16.6.2018 | Ajankohtaista
Solubiologi 1/2018 lehden pääkirjoitus sekä artikkeleiden abstraktit löytyvät nyt nettisivuiltamme! Muistathan, että yhdistyksen jäsenillämme on mahdollisuus lukea uusin Solubiologi-lehti myös jäsenintrassamme pdf-muodossa. Intrasta löytyy lehden lisäksi myös muunmuassa lista yhdyshenkilöistämme, joihin jäsenemme voivat olla yhteydessä esimerkiksi gradu- tai harjoittelupaikan tiimoilta. Tarkista tunnuksesi jäsenintraan viimeisimmästä jäsenkirjeestä!
16.6.2018 | Ajankohtaista
Pääkirjoitus, 28.05.2018
Suomen kesä on alkanut erittäin lämpimästi ja kesän tuloon liittyy tietysti myös vuoden ensimmäinen Solubiologi. Tämän vuotisen kevään numeron aloittaa Marjaana Parikainen, joka avartaa meille kollageeni I:stä sitovan α2β1-integriinin roolia eturauhassyövässä, ja tämän vaikutusta geeniekspressioon ja invaasioon. Seuraavaksi Teemu Syrjälä kertoo meille brominoituneista palonestoaineista ja niiden vaikutuksista syöttösoluihin. Tämänkertaisen tietopaketin päättää Moona Huttusen ulkomaankirjeenvaihtotervehdys, jossa käydään läpi hänen jo kolme vuotta kestäneitä seikkailuitaan Lontoossa University Collegessa, Englannissa.
Tänä kesänä saimme mahdollisuuden lähteä laboratorioryhmän kanssa joukolla Suomea pakoon vierailulle TuE:hen (Technische Universiteit Eindhoven) Eindhoveniin, Hollantiin, jossa tapasimme ryhmänjohtajamme Cecilia Sahlgrenin toisen ryhmän tiimiläisiä. Ahkerana professorina Cecilia pyörittää siis kahta kokonaisuutta, ja olihan se mielenkiintoista päästä tutustumaan teknillisen yliopiston työtapoihin ja tekniikkoihin. Tämä alunperin 1956 perustettu yliopisto kouluttaa pääasiassa insinöörejä teknologian alalla, mutta solu- ja kudostekniikan ja mikrofabrikoinnin laboratoriot yhdistävät solubiologiaa ja biotekniikkaa. Yhteistyö insinöörien ja solubiologien välillä on tärkeässä asemassa TuE:ssa, kun kehitetään esimerkiksi keinotekoisia sydänläppiä tai mikrosiruja, joilla halutaan simuloida erilaisia olosuhteita, joihin solut voivat joutua. Lopullisena päämääränä on kehittää niin sanottuja organ-on-a-chip –menetelmiä, joilla voitaisiin simuloida kokonaisia elimiä pienoismallissa.
Tämä jäänee omalta osaltani päätoimittajuuteni viimeiseksi Solubiologi-lehdeksi, koska syksyllä puikkoihin tarttuu J.J. Hyvää kesän jatkoa kaikille toivottaa SEb ja koko Solubiologin väki.
– Sebastian Landor
”I am the easy-going doctor who does not need to salute properly. You will find that I am always removing my gloves. The reason for my lab coat being a slightly different color to yours is never explained.”
1. Artikkeli. Kollageenireseptori α2-integriini säätelee eturauhassyöpäsolujen geeniekspressiota ja invaasiota, Marjaana Parikainen (FM)
Erikoistyössä tutkittiin α2-integriinin vaikutusta eturauhassyöpäsolujen geeniekspressioon sekä solujen migraatioon ja invaasioon neljällä α2-integriiniä erilaisesti ilmentävällä DU145-solutyypillä. α2-integriinin havaittiin säätelevän tiettyjen geenien ilmentymistä sekä RNA- että proteiinitasolla mutta se ei vaikuttanut säätelemiensä proteiinien lokalisaatioon solussa. Lisäksi havaittiin, että α2β1-kollageeni I -vuorovaikutus lisäsi solutyyppien välisiä RNA-tason ilmentymiseroja suurimmalla osalla tutkituista 12 geenistä, minkä perusteella α2-integriinin aktivoituminen ja signalointi ligandivuorovaikutuksessa säätelee näiden geenien ilmentymistä. α2-integriiniä ilmentävät solut invasoivat enemmän Matrigeeliin ja kollageeni I:een kuin α2-integriiniä ilmentämättömät solut. Tulosten perusteella α2β1-integriiniin kohdentuvaa syöpähoitoa voitaisiin mahdollisesti hyödyntää eturauhassyövän luumetastaasien estämiseen.
