14.2.2017 | Ajankohtaista
We are looking for a doctoral student to join the Celiac Disease Research Center (CeliRes). CeliRes is committed to conducting high-quality multidisclipinary research ranging from epidemiological and clinical studies to genetics, immunobiology and microbiology. The project of the doctoral student will involve the pathogenetic mechanism of celiac disease and its skin manifestation, dermatitis herpetiformis. A successful candidate has MSc degree/equivalent and is self-motivated. Previous experience in biomedical and immunobiological research techniques is considered as an advantage.
Salary: The salary will be based on the demand level chart for the teaching and research staff of Finnish Universities. The preliminary level of demand is 2-4. In addition to the basic salary, a supplementary salary component will be paid according to the personal performance.
There is a four month’s trial period in the beginning of the employment.
Application process: Applications must be submitted by the online application form of the University of Tampere at https://uta.rekrytointi.com/paikat/?o=A_RJ&jgid=1&jid=889 by March 13th, 2017, at 15.45 local time. Please attach to your application a letter of motivation (indicating who you applied for this position), and a CV including two references with their contact information.
For additional information, please contact:
University Researcher Katri Lindfors katri.lindfors (at) uta.fi (position)
HR Specialist Jonna Rinne jonna.rinne (at) uta.fi (recruitment process).
13.2.2017 | Ajankohtaista
CAPICE: general description
In this ambitious and inspiring network, 12 Early Stage Researches (ESRs; PhD-level training) will be trained in the broad field of psychiatric genomics, investigating the role of genetics and epigenetics, and their interplay with the environment, in the development and persistence of childhood and adolescent psychopathology. Through biological pathway analyses, drug target validation and the building of prediction models, these results will ultimately be translated to the clinic. Analyses will be performed in large international collaborations, making use of the wealth of data available across a range of European birth and adolescent cohorts.
ESRs will be supervised by leaders in the field located at institutions across Europe in Italy (University of Cagliari), The Netherlands (Vrije Universiteit Amsterdam, Erasmus University Medical Center Rotterdam, University of Twente), Sweden (Karolinska Institute, Gøthenburg University, Janssen Pharmaceutical) and the UK (Imperial College London, King’s College London, University of Bristol). At the end of this project the ESRs will be part of a broad international network consisting of academic and non-academic partners.
Candidates with a background in statistical genetics, bioinformatics, psychology, psychiatry or neuroscience are invited to apply.
More information at http://academicpositions.eu/ad/capice/2017/12-early-stage-researcher-positions-for-phd-studies-for-msca-itn-project-capice/97232
Application deadline: 1.3.2017
13.2.2017 | Ajankohtaista
https://www.researchgate.net/job/883483_PostDoc_Position-Single-cell_and_personalized_regulatory_genomics
JOB DESCRIPTION
Post-doc position in single-cell and personalized regulatory genomics
Biozentrum, of Basel, Switzerland
A post-doctoral position is available in the group of Prof. Erik van Nimwegen at the Biozentrum of the of Basel and Swiss Institute of Bioinformatics.
We are looking for highly motivated individuals with strong mathematical and computational skills that are interested in performing theoretical/computational research in regulatory genomics, especially in the areas of single-cell gene regulation and personalized regulatory networks.
Our research group is highly interdisciplinary, involving both an experimental section where researchers with a background in molecular biology are experimentally studying genome evolution and gene regulation at the single cell level in bacteria, and a theoretical section where researchers with backgrounds in theoretical physics, computer science, and applied mathematics are using techniques from Bayesian probability, evolutionary theory, dynamical systems theory, and stochastic processes, to study the function and evolution of genome-wide regulatory networks in cells. We are particularly interested in uncovering the principles by which genome-wide regulatory networks specify and maintain cell identity in multi-cellular organisms, how cells control and exploit the noise in gene regulatory processes, and how gene regulation evolves. A list of our group’s publications can be found here.
For this position we are looking for candidates interested in developing methods for analysis of the regulatory networks that control cell fate decisions and cell identity in multi-cellular eukaryotes.
Our lab has long worked on developing methods for genome-wide prediction of regulatory sites,e.g Siddhartan et al. 2005, Pachkov et al. 2007, Arnold et al. 2011, Khorshid et al. 2013, and in recent years we have developed several methods for analyzing gene regulatory networks by modeling genome-wide gene expression and chromatin state data in terms of constellations of regulatory sites, e.g. Fantom Consortium 2009, Arnold et al 2012, Balwierz et al. 2014. We are interested in extending these methods to model single-cell regulatory dynamics and cell fate decisions by analysis of single-cell RNA-seq data, and to incorporate the effects of SNPs and other genetic variants on the functioning of gene regulatory networks in mammals. As part of these efforts we are collaborating within the BrainStemX project on mammalian forebrain development. The precise topic of the research project will be determined jointly with the candidate and candidates that display initiative and independence will be given priority.
