The labs of Siobhan Brady (Dept. of Plant Biology and Genome Center) and David
Segal (Dept.
of Biochemistry and Molecular Medicine, School of Medicine, Genome
Center) at the University of California, Davis are recruiting a
postdoctoral scholar, starting immediately.
In this project, funded by the USDA and the BBSRC, the postdoctoral
scholar will use synthetic biology to create targeted mutations in
promoters of genes involved in regulation of nitrogen metabolism in both
Arabidopsis and tomato. In addition, the postdoctoral
scholar will engineer readers and writers associated with epigenetic
modification of DNA in order to silence gene expression within the
context of a metabolic regulatory logic.
Salary: Commensurate with qualifications, experience, and prevailing salary scale.
Application deadline – February 15, 2019 or until filled.
Qualifications
Required
· PhD in Molecular Biology, Genetics, Plant Biology or related
field
· Extensive experience with molecular biology and cloning
· Experience with CRISPR-Cas9
· A strong publication record
· Excellent writing and communication skills
· Ability to work independently and to work well with others
· Ability to work on an international interdisciplinary team
Recommended
· Experience with plant transformation
· Experience with programming (R, Python or other)
· Experience with statistical analyses
How To Apply
Cover Letter describing relevant experience and interests, CV, and contact information for 3 references to sbrady@ucdavis.edu
Post-doctoral and pre-doctoral scientist for research project linked to Natural Killer cell
therapy in the Finnish Red Cross Blood Service, Helsinki, Finland
Finnish
Red Cross Blood Service is a non-profit organisation responsible for
collecting blood and supplying blood
products all over Finland in a centralised manner, with the annual
turnover of about 65 million €. The FRC Blood Service provides all
histocompatibility testing for clinical transplantation in Finland and
has active programs in cell therapy; for example, it
has produced therapeutic MSC-cells to over 60 patients. We have a
research budget of over 3 million €, with the focus areas in cell
therapies, blood donors and genomics of transplantation. Over 60 PhD
theses have been completed in the Blood Service and every
year 20-30 peer reviewed scientific papers are published by our
scientists.
Finnish
Red Cross Blood Service, together with University hospitals of Helsinki
and Turku, has started a project aiming to Natural Killer (NK) cell
therapy for e.g. relapse of malignant diseases after
stem cell transplantation. We are now looking for a post-doctoral
scientist and pre-doctoral scientist to a research project supporting
the therapy approach. The primary goals are related to identification of
preferential patient groups for NK therapy and molecular
characterization of NK cell product.
We
assume good skills in immune cells and data-analysis. The positions can
be fulfilled immediately and are primarily funded by the state
VTR-funding and by the Cancer Foundation (Syöpäsäätiö). Post-doctoral
position will be initially for two years and pre-doctoral for one year
and may be extended depending on funding.
Tehtäväsi on diagnostiikkatuotteidemme myynti ja tuotetuki. Sinulla
on avainasiakasvastuu (KAM), jossa teet yhteistyötä muiden
spesialistiemme kanssa. Odotamme luonnontieteellisen (FM) tai
laboratorioalan koulutuksen lisäksi myyntihenkisyyttä ja -kokemusta ja
valmiutta kotimaan matkapäiviin.
Tarjoamme erinomaiset tuotteet, hyvän tuotekoulutuksen myös tehtailla
sekä mukavaksi tunnetun työyhteisön tuen kilpailukykyisin eduin.
Lähetä vapaamuotoinen CV ja vapaamuotoinen hakemus palkkatoiveineen 11.2.2019 mennessä osoitteella hakemukset.turku@pomona.fi
Annan mielelläni lisätietoja!
Jarmo Laakkonen, Toimitusjohtaja
Parhaiten tavoitat minut 28.1. klo 13-15.00 tai 7.2. klo 13-15.00
Mikroskopian (Leica Microsystems)
myyjänä tarjoat ratkaisuja mm. teollisuuteen, viranomaisille
(rajavartiosto ja KRP), kouluihin, museoille jne. Olet innokas
paneutumaan asiakkaidemme tarpeisiin ja myös tekemään tulosta. Tiedät
kokemuksesta, mitä myyntityö on ja koet sen omaksesi. Koulutuksesi on
todennäköisesti tekninen (ins, AMK-ins tai DI).
Tarjoamme erinomaiset tuotteet, hyvän tuotekoulutuksen myös tehtailla
sekä mukavaksi tunnetun työyhteisön tuen kilpailukykyisin eduin.
Lähetä vapaamuotoinen CV ja vapaamuotoinen hakemus palkkatoiveineen 11.2.2019 mennessä osoitteella hakemukset.turku@pomona.fi
Annan mielelläni lisätietoja!