2. Artikkeli. The effects of some common brominated flame retardants (bfrs) on cell degranulation and cell viability in a mast cell line, Teemu Syrjälä (Biomedical Laboratory Scientist, Bachelor of Health Care; EQF6)
The aim of this study was to investigate the effects of two commonly used brominated flame retardants, tetrabromobisphenol A (TBBPA) and hexabromocyclododecane (HBCD), on degranulation and viability of a mast cell line RBL-2H3. Assays measuring and monitoring cell viability and the release of inflammatory proteins via degranulation were developed. The results showed that both TBBPA and HBCD cause substantial cell death over a long-term exposure in vitro. Both compounds caused some degranulation of the cells, although the results from HBCD turned out to be quite modest compared to those gotten from TBBPA. TBBPA greatly induced cell death by apoptosis while only a very small degree of necrotic cell death was observed. While the degree of necrosis caused by HBCD remains unknown, it was shown to also induce apoptotic cell death at least to some extent. The study concludes that TBBPA, based on the results, does seem to be a mast cell sensitizing agent. HBCD has great potential to have similar effects, although this requires further research.
3. Artikkeli. Ulkomaankirjeenvaihtaja, London University College (UCL) Englanti, Moona Huttunen (FT)
15.6.2018 | Ajankohtaista
We are recruiting a Ph.D student to join our young and dynamic research team of translational research at the Department of Oral and Maxillofacial diseases, University of Helsinki (https://www.helsinki.fi/en/researchgroups/translational-research-on-oral-and-maxillofacial-sciences/research).
The position is available from 1st September 2018 for one year with the possibility of extension. You will be the part of the multifaceted projects aimed at understanding the role of extracellular vesicles in osteosarcoma development and progression; developing 3D models for osteosarcoma; bone tissue engineering/applications of biomaterials and stem cells. In addition to strong written and oral communication skills, experience with techniques in genetics, cell biology, cell imaging, RNA sequencing, biochemistry and bioengineering are considered favorable.
14.6.2018 | Ajankohtaista
The Institute for Molecular Medicine (FIMM) and Bayer are seeking a joint postdoctoral researcher who has interest in anticancer drug development, and experience in cell and molecular or computational biology, or other related areas. The successful candidate will gain a rich and varied insight into drug development processes through exposure to both biomedical research at FIMM and clinical trials management at Bayer.
The application deadline is 25.6.2018 at 23.59 EET. Applications are submitted by completing the application form and submitting a CV and a cover letter as a single PDF file (max 5 pages) in English through the University of Helsinki electronic recruitment system https://www.helsinki.fi/en/open-positions/fimm-bayer-joint-postdoctoral-researcher. Internal applicants (i.e., current employees of the University of Helsinki) must submit their applications through the SAP HR portal.
13.6.2018 | Ajankohtaista
The discovery of a fatal neurodegenerative disease in childhood with fibrosis, and cerebral angiomatosis (FINCA disease) has highlighted the importance of NHLRC2 in the central nervous system (Uusimaa et al. 2018) (doi: 10.1007/s00401-018-1817-z). We are now looking for a postdoctoral scientist to focus on characterizing the role of NHLRC2 during neurogenesis in a two-year project funded by the Academy of Finland.
Applications, together with all relevant attachments, must be submitted using the electronic application form by 31.7.2018.
13.6.2018 | Ajankohtaista
We are now recruiting a top caliber Medical Scientific Liaison / Scientific Advisor to join the Bayer Finland Medical Affairs team. As a Medical Scientific Liaison you will serve as the primary scientific resource for the medical community by responding to their information needs on Bayer products and therapies. You will facilitate internal and external scientific collaborations with Physicians and other Health Care Professionals and support them with accurate and updated medical information, as well as identify, initiate and implement medical based projects. You will organize and support scientific events including peer to peer communication, scientific exchange meetings and advisory boards. You will act as a strategic partner for the cardiology brand team to share feedback from the market internally, while being fully updated and maintain the highest level of clinical and scientific knowledge within the therapy areas.
YOUR TASKS AND RESPONSIBILITIES
- act as a scientific expert between Bayer and the medical community through the dissemination and education of scientific data and material
- plan, prepare and engage with Health Care Professionals as an information scientist both proactively and reactively via various engagement tactics and formats
- provide dissemination, clarification and education of scientific data and professional literature
- establish long-term scientific/strategic relationships with key individuals, major medical associations and academic centers of excellence
- interact with key external medical and pharmacy professionals via one-on-one interaction, small group discussion, symposia lecture presentations and interactions associated with medical education programs
- answer medical / scientific queries of internal and external stakeholders
- attend congresses and conventions, interact with Health Care Professionals, establish new contacts and gather competitive intelligence
- plan and organize scientific training and education events with Health Care Professionals within their specific therapeutic area or product
- submit timely reports and track activities against agreed objectives
- The role is field-based, which means 70-75% travelling time
THE IDEAL CANDIDATE
We expect you to have a medical or scientific background with established relations to the medical community, and preferably a Ph.D. or other strong background in the relevant therapeutic area. You have experience from the industry in a relevant role and knowledge of the clinical development process. You are capable of comprehending large amounts of scientific content which you can communicate in a clear and concise way and have excellent presentation skills. As a person you are a team player, self-driven, independent, resourceful and trustworthy. You have strong statistical skills with ability to extract insights from data. We expect you to enjoy creating new contacts and have good social skills. You are also excellent at communicating, both verbally and in writing. You are fluent in Finnish as well as English orally and written.
