Ajankohtaista

Indiana University School of Medicine-Stark Neurosciences Research Institute-Associate Professor or Professor position available

21.8.2017 | Ajankohtaista
The Department of Psychiatry at Indiana University School of Medicine, in conjunction with the Stark Neurosciences Research Institute, is seeking to fill an immediate opening for a full-time tenure track position at the level of Associate Professor or Professor.

Candidates should possess a doctoral degree in psychology, psychiatry, neuroscience, or a related field and have established research credentials in the area of neural mechanisms underlying alcohol and/or drug addiction, including nicotine, cannabinoids, opiates or psychostimulants. Responsibilities will include: developing and sustaining an independent research program that will complement present on-going basic and translational research activities, and providing a foundation for better integration of research activities among current investigators, with the overall goal of enhancing our understanding of neurobehavioral and genetic mechanisms underlying alcohol and drug abuse and translating these findings to benefit patients.

Research space will be in the new Neurosciences Building; investigators in this building have access to state-of-the-art Core Facilities. Other responsibilities will include participation on department committees and teaching of residents, interns, medical students and graduate students.  The department and the university place a high priority on creating a diverse learning environment and on supporting the professional development of ethnic minorities, women, and people with disabilities. Applications are encouraged from professionals of all ethnic backgrounds.

Located in Indianapolis, Indiana University School of Medicine is the second largest medical school in the United States, with a student body that includes over 46% women and 7% ethnic minorities.  Indianapolis is the 13th largest city in the United States and is a growing, diverse city with a rich cultural heritage. In addition to having active sports, cultural, arts and educational events and programs, Indianapolis is located centrally near several other major cities, including Chicago, Louisville, Cincinnati and Columbus. 

Interested applicants should send their curriculum vitae and statement of research experience and interests to majhughe@iupui.edu  (Attn: William J. McBride, Ph.D.,). 
Applications will be accepted until this position is filled.  The departmental website is located at http://www.iupui.edu/~psych/ .  Indiana University School of Medicine is an Equal Opportunity Employer/Affirmative Action, M/F/D.

Two postdoctoral fellow positions are available at Mount Sinai School of Medicine

21.8.2017 | Ajankohtaista
Two postdoctoral fellow positions are available at Mount Sinai School of Medicine, Department of Neuroscience, in New York.

1)      Studies of epigenetic mechanisms of chronic pain. 
The project involves the use of advanced transgenic mouse models, biochemical and genomic methods, for the study of brain region-specific adaptations associated with nociceptive sensitization and/or chronic pain induced mood disorders.  Applicants must have a PhD degree in the Neuroscience or Molecular Biology.  Experience in molecular biology/biochemistry is highly preferred.  Other desired skills include experience in mouse behavior, small animal surgery or electrophysiology.
2)      Studies on addiction vulnerability under chronic pain states. 
The project involves the use of transgenic mouse models, live imaging and brain biochemistry to understand the mechanisms underlying the actions of opioids under chronic pain states. Experience in small animal surgery and mouse behavior is highly preferred.

Interested Individuals should send a short letter of interest, a CV and include contact information for at least 3 references to: venetia.zachariou@mssm.edu

FIMM is currently seeking Research Coordinator for High Throughput Screening Operations

14.8.2017 | Ajankohtaista
The Institute for Molecular Medicine Finland (FIMM) is an international research institute focusing on human genomics and personalised medicine at the University of Helsinki. In the beginning of 2017 FIMM joined the University of Helsinki’s new life science research centre, Helsinki Institute of Life Science HiLIFE, as an operational unit. FIMM integrates molecular medicine research, technology centre and biobanking infrastructures under one roof, promoting translational research in grand challenge projects, specifically, the impact of genome information from the Finnish population in personalised health and medicine, individualised cancer medicine, and digital molecular medicine. FIMM is part of the Nordic EMBL Partnership for Molecular Medicine, composed of the European Molecular Biology Laboratory (EMBL) and the centres for molecular medicine in Norway, Sweden and Denmark, and the EU-LIFE Community.
 