DESIRED SKILLS AND EXPERIENCE
- Candidates should have strong mathematical and computational skills, and experience with analysis of next-generation sequencing data
- Experience in areas such as stochastic processes, dynamical systems theory, and Bayesian statistics is a plus
- Candidates do not necessarily have to have a biological background but should have a strong desire to directly work with experimental biologists
- The candidates should have a good knowledge of English
- German is helpful but not necessary
- The salary is generous and is set according to the guidelines of the Swiss National Science Foundation
- The start date will by mutual arrangement
To apply, please send a single pdf containing your application letter, CV, and the names of two references by clicking on the ”Apply for this job” button.
Review of applications will begin immediately.
ABOUT THE EMPLOYER
Basel is a very international city and a center of life science research, with over 900 life science research companies in the area, including Novartis and Roche. Several other academic institutions are also in the city, including the Friedrich Miescher Institute, the ETH Zurich Biosystems Science and Engineering Department, and the Swiss Tropical Institute. The city is less than 5km from both France and Germany and an hour and a half from the Swiss Alps.
8.2.2017 | Ajankohtaista
Faculty of Medicine and Life Sciences at the University of Tampere invites applications for a Postdoctoral Researcher position. The fixed-term position will be filled for one year (twelve months) with a possibility for extension for at least two additional years, starting on March 1, 2017, or as soon as possible.
8.2.2017 | Ajankohtaista
Job Description
The European Molecular Biology Laboratory (EMBL) invites you to apply for PhD positions in Heidelberg, Grenoble Hamburg, Hinxton (near Cambridge), and Monterotondo (near Rome).
Would you like to contribute your creativity to an international team of scientists from all disciplines focusing on basic research in the area of molecular life sciences?
We invite candidates with background in Biology, Chemistry, Physics, Mathematics, Computer Science, Engineering and Molecular Medicine to apply.
EMBL opens the door to your scientific career: our students have an outstanding publication record, are a vital part of our global collaborations and receive their degrees jointly with our network of excellent partner universities in 17 different countries.
Our PhD positions come with generous fellowships, including broad health care benefits and pension access.
Application Instructions
The registration deadline is 19.10.2015
The deadline for submission of the online application is 26.10.2015
Interviews will take place in February 2016
Additional Information
EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation.
Successful candidates would start their work at EMBL latest by mid of October 2016.
30.1.2017 | Ajankohtaista
https://www.helsinki.fi/fi/avoimet-tyopaikat/assistantassociate-professor-or-professor-in-behavioural-genetics-profi2
https://www.helsinki.fi/fi/avoimet-tyopaikat/assistantassociate-professor-or-professor-in-behavioural-brain-research-profi2
30.1.2017 | Ajankohtaista
Postdoc/Research Fellows are being recruited to our laboratory at the National University of Singapore (NUS). We are seeking talented, innovative and enthusiastic researchers with a PhD awarded within the last 5 years. Carlos Ibanez is Professor at the Department of Physiology, Yong Loo Lin School of Medicine, NUS, Singapore, and Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Cell signaling
The successful candidate will have a strong background in studies of cell signaling using molecular, cellular and biochemical methods. The aim of the project is to elucidate mechanisms of differential signaling by death receptors through the NFkB, c-Jun kinase and RhoA GTPase pathways, among others, taking advantage of recent knowledge on structure-function relationships in this class of receptors as well as a large collection of mutants developed at our laboratory. Strong expertise in cell and molecular biology techniques is essential. Additional expertise in live cell imaging will also be an asset to the project.
Drug Discovery
The successful candidate will have a strong background in studies of intracellular signaling involving biochemical assays, gene reporter assays and microscopy techniques. The aim of the project is the identification and characterisation of novel small molecule modulators (inhibitors and activators) of growth factor receptor signaling taking advantage of a novel screening strategy developed in the laboratory based on recent knowledge on the mechanisms of activation and downstream signal propagation of death receptors and receptors of the TGFb superfamily. Strong expertise in cell and molecular biology techniques is essential. Additional expertise in small molecule screening and/or chemistry will also be an asset to the project.
Applications, including CV, list of publications and statement of future interests should be sent to Prof. Carlos Ibanez http://carlosibanezlab.se/NUS/open-positions/ 
Applicants should arrange to have at least two confidential letters of reference sent independently by referees to this email address.
Funding is available for an initial period of 2 to 3 years, starting any time during 2017.
