The HiLIFE – Institute of Biotechnology at the University of Helsinki, renowned for its international research excellence, is excited to announce an opening for a postdoctoral researcher to join the newly formed group of Dr. Alexander Mühleip.
Project Description
The research of the group is focused on understanding how protein complexes organise mitochondrial membranes in protozoan parasites and when disrupted by human mitochondrial disorders. The successful applicant will work on the structural and functional characterisation of protein complexes involved in mitochondrial energy conversion in malaria parasites using protein biochemistry, single-particle cryo-EM and in-situ cryo-electron tomography. Specifically, the project is aimed at visualisation of inner-membrane architecture and characterising parasite-specific modulation of membrane biogenesis. The project offers the unique opportunity to combine parasitology and mitochondrial biology with state-of-the-art structural biology techniques. The group benefits from in-house availability of a 200-kV Talos Artica microscope, complemented by access to 300-kV cryo-electron microscopes for data collection at international facilities.
About You
you are ambitious, goal-oriented, collegial and motivated to tackle challenging new projects
PhD degree (or be in the final stages of PhD submission) in cell/molecular biology, parasitology, protein biochemistry or a similar field
prior experience in cultivation of Plasmodium falciparum is essential
expertise in genetic engineering (e.g. CRISPR/Cas9) is strongly desired
high interest in learning structural biology methods (comprehensive cryo-EM training will be provided)
commitment to scientific excellence as demonstrated by a strong publication record
excellent command of English (working language at the institute)
strong communication, interpersonal, organizational and time management skills
What We Offer
a fixed-term 3-year position with possible extension
a collaborative, innovative and inclusive work environment
support and mentoring for postdoctoral fellowship applications (EMBO, Marie-Curie etc.)
a competitive salary depending on your qualifications and personal performance, 5-7 weeks of annual holiday leave, flexible working hours
financial support with Finnish visa and residency permits, if applicable
occupational health care and access to high-quality sports facilities
About The Institute Of Biotechnology, HiLIFE, University Of Helsinki
The Institute of Biotechnology is an independent research institute within the Helsinki Institute of Life Science (HiLIFE) , at the University of Helsinki, Finland, and at the global forefront of life science research with state-of-the-art research core facilities in genomics, biological imaging and structural biology. According to the 2024 Times Higher Education World University survey, the University of Helsinki is ranked among the top 80 universities world-wide in life science research. The University of Helsinki is committed to providing a welcoming environment for international researchers , offering comprehensive services and support for relocating to Finland—a country known for its high quality of life, excellent education system, and robust support for research and innovation.
How to apply?
Welcome with your application in English (click the ‘apply’ link), as soon as possible or no later than April 28th. Please note that applications will be continually reviewed. The position is available immediately or according to mutual agreement. Applications should include a cover letter, CV, and contact details of three references. For further information on the position, please contact Alexander Mühleip (alexander.muhleip@helsinki.fi).
Doctoral Researchers forDoctoral Education Pilot in Precision Cancer Medicine (ICANDOC)
The University of Helsinki is currently seeking to fill 236 three-year positions for doctoral researchers. These positions are part of a national initiative in doctoral education and are available within various doctoral education pilots. The appointments are set to commence on August 1, 2024, or on January 1, 2025.
As a doctoral researcher at the University of Helsinki, you will conduct your doctoral research as part of an international scientific community under the guidance of top researchers in your field.
122 of the positions are available in the iCANDOC precision cancer medicine pilot. In iCANDOC you will be part of a thriving research community based on the iCAN flagship aiming for discoveries and improved treatments in the area of digital precision cancer medicine. You will be able to leverage a globally unique ongoing pan-cancer study including thousands of patients and multitude of cutting-edge approaches and technologies in translational and clinical medicine as well as data sciences including AI/machine-learning approaches. The iCANDOC program aims to train professionals with various backgrounds to answer the increasing need of professionals in this area and including clinicians. In addition to outstanding supervisors including global leaders in this field, iCANDOC will benefit from an aligned postdoctoral program providing supervision support. With the help of iCANDOC partners including Helsinki University Hospital HUS as well as representatives of relevant private sector areas the program includes training and secondments enabling networking and linkages with potential future employees.
Candidates with a medical training may be considered for these positions with flexible working arrangement, in order to enable clinical work requiring employment at the hospital and beneficial for the thesis project. Further information on the pages of the national iCANDOC program and from icandoc-info@helsinki.fi .
