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A PhD student position is available in the research group of Dr Arto Pulliainen at the Institute of Biomedicine, University of Turku

5.7.2017 | Ajankohtaista
Pulliainen-laboratory aims to understand i) how bacterial toxins/effector proteins are secreted, ii) how bacterial toxins/effector proteins recognize and enter the target host cell and iii) how bacterialtoxins/effector proteins manipulate host cell signaling to ultimately influence the disease progression. Our ultimate goal is to gain insights that allow development of new antimicrobials for emerging antibiotic resistant bacteria. The laboratory is currently funded by the Academy of Finland and the Sigrid Jusélius Foundation (– 2020).
 
The research focus for the PhD student position is on type IV secretion systems (T4SSs) – multiprotein megadalton complexes that span the cell envelope of clinically significant bacteria including generaBrucella, Helicobacter, Legionella, Bartonella and Bordetella. T4SSs translocate a multitude of different toxins/effector proteins, such as pertussis toxin or CagA oncoprotein, into to the extracellular space or directly into the cytosol of host cells. Type IV secretion systems also mediate bacterial conjugation and therefore they are key players in the spread of antibiotic resistance determinants.
 
The person selected for the position studies the secretion mechanism of T4SSs as well as the elusive host cell recognition process of T4SS pilus structures. The project also involves drug discovery approaches. T4SSs are ideal drug targets since no analogous counterparts are known from eukaryotes. 
 
To qualify for the position, the candidate needs: 1) high motivation level, work morale and independent initiative, and 2) completed or nearly completed MSc or an equivalent degree.
 
Please send your application in English as a single PDF document to Arto Pulliainen (arto.pulliainen@utu.fi ), 31.8.2017 at the latest. The application has to contain: i) one page motivation letter, and ii)CV with contact information of at least two references. 
 
The start time is negotiable, but September 2017 is preferable. The position includes a 4-month trial period.
 
Further information:
Arto Pulliainen, PhD, Docent/Adjunct professor
Institute of Biomedicine
University of Turku
Kiinamyllynkatu 10
FI-20520 TURKU
https://www.utu.fi/en/units/med/units/immunology/research/Pages/pulliainen.aspx  
https://twitter.com/artopulliainen   
tel. +358 40 1586044
arto.pulliainen@utu.fi

Post-Doctoral Fellow at Harvard in Bioengineering, Hematopoietic Stem Cell Biology and Blood Disorders: Boston, MA, United States

4.7.2017 | Ajankohtaista
Two postdoctoral fellow positions are available in the Dhvanit Shah Laboratory (www.shahlaboratory.org) at the Division of Hematology, Brigham and Women’s Hospital (BWH) & Harvard Medical School (HMS), Boston MA, United States.
 
The Shah laboratory is located in a dynamic Harvard Medical Area that offers excellent opportunities for intellectual exchange and collaborations among investigators from diverse fields. We investigate the origin, development, and differentiation of hematopoietic stem cells (HSCs), and their utility in treating patients with blood and bone-marrow diseases. We have expertise in utilizing zebrafish, mice, and human induced pluripotent stem (iPS) cells to analyze novel genes and mechanisms important for blood formation. Our goals are to utilize our knowledge in developing cellular- and mechanism-based therapies as well as generating functional HSCs for the treatment of hematological diseases.
 
Position # 1: Hematopoietic Stem Cell Development and Disorders
Ideal candidate will have Ph.D., M.D., or M.D./Ph.D. in Regenerative Medicine, Stem Cells, Immunotherapy, Hematology, Oncology, and/or Biology. This position offers an excellent opportunity to learn and apply skills in directed differentiation of mouse embryonic stem cells and/or human induced pluripotent stem cells, epigenetics, HSC transplant, xenograft, computational biology, high-throughput screening, gene-editing, and/or molecular and cellular biology techniques. Strong background in one or more of these areas is preferred. Qualified candidate should be able to work independently as well as in a group environment.
 
Position # 2: Bioengineering of 3D Scaffold Development
Ideal candidate will have Ph.D., M.D., or M.D./Ph.D. in Tissue Engineering, Biomaterials, Biophysics, Machine Learning, Systems Biology, Chemical Engineering, and/or Drug Development. This position offers an excellent opportunity to learn and apply skills in organoid development, 3D bio-printing, Bio-MEMS, artificial intelligence, microfluidics, proteomics, and/or medicinal chemistry. Strong background in one or more of these areas is preferred. Qualified candidate should be able to work independently as well as in a group environment.
 
Interested candidates should send their cover letter, CV, and contact details of three references to:
 
Dr. Dhvanit I. Shah
Division of Hematology,
Brigham and Women’s Hospital &
Harvard Medical School
One Blackfan Circle, Karp 06.211
Boston, MA 02115
dshahlab@gmail.com
 
BWH & HMS are an affirmative action/equal opportunity employers. 

Open research positions at the University of Tampere

3.7.2017 | Ajankohtaista
 
 
 
 
 
 
 

Post doc position at the Department of Biosciences, University of Helsinki, Finland

3.7.2017 | Ajankohtaista

Post doc position is available at the Laboratory of Neurotherapeutics located at the Department of Biosciences, Division of Physiology and Neuroscience, University of Helsinki. The research group investigates the underlying neurobiological mechanisms and predictive (bio)markers of rapid-acting antidepressants using in vivo pharmacological tools, biological screenings (e.g. quantitative phosphoproteomics), pharmaco-EEG (electroencephalogram) and behavioural tests.

