Ajankohtaista

Open position for a doctoral student in Structural Biology at the University of Oulu

The University of Oulu (http://www.oulu.fi/english/) is one of the largest universities in Finland, with approximately 15 000 students and 3 000 employees. The University of Oulu Graduate School (UniOGS) (http://www.oulu.fi/uniogs/) provides the framework and conditions for high-quality, research-driven doctoral education at the University of Oulu, and field-specific doctoral training is provided by its multidisciplinary doctoral programmes. Biocenter Oulu (BCO) (http://www.oulu.fi/biocenter/) offers a high-level international multidisciplinary environment supplied with cutting-edge infrastructures. Under this framework, the Health and Biosciences Doctoral Programme (HBS-DP) (http://www.oulu.fi/uniogs/dp/hbsdp) offers doctoral training in clinical medicine, biomedicine, biochemistry, molecular medicine, dentistry, health sciences, and medical technology.

Subject field and the description of the position
Applications are invited for a full-time PhD student position for a maximum of four years, starting on January 1^st 2020, in a Biocenter Oulu research project headed by Professor Petri Kursula in the Biomedical Structural Biology research unit, Faculty of Biochemistry and Molecular Medicine.

Our main focus is the structural biology of the myelin sheath. Most myelin proteins are either integral or peripheral membrane proteins, often involved in either autoimmune or inherited demyelinating disease. We also have a keen interest in other structural biology problems, including protein-membrane interactions at the molecular level, high-resolution crystallography, and the structural basis of various neurological diseases. More details can be found at https://www.uib.no/en/rg/petrikursula.

The position is supervised by Prof. Petri Kursula and Dr. Salla Ruskamo and is focused on the 3D molecular and atomic structure of the myelin sheath, as well as the molecular mechanisms of mutations causing human hereditary neuropathies.

Required Qualifications and assessment
To successfully occupy the PhD student position, the candidate must possess an MSc degree in biochemistry, biophysics, protein science, or another relevant field. Practical experience in protein research will be highly valued, and a keen interest in biophysics and structural biology are required. The MSc degree must have been completed with good grades by December 2019, preferably by the call deadline. Ability to pursue independent research as a member of a team and excellent oral and written communication skills in English are expected.

The position is intended for an Early Stage Researcher (ESR) who, according to the ”European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers”, is defined as a researcher in the first four years (full-time equivalent) of his/her research activity, including the period of research training. Applicants will be either starting their doctoral training, or will have completed no more than two full years of training (adjusted for possible previous part-time status) at the time the position is filled. The selected candidate will carry out his/her doctoral studies in the HBS-DP of the UniOGS and must meet the minimal requirements to receive doctoral study rights as defined in http://www.oulu.fi/uniogs/requirements_for_admission.

Salary
The salary of the selected doctoral student will be initially set on level 2, and later on levels 2 – 4, of the national salary scale for the teaching and research staff of Finnish universities. In addition, a supplementary remuneration is given for personal achievement and performance (max. 50 %). In practice, the salary is roughly 2200 – 2700 € per month for an early stage researcher, depending on qualifications and progress of the doctoral thesis.

Since this call is for a starting PhD student, the position will be filled for a four-year period, beginning on 1 January 2020. A six-month trial period will be applied in the position.

Application procedure
Applications, together with all relevant enclosures, must be submitted using the electronic application system by July 19th, 2019. Applications sent by email will not be considered. Apply at https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=1&id=00007516&lang=en

The following documents must be attached to the application (in English)

1. Complete CV containing the contact information of 2-3 sources for references (Max. size of the attachment: 5 Mbytes)
2. Motivation letter (maximum 1 page) describing prior experience, research interests, and career plans (1-2 pages; max. size of the attachment: 2 Mbytes).
3. Certificates/Diplomas: Scanned electronic copies of diplomas and transcripts of the records of relevant previous degrees. If the original documents are not in English, Finnish, or Swedish, each document must be accompanied by an official certified translation into English or Finnish. (Max. size of the attachment: 2 Mbytes)

Other relevant information
Eligible applicants fitting best in the expected research profile will be invited to an on-site or remote interview. All applicants will be notified when the selection process is completed.