FIMM is currently seeking Research Coordinator for High Throughput Screening Operations
 
Description:
The High Throughput Biomedicine (HTB) unit of the FIMM Technology Centre performs high throughput bioassays, mainly cell-based drug screening and RNAi experiments. The unit supports research at University of Helsinki and functions as a national and international infrastructure platform mainly for academic researchers. We currently have an opening for a Post-doc/Research Coordinator for project management and coordination. The primary activities of the position include, but are not limited to:

– Project management and coordination 

– Method and protocol development (especially in 3D tumor models) 

– High throughput screening 

– Administration of the HTB unit
The research coordinator will work independently as well as closely with HTB researchers and staff. The specific tasks include management of academic/company collaborations, in vitro disease modeling, microscopy, administration of unit finances and academic writing of applications and reports, high throughput screening, protocol development and data management.
 
Qualification and experience:
Candidates should have PhD degree in biotechnology, biology, biochemistry, engineering, or a related discipline including proven experience with at least: project management and coordination, supervision of personnel, drug sensitivity testing, handling of clinical samples, cell culture, biochemical, molecular, or cellular techniques, assay development, high content microscopy, flow cytometry, laboratory automation, robotics, and high-throughput screening. The successful candidate is expected to have excellent problem solving, organisational, and analytical skills, and is able to work systematically. In addition, the candidate should be fluent in English, have good interpersonal and communication skills, a service-minded attitude, and be able to work independently as well as within a team.
 
Application and more information at www.fimm.fi/en/open-position/research-coordinator-high-throughput-screening-operations

Tutkimusteknikko, Bio- ja ympäristötieteellisen tiedekunnan biotieteiden laitos, Helsingin yliopisto

9.8.2017 | Ajankohtaista

https://www.helsinki.fi/fi/avoimet-tyopaikat/tutkimusteknikko-biotieteiden-laitokselle

Helsingin yliopiston Bio- ja ympäristötieteellisen tiedekunnan (www.helsinki.fi/bio) biotieteiden laitos hakee

TUTKIMUSTEKNIKKOA

määräaikaiseen työsuhteeseen 21.8.2017-31.7.2019.

Tutkimusteknikko toimii Viikin kampuksella yleisen mikrobiologian osastolla opetuksen ja tutkimuksen elatusaineiden ja liuosten vastuuhenkilönä sekä maljanvalulaitteen ja opetuslaitteiden vastuuhenkilönä. Tutkimusteknikko kuuluu tiimiin, joka tarjoaa teknistä tukea biotieteiden laitoksen yleisen mikrobiologian opetukselle ja tutkimukselle.

Tutkimusteknikon tehtäviin kuuluu elatusaineiden ja liuosten valmistamista, aseptista työskentelyä, mikrobiologista ja molekyylibiologista työskentelyä, mikrobiologisen ja molekyylibiologisen laboratorion peruslaitteiden ja -välineiden käyttöä. Tutkimusteknikko huolehtii kurssisalien siisteydestä ja varustelusta yhteistyössä muiden osastolla toimivien henkilöiden kanssa ja osallistuu yleisiin osastotason tehtäviin. Hän sijaistaa tarvittaessa yleisen mikrobiologian välinehuollossa ja autoklaavien käytössä. Tutkimusteknikon tehtäviin sisältyy ajoittain osaston tutkimusryhmissä avustamista.

Tutkimusteknikko toimii vaihtelevissa tehtävissä yksilöllisesti, tiimissä sekä tutkimusryhmissä. Tehtävät vaativat hyvää organisointikykyä ja paineensietokykyä. Valittavalla henkilöllä tulee olla kyky toimia tarkkuutta vaativissa mikrobiologisissa ja molekyylibiologisissa tehtävissä.

Tehtävässä vaaditaan kykyä itsenäiseen työskentelyyn, mutta myös osallistumista tiimityöskentelyyn sekä vuorovaikutusta suomalaisten ja kansainvälisten opiskelijoiden sekä tutkijoiden kanssa suomeksi ja englanniksi.