Qualifications And Responsibilities
We are looking for motivated candidates who have demonstrated their capabilities in previous studies and are committed to completing their doctoral degree within the targeted three-year timeframe. In this position your responsibilities will include conducting research for your dissertation and completing the doctoral degree according to the curriculum of the doctoral program. Additionally, you may be involved in teaching and other duties, accounting for up to 5% of your annual working time at the University of Helsinki.
We Offer:
Opportunity to work in an international, multidisciplinary research community
High-quality research infrastructure and support services
Comprehensive support for initiating and advancing your research
Competitive salary (starting salary typically 2,400–2,800 €/month, depending on the appointees’ qualifications and experience), along with benefits such as healthcare and other employee benefits
Assistance with integration into Finland and the University of Helsinki community
Application Process and Selection Criteria
You may apply through two pathways:
Applicants applying through the first pathway are required to have:
A research plan drawn up in collaboration with the supervisor
Supervision plan drawn up in collaboration with the supervisor
A study right for a doctoral degree awarded no earlier than 1.11.2023 OR a stage of studies that allows the candidate to be awarded a right to study for a doctoral degree during the probationary period, i.e. within six months of the start of employment
Applicants applying through the second pathway are required to have:
An example of a research idea and a related concept paper. Candidates who progress to the next stage of the call will have the opportunity to apply for a supervisor and complete their application with an actual research and supervision plan at a later stage.
A stage of studies that allows the candidate to be awarded a right to study for a doctoral degree during the probationary period, i.e. within six months from the start of employment
The selection process will consider:
Suitability of the research plan to the chosen pilot project
Quality and feasibility of the research plan within the three-year timeframe
Planned connections to the professional world and the significance of the position for the applicant’s career after completing the doctoral degree
Feasibility of completing the dissertation within three years, as demonstrated in the supervision plan
Additionally, we expect from all applicants:
Commitment to three years of intensive and work
Strong motivation and previous evidence of the ability to achieve results and complete the project on schedule
Creativity along with the ability for analytical and conceptual thinking, a determined and independent work approach, collegiality, the ability to engage in constructive collaboration with others, and inspire others
Fluent oral proficiency in English and the ability to write scientific texts in English
The appointed doctoral researchers are expected to reside in Finland, though temporary research visits abroad are possible. If relocating, employment can only begin after arriving in Finland.
In addition, there may be consortium-specific requirements or specifications, which are listed in the application instructions online.
Application Instructions and Deadline
Please review the application instructions carefully and submit your application no later than April 22.
Please note that as part of the selection process, we utilize an online competency assessment for all eligible applicants. Please ensure that you allocate approximately one hour between April 27 and April 29 (EEST) to complete the test.
The University of Helsinki is committed to promoting equality, diversity, and inclusion in all aspects of our operations. We encourage applicants from diverse backgrounds, including different genders, linguistic and cultural backgrounds, and minority groups.
Doctoral Researchers for National Doctoral Education Pilot Based on Immune System (IMMUDOCS)
The University of Helsinki is currently seeking to fill 236 three-year positions for doctoral researchers. These positions are part of a national initiative in doctoral education and are available within various doctoral education pilots. The appointments are set to commence on August 1, 2024, or on January 1, 2025.
As a doctoral researcher at the University of Helsinki, you will conduct your doctoral research as part of an international scientific community under the guidance of top researchers in your field.
This research area focuses on immunology including all types of inflammatory diseases, which are future megatrend in healthcare. They all are driven by aberrant immune responses, and immunological interventions are at the heart of their prevention, diagnosis, and treatment. Healthcare urgently needs specialists who understand these immunological areas.
We are looking for 10 doctoral researchers for 3-year doctoral positions to work in the fields of immunology, immunology-based drug development and/or diagnostics. The research can be basic, translational and/or clinical.
Suitable candidates have a background in biomedicine, medicine, life sciences or other relevant discipline.
More information on this research area
Qualifications And Responsibilities
We are looking for motivated candidates who have demonstrated their capabilities in previous studies and are committed to completing their doctoral degree within the targeted three-year timeframe. Your responsibilities will include conducting research for your dissertation and completing the doctoral degree according to the curriculum of the doctoral program. Additionally, you may be involved in teaching and other duties, accounting for up to 5% of your annual working time.