Contact
Prof. Petri Kursula, e-mail: petri.kursula(at)oulu.fi

Open position for a doctoral student in FETopen MindGAP project, University of Oulu

Research Scientist – miDiagnostics, Leuven, Flemish Region, Belgium

https://www.linkedin.com/jobs/view/1289763911/?refId=3d7d4545-14be-43c7-8f4c-a58933feed15&trk=eml-vjr-similar-job-title&midToken=AQFgumZyIt6sOQ&trkEmail=eml-email_jobs_viewed_job_reminder_01-null-37-null-null-41f64x%7Ejwcdutfn%7E2y-null-jobs%7Eview

You will be part of a dynamic, international and multidisciplinary team that develops a completely new medical diagnostic device to be used at the point of need. As “Process Development Technician” you will support processing activities related to back-end processing of the silicon-based nFP. You will generate the necessary data and knowledge to make the transition from test prototypes to market ready products. You will also provide the development teams with the necessary components to support the prototype manufacturing and testing needs.

Responsibilities

You will become part of a team of scientists and engineers that is developing a new device for molecular diagnostic testing. In your role of Molecular Biologist, you will develop and optimize new assay principles for nucleic acid purification, extraction, amplification and detection on a silicon chip. In particular, you will:

• Develop new methods for nucleic acid extraction within a silicon chip
• Develop new methods for nucleic acid amplification and detection
• Develop new sample prep methodologies to purify nucleic acids from diverse clinical sample specimens
• Design and optimize assays to be run on the silicon chip
• Interact with silicon chip designers and process engineers to match the silicon chip to the needs of the molecular biology and vice versa
  
  

Profile and competences:

• You have a MSc or PhD degree in molecular biology, (bio)chemistry engineering or bioscience engineering
• Ideally, several years of experience in PCR, assay design and/or other ways of nucleic acid detection technologies
• Experience in de novo assay development, not based on existing kits, is a plus
• A keen interest in novel technologies for molecular diagnostics
• A thorough understanding of chemistries related to nucleic acids and solid phases is a plus
• Experience in microfluidics is a strong plus
• Hands-on and resourceful problem solver is a must
• Attention to detail, works in a structured and methodological way
• Team-player
• Excellent communicator
• Fluent in English

Principal Scientist, Genetics – Novo Nordisk, Måløv, DK

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Bioinformatics and Data Mining, Global Research Technologies

Denmark – Måløv

Do you like working on the intersection between biology and data, and drive the use of genetics for drug discovery? Then this job might be right for you. We are looking for a scientist with deep expertise in using human genetics, experience for drug discovery, strong leadership skills, and the ability to lead our representation in key external partnerships and consortia to support our drug discovery pipeline.

About The Department

The Department of Bioinformatics and Data Mining combines strong computational skills with biological insights through the integrative analysis of internal and external biomedical data. Our analytical expertise spans a wide range of areas, from genetics, sequence analysis, many different omics, pathway analysis, to text-mining. We contribute to all aspects of pre-clinical research projects at Novo Nordisk, where we act as data-driven experts and participate in external collaborations with academic and biotech partners. Our work results in real impacts on new medicines for highly important diseases of unmet medical need.

The position

Your main responsibility will be to work closely with our scientists in Global Research to drive the application of human genetics in drug discovery to positively impact the success of our R&D pipeline. As such you will have extensive expertise in human genetics, especially in the context of drug discovery. This will allow you to define strategies for acquisition and analysis of relevant human genetic and genomic data, as well as interpretation and communication of results.

Qualifications

• Ph.D. in statistical genetics, genetic epidemiology, statistical bioinformatics, or a related field, with a minimum of 5 years post-PhD experience
• Deep experience in analyses of human genetic and phenotypic data, interpretation of genetic associations, and use of functional annotation to identify drug targets and disease mechanisms
• Proficiency in at least one general purpose programming language suitable for statistical genetic analyses (e.g. R or Python)
• Demonstrated skills in leading multidisciplinary teams to find creative ways to address scientific questions in drug discovery
• Strong record of achievement as reflected in peer-reviewed publications
  
  

Contact

For further information, please contact Martijn van de Bunt +45 30 75 02 64

Deadline

June 9th 2019

Millions rely on us
To work for Novo Nordisk you will need the skills, dedication and ambition to change lives for the better for millions of patients living with diabetes and other chronical diseases. In exchange, we offer the chance to be part of a truly global workplace, where passion and engagement are met with opportunities for professional and personal development.