Tehtävän menestykselliseen hoitamiseen vaaditaan riittävän hyvää englannin ja suomen kielen taitoa, tietoteknisiä perusvalmiuksia, kiinnostusta uusien menetelmien oppimiseen sekä halua kehittyä työssään ja kokemusta laboratorion laatujärjestelmistä.

Tehtävän palkkaus perustuu yliopistojen palkkausjärjestelmän muun kuin opetus- ja tutkimushenkilöstön vaativuuskehikon tasoon 6. Lisäksi maksetaan henkilökohtaiseen suoriutumiseen perustuva palkanosa. Palkka työsuhteen alkaessa on noin 2100-2400 euroa valittavan henkilön osaamisen ja kokemuksen mukaan. Tehtäviin palkataan neljän kuukauden koeajalla.

Hakemus jätetään yliopiston sähköisen rekrytointijärjestelmän kautta Hae paikkaa –linkistä. Yliopistoon työsuhteessa olevat sisäiset hakijat jättävät hakemuksensa tehtävään SAP HR –portaalissa. Liitä hakemukseen mukaan yhtenä pdf-tiedostona (mieluiten englanniksi):
– ansioluettelo (sisältäen kahden suosittelijan sähköpostiosoitteet ja puhelinnumerot, joista suosittelijat tavoitetaan päiväsaikaan)
– motivaatiokirje (max 1 sivu).

Hakuaika päättyy 16.8.2017 ja haastattelut järjestetään 18.8.2017.

Lisätietoja tehtävästä antavat professori Sarah Butcher ja Viikin laboratoriohenkilöstön poolin koordinaattori Minttu Ahjos (etunimi.sukunimi(at)helsinki.fi).

Rekrytointijärjestelmän tekninen tuki: rekrytointi(at)helsinki.fi

Hae viimeistään 16.08.2017

HAE PAIK­KAA
https://rekry.helsinki.fi/sap/bc/erecruiting/posting_apply?param=cG9zdF9pbnN0X2d…

HAKU PÄÄT­TYY
keskiviikko, elokuu 16, 2017

APPLY NOW for DKFZ Postdoctoral Fellowships 2017

8.8.2017 | Ajankohtaista
www.dkfz.de/en/postdoc-program/Postdoctoral_fellowship.html?m=1493360665

Although there are other ways of becoming a postdoc at our institute, the DKFZ Postdoctoral Fellowships represent the most prestigious and competitive Postdoc recruitment process at DKFZ. It is intended to recruit highly talented and motivated young scientist, who wish to work at the forefront of cancer research in any of basic or translational cancer research labs at the DKFZ.

This program offers up to 10 fellowships per year and provides interdisciplinary training and research opportunities in state-of-the-art research facilities for excellent young scientists, no longer than 2 years past graduation, with a background in biology as well as in physics, mathematics, bioinformatics and other fields.

Deadline for applications is September 15, 2017.

Call for the applicants for PhD student position in project entitled “Herpes virus-nucleus interactions”

8.8.2017 | Ajankohtaista

Position open in the doctoral student program of Department of Biological and Environmental Science, In University of Jyväskylä

The full description of the project can be found in:
https://www.jyu.fi/bioenv/en/study/doctoral-programme/phd-posts/2018/call#Project4

This PhD project aims to unravel the structural changes of chromatin and viral egress dynamics during the lytic infection with HSV-1. In continuation of our prior studies on HSV-1 reorganization of chromatin architecture, we will further analyze the mechanisms of viral impact on chromatin structure and detailed dynamics of viral nuclear exit. These studies are done in close collaboration with Prof. Carolyn Larabell (National Center for X-ray Tomography, Lawrence Berkeley National Laboratory, CA, USA; 1, 3) and other collaboration partners with expertise in advanced imaging, modeling, biophysics, virology and viral therapy.

We are looking for a highly motivated PhD candidate with a Master’s degree and background in one or several of these areas or a related field: cell biology / microbiology / virology / advanced imaging including live cell imaging, confocal microscopy, EM etc. / biophysics, to conduct the experimental work.