We Offer:
Opportunity to work in an international, multidisciplinary research community
High-quality research infrastructure and support services
Comprehensive support for initiating and advancing your research
Competitive salary (starting salary typically 2,400–2,800 €/month, depending on the appointees’ qualifications and experience), along with benefits such as healthcare and other employee benefits
Assistance with integration into Finland and the University of Helsinki community
Application Process and Selection Criteria
You may apply through two pathways:
Applicants applying through the first pathway are required to have:
A research plan drawn up in collaboration with the supervisor
Supervision plan drawn up in collaboration with the supervisor
A study right for a doctoral degree awarded no earlier than 1.11.2023 OR a stage of studies that allows the candidate to be awarded a right to study for a doctoral degree during the probationary period, i.e. within six months of the start of employment
Applicants applying through the second pathway are required to have:
An example of a research idea and a related concept paper. Candidates who progress to the next stage of the call will have the opportunity to apply for a supervisor and complete their application with an actual research and supervision plan at a later stage.
A stage of studies that allows the candidate to be awarded a right to study for a doctoral degree during the probationary period, i.e. within six months from the start of employment
The selection process will consider:
Suitability of the research plan to the chosen pilot project
Quality and feasibility of the research plan within the three-year timeframe
Planned connections to the professional world and the significance of the position for the applicant’s career after completing the doctoral degree
Feasibility of completing the dissertation within three years, as demonstrated in the supervision plan
Additionally, we expect from all applicants:
Commitment to three years of intensive and full-time work
Strong motivation and previous evidence of the ability to achieve results and complete the project on schedule
Creativity along with the ability for analytical and conceptual thinking, a determined and independent work approach, collegiality, the ability to engage in constructive collaboration with others, and inspire others
Fluent oral proficiency in English and the ability to write scientific texts in English
The appointed doctoral researchers are expected to reside in Finland, though temporary research visits abroad are possible. If relocating, employment can only begin after arriving in Finland.
In addition, there may be consortium-specific requirements or specifications, which are listed in the application instructions online.
Application Instructions and Deadline
Please review the application instructions carefully and submit your application no later than April 22.
Please note that as part of the selection process, we utilize an online competency assessment for all eligible applicants. Please ensure that you allocate approximately one hour between April 27 and April 29 (EEST) to complete the test.
The University of Helsinki is committed to promoting equality, diversity, and inclusion in all aspects of our operations. We encourage applicants from diverse backgrounds, including different genders, linguistic and cultural backgrounds, and minority groups.
Kiinnostaako sinua ura vahvasti kasvavalla, kehittyvällä ja kansainvälisesti merkittävällä terveysteknologia-alalla? Haluatko olla mukana rakentamassa ratkaisuja ihmisten terveyden ja hyvinvoinnin edistämiseksi? Kasva kysytyksi terveysteknologiaosaajaksi ja löydä uusi työ!
Teknologia on lähempänä terveydenhuoltoa kuin koskaan ja ammattitaitoisista tulevaisuuden healthtech-osaajista on todellinen kysyntä. Vauhdikkaasti kasvavalla alalla uudet teknologiat vaikuttavat palveluihin ja tuotekehitykseen merkittävällä tavalla, mikä luo alalle paljon uusia työpaikkoja. Uudet työt tarvitsevat tekijänsä – oletko sinä etsimämme osaaja?
Kasva kysytyksi healthtech-alan osaajaksi ja löydä uusi työ
Useat Uudenmaan, Varsinais-Suomen sekä Pohjois-Savon alueen yritykset etsivät nyt toteutettavan HealthTech Academy -rekrytoivan koulutusohjelman kautta riveihinsä tulevaisuuden osaajia vauhdittamaan alan kasvutarinaa. Uusia osaajia etsivät mm. DelsiTech, LED Tailor ja Sharkmed.
Rooleja on useita ja haemme osaajia hyvin erilaisiin tehtäviin, kuten tuotekehitykseen (laite, kemia tai ohjelmisto), laadunhallintaan tai tekniskaupallisiin tehtäviin, kuten terveysteknologiatuotteiden myynti- ja markkinointitehtäviin, data-analytiikkarooleihin sekä projektienhallintaan.
Mahdollisuuksia on monia ja tehtäviä on tarjolla niin alalle uusina tuleville tekijöille, alanvaihtajille ja kokeneemmillekin asiantuntijoille, jotka haluavat syventää osaamistaan alan parissa. Rekrytoivat yritykset etsivät avoimiin tehtäviin ennen kaikkea motivoituneita ja oman ammattitaidon kehittämisestä innostuneita uusia osaajia. Sinun ei siis välttämättä tarvitse vielä hakuvaiheessa olla valmis asiantuntija – me autamme ohjelman aikana sinua kasvamaan uuteen tehtävääsi!