Scientist – GE Healthcare, Uppsala, Uppsala County, Sweden

https://www.linkedin.com/jobs/view/1283100879/?refId=3d7d4545-14be-43c7-8f4c-a58933feed15&trk=eml-vjr-similar-job-title&midToken=AQFgumZyIt6sOQ&trkEmail=eml-email_jobs_viewed_job_reminder_01-null-45-null-null-41f64x%7Ejwcdutfn%7E2y-null-jobs%7Eview

Role Summary:

We are looking for a Scientist experienced in large scale mammalian cell culture and protein purification, to join our creative and collaborative team, within the Sensor Technologies section, BioProcess R&D. Our mission is to develop reagents, consumables, processes and services to support effective and reproducible processes for getting a biologics drug to the market. You will be part of a team optimizing start-to-finish processes for the bioprocess industry.

Essential Responsibilities:

• This role includes project and line activities that will support both tech intake, R-projects, new product introductions, market support and sales support
• Individually or as part of a team plan, perform, analyze, document and present laboratory investigations and technical evaluations and when needed act as activity leader or project manager
• Develop, invent and improve new products and processes for the bioprocess industry, specifically within the fields of process development, optimization, intensification and connected manufacturing processes
• Act as a mentor/local expert and support peers within the areas of bioprocess process development, optimization and analytics
• Present scientific and technical results internally and externally, oral and written communication in Swedish and English
• Identify, develop and maintain an external network
• Propose new technologies, approve technology and technical solutions within bioprocess workflow

Occasional work on weekends may occur.

For more information or questions regarding the position please contact Helena Vesterberg (Hiring Manager), e-mail: helena.vesterberg@ge.com.

Last day to apply is 10th of June.

Qualifications/Requirements:

• PhD in biology, medicine, engineering or related Life Science field (or equivalent knowledge/experience)
• Experience in mammalian cell culturing in different formats, including large scale bioreactor cultivation and different cell types (suspension, adherent, primary, stem cells)
• Good knowledge about protein separation using chromatography and filtration including Unicorn programming in Biopharmaceutical process development and/or manufacturing
• Experience in culture and process development for production and purification of biologics
• Experience in multiple analysis formats, specifically methods related to biologics production and sensor technologies within the bioprocess field
• Experience in multivariate analysis and software tools such as Matlab and SIMCA

Desired Characteristics:

• In order to succeed in this position, you need to be result-oriented, flexible and creative with a strong collaborative attitude, focusing on the customer needs
• We are looking for someone with the drive and capability to initiate, plan, perform, analyze, document and present results to progress our projects forward
• The ideal candidate is looking to share expertise and experience, supervising and mentoring junior colleagues, utilize his/her network, as well as integrate new learning and develop new skills
• You should be able to represent the section in scientific/technical discussions, be one of our experts within a within defined expertise area (Spectroscopic methods, data modelling and sensor application), compile and deliver external scientific presentations

About Us:

GE (NYSE:GE) drives the world forward by tackling its biggest challenges. By combining world-class engineering with software and analytics, GE helps the world work more efficiently, reliably, and safely. GE people are global, diverse and dedicated, operating with the highest integrity and passion to fulfill GE’s mission and deliver for our customers. www.ge.com

GE Healthcare provides transformational medical technologies and services to meet the demand for increased access, enhanced quality and more affordable healthcare around the world. GE works on things that matter – great people and technologies taking on tough challenges. From medical imaging, software & IT, patient monitoring and diagnostics to drug discovery, biopharmaceutical manufacturing technologies and performance improvement solutions, GE Healthcare helps medical professionals deliver great healthcare to their patients.
Learn More About Careers at GE



Learn More About GE Healthcare

GE is an Equal Opportunity Employer. Employment decisions are made without regard to race, color, religion, national or ethnic origin, sex, sexual orientation, gender identity or expression, age, disability, and according with all local laws protecting different status.