· Contact person: Group leader, Adjunct Professor Maija Vihinen-Ranta, maija.vihinen-ranta@jyu.fi

 

Professorship for Clinical Nursing at the University of Cologne

8.8.2017 | Ajankohtaista

The University of Cologne, Faculty of Medicine, posts the position of Professorship (W2) for Clinical Nursing as per the requirements outlined in § 36 of the Universities act of North Rhine-Westphalia (HG NRW). The position is to be filled by Oct. 1st, 2017. The initial appointment will be for 5 years with an option for tenure.

The professorship will be affiliated with the Institute of Health Economics and Clinical Epidemiology. The main objective of this new position is to establish an international competitive
teaching and research program of nursing science with a primary focus on clinical nursing within a high-performance health care system.

Close cooperation, in particular with the Institute of Health Economics and Clinical Epidemiology, the Institute of Medical Sociology, Health Services Research, and Rehabilitation Science (IMVR),
the University Hospital’s Nursing School as well as with actors of the main research areas of the Medical Faculty is explicitly desired.

We are looking for a scientifically established person in the development of clinical nursing. Candidates should have an excellent scholarly record in developing and evaluating nursing
interventions as well as transferring new research findings into nursing practice. She / He possesses profound knowledge of epistemology and research methods, as for example
epidemiological, experimental and mixed-methods as well as qualitative and quantitative methods of health services research.

The successful applicant will be responsible for the design, implementation and preparation of the evaluation of the new dual Bachelor program in clinical nursing. It is the objective of research
and teaching to expand nursing competencies to respond to changing patients’ needs and to establish new interdisciplinary care approaches with better patient outcomes. Therefore,
profound teaching experiences as well as commitment to qualify and encourage nursing students are mandatory. Close cooperation with the University Hospital of Cologne is essential for success of the Bachelor program.

The Faculty of Medicine seeks to appoint a candidate with an excellent track record in research and teaching. Publications in international journals, social skills, the capacity to work in
multidisciplinary teams and to apply for third-party research funds are prerequisites.

The University of Cologne is committed to increase the percentage of women in research and teaching. Applications of women are specifically encouraged. In the case of equal qualifications,
competence, and specific achievements, women will be considered on preferential terms within the framework of the legal possibilities.

The University of Cologne is an equal opportunity employer in compliance with the German disabilities laws. Candidates with disabilities are therefore strongly encouraged to apply.

Further requirements for application include an academic qualification in nursing science as well as postdoctoral lecture qualification (Habilitation/PhD or equivalent) and background in managing
research projects as well as academic teaching experience. We expect a solid professional experience in nursing practice, preferably in an academic setting. Applicants should have very
good command of the German language.

Applications including a letter of motivation, a curriculum vitae, including publication list and a list of third-party grants, reprints of the five most important publications, teaching record, teaching
concept, concepts of research and clinical activities and credentials und records may be sent to the Dean of the Faculty of Medicine, University of Cologne, and submitted via our Academic
Job Portal (https://berufungen.uni-koeln.de ) no later than 31.8.2017.

Open doctoral student positions at the Department of Biological and Environmental Science, University of Jyväskylä

6.7.2017 | Ajankohtaista

The Department of Biological and Environmental Science (University of Jyväskylä, Finland) seeks to recruit 4 doctoral students into the Doctoral Programme in Biological and Environmental Science, starting earliest 1.1.2018. The student should complete the doctoral degree in 4 years. Applications, together with all relevant enclosures, should be submitted using electronic application form at latest 31.8.2017 (in Finnish, in English). After the deadline, each supervisor will select one best candidate for their own project. These top candidates will be asked to write a 2-page long research plan on the thesis topic and will be interviewed. Applications sent by email will not be considered. Only one application per candidate is accepted.

For further information on the project, please contact the supervisor (see below).

Further information on the positions and application form: in Finnish, in English.