Pekka Sulonen, Myyntipäällikkö
Parhaiten tavoitat minut 29.1. tai 30.1. klo 13-16.00, puh. 040 543 2317
Post-doctoral; 24 months (starting in March/April 2019), Strasbourg, France
Title: New targets and pathways in neuroprotection.
PROJECT:
The project aims at identifying mechanisms of neurodegeneration with
the main focus on small bioactive molecules, which deficits were
observed during aging and further exacerbated in several
neurodegenerative diseases including Alzheimer or Parkinson disease.
Such bioactive molecules may act as ligands for transcription factors
and are important for adaptive reprogramming of the organism,
but their study is impeded due to lack of appropriate tools. We propose
to use newly developed bioprobes to visualize such molecules and study
their intracellular traffic between cellular organelles and its
relevance for cell physiology and pathology. The same
tools will be also employed to study blood-brain-barrier transfer and
inter-cellular traffic of such molecules as mechanisms underlying
adaptive processes and activity-dependent cellular communication.
Studies will be carried out in mouse brain tissue preparations,
organotypic and primary cell cultures using in vivo imaging and if
necessary high-resolution imaging. Particular attention will go to
neuron-neuron and neuron-astrocyte-microglia circuits.
We
are looking for highly motivated post-doctoral fellow, with good
English level and background in cellular biology and cellular
communication.
Sound experience in confocal imaging is required, whereas knowledge of
life imaging techniques will be useful. Similarly, good knowledge of
primary or cell culture techniques is necessary whereas experience with
organotypic cultures will be useful. Although
any technical expertise in molecular biology can be acquired in the
team, any previous experience in these techniques will be of benefit.
The candidate should be willing to bring personal input to the
challenging multidisciplinary project, write scientific
papers, contribute to preparation of research grants and participate in
animating team’s life. The project will be carried out at IGBMC,
Strasbourg, which lies in heart of dynamic tri-national region of Alsace
and will benefit from proximity and collaborations
with research teams in Basel and Freiburg.
Applicants
should submit their complete application file (CV, motivation letter,
publication list and contact to at least two reference scientists
in one PDF file) by email.
Contact information:
Dr Wojciech Krezel (Research Director at INSERM)
IGBMC, 1, rue L.Fries, 67404 Illkirch (CU Strasbourg), France
Post-doctoral; 24 months (starting in March/April 2019), Strasbourg, France
Title: Role of retinoid signaling in the physiology and pathology of basal ganglia
The project:
Several
lines of evidence indicate that retinoid signaling, best known for its
developmental functions, is also critical for homeostasis and
neuroprotection of adult nervous system. In particular, abnormal
signaling of some retinoid receptors is associated with Huntington or
Parkinson diseases and may contribute to their physiopathology whereas
point mutations of such receptor(s) are causal factors
of rare neurological disorders. The project aims at characterizing the
mechanisms through which deficient or excessive retinoid signaling may
contribute to neurodegeneration. The project will take advantage of
classical and new genetic mouse models of neurodegenerative
diseases and will involve genomic and functional studies in primary
organotypic or neural cell cultures as well as in vivo analyses
in mice with final objective to propose new therapeutic targets and
strategies of treatment. The project will be carried
out at IGBMC (Strasbourg-Illkirch), an international research institute
located in the heart of dynamic research region at crossroads of France,
Germany and Switzerland. It will benefit from state-of-the-art
infrastructure and international collaborations which
include world clinical experts in neurology.
We
are looking for highly motivated post-doctoral fellow with solid
research experience in molecular and cellular neurobiology (experience
in primary mammalian cell and/or organotypic cultures will be very
useful). Experience in mitochondrial biology and calcium signaling will
be of great asset. The ability to work in an English speaking team and
good communication skills are required. The ideal
candidate should be able to bring original input to the 2 year
challenging project, write papers and projects, and participate in
animating team’s life.
Applicants
should submit their complete application file (CV, motivation letter,
publication list and contact to at least two reference scientists)
in one PDF file by email.
Contact information:
Dr Wojciech Krezel (Research Director at INSERM)
IGBMC, 1, rue L.Fries, 67404 Illkirch (CU Strasbourg), France
Meitä Orionilaisia on 3200 yli 20 maassa ja työskentelemme
hyvinkin erilaisissa tehtävissä. Joukostamme löytyy niin tutkijoita ja
laborantteja kuin insinöörejä ja IT-asiantuntijoitakin sekä
tuotantotyöntekijöitä ja monia muita. Tarjoamme työntekijöillemme
monipuolisia sekä vastuullisia tehtäviä aidosti monialaisessa
ympäristössä. Kannustamme oman osaamisen kehittämiseen ja tarjoamme
mahdollisuuden vaikuttaa työtehtäviin ja oman urapolun luomiseen
Orionilla. Me etsimme oman alansa huipputekijöitä, jotka jakavat aidon
innostuksemme siihen, mitä teemme. Tutustu Orioniin tarkemmin >>
Haemme laboratorioassistenttia määräaikaiseen
työsuhteeseen Molecular Profiling -yksikköön. Molecular Profiling
-yksikkö vastaa Orionilla kehitettävien pienmolekyylien ja biologisten
lääkeaineiden teho-, turvallisuus-, metabolia ja
formulaatioseulonnasta.