Follow us on Twitter, join our LinkedIn Group or become a fan of our Facebook page. Receive job and event notifications by becoming a member of the GE Talent Community. Stay up to date on what’s happening at GE around the globe by checking out the GE Careers Blog.
Additional Locations:Sweden;Uppsala;

Product Specialist, Molecular Biology – AH diagnostics, Helsinki

https://www.linkedin.com/jobs/view/1272461937/?refId=3d7d4545-14be-43c7-8f4c-a58933feed15&trk=eml-vjr-similar-job-title&midToken=AQFgumZyIt6sOQ&trkEmail=eml-email_jobs_viewed_job_reminder_01-null-38-null-null-41f64x%7Ejwcdutfn%7E2y-null-jobs%7Eview

Tuotespesialisti – Molekyylibiologia

Etsimme innokasta ja energistä molekyylibiologian asiantuntijaa vastaamaan AH diagnosticsin molekyylibiologian tuotevalikoiman myynnistä ja markkinoinnista. Valikoima sisältää markkinoiden uusimpia menetelmiä ja innovatiivisia tuotteita mm. näillä osa-alueilla:

• NGS
• CRISPR
• Kloonaus
• Western Blotting
• Q/PCR
• DNA-RNA eristys

Tehtävääsi kuuluu AH diagnosticsin tuotevalikoiman myynti ja tuki Suomessa, asiakassuhteiden ylläpito ja luominen, sekä markkinointitoimenpiteiden suunnittelu ja koordinointi. Apunasi tehtävässä ovat pohjoismaiset applikaatiopäälliköt sekä ammattitaitoinen markkinointitiimi. Osana AH:n tiimiä pääset kehittämään omaa tietotaitoasi alan uusimpien teknologioiden parissa. Pääset myös tutustumaan asiakkaidemme tutkimukseen läheltä ja suuri osa työstä onkin asiakkaiden parissa tehtävää myyntiä.

Keskeisimmät työtehtävät:

• Yrityksemme strategian mukaiset asiakastapaamiset, markkinointikampanjat ja markkinointimateriaalien luominen sekä erikoisprojektit
• Läheinen yhteydenpito ja kommunikaatio olemassa olevien asiakkaiden kanssa sekä uusien asiakassuhteiden luominen
• Yhteyden luominen paikallisiin mielipidevaikuttajiin
• Erilaisten seminaarien, näyttelyiden ja muiden tapahtumien koordinointi
• Markkinatutkimuksien sekä pidemmän aikavälin suunnitelmien luominen
• Vastaaminen paikallisesta tuotemarkkinoinnista yhdessä markkinoinnin ja paikallistiimin kanssa sekä myynnin kehittymisennusteiden ylläpito
• Strategian ja tuotevalikoiman kehitys yhdessä pohjoismaisten kollegoiden kanssa

Haemme spesialistia jolla on:

• Akateeminen tutkinto
• Mahdollisesti myyntikokemusta
• Itsenäinen ja omatoiminen ote työtehtäviin
• Intoa kehittää tehtävää ja tuotevalikoimaa
• Taustaa molekyylibiologian tuotteiden parista ja hyvät tiedot NGS, PCR, QPCR, kloonaus, WB sekä mahdollisesti muista molekyylibiologian menetelmistä
• Tietotaitoa ja kiinnostusta työskennellä sekä laitteiden että kulutustavaroiden parissa
• Ongelmaratkaisu-, tiimityöskentely- sekä kommunikaatiotaitoja
• Mahdollisuus matkustaa paljon Suomessa sekä jonkin verran Suomen ulkopuolella
• Voimassa oleva ajokortti
• Sujuva suomen ja englannin kielen taito

Tarjoamme erittäin mielenkiintoisen tehtävän, jossa pääset tutustumaan uusimpiin molekyylibiologian teknologioihin sekä kehittämään omia ihmissuhdetaitoja erittäin mukavien asiakkaiden ja mielenkiintoisten tuotteiden parissa. Suomen tiimin tuki ja hyvä henki auttavat tavoitteiden saavuttamisessa ja työhyvinvoinnissa. AH:n mukana on mahdollisuus kehittyä ja muokata omaa roolia sekä ottaa lisävastuuta.

Yhteystiedot

Lisätietoja tehtävästä antaa Country Manager Jouni Rantanen sähköpostilla jouni@ahdiagnostics.fi tai puhelimella 010 325 3001.

Hakemuksen palkkatoiveen ja CV:n kanssa voi lähettää osoitteeseen: hr@ahdiagnostics.fi viimeistään 28.06.2019 mennessä.