Descriptions of the projects (Cell and molecular biology):

2. Evolutionary obstacles and opportunities that govern the dynamics of mobile genetic elements in microbial communities

Resistance to antibiotics along with increased virulence has turned bacterium Klebsiella pneumoniae into one of the most notorious hospital pathogens. Genetically it is a complex puzzle: K. pneumoniae strains carry large conjugative and smaller non-conjugative plasmids; the number of integrated viruses and integrative and conjugative elements (ICEs) vary between bacteria, and some isolates have multiple CRISPR-loci defending the host against external genetic invaders whereas others have none. While the bacterial chromosome provides much of the genetic background for the mobile elements to operate in, it is usually the mobile elements that determine the resistance and virulence of individual strains. This interaction between chromosomal background (that drift away from each other due to neutral mutations) and mobile elements (that often change from one background to another) is understood only to some extent. Elements that are not adapted to the host induce fitness costs and thus are selected against. On the other hand, acquiring a novel element at the right moment can rescue the strain from otherwise lethal situation (for example during antibiotic therapy) or provide unique openings for reproduction (for example by providing genes that allow exploitation of host resources). Mobile elements can also force their uptake even in conditions where it is not favorable to the host.

In the proposed PhD project, the interaction of conjugative elements acquired from epidemic K. pneumoniae against novel genetic backgrounds (other hosts) are mapped in an attempt to understand evolutionary obstacles and opportunities that govern the dynamics of mobile genetic elements in microbial communities. This research provides insights to the emergence of novel hospital pathogens as well as helps determine fundamental eco-evolutionary rules behind inter-host genetic exchange. Methodologically, the project involves microbiology with bacteria, molecular biology, genetics and some bioinformatics. Also, if the applicant is interested, there are opportunities for developing computational models. The applicant would join a dynamic research group that studies antibiotic resistant bacteria originating from hospitals across the world. The project is done in collaboration with researchers from Karolinska Institute (Sweden), National Center for Biotechonology Information (NCBI, USA) and University of Cambridge (UK).

A successful applicant would have a background in cellular and molecular biology, evolutionary genetics, or a related field.

Further information: Academy Research Fellow Matti Jalasvuori, Email: matti.jalasvuori@jyu.fi.; mattijalasvuoriresearch.blogspot.fi.

References
Jalasvuori M. & Koonin E. (2015) Classification of prokaryotic genetic replicators: Between selfishness and altruism. Annals of the New York Academy of Sciences 1341: 96–105.
Ojala V., Mattila S., Hoikkala V., Bamford J.K.H., Hiltunen T. & Jalasvuori M. (2016) Scoping the effectiveness and evolutionary obstacles in utilizing plasmid-dependent phages to fight antibiotic resistance. Future microbiology. 11: 999–1009.

3.Structural and functional characterization of M23 family metalloendopeptidases that lyse bacterial cell wall peptidoglycans

Staphylococcus aureus is a major human and veterinary pathogen. The evident increase in S. aureus resistance to antibiotics demands for the development of new, efficient and cost-effective chemotherapeutics. The use of autolysins (bacterial peptidoglycan hydrolases) for the prevention and treatment of S. aureus infections has been under vivid research and shown very promising results. Autolysins play an important role in the maintenance of the bacterial cell wall. The S. aureus cell wall is composed of two polymers, peptidoglycan and teichoic acid. The former provides the structural framework of the bacterium and protects against turgor pressure, whereas the latter controls the overall surface charge affecting e.g. the activity of peptidoglycan hydrolases and surface adherence ability of the bacterium. To date, two autolysins have been tested as potential staphylolytic agents, S. simulans lysostaphin and Pseudomonas aeruginosa LasA. These cleave pentaglycine bridges present in peptidoglycan. Lysostaphin and LasA belong to the M23 family of zinc-dependent peptidases. Other M23 family members that have been structurally and/or functionally characterized are ALE-1 from S. capitis, LytM and LytU from S. aureus, and NMB0315 from Neisseria meningitidis. The overall structures of the enzymes are strikingly similar, the catalytic efficiencies are, nevertheless, markedly different.

The aim of the project is to unravel underlying structural basis for different substrate specificities, catalytic efficiencies as well as the catalytic mechanism of these very similar enzymes by using various biophysical and biochemical approaches. These studies pave the way for development of new therapeutic agents to treat S. aureus infections. The PhD student will engage in structural and functional characterization of this enzyme family by collecting and analyzing data on protein structure and dynamics along with substrate interactions and kinetics. The Permi Lab is the main user of a recently installed, state-of-the-art Bruker Avance III HD NMR spectrometer operating at 800 MHz of 1H frequency, and has access also to a recently upgraded Bruker Avance III 500 MHz NMR spectrometer. The group has also modern facilities for protein production and purification.