Voit olla etsimämme henkilö, mikäli sinulta löytyy taustaa tai kokemusta työn, opintojen tai harrastuneisuuden kautta esimerkiksi jostakin seuraavista osa-alueista:
luonnontieteistä tai bioinformatiikasta
laadunhallinnasta ja -varmistuksesta
laitehuollosta tai sähkö-, mekaniikka-, tai elektroniikkasuunnittelusta
tuotekehityksestä tai projektinvedosta
ohjelmistokehityksestä tai ICT-alasta
hoito-, tutkimus- tai laboratoriotyöstä
myynnistä, markkinoinnista tai tuotehallinnasta
terveysalasta
Uusien osaajien rekrytointi tapahtuu HealthTehch Academy F.E.C-koulutuksen kautta. Ohjelma sisältää laadukasta asiantuntijakoulutusta (noin 30 % ohjelmasta). Pääpaino ohjelman aikana osallistujalla on kasvaa uuteen rooliin yhteistyöyrityksessä työn kautta tapahtuvassa oppimisessa – käytännön työtehtävissä ja projekteissa.
Terveysteknologia-ala on tiukasti säädelty, ja regulaatioiden tunteminen on avainasemassa alan työntekijöillä, oli rooli sitten mikä tahansa. HealthTech Academy tarjoaa katsauksen terveysteknologian regulaatioihin ja auttaa sinua hankkimaan tarvittavat taidot ja tiedot alalla menestymiseen.
Voit hakea ohjelmaan, mikäli olet tällä hetkellä työttömänä työnhakijana, työttömyysuhan alaisena tai pian päättyvässä määräaikaisessa työsuhteessa oleva ja työnhakusi TE-palveluissa on voimassa.
Hae mukaan heti!
Hae mukaan mahdollisimman pian, viimeistään 15.4.2024! Jättämällä hakemuksesi mahdollisimman pian pystymme varmistamaan jouhevan hakuprosessin sekä tukemaan sinua haun aikana.
Etenet hakuprosessissa, kun olet täyttänyt omalta alueeltasi kaksi hakemusta:
Uusimaa:
Täytä TE-toimiston hakulomake.Löydät HealthTech Academy -rekrytoivan koulutusohjelman koulutusnumerolla 720179. Esivalinta koulutukseen tehdään tämän TE-toimiston hakemuksen tietojen perusteella, joten perustele hakemuksesi huolellisesti.
Täytä Sarasen osaamisprofiili. Sarasen osaamisprofiili toimii käyntikorttinasi kaikkiin ohjelman rekrytoiviin yhteistyöyrityksiin, jonka kautta pääset kertomaan taustastasi, osaamisestasi ja motivaatiostasi. Profiilin avulla vähennät työpaikkojen hakuammuntaa ja hakemuksien määrää!
Varsinais-Suomi:
Täytä TE-toimiston hakulomake.Löydät HealthTech Academy -rekrytoivan koulutusohjelman koulutusnumerolla 712223. Esivalinta koulutukseen tehdään tämän TE-toimiston hakemuksen tietojen perusteella, joten perustele hakemuksesi huolellisesti.
Täytä Sarasen osaamisprofiili.Sarasen osaamisprofiili toimii käyntikorttinasi kaikkiin ohjelman rekrytoiviin yhteistyöyrityksiin, jonka kautta pääset kertomaan taustastasi, osaamisestasi ja motivaatiostasi. Profiilin avulla vähennät työpaikkojen hakuammuntaa ja hakemuksien määrää!
Pohjois-Savo:
(Haku avautuu pian!)
Ohjelman toteuttavat tiiviissä yhteistyössä ELY-keskus, TE-palvelut, rekrytoivat yritykset, HealthTech Finland ry ja Saranen.
Pohjois-Savo: Laura Hovi, laura.hovi@saranen.fi tai soittoaikoina (maanantaisin klo 12.30–13.30 & keskiviikkoisin klo 9–10) numerosta 040 673 6381
Ohjelmasta järjestetään TE-live hakijainfotilaisuus maanantaina 8.4. klo 13.
Tervetuloa kuulemaan lisää ohjelmasta! Voit lähettää ennakkoon kysymyksesi TE-liven sivuilla sekä myös esittää kysymyksiäsi koko lähetyksen ajan anonyymisti chatin kautta.