Please submit your application with your CV and salary request by June 24 at the latest. Candidates will be reviewed on a continuous basis.
11.6.2018 | Ajankohtaista
Solubiologi 1/2018 on lähtenyt painoon, joten saat uusimman lehden pian kotiisi!
Muistathan, että Solubiologi-lehdellä on menossa kampanja, jossa jokaisesta julkaistusta artikkelista myönnetään 100 euron kirjoituspalkkio! Solubiologi-lehdessä julkaistaan myös opiskelijoiden kirjoittamia artikkeleita, joten opiskelijoilla on oiva mahdollisuus julkaista esimerkiksi kandi tai pro gradu -työnsä yhdessä ohjaajan kanssa. Lisäksi lehti on hyvä kanava muun muassa tutkimusryhmien esittelyille. Katso kirjoitusohjeet nettisivuiltamme ja ota yhteyttä paikallistoimittajaan tai päätoimittajaan!
8.6.2018 | Ajankohtaista
Suomen Solubiologit ry:n hallitus kokoontui perjantaina 8.6. ravintola Zetorissa, Helsingissä. Kokouksessa suunniteltiin syksyn seminaaria, jonka teemoiksi on kaavailtu rohkeutta ja innovatiivisuutta. Yksi täydellisesti teemoihin sopiva puhuja on jo varmistunut, ja tänään saatiin mietittyä muitakin rohkeita solu- ja molekyylibiologian alan toimijoita. Lisäksi suunniteltiin tapahtumaa ensi vuodelle, joka on Suomen Solubiologit ry:n 45v-juhlavuosi! Stay tuned!
P.S. Suomen Solubiologit ry löytyy nyt myös Instagramista tunnuksella suomensolubiologit, tule mukaan seuraamaan toimintaamme myös sinne!
7.6.2018 | Ajankohtaista
Indiana University School of Medicine, Department of Anesthesia, has a federally-funded postdoctoral position open in a cutting-edge Shock, Trauma and Neuroscience Research Laboratory that focuses on immunologic response to traumatic brain injury (TBI), trauma, and hemorrhagic shock.
The candidate will lead studies in the following areas:
1) persistent pain due to mild traumatic brain injury in adults: alterations of brain function, central sensitization, and inflammatory processes;
2) monocyte/macrophage transcriptional response to TBI in rodent models of mild TBI and polytrauma;
3) mechanisms of immune modulating therapy on the anatomic, physiologic, and transcriptional response to TBI, polytrauma, and hemorrhagic shock;
4) characterization of a model of mild TBI (concussion) for the long-term study of microglial and macrophage gene expression and response to immune modulating therapy; and
5) precision typing to determine sensitivity and tolerance of TBI and hemorrhagic shock.
Competitive salary and benefit package.
Specific Responsibilities
· Process and analyze clinical blood samples derived from mild TBI patients, and assist in quantitative sensory testing of patient volunteers.
· Induce experimental traumatic brain injury alone or combined with polytrauma in rodents; harvest and process brain, muscle, bone, and viscera; perform and analyze advanced flow cytometry/cell sorting; administer, and collect and analyze RNA sequencing data.
· Supervise students and other techs working in the lab.
· Help write and contribute to publications resulting from research done in the lab.
· Perform other duties as assigned.
Candidates must be highly self-motivated and self-sufficient with PhD or MD. A strong background in immunology and flow cytometry is a requirement and some background in neuroscience and pain would be preferred. Experience with rodent models is ideal. Experience with RNA sequencing is desired.
Indianapolis is a great place to visit. Home to one of the world’s largest children’s museums, as well as professional and college sports teams and miles of recreational trails, the Circle City has plenty to keep locals entertained. Indianapolis’ lively downtown is easily walkable. With so many things to do, Indianapolis allows its residents to experience big-city living without too much effort,https://realestate.usnews.com/places/indiana/indianapolis
Contact Fletcher White at fawhite@iu.edu for more information or to apply.
Indiana University School of Medicine is an Equal Opportunity, Affirmative Action Employer of all protected classes, including veterans and individuals with disabilities. Women, racial and ethnic minorities, individuals with disabilities, and veterans are encouraged to apply. Hiring is contingent upon eligibility to work in the United States.