Tehtäviisi kuuluu nisäkässoluviljelmien ylläpito,
nisäkässolujen valmistelu ja maljaus seulontatesteihin, nisäkässolujen
tai kudosnäytteiden altistus testattaville aineille ja testien analyysit
mittalaiteilla. Tehtävään valittavan henkilön tulee myös pystyä
valmistelemaan mittalaitedata ja tehdä alustava analyysi tulosten laadun
tarkkailua varten.
Tehtävässä menestyminen edellyttää käytännön kokemusta:
Nisäkässoluviljelystä (suspensio- sekä adherentit solut)
384- ja 96-kuoppalevyillä tehtävistä in vitro seulonnoista
Aseptisesta työskentelystä
Kuoppalevylukijoiden käytöstä
Kokemus Hamilton nesteenkäsittelyrobottien tai vastaavan automatiikan käytöstä katsotaan eduksi
Lisäksi kokemus FLIPR-tetra mittalaitteen käytöstä katsotaan eduksi.
Arvostamme myös kokemusta entsymaattisista in vitro menetelmistä ja MS Office –ohjelmien, kuten Excel ja Word, hallintaa.
Lisätietoja tehtävästä saat Mikko Karjalaiselta numerosta 0104265849 seuraavina aikoina:
16.1. klo 14-15
18.1. klo 13-14
22.1. klo 13-14
25.1. klo 10-11Tehtävään valitulta henkilöltä edellytetään hyväksyttyä terveystarkastusta, joka sisältää myös huumausainetestauksen.P
A
post-doctoral position in the Pravetoni lab at the University of
Minnesota Medical School is available immediately
for individuals interested in development of immunotherapies to reduce
opioid use disorders and opioid-related overdoses. Our unique
multidisciplinary research program integrates rational vaccine design,
immunomodulators, formulation/delivery platforms, pre-clinical
models, analysis of B and T cell lymphocyte repertoire, GLP/GMP studies
to support regulatory approval and clinical evaluation, and ad hoc
industry collaborations.
Our
team is currently planning Phase I clinical trials of vaccines
targeting heroin and oxycodone. Strategies and platforms
will be applied to development of vaccines or antibodies against
emerging pathogens, and agents of bioterrorism or chemical warfare.
We are seeking an independent and motivated colleague interested in leading multidisciplinary projects as well as team
efforts. For our recent publications search PubMed for “Pravetoni M”. Posting can be found at: https://hr.myu.umn.edu/jobs/ext/328252.
Our international multidisciplinary research group (https://www.btk.fi/research/molecular-systems-immunology/)
led by Academy Professor Riitta Lahesmaa is based at Turku Centre for
Biotechnology (the Centre), BioCity Turku, Turku, Finland. We are
seeking for a motivated postdoctoral researcher or project researcher
with possibility to continue work as a doctoral candidate.
Disorders
in immune system and lymphocyte function lead to inflammatory diseases
e.g. rheumatoid arthritis and Type
1 Diabetes. Project will focus on studying the molecular mechanisms
underlying immune mediated diseases aiming at enabling individualized
treatment in the future.
Description of recruiting organization
Molecular
Systems Immunology group aims at understanding the regulation of human
immune system to predict, prevent
and treat immune mediated disorders. We study epigenetic and
transcriptional regulation of T cells and molecular mechanisms of immune
mediated diseases.
Turku
Centre for Biotechnology is a joint research institute of University of
Turku and Åbo Akademi University.
The mission of the Centre is to promote high quality research and
training. The Centre has excellent state-of-the-art technology platforms
and expertise in single-cell omics, next-generation sequencing,
epigenomics, proteomics, computational biology and high-end
cell imaging.
Project
The
project aims at understanding how novel regulators of immune system,
recently discovered by our group,
act on a molecular level. We will use cutting-edge single-cell omics
tools, i.e. single cell sequencing and mass cytometry. We will
collaborate closely with Dr. Tapio Lönnberg, an in-depth expert in
single-cell omics and head of our Centre’s single-cell omics
facility. Our key collaborator is Research Director Laura Elo and her
group, the Medical Bioinformatics Centre, who have developed novel tools
to analyses single-cell omics data.
Qualifications, successful candidates have:
A relevant doctor’s degree (postdoctoral researcher) or a relevant master’s degree (project researcher) e.g. in
life sciences or in biomedicine
High level of motivation, self-initiative and independency
Excellent team work and communication skills in English (both oral and written)
First-rate molecular and cell biology knowledge and skills
Strong publication record in international journals (postdoctoral researcher) at least in one of the following areas:
immunology, molecular and cellular biology, autoimmunity, genetics, epigenetics.