HealthTech Academy -rekrytoivassa koulutusohjelmassa yhdistyvät käytännön työtehtävät sekä terveysteknologia-alan asiantuntijakoulutus ainutlaatuisella tavalla. Ohjelma tarjoaa sinulle aidon mahdollisuuden vaikuttaa uraasi syventämällä omaa ammattiosaamistasi sekä löytää tulevan työpaikkasi.
Koulutuksesta eväät työllistymiseen. Koulutusohjelman tärkeimpänä tavoitteena on työllistää sinut yhteistyöyritykseen 6 kk ohjelman päätteeksi. Tavoitteemme on löytää juuri sinun urakehitystäsi parhaiten tukeva rooli! Luelisää hakuprosessista, usein kysytyistä kysymyksistä ja aiempien osallistujien kokemuksista täältä.
Asiantuntijuus uudelle tasolle. Saat ohjelman aikana laadukasta koulutusta alan johtavilta tekijöiltä n. 25 koulutuspäivän myötä, sekä pääset hyödyntämään oppimaasi uudessa työroolissasi. Lopputuloksena kasvatat oman asiantuntijuutesi uudelle tasolle. Koulutus on osallistujille maksuton ja se toteutetaan toistaiseksi etätoteutuksena.
Ohjelma avaa useita erilaisia urapolkuja. Useat eturivin healthtech-yritykset etsivät riveihinsä uusia osaajia, sillä terveysteknologia-alan osaajista on suuri pula. Yritykset etsivät ohjelman kautta tekijöitä erilaisiin ja eritasoisiin kaupallisiin sekä teknisiin tehtäviin.
Koulutuksen tarkoituksena on työllistää sinut yhteistyöyritykseen ohjelman kautta. Tämä voi tapahtua ohjelman päätteeksi, tai jopa ohjelman aikana. Keskimäärin yli 80% osallistujista rekrytoituu uuteen rooliin koulutusohjelman päätteeksi. Ohjelman ajan olet yritykseen koulutussuhteessa ja yritys ei maksa sen ajalta palkkaa. Koulutuksen aikana saat samaa työttömyysetuutta, kuin työttömänä ollessasi. Saat myös kulukorvausta koulutuspäivien ajalta. Jos koulutukseen osallistumisesta on sovittu työllistymissuunnitelmassasi, voi työttömyyskassa tai Kela maksaa koulutuksen ajalta korotettua työttömyysetuutta. Korotettuun etuuteen liittyvistä tarkemmista edellytyksistä, enimmäisajasta ja muusta saat tietoa työttömyysetuutesi maksajalta. Työ- ja palkkasuhde yrityksen kanssa on tavoitteena ohjelman jälkeen ja palkasta sovitaan siinä kohtaa yrityksen kanssa.
The University of Eastern Finland is inviting applications for a Project Researcher position on the Institute of Biomedicine, Kuopio Campus. The position will be filled for a two-year term from 1 May 2024 (or starting date as agreed). Please find more information below and submit your application by 8 April 2024.
Role and salary
We are seeking a highly motivated and talented Bioinformatician or Computational Biologist (PhD or MSc) interested in a career path as a core facility expert to join the UEF Bioinformatics Center. The goal of the bioinformatics core facility is to contribute to research excellence through standard and customized omics data analysis, as well as to implement innovative machine learning, data integrative and multimodal solutions. The hosting core facility is located in the School of Medicine, Faculty of Health Sciences, on the UEF Kuopio campus. The infrastructure is also part of the Biocenter Finland Bioinformatics Platform.
The Project Researcher will participate in research projects and develop biomedical and multimodal data analysis solutions for UEF Research Communities in cancer, metabolic, cardiovascular, and neurodegenerative diseases. You will join the growing local network of bioinformaticians. Depending on your profile and experience, you will have the opportunity to develop your expertise in multiomics analyses, combining omics and imaging data with clinical data from local cohorts and other resources such as FinnGen. UEF core facilities in single-cell genomics, metabolomics and biomedical imaging will offer opportunities to network with domain experts. You will have access to the local high throughput computational infrastructure of the Bioinformatics Center and the Finnish national computational infrastructure of CSC. The position also offers an opportunity to participate in teaching.
The main responsibilities of the Project Researcher include:
collaborating with biomedical and data analysis experts in research projects,
pre-processing and analysing different types of omics, multiomics or multimodal data, and
developing state-of-the-art workflows.
The position will be filled for a two-year term from 1 May 2024 (or starting date as agreed). The position will be filled for a fixed term due to it pertaining to a specific project tasks. A probationary period is applied to all new members of the staff.
