogenesis and functions of small regulatory RNAs in embryonic development of zebrafish.

The position is for 3 years and will be available from August 1st. 2019.

The PhD is in molecular developmental biology, and zebrafish is the primary model. Regulation of early embryonic development is a multifaceted process involving many classes of regulatory elements. Ambiguity of developmental origin of these elements is a major difficulty in studying their functional roles This study combines functional genomics and high-throughput sequencing approaches in order to identify biogenesis, expression features, and roles of chosen elements. The focus is on two classes of small regulatory RNAs: miRNA and piRNA, which are both present in the early embryo yet their roles are poorly determined.

We offer

The annual salary for doctoral researchers is set from wage level 51 ( 449.400) in the Norwegian State Salary Scale.

• Advantages within the Government Pension Fund for borrowing, insurance and pension
• Creative and collegial working environment
• A workplace with steady progressive development
• Flexible working hours
• Active university sports team

General information

The person who is appointed must abide by the applicable laws, agreements, and directives. The responsibilities and duties associated with the position may change with future reorganization at Nord University.

The public sector workforce is expected to reflect the diversity of the population in general. Nord University therefore encourages qualified candidates with disabilities, gaps in their CV, immigrant backgrounds or different life experience to apply. Nord University practices moderate allocation according to gender quotas in accordance with the Basic Agreement for State Employees.

If applicants indicate they have disabilities or gaps in their CV, their details may be used anonymously for the purposes of recording whether this target is achieved or not.

Contact information

Further information about the position can be obtained by contacting :

Professor Igor S. Babiak, e-mail: igor.s.babiak@nord.no, telephone: +47 75 51 79 22
Office Manager Irene Stork, e-mail: irene.stork@nord.no

Application

Applications must be submitted electronically by June 20th 2019.

The application should include:

• Cover letter outlining the candidate’s suitability for this position (one page), and a project outline based on the project (maximum2 pages)
• must be submitted.
• Curriculum vitae, including a list of publications (maximum 3 pages)
• Certified copies of academic degree transcripts and any other relevant qualifications
• Contact details for 2 – 3 references
• All documents must be uploaded as attachments to the electronic application form.
• Signed consent form PhD (if relevant)

All documents must be uploaded as attachments to the electronic application form.

It is the applicant’s responsibility to submit the complete documentation within the deadline.

After the application deadline, an applicant list will be announced publicly. Applicants asking for confidentiality must specifically explain the reasons for this in their application. Even so, the information can be published if the reasons for confidentiality are not found relevant. In such the case, an applicant will be given notice prior to the announcement, and he/she will have opportunity to withdraw the application

Refnr. 30085016
Applicationdeadline: 20.06.2019

The candidate should have an MSc degree (or equivalent) in natural sciences, preferably in one of the following fields: Developmental Biology; Molecular Cell Biology; Genomics; Bioinformatics.Education and experience in one or more of the following areas is required: molecular developmental biology, RNA biology, transcriptomics, or genomics.Hands-on experience in RNA-seq, RNA bioinformatics, epigenomics, non-coding RNAs, or zebrafish development are advantageous for the position.Proficiency in oral and written English is essential and must be documented either by the Norwegian Higher Education Entrance Qualification or internationally recognised certificates, such as TOEFL, IELTS, APIEL or similar. Skills in Scandinavian language is an advantage for the position.The selected candidate will join the PhD programme in Aquatic Biosciences at Nord University and is expected to complete a doctorate within the three-year project period. The candidate should fulfill the admission requirements of this PhD programme at the Faculty of Biosciences and Aquaculture and participate in the training components stipulated in regulations of the PhD program. Application for admission to the programme must be submitted within three months after taking up the position. For admission requirements and regulations, see our see our web page.

Nord University

Global challenges demand new insight, innovative solutions and local legitimacy. Nord University is a young university with strong regional ties and a global perspective. We are committed to delivering relevant educational programmes and research, with a focus on blue and green growth, innovation and entrepreneurship, and welfare, health and education. Nord University has 12,000 students and 1,400 employees at nine study locations in central and northern Norway.The Faculty of Biosciences and Aquaculture (FBA) educates people who promote sustainable and innovative development to meet global challenges in food production, climate and environment. The Faculty is an international arena for education, research and knowledge dissemination, with employees and students from 25 different countries. The Faculty offers a PhD in Aquatic Biosciences. The Faculty of Biosciences and Aquaculture has 900 students and 150 employees in Bodø and Steinkjer. The professional community is organised into the following divisions: Aquaculture, Ecology, Genomics and Animal Science, Production and Welfare.Read more: www.nord.no/en/fba