Deadline for the application is January 31, 2017.
30.1.2017 | Ajankohtaista
UCSF Postdoctoral Position: Molecular Neuroscience
The Ron laboratory at UCSF is inviting applications for postdoctoral position to investigate signaling pathways and plasticity mechanisms that underlie addiction.
Research in the Ron lab uses state-of-the-art techniques including, molecular/genetic technique for gene manipulations in subpopulations of neurons in vivo, viral-mediated gene delivery, RNA-seq and analysis in combination with behavioral approaches in rodent to study signaling cascades within circuitries that underie alcohol abuse disorders (Liu et al. Molecular Psychiatry 2016, Ron and Barak Nature Reviews Neuroscience 2016, Warnault et al., Biological Psychiatry 2015, Darcq et al., Molecular Psychiatry 2014, Barak et al. Nature neuroscience 2013). Highly motivated Molecular Neuroscientist candidates that will be graduating within the next year are encouraged to apply. Candidates must have a proven track record state of the art molecular biology techniques. Preference will be given to candidates with a solid background in signal transduction. The position offers an opportunity to be part of a collaborative team at the vibrant research community at the UCSF Mission Bay campus.
Please send Curriculum Vitae and names of three references to: Professor Dorit Ron, Department of Neurology, University of California San Francisco, dorit.ron@ucsf.edu
11.1.2017 | Ajankohtaista
Our lab studies how cancer cells develop drug resistance, and more specifically, how tumor microenvironment provides support and protection for tumor cells. Our aim is to develop better treatment strategies to overcome this tumor microenvironment mediated drug resistance.
To investigate these topics we utilize both normal and cancer cells in 3D organoid culture systems, which mimic the architecture and organization of tissues. We use this platform in co-culture systems to understand how stromal and epithelial cells communicate with each other, and have also adopted the use of organoids for larger scale methodologies, such as proteomics, metabolomics, RNA-seq and ribosome foot-printing experiments to gain insight into multiple mechanisms by which cancer cells become drug resistant in 3D environments.
Our group is located in the Longwood medical area, at the Beth Israel Deaconess Medical Center, with several established collaborations with groups in the Harvard Medical School, MIT, Yale, Weill Cornell and MD Anderson. This environment provides unique opportunities for performing cutting-edge science, training in state-of-the-art technologies, forming new collaborations, and developing new technologies.
We are looking for highly motivated individual(s) who have recently finished their PhD, with excellent communication and critical thinking skills, and who are able to work as part of a team. Training in cell biology, molecular biology and microscopy, and basic understanding of cell signaling networks is required.
Or refer to the relevant publications: Muranen et al. Cancer Cell 2012, Muranen at al. Cancer Research 2016, Muranen et al. Nature Communications 2017 (http://rdcu.be/oqQ6).
Please send a cover letter with short description of your research interests and previous experience, current CV, and names of three references to tmuranen@bidmc.harvard.edu.
11.1.2017 | Ajankohtaista
The University of Tampere is a multidisciplinary international academic institution with 30,000 students and 2,200 faculty and staff, located in the dynamic city of Tampere, Finland. The University aims at fostering an international academic community characterized by high-quality, original research with societal impact.
Faculty of Medicine and Life Sciences at the University of Tampere invites applications for a Doctoral Student position. The fixed-term position will initially be filled for one year (twelve months) starting on March 1, 2017, or as agreed.
Requirements
We are looking for a doctoral student to join Immunoregulation group that investigates how the Proprotein Convertase (PCSK) enzymes regulate the immune system (see for example J Immunol. 2014 Dec 1, Oncotarget. 2016 Aug 5 andOncoImmunology Vol 5, 2016). A successful candidate has MSc degree/equivalent, is self-motivated, curious and interested in the mechanisms of immunity. Previous experience in biomedical research techniques, such as cell culture, FACS and/or in vivo models is advantageous.
Salary
The salary will be based on the demand level chart for the teaching and research staff of Finnish Universities. The preliminary level of demand is 2-4. In addition to the basic salary, a supplementary salary component will be paid according to the personal performance. There is a four month’s trial period in the beginning of the employment.
Application process
Applications must be submitted by the online application form of the University of Tampere https://uta.rekrytointi.com/paikat/?o=A_RJ&jgid=1&jid=866 by 12 February, 2017, at 15.45 local time. Please attach to your application a letter of motivation and CV including two references and their contact information.
For additional information, please contact:
Associate Professor (tenure track) Marko Pesu, marko.pesu (at) uta.fi (position).
HR Specialist Minna Viinikainen, minna.viinikainen (at) uta.fi (recruitment process).