The salary of the position is determined in accordance with the salary system of the Finnish universities. The salary comprises two elements: a job requirement element and a personal performance element. In these positions, the job-related salary element is based on level 5–6 (PhD) and level 3–4 (MSc) of the job requirement level chart, and the personal salary element is 6–50% of the job-related salary element. The estimated monthly salary at the beginning of the employment will be EUR 3.534 – 4.497/month for a PhD and EUR 2.689– 3.330 /month for a MSc.
Our requirements and expectations
We welcome highly motivated applicants with a bioinformatics or data science background and a high interest in biomedical data analysis.
Requirements
The person to be appointed as a Project Researcher must hold a PhD or MSc in bioinformatics, computational biology, data science or a related field. Applicants with a PhD or MSc degree from other fields must demonstrate to have substantial experience in bioinformatics data analysis.
Good understanding of machine learning methods.
Experience in the analysis of at least one of the following data types:
Genome or phenome-wide association
Bulk or single-cell transcriptomics
Bulk or single-cell epigenomics
Proteomics or metabolomics
Strong skills in R programming, Linux shell scripting and Python or other relevant scripting language.
Excellent written and spoken English skills.
Good communication skills as well as a high degree of independence and initiative.
The following will be considered an advantage:
Experience in GWAS, metabolomics, knowledge graphs or other multimodal data analysis.
Experience in the use of containers and version control.
Your benefits
You will have access to the university’s staff benefits, including
opportunity for flexible multi-location work
extensive occupational health care
broad selection of staff training
staff discount on lunch in our campus restaurants, as well as on a range of other services
affordable sports services and tax-free bike benefit
You will have an opportunity to work in an interesting/meaningful/diverse role as part of our international, creative, participatory and inclusive academic community.
Enjoy your life in Finland! Known for its cleanliness, welfare know-how, modern technology and superb education system, Finland is an exotic and safe country to work in. Please visit the Life in Finland section on our website to learn more.
How to apply?
Submit your application by using our electronic application form no later than 8 April 2024 by 24:00 (midnight) Finnish time (UTC+3)
Please note that you must include the following appendices in your application
For further information on the position, please contact Research Manager Virpi Ahola, virpi.ahola@uef.fi, +358-50-5687597 or visit https://bioinformatics.uef.fi
For further information on the application procedure, please contact: Human Resources hrbiomed@uef.fi
The Faculty of Health Sciences operates at the Kuopio Campus of the University of Eastern Finland. The Faculty offers education in medicine, dentistry, nutrition and pharmacy, as well as in some other central fields of the health care sector. The Faculty is research-intensive, and its internationally recognised research activities are closely linked to the strategic research areas of the University. There are approximately 3 090 degree students and about 580 PhD students in the Faculty. The faculty has 800 staff members.
The University of Eastern Finland (UEF) is the most multidisciplinary university in Finland. Our university employs approximately 3,200 employees, and our community includes approximately 16,000 degree students and 16,000 adult education students. Our campuses are located in Joensuu and Kuopio. We represent the world’s cutting edge of research in many fields and produce research-based knowledge, which is made openly available to benefit everyone. Learn more about our university at www.uef.fi/en. Read also about UEF as a working community and employer and the career stories of our employees.
We are looking for a highly motivated doctoral researcher to join the 3-year period ImmuDocs Doctoral Education Pilot project “Macrophages and neutrophils in cancer progression”, led by Professor Jyrki Heino, University of Turku.
Project description:
Malignant tumours consist of transformed cancer cells and of numerous other cell types including cancer associated fibroblasts (CAFs), tumour associated macrophages (TAMs), neutrophils, lymphocytes and endothelial cells. All cell types regulate each others’ phenotype and behaviour and cancer progression. Extracellular matrix (ECM) – mainly produced by CAFs – is an important component of the tumour microenvironment. ECM has a major impact on cancer cells, on the efficacy of immunotherapies and finally on the disease outcome.
We have developed new 3D spheroid-based methods to study the interactions of different cell types: human cutaneous squamous cellular carcinoma (cSCC) cells, CAFs and TAMs/neutrophils. Using e.g. mass spectrometry, RNA-sequencing, microscopy and cellular assays for proliferation, phenotype/plasticity and invasion the project aims to unveil the TAM and neutrophil based regulatory mechanisms of invasion and ECM remodelling. Furthermore, our preliminary results have revealed the remarkable plasticity of TAMs. The project aims to find molecular mechanisms used by CAFs and cSCC cells to regulate TAM phenotype.