Scientist in Microbiology – Evotec, Verona Area, Italy

https://www.linkedin.com/jobs/view/1283081895/?refId=3d7d4545-14be-43c7-8f4c-a58933feed15&trk=eml-vjr-similar-job-title&midToken=AQFgumZyIt6sOQ&trkEmail=eml-email_jobs_viewed_job_reminder_01-null-32-null-null-41f64x%7Ejwcdutfn%7E2y-null-jobs%7Eview

Aptuit, an Evotec COMPANY, is a worldwide Contract Research Organization, collaborating with all the major Pharma and Biotech companies in support of various drug discovery and development projects. To efficiently support on going activities and needs, we are looking for a

IV  Microbiology, Scientist                                                            

To efficiently support ongoing activities and needs, we are looking to a highly motivated person to join the Antibacterial Discovery Department, within the Evotec Infectious Disease Group. The ideal candidate should have a proactive and open attitude to work in a dynamic group.  

Reports to

• Group Leader
• Translational Microbiology  

Primary Responsibilities

• Be integral part of the Translational Microbiology group
• Capable for managing all the aspects characterizing and iv studies, study design, protocol generation and discussion, data analysis, report preparation and final discussion with the Client.
• Available for supporting in a matrix environment the structures in DD&D involved in the translational studies.
• Sufficient knowledge of applied microbiology required for manipulating bacterial pathogens.
• Willing to learn techniques specific for the antibacterial discovery and to support in required activities in case of specific need and workload.
• Manage in autonomy all the aspects linked to orders of lab material required for performing experimental activities Be the reference person for training in the area of expertise.
• Contribute to the finalisation of proposal (RFP) and support the request for information (RFI) process
• Maintains documentation and electronic data archives
• Preparing technical reports, scientific publications, and technical presentations for internal meetings
• Generate reports as necessary Interact with the Client as the technical expert.  

Required skills or attitudes  

• Bachelor Degree in Biology or Biotechnology or equivalent required. PhD. preferred
• At least 5 years of experience in the field of IV pharmacology, in the antibacterial discovery field preferred
• On hands experience in other therapeutic area e.g. respiratory, virology
• Flexible, energetic and a team player, able to navigate in a complex and very dynamic environment
• Lead gracefully under pressure.
• Active responder to challenges and to project dynamic changes
• Ability to multitask
• Positive attitude and sense of urgency
• Ability to learn from others and at the same time open to communicate, share and discuss.
• Good presentation and communication skills in English

If you are interested please send your CV  to  Rossana.schiaffini@aptuit.com by 15th of JUNE 2019 reporting the following subject: MICROBIOLOGY 2019

Application Development Scientist – Sartorius, Helsinki

https://www.linkedin.com/jobs/view/1287831966/?refId=3d7d4545-14be-43c7-8f4c-a58933feed15&trk=eml-vjr-similar-job-title&midToken=AQFgumZyIt6sOQ&trkEmail=eml-email_jobs_viewed_job_reminder_01-null-30-null-null-41f64x%7Ejwcdutfn%7E2y-null-jobs%7Eview

Application Development Scientist

Would you like to set new standards in a dynamic international environment by taking part in contributing innovative ideas? Are you a co-operative team player with a positive can-do attitude, a structured approach to work and a high level of commitment?

We are now looking for an enthusiastic Application Development Scientist with a passion for science, technology and innovation. This position is based in Helsinki, Finland and will report into the international Product Development structure headquartered in Göttingen, Germany.

What you can look forward to accomplishing:

– Independently design, conduct, and analyse experiments to support primarily the liquid handling and sample prep steps in various customer applications and workflows. Set up and establish respective lab processes.

– Work in the lab to generate data for products and to recommend customer process as well as product improvements

– Play a key role in future product innovation and roadmap by understanding the customer workflows and customer needs

– Communicate and collaborate effectively with colleagues to meet project goals

– Participate and present in regular group meetings and collaborate with the international development teams.