Application
The
salary is in accordance with the University salary system (for teaching
and research personnel) level 5 (postdoctoral
researcher) where the work specific salary component is 2 903,61 €/month
or levels 3-4 (project researcher), where the work specific salary
component is 2 209,17 – 2507,62 €/month. In addition, there is a share
increase based on the personal performance,
which is, at most, 50% of the base salary. The position starts at
earliest on March 1st, 2019 (or as agreed). The positions are initially
for two years, one optional year possible. There is a trial period of
six months.
Please include a CV, full publication list, list of selected publications and contact information for three references
in your application.
For further information on the positions please contact: Prof. Riitta Lahesmaa, e-mail: riitta.lahesmaa@btk.fi
. Enquiries on the application procedure may be directed to Human Resources Specialist Paula Luoma, paula.luoma@utu.fi .
Kuopio Center
for Gene and Cell Therapy (KCT) is a world-renowned research institute
located in Kuopio, Finland. Our mission is to conduct high-level
research on basic and translational fields of gene- and cell therapy.
The centre’s niche is in the interface between academic, basic research
and the commercial biotechnology industry. KCT provides an exciting
environment for applied research, discovering, establishing and
developing them through Phase I clinical trials and utilizing some of
the most advanced analytical and mechanistic proof-of-principle
approaches in the sector.
Now we are
seeking for an efficient manager to coordinate our in vivo studies to
support the development of investigational gene- and cell therapies. The
successful candidate will be responsible for designing, implementing
and overseeing of animal studies including pathology, histology and
molecular analytics. The candidate must have a strong in vivo
pharmacology experience. This person will work closely together with
internal project teams and external collaborators and therefore have
excellent communication skills.
Main responsibilities
Design and manage in vivo experiments for gene- and cell therapy pharmacodynamics, pharmacokinetic and efficacy studies.
Follow the field of experimental animal science and applicable technologies
Work in close collaboration with research teams and animal facility personnel.
Analyze data, interpret results and design subsequent studies.
Present and document research plans, results and apply for necessary project licenses and authorizations.
Requirements:
MSc with several years’ experience or PhD from applicable field
Strong experience with in vivo animal experimental models
Excellent oral and written communication skills in English
Must be able to multitask and collaborate in multidisciplinary environment
Strong motivation, flexibility and ability to troubleshoot
We
offer young and dynamic working environment. Possibility for career
development in a growing international research center. Be part of our
future success!
More information Cell Therapy Unit Director Tuija Kekarainen tel. 040-5376603, phone calls 15th Jan at 12-14 (Tuija.kekarainen@kct.fi) and HR Director Johanna Pirinen (Johanna.pirinen@kct.fi).
The Neuroscience (NS) Department at Novartis Institutes for Biomedical Research (NIBR) in Basel, Switzerland, is seeking a Scientist with Molecular and Cell Biology skills to join a lab focusing on neuroscience. The specific focus of the team is to modulate neuroinflammation to ameliorate or halt pathology in neurodegenerative diseases.
As part of a multidisciplinary, highly collaborative team, you will independently plan, execute and analyse experiments and interpret data aiming at the discovery of new therapeutic targets and drug leads. The group is using complex primary cell culture models, but also establishing cellular high and medium throughput assays to assess therapeutic efficacy of antisense oligonucleotides, antibodies or low molecular weight compounds under relevant physiological conditions. On top of a solid neurobiological background, good knowledge of and experience with immunological methods would be an asset.
You will present data in meetings within the department and contribute to writing of research documents and publications. Furthermore, you will interact with multiple groups within our department as well as with other groups and external colleagues and have the opportunity to represent the lab in project team meetings.
Minimum Requirements
Master’s degree in Molecular Biology, Biochemistry, Biotechnology or another relevant Life Science discipline
Several years of post-graduate experience in industry or academia in drug discovery or related laboratory research
Proficiency in Molecular and Cell Biology techniques, comprising but
not restricted to cultivation and manipulation of cell lines and primary
cell cultures, biochemical assays (e.g. recombinant DNA technologies,
cytokine assays, second messenger assays, ELISA, signaling assays,
western blot) and high content cellular imaging technologies
Excellent understanding of pathway biology and experience in solving drug discovery related biological questions
Proven experience with complex cellular models, in particular with ES
cells and or iPS cells and confocal microscopy is advantageous
Highly motivated team player with refined collaboration skills
Excellent communication and interpersonal skills
Fluency in English (oral/written)
Division NIBR Business Unit NEUROSCIENCE Country Switzerland Work Location Basel
Company/Legal Entity
Novartis Pharma AG Functional Area Research & Development Job Type Full Time Employment Type Regular