We are looking for a motivated PhD applicant having a Master’s degree in Biology/Chemistry or a related field, and some experience at least in one of the following topics: Structural biology/structural bioinformatics, protein biochemistry, biophysical characterization of proteins, NMR spectroscopy, X-ray crystallography. Additional experience on MD simulations, programming, statistics or bioinformatics is beneficial but not essential.

Further information: Professor Perttu Permi, Email: Perttu.Permi@jyu.fi, Tel. +358 (0)40 8054288

References:
Szweda et al. (2012) Peptidoglycan hydrolases-potential weapons against Staphylococcus aureus. Appl Microbiol Biotechnol. 96: 1157–74.

 

4. Virus-nucleus interactions

Understanding of virus-nucleus interactions is essential for discovering improvements and novel strategies in development of herpes simplex virus type 1 (HSV-1) anti-virals and HSV-1 mediated gene therapy. Moreover, viral infections manipulate the nucleus, and serve as excellent model systems for the characterization of nuclear processes. Our studies advance the current research of virus-nucleus interactions by an interdisciplinary approach involving cell biology and biophysics, combined with state-of-the-art techniques of microscopy imaging, advanced image analysis, and biophysical modeling.

This PhD project aims to unravel the structural changes of chromatin and viral egress dynamics during the lytic infection with HSV-1. In continuation of our prior studies on HSV-1 reorganization of chromatin architecture (1, 2), we will further analyze the mechanisms of viral impact on chromatin structure and detailed dynamics of viral nuclear exit. These studies are done in close collaboration with Prof. Carolyn Larabell (National Center for X-ray Tomography, Lawrence Berkeley National Laboratory, CA, USA; 1, 3) and other collaboration partners with expertise in advanced imaging, modeling, biophysics, virology and viral therapy.

The doctoral student will benefit from supportive research training environment and receive co-supervision by group leader and the senior members of the research team. He/she will use state-of-the-art imaging techniques in University of Jyväskylä, Tampere and Helsinki, attend advanced practical courses on imaging (e.g. EMBO) and national and international scientific meetings, and do site visits in international labs.

We are looking for a highly motivated PhD candidate with a Master’s degree and background in one or several of these areas or a related field: cell biology / microbiology / virology / advanced imaging including live cell imaging, confocal microscopy, EM etc. / biophysics, to conduct the experimental work.

Further information: Group leader, senior lecturer Maija Vihinen-Ranta, Email: maija.vihinen-ranta@jyu.fi

Our most recent publications
Aho V., Myllys M., Ruokolainen V., Hakanen S., Mäntylä E.,Virtanen J.,Hukkanen V., Kühn T., Timonen J.,Mattila K.,Larabell C.& Vihinen-Ranta M (2017). Chromatin organization regulates viral egress dynamics Sci Rep 16(7): 3692.
Pyöriä L., Toppinen M., Mäntylä E., Hedman L., Aaltonen L.-M., Vihinen-Ranta M., Söderlund-Venermo M., Hedman K. & Perdomo M.F. (2017). Extinct type of human parvovirus B19 persists in tonsillar B cells. Nat Commun 4(8): 14930.
Myllys M., Ruokolainen V.,Aho V., Smith E., Hakanen S., Peri P.,Salvetti A., Timonen J., Hukkanen V.,Larabell C.& Vihinen-Ranta M. (2016).Herpes simplex virus 1 induces egress channels through marginalized host chromatin. Sci Rep, 28(6): 28844.
Aho V., Mattila K., Kühn T., Kekäläinen P., Pulkkinen O., Brondani Minussi R., Vihinen-Ranta M. & Timonen J. (2016). Diffusion through thin membranes: Modeling across scales. Phys Rev E 93: 043309.