– Support writing of application notes, white papers and technical notes in collaboration with Marketing

– Visit customer sites, expos and scientific meetings to provide technical information around the use of products/processes

– Provide application support internally and externally (to Customers/R&D/Product Development, Sales, & Marketing) by assisting with technical queries and application trainings

Skills and experience that you need to bring to our company:

– Doctorate or Master’s Degree in Cellular Biology, Virology, Immunology or Biochemistry/Chemistry or a related area combined with minimum 3 years of relevant experience conducting research in laboratory in the Biopharmaceutical Industry

– Proven experience in the use of the following basic techniques such as ELISA, PCR, flow cytometry, cell imaging and cell culture 

– Proven scientific writing experience for articles and publications

– Knowledge in the area of development and validation of assays and GLP regulations

– Excellent documentation skills of protocols and results

– Strong customer focus

– Capability to run several projects in parallel

– Good communication and collaboration skills to support work in cross-functional teams

– Proactive personality and commitment to succeed in the given tasks

– Very good command of English (spoken and written), Finnish beneficial

– Willingness to travel globally and work for typically 1-4 week periods in other Sartorius locations based on project needs (mainly Europe)

We offer you:

– Interesting projects and a challenging full-time position in an international and growing laboratory and bioprocess technology business

– Flexible work environment and good benefits including extensive occupational healthcare services, flexible working hours, possibilities to remote work, supported lunch and well-being services

– To make Sartorius a great place to work we support our company values: openness, sustainability and enjoyment

For more information, please contact Hannes Jantunen, Head of Product Development at +358 40 7707267 on May 28th between 13:00-14:00 or June 6th between 10:00-11:00 or at firstname.lastname@sartorius.com

Does the position offered match your skill set? If yes, we look forward to receiving your job application in English (including your CV, salary request and the earliest date you can start working) by June 17th.

Research Scientist, Cell Biologist Metabolism – Hays, Stockholm, Sweden

https://www.linkedin.com/jobs/view/1284652296/?refId=3d7d4545-14be-43c7-8f4c-a58933feed15&trk=eml-vjr-similar-job-title&midToken=AQFgumZyIt6sOQ&trkEmail=eml-email_jobs_viewed_job_reminder_01-null-29-null-null-41f64x%7Ejwcdutfn%7E2y-null-jobs%7Eview

Research Scientist – Cell Biologist Metabolism

Hays specialist recruitment is now looking for a candidate to a 12 month assigment as a Research Scientist to our client AstraZeneca in Mölndal. The assigment is to start with a 12 months assigment with good chances  to extension and permanent employment.

Hays specialist recruitment is a global recruitment company that has been based in Sweden since 2003. Hays has a world wide network whitin the business areas and is passionated about people and your career. Would you like to read more about Hays visit our website www.Hays.se.

AstraZeneca is a major international healthcare business engaged in the research, development,

manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services.

AstraZeneca is proud to offer a unique workplace culture that inspires innovation and collaboration. Co-workers are empowered to express diverse perspectives – and are made to feel valued, energized and rewarded for their ideas and creativity.
The area

Your will be working within the CVMD iMed Bioscience department, which is a multi-discipline

department working with metabolic, cardiovascular and kidney diseases. The drug hunting activities also spans into many different modalities including small molecules, peptide and nucleotides.

This provides scientists with a unique opportunity for innovation in drug discovery.

You will be part of the metabolism in vitro group in Bioscience and focusing on questions within drug

discovery project in diabetes and NASH areas.

The Cell Biologist Metabolism supports drug discovery

projects with scientific input in the in vitro assay strategy and delivers key in vitro and ex vivo

decision-making data.
Major responsibilities:

• Independently apply existing in vitro and ex vivo assays for projects during different phase of

projects.

• Independently design and execute in vitro or ex vivo experiments

• Statistical analysis and interpretation of generated data

• Presentation of data at the team and project team level

• Document the work according to AstraZeneca standards, and prepare the preclinical

pharmacology part of regulatory documents as appropriate.

• Work collaboratively with in vivo, DMPK, etc scientists as required to ensure flow-scheme

connectivity and translatability between in vivo and in vitro models

• Work collaboratively within Bioscience and iMed to deliver on project key questions.

• Contribute proactively to a vibrant and innovative working environment where improvements

and new ideas are adopted and freely shared.

• Ensure compliance with corporate code of conduct guidance and other safety standards.
Minimum requirements

• Broad expertise in cell biology & biochemistry

• Experienced in establishing/performing cell-based assays.

• Cell culture, ELISA, western blot, and qPCR experience is a must

• Experience with primary cell culture, measurements of cellular respiration, and knowledge of

adipose and liver cell biology is an additional advantage.
Looking forward to see your application!