In our recent paper we showed that the spheroid model can be used to successfully screen potential drug molecules (Siljamäki et al., Oncogene, 2023. PMID: 37864034). In this doctoral project the spheroids containing three different cell types will be used to test the effects of the inhibitors of critical signalling pathways. The model also allows testing of putative drug molecules targeted to macrophages and neutrophils.
Finally, we have recently established a method to combine laser capture microscopy to mass spectrometry and shown that it is possible to get detailed information about e.g. ECM composition in different tumour areas of paraffin embedded SCC tumours and their metastases. This in vivo information is critical for interpretation of the results from in vitro experiments focused on the effects of macrophages and neutrophils on the composition and organization of the ECM.
Orion’s Immuno-Oncology (IO) research team is looking to recruit an enthusiastic and motivated Immunology and flow-cytometry scientist to join the IO team. In this role you will contribute to IO target identification and validation, coupled with being responsible for supporting multi colour flow cytometry needs. In this role you have a unique opportunity to contribute in a range of treatment modalities ranging from small molecules, large molecules (bispecific & monospecific antibodies) and CAR T cells.
The responsibilities of this role include the following (including, but not limited to);
Design and perform in vitro immune assays and treatment with oncology drugs in conjunction with internal project teams.
Desing multi-colour flow cytometry antibody panels to detection and FACS sorting of a range of Immune cells.
Establish and validate human and mouse in vitro primary immune cells assays to define the mechanism of action of IO drugs.
Co-ordinate with the line-manager to ensure timely delivery of data and report if any issues encountered or foreseen.
Be responsible person for flow cytometry training for internal staff and regular maintenance of flow cytometry and cell sorter instruments.
Provide clear reports and presentations as required and participate in project team meetings and organisation meetings.
Working in close collaboration with other scientists and technicians.
This is a fixed-term contract of employment (parental leave) and location is Turku, Finland.
Description Of Unit
Immuno-Oncology (IO) is one of the three Research teams in Orion’s Oncology R&D. IO team is accountable for novel drug discovery projects, identification of unmet need, identification & experimental validation of potential IO drug targets within state-of-the-art laboratories and technologies.
We Offer
We offer you the opportunity to show your talent in one of the most innovative* companies in Finland. You get a chance to work in a challenging field of work with excellent colleagues. You will also have the chance to do meaningful work and build the future of Orion. We are striving for excellence in everything we do. We succeed, learn together and appreciate each other. You’ll be empowered to deliver value. Please visit our website to find further information about Orion as an employer.
Requirements
To be a successful ideally you should have the following educational and professional work experiences:
PhD degree in Immunology or related field with 2+ years of relevant experience.
Strong and deep knowledge building multi colour panels, flow cytometry and cell sorter instruments
Strong in vitro research experience using primary immune cells assays is a must
Demonstrate ability to independently design, conduct and interpret the data from complex in vitro immune cell assays and flow cytometry is a must.
Demonstrate proficiency in isolation of immune cells and processing samples for multi-colour flow cytometry, multiplex ELISA, IHC, single cell RNA sequencing and gene expression analysis.
Competency in using graph pad prism, flowjo, nSolver software and other standard office software.
Excellent attention to details with strong communication skills.
Flexibility and willingness to learn new techniques and take additional responsibilities as a member of the research team.
Additional Information
We look forward to hearing from you as soon as possible, so please send your application in English by 10th March at the latest.
For further information, please contact Dr Anil Thotakura, Head of Immuno-oncology, +358 50 966 7229 on 28th Feb 4:00 to 5:00pm or 4th March 4:30 to 5:30pm or 7th March 4:00 to 5:00pm
Approved medical examination which also includes drug testing is required prior to the employment. We will also carry out a security clearance prior to the employment for the selected person. Orion Corporation operates in more than 30 countries, where we Orionees, 3600 in total, work in all kinds of positions. Among us there are Research Scientists, Laboratory Technicians, Engineers and IT Specialists as well as people working in Production, just to mention some examples. We offer diverse and responsible jobs to our personnel in a truly multi-disciplinary work environment. We encourage people to develop their competences and offer opportunities to affect the job description and creating their own career path at Orion. We are searching for top talents who are ready to share our passion for the work that we do.
Suomen Solubiologit ry järjestää kesätyönhakuwebinaarin! Webinaarin aikana kuulemme Eurofins Environment Testing Finlandin yritysesittelyn sekä kesälle 2024 tarjolla olevien työpaikkojen esittelyn. Tilaisuuden osallistujilla on myös mahdollisuus esittää kysymyksiä Eurofinsin edustajille.