We are looking for an enthusiastic, highly motivated person with a PhD in neuroscience, pharmacology or molecular neurobiology. The candidate must be able to perform basic neurobiological, pharmacological (in vivo) and behavioral methods and animal surgeries. Previous experience with in vivo EEG recordings, animal behavior, and curriculum of education in laboratory animal science are considered very beneficial. The successful candidate should also have strong communication skills in English and be well organized. Selected candidate will also supervise undergraduate and graduate students in the lab. Salary will be based on the University salary system for teaching and research personnel, and composed of both task related and personal performance components. The position will be initially for 1 year but could be potentially extended. The position will start 1st September 2017.

We offer a great opportunity to work in extremely interesting research project in a dynamic and international environment. More information of our research can be found at our website http://www.helsinki.fi/biosciences/physiology/rantamaki.htm or through e-mail tomi.rantamaki[at]helsinki.fi.

To apply, please send the following documents as a SINGLE PDF DOCUMENT to tomi.rantamaki(at)helsinki.fi. The deadline for the application is 21st of July 2017.

Only individuals invited to an interview will be contacted.
• Cover letter (incl. statement of research interest and skills relevant for the position)
• CV (max. 3 pages; single-paced, 10 ppt. Times New Roman),
• Publication list (single-paced, 10 ppt. Times New Roman)
• Two recommendation letters (max 1 page)

Contact information:
Dr. Tomi Rantamäki
Laboratory of Neurotherapeutics
Department of Biosciences, Division of Physiology and Neuroscience
P.O.Box 65 (Viikinkaari 1)
00014 University of Helsinki
Helsinki, Finland
Mobile: +358-415020978
E-mail: tomi.rantamaki[at]helsinki.fi
http://www.helsinki.fi/biosciences/physiology/rantamaki.htm

The call for 12 Doctoral Student (Early Stage Researcher) positions in GenomMed doctoral programme is now open at the University of Eastern Finland

3.7.2017 | Ajankohtaista
The call for 12 Doctoral Student (Early Stage Researcher) positions in GenomMed doctoral programme is now open!

The GenomMed programme will train international experts in translational genomics aiming to solve health care -related questions in the fields of cardiovascular and metabolic diseases and neurosciences to create solutions and innovations to support development of novel treatments and enhance treatment of patients in the European and global environment.

Translational genomics and mechanics training programme focuses on
  1. basic genomics research of major common diseases
  2. molecular research cardiovascular and metabolic diseases andneurosciences
  3. translational research aiming atclinical adaptation of research results

Twelve (12) Early Stage Researchers (ESRs) will be recruited for four-year PhD study program from the beginning of 2018.

We are looking for candidates who
    • are enthusiastic and highly motivated
    • are aiming to build a career in the fields of genomics and translational medicine
    • have completed a suitable higher university degree (MSc or equivalent in a relevant field)
    • obtained excellent academic results in the past
    • are fluent in English

Application deadline is 21st July 2017, 23:59 Finnish time (EEST, UTC/GMT +3 hours)
More information: www.uef.fi/genommed
Any questions? For further information on research, supervision, application procedure, please contact genommed@uef.fi

Post-doctoral positions in the field of evolutionary and developmental skin genetics (U Penn)

27.6.2017 | Ajankohtaista
Kamberov Laboratory, Department of Genetics in the Perelman School of Medicine at the University of Pennsylvania, USA.

Post-doctoral positions are available in the field of evolutionary and developmental skin genetics.

Our lab’s research focuses on unraveling the developmental networks and genetic changes that underlie the divergence of humans from other species and for the diversity of present-day human populations. We are broadly interested in evolution of humans, but the core focus of the lab is on the skin and its appendages. We pursue these goals in order to not only understand the genetic origins of human specialization and variation but also seek to apply our findings to the betterment of human health. Available projects include: dissection of genetic pathways of skin appendage development and regeneration in mouse models; discovery and modeling of human adaptive variants using transgenic mice; high throughput screening for genetic elements controlling the development and uniqueness of human skin appendages.

A doctorate in biology or related field is required. Applicants with a strong background in genetics/genomics, developmental biology and molecular biology are encouraged to apply.

Interested candidates should provide: 1) your CV 2) A brief letter detailing your interest in the lab and relevant past research experience 3) The contact information for three references who can comment on your research. Application materials and any questions regarding the position should be sent to Yana Kamberov: yana2@mail.med.upenn.edu

References:
Kamberov, Y. G., Wang, S., Tan, J., Gerbault, P., Wark, A., Tan, L., Yang, Y., Li, S., Tang, K., Chen, H., Powell, A., Itan, Y., Fuller, D., Lohmueller, J., Mao, J., Schachar, A., Paymer, M., Hostetter, E., Byrne, E., Burnett, M., McMahon, A. P., Thomas, M. G., Lieberman, D. E., Jin, L., Tabin, C. J., Morgan, B. A., Sabeti, P. C.: Modeling recent human evolution in mice by expression of a selected EDAR variant. Cell 152(4): 691-702, 2013.
Kamberov, Y. G., Karlsson, E. K., Kamberova, G. L., Lieberman, D. E., Sabeti, P. C., Morgan, B. A., Tabin, C. J.: A genetic basis of variation in eccrine sweat gland and hair follicle density. Proc Natl Acad Sci USA 112(32): 9932-7, 2015.

Lab Website:
www.kamberovlab.com