Postdoc Positions Available – Augmented Exosomes for Cardiac Repair, AstraZeneca, Sweden

https://job-search.astrazeneca.com/job/gothenburg/postdoc-fellow-augmented-exosomes-for-cardiac-repair/7684/12059369

Location: Gothenburg, Västra Götaland County, Sweden Job reference: R-046184
Posted date: May. 31, 2019
Apply

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. We’re proud to have a unique workplace culture that inspires innovation and collaboration. We believe in the potential of our people and you’ll develop beyond what you thought possible.

The new R&D Oncology organisation brings together early and late oncology teams, from discovery through to late-stage development, with oncology specific Regulatory and Biometrics groups.

You’ll be in a global pharmaceutical environment but also exposed to strong rigorous academic science. For example, every postdoc has an external academic mentor to ensure we are working and publishing at the highest level in a field. What’s more, you’ll have the support of a leading academic advisor, who’ll provide you with the guidance and knowledge you need to develop your career.

Our Discovery Sciences team operates from truly state-of-the-art centres spanning the UK, US and Sweden. You’ll work with some of the most knowledgeable technological experts in the industry, all collaborating on high-profile drug discovery projects.

Extracellular vesicles represent an exciting opportunity for delivery of complex RNA-based drugs, and since 2015 we have been working with a team of postdocs on developing new technologies for drug loading, targeting and functional delivery using extracellular vesicles. We now have openings for three new postdocs working on 1) delivery of mRNA, 2) targeting to heart, and 3) developing innovative in vitro and in vivo models of heart disease to explore the action and underlying biological mechanisms of engineered extracellular vesicles in a therapeutic setting. The internal postdoc work at AstraZeneca is supported through collaborations with leading academic experts.

Myocardial infarction (MI) results in severe damage to the heart muscle tissue with scar formation and irreversible loss of cardiac function leading to the development of heart failure. Encouraging results have been achieved with cell therapy to regenerate the heart tissue and improve function, but there is accumulating evidence that these beneficial effects are mainly mediated by extracellular vesicles. We propose to study the action of engineered extracellular vesicles from human IPS-CPCs (cardiac progenitor cells) and from adult stem cells in vitro (angiogenesis, cardiomyocyte proliferation, apoptosis) and in rodent models of MI in vivo. We will engineer extracellular vesicles to carry additional (known and novel) stimulatory factors to augment their biological activity (e.g. VEGF-A, mRNA coding for genes driving proliferation, etc.). We have developed novel cell-based and in vitro technologies for EV loading with proteins and RNA, which will be exploited in this project (focus for postdoc-1). We will explore targeting of extracellular vesicles to heart tissue (focus for postdoc-2) with known and novel ligands and examine improved drug exposure to heart tissue. We will multiplex in vivo experiments with extracellular vesicles by bar-coding technology for bio-distribution studies. In addition, we have a separate recruitment ongoing in CVRM for a 3rd AZ postdoc working on the development of novel in vitro and in vivo regenerative models of heart disease. The three postdocs will work closely together on the shared goal of developing novel opportunities around the use of engineered extracellular vesicles for therapeutic treatment of heart disease. As a postdoc you will also get the opportunity to try novel techniques and ideas. We will also support development of leadership skills and deeper understanding of drug development process.

Education and Experience required:

Essential:

• A PhD in biological sciences with a strong cell biology or biochemical focus.
• A strong scientific track record, as evidenced by published papers in high quality peer-reviewed journals.
• Excellent organizational, communication and interpersonal skills, combined with the ability to work collaboratively across boundaries and problem solve in the absence of complete information.
• Entrepreneurial ways of working

Desirable:

• Experience of cell imaging, confocal microscopy, FACS and RT-PCR
• Experience with in vivo experiments and bio-distribution
• Experience with EV drug loading (postdoc-1) and/or drug targeting (postdoc-2)

Skills and Capabilities required:

• Working experience of isolation, characterization and manipulation of extracellular vesicles.
• Excellent expertise with mammalian cell culture including iPSC and adult stem cells, general molecular biology techniques, RNA biology, and protein engineering.
• Experience working with proteomics and transcriptomics data
• Strong oral and written communication skills

This is a 3 year programme.  2 years will be a Fixed Term Contract, with a 1-year extension which will be merit based. There are 2 vacancies for engineering of extracellular vesicles (e.g. postdoc-1 and -2). The roles will be based in Gothenburg, SE, with a competitive salary on offer. To apply for this position, please click the apply link below.

Advert opening date – 31st May 2019 / Advert closing date – 9th August 2019

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.