Post-doc position in mathematical modeling on phenotypic evolution and embryonic development at the University of Helsinki

5.7.2017 | Ajankohtaista
1.Job/ project description:
 
The postdoc could choose between three main research projects:
 
a. Mathematical modeling of phenotypic evolution in populations with embryonic development.
 
b. Mathematical modeling of gene network and embryonic development evolution.
 
c. Mathematical modeling of organ development and their evolution in mammalian teeth or Drosophila wing.
 
The actual project will be chosen together with the candidate depending on his/her interests and skills.
 
The research will take place in the Isaac Salazar-Ciudad’s group in the Center of Excellence in Experimental and computational developmental biology of the Biotechnology Institute of the University of Helsinki, Finland.
 
The job is for 1 year and renewable for 1 extra year.
 
2. Background:
 
Why organisms are the way they are?
 
Can we understand the processes by which complex organisms are build in each generation and how these evolved?
 
The process of embryonic development is now widely acknowledged to be crucial to understand evolution since any change in the phenotype in evolution (e.g. morphology) is first a change in the developmental process by which this phenotype is produced. Over the years we have come to learn that there is a set of developmental rules that determine which phenotypic variation can possibly arise in populations due to genetic mutation (the so called genotype-phenotype map). Since natural selection can act only on existing phenotypic variation, these rules of development have an effect on the direction of evolutionary change.
 
Salazar-Ciudad’s group is devoted to understand these developmental rules and how these can help to better understand the direction of evolutionary change. The ultimate goal is to modify evolutionary theory by considering not only natural selection in populations but also developmental biology in populations. For that aim we combine mathematical models of embryonic development that relate genetic variation to morphological variation with population models. The former models are based on what is currently known in developmental biology.
 
Salazar-Ciudad’s group is in close collaboration with Jukka Jernvall’s group and other groups within the center of excellence in experimental and computational developmental biology. The center includes groups working in tooth, wing, hair and mammary glands development. In addition to evolutionary and developmental biologists the center of excellence includes bioinformaticians, populational and quantitative geneticists, systems biologists and paleontologists.
 
“The Academy of Finland’s Centres of Excellence are the flagships of Finnish research. They are close to or at the very cutting edge of science in their fields, carving out new avenues for research, developing creative research environments and training new talented researchers for the Finnish research system.”
 
3. Requirements:
 
The applicant must hold a PhD in either evolutionary biology, developmental biology or, preferably, in evolutionary developmental biology (evo-devo). Applicants with a PhD in theoretical or mathematical biology are also welcome.
 
Programming skills or a willingness to acquire them is required.
 
The most important requirement is a strong interest and motivation on science and evolution. A capacity for creative and critical thinking is also required.
 
4. Description of the position:
 
The fellowship will be for a period of up to 1+1 years (100% research work: no teaching involved).  Salary according to Finnish postdoc salaries.
 
5. The application must include:
 
-Motivation letter including a statement of interests
-CV (summarizing degrees obtained, subjects included in degree and grades, average grade).
-Summary of PhD project, its main conclusions and its underlying motivation.
 
-Application should be sent to Isaac Salazar-Ciudad by email: isaac.salazar@helsinki.fi
 
No official documents are required for the application first stage but these may be required latter on.
 
6. Deadline:
 
There is no specific deadline, the position will be filled as soon as a suitable candidate is found.
 
7. Examples of recent publications by Isaac Salazar-Ciudad group.
 
–          Brun-Usan M, Marín-Riera M, Grande C, Truchado-Garcia M, Salazar-Ciudad I. A set of simple cell processes is sufficient to model spiral cleavage. Development. 2017 Jan 1;144(1):54-62.
–          Salazar-Ciudad I, Marín-Riera M. Adaptive dynamics under development-based genotype-phenotype maps. Nature. 2013 May 16;497(7449):361-4.
–          Salazar-Ciudad I, Jernvall J. A computational model of teeth and the developmental origins of morphological variation. Nature. 2010 Mar 25;464(7288):583-6.
 
 
8. Interested candidates should check our group webpage:
 
www.biocenter.helsinki.fi/salazar/index.html
 
The center of Excellence webpage: www.biocenter.helsinki.fi/bi/evodevo/ECDev.html