Webinaarin tiedot:
Päivänmäärä: Maanantai 11.3.2024
Aika: Klo 15-16
Paikka: Zoom
Kieli: Suomi (Eurofinsin työkieli on suomi)
Miksi osallistua?
Kuulet lisää Eurofinsin tarjolla olevista kesätyöpaikoista
Pääset tutustumaan Eurofins-yritykseen laajemmin – entä mitä työllistymismahdollisuuksia on Suomen ulkopuolella?
Pääset esittämään kysymyksiä henkilökohtaisesti Eurofinsin edustajille
Saat vinkkejä ja ohjeita onnistuneeseen työnhakuprosessiin
Varmista siis paikkasi tässä webinaarissa ja tule kuuntelemaan minkälaisia teollisuus- ja ympäristölaboratorioalan kesätöitä Eurofins Environment Testing Finlandilla on tarjota!
We are delighted to invite you to the celebration of our society’s 50th anniversary on 15th of March 2024 in Jyväskylä, Ambiotica, Survontie 9c! This special day will be filled with exploring cutting-edge science and timely topics with your colleagues from across Finland, and a delightful anniversary dinner with live music.
Date: Friday 15th of March Time: Society annual meeting 12:00pm Anniversary seminar: 2:00pm – 6:00pm Anniversary dinner: 6:00pm
Venue: Ambiotica Lecture Hall YAA303, Ylistönrinne Survontie 9c, 40500 Jyväskylä
Anniversary seminar theme: Towards smarter care and health innovations using cell biology
Seminar sessions: 1. Challenges of health communication Speakers: Tuomas Aivelo (University of Helsinki), Pauli Ohukainen (Tervettä Skeptisyyttä Oy, Oura Health) 2. Artificial intelligence in cell biology research and healthcare Speakers: Leena Latonen (University of Eastern Finland), Lassi Paavolainen (Institute for Molecular Medicine Finland), Juha Väyrynen (University of Oulu) 3. Young scientists as future pioneers in cell biology Speakers: Sonja Koivukoski (University of Eastern Finland), Veera Luukkonen (Åbo Akademi)
Anniversary dinner: Start time: 6:00pm Venue: Ravintola Ylistö, YFL-building, Survontie 9c, 40500 Jyväskylä Dress code: Smart casual Dinner price: 25€, 15€ for students and society members
Dinner menu: Starter: Mixed green salad with pomegranate and lemon vinaigrette Seasonal kale with herbs and pine nuts Ricotta ravioli with cherry tomatoes and spinach Spelt and beetroot salad Smoked vendace and potato salad
Main course: Slow-cooked beef cheek with blackcurrant-infused red wine sauce Roasted garlic-rosemary tomatoes and vegetables
Dessert: Raspberry-white chocolate cake
Please specify any allergies or food restrictions when registering!
Osallistu Suomen Solubiologit ry:n haalarimerkkikilpailuun!
Suomen Solubiologit ry juhlii tänä vuonna 50-vuotista taivaltaan, ja haluamme juhlistaa merkittävää vuosipäivää uuden, upean haalarimerkin avulla! Vanhat haalarimerkkimme ovat loppuneet, joten etsimme nyt luovia jäseniämme ja seuraajiamme suunnittelemaan seuraavaa merkkiä yhdistyksellemme.
Kilpailuohjeet:
Suunnittele haalarimerkki, joka kuvastaa Suomen Solubiologit ry:tä, ja mahdollisesti sen 50-vuotista taivalta.
Lähetä suunnittelemasi haalarimerkkikuva sähköpostitse osoitteeseen suomensolubiologit@gmail.com viimeistään 29.2.2024 mennessä.
Palkinnot:
Voittaja saa vuoden ilmaisen jäsenyyden ja oman suunnittelemansa haalarimerkin.
Vaihtoehtoisesti voittaja voi valita ilmaisen illallisen yhdistyksemme 50-vuotisjuhlatapahtumassa Jyväskylässä 15.3.2024.
Osallistu nyt ja ota osaa juhlavuoteemme!
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Join The Finnish Society for Cell Biology Patch Design contest!
The Finnish Society for Cell Biology celebrates its 50th anniversary this year, and we want to commemorate this milestone with a brand new patch! Our old patches are out of stock, so we’re calling our creative members and followers to design a new patch for our society.
Contest guidelines:
Design a patch that represents The Finnish Society for Cell Biology, and perhaps its 50 years of history.