4.6.2018 | Ajankohtaista
ASSISTANT PROFESSOR / ASSOCIATE PROFESSOR / PROFESSOR IN NEUROBIOLOGY
The successful applicant may be appointed to a permanent full professorship or a fixed-term associate / assistant professorship (tenure track) depending on their qualifications and career stage.
The professorship is based in the Molecular and Integrative Biosciences Research Programme, which is one of the three Research Programmes in the Faculty. Neurobiology, including electrophysiology and molecular and developmental biology of the brain, is an area of strength of the Programme. The other areas of strength of the Programme are cell and developmental biology, genetics, virology and structural biology (for further information see https://www.helsinki.fi/en/faculty-of-biological-and-environmental-scien…).
The research and teaching activities at the Viikki Campus are supported by state-of-the-art infrastructures including core facilities for e.g. DNA sequencing and genomics, proteomics, metabolomics, lipidomics, and light- and electron microscopy including two-photon confocal and cryo-electron microscopes. Within the Research Programme, neurobiology research is supported by an in-house animal facility, and electrophysiological instrumentation is abundant in the laboratories. There are numerous research groups in the Viikki Campus that focus on e.g. molecular and developmental neurobiology, mechanisms of cell and network level activity, as well as on neurodevelopmental and neurodegenerative diseases. The Viikki Campus is one of the three centres of neuroscience research in the Helsinki area, the other two being located in the Meilahti Campus, and at the Aalto University.
The professor is expected to contribute to the advancement of neurobiology in the Molecular and Integrative Biosciences Research Programme. Demonstrated excellence and scientific leadership in the field of neurobiology is a requirement.
The main tasks of the assistant professor / associate professor / professor in neurobiology will include scientific research and research-based teaching, and participation in international collaboration. In addition to giving lectures and courses, the professor will supervise undergraduate and postgraduate students and participate in the development of Bachelor’s, Master’s and doctoral programmes, in particular the Faculty’s Master’s Programme in Neuroscience (https://www.helsinki.fi/en/programmes/master/neuroscience) and the Doctoral Programme Brain and Mind (https://www.helsinki.fi/en/research/doctoral-education/doctoral-schools-…) which is hosted by the Faculty.
An appointee to a full professorship shall hold a doctoral degree and have top-level scholarly qualifications and experience in the supervision of scientific research, along with the ability to provide top-level research-based teaching as well as to supervise theses and dissertations. In addition, the appointee shall present documentation of international cooperation in the field of research that he or she represents.
An appointee to an assistant / associate professorship in the tenure track system (https://www.helsinki.fi/en/university/working-at-the-university/tenure-t…) shall hold a doctoral degree, have the ability to conduct independent scholarly work and have the teaching skills necessary for the position. In addition, applicants for assistant / associate professorships shall demonstrate their capability and motivation for an academic career through publications and other means.
When considering the applicant’s qualifications, attention will be given to scientific publications, teaching experience and pedagogical training as well as the applicant’s participation in doctoral education. Furthermore, account shall also be taken of the applicant’s activity in the scientific community, success in obtaining external research funding, international research experience and positions in Finnish and international organizations.
There is no requirement to be proficient in Finnish for foreign citizens, non-native Finnish citizens or citizens who have not been educated in Finnish or Swedish. To successfully attend to the duties of the position, the appointee must have good skills in English.
The professor’s salary will be based on levels 8−10 and the assistant / associate professor’s on level 7 of the job requirement scheme for teaching and research personnel in the salary system of Finnish universities. In addition, the appointee will be paid a salary component based on personal work performance. The gross monthly salary will be approximately 4500–8000 €, depending on the appointee’s career stage and scholarly qualifications.
Applicants are requested to enclose with their applications the following documents in English:
1) CV
2) A report (max. 3 pages) on the applicant’s previous research activities, and a plan for how the applicant intends to develop their research and focus their activities in the future
3) A report (max. 3 pages) of experience and merits which are of relevance for the evaluation of teaching skills (please see the evaluation guidelines at https://www.helsinki.fi/sites/default/files/atoms/files/bytdk_teaching_s…)
4) A numbered list of publications in English and other works with which the applicant wishes to demonstrate their competence and merits, with five most important publications highlighted with brief explanations.
The Faculty may request applicants to submit 5-10 publications of their choice to be sent to the assessors.
Applications must be submitted through the University’s electronic recruitment system by clicking on the link below. Internal applicants (i.e., current employees of the University of Helsinki) must submit their applications through the SAP HR portal. The deadline for applications is 30 September, 2018.
Further information can be obtained from the Director of the Molecular and Integrative Biosciences Research Programme, Professor Juha Partanen, juha.m.partanen (at) helsinki.fi, tel. +358 (0) 2941 59382 or from Professor Juha Voipio, juha.voipio (at) helsinki.fi, tel. +358 (0) 2941 59858.
Due date
30.09.2018 23:59 EEST
